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Aliases for LEPROTL1 Gene

Aliases for LEPROTL1 Gene

  • Leptin Receptor Overlapping Transcript-Like 1 2 3
  • Endospanin-2 3 4
  • HSPC112 3
  • VPS55 3
  • My047 3

External Ids for LEPROTL1 Gene

Summaries for LEPROTL1 Gene

GeneCards Summary for LEPROTL1 Gene

LEPROTL1 (Leptin Receptor Overlapping Transcript-Like 1) is a Protein Coding gene. An important paralog of this gene is LEPROT.

UniProtKB/Swiss-Prot for LEPROTL1 Gene

  • Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEPROTL1 Gene

Genomics for LEPROTL1 Gene

Genomic Location for LEPROTL1 Gene

30,095,398 bp from pter
30,177,208 bp from pter
81,811 bases
Plus strand

Genomic View for LEPROTL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LEPROTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEPROTL1 Gene

Regulatory Elements for LEPROTL1 Gene

Proteins for LEPROTL1 Gene

  • Protein details for LEPROTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leptin receptor overlapping transcript-like 1
    Protein Accession:
    Secondary Accessions:
    • E9PHP8
    • Q9BW48

    Protein attributes for LEPROTL1 Gene

    131 amino acids
    Molecular mass:
    14428 Da
    Quaternary structure:
    • Interacts with RAB13.

    Alternative splice isoforms for LEPROTL1 Gene


neXtProt entry for LEPROTL1 Gene

Proteomics data for LEPROTL1 Gene at MOPED

Post-translational modifications for LEPROTL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LEPROTL1 Gene

Domains for LEPROTL1 Gene

Protein Domains for LEPROTL1 Gene



  • Belongs to the OB-RGRP/VPS55 family.:
    • O95214
genes like me logo Genes that share domains with LEPROTL1: view

No data available for Gene Families for LEPROTL1 Gene

Function for LEPROTL1 Gene

Molecular function for LEPROTL1 Gene

UniProtKB/Swiss-Prot Function: Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

Gene Ontology (GO) - Molecular Function for LEPROTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LEPROTL1: view

Phenotypes for LEPROTL1 Gene

genes like me logo Genes that share phenotypes with LEPROTL1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LEPROTL1 Gene

Localization for LEPROTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEPROTL1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LEPROTL1 Gene COMPARTMENTS Subcellular localization image for LEPROTL1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LEPROTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LEPROTL1: view

Pathways for LEPROTL1 Gene

SuperPathways for LEPROTL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LEPROTL1 Gene


No data available for Pathways by source for LEPROTL1 Gene

Transcripts for LEPROTL1 Gene

Unigene Clusters for LEPROTL1 Gene

Leptin receptor overlapping transcript-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LEPROTL1 Gene

No ASD Table

Relevant External Links for LEPROTL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LEPROTL1 Gene

mRNA expression in normal human tissues for LEPROTL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LEPROTL1 Gene

SOURCE GeneReport for Unigene cluster for LEPROTL1 Gene Hs.146585

mRNA Expression by UniProt/SwissProt for LEPROTL1 Gene

Tissue specificity: Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle
genes like me logo Genes that share expressions with LEPROTL1: view

Orthologs for LEPROTL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LEPROTL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LEPROTL1 36
  • 99.75 (n)
  • 100 (a)
  • 99 (a)
(Bos Taurus)
Mammalia LEPROTL1 36
  • 91.6 (n)
  • 98.47 (a)
  • 76 (a)
(Canis familiaris)
Mammalia LEPROTL1 36
  • 95.93 (n)
  • 99.24 (a)
  • 74 (a)
(Mus musculus)
Mammalia Leprotl1 36
  • 89.06 (n)
  • 98.47 (a)
Leprotl1 16
Leprotl1 37
  • 76 (a)
(Monodelphis domestica)
Mammalia LEPROTL1 37
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia LEPROTL1 37
  • 52 (a)
(Rattus norvegicus)
Mammalia Leprotl1 36
  • 87.53 (n)
  • 97.71 (a)
(Gallus gallus)
Aves LEPROTL1 36
  • 84.73 (n)
  • 94.66 (a)
  • 73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28972 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486533 36
  • 79.39 (n)
  • 90.08 (a)
(Danio rerio)
Actinopterygii LEPROTL1 37
  • 62 (a)
wufb95c07 36
zgc:92045 36
  • 71.25 (n)
  • 86.26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008693 36
  • 53.17 (n)
  • 49.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30423 37
  • 36 (a)
(Caenorhabditis elegans)
Secernentea C30B5.2 36
  • 54.33 (n)
  • 51.97 (a)
C30B5.2 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS55 37
  • 25 (a)
VPS55 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
Species with no ortholog for LEPROTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LEPROTL1 Gene

Gene Tree for LEPROTL1 (if available)
Gene Tree for LEPROTL1 (if available)

Paralogs for LEPROTL1 Gene

Paralogs for LEPROTL1 Gene

genes like me logo Genes that share paralogs with LEPROTL1: view

Variants for LEPROTL1 Gene

Sequence variations from dbSNP and Humsavar for LEPROTL1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2656 -- 30,108,003(-) GTAAT(A/G)TTGTA intron-variant
rs2657 -- 30,107,887(-) ATGCA(A/G)TTAGT intron-variant
rs13693 -- 30,106,007(-) GTATG(C/T)TTACA intron-variant, utr-variant-3-prime
rs1062821 -- 30,107,186(+) TTGTC(C/T)GAGTT intron-variant, utr-variant-3-prime
rs1355412 -- 30,128,167(+) GCTCC(A/G)ACTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LEPROTL1 Gene

Variant ID Type Subtype PubMed ID
nsv831277 CNV Gain 17160897
nsv6138 CNV Insertion 18451855

Relevant External Links for LEPROTL1 Gene

HapMap Linkage Disequilibrium report

Disorders for LEPROTL1 Gene

Relevant External Links for LEPROTL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LEPROTL1: view

No data available for UniProtKB/Swiss-Prot for LEPROTL1 Gene

Publications for LEPROTL1 Gene

  1. Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1). (PMID: 11342119) Huang Y. … Mao Y.M. (Biochim. Biophys. Acta 2001) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. (PMID: 19876004) Corpeleijn E. … Blaak E.E. (Obesity (Silver Spring) 2010) 3 49
  5. LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. (PMID: 19907080) Touvier T. … Bailleul B. (J. Clin. Invest. 2009) 3 4

Products for LEPROTL1 Gene

Sources for LEPROTL1 Gene

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