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Aliases for LEPROTL1 Gene

Aliases for LEPROTL1 Gene

  • Leptin Receptor Overlapping Transcript-Like 1 2 3
  • Endospanin-2 3 4
  • HSPC112 3
  • VPS55 3
  • My047 3

External Ids for LEPROTL1 Gene

Previous GeneCards Identifiers for LEPROTL1 Gene

  • GC08P029868
  • GC08P030404
  • GC08P030010
  • GC08P030072
  • GC08P028497

Summaries for LEPROTL1 Gene

GeneCards Summary for LEPROTL1 Gene

LEPROTL1 (Leptin Receptor Overlapping Transcript-Like 1) is a Protein Coding gene. An important paralog of this gene is LEPROT.

UniProtKB/Swiss-Prot for LEPROTL1 Gene

  • Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEPROTL1 Gene

Genomics for LEPROTL1 Gene

Regulatory Elements for LEPROTL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LEPROTL1 Gene

Chromosome:
8
Start:
30,095,398 bp from pter
End:
30,177,208 bp from pter
Size:
81,811 bases
Orientation:
Plus strand

Genomic View for LEPROTL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LEPROTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEPROTL1 Gene

Proteins for LEPROTL1 Gene

  • Protein details for LEPROTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95214-LERL1_HUMAN
    Recommended name:
    Leptin receptor overlapping transcript-like 1
    Protein Accession:
    O95214
    Secondary Accessions:
    • E9PHP8
    • Q9BW48

    Protein attributes for LEPROTL1 Gene

    Size:
    131 amino acids
    Molecular mass:
    14428 Da
    Quaternary structure:
    • Interacts with RAB13.

    Alternative splice isoforms for LEPROTL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LEPROTL1 Gene

Proteomics data for LEPROTL1 Gene at MOPED

Post-translational modifications for LEPROTL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LEPROTL1 Gene

Domains & Families for LEPROTL1 Gene

Protein Domains for LEPROTL1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95214

UniProtKB/Swiss-Prot:

LERL1_HUMAN :
  • Belongs to the OB-RGRP/VPS55 family.
Family:
  • Belongs to the OB-RGRP/VPS55 family.
genes like me logo Genes that share domains with LEPROTL1: view

No data available for Gene Families for LEPROTL1 Gene

Function for LEPROTL1 Gene

Molecular function for LEPROTL1 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

Phenotypes for LEPROTL1 Gene

genes like me logo Genes that share phenotypes with LEPROTL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LEPROTL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for LEPROTL1 Gene

Localization for LEPROTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEPROTL1 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for LEPROTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LEPROTL1: view

No data available for Subcellular locations from COMPARTMENTS for LEPROTL1 Gene

Pathways & Interactions for LEPROTL1 Gene

SuperPathways for LEPROTL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LEPROTL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LEPROTL1 Gene

Drugs & Compounds for LEPROTL1 Gene

No Compound Related Data Available

Transcripts for LEPROTL1 Gene

Unigene Clusters for LEPROTL1 Gene

Leptin receptor overlapping transcript-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LEPROTL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LEPROTL1 Gene

No ASD Table

Relevant External Links for LEPROTL1 Gene

GeneLoc Exon Structure for
LEPROTL1
ECgene alternative splicing isoforms for
LEPROTL1

Expression for LEPROTL1 Gene

mRNA expression in normal human tissues for LEPROTL1 Gene

Protein differential expression in normal tissues from HIPED for LEPROTL1 Gene

This gene is overexpressed in Plasma (41.4), Retina (7.0), and Spinal cord (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LEPROTL1 Gene



SOURCE GeneReport for Unigene cluster for LEPROTL1 Gene Hs.146585

mRNA Expression by UniProt/SwissProt for LEPROTL1 Gene

O95214-LERL1_HUMAN
Tissue specificity: Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle
genes like me logo Genes that share expression patterns with LEPROTL1: view

Protein tissue co-expression partners for LEPROTL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LEPROTL1 Gene

Orthologs for LEPROTL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LEPROTL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LEPROTL1 35
  • 91.6 (n)
  • 98.47 (a)
LEPROTL1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LEPROTL1 35
  • 95.93 (n)
  • 99.24 (a)
LEPROTL1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Leprotl1 35
  • 89.06 (n)
  • 98.47 (a)
Leprotl1 16
Leprotl1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LEPROTL1 35
  • 99.75 (n)
  • 100 (a)
LEPROTL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Leprotl1 35
  • 87.53 (n)
  • 97.71 (a)
oppossum
(Monodelphis domestica)
Mammalia LEPROTL1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LEPROTL1 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves LEPROTL1 35
  • 84.73 (n)
  • 94.66 (a)
LEPROTL1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486533 35
  • 79.39 (n)
  • 90.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28972 35
zebrafish
(Danio rerio)
Actinopterygii wufb95c07 35
zgc:92045 35
  • 71.25 (n)
  • 86.26 (a)
LEPROTL1 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008693 35
  • 53.17 (n)
  • 49.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30423 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30B5.2 35
  • 54.33 (n)
  • 51.97 (a)
C30B5.2 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS55 36
  • 25 (a)
OneToMany
VPS55 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for LEPROTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LEPROTL1 Gene

ENSEMBL:
Gene Tree for LEPROTL1 (if available)
TreeFam:
Gene Tree for LEPROTL1 (if available)

Paralogs for LEPROTL1 Gene

Paralogs for LEPROTL1 Gene

genes like me logo Genes that share paralogs with LEPROTL1: view

Variants for LEPROTL1 Gene

Sequence variations from dbSNP and Humsavar for LEPROTL1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs28507902 -- 30,115,473(+) GCTTA(A/G)GTGAT intron-variant
rs28588350 -- 30,100,880(+) GTGCG(C/T)GCGTA intron-variant
rs28779184 -- 30,130,776(+) TCAAA(A/T)AAAAA intron-variant
rs33917700 -- 30,120,484(+) ATATA(-/T)TTTTT intron-variant
rs33971942 -- 30,099,817(+) AAGTG(-/TG)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LEPROTL1 Gene

Variant ID Type Subtype PubMed ID
nsv831277 CNV Gain 17160897
nsv6138 CNV Insertion 18451855

Variation tolerance for LEPROTL1 Gene

Residual Variation Intolerance Score: 41.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LEPROTL1 Gene

HapMap Linkage Disequilibrium report
LEPROTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEPROTL1 Gene

Disorders for LEPROTL1 Gene

Relevant External Links for LEPROTL1

Genetic Association Database (GAD)
LEPROTL1
Human Genome Epidemiology (HuGE) Navigator
LEPROTL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEPROTL1
genes like me logo Genes that share disorders with LEPROTL1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEPROTL1 Gene

Publications for LEPROTL1 Gene

  1. Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1). (PMID: 11342119) Huang Y. … Mao Y.M. (Biochim. Biophys. Acta 2001) 2 23 67
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 67
  5. Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. (PMID: 19876004) Corpeleijn E. … Blaak E.E. (Obesity (Silver Spring) 2010) 67

Products for LEPROTL1 Gene

Sources for LEPROTL1 Gene

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