Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LEPROT Gene

Aliases for LEPROT Gene

  • Leptin Receptor Overlapping Transcript 2 3 5
  • Leptin Receptor Overlapping Transcript Protein 3 4
  • OB-R Gene-Related Protein 3 4
  • Endospanin-1 3 4
  • OB-RGRP 3 4
  • LEPR 3 4
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 6 3
  • Leptin Receptor Gene Related Protein 2
  • Leptin Receptor Gene-Related Protein 3
  • OBRGRP 3
  • VPS55 3
  • OBR 4

External Ids for LEPROT Gene

Previous GeneCards Identifiers for LEPROT Gene

  • GC01P065600
  • GC01P065658
  • GC01P065887
  • GC01P063996

Summaries for LEPROT Gene

Entrez Gene Summary for LEPROT Gene

  • LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]

GeneCards Summary for LEPROT Gene

LEPROT (Leptin Receptor Overlapping Transcript) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is LEPROTL1.

UniProtKB/Swiss-Prot for LEPROT Gene

  • Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEPROT Gene

Genomics for LEPROT Gene

Regulatory Elements for LEPROT Gene

Enhancers for LEPROT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F065416 1.7 FANTOM5 Ensembl ENCODE 39.6 +1.4 1398 9.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS LEPROT LEPR ENSG00000237852
GH01F065467 1.2 Ensembl ENCODE 16.2 +47.4 47352 0.4 MLX ARID4B ZNF48 KLF7 SP5 MXD4 MIER2 PPARG KAT8 MIER3 LEPROT LEPR ENSG00000237852
GH01F065265 1.3 FANTOM5 ENCODE 11.1 -154.4 -154430 1.3 PKNOX1 KLF17 ARID4B SIN3A DMAP1 ZNF48 ZNF2 RAD21 CHAMP1 GLIS2 LINC01359 DNAJC6 ENSG00000272506 RNU2-15P LEPR LEPROT GC01M065252 COX6CP13
GH01F065687 1.3 Ensembl ENCODE 10.4 +267.4 267379 1.2 ATF1 PKNOX1 ARID4B FEZF1 ZNF2 GATA2 DEK ZNF263 MXD4 MIER2 LEPR LEPROT RNU2-15P AK4 GC01P065638 GC01M065708
GH01F065229 1 ENCODE 11 -188.8 -188798 5.0 PKNOX1 ARNT FEZF1 YY1 ZNF121 GATA2 JUNB NCOA1 MIER2 REST AK4 JAK1 LEPR LEPROT GC01P065229 DNAJC6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LEPROT on UCSC Golden Path with GeneCards custom track

Promoters for LEPROT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001521203 352 2801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13

Transcription factor binding sites by QIAGEN in the LEPROT gene promoter:

Genomic Location for LEPROT Gene

Chromosome:
1
Start:
65,420,448 bp from pter
End:
65,436,007 bp from pter
Size:
15,560 bases
Orientation:
Plus strand

Genomic View for LEPROT Gene

Genes around LEPROT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEPROT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEPROT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEPROT Gene

Proteins for LEPROT Gene

  • Protein details for LEPROT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15243-OBRG_HUMAN
    Recommended name:
    Leptin receptor gene-related protein
    Protein Accession:
    O15243
    Secondary Accessions:
    • Q6FHL5

    Protein attributes for LEPROT Gene

    Size:
    131 amino acids
    Molecular mass:
    14254 Da
    Quaternary structure:
    • Interacts with LEPR. Interacts with RAB13 (By similarity).

neXtProt entry for LEPROT Gene

Post-translational modifications for LEPROT Gene

No Post-translational modifications

Other Protein References for LEPROT Gene

No data available for DME Specific Peptides for LEPROT Gene

Domains & Families for LEPROT Gene

Protein Domains for LEPROT Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LEPROT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15243

UniProtKB/Swiss-Prot:

OBRG_HUMAN :
  • Belongs to the OB-RGRP/VPS55 family.
Family:
  • Belongs to the OB-RGRP/VPS55 family.
genes like me logo Genes that share domains with LEPROT: view

No data available for Gene Families for LEPROT Gene

Function for LEPROT Gene

Molecular function for LEPROT Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

Gene Ontology (GO) - Molecular Function for LEPROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA 18042720
genes like me logo Genes that share ontologies with LEPROT: view
genes like me logo Genes that share phenotypes with LEPROT: view

Animal Models for LEPROT Gene

MGI Knock Outs for LEPROT:

Animal Model Products

miRNA for LEPROT Gene

miRTarBase miRNAs that target LEPROT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LEPROT Gene

Localization for LEPROT Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEPROT Gene

Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LEPROT gene
Compartment Confidence
golgi apparatus 5
endosome 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for LEPROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome IEA,IDA 18042720
GO:0005794 Golgi apparatus IEA,IDA 18042720
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LEPROT: view

Pathways & Interactions for LEPROT Gene

SuperPathways for LEPROT Gene

No Data Available

Gene Ontology (GO) - Biological Process for LEPROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway IBA --
GO:0046426 negative regulation of JAK-STAT cascade IDA 18042720
GO:0060400 negative regulation of growth hormone receptor signaling pathway IDA 19907080
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
GO:2000009 negative regulation of protein localization to cell surface IDA 18042720
genes like me logo Genes that share ontologies with LEPROT: view

No data available for Pathways by source and SIGNOR curated interactions for LEPROT Gene

Transcripts for LEPROT Gene

Unigene Clusters for LEPROT Gene

Leptin receptor overlapping transcript:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LEPROT Gene

No ASD Table

Relevant External Links for LEPROT Gene

GeneLoc Exon Structure for
LEPROT
ECgene alternative splicing isoforms for
LEPROT

Expression for LEPROT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LEPROT Gene

Protein differential expression in normal tissues from HIPED for LEPROT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6), Pancreas (12.5), and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LEPROT Gene



NURSA nuclear receptor signaling pathways regulating expression of LEPROT Gene:

LEPROT

SOURCE GeneReport for Unigene cluster for LEPROT Gene:

Hs.23581

mRNA Expression by UniProt/SwissProt for LEPROT Gene:

O15243-OBRG_HUMAN
Tissue specificity: Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with LEPROT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for LEPROT Gene

Orthologs for LEPROT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LEPROT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LEPROT 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LEPROT 35
  • 98 (a)
OneToOne
LOC609115 34
  • 93.38 (n)
cow
(Bos Taurus)
Mammalia LEPROT 35 34
  • 92.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Leprot 34 16 35
  • 89.06 (n)
rat
(Rattus norvegicus)
Mammalia Leprot 34
  • 89.06 (n)
oppossum
(Monodelphis domestica)
Mammalia LEPROT 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LEPROT 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves LEPROT 34 35
  • 79.39 (n)
lizard
(Anolis carolinensis)
Reptilia LEPROT 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia leprot 34
  • 75.83 (n)
zebrafish
(Danio rerio)
Actinopterygii leprot 34
  • 70 (n)
LEPROT 35
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30423 35
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30B5.2 35
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS55 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToMany
Species where no ortholog for LEPROT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LEPROT Gene

ENSEMBL:
Gene Tree for LEPROT (if available)
TreeFam:
Gene Tree for LEPROT (if available)

Paralogs for LEPROT Gene

Paralogs for LEPROT Gene

(1) SIMAP similar genes for LEPROT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LEPROT: view

Variants for LEPROT Gene

Sequence variations from dbSNP and Humsavar for LEPROT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1045895 -- 65,432,298(+) AGGCC(A/G)GGGTG intron-variant, utr-variant-3-prime
rs1046011 -- 65,433,313(-) CTACA(A/G)GACGG intron-variant, utr-variant-3-prime
rs10889549 -- 65,422,402(+) GCCTT(A/C)AGAGG intron-variant
rs111472430 -- 65,420,001(+) GGGAG(A/C)GACTC upstream-variant-2KB
rs111723465 -- 65,422,918(+) GTAGA(A/G)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LEPROT Gene

Variant ID Type Subtype PubMed ID
dgv174n100 CNV gain 25217958
nsv528808 CNV gain 19592680
nsv546438 CNV gain 21841781
nsv830070 CNV gain 17160897
nsv830081 CNV gain 17160897
nsv997944 CNV gain 25217958

Variation tolerance for LEPROT Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LEPROT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LEPROT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEPROT Gene

Disorders for LEPROT Gene

Relevant External Links for LEPROT

Genetic Association Database (GAD)
LEPROT
Human Genome Epidemiology (HuGE) Navigator
LEPROT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEPROT

No disorders were found for LEPROT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEPROT Gene

Publications for LEPROT Gene

  1. The leptin receptor promoter controls expression of a second distinct protein. (PMID: 9207021) Bailleul B. … Strosberg A.D. (Nucleic Acids Res. 1997) 2 3 4 22 64
  2. LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. (PMID: 19907080) Touvier T. … Bailleul B. (J. Clin. Invest. 2009) 3 4 22 64
  3. Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. (PMID: 18042720) Couturier C. … Jockers R. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 22 64
  4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 46 64
  5. Copy number variation at leptin receptor gene locus associated with metabolic traits and the risk of type 2 diabetes mellitus. (PMID: 20624279) Jeon J.P. … Han B.G. (BMC Genomics 2010) 3 46 64

Products for LEPROT Gene

Sources for LEPROT Gene

Content
Loading form....