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Aliases for LEPROT Gene

Aliases for LEPROT Gene

  • Leptin Receptor Overlapping Transcript 2 3 5
  • Leptin Receptor Overlapping Transcript Protein 3 4
  • Leptin Receptor Gene Related Protein 2 3
  • OB-R Gene-Related Protein 3 4
  • Endospanin-1 3 4
  • OB-RGRP 3 4
  • LEPR 3 4
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 6 3
  • OBRGRP 3
  • VPS55 3
  • OBR 4

External Ids for LEPROT Gene

Previous GeneCards Identifiers for LEPROT Gene

  • GC01P065600
  • GC01P065658
  • GC01P065887
  • GC01P063996

Summaries for LEPROT Gene

Entrez Gene Summary for LEPROT Gene

  • LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]

GeneCards Summary for LEPROT Gene

LEPROT (Leptin Receptor Overlapping Transcript) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Development_Leptin signaling via PI3K-dependent pathway. GO annotations related to this gene include receptor binding. An important paralog of this gene is LEPROTL1.

UniProtKB/Swiss-Prot for LEPROT Gene

  • Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEPROT Gene

Genomics for LEPROT Gene

Regulatory Elements for LEPROT Gene

Promoters for LEPROT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LEPROT on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LEPROT gene promoter:

Genomic Location for LEPROT Gene

Chromosome:
1
Start:
65,420,448 bp from pter
End:
65,436,007 bp from pter
Size:
15,560 bases
Orientation:
Plus strand

Genomic View for LEPROT Gene

Genes around LEPROT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEPROT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEPROT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEPROT Gene

Proteins for LEPROT Gene

  • Protein details for LEPROT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15243-OBRG_HUMAN
    Recommended name:
    Leptin receptor gene-related protein
    Protein Accession:
    O15243
    Secondary Accessions:
    • Q6FHL5

    Protein attributes for LEPROT Gene

    Size:
    131 amino acids
    Molecular mass:
    14254 Da
    Quaternary structure:
    • Interacts with LEPR. Interacts with RAB13 (By similarity).

neXtProt entry for LEPROT Gene

Proteomics data for LEPROT Gene at MOPED

Post-translational modifications for LEPROT Gene

No Post-translational modifications

Other Protein References for LEPROT Gene

No data available for DME Specific Peptides for LEPROT Gene

Domains & Families for LEPROT Gene

Protein Domains for LEPROT Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LEPROT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15243

UniProtKB/Swiss-Prot:

OBRG_HUMAN :
  • Belongs to the OB-RGRP/VPS55 family.
Family:
  • Belongs to the OB-RGRP/VPS55 family.
genes like me logo Genes that share domains with LEPROT: view

No data available for Gene Families for LEPROT Gene

Function for LEPROT Gene

Molecular function for LEPROT Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

Gene Ontology (GO) - Molecular Function for LEPROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA 18042720
genes like me logo Genes that share ontologies with LEPROT: view
genes like me logo Genes that share phenotypes with LEPROT: view

Animal Models for LEPROT Gene

MGI Knock Outs for LEPROT:

Animal Model Products

miRNA for LEPROT Gene

miRTarBase miRNAs that target LEPROT

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LEPROT Gene

Localization for LEPROT Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEPROT Gene

Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LEPROT Gene COMPARTMENTS Subcellular localization image for LEPROT gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for LEPROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome IDA 18042720
genes like me logo Genes that share ontologies with LEPROT: view

Pathways & Interactions for LEPROT Gene

genes like me logo Genes that share pathways with LEPROT: view

Interacting Proteins for LEPROT Gene

Gene Ontology (GO) - Biological Process for LEPROT Gene

None

No data available for SIGNOR curated interactions for LEPROT Gene

Drugs & Compounds for LEPROT Gene

No Compound Related Data Available

Transcripts for LEPROT Gene

Unigene Clusters for LEPROT Gene

Leptin receptor overlapping transcript:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LEPROT Gene

No ASD Table

Relevant External Links for LEPROT Gene

GeneLoc Exon Structure for
LEPROT
ECgene alternative splicing isoforms for
LEPROT

Expression for LEPROT Gene

mRNA expression in normal human tissues for LEPROT Gene

Protein differential expression in normal tissues from HIPED for LEPROT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6), Pancreas (12.5), and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LEPROT Gene



SOURCE GeneReport for Unigene cluster for LEPROT Gene Hs.23581

mRNA Expression by UniProt/SwissProt for LEPROT Gene

O15243-OBRG_HUMAN
Tissue specificity: Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with LEPROT: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for LEPROT Gene

Orthologs for LEPROT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LEPROT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LEPROT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LEPROT 36
  • 98 (a)
OneToOne
LEPROT 35
  • 92.62 (n)
  • 97.71 (a)
dog
(Canis familiaris)
Mammalia LOC609115 35
  • 93.38 (n)
  • 97.71 (a)
LEPROT 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Leprot 16
Leprot 35
  • 89.06 (n)
  • 94.66 (a)
Leprot 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LEPROT 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LEPROT 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Leprot 35
  • 89.06 (n)
  • 96.95 (a)
chicken
(Gallus gallus)
Aves LEPROT 35
  • 79.39 (n)
  • 87.79 (a)
LEPROT 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LEPROT 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia leprot 35
  • 75.83 (n)
  • 83.97 (a)
zebrafish
(Danio rerio)
Actinopterygii LEPROT 36
  • 64 (a)
OneToOne
leprot 35
  • 70 (n)
  • 76.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30423 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30B5.2 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS55 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for LEPROT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LEPROT Gene

ENSEMBL:
Gene Tree for LEPROT (if available)
TreeFam:
Gene Tree for LEPROT (if available)

Paralogs for LEPROT Gene

Paralogs for LEPROT Gene

(1) SIMAP similar genes for LEPROT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LEPROT: view

Variants for LEPROT Gene

Sequence variations from dbSNP and Humsavar for LEPROT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs183657291 -- 65,418,459(+) TGTTC(A/G)TATAG upstream-variant-2KB
rs188017293 -- 65,418,592(+) TCTAG(A/G)GGCAG upstream-variant-2KB
rs756699777 -- 65,418,487(+) AGAGA(C/T)AAGCA upstream-variant-2KB
rs565716202 -- 65,418,550(+) AATAA(A/T)TTTTT upstream-variant-2KB
rs780669042 -- 65,418,571(+) CAAGA(G/T)AAAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LEPROT Gene

Variant ID Type Subtype PubMed ID
nsv830070 CNV Gain 17160897
nsv528808 CNV Gain 19592680
nsv830081 CNV Gain 17160897

Variation tolerance for LEPROT Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LEPROT Gene

HapMap Linkage Disequilibrium report
LEPROT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEPROT Gene

Disorders for LEPROT Gene

Relevant External Links for LEPROT

Genetic Association Database (GAD)
LEPROT
Human Genome Epidemiology (HuGE) Navigator
LEPROT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEPROT

No disorders were found for LEPROT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEPROT Gene

Publications for LEPROT Gene

  1. The leptin receptor promoter controls expression of a second distinct protein. (PMID: 9207021) Bailleul B. … Strosberg A.D. (Nucleic Acids Res. 1997) 2 3 4 23 67
  2. LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. (PMID: 19907080) Touvier T. … Bailleul B. (J. Clin. Invest. 2009) 3 23
  3. Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. (PMID: 18042720) Couturier C. … Jockers R. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3
  5. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3

Products for LEPROT Gene

Sources for LEPROT Gene

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