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Aliases for LEPROTL1 Gene

Aliases for LEPROTL1 Gene

  • Leptin Receptor Overlapping Transcript-Like 1 2 3 5
  • Endospanin-2 3 4
  • HSPC112 3
  • VPS55 3
  • My047 3

External Ids for LEPROTL1 Gene

Previous GeneCards Identifiers for LEPROTL1 Gene

  • GC08P029868
  • GC08P030404
  • GC08P030010
  • GC08P030072
  • GC08P028497

Summaries for LEPROTL1 Gene

GeneCards Summary for LEPROTL1 Gene

LEPROTL1 (Leptin Receptor Overlapping Transcript-Like 1) is a Protein Coding gene. An important paralog of this gene is LEPROT.

UniProtKB/Swiss-Prot for LEPROTL1 Gene

  • Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEPROTL1 Gene

Genomics for LEPROTL1 Gene

Regulatory Elements for LEPROTL1 Gene

Enhancers for LEPROTL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LEPROTL1 on UCSC Golden Path with GeneCards custom track

Promoters for LEPROTL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LEPROTL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LEPROTL1 Gene

30,095,398 bp from pter
30,177,208 bp from pter
81,811 bases
Plus strand

Genomic View for LEPROTL1 Gene

Genes around LEPROTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEPROTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEPROTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEPROTL1 Gene

Proteins for LEPROTL1 Gene

  • Protein details for LEPROTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leptin receptor overlapping transcript-like 1
    Protein Accession:
    Secondary Accessions:
    • E9PHP8
    • Q9BW48

    Protein attributes for LEPROTL1 Gene

    131 amino acids
    Molecular mass:
    14428 Da
    Quaternary structure:
    • Interacts with RAB13.

    Alternative splice isoforms for LEPROTL1 Gene


neXtProt entry for LEPROTL1 Gene

Proteomics data for LEPROTL1 Gene at MOPED

Post-translational modifications for LEPROTL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LEPROTL1 Gene

Domains & Families for LEPROTL1 Gene

Protein Domains for LEPROTL1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OB-RGRP/VPS55 family.
  • Belongs to the OB-RGRP/VPS55 family.
genes like me logo Genes that share domains with LEPROTL1: view

No data available for Gene Families for LEPROTL1 Gene

Function for LEPROTL1 Gene

Molecular function for LEPROTL1 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
genes like me logo Genes that share phenotypes with LEPROTL1: view

Animal Models for LEPROTL1 Gene

MGI Knock Outs for LEPROTL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for LEPROTL1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LEPROTL1 Gene

Localization for LEPROTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEPROTL1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LEPROTL1 Gene COMPARTMENTS Subcellular localization image for LEPROTL1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for LEPROTL1 Gene

Pathways & Interactions for LEPROTL1 Gene

SuperPathways for LEPROTL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LEPROTL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for LEPROTL1 Gene

Drugs & Compounds for LEPROTL1 Gene

No Compound Related Data Available

Transcripts for LEPROTL1 Gene

Unigene Clusters for LEPROTL1 Gene

Leptin receptor overlapping transcript-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LEPROTL1 Gene

No ASD Table

Relevant External Links for LEPROTL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LEPROTL1 Gene

mRNA expression in normal human tissues for LEPROTL1 Gene

Protein differential expression in normal tissues from HIPED for LEPROTL1 Gene

This gene is overexpressed in Plasma (41.4), Retina (7.0), and Spinal cord (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LEPROTL1 Gene

SOURCE GeneReport for Unigene cluster for LEPROTL1 Gene Hs.146585

mRNA Expression by UniProt/SwissProt for LEPROTL1 Gene

Tissue specificity: Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.
genes like me logo Genes that share expression patterns with LEPROTL1: view

Protein tissue co-expression partners for LEPROTL1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LEPROTL1 Gene

Orthologs for LEPROTL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LEPROTL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LEPROTL1 35
  • 91.6 (n)
  • 98.47 (a)
  • 76 (a)
(Canis familiaris)
Mammalia LEPROTL1 35
  • 95.93 (n)
  • 99.24 (a)
  • 74 (a)
(Mus musculus)
Mammalia Leprotl1 35
  • 89.06 (n)
  • 98.47 (a)
Leprotl1 16
Leprotl1 36
  • 76 (a)
(Pan troglodytes)
Mammalia LEPROTL1 35
  • 99.75 (n)
  • 100 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Leprotl1 35
  • 87.53 (n)
  • 97.71 (a)
(Monodelphis domestica)
Mammalia LEPROTL1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia LEPROTL1 36
  • 52 (a)
(Gallus gallus)
Aves LEPROTL1 35
  • 84.73 (n)
  • 94.66 (a)
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486533 35
  • 79.39 (n)
  • 90.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28972 35
(Danio rerio)
Actinopterygii wufb95c07 35
zgc:92045 35
  • 71.25 (n)
  • 86.26 (a)
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008693 35
  • 53.17 (n)
  • 49.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30423 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea C30B5.2 35
  • 54.33 (n)
  • 51.97 (a)
C30B5.2 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS55 36
  • 25 (a)
VPS55 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for LEPROTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LEPROTL1 Gene

Gene Tree for LEPROTL1 (if available)
Gene Tree for LEPROTL1 (if available)

Paralogs for LEPROTL1 Gene

Paralogs for LEPROTL1 Gene

genes like me logo Genes that share paralogs with LEPROTL1: view

Variants for LEPROTL1 Gene

Sequence variations from dbSNP and Humsavar for LEPROTL1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2062787 -- 30,114,307(-) tctca(A/G)aaaaa intron-variant
rs2341176 -- 30,120,089(+) AATAA(A/T)TAAAT intron-variant
rs7830249 -- 30,097,700(+) atata(C/T)acaca intron-variant
rs7835466 -- 30,102,521(+) GTGAC(A/G)CATGC intron-variant
rs7836593 -- 30,116,556(+) ATGCT(C/T)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LEPROTL1 Gene

Variant ID Type Subtype PubMed ID
nsv831277 CNV Gain 17160897
nsv6138 CNV Insertion 18451855

Variation tolerance for LEPROTL1 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LEPROTL1 Gene

Disorders for LEPROTL1 Gene

Relevant External Links for LEPROTL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LEPROTL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEPROTL1 Gene

Publications for LEPROTL1 Gene

  1. Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1). (PMID: 11342119) Huang Y. … Mao Y.M. (Biochim. Biophys. Acta 2001) 2 3 4 23 67
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 3
  5. Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. (PMID: 19876004) Corpeleijn E. … Blaak E.E. (Obesity (Silver Spring) 2010) 3

Products for LEPROTL1 Gene

Sources for LEPROTL1 Gene