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Aliases for LEPROT Gene

Aliases for LEPROT Gene

  • Leptin Receptor Overlapping Transcript 2 3
  • Leptin Receptor Overlapping Transcript Protein 3 4
  • Leptin Receptor Gene Related Protein 2 3
  • OB-R Gene-Related Protein 3 4
  • Endospanin-1 3 4
  • OB-RGRP 3 4
  • LEPR 3 4
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 6 3
  • OBRGRP 3
  • VPS55 3
  • OBR 4

External Ids for LEPROT Gene

Previous GeneCards Identifiers for LEPROT Gene

  • GC01P065600
  • GC01P065658
  • GC01P065887
  • GC01P063996

Summaries for LEPROT Gene

Entrez Gene Summary for LEPROT Gene

  • LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]

GeneCards Summary for LEPROT Gene

LEPROT (Leptin Receptor Overlapping Transcript) is a Protein Coding gene. Diseases associated with LEPROT include obesity. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor binding. An important paralog of this gene is LEPROTL1.

UniProtKB/Swiss-Prot for LEPROT Gene

  • Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEPROT Gene

Genomics for LEPROT Gene

Regulatory Elements for LEPROT Gene

Transcription factor binding sites by QIAGEN in the LEPROT gene promoter:

Genomic Location for LEPROT Gene

Chromosome:
1
Start:
65,420,448 bp from pter
End:
65,436,007 bp from pter
Size:
15,560 bases
Orientation:
Plus strand

Genomic View for LEPROT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LEPROT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEPROT Gene

Proteins for LEPROT Gene

  • Protein details for LEPROT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15243-OBRG_HUMAN
    Recommended name:
    Leptin receptor gene-related protein
    Protein Accession:
    O15243
    Secondary Accessions:
    • Q6FHL5

    Protein attributes for LEPROT Gene

    Size:
    131 amino acids
    Molecular mass:
    14254 Da
    Quaternary structure:
    • Interacts with LEPR. Interacts with RAB13 (By similarity).

neXtProt entry for LEPROT Gene

Proteomics data for LEPROT Gene at MOPED

Post-translational modifications for LEPROT Gene

No Post-translational modifications

Other Protein References for LEPROT Gene

No data available for DME Specific Peptides for LEPROT Gene

Domains & Families for LEPROT Gene

Protein Domains for LEPROT Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LEPROT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15243

UniProtKB/Swiss-Prot:

OBRG_HUMAN :
  • Belongs to the OB-RGRP/VPS55 family.
Family:
  • Belongs to the OB-RGRP/VPS55 family.
genes like me logo Genes that share domains with LEPROT: view

No data available for Gene Families for LEPROT Gene

Function for LEPROT Gene

Molecular function for LEPROT Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.

Gene Ontology (GO) - Molecular Function for LEPROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA 18042720
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LEPROT: view

Phenotypes for LEPROT Gene

genes like me logo Genes that share phenotypes with LEPROT: view

Animal Model Products

miRNA for LEPROT Gene

miRTarBase miRNAs that target LEPROT

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LEPROT

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LEPROT Gene

Localization for LEPROT Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEPROT Gene

Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LEPROT Gene COMPARTMENTS Subcellular localization image for LEPROT gene
Compartment Confidence
endosome 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for LEPROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome IDA 18042720
GO:0005794 Golgi apparatus IDA 18042720
GO:0010008 endosome membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LEPROT: view

Pathways & Interactions for LEPROT Gene

genes like me logo Genes that share pathways with LEPROT: view

Interacting Proteins for LEPROT Gene

Gene Ontology (GO) - Biological Process for LEPROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046426 negative regulation of JAK-STAT cascade IDA 18042720
GO:0060400 negative regulation of growth hormone receptor signaling pathway IDA 19907080
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
GO:2000009 negative regulation of protein localization to cell surface IDA 18042720
genes like me logo Genes that share ontologies with LEPROT: view

No data available for SIGNOR curated interactions for LEPROT Gene

Drugs & Compounds for LEPROT Gene

No Compound Related Data Available

Transcripts for LEPROT Gene

Unigene Clusters for LEPROT Gene

Leptin receptor overlapping transcript:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LEPROT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LEPROT Gene

No ASD Table

Relevant External Links for LEPROT Gene

GeneLoc Exon Structure for
LEPROT
ECgene alternative splicing isoforms for
LEPROT

Expression for LEPROT Gene

mRNA expression in normal human tissues for LEPROT Gene

Protein differential expression in normal tissues from HIPED for LEPROT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6), Pancreas (12.5), and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LEPROT Gene



SOURCE GeneReport for Unigene cluster for LEPROT Gene Hs.23581

mRNA Expression by UniProt/SwissProt for LEPROT Gene

O15243-OBRG_HUMAN
Tissue specificity: Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expression patterns with LEPROT: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for LEPROT Gene

Orthologs for LEPROT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LEPROT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LEPROT 35
  • 92.62 (n)
  • 97.71 (a)
LEPROT 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC609115 35
  • 93.38 (n)
  • 97.71 (a)
LEPROT 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Leprot 35
  • 89.06 (n)
  • 94.66 (a)
Leprot 16
Leprot 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Leprot 35
  • 89.06 (n)
  • 96.95 (a)
oppossum
(Monodelphis domestica)
Mammalia LEPROT 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LEPROT 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LEPROT 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves LEPROT 35
  • 79.39 (n)
  • 87.79 (a)
LEPROT 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LEPROT 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia leprot 35
  • 75.83 (n)
  • 83.97 (a)
zebrafish
(Danio rerio)
Actinopterygii leprot 35
  • 70 (n)
  • 76.15 (a)
LEPROT 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30423 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30B5.2 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS55 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for LEPROT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LEPROT Gene

ENSEMBL:
Gene Tree for LEPROT (if available)
TreeFam:
Gene Tree for LEPROT (if available)

Paralogs for LEPROT Gene

Paralogs for LEPROT Gene

(1) SIMAP similar genes for LEPROT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LEPROT: view

Variants for LEPROT Gene

Sequence variations from dbSNP and Humsavar for LEPROT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs34611559 -- 65,418,518(+) TTGGG(-/G)TTTAT upstream-variant-2KB
rs183657291 -- 65,418,459(+) TGTTC(A/G)TATAG upstream-variant-2KB
rs188017293 -- 65,418,592(+) TCTAG(A/G)GGCAG upstream-variant-2KB
rs376540612 -- 65,418,619(+) AAATA(C/T)ATGGG upstream-variant-2KB
rs565716202 -- 65,418,550(+) AATAA(A/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LEPROT Gene

Variant ID Type Subtype PubMed ID
nsv830070 CNV Gain 17160897
nsv528808 CNV Gain 19592680
nsv830081 CNV Gain 17160897

Variation tolerance for LEPROT Gene

Residual Variation Intolerance Score: 46.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LEPROT Gene

HapMap Linkage Disequilibrium report
LEPROT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEPROT Gene

Disorders for LEPROT Gene

MalaCards: The human disease database

(1) MalaCards diseases for LEPROT Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association

Relevant External Links for LEPROT

Genetic Association Database (GAD)
LEPROT
Human Genome Epidemiology (HuGE) Navigator
LEPROT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEPROT
genes like me logo Genes that share disorders with LEPROT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LEPROT Gene

Publications for LEPROT Gene

  1. The leptin receptor promoter controls expression of a second distinct protein. (PMID: 9207021) Bailleul B. … Strosberg A.D. (Nucleic Acids Res. 1997) 2 23 67
  2. Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers. (PMID: 19443042) Lalovic A. … Turecki G. (J Affect Disord 2010) 23 67
  3. Immunohistochemical studies on early stage of hepatic damage induced by subacute inhalation of toluene vapor in rats. (PMID: 19391120) Gotohda T. … Morita K. (J Appl Toxicol 2009) 23 67
  4. Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells. (PMID: 19553602) PAcrez-PAcrez A. … SA!nchez-Margalet V. (Biol. Reprod. 2009) 23 67
  5. [Expression, distribution and biological function of leptin receptor in the testis]. (PMID: 19593999) Gao L. … Chen B. (Zhonghua Nan Ke Xue 2009) 23 67

Products for LEPROT Gene

Sources for LEPROT Gene

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