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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LEPROTL1 Gene

protein-coding   GIFtS: 49
GCID: GC08P030010

leptin receptor overlapping transcript-like 1

 Explore 2 diseases affiliated with
LEPROTL1 via our new
 Human Malady Compendium 
Biological research products
for LEPROTL1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Leptin Receptor Overlapping Transcript-Like 11 2
Vps551 2
My0471
HSPC1122

External Ids:    HGNC: 65551   Entrez Gene: 234842   Ensembl: ENSG000001046607   OMIM: 6073385   UniProtKB: O952143   

Export aliases for LEPROTL1 gene to outside databases

Previous GC identifers: GC08P029868 GC08P030404 GC08P030072 GC08P028497


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LERL1_HUMAN, O95214
Function: Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver
resistance to GH during periods of reduced nutrient availability




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LEPROTL1 gene promoter:
         RP58   Tal-1   MEF-2   XBP-1   CUTL1   Tal-1beta   E47   MEF-2A   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLEPROTL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LEPROTL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LEPROTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p21

LEPROTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LEPROTL1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P030010:  view genomic region     (about GC identifiers)

Start:
29,952,914 bp from pter      End:
30,034,724 bp from pter
Size:
81,811 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LERL1_HUMAN, O95214 (See protein sequence)
Recommended Name: Leptin receptor overlapping transcript-like 1  
Size: 131 amino acids; 14428 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: E9PHP8 Q9BW48
Alternative splicing: 2 isoforms:  O95214-1   O95214-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LEPROTL1: NX_O95214

LEPROTL1 Protein expression data from MOPED and PaxDb:    About this image 
LEPROTL1 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001121680.1  NP_056159.2  

ENSEMBL proteins: 
 ENSP00000314625   ENSP00000430702   ENSP00000429656   ENSP00000412803   ENSP00000428281  
 ENSP00000429398   ENSP00000428196   ENSP00000429155  

Human Recombinant Protein Products for LEPROTL1: 
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OriGene Protein Over-expression Lysate: LEPROTL1
OriGene Custom Protein Services for LEPROTL1 
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Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for LEPROTL1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

LEPROTL1 for ontologies           About GeneDecksing



LEPROTL1 Antibody Products: 
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Novus Biologicals LEPROTL1 Antibody
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Uscn Antibodies for LEPROTL1
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Uscn ELISAs and CLIAs for LEPROTL1


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LEPROTL1 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR007262 VPS55

Graphical View of Domain Structure for InterPro Entry O95214

ProtoNet protein and cluster: O95214

1 Blocks protein family: IPB007262 Vacuolar protein sorting 55

UniProtKB/Swiss-Prot: LERL1_HUMAN, O95214
Similarity: Belongs to the OB-RGRP/VPS55 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: LERL1_HUMAN, O95214
Function: Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver
resistance to GH during periods of reduced nutrient availability

Phenotypes:
     3 GenomeRNAi human phenotypes for LEPROTL1:

 G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

     1 MGI phenotypic allele for Leprotl1 (no phenotypes)

LEPROTL1 for phenotypes           About GeneDecksing

Animal Models:
     Mouse knock-out Leprotl1tm1Lex for LEPROTL1
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LEPROTL1 

miRNA
Products:
    
OriGene 3'-UTR Clone (see all 2): LEPROTL1
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LEPROTL1
8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate LEPROTL1 (see all 40):
hsa-miR-4291 hsa-let-7d hsa-miR-1197 hsa-miR-199a-3p hsa-miR-3921 hsa-miR-500a hsa-miR-3142 hsa-let-7g
SwitchGear 3'UTR luciferase reporter plasmidLEPROTL1 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LEPROTL1 (see all 7)
OriGene shRNA RFP: LEPROTL1
OriGene siRNA: LEPROTL1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LEPROTL1
Sirion Biotech Custom design and validation of potent shRNA sequences against LEPROTL1 

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for LEPROTL1
Sirion Biotech Customized adenovirus for overexpression of LEPROTL1 
Sirion Biotech Customized adenovirus for potent knockdown of LEPROTL1

Clone
Products:
     
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LEPROTL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LEPROTL1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 2): LEPROTL1 (NM_015344)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LEPROTL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEPROTL1 

Cell Line
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Search LifeMap BioReagents cell lines for LEPROTL1
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Sirion Biotech Customized stable overexpressing cell line services for LEPROTL1
Sirion Biotech Customized inducible overexpressing cell line services for LEPROTL1

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEPROTL1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LEPROTL1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for LEPROTL1 (O952142, 3 ENSP000004128034) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
KLRG1Q96E932, 3, ENSP000003494774MINT-67902 I2D: score=4 STRING: ENSP00000349477
MAFAENSP000003283644STRING: ENSP00000328364
ELAVL1ENSP000003852694STRING: ENSP00000385269
LEPENSP000003126524STRING: ENSP00000312652
MAK16ENSP000003532464STRING: ENSP00000353246
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LEPROTL1
Search CenterWatch for drugs/clinical trials and news about LEPROTL1 / LERL1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LEPROTL1 gene (2 alternative transcripts): 
NM_001128208.1  NM_015344.2  

Unigene Cluster for LEPROTL1:

Leptin receptor overlapping transcript-like 1
Hs.146585  [show with all ESTs]
Unigene Representative Sequence: NM_015344
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000321250(uc003xhw.4) ENST00000518001 ENST00000520682 ENST00000442880(uc003xhx.2)
ENST00000523116 ENST00000520739 ENST00000518192 ENST00000519466

miRNA
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OriGene 3'-UTR Clone (see all 2): LEPROTL1
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LEPROTL1
8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate LEPROTL1 (see all 40):
hsa-miR-4291 hsa-let-7d hsa-miR-1197 hsa-miR-199a-3p hsa-miR-3921 hsa-miR-500a hsa-miR-3142 hsa-let-7g
SwitchGear 3'UTR luciferase reporter plasmidLEPROTL1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LEPROTL1 (see all 7)
OriGene shRNA RFP: LEPROTL1
OriGene siRNA: LEPROTL1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LEPROTL1
Sirion Biotech Custom design and validation of potent shRNA sequences against LEPROTL1 
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LEPROTL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LEPROTL1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 2): LEPROTL1 (NM_015344)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LEPROTL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEPROTL1 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LEPROTL1
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LEPROTL1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LEPROTL1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LEPROTL1

Additional cDNA sequence: 

AF063605.1 AF161461.1 AK075363.1 AY277595.1 AY358674.1 BC000642.2 CR541735.1 CR541760.1 

17 DOTS entries:

DT.318097  DT.120629856  DT.100796782  DT.102840418  DT.92441997  DT.40191742  DT.439715  DT.120629855 
DT.120629874  DT.120629881  DT.92441996  DT.92441998  DT.95071145  DT.95276387  DT.95276390  DT.120629894 
DT.40191096 

24/323 AceView cDNA sequences (see all 323):

CF139791 AA977564 BQ185856 CB529283 CB114693 AA974763 AW516232 BU146006 
BU187597 CR620833 BM691171 BM470683 BQ184170 AL542540 AI951749 N95735 
BM549093 BP342444 CF529998 AU280455 BC000642 CD368099 BM724493 BG254887 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LEPROTL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGCAACAC
LEPROTL1 Expression
About this image
See LEPROTL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LEPROTL1

SOURCE GeneReport for Unigene cluster: Hs.146585

UniProtKB/Swiss-Prot: LERL1_HUMAN, O95214
Tissue specificity: Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and
lowest expression in lung and skeletal muscle

    SABiosciences Custom PCR Arrays for LEPROTL1
Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LEPROTL1
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LEPROTL1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LEPROTL1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEPROTL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LEPROTL1 gene from 6/23 species (see all 23)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Leprotl11 , 5 leptin receptor overlapping transcript-like 11, 5 89.06(n)1
98.47(a)1
  8 (20.90 cM)5
681921  NM_026609.21  NP_080885.11 
 341355725 
chicken
(Gallus gallus)
Aves LEPROTL11 leptin receptor overlapping transcript-like 1 84.73(n)
94.66(a)
  422625  XM_420582.3  XP_420582.1 
African clawed frog
(Xenopus laevis)
Amphibia Xl.289722 Xenopus laevis transcribed sequence with moderate similarity more 79.91(n)    BQ733270.1 
zebrafish
(Danio rerio)
Actinopterygii wufb95c072 Transcribed sequence with moderate similarity to protein more 75.22(n)    CD596943.1 
fruit fly
(Drosophila melanogaster)
Insecta CG304236
--
37(a)
1 → many
2R(20762499-20763388)
worm
(Caenorhabditis elegans)
Secernentea C30B5.21 Protein C30B5.2 54.33(n)
51.97(a)
  174028  NM_062838.3  NP_495239.2 


ENSEMBL Gene Tree for LEPROTL1 (if available)
TreeFam Gene Tree for LEPROTL1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for LEPROTL1 gene
LEPROT2  
18/42 SIMAP similar genes for LEPROTL1 using alignment to 8 protein entries:     LERL1_HUMAN (see all proteins) (see all similar genes):
LEPROT    APOPT1    NFS1    LOC100506792    SPATS2L    FAM210A
ZNF283    BTBD2    C4orf22    NF2    TMEM14B    AURA2
ERBB2    LYRM4    ZNF212    CFLAR    HMGA2    UTY

LEPROTL1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/778 NCBI SNPs in LEPROTL1 are shown (see all 778    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs752966431,2
C--28498474(+) TTTCCC/TTTTTT 1 -- int11Minor allele frequency- T:0.50NA 2
rs1899962281,2
--29951156(+) TCCCAA/CGTAGC 2 -- us2k10--------
rs1817079851,2
--29951274(+) TCCTCC/TTGTCT 2 -- us2k10--------
rs1862082811,2
--29951302(+) GGGATC/GACATG 2 -- us2k10--------
rs1909794261,2
--29951337(+) AAGTGC/GCATAT 2 -- us2k10--------
rs1462156721,2
--29951364(+) CTGATC/TCCCTT 2 -- us2k10--------
rs1423990431,2
C--29951406(+) TTTTT-/TGTGTGT 2 -- us2k10--------
rs1390441051,2
--29951465(+) AGCGTC/GTAACC 2 -- us2k10--------
rs121141471,2
C,F,H--29951606(+) TTTCTA/GTTAAA 2 -- us2k1 tfbs39Minor allele frequency- G:0.03NS EA NA WA 1110
rs2001380521,2
--29951762(+) AGAGG-/AAAAGG 2 -- us2k10--------

HapMap Linkage Disequilibrium report for LEPROTL1 (29952914 - 30034724 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for LEPROTL1: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LEPROTL1
DNA2.0 Custom Variant and Variant Library Synthesis for LEPROTL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LEPROTL1 for disorders           About GeneDecksing

OMIM gene information: 607338    OMIM disorders: --

2 diseases for LEPROTL1:    About MalaCards
obesity    hepatitis

Human Genome Epidemiology (HuGE) Navigator: LEPROTL1 (2 documents)

Export disorders for LEPROTL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for LEPROTL1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with LEPROTL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1). (PubMed id 11342119)1, 2, 3, 9 Huang Y.... Mao Y.M. (2001)
  2. LEPROT and LEPROTL1 cooperatively decrease hepatic gr owth hormone action in mice. (PubMed id 19907080)1, 2 Touvier T....Bailleul B. (2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1 He C....Hunter D.J. (2010)
  6. Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Stud y. (PubMed id 19876004)1 Corpeleijn E....Blaak E.E. (2009)
  7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  9. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
  10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 23484 HGNC: 6555 AceView: LEPROTL1 Ensembl:ENSG00000104660 euGenes: HUgn23484
ECgene: LEPROTL1 H-InvDB: LEPROTL1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for LEPROTL1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for LEPROTL1 gene:
Search GeneIP for patents involving LEPROTL1

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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 Browse OriGene Antibodies   OriGene shRNA RFP for LEPROTL1  
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 OriGene Custom Antibody Services for LEPROTL1   OriGene Custom Protein Services for LEPROTL1  
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 Regulatory tfbs in LEPROTL1 promoter
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 LEPROTL1 Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for LEPROTL1
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEPROTL1
 inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LEPROTL1
Sirion Biotech Customized:
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 design and validation of potent shRNA sequences against LEPROTL1
 adenovirus for potent knockdown of LEPROTL1
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 stable overexpressing cell line services for LEPROTL1
 inducible overexpressing cell line services for LEPROTL1
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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VWF
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von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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