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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LEP Gene

protein-coding GIFtS: 68
GCID: GC07P127881

leptin

(Previous names: leptin (murine obesity homolog), leptin (obesity homolog,...)
(Previous symbols: OBS, OB)

Explore 280 diseases affiliated with
LEP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leptin¹		Obese Protein² ³
OB¹ ² ³ ⁵		Obesity Factor² ³
OBS¹ ² ³		LEPD²
Leptin (Murine Obesity Homolog)¹ ²		Obese, Mouse, Homolog Of²
Leptin (Obesity Homolog, Mouse)¹ ²

External Ids:	HGNC: 6553¹	Entrez Gene: 3952²	Ensembl: ENSG00000174697⁷	OMIM: 164160⁵	UniProtKB: P41159³

Export aliases for LEP gene to outside databases

Previous GC identifers: GC07P126358 GC07P127421 GC07P127435 GC07P127475 GC07P127668 GC07P122242

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LEP:

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of

body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can

inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also

has several endocrine functions, and is involved in the regulation of immune and inflammatory responses,

hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe

obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159

Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase

in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy

expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

summary for LEP:

Leptin was initially thought to have a role in energy homeostasis and obesity. More recently, it has also

been implicated in the regulation of reproduction, glucose homeostasis, bone formation, wound healing and

the immune system. Leptin acts via leptin receptors, which are transmembrane catalytic receptors found on

NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one

human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at

physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so

through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates

transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid

expression. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese

individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier)

expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are

of great interest in the development of pharmacological treatments for obesity.

Gene Wiki entry for LEP (Leptin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LEP gene promoter:
GR C/EBPbeta AP-1 ATF-2 GR-beta AP-2gamma AREB6 GR-alpha c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): LEP promoter sequence

Search SABiosciences Chromatin IP Primers for LEP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LEP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3 Ensembl cytogenetic band: 7q32.1 HGNC cytogenetic band: 7q31

LEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LEP gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P127881: view genomic region (about GC identifiers)

Start:	127,881,331 bp from pter	End:	127,897,682 bp from pter
Size:	16,352 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 127,264,455-127,280,803

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159 (See protein sequence)

Recommended Name: Leptin precursor

Size: 167 amino acids; 18641 Da

Subunit: Interacts with SIGLEC6

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for LEP:

1AX8 (3D)

Secondary accessions: O15158 Q56A88

Explore the universe of human proteins at neXtProt for LEP: NX_P41159

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P41159

LEP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000221.1

ENSEMBL proteins:

ENSP00000312652

Reactome Protein details: P41159
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant LEP Protein
	R&D Systems Recombinant & Natural Proteins for LEP (Leptin/OB)
	Enzo Life Sciences proteins for LEP
	OriGene Purified Protein: LEP OriGene Protein Over-expression Lysate: LEP OriGene Custom Protein Services for LEP
	GenScript Purified and Recombinant Proteins for LEP
	Novus Biologicals LEP Proteins Novus Biologicals LEP Lysate
	Sino Biological Recombinant Protein for LEP
	ProSpec Recombinant Protein for LEP
	Uscn Proteins for LEP

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	ISS	--
GO:0005622	intracellular	--	--

LEP for ontologies About GeneDecksing

LEP Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LEP
	R&D Systems Antibodies for LEP (Leptin/OB)
	Browse OriGene Antibodies OriGene Custom Antibody Services for LEP
	GenScript Superior Antibodies for LEP
	Novus Biologicals LEP Antibodies
	Search for Antibodies for LEP at Abcam
	Uscn Antibodies for LEP
	ThermoFisher Antibody for LEP

Assay Products for LEP:

	EMD Millipore Kits and Assays for the Analysis of LEP
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for LEP (Leptin/OB) (see all)
	GenScript Custom Assay Services for LEP
	Enzo Life Sciences assays for LEP
	Uscn ELISAs and CLIAs for LEP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LEP for domains About GeneDecksing

3 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR009079 4_helix_cytokine-like_core

IPR000065 Leptin

Graphical View of Domain Structure for InterPro Entry P41159

ProtoNet protein and cluster: P41159

1 Blocks protein family: IPB000065 Obesity factor (leptin) signature

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159

Similarity: Belongs to the leptin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159

Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase

in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy

expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

Genatlas biochemistry entry for LEP:

leptin,adipocyte-specific secreted protein,18.6kDa,controlling the size of adipose depot by a profound effect of appen

appetite and energy expenditure,also involved in control of the hypothalamic-pituitary-gonadal (HPG) axis,also

putative angiogenic factor,homolog of the murine obese gene (ob)

Summary:

During embryonic development, LEP as signaling molecule is secreted from the following cells: Subcutaneous White Adipocytes in Cranial Subcutaneous White Adipose, Subcutaneous White Adipocytes in Subcutaneous White Adipose (see all 6).

miRNA Products:		OriGene 3'-UTR Clone: LEP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LEP
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate LEP (see all 24):
		hsa-miR-498 hsa-miR-29a hsa-miR-29c hsa-miR-128 hsa-miR-27b* hsa-miR-9 hsa-miR-1276 hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: LEP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LEP (see all 7) OriGene shRNA RFP: LEP OriGene siRNA: LEP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LEP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LEP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LEP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LEP OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LEP (NM_000230)
		Sino Biological Human cDNA Clone for LEP
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LEP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LEP
		Search LifeMap BioReagents cell lines for LEP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEP

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--
GO:0005515	protein binding	--	--
GO:0008083	growth factor activity	IEA	--
GO:0051428	peptide hormone receptor binding	IEA	--

LEP for ontologies About GeneDecksing

Animal Models:
15/24 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Lep) (see all 24):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging

LEP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_Leptin signaling via PI3K-dependent pathway

	Development Leptin signaling via PI3K-dependent pathway	1.00			Adipocytokine signaling pathway	0.29
	Development_Leptin signaling via PI3K-dependent pathway	1.00

Development_CNTF receptor signaling

Development_Leptin signaling via JAK/STAT and MAPK cascades

0.25

Development Leptin signaling via JAK/STAT and MAPK cascades

0.25

Expression of Leptin

Expression of Leptin

1.00

Transcriptional Regulation of White Adipocyte Differentiation

Transcriptional Regulation of White Adipocyte Differentiation

1.00

Selected targets of GCR-alpha

Selected targets of GCR-alpha

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for LEP

	Development Leptin signaling via JAK/STAT and MAPK cascades
	Selected targets of GCR-alpha
	Development Leptin signaling via PI3K-dependent pathway

1 R&D Systems Pathway for LEP

Adipocytokines & Insulin Signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LEP

AMPK Enzyme Complex Pathway

2 GeneGo (Thomson Reuters) Pathways for LEP

	Development Leptin signaling via JAK/STAT and MAPK cascades
	Development Leptin signaling via PI3K-dependent pathway

5 BioSystems Pathways for LEP

	AMPK signaling
	Adipogenesis
	Leptin signaling pathway
	HIF-1-alpha transcription factor network
	Signaling events mediated by PTP1B

3 Reactome Pathways for LEP

	Expression of Leptin
	Developmental Biology
	Transcriptional Regulation of White Adipocyte Differentiation

4 Kegg Pathways (Kegg details for LEP):

	Cytokine-cytokine receptor interaction
	Neuroactive ligand-receptor interaction
	Jak-STAT signaling pathway
	Adipocytokine signaling pathway

LEP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LEP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for LEP (P41159³ ENSP00000312652⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKAA2	P54646³, ENSP00000360290⁴	I2D: score=1 STRING: ENSP00000360290
UCN	P55089³, ENSP00000296099⁴	I2D: score=1 STRING: ENSP00000296099
LEPR	P48357³, ENSP00000330393⁴	I2D: score=2 STRING: ENSP00000330393
A2M	P01023³, ENSP00000323929⁴	I2D: score=2 STRING: ENSP00000323929
CRP	P02741³, ENSP00000255030⁴	I2D: score=1 STRING: ENSP00000255030

About this table

Gene Ontology (GO): 5/61 biological process terms (GO ID links to tree view) (see all 61): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001542	ovulation from ovarian follicle	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0001819	positive regulation of cytokine production	IEA	--
GO:0001890	placenta development	IDA	17957153

LEP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LEP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for LEP available from Tocris Bioscience About this table

Compound	Action	CAS #
LEP (116-130) (mouse)	Synthetic leptin peptide fragment	[258276-95-8]

1 HMDB Compound for LEP About this table

Compound	Synonyms	CAS #	PubMed Ids
Androstenedione	(4)-Androsten-3,17-dione (see all 14)	63-05-8	11824514

10/130 Novoseek chemical compound relationships for LEP gene (see all 130) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	84.8	1892	10411236 (8), 10411242 (8), 17170237 (7), 15814535 (6) (see all 99)
c-peptide	71.5	169	12752073 (4), 16365005 (4), 19475640 (4), 15196417 (4) (see all 99)
lipid	70.7	531	16737635 (6), 15543224 (5), 11502793 (5), 19169663 (4) (see all 99)
testosterone	70.6	677	18462615 (11), 11244464 (9), 9253326 (7), 11228760 (6) (see all 99)
cholesterol	70.4	648	15555610 (7), 16324751 (7), 11447020 (6), 17884293 (6) (see all 99)
estradiol	67.6	321	9768648 (9), 11791088 (6), 9482922 (5), 11599235 (4) (see all 99)
dehydroepiandrosterone sulfate	63.4	91	10561001 (3), 12647279 (3), 11820328 (2), 17198487 (2) (see all 52)
orlistat	61.4	19	18846024 (3), 20119816 (2), 19409578 (2), 18457636 (1) (see all 6)
fatty acid	61	162	16822822 (4), 11342529 (3), 11404229 (3), 15919610 (3) (see all 99)
metformin	59.5	71	15531718 (6), 11436194 (4), 15983226 (3), 11289473 (3) (see all 37)

2 PharmGKB related drug/compound annotations for LEP gene

Drug/compound	PharmGKB Annotation
olanzapine	CA
risperidone	CA

About this table

Search CenterWatch for drugs/clinical trials and news about LEP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LEP gene:

NM_000230.2

Unigene Cluster for LEP:

Leptin

Hs.194236 [show with all ESTs]

Unigene Representative Sequence: NM_000230

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000308868(uc003vml.2 uc003vmm.2)

miRNA Products:		OriGene 3'-UTR Clone: LEP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LEP
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate LEP (see all 24):
		hsa-miR-498 hsa-miR-29a hsa-miR-29c hsa-miR-128 hsa-miR-27b* hsa-miR-9 hsa-miR-1276 hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: LEP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LEP (see all 7) OriGene shRNA RFP: LEP OriGene siRNA: LEP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LEP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LEP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LEP OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LEP (NM_000230)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LEP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LEP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LEP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LEP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LEP

Additional cDNA sequence:

AF008123.1 AK313553.1 BC060830.1 BC069323.1 BC069452.1 BC069527.1 D49487.1 U18915.1

U43653.1

1 DOTS entry:

DT.412760

24/25 AceView cDNA sequences (see all 25):

U18915 BQ012637 BU752306 U43653 NM_000230 BX479630 BC069323 BC069527

BX098617 AF008123 R62951 BC069452 BC060830 BQ019411 R63003 CB995210

AA320865 N56684 D49487 H42528 H39701 H42529 CB265926 CB995927

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for LEP About this scheme

ExUns:	1a	·	1b	^	2a	·	2b
SP1:
SP2:

ECgene alternative splicing isoforms for LEP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LEP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAAGGGAC

About this image

LEP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Adipocytes

Selective marker (cell-identifying gene)

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Visceral White Adipose

Visceral White Adipocytes

Adipose

Cervical Brown Adipose Depot

Cervical Brown Adipocyte Cells

Adipose

Lumbar Brown Adipose Depot

Lumbar Brown Adipocyte Cells

Adipose

Sacral Brown Adipose Depot

Sacral Brown Adipocyte Cells

Adipose

Thoracic Brown Adipose Depot

Thoracic Brown Adipocyte Cells

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LEP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LEP

SOURCE GeneReport for Unigene cluster: Hs.194236

SABiosciences Expression via Pathway-Focused PCR Arrays including LEP (see all 10):

Insulin Signaling Pathway in human mouse rat

Growth Factors in human mouse rat

Angiogenic Growth Factors in human mouse rat

Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

Angiogenesis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LEP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LEP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LEP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LEP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for LEP gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lep^{1 , 5}	leptin^{1, 5}	82.63(n)¹ 83.23(a)¹		6 (12.30 cM)⁵ 16846¹ NM_008493.3¹ NP_032519.1¹ 29060220⁵

ENSEMBL Gene Tree for LEP (if available)
TreeFam Gene Tree for LEP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs791616^1,2	C,F,A,H,	--	127262467(+)	`tcctaC/Tgcaat`	1	--	us2k¹		7		EA NS NA WA	540
rs61153576^1,2	C,	--	127262468(+)	`CCTACG/ACAATG`	1	--	us2k¹		2		WA	120
rs28954369^1,2	C,F,	--	127262568(+)	`CAGACC/TAGTTT`	1	--	us2k¹		5		NS NA	218
rs28954371^1,2	C,F,	--	127262632(+)	`TGCACC/TGCTGA`	1	--	us2k¹		4		NS NA	98
rs791617^1,2	C,H,	--	127262633(+)	`gcaccG/Tctgaa`	1	--	us2k¹		2		NA	4
rs28954372^1,2	C,F,	--	127262705(+)	`TTACAC/TCCCCT`	1	--	us2k¹		2		NS	94
rs28954373^1,2	C,F,	--	127262744(+)	`TGCTGG/ATTTGA`	1	--	us2k¹		3		NS CSA	95
rs10258300^1,2	C,	--	127262798(+)	`cccggC/Tggccc`	1	--	us2k¹		1		NA	2
rs36219262^1,2	C,	--	127262883(+)	`ACCTAC/TGTTGA`	1	--	us2k¹		0	--	--	--	--
rs28954375^1,2	C,F,	--	127262953(+)	`GCATGA/GGCCAC`	1	--	us2k¹		4		NS NA	98
rs28954376^1,2	C,F	--	127262991(+)	`TTTTTC/T/TT CAAAC`	1	--	us2k¹ trp³		3		NS NA	96
rs113105436^1,2	C,	--	127262991(+)	`TTTTTT/CCAAAC`	1	--	us2k¹		2		CSA WA	120
rs791618^1,2	C,H,	--	127263016(+)	`aaaccA/Gttctt`	1	--	us2k¹		6		NS EA NA	422
rs28954378^1,2	C,F,	--	127263202(+)	`CACTTC/TCCAGG`	1	--	us2k¹		2		NS	94
rs111616216^1,2	C,	--	127263455(+)	`TCTGCG/ACAGTG`	1	--	us2k¹		1		WA	2
rs791619^1,2	C,H,	--	127263702(+)	`TACATC/GTGGGA`	1	--	us2k¹		7		MN NS EA NA WA	722
rs6976701^1,2	C,F,H,	--	127263737(+)	`CGTAGG/AAAATA`	1	--	us2k¹		15		NS EA NA WA	1864
rs28954080^1,2	C,F,	--	127263822(+)	`GAGAGC/TGTGCA`	1	--	us2k¹		6		NS NA WA	336
rs28954081^1,2	C,F,	--	127263846(+)	`CAGCCA/GGAGAC`	1	--	us2k¹		5		NS NA WA	216
rs10262600^1,2	C,F,H,	--	127263885(+)	`CTCCGC/TGTGCC`	1	--	us2k¹		6		NS EA	512
rs59357245^1,2	C,	--	127264035(+)	`CGAAGG/CCGCGC`	1	--	us2k¹		1		WA	2
rs791620^1,2	C,F,H,	--	127264267(+)	`CCTGGC/AGCGCC`	1	--	us2k¹		12		EA NS NA MN WA	894
rs34104384^1,2	C,	--	127264431(+)	`ATAAGA/TGGGGC`	1	--	us2k¹		6		MN WA	514
rs2278814^1,2	C,F,H,	--	127264671(+)	`GGAGCG/ATTGGA`	1	--	int¹		11		EA MN NS WA	2358
rs61520280^1,2	C,	--	127264833(+)	`TCCCAC/ACCCAG`	1	--	int¹		1		WA	2
rs113467677^1,2	C	--	127265130(+)	`ATACA-/ATGA ATGAG`	1	--	int¹		0	--	--	--	--
rs28954083^1,2	C,F,	--	127266069(+)	`CGTGGG/AAGCCA`	1	--	int¹		2		NS	90
rs112734810^1,2		--	127266173(+)	`TTTCCG/AGCAGT`	1	--	int¹		1		CSA	2
rs28954084^1,2	C,F,	--	127266275(+)	`CACAGT/ATGTCT`	1	--	int¹		5		NS NA WA	212
rs11978419^1,2	C,F,H,	--	127267362(+)	`aagtcG/Aggggt`	1	--	int¹		6		NS EA NA WA	530
rs113277332^1,2		--	127267413(+)	`GACAGG/AGCAAG`	1	--	int¹		1		CSA	1
rs10257175^1,2	C,F,H,	--	127267682(+)	`GAGCCG/AAGACT`	1	--	int¹		7		NS EA NA	575
rs77268534^1,2	F,	--	127267810(+)	`TGAGTA/GTAAGA`	1	--	int¹		1		WA	118
rs28954086^1,2	C,F,H,	--	127267980(+)	`GAGGCC/TAAATG`	1	--	int¹		9		NS NA WA	888
rs28954087^1,2	C,F,H,	--	127268028(+)	`AACTGG/AACTCT`	1	--	int¹		8		NS NA WA	788
rs28954088^1,2	C,F,H,	--	127268435(+)	`GGGAAC/TGCCTG`	1	--	int¹		9		NS NA WA	964
rs111305916^1,2	C,	--	127269041(+)	`GACCAG/ACCTGG`	1	--	int¹		1		NA	2
rs113837181^1,2	C,	--	127269044(+)	`CAGCCC/TGGCCA`	1	--	int¹		0	--	--	--	--
rs28756049^1,2	C,	--	127269270(+)	`AAAATA/TAAAAA`	1	--	int¹		3		NA NS	94
rs28954089^1,2	C,F,H,	--	127269436(+)	`GAGGTG/AGAGGG`	1	--	int¹		6		NS NA WA	718
rs1031340^1,2	C,F,	--	127269450(+)	`GGTGCG/AGGCCC`	1	--	int¹		3		WA	122
rs28954090^1,2	C,F,	--	127269660(+)	`GTCTTG/CCTGTG`	1	--	int¹		6		NS NA WA	214
rs71973524^1,2	C,	--	127269811(+)	`TTTTT-/ATTTTT`	1	--	int¹		0	--	--	--	--
rs113218407^1,2	C,	--	127269811(+)	`TTTTTA/TTTTTT`	1	--	int¹		0	--	--	--	--
rs28954092^1,2	C,F,H,	--	127270416(+)	`CAGCGG/AGCCCC`	1	--	int¹		6		NS NA	598
rs28954093^1,2	C,F,H,	--	127270442(+)	`CAGCCC/TTTTGT`	1	--	int¹		7		NS NA WA	540
rs28954094^1,2	C,F,H,	--	127270578(+)	`GTTTCC/AATCTC`	1	--	int¹		9		NS NA WA	1006
rs28954095^1,2	C,F,H,	--	127270783(+)	`TCCTCC/TACCTT`	1	--	int¹ trp³		14		NS NA WA CSA	1286
rs71578254^1,2	C,F,	--	127272041(+)	`GTGGGC/TGATCA`	1	--	int¹		3		NA	124
rs10277407^1,2	C,F,H,	--	127272148(+)	`attgtG/Agtttt`	1	--	int¹		8		NS EA NA WA	422
rs28954096^1,2	C,F,H,	--	127272566(+)	`TCCTGG/ATTCAA`	1	--	int¹		10		NS NA WA	1102
rs28954379^1,2	C,F,H,	--	127272714(+)	`CAGAAC/TTTAGT`	1	--	int¹		14		NS NA WA	1684
rs7791621^1,2	C,F,A,H,	--	127272817(+)	`tggggA/Cagaac`	1	--	int¹		12		NS EA NA WA	1400
rs73226681^1,2	C,	--	127272836(+)	`AGATAT/CTGGGA`	1	--	int¹		2		NA	122
rs73721326^1,2	C,	--	127273119(+)	`TATTAT/ACAGTG`	1	--	int¹		2		WA	120
rs7796202^1,2	C,F,H,	--	127273337(+)	`CACCCG/ACCCAT`	1	--	int¹		17		NS EA NA WA CSA	1746
rs28954097^1,2	C,F,H,	--	127273447(+)	`GGAAGT/CTTTAC`	1	--	int¹		7		NS NA WA	788
rs28954098^1,2	C,F,H,	--	127273734(+)	`GTTGAC/ATCCTA`	1	--	int¹		10		NS NA WA	1002
rs28954099^1,2	C,F,H,	--	127273899(+)	`TATTAC/TCTGTC`	1	--	int¹		8		NS NA	714
rs28954100^1,2	C,F,H,	--	127273900(+)	`ATTACC/TTGTCT`	1	--	int¹		9		NS NA WA	1000
rs28954101^1,2	C,F,H,	--	127273943(+)	`AGCGGA/GGATTA`	1	--	int¹		13		NS NA WA	1620
rs57191509^1,2	C,F,	--	127273978(+)	`TCATCC/TTAATA`	1	--	int¹		1		WA	118
rs28954102^1,2	C,F,H,	--	127274178(+)	`CAAGCG/ATTCTG`	1	--	int¹		9		NS NA CSA WA	908
rs28954103^1,2	C	--	127274215(+)	`CACCAT/CGTCTT`	1	--	int¹		4		NS NA	96
rs77448332^1,2		--	127274343(+)	`TAGTAG/TCTTGT`	1	--	int¹		0	--	--	--	--
rs28954104^1,2	C,F,H,	--	127274472(+)	`ATCCTC/TGGTGC`	1	--	int¹		10		NS NA WA	996
rs28954105^1,2	C,F,H,	--	127274737(+)	`GCCTAG/TAGATA`	1	--	int¹		10		NS NA WA	1094
rs77281811^1,2		--	127274858(+)	`TCCCTC/TGAGCA`	1	--	int¹		1		NA	120
rs28954106^1,2	C,F,	--	127275039(+)	`TGAGGG/CGATGG`	1	--	int¹		4		NS NA WA	86
rs28954107^1,2	C,F,H,	--	127275141(+)	`TTGCAA/G/TTGTGT`	1	--	int¹		7		NS NA	588
rs41474844^1,2	C,	--	127275156(+)	`CCTTCT/CGTTTT`	1	--	int¹		1		NA	48
rs142904532^1,2	C,F	--	127275207(+)	`GGAACC/GCTGTG`	2	T	syn¹		1		NA	4552
rs76529182^1,2	C	--	127275230(-)	`AGGGCA/CAAAGC`	2	W L	mis¹		0	--	--	--	--
rs148407750^1,2	C,F,	--	127275245(+)	`TTTCTA/GTGTCC`	2	Y C	mis¹		2		NA EU	5875
rs13306517^1,2	C,F,H,	--	127275267(+)	`ATCCAA/GAAAGT`	2	Q	syn¹		7		NS EA NA EU	6357
rs111650508^1,2	F	--	127275299(+)	`CATCAG/AGACAA`	2	/K /R	mis¹		1		CSA	4
rs13306518^1,2	H	--	127275384(+)	`CAGCAC/TTGGCT`	1	--	int¹		4		NS EA	420
rs113200967^1,2	C,	--	127275666(+)	`TGGGAC/GGCCAA`	1	--	int¹		0	--	--	--	--
rs112070222^1,2	C,	--	127275868(+)	`CCACCG/ATGCTC`	1	--	int¹		1		NA	2
rs77515392^1,2	F,	--	127276360(+)	`CTCTAT/GCCCAT`	1	--	int¹		1		EA	120
rs28954108^1,2	C,F,	--	127276378(+)	`TGTGCT/GTGTCA`	1	--	int¹		5		NS NA WA	216
rs11973652^1,2	C,F,H,	--	127276962(+)	`CTGCAC/TGTGAT`	1	--	int¹		7		NS EA NA	577
rs28954109^1,2	C,F,	--	127276968(+)	`GTGATA/GGATCC`	1	--	int¹		5		NS NA WA	216
rs17151913^1,2	C,F,H,	--	127277139(+)	`CTTGAT/ACTCTA`	1	--	int¹		13		NA NS EA WA CSA	780
rs3793162^1,2	C,F,H,	--	127277189(+)	`GACTCG/AGCTGG`	1	--	int¹		11		NS EA NA WA	750
rs6956510^1,2	C,F,	--	127277361(+)	`GGAGGG/AAAGGA`	1	--	int¹ trp³		9		NS NA WA CSA EA	342
rs113112089^1,2		--	127277369(+)	`GGATGG/TTGTGG`	1	--	int¹		1		CSA	2
rs28954110^1,2	C,F,	--	127277462(+)	`AGGGAG/CGGTGG`	1	--	int¹		5		NS NA WA	216
rs28954111^1,2	C,F,	--	127277471(+)	`GGAAGG/AAGGCA`	1	--	int¹		5		NS NA	218
rs17151914^1,2	C,F,H,	--	127277528(+)	`GAGAGC/TGATTC`	1	--	int¹		25		NA NS EA WA EU	3565
rs138908051^1,2	C,F	--	127277598(+)	`AAACAG/AAAAGT`	2	/Q	syn¹		2		NA EU	5873
rs140510728^1,2	C	--	127277637(+)	`CACCCC/GATCCT`	2	P	syn¹		1		NA	4552
rs17151919^1,2	C,F,H,	--	127277713(+)	`GAAACG/ATGATC`	2	/M /V	mis¹ ese³		27		NA NS EA WA	7022
rs28954113^1,2	C,F,	--	127277742(+)	`GAGAAA/C/TCTCCG`	3	K N	mis¹ syn¹ ese³		5		NS NA WA	4838
rs104894023^1,2	C	--	127277746(+)	`ACCTCC/TGGGAT`	2	R W	mis¹		0	--	--	--	--
rs1800564^1,2	C	--	127277761(+)	`TTCACG/ATGCTG`	2	/M /V	mis¹		3		NA	4556
rs200819049^1,2	C	--	127277925(+)	`CTCAGC/TCCTGG`	2	S	syn¹		1		EU	935
rs62481073^1,2	C,F,	--	127277970(+)	`GACTAC/TGTTAA`	1	--	ut3¹		2		NA EU	1139
rs28954114^1,2	C,F,H,	--	127277971(+)	`ACTACG/ATTAAG`	1	--	ut3¹ ese³		11		NS NA CSA WA	1234
rs28954115^1,2	C,F,H,	--	127278087(+)	`CAAAGG/ACATAA`	1	--	ut3¹ ese³		6		NS NA	498
rs113405088^1,2	C,	--	127278141(+)	`GGATCT/CTATTC`	1	--	ut3¹		1		CSA	1
rs28954116^1,2	C,F,	--	127278166(+)	`GTCCAC/GCCAGC`	1	--	ut3¹ ese³		5		NS NA WA	262
rs140383020^1,2	C,	--	127278179(+)	`AGAGTG/TGGCTG`	1	--	ut3¹		0	--	--	--	--
rs28954117^1,2	C,F,H,	--	127278224(+)	`ACAAGA/GGTTGT`	1	--	ut3¹		7		NS NA	656
rs191600447^1,2	C,	--	127278237(+)	`TGTCCC/TCTCTT`	1	--	ut3¹		0	--	--	--	--
rs28954118^1,2	C,F,	--	127278303(+)	`GGCAGA/G/TGGGGT`	2	--	ut3¹ ese³		5		NS NA	218
rs183801334^1,2	C,	--	127278310(+)	`GGGTAA/GGCAGA`	1	--	ut3¹		0	--	--	--	--
rs17151922^1,2	C,F,H,	--	127278337(+)	`AACAAG/TGTTCC`	1	--	ut3¹ ese³		20		NA NS EA WA	2054
rs111880866^1,2	C,	--	127278528(+)	`AGTTTC/ACAATC`	1	--	ut3¹		1		CSA	2
rs111365240^1,2	C,	--	127278622(+)	`TCTCCG/AGTTAG`	1	--	ut3¹		1		CSA	2
rs192559065^1,2	C,	--	127278694(+)	`TGTTGC/TCCTGA`	1	--	ut3¹		0	--	--	--	--
rs70940808^1,2	C,	--	127278718(+)	`GACCAG/CGTTAT`	1	--	ut3¹		1		NA	48
rs114834517^1,2	C,F,	--	127278722(+)	`AGGTTA/C/GTTTTA`	2	--	ut3¹		1		WA	118
rs41526944^1,2	C	--	127278922(+)	`TTCAGA/C/GGGGGT`	2	--	ut3¹		1		NA	48
rs138289049^1,2	C,	--	127278947(+)	`AGGCAA/CCCCCT`	1	--	ut3¹		0	--	--	--	--
rs151325384^1,2	C,	--	127278951(+)	`ACCCCC/GTGGAG`	1	--	ut3¹		0	--	--	--	--
rs3750034^1,2	C,H	--	127279061(+)	`TTGGGG/ACAGTG`	1	--	ut3¹ ese³		4		NS EA	420
rs13306516^1,2	H	--	127279085(+)	`TTCTCC/TGACTG`	1	--	ut3¹ ese³		4		NS EA	412
rs190525190^1,2	C,	--	127279143(+)	`ACTGCA/GATCTT`	1	--	ut3¹		0	--	--	--	--
rs6966536^1,2	C,F,H,	--	127279180(+)	`TCTGAA/GTGGTC`	1	--	ut3¹ ese³		5		NS EA WA	532
rs144195028^1,2	C,	--	127279197(+)	`TGATCA/GCACTC`	1	--	ut3¹		0	--	--	--	--
rs28959468^1,2	C,F,H,	--	127279312(+)	`GGGGGT/GTTTTA`	1	--	ut3¹ ese³		7		NS NA CSA WA	620
rs28959469^1,2	C,	--	127279465(+)	`TTTGGG/CGTCTG`	1	--	ut3¹		3		NS NA	96
rs184444762^1,2	C,	--	127279596(+)	`GTGCTA/GTAGGC`	1	--	ut3¹		0	--	--	--	--
rs188857005^1,2	C,	--	127279615(+)	`CTCACC/TCAATA`	1	--	ut3¹		0	--	--	--	--
rs28959470^1,2	C,F,	--	127279704(+)	`GGTATT/ATACCA`	1	--	ut3¹ ese³		5		NS NA WA	216
rs41528456^1,2	C,	--	127279901(+)	`AATAAG/AAAAAT`	1	--	ut3¹		1		NA	48
rs28959471^1,2	C,F,H,	--	127279952(+)	`TATAGC/ACCAGG`	1	--	ut3¹ ese³		9		NS NA	1014
rs41434248^1,2	C,F,	--	127279983(+)	`TACGTG/AAGCCA`	1	--	ut3¹		2		NA	168
rs17617757^1,2	C,	--	127279990(+)	`GCCAGG/ATAATG`	1	--	ut3¹ ese³		3		NA	142
rs187235717^1,2	C,	--	127280047(+)	`TTCGAG/TGTAGA`	1	--	ut3¹		0	--	--	--	--
rs28959472^1,2	C,F,H,	--	127280161(+)	`ACAGCG/AAGAGG`	1	--	ut3¹ ese³		7		NS EA NA	488
rs28959473^1,2	C,	--	127280178(+)	`AAGAAG/CAGACA`	1	--	ut3¹ trp³		4		NS NA	94
rs28959474^1,2	C,F,H,	--	127280347(+)	`CTGAGG/ATGTCT`	1	--	ut3¹ ese³		10		NS NA WA	1102
rs200431904^1,2	C	--	127280440(+)	`TGTAAA/C/TTTAAA`	2	--	ut3¹		0	--	--	--	--
rs28959475^1,2	C,F,	--	127280532(+)	`AAGGTC/AACTAG`	1	--	ut3¹ ese³		4		NS CSA WA	210
rs28959476^1,2	C,F,	--	127280684(+)	`AGTACA/TGTGAG`	1	--	ut3¹ ese³		2		NS	88
rs28959478^1,2	C,F,	--	127281110(+)	`GGGATC/ACACTT`	1	--	ds500¹		5		NS NA WA	212
rs112067975^1,2		--	127281164(+)	`GCATCC/TACTGG`	1	--	ds500¹		1		CSA	2
rs188789653^1,2		--	127879334(+)	`GAATGC/TCTATC`	1	--	us2k¹		0	--	--	--	--
rs4728096^1,2	C,F,H,	--	127879348(+)	`CGCAAT/CGGAGA`	1	--	us2k¹		8		EA NS NA WA	620
rs12536535^1,2	C,F,A,H,	--	127879368(+)	`AGATAC/TGCCCT`	1	--	us2k¹		4		NA	8
rs181271386^1,2		--	127879459(+)	`CTCTCA/GAACAC`	1	--	us2k¹		0	--	--	--	--
rs28954370^1,2	C,	--	127879501(+)	`CAATAC/TGTGCA`	1	--	us2k¹		2		NS	94
rs142998315^1,2		--	127879563(+)	`TGTGAC/TCTACT`	1	--	us2k¹		0	--	--	--	--
rs191070405^1,2		--	127879630(+)	`AGGCTC/TAGGTG`	1	--	us2k¹		0	--	--	--	--
rs191912842^1,2		--	127879920(+)	`AAACCC/TGGCAG`	1	--	us2k¹		0	--	--	--	--
rs13228377^1,2	C,F,	--	127879944(+)	`TCACCA/GACGTC`	1	--	us2k¹		9		NS NA CSA WA EA	457
rs28954377^1,2	C,	--	127879989(+)	`TTTTG-/TTTTTT`	1	--	us2k¹		2		NS	94
rs182979954^1,2		--	127879998(+)	`GTTTTG/TTTTAT`	1	--	us2k¹		0	--	--	--	--
rs139576122^1,2		--	127880416(+)	`ACCTCC/GCTGGA`	1	--	us2k¹		0	--	--	--	--
rs149859930^1,2		--	127880454(+)	`AGGGT-/AAAA CAAAACAAAAC`	1	--	us2k¹		0	--	--	--	--
rs149734198^1,2		--	127880514(+)	`ACAAAC/TGATAC`	1	--	us2k¹		0	--	--	--	--
rs138470026^1,2		--	127880640(+)	`CCCAC-/AAGTAT`	1	--	us2k¹		0	--	--	--	--
rs145625824^1,2		--	127880839(+)	`GCCGCA/TCCCTC`	1	--	us2k¹		0	--	--	--	--
rs114840134^1,2		--	127880855(+)	`CTGGGC/TTTCCC`	1	--	us2k¹		0	--	--	--	--
rs139459016^1,2		--	127880951(+)	`CCAGCC/GCGCTC`	1	--	us2k¹		0	--	--	--	--
rs182552738^1,2		--	127880998(+)	`GCCCCG/TCGCGG`	1	--	us2k¹		0	--	--	--	--
rs187788556^1,2		--	127881002(+)	`CGCGCC/GGCTCG`	1	--	us2k¹		0	--	--	--	--
rs192763413^1,2		--	127881172(+)	`CCCGCA/GAGGTG`	1	--	us2k¹		0	--	--	--	--
rs184172933^1,2		--	127881210(+)	`GCCCGG/TCACGT`	1	--	us2k¹		0	--	--	--	--
rs2167270^1,2	C,F,O,H,	--	127881349(+)	`CGCCAG/ACGGTT`	1	--	ut5¹ ese³		31		NA NS EA MN WA CSA	2966
rs143983443^1,2		--	127881666(+)	`TGCATC/TGGAAA`	1	--	int¹		0	--	--	--	--
rs192460908^1,2		--	127881790(+)	`CTTGCC/TCTGCG`	1	--	int¹		0	--	--	--	--
rs2278815^1,2	C,F,H,	--	127881851(+)	`GAGGGA/GCTGTG`	1	--	int¹		15		EA NS NA CSA WA	2180
rs184715984^1,2		--	127881998(+)	`TTGCAA/GTGCAT`	1	--	int¹		0	--	--	--	--
rs148577397^1,2	C,	--	127882005(+)	`CATAC-/AATG AATGA`	1	--	int¹		0	--	--	--	--
rs189036735^1,2		--	127882057(+)	`GCCAGA/GACTGC`	1	--	int¹		0	--	--	--	--
rs4731426^1,2	C,F,A,H,	--	127882070(+)	`AATACC/GCGCTG`	1	--	int¹		31		NA NS EA CSA WA	3070
rs191998411^1,2		--	127882203(+)	`TGACTC/TCTTAA`	1	--	int¹		0	--	--	--	--
rs184900134^1,2		--	127882309(+)	`GGGGAA/GGTGGG`	1	--	int¹		0	--	--	--	--
rs189428321^1,2		--	127882364(+)	`TCTTCC/TTTTGC`	1	--	int¹		0	--	--	--	--
rs140880909^1,2		--	127882476(+)	`TATTAA/GGATTG`	1	--	int¹		0	--	--	--	--
rs181029455^1,2		--	127882883(+)	`GTGGAG/TGTGGC`	1	--	int¹		0	--	--	--	--
rs143088141^1,2		--	127882894(+)	`CGCCAC/TGGAAC`	1	--	int¹		0	--	--	--	--
rs147103220^1,2		--	127882912(+)	`TCCCA-/CCCCCC`	1	--	int¹		0	--	--	--	--
rs189498205^1,2		--	127882987(+)	`TCCTTG/TTGTCT`	1	--	int¹		0	--	--	--	--
rs2122627^1,2	C,F,H,	--	127883323(+)	`GGAATC/TTATAA`	1	--	int¹		26		NS EA NA WA CSA	2271
rs116086890^1,2		--	127883348(+)	`AACATC/TTCACT`	1	--	int¹		0	--	--	--	--
rs141046416^1,2		--	127883376(+)	`AGTCTC/TCATCT`	1	--	int¹		0	--	--	--	--
rs150257621^1,2		--	127883420(+)	`GGCTGG/TGGGGT`	1	--	int¹		0	--	--	--	--
rs139341325^1,2		--	127883526(+)	`AGGCTC/GATGAA`	1	--	int¹		0	--	--	--	--
rs143352223^1,2		--	127883540(+)	`GGCCAC/TGGGCG`	1	--	int¹		0	--	--	--	--
rs181836716^1,2		--	127883545(+)	`CGGGCA/GGGAGT`	1	--	int¹		0	--	--	--	--
rs147031287^1,2		--	127883573(+)	`AAGATA/GGAGCA`	1	--	int¹		0	--	--	--	--
rs4236625^1,2	C,F,A,H,	--	127883695(+)	`TTTTCA/TGTCTT`	1	--	int¹		28		NS EA NA WA CSA	2779
rs186091007^1,2		--	127883811(+)	`AGCCAA/GTGCAG`	1	--	int¹		0	--	--	--	--
rs190504107^1,2		--	127883855(+)	`AACAGA/GTATTT`	1	--	int¹		0	--	--	--	--
rs182792491^1,2		--	127883875(+)	`CTGCCA/GTGTTC`	1	--	int¹		0	--	--	--	--
rs33910507^1,2	C	--	127884140(+)	`AAAAA-/AGTAAC`	1	--	int¹		0	--	--	--	--
rs66718027^1,2	C	--	127884140(-)	`ACTTTT/-TTTTT`	1	--	int¹		1		NA	2
rs56394457^1,2	C,	--	127884153(+)	`AAAAAA/G/TTAACT`	1	--	int¹		2		WA EA	122
rs186624903^1,2		--	127884230(+)	`GCCCGA/GGAAGT`	1	--	int¹		0	--	--	--	--
rs67458695^1,2	C,	--	127884300(+)	`CACAC-/ACAC ACACA`	1	--	int¹		0	--	--	--	--
rs144714062^1,2		--	127884300(+)	`CCCTG-/ACACACAC ACACACACACACACA`	1	--	int¹		0	--	--	--	--
rs147331670^1,2	C,	--	127884300(+)	`CCCTG-/ACACAC ACACA`	1	--	int¹		0	--	--	--	--
rs4731427^1,2	C,F,A,H,	--	127884389(+)	`CAGATT/CTTTCT`	1	--	int¹		28		NS EA NA WA CSA	2569
rs191129878^1,2		--	127884486(+)	`TTGCAA/GATAAG`	1	--	int¹		0	--	--	--	--
rs182970851^1,2		--	127884505(+)	`ACTCAC/TGCTGG`	1	--	int¹		0	--	--	--	--
rs187586889^1,2		--	127884587(+)	`CCCACA/GGTAAG`	1	--	int¹		0	--	--	--	--
rs192659102^1,2		--	127884790(+)	`CAGGCA/GGTGAC`	1	--	int¹		0	--	--	--	--
rs114915388^1,2	F,	--	127884823(+)	`GTGGGC/TTCTGG`	1	--	int¹		1		WA	118
rs150818455^1,2	C,	--	127885094(+)	`GTGTA-/TGTGTGT`	1	--	int¹		0	--	--	--	--
rs183408270^1,2		--	127885181(+)	`AAGCCC/TGCAAA`	1	--	int¹		0	--	--	--	--
rs141256175^1,2		--	127885182(+)	`AGCCCA/GCAAAA`	1	--	int¹		0	--	--	--	--
rs187705106^1,2		--	127885375(+)	`ATCCCC/TGGAGT`	1	--	int¹		0	--	--	--	--
rs139392472^1,2		--	127885376(+)	`TCCCCA/GGAGTC`	1	--	int¹		0	--	--	--	--
rs192215645^1,2		--	127885623(+)	`AGGGGA/GTCCCA`	1	--	int¹		0	--	--	--	--
rs185102245^1,2		--	127885716(+)	`TTTAAC/TTCACA`	1	--	int¹		0	--	--	--	--
rs144164446^1,2		--	127885803(+)	`GGAGGC/TCCTCC`	1	--	int¹		0	--	--	--	--
rs189957581^1,2		--	127885844(+)	`AGGCTC/TGGTGG`	1	--	int¹		0	--	--	--	--
rs192696222^1,2		--	127885888(+)	`GAGGCA/GGGTGG`	1	--	int¹		0	--	--	--	--
rs180675592^1,2		--	127885979(+)	`GTGCGG/TTGGTG`	1	--	int¹		0	--	--	--	--
rs11980266^1,2	C,A,H,	--	127886008(+)	`tacccA/Gggagg`	1	--	int¹		0	--	--	--	--
rs140782690^1,2		--	127886073(+)	`GAGCCA/GAGGTC`	1	--	int¹		0	--	--	--	--
rs186347613^1,2		--	127886110(+)	`CAGAGC/TAAGAC`	1	--	int¹		0	--	--	--	--
rs145511447^1,2		--	127886213(+)	`GTCCCC/TAGGAT`	1	--	int¹		0	--	--	--	--
rs148861526^1,2		--	127886236(+)	`TCCATC/TTGCCT`	1	--	int¹		0	--	--	--	--
rs189202459^1,2		--	127886380(+)	`TGAGGA/TTAAGT`	1	--	int¹		0	--	--	--	--
rs182126597^1,2		--	127886505(+)	`TTATCC/TTTTTT`	1	--	int¹		0	--	--	--	--
rs186676333^1,2		--	127886550(+)	`TCACAC/TAGGCT`	1	--	int¹		0	--	--	--	--
rs28954091^1,2	C,F,	--	127886605(+)	`GGGCTC/TAGGCA`	1	--	int¹		9		NS NA CSA WA EA	458
rs200332485^1,2		--	127886685(+)	`TTTTA-/TTTTTA`	1	--	int¹		0	--	--	--	--
rs201956597^1,2		--	127886689(+)	`ATTTT-/TATTTTT`	1	--	int¹		0	--	--	--	--
rs2060713^1,2	C,F,H,	--	127887029(+)	`GAGCAC/TACAGC`	1	--	int¹		17		NS EA NA WA CSA	874
rs114964194^1,2		--	127887051(+)	`CCACCA/GTCTTC`	1	--	int¹		1		WA	118
rs12706831^1,2	C,F,	--	127887068(+)	`ACCCCG/TCTCCT`	1	--	int¹ trp³		9		NS NA EA	338
rs191625064^1,2		--	127887071(+)	`CCTCTC/TCTCTC`	1	--	int¹		0	--	--	--	--
rs142396524^1,2		--	127887082(+)	`CAGGAG/TCTGCT`	1	--	int¹		0	--	--	--	--
rs12706832^1,2	C,F,H,	--	127887139(+)	`AGCTCA/GTCTTT`	1	--	int¹		28		NA NS EA CSA WA	2914
rs147938367^1,2		--	127887207(+)	`GAGAGG/TTTTTG`	1	--	int¹		0	--	--	--	--
rs182961864^1,2		--	127887482(+)	`GCCAGA/GCTGAA`	1	--	int¹		0	--	--	--	--
rs147117504^1,2		--	127887666(+)	`CCACCG/TTCACA`	1	--	int¹		0	--	--	--	--
rs185545324^1,2		--	127888020(+)	`AGGCAC/TTTCTT`	1	--	int¹		0	--	--	--	--
rs189864892^1,2		--	127888059(+)	`CAGTGA/GCTCAG`	1	--	int¹		0	--	--	--	--
rs138251528^1,2		--	127888074(+)	`AATGCA/GGTGGC`	1	--	int¹		0	--	--	--	--
rs140936524^1,2		--	127888077(+)	`GCGGTA/GGCTCA`	1	--	int¹		0	--	--	--	--
rs150204746^1,2		--	127888100(+)	`CAACAC/TTTTGG`	1	--	int¹		0	--	--	--	--
rs10243710^1,2	C,H,	--	127888250(+)	`AGGCCG/AAGGCA`	1	--	int¹		6		NA WA CSA	11
rs114915709^1,2	F,	--	127888530(+)	`TGCCCG/ATAATT`	1	--	int¹		1		WA	118
rs10244329^1,2	C,F,A,H,	--	127888689(+)	`TTGCAA/TTGAAG`	1	--	int¹		28		NS EA NA WA CSA	2840
rs182169554^1,2		--	127888728(+)	`CTTAAA/GGGCAC`	1	--	int¹		0	--	--	--	--
rs149386046^1,2		--	127888808(+)	`ACACTA/TCCGAG`	1	--	int¹		0	--	--	--	--
rs188026445^1,2		--	127888879(+)	`CTGTGC/TTTCCA`	1	--	int¹		0	--	--	--	--
rs114122063^1,2	F,	--	127888889(+)	`ATATCT/CTTTTC`	1	--	int¹		1		WA	118
rs146236504^1,2		--	127888912(+)	`GGCCCA/CCAGTG`	1	--	int¹		0	--	--	--	--
rs117049059^1,2		--	127888921(+)	`TGGGCG/AATCAA`	1	--	int¹		1		NA	120
rs192448737^1,2		--	127889030(+)	`GTGGTC/TTTTAA`	1	--	int¹		0	--	--	--	--
rs183846952^1,2		--	127889376(+)	`TCCATC/TAACCT`	1	--	int¹		0	--	--	--	--
rs188329717^1,2		--	127889446(+)	`CCTGGA/TTCAAG`	1	--	int¹		0	--	--	--	--
rs193025377^1,2		--	127889464(+)	`TAGAAC/TGTTGG`	1	--	int¹		0	--	--	--	--
rs138049608^1,2		--	127889537(+)	`CACACA/GACAGG`	1	--	int¹		0	--	--	--	--
rs142623551^1,2		--	127889563(+)	`ACAGGA/GCACTT`	1	--	int¹		0	--	--	--	--
rs184775528^1,2		--	127889564(+)	`CAGGAC/TACTTC`	1	--	int¹		0	--	--	--	--
rs186896865^1,2		--	127889616(+)	`CCTAGC/TTGGGA`	1	--	int¹		0	--	--	--	--
rs191349329^1,2		--	127889931(+)	`TCAGCA/GGCAGC`	1	--	int¹		0	--	--	--	--
rs115650748^1,2	C,F,	--	127890002(+)	`ATCAGT/CGGTGA`	1	--	int¹		1		WA	118
rs183582933^1,2		--	127890042(+)	`CTTAGA/GTATTA`	1	--	int¹		0	--	--	--	--
rs11763517^1,2	C,F,A,H,	--	127890062(+)	`CATTAT/CTTGAG`	1	--	int¹		29		NA NS EA WA	3070
rs148703404^1,2		--	127890077(+)	`ACTATC/GACCAC`	1	--	int¹		0	--	--	--	--
rs7795794^1,2	C,F,A,H,	--	127890151(+)	`TTGCCG/AGGAGA`	1	--	int¹		18		NS EA NA WA CSA	880
rs142057007^1,2		--	127890199(+)	`GCAGAC/GCCTAA`	1	--	int¹		0	--	--	--	--
rs139082407^1,2		--	127890336(+)	`CTTTTC/TTAAGA`	1	--	int¹		0	--	--	--	--
rs149911234^1,2		--	127890378(+)	`ACATAC/GTACTT`	1	--	int¹		0	--	--	--	--
rs147921807^1,2		--	127890419(+)	`TACCAC/TAGCTT`	1	--	int¹		0	--	--	--	--
rs1349398^1,2	C,H,	--	127890648(+)	`TCTGTA/GAAATT`	1	--	int¹		16		NS EA NA WA CSA	780
rs141758001^1,2		--	127890660(+)	`AGATTA/TAAAAA`	1	--	int¹		0	--	--	--	--
rs145609186^1,2		--	127890759(+)	`CATCTA/GTGGAC`	1	--	int¹		0	--	--	--	--
rs74423439^1,2	F,	--	127890813(+)	`AACACG/AAAAAG`	1	--	int¹		1		EA	120
rs147743935^1,2		--	127890820(+)	`AAAGCA/GGAGAT`	1	--	int¹		0	--	--	--	--
rs149228774^1,2		--	127890966(+)	`CTCATA/GTATCT`	1	--	int¹		0	--	--	--	--
rs11760956^1,2	C,F,H,	--	127891087(+)	`CTCCCG/ACCACC`	1	--	int¹		21		NS EA NA WA	2434
rs143229153^1,2		--	127891207(+)	`CCCTGG/TGCCTT`	1	--	int¹		0	--	--	--	--
rs189445518^1,2		--	127891367(+)	`ACTGCG/TTCTGA`	1	--	int¹		0	--	--	--	--
rs10954173^1,2	C,F,A,H,	--	127891440(+)	`AGGACG/ATAAGG`	1	--	int¹		28		NS EA NA WA	2886
rs140483549^1,2		--	127891554(+)	`AGCACA/GTTTCA`	1	--	int¹		0	--	--	--	--
rs182123400^1,2		--	127891627(+)	`GATATA/GTTACA`	1	--	int¹		0	--	--	--	--
rs145707401^1,2		--	127891645(+)	`AGGTGC/GAGTAT`	1	--	int¹		0	--	--	--	--
rs137975623^1,2		--	127891660(+)	`TGGTTA/TTGTGA`	1	--	int¹		0	--	--	--	--
rs142560926^1,2		--	127891722(+)	`AAAGTA/CTGTTA`	1	--	int¹		0	--	--	--	--
rs185451543^1,2		--	127891760(+)	`TACATC/TATCCC`	1	--	int¹		0	--	--	--	--
rs190027670^1,2		--	127891812(+)	`GGTCTA/GCAGGA`	1	--	int¹		0	--	--	--	--
rs138636985^1,2		--	127891959(+)	`ATCCCC/TGTCTG`	1	--	int¹		0	--	--	--	--
rs147166686^1,2	C,	--	127892231(+)	`TATGCA/GGGGAC`	1	--	int¹		0	--	--	--	--
rs140447473^1,2	C,	--	127892249(+)	`AACTGA/CAGCCA`	1	--	int¹		0	--	--	--	--
rs145542727^1,2		--	127892326(+)	`GAATGC/GCAGGC`	1	--	int¹		0	--	--	--	--
rs181616136^1,2		--	127892409(+)	`GCCTGC/GTGAGA`	1	--	int¹		0	--	--	--	--
rs145999522^1,2	C,	--	127892785(+)	`TCTCA-/AAAT AAATA`	1	--	int¹		0	--	--	--	--
rs2071045^1,2	C,F,H,	--	127892980(+)	`AATCAT/CAGGAT`	1	--	int¹		24		EA NS NA	4226
rs190178572^1,2		--	127893001(+)	`CCTCAA/CGTGCT`	1	--	int¹		0	--	--	--	--
rs139962194^1,2		--	127893043(+)	`CTCAGC/TGATTA`	1	--	int¹		0	--	--	--	--
rs114650087^1,2	C,	--	127893114(+)	`TTCTGC/TGCTCG`	1	--	int¹		0	--	--	--	--
rs145691400^1,2		--	127893116(+)	`CTGCGC/TTCGCC`	1	--	int¹		0	--	--	--	--
rs180968923^1,2		--	127893161(+)	`CCTACA/GACCAG`	1	--	int¹		0	--	--	--	--
rs10264361^1,2	C,F,H,	--	127893203(+)	`GCAGGT/AACAAG`	1	--	int¹		17		NS EA NA WA CSA	756
rs118143276^1,2		--	127893218(+)	`CCAGAA/TGCATC`	1	--	int¹		1		NA	120
rs185297141^1,2		--	127893281(+)	`AGTTCC/TAGCTG`	1	--	int¹		0	--	--	--	--
rs145663745^1,2		--	127893290(+)	`TGATCC/TCTGGC`	1	--	int¹		0	--	--	--	--
rs146574563^1,2		--	127893585(+)	`TTGTTA/GTGAGG`	1	--	int¹		0	--	--	--	--
rs192469663^1,2		--	127893687(+)	`TGGTAA/GTCTTG`	1	--	int¹		0	--	--	--	--
rs116857910^1,2	F,	--	127893797(+)	`ATAATA/TAAAAA`	1	--	int¹		1		EA	120
rs7788818^1,2	C,F,A,H,	--	127893884(+)	`TACACG/AATATC`	1	--	int¹		29		NS EA NA WA CSA	2361
rs183910300^1,2		--	127893994(+)	`GGGGGA/GCCTCA`	1	--	int¹		0	--	--	--	--
rs144755411^1,2		--	127894067(+)	`GGACTC/TGGCTG`	1	--	int¹		0	--	--	--	--
rs188857788^1,2		--	127894168(+)	`TGAAAA/CCATGG`	1	--	int¹		0	--	--	--	--
rs141314857^1,2		--	127894253(+)	`GTGTGA/GGAAAA`	1	--	int¹		0	--	--	--	--
rs3828942^1,2	C,F,H,	--	127894305(+)	`TGGGTA/GCAGGA`	1	--	int¹		17		EA NS NA CSA WA	2427
rs28954112^1,2	C	--	127894383(+)	`CCCACG/AGGGAA`	1	--	int¹		4		NS NA EU	689
rs201114917^1,2		--	127894655(+)	`TCTCTA/GAGAGC`	2	K E	mis¹		0	--	--	--	--
rs191666811^1,2	C,	--	127894796(+)	`AGCTGA/GACCTC`	2	N D	mis¹		0	--	--	--	--
rs148774522^1,2		--	127895611(+)	`AAAAAG/TATTTG`	1	--	ut3¹		0	--	--	--	--
rs185570072^1,2		--	127895718(+)	`TGTGTA/GGTGGG`	1	--	ut3¹		0	--	--	--	--
rs139781325^1,2		--	127896003(+)	`TGACGA/GTCCCA`	1	--	ut3¹		0	--	--	--	--
rs146556007^1,2		--	127896097(+)	`ACATGA/GCAGTG`	1	--	ut3¹		0	--	--	--	--
rs76601079^1,2	C,F,	--	127896244(+)	`CCTGAC/AAAGCA`	1	--	ut3¹		2		NA EA	168
rs181791569^1,2		--	127896257(+)	`GCTAGA/GCGAGT`	1	--	ut3¹		0	--	--	--	--
rs10954174^1,2	C,F,A,H,	--	127896536(+)	`CTTGCG/ATTCCC`	1	--	ut3¹ ese³		32		NS EA NA WA CSA	2587
rs181229468^1,2		--	127896570(+)	`TGTGCA/CAAGGT`	1	--	ut3¹		0	--	--	--	--
rs200090823^1,2		--	127896650(+)	`GCTGA-/GGGGGG`	1	--	ut3¹		0	--	--	--	--
rs185532950^1,2		--	127896651(+)	`GCTGAA/GGGGGG`	1	--	ut3¹		0	--	--	--	--
rs1

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LEP Gene

leptin

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for LEP gene

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for LEP gene

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for LEP gene

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for LEP gene

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for LEP gene

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for LEP gene

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for LEP gene

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for LEP gene

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for LEP gene

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for LEP gene

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LEP Gene

leptin

Aliasesfor LEP gene

Summariesfor LEP gene

Genomic Viewsfor LEP gene

Proteinsfor LEP gene

Protein Domains /Familiesfor LEP gene

Functionfor LEP gene

Pathways & Interactionsfor LEP gene

Drugs & Compoundsfor LEP gene

Transcriptsfor LEP gene

Expression for LEP gene

Orthologsfor LEP gene

Paralogsfor LEP gene

Genomic Variantsfor LEP gene

Aliases
for LEP gene

Summaries
for LEP gene

Genomic Views
for LEP gene

Proteins
for LEP gene

Protein Domains /
Families
for LEP gene

Function
for LEP gene

Pathways & Interactions
for LEP gene

Drugs & Compounds
for LEP gene

Transcripts
for LEP gene

Expression
for LEP gene

Orthologs
for LEP gene

Paralogs
for LEP gene

Genomic Variants
for LEP gene