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LEP Gene

protein-coding   GIFtS: 66
GCID: GC07P127881


(Previous names: leptin (murine obesity homolog), leptin (obesity homolog,...)
(Previous symbols: OBS, OB)
  See LEP-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

leptin1 2     Obese Protein2 3
OB1 2 3 5     Obesity Factor2 3
OBS1 2 3     LEPD2 5
Leptin (Murine Obesity Homolog)1 2     Obese, Mouse, Homolog Of2
Leptin (Obesity Homolog, Mouse)1 2     

External Ids:    HGNC: 65531   Entrez Gene: 39522   Ensembl: ENSG000001746977   OMIM: 1641605   UniProtKB: P411593   

Export aliases for LEP gene to outside databases

Previous GC identifiers: GC07P126358 GC07P127421 GC07P127435 GC07P127475 GC07P127668 GC07P122242

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LEP Gene:
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation
of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway
that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This
protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory
responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions
cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes
mellitus development. (provided by RefSeq, Jul 2008)

GeneCards Summary for LEP Gene:
LEP (leptin) is a protein-coding gene. Diseases associated with LEP include congenital leptin deficiency, and diencephalic syndrome. GO annotations related to this gene include growth factor activity and peptide hormone receptor binding.

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159
Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An
increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate
energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

summary for LEP Gene:
Leptin was initially thought to have a role in energy homeostasis and obesity. More recently, it has also
been implicated in the regulation of reproduction, glucose homeostasis, bone formation, wound healing and
the immune system. Leptin acts via leptin receptors, which are transmembrane catalytic receptors found on
NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one
human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at
physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so
through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates
transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid
expression. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese
individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier)
expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are
of great interest in the development of pharmacological treatments for obesity.

Gene Wiki entry for LEP (Leptin) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LEP gene promoter:
         GR   C/EBPbeta   AP-1   ATF-2   GR-beta   AP-2gamma   AREB6   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): LEP promoter sequence
   Search Chromatin IP Primers for LEP

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LEP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q31

LEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LEP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P127881:  view genomic region     (about GC identifiers)

127,881,331 bp from pter      End:
127,897,682 bp from pter
16,352 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 127,264,455-127,280,803     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159 (See protein sequence)
Recommended Name: Leptin precursor  
Size: 167 amino acids; 18641 Da
Subunit: Interacts with SIGLEC6
1 PDB 3D structure from and Proteopedia for LEP:
1AX8 (3D)    
Secondary accessions: O15158 Q56A88

Explore the universe of human proteins at neXtProt for LEP: NX_P41159

Explore proteomics data for LEP at MOPED

See LEP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000221.1  
ENSEMBL proteins: 
Reactome Protein details: P41159

LEP Human Recombinant Protein Products:

EMD Millipore Purified and/or Recombinant LEP Protein
R&D Systems Recombinant & Natural Proteins for LEP (Leptin/OB)
Enzo Life Sciences proteins for LEP
OriGene Purified Proteins for LEP
OriGene Protein Over-expression Lysate for LEP
OriGene MassSpec for LEP
OriGene Custom Protein Services for LEP
GenScript Purified and Recombinant Proteins for LEP
Novus Biologicals LEP Proteins
Novus Biologicals LEP Lysate
Sino Biological Recombinant Protein for LEP
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for LEP
Cloud-Clone Corp. Proteins for LEP

Search eBioscience for Proteins for LEP 

antibodies-online proteins for LEP (270 products) 

antibodies-online peptides for LEP

GeneTex Proteins for LEP: (see all 3
                    Leptin Recombinant Protein (Active) (GTX48405-PRO)

LEP Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of LEP
R&D Systems Antibodies for LEP (Leptin/OB)
OriGene Antibodies for LEP
OriGene Custom Antibody Services for LEP
Novus Biologicals LEP Antibodies
Abcam antibodies for LEP
Cloud-Clone Corp. Antibodies for LEP
ThermoFisher Antibody for LEP
antibodies-online antibodies for LEP (293 products) 

GeneTex Antibodies for LEP:  
                    LEP Antibodies

LEP Assay Products:

EMD Millipore Kits and Assays for the Analysis of LEP
OriGene Custom Assay Services for LEP
R&D Systems ELISAs for LEP (Leptin/OB)         (see all)
GenScript Custom Assay Services for LEP
Enzo Life Sciences assays for LEP
Cloud-Clone Corp. ELISAs for LEP
Cloud-Clone Corp. CLIAs for LEP
eBioscience ELISAs for LEP:  
                    Human Leptin Instant ELISA 128 tests
antibodies-online kits for LEP (95 products) 

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

3 InterPro protein domains:
 IPR009079 4_helix_cytokine-like_core
 IPR012351 4_helix_cytokine_core
 IPR000065 Leptin

Graphical View of Domain Structure for InterPro Entry P41159

ProtoNet protein and cluster: P41159

1 Blocks protein domain: IPB000065 Obesity factor (leptin) signature

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159
Similarity: Belongs to the leptin family

Find genes that share domains with LEP           About GenesLikeMe

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: LEP_HUMAN, P41159
Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An
increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate
energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

     Genatlas biochemistry entry for LEP:
leptin,adipocyte-specific secreted protein,18.6kDa,controlling the size of adipose depot by a profound effect of
appen appetite and energy expenditure,also involved in control of the hypothalamic-pituitary-gonadal (HPG)
axis,also putative angiogenic factor,homolog of the murine obese gene (ob)

During embryonic development, LEP as signaling molecule is secreted from the following cells:
            fully expand
Adipose: Subcutaneous White Adipocytes (Facial Subcutaneous White Adipose), Subcutaneous White Adipocytes (Body Subcutaneous White Adipose)      fully expand to see all 6 cells

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
GO:0005515protein binding ----
GO:0008083growth factor activity IEA--
GO:0051428peptide hormone receptor binding IEA--
Find genes that share ontologies with LEP           About GenesLikeMe

     Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Lep) (see all 24):
 adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
 embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
 immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

Find genes that share phenotypes with LEP           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for LEP

    Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

CRISPR Knockouts: 
   OriGene CRISPR knockouts for LEP

Block miRNA regulation of human, mouse, rat LEP using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LEP (see all 24):
hsa-miR-498 hsa-miR-29a hsa-miR-29c hsa-miR-128 hsa-miR-27b* hsa-miR-9 hsa-miR-1276 hsa-miR-298
SwitchGear 3'UTR luciferase reporter plasmidLEP 3' UTR sequence
Inhib. RNA
OriGene RNAi products in human, mouse, rat for LEP
Predesigned siRNA for gene silencing in human, mouse, rat LEP

OriGene clones in human, mouse for LEP (see all 6)
OriGene ORF clones in mouse, rat for LEP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LEP (NM_000230)
Sino Biological Human cDNA Clone for LEP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEP

Cell Line
GenScript Custom overexpressing Cell Line Services for LEP
Browse ESI BIO Cell Lines and PureStem Progenitors for LEP 
In Situ Assay

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEP

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot
LEP_HUMAN, P41159: Secreted
Subcellular locations from COMPARTMENTS: 

endoplasmic reticulum2
plasma membrane2
golgi apparatus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space ISS--
GO:0005737cytoplasm IEA--

Find genes that share ontologies with LEP           About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for LEP About   (see all 22)  
See pathways by source

SuperPathContained pathways About
1Incretin Synthesis, Secretion, and Inactivation
Incretin Synthesis, Secretion, and Inactivation0.88
Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.88
2Peptide hormone metabolism
Peptide hormone metabolism0.30
Synthesis, Secretion, and Deacylation of Ghrelin0.00
3L1CAM interactions
Developmental Biology0.63
4Signaling by GPCR
Signal Transduction0.58
5PEDF Induced Signaling
Cytokine-cytokine receptor interaction0.43

Find genes that share SuperPaths with LEP           About GenesLikeMe

Pathways by source                                   See SuperPaths
Show all pathways

1 R&D Systems Pathway for LEP
    Adipocytokines & Insulin Signaling

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for LEP
    AMPK Enzyme Complex Pathway

2 GeneGo (Thomson Reuters) Pathways for LEP
    Development Leptin signaling via JAK/STAT and MAPK cascades
Development Leptin signaling via PI3K-dependent pathway

Selected BioSystems Pathways for LEP (see all 6)
AMPK signaling
Spinal Cord Injury
Leptin signaling pathway
Signaling events mediated by PTP1B

4 Reactome Pathways for LEP
    Synthesis, secretion, and deacylation of Ghrelin
Transcriptional regulation of white adipocyte differentiation
Signaling by Leptin
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

5 Kegg Pathways  (Kegg details for LEP):
    Cytokine-cytokine receptor interaction
Neuroactive ligand-receptor interaction
Jak-STAT signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)

    Pathway & Disease-focused RT2 Profiler PCR Arrays including LEP (see all 10): 
          Insulin Signaling Pathway in human mouse rat
          Growth Factors in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
          Angiogenesis in human mouse rat


    GeneGlobe Interaction Network for LEP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for LEP (P411593 ENSP000003126524) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
InteractantInteraction Details
GeneCardExternal ID(s)
PRKAA2P546463, ENSP000003602904I2D: score=1 STRING: ENSP00000360290
UCNP550893, ENSP000002960994I2D: score=1 STRING: ENSP00000296099
LEPRP483573, ENSP000003303934I2D: score=2 STRING: ENSP00000330393
A2MP010233, ENSP000003239294I2D: score=2 STRING: ENSP00000323929
CRPP027413, ENSP000002550304I2D: score=1 STRING: ENSP00000255030
About this table

Gene Ontology (GO): Selected biological process terms (see all 60):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0001542ovulation from ovarian follicle IEA--
GO:0001666response to hypoxia IEA--
GO:0001819positive regulation of cytokine production IEA--
GO:0001890placenta development IDA17957153

Find genes that share ontologies with LEP           About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for LEP available from Tocris Bioscience    About this table
CompoundAction CAS #
LEP (116-130) (mouse)Synthetic leptin peptide fragment[258276-95-8]

1 HMDB Compound for LEP    About this table
CompoundSynonyms CAS #PubMed Ids
Androstenedione(4)-Androsten-3,17-dione (see all 14)63-05-811824514

Selected Novoseek inferred chemical compound relationships for LEP gene (see all 130)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 84.8 1892 10411236 (8), 10411242 (8), 17170237 (7), 15814535 (6) (see all 99)
c-peptide 71.5 169 12752073 (4), 16365005 (4), 19475640 (4), 15196417 (4) (see all 99)
lipid 70.7 531 16737635 (6), 15543224 (5), 11502793 (5), 19169663 (4) (see all 99)
testosterone 70.6 677 18462615 (11), 11244464 (9), 9253326 (7), 11228760 (6) (see all 99)
cholesterol 70.4 648 15555610 (7), 16324751 (7), 11447020 (6), 17884293 (6) (see all 99)
estradiol 67.6 321 9768648 (9), 11791088 (6), 9482922 (5), 11599235 (4) (see all 99)
dehydroepiandrosterone sulfate 63.4 91 10561001 (3), 12647279 (3), 11820328 (2), 17198487 (2) (see all 52)
orlistat 61.4 19 18846024 (3), 20119816 (2), 19409578 (2), 18457636 (1) (see all 6)
fatty acid 61 162 16822822 (4), 11342529 (3), 11404229 (3), 15919610 (3) (see all 99)
metformin 59.5 71 15531718 (6), 11436194 (4), 15983226 (3), 11289473 (3) (see all 37)

2 PharmGKB related drug/compound annotations for LEP gene    About this table
Drug/compound PharmGKB Annotation

Find genes that share compounds with LEP           About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for LEP gene (2 alternative transcripts): 
NM_000230.2  XM_005250340.2  

Unigene Cluster for LEP:

Hs.194236  [show with all ESTs]
Unigene Representative Sequence: NM_000230
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000308868(uc003vml.2 uc003vmm.2)
Block miRNA regulation of human, mouse, rat LEP using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LEP (see all 24):
hsa-miR-498 hsa-miR-29a hsa-miR-29c hsa-miR-128 hsa-miR-27b* hsa-miR-9 hsa-miR-1276 hsa-miR-298
SwitchGear 3'UTR luciferase reporter plasmidLEP 3' UTR sequence
Inhib. RNA
OriGene RNAi products in human, mouse, rat for LEP
Predesigned siRNA for gene silencing in human, mouse, rat LEP
OriGene clones in human, mouse for LEP (see all 6)
OriGene ORF clones in mouse, rat for LEP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LEP (NM_000230)
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEP
OriGene qPCR primer pairs and template standards for LEP
OriGene qSTAR qPCR primer pairs in human, mouse for LEP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LEP
  QuantiTect SYBR Green Assays in human, mouse, rat LEP
  QuantiFast Probe-based Assays in human, mouse, rat LEP

Additional mRNA sequence: 

AF008123.1 AK313553.1 BC060830.1 BC069323.1 BC069452.1 BC069527.1 D49487.1 U18915.1 

1 DOTS entry:


Selected AceView cDNA sequences (see all 25):

BQ012637 U18915 BU752306 BC069323 BC060830 R62951 BC069452 AF008123 
BC069527 NM_000230 U43653 BX479630 BX098617 AA320865 BQ019411 CB995210 
R63003 N56684 D49487 H39701 H42529 H42528 CB265926 CB995927 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for LEP    About this scheme

ExUns: 1a · 1b ^ 2a · 2b

ECgene alternative splicing isoforms for LEP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LEP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
LEP Expression
About this image

LEP expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 Adipose (Muscoskeletal System)    fully expand to see all 11 entries
         Subcutaneous White Adipocytes Cranial Subcutaneous White Adipose
         Body Subcutaneous White Adipose
 Umbilical Cord (Extraembryonic Tissues)
         Umbilical Arteries
 Bone (Muscoskeletal System)
         Notch-transfected mesenchymal stromal cells (SB623)
 Mesenchymal Stem Cells
         Notch-transfected mesenchymal stromal cells (SB623)
 Placenta (Extraembryonic Tissues)
LEP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LEP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.194236
    Pathway & Disease-focused RT2 Profiler PCR Arrays including LEP (see all 10): 
          Insulin Signaling Pathway in human mouse rat
          Growth Factors in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
          Angiogenesis in human mouse rat

OriGene qPCR primer pairs and template standards for LEP
OriGene qSTAR qPCR primer pairs in human, mouse for LEP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LEP
QuantiTect SYBR Green Assays in human, mouse, rat LEP
QuantiFast Probe-based Assays in human, mouse, rat LEP
In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LEP gene from Selected species (see all 9)    About this table
Organism Taxonomic
Gene Description Human
(Mus musculus)
Mammalia Lep1 , 5 leptin1, 5 82.63(n)1
  6 (12.30 cM)5
168461  NM_008493.31  NP_032519.11 
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004867151 leptin-like 49.9(n)
  100486715  XM_002931835.2  XP_002931881.2 
(Danio rerio)
Actinopterygii lepa6
leptin a
1 ↔ 1
18(10137808-10138401) ENSDARG00000091085

ENSEMBL Gene Tree for LEP (if available)
TreeFam Gene Tree for LEP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
About This Section


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for LEP (see all 616)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
Chr 7 posSequence#AA
CLeptin deficiency (LEPD)4 pathogenic1131237807(+) ACCTCC/TGGGAT 2 R W mis10--------
C--127267454(-) TAATC-/TG/   
1 -- int12NA 4
C,F--127882006(+) AATGA-/AAT   
1 -- int12NS 92
C--127884139(+) AAAAAA/-GTAAC 1 -- int1 trp31Minor allele frequency- -:0.00CSA 2
C--127884300(+) CACAC-/ACAC  
1 -- int10--------
C--127884300(+) CCCTG-/ACACACAC
1 -- int10--------
C--127884300(+) CCCTG-/ACACAC
1 -- int10--------
--131222519(+) GAATGC/TCTATC 1 -- us2k10--------
C,F,A,H--131222528(+) tcctaC/Tgcaat 1 -- us2k17Minor allele frequency- T:0.06EA NS NA WA 540
C,F--131222529(+) CCTACG/ACAATG 1 -- us2k12Minor allele frequency- A:0.11WA 120

HapMap Linkage Disequilibrium report for LEP (127881331 - 127897682 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for LEP:    About this table    
Variant IDTypeSubtypePubMed ID
esv33413CNV Gain17666407

Human Gene Mutation Database (HGMD): LEP
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LEP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 164160   
OMIM disorders: 614962  
UniProtKB/Swiss-Prot: LEP_HUMAN, P41159
  • Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe
    hyperphagia and intractable obesity from an early age. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for LEP (see all 41):    
    About MalaCards
    congenital leptin deficiency    diencephalic syndrome    leptin deficiency    sleep apnea
    obstructive sleep apnea    sick building syndrome    obesity    anorexia nervosa
    fetal macrosomia    overnutrition    type 2 diabetes mellitus    pre-eclampsia
    alstrom syndrome    metabolic syndrome x    morbid obesity    skin tag
    lipoblastoma    insulin resistance    lipoatrophic diabetes    acquired generalized lipodystrophy

    Selected inferred disease relationships from the University of Copenhagen DISEASES database for LEP (see all 23):
    Diabetes mellitus     Hyperinsulinism     Morbid obesity     Hypertension
    Hyperglycemia     Lipodystrophy     Fatty liver disease     Polycystic ovary syndrome
    Atherosclerosis     Eating disorder     Amenorrhea     Hypogonadism
    Infertility     Heart disease     Osteoporosis     Kidney failure
    Prader-Willi syndrome     Breast cancer     Rabies     Hyperandrogenism

    Find genes that share disorders with LEP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LEP gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 93.7 2301 10722859 (6), 16782141 (6), 15793852 (6), 17147067 (5) (see all 99)
    insulin resistance 91.6 952 17093174 (6), 18521457 (5), 19781705 (5), 12485522 (5) (see all 99)
    insulin sensitivity 87.1 401 9876349 (8), 9385530 (5), 17413885 (4), 19269197 (4) (see all 99)
    hyperinsulinemia 79.1 151 17236585 (4), 9820061 (3), 17085442 (3), 15855322 (2) (see all 99)
    anorexia nervosa 78 154 17304762 (7), 11919545 (4), 9169091 (4), 9177394 (3) (see all 97)
    lipodystrophy 73.7 107 19727665 (5), 11856796 (4), 18348717 (4), 15356018 (3) (see all 51)
    polycystic ovary syndrome 72.9 112 11502810 (8), 12921548 (2), 17062953 (2), 18756827 (2) (see all 72)
    acquired generalized lipodystrophy 70.5 4 15256772 (1), 18076675 (1), 11994394 (1), 12502655 (1)
    lipodystrophy, congenital generalized 69.4 19 17118991 (4), 15983199 (3), 11994394 (2), 12502655 (2) (see all 12)
    niddm 68.3 128 2010535 (6), 8636448 (3), 9283801 (3), 8621021 (3) (see all 70)

    Genetic Association Database (GAD): LEP
    Human Genome Epidemiology (HuGE) Navigator: LEP (162 documents)

    Export disorders for LEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LEP gene, integrated from 10 sources (see all 4624) (see top 10):
    (articles sorted by number of sources associating them with LEP)

    1. Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. (PubMed id 8621021)1, 2, 4, 9 Niki T.... Kasuga M. (Diabetes 1996)
    2. Genotype x nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake. (PubMed id 19747414)1, 4, 9 BienertovA!-VaskA^ J....VaskA^ A. (Br. J. Nutr. 2010)
    3. Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. (PubMed id 19697123)1, 4, 9 Cleveland R.J....Santella R.M. (Breast Cancer Res. Treat. 2010)
    4. Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. (PubMed id 18564365)1, 4, 9 Han H.R....Park K.S. (Clin. Genet. 2008)
    5. Leptin gene (TTTC)(n) microsatellite polymorphism as well as leptin receptor R223Q and PPARgamma2 P12A substitutions are not associated with hypertensive disorders in pregnancy. (PubMed id 20070288)1, 4, 9 Wiedemann A....Toth B. (Am. J. Reprod. Immunol. 2010)
    6. Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. (PubMed id 19337797)1, 4, 9 BienertovA!-VaskA^ J.A....VaskA^ A. (Heart Vessels 2009)
    7. Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins. (PubMed id 18490929)1, 4, 9 Souren N.Y....Zeegers M.P. (Int J Obes (Lond) 2008)
    8. Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. (PubMed id 18716353)1, 4, 9 Mizuta E....Morisaki T. (Hypertens. Res. 2008)
    9. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. (PubMed id 16504019)1, 4, 9 Snoussi K....Chouchane L. (BMC Cancer 2006)
    10. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. (PubMed id 15760495)1, 4, 9 Poitou C....ClAcment K. (Obes Surg 2005)
    11. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. (PubMed id 15161768)1, 4, 9 Lakka T.A....Bouchard C. (Diabetes 2004)
    12. Congenital leptin deficiency is associated with severe early-onset obesity in humans. (PubMed id 9202122)1, 4, 9 Montague C.T....O'Rahilly S. (Nature 1997)
    13. Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescents. (PubMed id 19873684)1, 4, 9 Calarge C.A....Schlechte J.A. (Psychiatr. Genet. 2009)
    14. Leptin gene (TTTC)(n) microsatellite polymorphism in pre-eclampsia and HELLP syndrome. (PubMed id 19634986)1, 4, 9 Nagy B....Rigo J. (Clin. Chem. Lab. Med. 2009)
    15. [The (-2548G/A) polymorphism of leptin gene in women with gestational hypertension and preeclampsia]. (PubMed id 18624112)1, 4, 9 Drews K....Mrozikiewicz P.M. (Ginekol. Pol. 2008)
    16. No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population. (PubMed id 18510797)1, 4, 9 Bienertova-Vasku J....Vasku A. (Nutr Neurosci 2008)
    17. Leptin and leptin receptor gene polymorphisms in obstructive sleep apnea syndrome. (PubMed id 17989154)1, 4, 9 Hanaoka M....Kubo K. (Chest 2008)
    18. Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophrenia. (PubMed id 17285096)1, 4, 9 Ellingrod V.L....Miller D.D. (Psychopharmacol Bull 2007)
    19. Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. (PubMed id 17587397)1, 4, 9 Hart Sailors M.L....Bray M.S. (amp 2007)
    20. Site -2548 of the leptin gene is associated with gender-specific trends in newborn size and cord leptin levels. (PubMed id 17852540)1, 4, 9 Adkins R.M....Morrison J.C. (Int J Pediatr Obes 2007)
    21. Association of leptin genetic polymorphism -2548 G/A with gestational diabetes mellitus. (PubMed id 18850205)1, 4, 9 VaskA_ J.A....Bienert P. (amp 2006)
    22. Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease. (PubMed id 16261186)1, 4, 9 Porreca E....Stuppia L. (Int J Obes (Lond) 2006)
    23. Evaluation of leptin level and Ob gene polymorphism in patients with Behcet's disease. (PubMed id 16786343)1, 4, 9 Okudan N....Sari F. (Arch. Dermatol. Res. 2006)
    24. Leptin, soluble leptin receptor and leptin gene polymorphism in relation to preeclampsia risk. (PubMed id 15544427)1, 4, 9 Muy-Rivera M....Williams M.A. (Physiol Res 2005)
    25. G(-2548)A leptin gene polymorphism in obese subjects is associated with serum leptin concentration and bone mass. (PubMed id 20502402)1, 4, 9 Franek E....Wiecek A. (Pol. Arch. Med. Wewn. 2010)
    26. Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa. (PubMed id 20140086)1, 4, 9 Okpechi I.G....Ramesar R. (PLoS ONE 2010)
    27. Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes? (PubMed id 18958929)1, 4, 9 BienertovA!-VaskA^ J....Unzeitig V. (J. Obstet. Gynaecol. Res. 2008)
    28. Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes. (PubMed id 18681781)1, 4, 9 Srivastava V....Thelma B. (Pharmacogenomics 2008)
    29. Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. (PubMed id 18398047)1, 4, 9 Doecke J.D....Whiteman D.C. (amp 2008)
    30. Are common leptin promoter polymorphisms associated with restenosis after coronary stenting? (PubMed id 17879022)1, 4, 9 BienertovA!-VaskA^ J.A....VaskA^ A. (Heart Vessels 2007)
    31. Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. (PubMed id 17502770)1, 4, 9 Zhang X.Y....Kosten T.R. (J Clin Psychopharmacol 2007)
    32. Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications. (PubMed id 16932309)1, 3, 9 Brennan A.M. and Mantzoros C.S. (amp 2006)
    33. The LEP gene and age of menarche: maternal age as a potential cause of hidden stratification in association studies. (PubMed id 11461187)1, 4, 9 Comings D.E....MacMurray J.P. (Mol. Genet. Metab. 2001)
    34. The A19G polymorphism in the 5' untranslated region of the human obese gene does not affect leptin levels in severely obese patients. (PubMed id 11061506)1, 4, 9 Lucantoni R....Di Blasio A.M. (J. Clin. Endocrinol. Metab. 2000)
    35. A leptin missense mutation associated with hypogonadism and morbid obesity. (PubMed id 9500540)1, 2, 9 Strobel A.... Strosberg A.D. (Nat. Genet. 1998)
    36. Crystal structure of the obese protein leptin-E100. (PubMed id 9144295)1, 2, 9 Zhang F.... Schevitz R.W. (Nature 1997)
    37. Positional cloning of the mouse obese gene and its human homologue. (PubMed id 7984236)1, 2, 9 Zhang Y.... Friedman J.M. (Nature 1994)
    38. Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample. (PubMed id 20504252)1, 4 Opgen-Rhein C....Dettling M. (Pharmacogenomics 2010)
    39. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    40. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    41. Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people. (PubMed id 20492333)1, 4 Zhou Y.J....Huang H.L. (J. Gastroenterol. Hepatol. 2010)
    42. Family-based analysis of candidate genes for polycystic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (J. Clin. Endocrinol. Metab. 2010)
    43. [The influence of metabolic parameters on fetal development weight in women with type 1 diabetes and homozygotic variant in -2548 G/A of leptin gene and its 668 A/G receptor polymorphism]. (PubMed id 20873117)1, 4 Iciek R....Brazert J. (Ginekol. Pol. 2010)
    44. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    45. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    46. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    47. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    48. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    49. Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. (PubMed id 20642810)1, 4 Friedlander Y....Siscovick D.S. (Ann. Hum. Genet. 2010)
    50. Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals. (PubMed id 20520958)1, 4 Hinuy H.M....Hirata R.D. (Arq Bras Endocrinol Metabol 2010)
    51. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1, 4 Larkin E.K....Redline S. (Am. J. Respir. Crit. Care Med. 2010)
    52. Contrasting association of a non-synonymous leptin receptor gene polymorphism with Wegener's granulomatosis and Churg-Strauss syndrome. (PubMed id 20185531)1, 4 Wieczorek S....Epplen J.T. (Rheumatology (Oxford) 2010)
    53. Association of -2548 G/A polymorphism in the leptin gene with preeclampsia/pregnancy-induced hypertension. (PubMed id 20462372)1, 4 Sugathadasa B.H....Wijesundere A.P. (Hypertens Pregnancy 2010)
    54. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    55. Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects. (PubMed id 19913498)1, 4 Constantin A....Popov D.L. (Biochem. Biophys. Res. Commun. 2010)
    56. Influence of the leptin G-2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents. (PubMed id 20597904)1, 4 Riestra P....GarcAcs C. (Ann. Hum. Genet. 2010)
    57. Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: a case-control study. (PubMed id 20664554)1, 4 Qin J....Jiang Q. (J. Hum. Genet. 2010)
    58. Obesity and polycystic ovary syndrome: association with androgens, leptin and its genotypes. (PubMed id 20500101)1, 4 Pusalkar M....Maitra A. (Gynecol. Endocrinol. 2010)
    59. The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders. (PubMed id 20183928)1, 4 Furusawa T....Ohashi J. (Hum. Genet. 2010)
    60. Impact of leptin and leptin-receptor gene polymorphisms on serum lipids in Japanese obese children. (PubMed id 20222875)1, 4 Okada T....Arisaka O. (Acta Paediatr. 2010)
    61. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    62. Genetic variation in adipokine genes and risk of colorectal cancer. (PubMed id 19273568)1, 4 Pechlivanis S....FAPrsti A. (Eur. J. Endocrinol. 2009)
    63. Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. (PubMed id 19760027)1, 4 Tsilidis K.K....Platz E.A. (amp 2009)
    64. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    65. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    66. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    67. Leptin--2548 g/A polymorphism in endometrial cancer. (PubMed id 19886360)1, 4 Chovanec J....DostA!lovA! Z. (Klin Onkol 2009)
    68. Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer. (PubMed id 18855010)1, 4 Yapijakis C....Vairaktaris E. (J. Cancer Res. Clin. Oncol. 2009)
    69. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    70. Genetic variation in D7S1875 repeat polymorphism of leptin gene is associated with increased risk for depression: a case-control study from India. (PubMed id 19382181)1, 4 Kapoor M....Sidhu S. (Depress Anxiety 2009)
    71. Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. (PubMed id 18992263)1, 4 Slattery M.L....Samowitz W.S. (Mutat. Res. 2009)
    72. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (Pharmacogenomics 2009)
    73. Adipokine genes and prostate cancer risk. (PubMed id 19035456)1, 4 Moore S.C....Gunter M.J. (Int. J. Cancer 2009)
    74. Are genes associated with energy metabolism important in asthma and BMI? (PubMed id 19191138)1, 4 Szczepankiewicz A....Popiel A. (J Asthma 2009)
    75. Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. (PubMed id 19204185)1, 4 Ma D....Borecki I.B. (Hypertension 2009)
    76. Polymorphisms of the LEP- and LEPR gene and obesity in patients using antipsychotic medication. (PubMed id 19142102)1, 4 Gregoor J.G....Heerdink E.R. (J Clin Psychopharmacol 2009)
    77. Association study between candidate genes and obesity-related phenotypes using a sample of lumberjacks. (PubMed id 19367093)1, 4 Chamberland A....Laprise C. (Public Health Genomics 2009)
    78. Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche. (PubMed id 19506390)1, 4 Rothenbuhler A....Fradin D. (Horm. Res. 2009)
    79. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    80. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. (PubMed id 19723917)1, 4 Teras L.R....Feigelson H.S. (amp 2009)
    81. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. (PubMed id 19267370)1, 4 Wang M.H....Platz E.A. (Prostate 2009)
    82. Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. (PubMed id 19077438)1, 4 Chung W.K....Tiwari H.K. (Hum. Hered. 2009)
    83. Association of a common variant of the leptin gene with blood pressure in an obese Brazilian population. (PubMed id 19229195)1, 4 Genelhu V.A....Francischetti E.A. (Am. J. Hypertens. 2009)
    84. Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients. (PubMed id 19041299)1, 4 Ben Ali S....Kaabachi N. (Clin. Biochem. 2009)
    85. Genetic association study of selected candidate genes (ApoB, LPL, Leptin) and telomere length in obese and hypertensive individuals. (PubMed id 19772655)1, 4 Das B....Seshadri M. (BMC Med. Genet. 2009)
    86. Pharmacogenetic contribution of leptin gene polymorphism in cutaneous T-cell lymphoma. (PubMed id 19079651)1, 4 Vasku V....Vasku J.B. (Int J Clin Exp Pathol 2009)
    87. Identification of leptin gene variants in school children with early onset obesity. (PubMed id 20232565)1, 4 Kongmacheep P....Hancharoen K. (J Med Assoc Thai 2009)
    88. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    89. Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese. (PubMed id 19491387)1, 4 Chen H.H....Pan W.H. (Am. J. Clin. Nutr. 2009)
    90. [-2548G/A functional polymorphism in the promoter region of leptin gene and antipsychotic agent-induced weight gain in schizophrenic patients: a study of nuclear family-based association]. (PubMed id 18460775)1, 4 Mou X.D....Sun J. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008)
    91. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (PLoS ONE 2008)
    92. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    93. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    94. Leptin gene, leptin gene receptor polymorphisms and body weight in pregnant women with type 1 diabetes mellitus. (PubMed id 18939509)1, 4 Iciek R....Pietryga M. (Ginekol. Pol. 2008)
    95. Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses. (PubMed id 18828733)1, 4 Souren N.Y....Paulussen A.D. (Twin Res Hum Genet 2008)
    96. Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. (PubMed id 18059035)1, 4 Slattery M.L....Potter J.D. (Int. J. Cancer 2008)
    97. Leptin gene, leptin gene polymorphisms and body weight in pregnant women with diabetes mellitus type I. (PubMed id 18955751)1, 4 Iciek R....Brazert J. (J. Physiol. Pharmacol. 2008)
    98. Genetic risk factors for renal failure among north Indian ESRD patients. (PubMed id 18242170)1, 4 Tripathi G....Agrawal S. (Clin. Biochem. 2008)
    99. Microsatellite polymorphism of the human leptin gene and risk of obesity. (PubMed id 18725053)1, 4 Gardezi A.Z....Marashi S.M. (J Crit Care 2008)
    100. Possible association between the -2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain. (PubMed id 17804136)1, 4 Kang S.G....Kim L. (amp 2008)
    101. The -2548G/A LEP polymorphism is associated with blood pressure in Tunisian obese patients. (PubMed id 18923972)1, 4 Ben Ali S....Kaabachi N. (Blood Press. 2008)
    102. Lack of association between the G-2548A polymorphism of the leptin gene and psoriasis in a Turkish population. (PubMed id 18173522)1, 4 Kara N....Turanli A.Y. (Int. J. Dermatol. 2007)
    103. Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. (PubMed id 17192493)1, 4 de Krom M....Adan R. (Diabetes 2007)
    104. Contribution of several candidate gene polymorphisms in the determination of adiposity changes: results from the QuAcbec Family Study. (PubMed id 17299381)1, 4 Bouchard L....PAcrusse L. (Int J Obes (Lond) 2007)
    105. LEPR p.Q223R, beta3-AR p.W64R and LEP c.-2548G&gt;A gene variants in obese Brazilian subjects. (PubMed id 18273796)1, 4 Duarte S.F....Pimentel M.M. (Genet. Mol. Res. 2007)
    106. Lack of association between leptin G2548A gene polymorphism and BehAset's disease. (PubMed id 17207170)1, 4 Aydin F....Turanli A.Y. (J Eur Acad Dermatol Venereol 2007)
    107. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. (PubMed id 16571841)1, 4 Wang T.N....Ko Y.C. (Obesity (Silver Spring) 2006)
    108. A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer. (PubMed id 16630717)1, 4 Ribeiro R....Medeiros R. (Eur. J. Cancer 2006)
    109. Phenotypic variation in constitutional delay of growth and puberty: relationship to specific leptin and leptin receptor gene polymorphisms. (PubMed id 16793957)1, 4 Banerjee I....Clayton P.E. (Eur. J. Endocrinol. 2006)
    110. Lack of association between the tetranucleotide repeat polymorphism in the 3'-flanking region of the leptin gene and hypertension in severely obese patients. (PubMed id 17114907)1, 4 Maestrini S....Di Blasio A.M. (J. Endocrinol. Invest. 2006)
    111. Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the QuAcbec Family Study. (PubMed id 16231024)1, 4 Loos R.J....Bouchard C. (Int J Obes (Lond) 2006)
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    381. Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population. (PubMed id 17016694)1, 9 Jamshidi Y....O'Dell S.D. (Diabetologia 2006)
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    384. Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in children. (PubMed id 17679810)1, 9 Kelly A.S....Dengel D.R. (J Cardiometab Syndr 2006)
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    444. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. (PubMed id 23895348)1 Bonda D.J....Lee H.G. (J. Neurochem. 2014)
    445. The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer. (PubMed id 23593308)1 Liu L....Nie S. (PLoS ONE 2013)
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    448. Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children. (PubMed id 23318644)1 Ko B.J....Kim S.M. (Endocr. J. 2013)
    449. Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology. (PubMed id 23570606)1 Stringer E.A....Younger J.W. (J Transl Med 2013)
    450. Leptin, adiponectin, resistin, visfatin serum levels and idiopathic recurrent pericarditis: biomarkers of disease activity? A preliminary report. (PubMed id 23137677)1 Cantarini L....Fioravanti A. (Clin. Exp. Rheumatol. 2013)
    451. Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects. (PubMed id 23666343)1 Bucci L....Salvioli S. (Biogerontology 2013)
    452. A rightward shift of the distribution of fasting and post-load glucose in northern Sweden between 1990 and 2009 and its predictors. Data from the Northern Sweden MONICA study. (PubMed id 23586854)1 Lilja M....SAPderberg S. (Diabet. Med. 2013)
    453. Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: leptin resistance mediated by antihistaminergic activity? (PubMed id 23277262)1 Schilling C....Deuschle M. (J Clin Psychopharmacol 2013)
    454. Abdominal adiposity through adipocyte secretion products, a risk factor for endometrial cancer. (PubMed id 23544715)1 Mihu D....Mihu C.M. (Gynecol. Endocrinol. 2013)
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    463. Ghrelin, leptin and insulin in cirrhotic children and adolescents: relationship with cirrhosis severity and nutritional status. (PubMed id 23142314)1 Dornelles C.T....Silveira T.R. (Regul. Pept. 2013)
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    465. Leptin and endothelial function in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. (PubMed id 23591414)1 Gonzalez M....SAPderberg S. (Atherosclerosis 2013)
    466. Transcriptional patterns in peritoneal tissue of encapsulating peritoneal sclerosis, a complication of chronic peritoneal dialysis. (PubMed id 23418565)1 Reimold F.R....Alper S.L. (PLoS ONE 2013)
    467. Obesity-associated adipokines correlate with survival in epithelial ovarian cancer. (PubMed id 23402904)1 Diaz E.S....Li A.J. (Gynecol. Oncol. 2013)
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    482. High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells. (PubMed id 23484124)1 Tsiotra P.C....Raptis S.A. (Biomed Res Int 2013)
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    517. Physical activity attenuates the negative effect of low birth weight on leptin levels in European adolescents; the HELENA study. (PubMed id 22397877)1 Labayen I....Ruiz J.R. (Nutr Metab Cardiovasc Dis 2013)
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    519. Circulating insulin and leptin in women with and without premenstrual disphoric disorder in the menstrual cycle. (PubMed id 23461756)1 Akturk M....Arslan M. (Gynecol. Endocrinol. 2013)
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    527. Changes in children's sleep duration on food intake, weight, and leptin. (PubMed id 24190680)1 Hart C.N....Wing R. (Pediatrics 2013)
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    533. Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion. (PubMed id 23354307)1 Dong Z....Wang C. (Carcinogenesis 2013)
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    536. Leptin and HER-2 are associated with gastric cancer progression and prognosis of patients. (PubMed id 22883999)1 Geng Y....Yin Y. (amp 2012)
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    538. Circulating levels of adiponectin, leptin, fetuin-A and retinol-binding protein in patients with tuberculosis: markers of metabolism and inflammation. (PubMed id 22685600)1 Keicho N....Lien L.T. (PLoS ONE 2012)
    539. The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women. (PubMed id 22981830)1 Zhao H.Y....Liu J.M. (Clin. Biochem. 2012)
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    543. Association between adipocytokines and insulin resistance in Indian hypertensive patients. (PubMed id 22572423)1 Mahadik S.R. (Indian Heart J 2012)
    544. Leptin promoter G-2548A genotypes and associated serum leptin levels in childhood acute leukemia at diagnosis and under high-dose steroid therapy. (PubMed id 21955253)1 Tavil B....Gurgey A. (amp 2012)
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    546. Effect of three common SNPs in 5'-flanking region of LEP and ADIPOQ genes on their expression in Polish obese children and adolescents. (PubMed id 21755292)1 Cieslak J....Switonski M. (Mol. Biol. Rep. 2012)
    547. Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis. (PubMed id 21848410)1 Malhotra N....Kumar S. (Gynecol. Endocrinol. 2012)
    548. Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin II in cultured human coronary artery smooth muscle cells. (PubMed id 21806545)1 Shyu K.G....Hung H.F. (Clin. Sci. 2012)
    549. Evaluation of serum adipokines in peripheral arterial occlusive disease. (PubMed id 22547903)1 Gherman C.D. and Mironiuc A.I. (Mediators Inflamm. 2012)
    550. Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy. (PubMed id 22364914)1 Veloso S....Vidal F. (Cytokine 2012)
    551. Leptin regulates dopamine responses to sustained stress in humans. (PubMed id 23115175)1 Burghardt P.R....Zubieta J.K. (J. Neurosci. 2012)
    552. Expression and release of leptin and proinflammatory cytokines in patients with ulcerative colitis and infectious diarrhea. (PubMed id 23211301)1 Biesiada G....Mach T. (J. Physiol. Pharmacol. 2012)
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    555. Polymorphisms in adiposity-related genes are associated with age at menarche and menopause in breast cancer patients and healthy women. (PubMed id 22537818)1 Kim K.Z....Lee E.S. (Hum. Reprod. 2012)
    556. Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype. (PubMed id 22773729)1 Lugogo N.L....Kraft M. (Am. J. Respir. Crit. Care Med. 2012)
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    558. Hyperleptinemia is associated with hypertension, systemic inflammation and insulin resistance in overweight but not in normal weight men. (PubMed id 21920718)1 Galletti F....Strazzullo P. (Nutr Metab Cardiovasc Dis 2012)
    559. Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis. (PubMed id 22615788)1 Liang G....Huang D. (PLoS ONE 2012)
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    561. Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension. (PubMed id 22362850)1 Huertas A....Humbert M. (Eur. Respir. J. 2012)
    562. Involvement of adipokines, AMPK, PI3K and the PPAR signaling pathways in ovarian follicle development and cancer. (PubMed id 23417417)1 Dupont J....RamAc C. (Int. J. Dev. Biol. 2012)
    563. Reactive leptin resistance and the profile of platelet activation in acute ischaemic stroke patients. (PubMed id 22627503)1 Lukasik M....Kozubski W. (Thromb. Haemost. 2012)
    564. Relationship of adiponectin and leptin to coronary artery disease, classical cardiovascular risk factors and atherothrombotic biomarkers in the IARS cohort. (PubMed id 22955445)1 Shanker J....Kakkar V.V. (Thromb. Haemost. 2012)
    565. Central obesity, leptin and cognitive decline: the Sacramento Area Latino Study on Aging. (PubMed id 22814127)1 Zeki Al Hazzouri A....Neuhaus J. (Dement Geriatr Cogn Disord 2012)
    566. Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations. (PubMed id 22392590)1 Rossi I.A....TaffAc P. (Eur. J. Epidemiol. 2012)
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    568. Evaluation of leptin levels among fibromyalgia patients before and after three months of treatment, in comparison with healthy controls. (PubMed id 22518370)1 Ablin J.N....Levartovsky D. (amp 2012)
    569. Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions. (PubMed id 21952038)1 Wrann C.D....Nave H. (Am. J. Physiol. Endocrinol. Metab. 2012)
    570. Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain. (PubMed id 22426215)1 Brandl E.J....Puls I. (amp 2012)
    571. Circulatory and adipose tissue leptin and adiponectin in relationship to resting energy expenditure in patients with chronic obstructive pulmonary disease. (PubMed id 22881231)1 BrA_sik M....TkA!A8ovA! R. (Physiol Res 2012)
    572. Relationship between adipokines and coronary artery aneurysm in children with Kawasaki disease. (PubMed id 22683371)1 Liu R....Yi Q. (Transl Res 2012)
    573. Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes. (PubMed id 23285079)1 Conde J....Gualillo O. (PLoS ONE 2012)
    574. Adiponectin and leptin systems in human endometrium during window of implantation. (PubMed id 22265003)1 Dos Santos E....DieudonnAc M.N. (Fertil. Steril. 2012)
    575. Leptin, leptin gene and leptin receptor gene polymorphism in heart failure with preserved ejection fraction. (PubMed id 21584748)1 Abd El-Aziz T.A....Pasha H.F. (Heart Vessels 2012)
    576. Cytokine profile, metabolic syndrome and cardiovascular disease risk in women with late-onset gestational diabetes mellitus. (PubMed id 22200508)1 LA^pez-Tinoco C....Bartha J.L. (Cytokine 2012)
    577. Serum adiponectin, resistin, leptin concentration and central adiposity parameters in Barrett's esophagus patients with and without intestinal metaplasia in comparison to healthy controls and patients with GERD. (PubMed id 22944288)1 Mokrowiecka A....Malecka-Panas E. (Hepatogastroenterology 2012)
    578. Induction of insulin resistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes. (PubMed id 22491740)1 Gerrits A.J....Akkerman J.W. (Haematologica 2012)
    579. Association between umbilical cord leptin and weight gain according to feeding type in the early postnatal period, a brief report. (PubMed id 23593779)1 TreviA+o-Garza C....Argente J. ( organo del Hospital de Enfermedades de la NutriciĆ³n 2012)
    580. Leptin and adiponectin: distribution and associations with cardiovascular risk factors in men and women of the general population. (PubMed id 22508240)1 Andreasson A.N....Brismar K. (Am. J. Hum. Biol. 2012)
    581. Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. (PubMed id 22734460)1 Boumaiza I....Bouslama A. (Genet Test Mol Biomarkers 2012)
    582. Human skeletal muscle releases leptin in vivo. (PubMed id 23010500)1 Wolsk E....van Hall G. (Cytokine 2012)
    583. Polymorphisms in the 3'UTR of the human leptin gene and their role in hypertension. (PubMed id 22218754)1 Akhter Q....Ganai B.A. (Mol Med Rep 2012)
    584. Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training. (PubMed id 22975643)1 Walsh S....Pescatello L.S. (Gene 2012)
    585. Association between leptin and its soluble receptor with cardiometabolic risk factors in a Brazilian population. (PubMed id 22863437)1 Martins C.J....Francischetti E.A. (Eur. J. Intern. Med. 2012)
    586. Leptin locally synthesized in carotid atherosclerotic plaques could be associated with lesion instability and cerebral emboli. (PubMed id 23316287)1 Schneiderman J....Virmani R. (J Am Heart Assoc 2012)
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    588. Leptin and interferon-gamma as possible predictors of cesarean section among women with hypertensive disorders of pregnancy. (PubMed id 22847200)1 Rytlewski K....ReroA8 A. (Med. Sci. Monit. 2012)
    589. Relationship of insulin, glucose, leptin, IL-6 and TNF-I+ in human breast milk with infant growth and body composition. (PubMed id 22577092)1 Fields D.A. and Demerath E.W. (Pediatr Obes 2012)
    590. High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. (PubMed id 22463805)1 Saeed S....Froguel P. (Mol. Genet. Metab. 2012)
    591. Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells. (PubMed id 22087763)1 Zeddou M....Malaise M.G. (Stem Cells Dev. 2012)
    592. Association of genome variations in the renin-angiotensin system with physical performance. (PubMed id 23176367)1 Sgourou A....Papachatzopoulou A. (Hum. Genomics 2012)
    593. The unique cysteine knot regulates the pleotropic hormone leptin. (PubMed id 23029163)1 Haglund E....Onuchic J.N. (PLoS ONE 2012)
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    595. Study of the leptin levels and its gene polymorphisms in patients with idiopathic short stature and growth hormone deficiency. (PubMed id 22350661)1 Su P.H....Chen J.Y. (Endocrine 2012)
    596. Corticotropin-releasing hormone stimulates expression of leptin, 11beta-HSD2 and syncytin-1 in primary human trophoblasts. (PubMed id 22971074)1 Fahlbusch F.B....DAPtsch J. (amp 2012)
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    598. The association of leptin and C-reactive protein with the cardiovascular risk factors and metabolic syndrome score in Taiwanese adults. (PubMed id 22533665)1 Chiu F.H....Wang S.H. (Cardiovasc Diabetol 2012)
    599. Siglec-6 is expressed in gestational trophoblastic disease and affects proliferation, apoptosis and invasion. (PubMed id 23089140)1 Rumer K.K....Winn V.D. (Endocr. Relat. Cancer 2012)
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    601. The plasma leptin/adiponectin ratio predicts first cardiovascular event in men: a prospective nested case-control study. (PubMed id 22819464)1 Kappelle P.J....Wolffenbuttel B.H. (Eur. J. Intern. Med. 2012)
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    603. Regulation of leptin expression by 17beta-estradiol in human placental cells involves membrane associated estrogen receptor alpha. (PubMed id 22310000)1 Gambino Y.P....Varone C.L. (Biochim. Biophys. Acta 2012)
    604. Imatinib mesylate therapy induces reduction in neutrophil gelatinase-associated lipocalin serum levels and increase in leptin concentrations in chronic myeloid leukemia patients in molecular remission. (PubMed id 21986252)1 Alonci A....Musolino C. (Acta Haematol. 2012)
    605. Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: a cross-sectional study. (PubMed id 22035595)1 Mirza S....Fisher-Hoch S.P. (Cytokine 2012)
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    608. Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. (PubMed id 22595228)1 de Boer T.N....Mastbergen S.C. (Osteoarthr. Cartil. 2012)
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    612. Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer. (PubMed id 22193626)1 Farquharson A.J....Drew J.E. (Mol. Biol. Rep. 2012)
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    628. Association between the leptin gene 2548G/A polymorphism, the plasma leptin and the metabolic syndrome with psoriasis. (PubMed id 21569107)1 Abdel Hay R.M. and Rashed L.A. (Exp. Dermatol. 2011)
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    649. Hyperleptinaemia positively correlated with metabolic syndrome in hemodialysis patients. (PubMed id 22075293)1 Tsai J.P....Hsu B.G. (Eur. J. Intern. Med. 2011)
    650. Expression of leptin and leptin receptor isoforms in the rat and human carotid body. (PubMed id 21334312)1 Porzionato A....De Caro R. (Brain Res. 2011)
    651. [Expression of leptin and leptin receptor in hepatocellular carcinoma and the clinicopathological significance]. (PubMed id 21602135)1 Chen L....Dai G.H. (Nan Fang Yi Ke Da Xue Xue Bao 2011)
    652. [Effect of inhibition of cytosolic phospholipase Aa88 on Leptin release from human umbilical vein endothelial cells induced by lipopolysaccharide]. (PubMed id 21315000)1 Qi F. and Yan G.T. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2011)
    653. Soluble leptin receptor and leptin are associated with baseline adiposity and metabolic risk factors, and predict adiposity, metabolic syndrome, and glucose levels at 2-year follow-up: the Cyprus Metabolism Prospective Cohort Study. (PubMed id 21056886)1 Hamnvik O.P....Mantzoros C.S. (Metab. Clin. Exp. 2011)
    654. Serum leptin is associated with cardiometabolic risk and predicts metabolic syndrome in Taiwanese adults. (PubMed id 21526991)1 Li W.C....Wu K.H. (Cardiovasc Diabetol 2011)
    655. The interplay of YKL-40 and leptin in type 2 diabetic obese patients. (PubMed id 21715039)1 El-Mesallamy H.O....El Demerdash E. (Diabetes Res. Clin. Pract. 2011)
    656. Leptin expression and leptin receptor gene polymorphisms in growth hormone deficiency patients. (PubMed id 21207066)1 Su P.H....Yang S.F. (Hum. Genet. 2011)
    657. Association of cocaine- and amphetamine-related transcript, leptin and leptin receptor gene polymorphisms with anthropometric obesity phenotype indicators in South African learners. (PubMed id 21921635)1 Yako Y.Y....Matsha T.E. (J Nutrigenet Nutrigenomics 2011)
    658. Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts. (PubMed id 21562093)1 Ge Y.C....Sun K. (Reproduction 2011)
    659. Leptin is better than any other biological parameter for monitoring the efficacy of renutrition in hospitalized malnourished elderly patients. (PubMed id 21521316)1 Nivet-Antoine V....Bouillanne O. (Clin. Endocrinol. (Oxf) 2011)
    660. Effects of body fat on the associations of high-molecular-weight adiponectin, leptin and soluble leptin receptor with metabolic syndrome in Chinese. (PubMed id 21347230)1 Yu D....Lin X. (PLoS ONE 2011)
    661. Association of adiponectin and leptin with serum lipids and erythrocyte omega-3 and omega-6 fatty acids in dialysis patients. (PubMed id 21329629)1 An W.S....Vaziri N.D. (Clin. Nephrol. 2011)
    662. Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G &gt; A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia. (PubMed id 21631924)1 Skoczen S....Strojny W. (amp 2011)
    663. The polymorphism -2548G/A in leptin and severity of chronic obstructive pulmonary disease. (PubMed id 20854423)1 Ye X.W....Wen F.Q. (Int. J. Immunogenet. 2011)
    664. Adiponectin, AFABP, and leptin in human breast milk during 12 months of lactation. (PubMed id 21407103)1 Bronsky J....Nevoral J. (J. Pediatr. Gastroenterol. Nutr. 2011)
    665. [The role of promoter CpG islands methylation of leptin gene in osteoarthritis]. (PubMed id 21418891)1 Niu S.P....Yang T. (Zhonghua Nei Ke Za Zhi 2011)
    666. Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance. (PubMed id 21209035)1 Feuillan P.P....Biesecker L.G. (J. Clin. Endocrinol. Metab. 2011)
    667. Lack of association between LEP rs2167270 (19 G&gt;A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis. (PubMed id 21385539)1 GarcA-a-BermA_dez M....GonzA!lez-Gay M.A. (Clin. Exp. Rheumatol. 2011)
    668. Butyrate regulates leptin expression through different signaling pathways in adipocytes. (PubMed id 22122897)1 Soliman M.M....Abdel-Aal A.A. (J. Vet. Sci. 2011)
    669. Relationship between osteoporosis and adipose tissue leptin and osteoprotegerin in patients with chronic obstructive pulmonary disease. (PubMed id 21376149)1 Pobeha P....Tkacova R. (Bone 2011)
    670. Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia. (PubMed id 21906313)1 Molvarec A....RigA^ J. (amp 2011)
    671. Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. (PubMed id 21421855)1 Suzukawa M....Ohta K. (J. Immunol. 2011)
    672. Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: the Heart and Soul Study. (PubMed id 21176905)1 Ku I.A....Whooley M.A. (Atherosclerosis 2011)
    673. Influence of the metabolic syndrome on leptin and leptin receptor in breast cancer. (PubMed id 21574190)1 Carroll P.A....Connolly E.M. (Mol. Carcinog. 2011)
    674. Central leptin activates mitochondrial function and increases heat production in skeletal muscle. (PubMed id 21558317)1 Henry B.A....Clarke I.J. (Endocrinology 2011)
    675. Role of leptin and its receptors in the pathogenesis of thyroid cancer. (PubMed id 22076163)1 Uddin S....Al-Kuraya K.S. (Int J Clin Exp Pathol 2011)
    676. Effects of weight loss and leptin on skeletal muscle in human subjects. (PubMed id 21917907)1 Baldwin K.M....Rosenbaum M. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011)
    677. [Expression of HER-2 and leptin in gastric cancer and their clinical significance]. (PubMed id 22335909)1 Geng Y.T....Yin Y.M. (Zhonghua Zhong Liu Za Zhi 2011)
    678. The change of plasma ghrelin and leptin levels by the development of type 2 diabetes mellitus in patients with alcohol dependence. (PubMed id 21294754)1 Ju A....Kim D.J. (Alcohol. Clin. Exp. Res. 2011)
    679. Leptin reverts pro-apoptotic and antiproliferative effects of I+-linolenic acids in BCR-ABL positive leukemic cells: involvement of PI3K pathway. (PubMed id 21991326)1 Beaulieu A....Defresne M.P. (PLoS ONE 2011)
    680. Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter. (PubMed id 21931275)1 Marchi M....Maffei M. (Epigenetics 2011)
    681. Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth. (PubMed id 21173433)1 Choi J.H....Leung P.C. (Carcinogenesis 2011)
    682. Body mass index, leptin, and ambulatory blood pressure variability in healthy adults. (PubMed id 21146171)1 Abramson J.L....Murrah N.V. (Atherosclerosis 2011)
    683. Changes in serum leptin and adiponectin concentrations and insulin resistance after curative parathyroidectomy in moderate to severe primary hyperparathyroidism. (PubMed id 22159932)1 Bhadada S.K....Rao D.S. (Singapore Med J 2011)
    684. [Leptin and activity of tumor necrosis factor alpha relations with parameters of the trophologic status and digestion in patients with chronic obstructive pulmonary disease]. (PubMed id 21675251)1 (Ter. Arkh. 2011)
    685. Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis. (PubMed id 21228692)1 MA^rocz M....IllAcs T. (Spine 2011)
    686. Adiponectin/leptin ratio and metabolic syndrome in a Mexican American population. (PubMed id 21968271)1 Mirza S....Fisher-Hoch S.P. (Clin Invest Med 2011)
    687. A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. (PubMed id 21926355)1 Vanasse G.J....Berliner N. (Blood 2011)
    688. Common adipokine features of neonates and centenarians. (PubMed id 22308847)1 Meazza C....Bozzola M. (amp 2011)
    689. Sleep duration and biomarkers of metabolic function among police officers. (PubMed id 21785371)1 Charles L.E....Burchfiel C.M. (J. Occup. Environ. Med. 2011)
    690. The potential adverse role of leptin resistance in nonalcoholic fatty liver disease: a hypothesis based on critical review of the literature. (PubMed id 20717042)1 Polyzos S.A....Deretzi G. (J. Clin. Gastroenterol. 2011)
    691. Leptin, adiponectin and ghrelin, new potential mediators of ischemic stroke. (PubMed id 22167137)1 Kantorova E....Galajda P. (Neuro Endocrinol. Lett. 2011)
    692. Protein-energy wasting modifies the association of ghrelin with inflammation, leptin, and mortality in hemodialysis patients. (PubMed id 21178976)1 Carrero J.J....Stenvinkel P. (Kidney Int. 2011)
    693. Adipocytokines and CD34 progenitor cells in Alzheimer's disease. (PubMed id 21633502)1 Bigalke B....Laske C. (PLoS ONE 2011)
    694. Association between the chondrocyte phenotype and the expression of adipokines and their receptors: evidence for a role of leptin but not adiponectin in the expression of cartilage-specific markers. (PubMed id 21935928)1 Francin P.J....Presle N. (J. Cell. Physiol. 2011)
    695. Sexual dimorphism in the early life programming of serum leptin levels in European adolescents: the HELENA study. (PubMed id 21697251)1 Labayen I....Gottrand F. (J. Clin. Endocrinol. Metab. 2011)
    696. Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study. (PubMed id 21632080)1 Dalamaga M....Mantzoros C.S. (Metab. Clin. Exp. 2011)
    697. The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis. (PubMed id 21349112)1 Kaur S....Zilmer M. (J Eur Acad Dermatol Venereol 2011)
    698. Leptin deficiency and leptin gene mutations in obese children from Pakistan. (PubMed id 21854111)1 Fatima W....Mahmood S. (Int J Pediatr Obes 2011)
    699. Phenotypic and genetic variation in leptin as determinants of weight regain. (PubMed id 21042325)1 Erez G....Shai I. (Int J Obes (Lond) 2011)
    700. The peritoneal leptin, MCP-1 and TNF-I+ in the pathogenesis of endometriosis-associated infertility. (PubMed id 20825374)1 Tao Y....Luo W. (Am. J. Reprod. Immunol. 2011)
    701. Skeletal muscle insulin resistance in morbid obesity: the role of interleukin-6 and leptin. (PubMed id 21811961)1 Mitrou P....Dimitriadis G. (amp 2011)
    702. Insulin sensitivity in late gestation and early postpartum period: the role of circulating maternal adipokines. (PubMed id 21714696)1 Mazaki-Tovi S....Sivan E. (Gynecol. Endocrinol. 2011)
    703. Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet. (PubMed id 21465273)1 Cordero P....Martinez J.A. (J. Physiol. Biochem. 2011)
    704. Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients. (PubMed id 22020349)1 Kuo P.H....Huang M.C. (J Clin Psychopharmacol 2011)
    705. Polymorphisms in 5'-flanking regions of genes encoding adiponectin, leptin, and resistin are not associated with obesity of Polish children and adolescents. (PubMed id 20842437)1 Cieslak J....Switonski M. (Mol. Biol. Rep. 2011)
    706. Circulating leptin and inflammatory response in esophageal cancer, esophageal cancer-related cachexia-anorexia syndrome (CAS) and non-malignant CAS of the alimentary tract. (PubMed id 20541434)1 Diakowska D....Grabowski K. (Cytokine 2010)
    707. Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy. (PubMed id 20569445)1 Koda M....Sulkowski S. (BMC Cancer 2010)
    708. The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study. (PubMed id 20482813)1 Stannus O.P....Ding C. (amp 2010)
    709. Identification of the nasal mucosa as a new target for leptin action. (PubMed id 20546344)1 Taildeman J....PAcrez-Novo C.A. (Histopathology 2010)
    710. New frontiers in gut nutrient sensor research: nutrient sensors in the gastrointestinal tract: modulation of sweet taste sensitivity by leptin. (PubMed id 20093782)1 Horio N....Ninomiya Y. (J. Pharmacol. Sci. 2010)
    711. Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy. (PubMed id 20724651)1 Bouchard L....Brisson D. (Diabetes Care 2010)
    712. The neuroendocrine basis of lactation-induced suppression of GnRH: role of kisspeptin and leptin. (PubMed id 20727862)1 Smith M.S....Grove K.L. (Brain Res. 2010)
    713. Clustering of leptin and physical activity with components of metabolic syndrome in Iranian population: an exploratory factor analysis. (PubMed id 21046482)1 Esteghamati A....Gouya M.M. (Endocrine 2010)
    714. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    715. Psychobiology of purging disorder: reduction in circulating leptin levels in purging disorder in comparison with controls. (PubMed id 19722179)1 Jimerson D.C....Keel P.K. (Int J Eat Disord 2010)
    716. Selected adipokines - plasma concentrations and adipose tissue expressions during 24-hour lipid infusion in healthy men. (PubMed id 19249901)1 KopeckA1 J....PelikA!novA! T. (Physiol Res 2010)
    717. Association of ghrelin and leptin with reproductive hormones in constitutional delay of growth and puberty. (PubMed id 21176234)1 El-Eshmawy M.M....El Hawary A.K. (amp 2010)
    718. The effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages. (PubMed id 20713036)1 Taneli F....Taneli C. (Clin. Biochem. 2010)
    719. Increased tissue leptin hormone level and mast cell count in skin tags: a possible role of adipoimmune in the growth of benign skin growths. (PubMed id 20826994)1 El Safoury O....Rashed L. (Indian J Dermatol Venereol Leprol 2010)
    720. Adipokines in patients with cancer anorexia and cachexia. (PubMed id 20215915)1 Smiechowska J....Garcia J.M. (J. Investig. Med. 2010)
    721. Adiponectin-leptin ratio: a useful estimate of insulin resistance in patients with Type 2 diabetes. (PubMed id 20142631)1 Zaletel J....Prezelj J. (J. Endocrinol. Invest. 2010)
    722. Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatment. (PubMed id 21105276)4 Perez-Iglesias R....Crespo-Facorro B. (J Clin Psychopharmacol 2010)
    723. Adipocytokines in subjects with and without ischemic cerebrovascular disease. (PubMed id 21114131)1 Jaleel A....Jaleel F. (Acta Neurol Belg 2010)
    724. Leptin, soluble leptin receptors, free leptin index, and their relationship with insulin resistance and BMI: high normal BMI is the threshold for serum leptin increase in humans. (PubMed id 20455195)1 Owecki M....SowiA8ski J. (Horm. Metab. Res. 2010)
    725. The modulating effect of the androgen receptor on craving in alcohol withdrawal of men is partially mediated by leptin. (PubMed id 19884906)1 Lenz B....Hillemacher T. (Pharmacogenomics J. 2010)
    726. Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways. (PubMed id 20484458)1 MaymA^ J.L....Varone C.L. (Endocrinology 2010)
    727. Correlation between leptin level and hypertension in normal and obese pre- and postmenopausal women. (PubMed id 20841449)1 Khokhar K.K....Kaur G. (Eur. J. Endocrinol. 2010)
    728. Serum leptin and adiponectin levels correlate with severity of allergic rhinitis. (PubMed id 19725899)1 Hsueh K.C....Lin C.Y. (Pediatr Allergy Immunol 2010)
    729. Relationships between contraction properties of knee extensor muscles and fasting IGF-1 and adipocytokines in physically active postmenopausal women. (PubMed id 20633033)1 JA1rimAoe T....JA1rimAoe J. (Clin Physiol Funct Imaging 2010)
    730. Leptin on peritoneal macrophages of patients with endometriosis. (PubMed id 20047585)1 Wu M.H....Tsai S.J. (Am. J. Reprod. Immunol. 2010)
    731. 17Beta-estradiol enhances leptin expression in human placental cells through genomic and nongenomic actions. (PubMed id 20237333)1 Gambino Y.P....Varone C.L. (Biol. Reprod. 2010)
    732. Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. (PubMed id 20395593)1 Saleem U....Kullo I.J. (Arterioscler. Thromb. Vasc. Biol. 2010)
    733. Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. (PubMed id 20220015)1 Tolson K.P....Kublaoui B.M. (J. Neurosci. 2010)
    734. Combined HTR2C-LEP genotype as a determinant of obesity in patients using antipsychotic medication. (PubMed id 21105285)4 Gregoor J.G....van der Weide J. (J Clin Psychopharmacol 2010)
    735. Serum leptin concentrations during the menstrual cycle in Iranian healthy women. (PubMed id 21287461)1 Einollahi N....Nabatchian F. (Acta Med Iran 2010)
    736. Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells. (PubMed id 20589829)1 Naviglio S....Spina A. (J. Cell. Physiol. 2010)
    737. Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training. (PubMed id 20517895)1 Huuskonen A....Atalay M. (Cell Biochem. Funct. 2010)
    738. Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study. (PubMed id 19959759)1 Sun Q....Hu F.B. (Diabetes 2010)
    739. Leptin regulates AMPA receptor trafficking via PTEN inhibition. (PubMed id 20237279)1 Moult P.R....Harvey J. (J. Neurosci. 2010)
    740. Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients. (PubMed id 21263187)1 Partida-PAcrez M....GutiAcrrez-Angulo M. (Cancer Biomark 2010)
    741. Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin. (PubMed id 20372853)1 Kim J.Y....Lee Y.Y. (Oncol. Rep. 2010)
    742. Fasting serum leptin level correlates with mid-arm fat area in peritoneal dialysis patients. (PubMed id 21118367)1 Fang T.C....Hsu B.G. (Ther Apher Dial 2010)
    743. Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. (PubMed id 20413520)1 Mente A.... . (Diabetes Care 2010)
    744. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. (PubMed id 21123564)1 Koch C....Tups A. (J. Neurosci. 2010)
    745. Serum leptin: a marker of prostate cancer irrespective of obesity. (PubMed id 21045260)1 Singh S.K....Jha V. (Cancer Biomark 2010)
    746. Polymorphisms of the LEP- and LEPR genes, metabolic profile after prolonged clozapine administration and response to the antidiabetic metformin. (PubMed id 20591628)1 FernA!ndez E....Baptista T. (Schizophr. Res. 2010)
    747. Insulin resistance, serum leptin, and adiponectin levels and outcomes of viral hepatitis C cirrhosis. (PubMed id 20728234)1 Nkontchou G....Beaugrand M. (J. Hepatol. 2010)
    748. Sex steroids, growth hormone, leptin and the pubertal growth spurt. (PubMed id 19955758)1 Rogol A.D. (Endocr Dev 2010)
    749. Associations of polymorphisms in adiponectin and leptin genes with men's longevity. (PubMed id 20201642)1 Khabour O.F....Alzoubi K.H. (Aging Male 2010)
    750. Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway. (PubMed id 20497020)1 Woo H.J....Kim Y.D. (Exp. Lung Res. 2010)
    751. [The relationship of leptin and adiponectin with insulin resistance in nonalcoholic fatty liver disease]. (PubMed id 20587319)1 Li Y.L....Wang B.Y. (Zhonghua Gan Zang Bing Za Zhi 2010)
    752. Leptin and ghrelin in Korean systemic lupus erythematosus. (PubMed id 19965946)1 Kim H.A....Suh C.H. (Lupus 2010)
    753. Associations between serum leptin level and bone turnover in kidney transplant recipients. (PubMed id 20688883)1 Kovesdy C.P....Mucsi I. (Clin J Am Soc Nephrol 2010)
    754. Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity. (PubMed id 19910644)1 Heida N.M....SchAofer K. (Arterioscler. Thromb. Vasc. Biol. 2010)
    755. Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells. (PubMed id 20171193)1 Ren H....Hao J. (Biochem. Biophys. Res. Commun. 2010)
    756. Leptin exacerbates sepsis-mediated morbidity and mortality. (PubMed id 20519646)1 Shapiro N.I....Yano K. (J. Immunol. 2010)
    757. MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells. (PubMed id 20465992)1 PAcrez-PAcrez A....SA!nchez-Margalet V. (Biochem. Biophys. Res. Commun. 2010)
    758. Association between LEP and LEPR gene polymorphisms and dyslipidemia in patients using atypical antipsychotic medication. (PubMed id 20562674)1 Gregoor J.G....Heerdink E.R. (Psychiatr. Genet. 2010)
    759. Leptin is associated with the size of the apolipoprotein(a) particle in African tribal populations living on fish or vegetarian diet. (PubMed id 20197188)1 Winnicki M....Pauletto P. (Atherosclerosis 2010)
    760. Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma. (PubMed id 20008098)1 Uddin S....Al-Kuraya K.S. (Endocr. Relat. Cancer 2010)
    761. Serum levels of adipokines resistin and leptin in patients with colon cancer. (PubMed id 21254741)1 SA8lA8geanu A....Neagu S. (J Med Life 2010)
    762. Promotion of melanoma growth by the metabolic hormone leptin. (PubMed id 20204272)1 Ellerhorst J.A....Grimm E.A. (Oncol. Rep. 2010)
    763. Relationship between leptin, adiponectin, bone mineral density, and measures of adiposity among pre-menopausal Hispanic and Caucasian women. (PubMed id 20712424)1 King G.A....Thompson D.L. (Endocr. Res. 2010)
    764. NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. (PubMed id 20097762)1 Jang P.G....Kim M.S. (J. Biol. Chem. 2010)
    765. A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. (PubMed id 20382689)1 Fischer-Posovszky P....Wabitsch M. (J. Clin. Endocrinol. Metab. 2010)
    766. Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue. (PubMed id 19376162)1 Nielsen N.B....Stallknecht B. (Regul. Pept. 2009)
    767. Leptin concentrations are a predictor of overweight reduction in a lifestyle intervention. (PubMed id 19922035)1 Reinehr T....Andler W. (Int J Pediatr Obes 2009)
    768. [Human genetic mutations and polymorphisms of adipocytokines relating to obesity]. (PubMed id 19202898)1 Hiuge A. and Kihara S. (Nippon Rinsho 2009)
    769. The ambiguous role of the Na+-H+ exchanger isoform 1 (NHE1) in leptin-induced oxidative stress in human monocytes. (PubMed id 19301149)1 Konstantinidis D....Kaloyianni M. (amp 2009)
    770. Adipokines in a group of Mexican patients with nonalcoholic steatohepatitis. (PubMed id 19502655)1 MuA+oz L.E....Segura J.J. (Ann Hepatol 2009)
    771. Effects of exercise on energy-regulating hormones and appetite in men and women. (PubMed id 19073905)1 Hagobian T.A....Braun B. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009)
    772. Effects of adiponectin and leptin co-treatment on human breast cancer cell growth. (PubMed id 19424644)1 Nkhata K.J....Cleary M.P. (Oncol. Rep. 2009)
    773. Relation of serum leptin to blood pressure of Japanese in Japan and Japanese-Americans in Hawaii. (PubMed id 19841291)1 Nakamura Y....Stamler J. (Hypertension 2009)
    774. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. (PubMed id 19656776)1 Tobi E.W....Heijmans B.T. (Hum. Mol. Genet. 2009)
    775. Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO. (PubMed id 19793853)4 den Hoed M....Westerterp K.R. (Am. J. Clin. Nutr. 2009)
    776. The relationship between leptin, gonadotropic hormones, and body composition during puberty in a Dutch children cohort. (PubMed id 19332528)1 Rutters F....Westerterp-Plantenga M.S. (Eur. J. Endocrinol. 2009)
    777. Longitudinal analysis of leptin variation during weight regain after weight loss in obese children. (PubMed id 20054230)1 Holm J.C....Heitmann B.L. (Obes Facts 2009)
    778. Serum and synovial fluid leptin levels and markers of inflammation in rheumatoid arthritis. (PubMed id 19009296)1 Seven A....Hamuryudan V. (Rheumatol. Int. 2009)
    779. Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin. (PubMed id 19589139)1 Langouche L....Van den Berghe G. (Crit Care 2009)
    780. PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling. (PubMed id 19940178)1 Hawke Z....Luckman S.M. (J. Neurosci. 2009)
    781. Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation. (PubMed id 18988190)1 Catalano S....AndA^ S. (J. Cell. Physiol. 2009)
    782. Adipocytokines are associated with renal function in patients with normal range glomerular filtration rate and type 2 diabetes. (PubMed id 19223200)1 Barlovic D.P....Prezelj J. (Cytokine 2009)
    783. Elevated serum leptin levels: a risk factor for non-small-cell lung cancer? (PubMed id 19033693)1 Terzidis A....Petridou E.T. (Oncology 2009)
    784. Gene expression of placental hormones regulating energy balance in small for gestational age neonates. (PubMed id 19004538)1 Struwe E....DAPtsch J. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2009)
    785. Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study. (PubMed id 19141993)1 Hung C.Y....Peng S.J. (Blood Purif. 2009)
    786. Serum leptin level and cognition in the elderly: Findings from the Health ABC Study. (PubMed id 18358569)1 Holden K.F....Yaffe K. (Neurobiol. Aging 2009)
    787. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    788. Signaling components involved in leptin-induced amplification of the atherosclerosis-related properties of human monocytes. (PubMed id 18843191)1 Konstantinidis D....Kaloyianni M. (J. Vasc. Res. 2009)
    789. Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents. (PubMed id 19466592)1 do Prado W.L....DAcmaso A.R. (J. Bone Miner. Metab. 2009)
    790. Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells. (PubMed id 19112600)1 McMurtry V....Tari A.M. (amp 2009)
    791. A marker of growth differs between adolescents with high vs. low sugar preference. (PubMed id 19150454)1 Coldwell S.E....Reed D.R. (amp 2009)
    792. Serum leptin levels and irritable bowel syndrome: a new hypothesis. (PubMed id 19398923)1 Semnani S....Joshaghani H. (J. Clin. Gastroenterol. 2009)
    793. Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels. (PubMed id 19576209)1 Yan G.T....Wang L.H. (Eur. J. Pharmacol. 2009)
    794. Serum adipocytokine levels in prostate cancer patients. (PubMed id 19322011)1 Arisan E.D....Ergenekon E. (Urol. Int. 2009)
    795. Osteoporosis: a neuroskeletal disease? (PubMed id 18761104)1 Takeda S. (amp 2009)
    796. Does an altered leptin axis play a role in obesity among children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency? (PubMed id 19004982)1 VAPlkl T.M....DAPrr H.G. (Eur. J. Endocrinol. 2009)
    797. Leptin, insulin, and obesity-related phenotypes: genetic influences on levels and longitudinal changes. (PubMed id 19214176)1 Friedlander Y....Miserez A.R. (Obesity (Silver Spring) 2009)
    798. Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function. (PubMed id 19751193)1 Dozio E....Magni P. (amp 2009)
    799. Anthropometric and leptin changes in women following different dietary approaches to weight loss. (PubMed id 18997680)1 Miller L.E....Nickols-Richardson S.M. (Obesity (Silver Spring) 2009)
    800. Leptin induces migration and invasion of glioma cells through MMP-13 production. (PubMed id 18814267)1 Yeh W.L....Fu W.M. (Glia 2009)
    801. Serum leptin levels during pregnancy in multiple sclerosis. (PubMed id 19667019)1 Neuteboom R.F....Hintzen R.Q. (Mult. Scler. 2009)
    802. Sam68 and ERKs regulate leptin-induced expression of OB-Rb mRNA in C2C12 myotubes. (PubMed id 19524014)1 Maroni P....Bendinelli P. (Mol. Cell. Endocrinol. 2009)
    803. Leptin does not mediate short-term fasting-induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states. (PubMed id 18445667)1 Chan J.L....Mantzoros C.S. (J. Clin. Endocrinol. Metab. 2008)
    804. Leptin enhances human beta-defensin-2 production in human keratinocytes. (PubMed id 18556347)1 Kanda N. and Watanabe S. (Endocrinology 2008)
    805. Serum leptin and its relationship with metabolic variables in Arabs with type 2 diabetes mellitus. (PubMed id 18779635)1 Al-Shoumer K.A....Vasanthy B.A. (Ann Saudi Med 2008)
    806. The influence of ghrelin, adiponectin, and leptin on bone mineral density in healthy postmenopausal women. (PubMed id 18979162)1 JA1rimAoe J....Kums T. (J. Bone Miner. Metab. 2008)
    807. Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma. (PubMed id 18573568)1 Ribatti D....Vacca A. (Peptides 2008)
    808. Leptin, blood pressure, and aerobic capacity in women. (PubMed id 18756258)1 Sabatier M.J....Cannon J.G. (Am. J. Hypertens. 2008)
    809. Change in adipocytokines and ghrelin with menopause. (PubMed id 18280066)1 Sowers M.R....Jannausch M.L. (Maturitas 2008)
    810. [A new mutation c.422C&gt;G (p.S141C) in homo- and heterozygous forms of the human leptin gene]. (PubMed id 19088762)1 Chekhranova M.K....Pankov I.u.A. (Bioorg. Khim. 2008)
    811. Low leptin levels in migraine: a case control study. (PubMed id 18547265)1 Guldiken B....Tugrul A. (Headache 2008)
    812. Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia. (PubMed id 18515891)1 Yevtushenko O.O....Reynolds G.P. (Br J Psychiatry 2008)
    813. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? (PubMed id 17347881)1 Ashwood P....Van de Water J. (J Autism Dev Disord 2008)
    814. Psoriasis independently associated with hyperleptinemia contributing to metabolic syndrome. (PubMed id 19075139)1 Chen Y.J....Chen C.M. (Arch Dermatol 2008)
    815. Seven placental transcripts characterize HELLP-syndrome. (PubMed id 18374411)1 Buimer M....Ris-Stalpers C. (Placenta 2008)
    816. Plasma and synovial fluid adipocytokines in patients with rheumatoid arthritis and osteoarthritis. (PubMed id 20306680)1 Ibrahim S.M....Amer N. (Egypt J Immunol 2008)
    817. Centrally located body fat is related to appetitive hormones in healthy postmenopausal women. (PubMed id 18390991)1 Ritland L.M....Genschel U. (Eur. J. Endocrinol. 2008)
    818. Leptin and regulation of linear growth. (PubMed id 18403928)1 Gat-Yablonski G. and Phillip M. (Curr Opin Clin Nutr Metab Care 2008)
    819. Hyperleptinemia is associated with hypertension in Japanese males. (PubMed id 18596833)1 Imatoh T....Doi H. (Acta Med. Okayama 2008)
    820. Sympathetic overactivity and plasma leptin levels in Rett syndrome. (PubMed id 18226448)1 Acampa M....Auteri A. (Neurosci. Lett. 2008)
    821. AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity. (PubMed id 18255222)1 JanovskA! A....Wittert G.A. (Mol. Cell. Endocrinol. 2008)
    822. Contribution of leptin receptor N-linked glycans to leptin binding. (PubMed id 17983356)1 Kamikubo Y....Ruggeri Z.M. (Biochem. J. 2008)
    823. Leptin expression in Peripheral Blood Mononuclear Cells (PBMCs) is related with blood pressure variability. (PubMed id 18501706)1 Samara A....Visvikis-Siest S. ( international journal of clinical chemistry 2008)
    824. cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin. (PubMed id 18253488)1 Yang D.C....Hung S.C. (PLoS ONE 2008)
    825. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. (PubMed id 18568078)1 Rosenbaum M....Hirsch J. (J. Clin. Invest. 2008)
    826. Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes. (PubMed id 18463145)1 Wang B....Trayhurn P. (J. Endocrinol. 2008)
    827. Insulin resistance, physical fitness, body composition and leptin concentration in 7-8 year-old children. (PubMed id 17215165)1 Slinger J.D....Kuipers H. (J Sci Med Sport 2008)
    828. Screening of hypoxia-inducible genes in sporadic ALS. (PubMed id 18608101)4 Cronin S....Hardiman O. (Amyotroph Lateral Scler 2008)
    829. Negative effect of leptin on bone mass in type 1 diabetes. (PubMed id 18690407)1 Kassem H.S....Azar S.T. (Acta Diabetol 2008)
    830. Leptin as a neuroprotective agent. (PubMed id 18222172)1 Tang B.L. (Biochem. Biophys. Res. Commun. 2008)
    831. Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels. (PubMed id 18633111)1 Nakamura Y....Ninomiya Y. (Diabetes 2008)
    832. The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis? (PubMed id 18552206)1 Matarese G....De Rosa V. (J. Leukoc. Biol. 2008)
    833. Influence of Lys656Asn polymorphism of the leptin receptor gene on insulin resistance in nondiabetic obese patients. (PubMed id 18413223)1 de Luis D.A....Conde R. (J. Diabetes Complicat. 2008)
    834. Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha. (PubMed id 17653093)1 Cascio S....Surmacz E. (Oncogene 2008)
    835. Polysomnographic sleep, growth hormone insulin-like growth factor-I axis, leptin, and weight loss. (PubMed id 18464752)1 Rasmussen M.H....Hilsted J. (Obesity (Silver Spring) 2008)
    836. Leptin affects proliferation-, apoptosis- and protein kinase A-related peptides in human ovarian granulosa cells. (PubMed id 17465693)1 Sirotkin A.V....HetAcnyi L. (Physiol Res 2008)
    837. Gender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity. (PubMed id 18941624)1 Guerra B....Calbet J.A. (PLoS ONE 2008)
    838. Increased serum levels of leptin in retinal vein occlusion. (PubMed id 18679012)1 Ates O....Baykal O. (Tohoku J. Exp. Med. 2008)
    839. Low leptin but high insulin resistance of smokers in Japanese men. (PubMed id 18579252)1 Hotta Y....Tamakoshi K. (Diabetes Res. Clin. Pract. 2008)
    840. Leptin replacement improves cognitive development. (PubMed id 18769731)1 Paz-Filho G.J....Licinio J. (PLoS ONE 2008)
    841. Relationships between finger-length ratios, ghrelin, leptin, IGF axis, and sex steroids in young male and female swimmers. (PubMed id 18584199)1 JA1rimAoe T....Purge P. (Eur. J. Appl. Physiol. 2008)
    842. Atherogenecity of LDL and unfavorable adipokine profile in metabolically obese, normal-weight woman. (PubMed id 18239579)1 Hyun Y.J....Lee J.H. (Obesity (Silver Spring) 2008)
    843. Serum leptin in systemic lupus erythematosus. (PubMed id 18196243)1 WisA8owska M....Kuklo-Kowalska A. (Rheumatol. Int. 2008)
    844. Panel of markers can accurately predict endometriosis in a subset of patients. (PubMed id 17706208)1 Seeber B....Barnhart K.T. (Fertil. Steril. 2008)
    845. Polymorphism within the intron region of the bovine leptin gene in Iranian Sarabi cattle (Iranian Bos taurus). (PubMed id 18666562)1 Javanmard A....Asadzadeh N. (Genetika 2008)
    846. Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion. (PubMed id 18658052)1 Schroeter M.R....SchAofer K. (Circ. Res. 2008)
    847. Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. (PubMed id 18978578)1 Zhao C.Q....Dai L.Y. (Spine 2008)
    848. Central nervous system regulation of energy metabolism: ghrelin versus leptin. (PubMed id 18448790)1 Nogueiras R....Zigman J.M. (Ann. N. Y. Acad. Sci. 2008)
    849. Concomitant activation of the JAK/STAT3 and ERK1/2 signaling is involved in leptin-mediated proliferation of renal cell carcinoma Caki-2 cells. (PubMed id 18787400)1 Li L....He D.L. (amp 2008)
    850. Serum adiponectin and leptin concentrations in patients with chronic pancreatitis of alcoholic and nonalcoholic origin. (PubMed id 18376301)1 Adrych K....Swierczynski J. (Pancreas 2008)
    851. Serum leptin level in acute myeloid leukemia patients. (PubMed id 18534061)1 Yilmaz M....Tarakcioglu M. (Hematology 2008)
    852. Leptin regulates the proliferation and apoptosis of human endometrial epithelial cells. (PubMed id 18949391)1 Tanaka T. and Umesaki N. (Int. J. Mol. Med. 2008)
    853. [Role of adipocytokine in bone metabolism]. (PubMed id 18445880)1 Ebina K....Shimomura I. (Clin Calcium 2008)
    854. Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin Study. (PubMed id 18299466)1 Lappalainen T....Gylling H. (Eur. J. Endocrinol. 2008)
    855. Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women. (PubMed id 18604373)1 Hinuy H.M....Hirata R.D. (Arq Bras Endocrinol Metabol 2008)
    856. Investigation for the leptin 1 and LEP G2548A gene polymorphism in psoriasis. (PubMed id 18474470)1 Senturk N....Turanli A.Y. (Eur J Dermatol 2008)
    857. Balance of adiponectin and leptin modulates breast cancer cell growth. (PubMed id 18957939)1 Grossmann M.E....Cleary M.P. (Cell Res. 2008)
    858. Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence. (PubMed id 17535427)1 Noer A....Collas P. (BMC Cell Biol. 2007)
    859. [Leptin, leptin gene, leptin gene receptor polymorphisms and pregnancy]. (PubMed id 18050615)1 Iciek R....Brazert J. (Ginekol. Pol. 2007)
    860. Plasma ghrelin is altered after maximal exercise in elite male rowers. (PubMed id 17609506)1 JA1rimAoe J....Purge P. (Exp. Biol. Med. (Maywood) 2007)
    861. Serum leptin correlates in infertile oligozoospermic males. (PubMed id 17714215)1 Hanafy S....Khalil K.T. (Andrologia 2007)
    862. Peripheral leptin levels in narcoleptic patients. (PubMed id 17705690)1 Dahmen N....Tonn P. (amp 2007)
    863. Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study. (PubMed id 17967974)1 Golledge J....Norman P.E. (Circulation 2007)
    864. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    865. Elevated plasma adiponectin and leptin levels in sisters with genetically defective insulin receptors. (PubMed id 17965293)1 Hattori Y....Kasai K. (Diabetes Care 2007)
    866. Serum acylated ghrelin, adiponectin and leptin levels in normal-weight and obese premenopausal women. (PubMed id 17992641)1 Krzyzanowska-Swiniarska B....Pilarska K. (Horm. Metab. Res. 2007)
    867. Leptin predicts the development of diabetes in Mauritian men, but not women: a population-based study. (PubMed id 17325688)1 SAPderberg S....Shaw J.E. (Int J Obes (Lond) 2007)
    868. Innate immunity modulates adipokines in humans. (PubMed id 17374708)1 Anderson P.D....Reilly M.P. (J. Clin. Endocrinol. Metab. 2007)
    869. Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. (PubMed id 16580675)1 Zhang Y.Y....Doria A. (Atherosclerosis 2007)
    870. Leptin serum levels in the first year post-renal transplantation. (PubMed id 17362752)1 Souza G.C....Manfro R.C. (Transplant. Proc. 2007)
    871. Body Mass Index, percent body fat, and regional body fat distribution in relation to leptin concentrations in healthy, non-smoking postmenopausal women in a feeding study. (PubMed id 17229323)1 Mahabir S....Taylor P.R. (Nutr J 2007)
    872. Sex differences in the association between leptin and CRP: results from the Dallas Heart Study. (PubMed id 17141244)1 Abdullah Lemos J.A. (Atherosclerosis 2007)
    873. Time course and determinants of leptin decline during weight loss in obese boys and girls. (PubMed id 17763005)1 Holm J.C....rensen T.I. (Int J Pediatr Obes 2007)
    874. Leptin regulates striatal regions and human eating behavior. (PubMed id 17690262)1 Farooqi I.S....Fletcher P.C. (Science 2007)
    875. The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle. (PubMed id 17333366)1 Hill M.J....Frattarelli J.L. (J. Assist. Reprod. Genet. 2007)
    876. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. (PubMed id 17344214)1 Saxena N.K....Sharma D. (J. Biol. Chem. 2007)
    877. Relationship between blood adipocytokines and resting energy expenditure in young and elderly women. (PubMed id 18202542)1 Usui C....Higuchi M. (J. Nutr. Sci. Vitaminol. 2007)
    878. Serum leptin levels in patients with ocular and nonocular BehAset's disease. (PubMed id 17641728)1 YalAsindaA9 F.N....CaA9layan O. (Mediators Inflamm. 2007)
    879. Influence of BMI and gender on postprandial hormone responses. (PubMed id 18198306)1 Carroll J.F....Caffrey J.L. (Obesity (Silver Spring) 2007)
    880. Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations. (PubMed id 17957153)1 James R.J....Cheetham T.D. (Pediatr. Res. 2007)
    881. Low CSF leptin levels are associated with worse learning and memory performance in HIV-infected men. (PubMed id 18040853)1 Huang J.S....Ellis R. (J Neuroimmune Pharmacol 2007)
    882. Serum leptin levels correlate with interleukin-6 levels and disease activity in patients with ankylosing spondylitis. (PubMed id 17476615)1 Park M.C....Lee S.K. (Scand. J. Rheumatol. 2007)
    883. Leptin signalling and leptin-mediated activation of human platelets: importance of JAK2 and the phospholipases Cgamma2 and A2. (PubMed id 18000612)1 Dellas C....Konstantinides S.V. (Thromb. Haemost. 2007)
    884. Leptin and its correlation with exocrine and endocrine pancreatic function in idiopathic chronic pancreatitis: implications for pathophysiology. (PubMed id 17895848)1 Midha S....Garg P.K. (Pancreas 2007)
    885. Increased insulin sensitivity in patients with anorexia nervosa: the role of adipocytokines. (PubMed id 17184143)1 DostA!lovA! I....NedvA-dkovA! J. (Physiol Res 2007)
    886. Roles of leptin in prenatal and perinatal brain development. (PubMed id 17688465)1 Udagawa J....Otani H. (Congenit Anom (Kyoto) 2007)
    887. Oxidative status and serum leptin levels in obese prepubertal children. (PubMed id 16874844)1 Ustundag B....Yilmaz E. (Cell Biochem. Funct. 2007)
    888. Leptin in embryos from control and diabetic rats during organogenesis: a modulator of nitric oxide production and lipid homeostasis. (PubMed id 17506117)1 White V....Jawerbaum A. (Diabetes Metab. Res. Rev. 2007)
    889. Plasma leptin levels and coronary artery calcification in older adults. (PubMed id 17148566)1 Iribarren C....Fortmann S.P. (J. Clin. Endocrinol. Metab. 2007)
    890. Expression of leptin, leptin receptor, and hypoxia-inducible factor 1 alpha in human endometrial cancer. (PubMed id 17404022)1 Koda M....Sulkowski S. (Ann. N. Y. Acad. Sci. 2007)
    891. Leptin induces C-reactive protein expression in vascular endothelial cells. (PubMed id 17615382)1 Singh P....Somers V.K. (Arterioscler. Thromb. Vasc. Biol. 2007)
    892. The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer. (PubMed id 18004080)1 Liu C.L....Chen C.P. (Oncology 2007)
    893. Childhood obesity and its relation to serum adiponectin and leptin: a report from a population-based study. (PubMed id 17118479)1 Nishimura R....Tajima N. (Diabetes Res. Clin. Pract. 2007)
    894. Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. (PubMed id 17350295)1 Simopoulou T....Tsezou A. (Osteoarthr. Cartil. 2007)
    895. Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis. (PubMed id 17617917)1 Al-Daghri N.M....Kumar S. (Cardiovasc Diabetol 2007)
    896. Leptin directly controls proliferation, apoptosis and secretory activity of cultured chicken ovarian cells. (PubMed id 17604668)1 Sirotkin A.V. and Grossmann R. (amp 2007)
    897. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. (PubMed id 17726024)1 Gong Y....Myers M.G. (J. Biol. Chem. 2007)
    898. Reduced brain leptin in patients with major depressive disorder and in suicide victims. (PubMed id 16936761)1 Eikelis N....Lambert G. (Mol. Psychiatry 2006)
    899. Intra-follicular leptin concentration as a predictive factor for in vitro oocyte fertilization in assisted reproductive techniques. (PubMed id 17033261)1 De Placido G....Matarese G. (J. Endocrinol. Invest. 2006)
    900. Changes in placental adipocytokine gene expression associated with gestational diabetes mellitus. (PubMed id 16343040)1 Meller M....Williams M.A. (Physiol Res 2006)
    901. Association of serum leptin with anemia in maintenance hemodialysis patients. (PubMed id 17186687)1 Nasri H. (Saudi J Kidney Dis Transpl 2006)
    902. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. (PubMed id 16804073)1 Biddinger S.B....Kahn C.R. (Diabetes 2006)
    903. Serum leptin is not a diagnostic marker for familial Mediterranean fever attacks. (PubMed id 16883064)1 Toy B....TiftikAsi A. (Mediators Inflamm. 2006)
    904. Loss of resistin improves glucose homeostasis in leptin deficiency. (PubMed id 17065346)1 Qi Y....Ahima R.S. (Diabetes 2006)
    905. Perceived psychological stress and serum leptin concentrations in Japanese men. (PubMed id 17062814)1 Otsuka R....Toyoshima H. (Obesity (Silver Spring) 2006)
    906. A physiological role of breast milk leptin in body weight control in developing infants. (PubMed id 16988079)1 Miralles O....PicA^ C. (Obesity (Silver Spring) 2006)
    907. Insulinemia and leptinemia in geriatric patients: markers of the metabolic syndrome or of undernutrition? (PubMed id 16799400)1 Bonin-Guillaume S....Vischer U.M. (amp 2006)
    908. Genetics of obesity in humans. (PubMed id 17122358)1 Farooqi S. and O'Rahilly S. (Endocr. Rev. 2006)
    909. Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women. (PubMed id 16705078)1 Kok P....Pijl H. (J. Clin. Endocrinol. Metab. 2006)
    910. [Relationship between leptin gene of adipose tissues and nonalcoholic fatty liver disease]. (PubMed id 17125610)1 Yang H....Sha W.H. (Zhonghua Gan Zang Bing Za Zhi 2006)
    911. Leptin and adiponectin levels in acute pancreatitis. (PubMed id 16552343)1 Tukiainen E....Repo H. (Pancreas 2006)
    912. Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers. (PubMed id 16609020)1 RAcvillion F....Peyrat J.P. (Clin. Cancer Res. 2006)
    913. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. (PubMed id 16582918)1 Chen K....Zhao A.Z. (Nat. Med. 2006)
    914. Hyperleptinemia is not responsible for decreased paraoxonase activity in hemodialysis patients. (PubMed id 16534235)1 Varga Z....Bajnok L. (Nephron Clin Pract 2006)
    915. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    916. Prolonged fasting in patients with chronic pain syndromes leads to late mood-enhancement not related to weight loss and fasting-induced leptin depletion. (PubMed id 17263085)1 Michalsen A....Dobos G.J. (Nutr Neurosci 2006)
    917. Leptin enhances in vitro secretion of IgG antiplatelet antibodies by splenocytes and peripheral blood mononuclear cells from patients with chronic idiopathic thrombocytopenic purpura. (PubMed id 16774845)1 Ren H....Han Z.C. (Clin. Immunol. 2006)
    918. Variation in expression of gastric leptin according to differentiation and growth pattern in gastric adenocarcinoma. (PubMed id 16434209)1 Hong S.J....Kim B.S. (Cytokine 2006)
    919. The Gln223Arg polymorphism of the leptin receptor gene and peripheral blood/bone marrow leptin level in leukemic children. (PubMed id 17072067)1 Wasik M....Demkow U. (J. Physiol. Pharmacol. 2006)
    920. In vivo methylation patterns of the leptin promoter in human and mouse. (PubMed id 17965621)1 StAPger R. (Epigenetics 2006)
    921. Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. (PubMed id 15882975)1 Pai R....Tarnawski A. (Biochem. Biophys. Res. Commun. 2005)
    922. Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. (PubMed id 16009333)1 Caldefie-ChAczet F....Vasson M.P. (Biochem. Biophys. Res. Commun. 2005)
    923. Leptin and its receptors in human fetal and adult ovaries. (PubMed id 16359991)1 Abir R....Fisch B. (Fertil. Steril. 2005)
    924. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. (PubMed id 15905523)1 Mattioli B....Viora M. (J. Immunol. 2005)
    925. Study of serum factors potentially involved in the pathogenesis of heterotopic bone formation after severe brain injury. (PubMed id 15797495)1 Rigaux P....Hardouin P. (Joint Bone Spine 2005)
    926. Serum and urine leptin concentration in children with nephrotic syndrome. (PubMed id 15782310)1 Wasilewska A....Koput A. (Pediatr. Nephrol. 2005)
    927. Serum leptin and lactational amenorrhea in well-nourished and undernourished lactating women. (PubMed id 15820811)1 Tennekoon K.H....Karunanayake E.H. (Fertil. Steril. 2005)
    928. Salivary leptin induces increased expression of growth factors in oral keratinocytes. (PubMed id 15821102)1 GrAPschl M....Rauh M. (J. Mol. Endocrinol. 2005)
    929. [Study of the impact of candidate genes on bone mineral density in postmenopausal women]. (PubMed id 16412323)1 Zhao H.Y....Chen J.L. (Zhonghua Fu Chan Ke Za Zhi 2005)
    930. Maternal recreational physical activity is associated with plasma leptin concentrations in early pregnancy. (PubMed id 15576385)1 Ning Y....Sorensen T.K. (Hum. Reprod. 2005)
    931. Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects. (PubMed id 16273647)1 MAcndez-SA!nchez N....Uribe M. (World J. Gastroenterol. 2005)
    932. The postoperative stress response and its reflection in cytokine network and leptin plasma levels. (PubMed id 15588161)1 Chachkhiani I....Lindner J. (Physiol Res 2005)
    933. Independent association between leptin and blood pressure during third trimester in normal and gestational diabetic pregnancies. (PubMed id 15808376)1 Buhling K.J....Dudenhausen J.W. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2005)
    934. Coelomic fluid leptin concentration in normal first-trimester pregnancies and missed miscarriages. (PubMed id 16113562)1 Makrydimas G....Nicolaides K.H. (Fetal. Diagn. Ther. 2005)
    935. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)1 Martens N....Gertler A. (J. Biol. Chem. 2005)
    936. Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. (PubMed id 15864530)1 Scarpace P.J....Zhang Y. (Diabetologia 2005)
    937. Apoptotic pathways are inhibited by leptin receptor activation in neutrophils. (PubMed id 15944317)1 Bruno A....Simon H.U. (J. Immunol. 2005)
    938. Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists. (PubMed id 15952938)1 Niv-Spector L....Gertler A. (Biochem. J. 2005)
    939. Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. (PubMed id 15724240)1 Mabuchi T....Toyoshima H. (Diabetes Metab. Res. Rev. 2005)
    940. Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents. (PubMed id 15660115)1 GuA-zar-Mendoza J.M....SA!nchez-Corona J. (J Hum Hypertens 2005)
    941. Correlation of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function in Chinese patients with chronic hepatitis C virus infection. (PubMed id 15948239)1 Liu Z.W....Wang X.Q. (World J. Gastroenterol. 2005)
    942. Relationship between leptin and bone mineral density in renal transplant recipients. (PubMed id 16213321)1 Agras P.I....Haberal M. (Transplant. Proc. 2005)
    943. Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. (PubMed id 15677491)1 Ducroc R....Bado A. (Diabetes 2005)
    944. Effects of different weight loss protocols on serum leptin levels in obese females. (PubMed id 15588160)1 Ozcelik O....Kelestimur H. (Physiol Res 2005)
    945. Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. (PubMed id 15736103)1 Inoue M....Suzuki S. (Metab. Clin. Exp. 2005)
    946. Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats. (PubMed id 16166222)1 van Dijk G....Scheurink A.J. (Endocrinology 2005)
    947. The leptin system during human endometrial receptivity and preimplantation development. (PubMed id 15126576)1 Cervero A....SimA^n C. (J. Clin. Endocrinol. Metab. 2004)
    948. Serum leptin levels in patients with idiopathic thrombocytopenic purpura. (PubMed id 15059070)1 Zhan M....Han Z.C. (Eur. J. Haematol. 2004)
    949. Effects of leptin and leptin fragments on corticosterone secretion and growth of cultured rat adrenocortical cells. (PubMed id 15492859)1 Malendowicz L.K....Rucinski M. (Int. J. Mol. Med. 2004)
    950. Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population. (PubMed id 15254881)1 Ogawa T....Saruta T. (Metab. Clin. Exp. 2004)
    951. Serum leptin concentrations in patients with severe ovarian hyperstimulation syndrome during in vitro fertilization-embryo transfer treatment. (PubMed id 15374699)1 Ayustawati ....Suzuki M. (Fertil. Steril. 2004)
    952. Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates. (PubMed id 15181040)1 Wong S.L....Mantzoros C.S. (J. Clin. Endocrinol. Metab. 2004)
    953. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. (PubMed id 15478389)1 Gurkan F....Mete N. (amp 2004)
    954. Relationship between plasma leptin and zinc levels and the effect of insulin and oxidative stress on leptin levels in obese diabetic patients. (PubMed id 15607649)1 Konukoglu D....Serin O. (J. Nutr. Biochem. 2004)
    955. Leptin levels in the acute stage of ulcerative colitis. (PubMed id 15012781)1 Tuzun A....Dagalp K. (J. Gastroenterol. Hepatol. 2004)
    956. Leptin regulation of the thyroids: negative regulation on thyroid hormone levels in euthyroid subjects and inhibitory effects on iodide uptake and Na+/I- symporter mRNA expression in rat FRTL-5 cells. (PubMed id 15351798)1 Isozaki O....Takano K. (Endocr. J. 2004)
    957. Leptin and prolactin modulate the expression of SOCS-1 in association with interleukin-6 and tumor necrosis factor-alpha in mammary cells: a role in differentiated secretory epithelium. (PubMed id 15256287)1 Motta M....Baratta M. (Regul. Pept. 2004)
    958. Leptin and altitude in the cardiovascular diseases. (PubMed id 15483214)1 Cabrera de LeA^n A....Trujillo I.C. (Obes. Res. 2004)
    959. Leptin expression in breast nipple aspirate fluid (NAF) and serum is influenced by body mass index (BMI) but not by the presence of breast cancer. (PubMed id 15156414)1 Sauter E.R....Surmacz E. (Horm. Metab. Res. 2004)
    960. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. (PubMed id 15231997)1 Yildiz B.O....Licinio J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    961. Comparison of leptin gene expression in different adipose tissues in children and adults. (PubMed id 15080789)1 Schoof E....DAPtsch J. (Eur. J. Endocrinol. 2004)
    962. Rapid inhibition of leptin signaling by glucocorticoids in vitro and in vivo. (PubMed id 14993217)1 Ishida-Takahashi R....Eguchi K. (J. Biol. Chem. 2004)
    963. The leptin receptor in human osteoblasts and the direct effect of leptin on bone metabolism. (PubMed id 15624271)1 Iwamoto I....Douchi T. (Gynecol. Endocrinol. 2004)
    964. Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients. (PubMed id 15324935)1 Chatzantoni K....Mouzaki A. (J. Autoimmun. 2004)
    965. Serum leptin values in relation to bone density and growth hormone-insulin like growth factors axis in healthy men. (PubMed id 14761840)1 Papadopoulou F....Constantinidis T.C. (Arch. Androl. 2004)
    966. Leptin and nitric oxide production in normotensive and hypertensive men. (PubMed id 15340103)1 Tsuda K. and Nishio I. (Obes. Res. 2004)
    967. Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice. (PubMed id 15126241)1 Delporte M.L....Brichard S.M. (Am. J. Physiol. Endocrinol. Metab. 2004)
    968. Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. (PubMed id 15277432)1 Morales A....Atkinson M. (Diabetes Care 2004)
    969. Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartments. (PubMed id 14715859)1 Wong M.L....Gold P.W. (J. Clin. Endocrinol. Metab. 2004)
    970. Relationship between serum adiponectin and leptin concentrations and body fat distribution. (PubMed id 14739054)1 Park K.G....Lee I.K. (Diabetes Res. Clin. Pract. 2004)
    971. Modulation of direct leptin signaling by soluble leptin receptor. (PubMed id 15016839)1 Yang G....Li C. (Mol. Endocrinol. 2004)
    972. Enhanced long-term reduction of plasma leptin concentrations by super-flux polysulfone dialysers. (PubMed id 14993491)1 van Tellingen A....NubAc M.J. (Nephrol. Dial. Transplant. 2004)
    973. Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor. (PubMed id 15336575)1 Shimamura M....Shimomura I. (Biochem. Biophys. Res. Commun. 2004)
    974. Determinants of plasma leptin concentration in postmenopausal women. (PubMed id 15037014)1 Brooks-Asplund E.M....Cannon J.G. (Mech. Ageing Dev. 2004)
    975. Elevation of breast milk leptin levels by laughter. (PubMed id 15114526)1 Kimata H. (Horm. Metab. Res. 2004)
    976. [Bone mass regulation by leptin: a hypothalamic control of bone formation]. (PubMed id 15063934)1 Elefteriou F. and Karsenty G. (Pathol. Biol. 2004)
    977. Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase. (PubMed id 12902351)1 Onuma M....Iwamoto Y. (J. Biol. Chem. 2003)
    978. Circadian rhythmicity of salivary leptin in healthy subjects. (PubMed id 12649069)1 Randeva H.S....Hillhouse E.W. (Mol. Genet. Metab. 2003)
    979. Inverse correlation between peritoneal fluid leptin concentrations and the extent of endometriosis. (PubMed id 12773447)1 Mahutte N.G....Arici A. (Hum. Reprod. 2003)
    980. Serum leptin levels in neonatal bacterial septicemia. (PubMed id 12880122)1 Orbak Z....Ors R. (amp 2003)
    981. Maternal and umbilical cord serum leptin concentrations in small-for-gestational-age and in appropriate-for-gestational-age neonates: a maternal, fetal, or placental contribution? (PubMed id 12890940)1 Grisaru-Granovsky S....Samueloff A. (Biol. Neonate 2003)
    982. The-2548G/A polymorphism in the human leptin gene promoter region is associated with plasma free leptin levels; interaction with adiposity and gender in healthy subjects. (PubMed id 17003027)1 Yiannakouris N....Mantzoros C.S. (Hormones (Athens) 2003)
    983. Serum leptin, prolactin and vascular endothelial growth factor (VEGF) levels in patients with breast cancer. (PubMed id 12687277)1 Coskun U....Ozkan S. (Neoplasma 2003)
    984. Serum leptin levels, bone mineral density and osteoblast alkaline phosphatase activity in elderly men and women. (PubMed id 12663125)1 Scariano J.K....Baumgartner R.N. (Mech. Ageing Dev. 2003)
    985. Potential association between endogenous leptin and sympatho-vagal activities in young obese Japanese women. (PubMed id 12552573)1 Matsumoto T....Moritani T. (Am. J. Hum. Biol. 2003)
    986. Association between serum leptin levels and 24-hour blood pressure in obese women. (PubMed id 12690084)1 Guagnano M.T....DavA- G. (Obes. Res. 2003)
    987. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (Science 2003)
    988. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. (PubMed id 12634434)1 van Rossum C.T....Seidell J.C. (Obes. Res. 2003)
    989. [Blood leptin level of 154 Chinese children 0 - 14 years of age]. (PubMed id 14746672)1 Ding Z.Y....Du L.R. (Zhonghua Er Ke Za Zhi 2003)
    990. Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells. (PubMed id 12665505)1 Kim G.S....Cheng S.L. (J. Biol. Chem. 2003)
    991. Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines. (PubMed id 12590942)1 Muraoka O....Higuchi H. (Neurochem. Int. 2003)
    992. Serum leptin activity in obese and lean patients. (PubMed id 12609752)1 Friedman-Einat M....Strosberg A.D. (Regul. Pept. 2003)
    993. Leptin response to short-term fasting in sympathectomized men: role of the SNS. (PubMed id 12556356)1 Jeon J.Y....Steadward R.D. (Am. J. Physiol. Endocrinol. Metab. 2003)
    994. Leptin: a potential marker of placental insufficiency. (PubMed id 12865594)1 Lepercq J....Hauguel-de Mouzon S. (Gynecol. Obstet. Invest. 2003)
    995. Leptin and leptin receptor in human seminal plasma and in human spermatozoa. (PubMed id 14636218)1 Jope T....Glander H.J. (Int. J. Androl. 2003)
    996. Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. (PubMed id 12788897)1 Gavrila A....Mantzoros C.S. (J. Clin. Endocrinol. Metab. 2003)
    997. The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men. (PubMed id 12637980)1 Zitzmann M....Nieschlag E. (Diabetologia 2003)
    998. Relation between leptin and body fat distribution in menopausal status. (PubMed id 15164950)1 MartA-nez-Carpio P.A....Corominas A. (J. Physiol. Biochem. 2003)
    999. Bound leptin and sympathetic outflow in nonobese men. (PubMed id 14557480)1 Tank J....Brabant G. (J. Clin. Endocrinol. Metab. 2003)
    1000. Leptin response to glucocorticoid occurs at physiological doses and is abolished by fasting. (PubMed id 12582219)1 Dagogo-Jack S....Tykodi G. (Obes. Res. 2003)
    1001. Leptin, soluble leptin receptor, and transforming growth factor-beta1 levels in minimal change nephrotic syndrome. (PubMed id 12898374)1 Buyan N....HasanoA9lu E. (Pediatr. Nephrol. 2003)
    1002. Relationships between the serum levels of soluble leptin receptor and free and bound leptin in non-pregnant women of reproductive age and women undergoing controlled ovarian hyperstimulation. (PubMed id 12660261)1 Kado N....Honjo H. (Hum. Reprod. 2003)
    1003. Intact sympathetic nervous system is required for leptin effects on resting metabolic rate in people with spinal cord injury. (PubMed id 12519883)1 Jeon J.Y....Harber V. (J. Clin. Endocrinol. Metab. 2003)
    1004. Stearoyl-CoA desaturase-1 and the metabolic syndrome. (PubMed id 14683458)1 Cohen P....Friedman J.M. (Curr. Drug Targets Immune Endocr. Metabol. Disord. 2003)
    1005. Influence of physical training on plasma leptin in obese youths. (PubMed id 12955866)1 Barbeau P....Owens S. (Can J Appl Physiol 2003)
    1006. C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. (PubMed id 14506615)1 Kazumi T....Yoshino G. (Metab. Clin. Exp. 2003)
    1007. Leptin and cytokines levels in children with failure to thrive. (PubMed id 14508221)1 Shaoul R....Jaffe M. (J. Pediatr. Gastroenterol. Nutr. 2003)
    1008. Fat body mass, leptin and femur bone mineral density in hip-fractured women. (PubMed id 15055469)1 Di Monaco M....Cavanna A. (J. Endocrinol. Invest. 2003)
    1009. Plasma leptin, fatty acids, and tumor necrosis factor-receptor and insulin resistance in children. (PubMed id 12690082)1 Chu N.F....Shieh S.M. (Obes. Res. 2003)
    1010. Free-to-total leptin ratio in maternal plasma is constant throughout human pregnancy. (PubMed id 14599116)1 Nuamah M.A....Fujii S. (Endocr. J. 2003)
    1011. Comparative analysis of expression and secretion of placental leptin in mammals. (PubMed id 12702488)1 Zhao J....Widmaier E.P. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003)
    1012. Amniotic fluid and maternal serum leptin levels in pregnant women who subsequently develop preeclampsia. (PubMed id 12694970)1 Chan T.F....Yuan S.S. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2003)
    1013. Leptin and bone mineral density: a cross-sectional study in obese and nonobese men. (PubMed id 14671171)1 Morberg C.M....Astrup A. (J. Clin. Endocrinol. Metab. 2003)
    1014. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. (PubMed id 12899679)1 Mullington J.M....Mantzoros C.S. (J. Neuroendocrinol. 2003)
    1015. A model for modulation of leptin activity by association with clusterin. (PubMed id 12824284)1 Bajari T.M....Schneider W.J. (FASEB J. 2003)
    1016. IP-10, but not RANTES, is upregulated by leptin in monocytic cells. (PubMed id 12668159)1 Meier C.A....Dayer J.M. (Cytokine 2003)
    1017. Polymorphisms in exon 3 of the proopiomelanocortin gene in relation to serum leptin, salivary cortisol, and obesity in Swedish men. (PubMed id 11979399)1 Rosmond R....BjAPrntorp P. (Metab. Clin. Exp. 2002)
    1018. Serum leptin levels in patients with premature ejaculation. (PubMed id 12230820)1 Atmaca M....Ayar A. (Arch. Androl. 2002)
    1019. Prediction of exercise-mediated changes in metabolic markers by gene polymorphism. (PubMed id 12062855)1 Kahara T....Kobayashi K. (Diabetes Res. Clin. Pract. 2002)
    1020. Serum leptin level and restrained eating: study with the Eating Disorder Examination. (PubMed id 11890967)1 Adami G....Ferrandes G. (amp 2002)
    1021. Differences in leptin production by regional fat mass in postmenopausal women. (PubMed id 12402972)1 Douchi T....Nagata Y. (Endocr. J. 2002)
    1022. Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes. (PubMed id 12010881)1 Barrenetxe J....Lostao M.P. (Gut 2002)
    1023. Genetic diversity and evolution of the human leptin locus tetranucleotide repeat. (PubMed id 12073010)1 Moffett S....Ferrell R.E. (Hum. Genet. 2002)
    1024. Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2. (PubMed id 11997181)1 Gualillo O....Casanueva F.F. (Mol. Cell. Endocrinol. 2002)
    1025. Leptin enhances the effect of transforming growth factor beta in increasing type I collagen formation. (PubMed id 12359239)1 Tang M....Mezey E. (Biochem. Biophys. Res. Commun. 2002)
    1026. Serum leptin levels of menopausal women before and after hormone replacement therapy. (PubMed id 12376297)1 Li W.L....Zhang Y.L. (Di Yi Jun Yi Da Xue Xue Bao 2002)
    1027. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    1028. Role of leptin in glucose metabolism in type 2 diabetes. (PubMed id 12047393)1 Al-Daghri N....Kumar S. (amp 2002)
    1029. [The changes in plasma leptin, insulin and proinsulin levels in obese adolescents]. (PubMed id 12133430)1 Zhang J....Dong A. (Zhonghua Nei Ke Za Zhi 2002)
    1030. Leptin induces endothelin-1 in endothelial cells in vitro. (PubMed id 11934840)1 Quehenberger P....Wagner O. (Circ. Res. 2002)
    1031. Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin. (PubMed id 12105280)1 Laimer M....Patsch J.R. (Obes. Res. 2002)
    1032. Leptin mediates a proliferative response in human MCF7 breast cancer cells. (PubMed id 12054648)1 Dieudonne M.N....Giudicelli Y. (Biochem. Biophys. Res. Commun. 2002)
    1033. Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. (PubMed id 12213831)1 Melzner I....MAPller P. (J. Biol. Chem. 2002)
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    1035. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. (PubMed id 12086939)1 Chan J.L....Mantzoros C.S. (Diabetes 2002)
    1036. Leptin concentrations experience a delayed reduction after resistance exercise in men. (PubMed id 11932568)1 Nindl B.C....Hafeman D.L. (Med Sci Sports Exerc 2002)
    1037. Maternal serum leptin concentration during the second trimester of pregnancy: association with fetal chromosomal abnormalities. (PubMed id 11920898)1 Rizos D....Salamalekis E. (Prenat. Diagn. 2002)
    1038. A quantitative trait locus on chromosome 22 for serum leptin levels adjusted for serum testosterone. (PubMed id 12105281)1 Martin L.J....Comuzzie A.G. (Obes. Res. 2002)
    1039. Leptin and the treatment of obesity: its current status. (PubMed id 12007531)1 Lee D.W....Grasso P. (Eur. J. Pharmacol. 2002)
    1040. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. (PubMed id 12215445)1 Grosfeld A....Guerre-Millo M. (J. Biol. Chem. 2002)
    1041. Relationship between changes in serum leptin levels and blood pressure after weight loss. (PubMed id 12484512)1 Itoh K....Nakamura M. (Hypertens. Res. 2002)
    1042. Secretion of free and protein-bound leptin from subcutaneous adipose tissue of lean and obese women. (PubMed id 12161541)1 Brabant G....Arner P. (J. Clin. Endocrinol. Metab. 2002)
    1043. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. (PubMed id 12153737)1 Matsubara M....Katayose S. (Eur. J. Endocrinol. 2002)
    1044. A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response. (PubMed id 14561193)1 Waelput W....Tavernier J. (Curr Drug Targets Inflamm Allergy 2002)
    1045. Higher serum leptin level in women than in men with type 1 diabetes. (PubMed id 12003376)1 Azar S.T....Zalloua P.A. (Am. J. Med. Sci. 2002)
    1046. Leptin in human acute myelogenous leukemia: studies of in vivo levels and in vitro effects on native functional leukemia blasts. (PubMed id 12031914)1 Bruserud A.9....Foss B. (Haematologica 2002)
    1047. Novel peptide-peptide cooperation may transform feeding behavior. (PubMed id 12535698)1 Kastin A.J....Kotz C.M. (Peptides 2002)
    1048. Insulin and leptin combine additively to reduce food intake and body weight in rats. (PubMed id 12021212)1 Air E.L....Woods S.C. (Endocrinology 2002)
    1049. Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. (PubMed id 12084725)1 Ambrosini G....Flores-Riveros J. (J. Biol. Chem. 2002)
    1050. Human umbilical cord and fetal membranes co-express leptin and its receptor genes. (PubMed id 12396559)1 Akerman F....Rao C.V. (Gynecol. Endocrinol. 2002)
    1051. Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line. (PubMed id 12354677)1 Kaszubska W....Trevillyan J.M. (Mol. Cell. Endocrinol. 2002)
    1052. Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. (PubMed id 12482897)1 Shanley L.J....Harvey J. (J. Physiol. (Lond.) 2002)
    1053. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. (PubMed id 11797013)1 Minokoshi Y....Kahn B.B. (Nature 2002)
    1054. Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. (PubMed id 12149424)1 Lord G.M....Lechler R.I. (J. Leukoc. Biol. 2002)
    1055. Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. (PubMed id 12100031)1 SA!nchez-Margalet V....Muniain M.A. (Clin. Exp. Immunol. 2002)
    1056. Human follicular papilla cells carry out nonadipose tissue production of leptin. (PubMed id 11886494)1 Iguchi M....Tagami H. (J. Invest. Dermatol. 2001)
    1057. A role for ghrelin in the central regulation of feeding. (PubMed id 11196643)1 Nakazato M....Matsukura S. (Nature 2001)
    1058. Human milk contains detectable levels of immunoreactive leptin. (PubMed id 11787735)1 Lyle R.E....McGehee R.E. (Adv. Exp. Med. Biol. 2001)
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    1060. Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase. (PubMed id 11068878)1 Sui D. and Wilson J.E. (Arch. Biochem. Biophys. 2000)
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    1063. Human leptin forms complexes with alpha 2-macroglobulin which are recognized by the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. (PubMed id 9724081)1 Birkenmeier G....Schellenberger W. (Eur. J. Endocrinol. 1998)
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    1073. The ovarian expression of mRNAs for aromatase, IGF-I receptor, IGF-binding protein-2, -4 and -5, leptin and leptin receptor in cycling ewes after three days of leptin infusion. (PubMed id 16322546)9 MuA+oz-GutiAcrrez M....Scaramuzzi R.J. (Reproduction 2005)
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    1081. Multihormonal control of ob gene expression and leptin secretion from cultured human visceral adipose tissue: increased responsiveness to glucocorticoids in obesity. (PubMed id 9506746)9 Halleux C.M....Brichard S.M. (J. Clin. Endocrinol. Metab. 1998)
    1082. Higher leptin levels in Asian Indians than Creoles and Europids: a potential explanation for increased metabolic risk. (PubMed id 20125099)9 Lilja M....SAPderberg S. (Int J Obes (Lond) 2010)
    1083. Measurements of urinary leptin and capillary leptin: alternative tools for the assessment of the leptin status? (PubMed id 11847469)9 Dimitriou T....Remer T. (Horm. Res. 2001)
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    1085. Leptin measurement in urine in children and its relationship to other growth peptides in serum and urine. (PubMed id 12519416)9 Zaman N....Clayton P.E. (Clin. Endocrinol. (Oxf) 2003)
    1086. The inhibition of growth hormone secretion presented in obesity is not mediated by the high leptin levels: a study in human leptin deficiency patients. (PubMed id 12519870)9 Ozata M....Casanueva F.F. (J. Clin. Endocrinol. Metab. 2003)
    1087. Leptin and the pituitary. (PubMed id 11824510)9 Popovic V....Casanueva F.F. (Pituitary 2001)
    1088. Short-term fasting selectively suppresses leptin pulse mass and 24-hour rhythmic leptin release in healthy midluteal phase women without disturbing leptin pulse frequency or its entropy control (pattern orderliness). (PubMed id 10634388)9 Bergendahl M....Veldhuis J.D. (J. Clin. Endocrinol. Metab. 2000)
    1089. Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA. (PubMed id 10856891)9 Kauter K....McFarlane J.R. (J. Endocrinol. 2000)
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    1091. Distribution of plasma levels of adiponectin and leptin in an adult Caucasian population. (PubMed id 19473178)9 Marques-Vidal P....Vollenweider P. (Clin. Endocrinol. (Oxf) 2010)
    1092. Clinicopathologic significance of leptin and leptin receptor expressions in papillary thyroid carcinoma. (PubMed id 20045163)9 Cheng S.P....Liu C.L. (Surgery 2010)
    1093. Effects of seafood consumption and weight loss on fasting leptin and ghrelin concentrations in overweight and obese European young adults. (PubMed id 19142567)9 Ramel A....Thorsdottir I. (Eur J Nutr 2009)
    1094. Effects of leptin on in vitro maturation, fertilization and embryonic cleavage after ICSI and early developmental expression of leptin (Ob) and leptin receptor (ObR) proteins in the horse. (PubMed id 19835605)9 Lange Consiglio A....Cremonesi F. (amp 2009)
    1095. Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin. (PubMed id 18387655)9 Eriksson M....SAPderberg S. (Thromb. Res. 2008)
    1096. Leptin and TNF-alpha levels in patients with chronic obstructive pulmonary disease and their relationship to nutritional parameters. (PubMed id 14872110)9 Calikoglu M....Atik U. ( international review of thoracic diseases 2004)
    1097. Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis. (PubMed id 15049957)9 Stamatiadis D.N....Mantzoros C.S. (Clin. Endocrinol. (Oxf) 2004)
    1098. Endocrine responses in mares and geldings with high body condition scores grouped by high vs. low resting leptin concentrations. (PubMed id 12968707)9 Cartmill J.A....Huff N.K. (J. Anim. Sci. 2003)
    1099. Gender variation in leptin circadian rhythm and pulsatility in adult growth hormone deficiency: effects of growth hormone replacement. (PubMed id 12641632)9 White H.D....Vora J.P. (Clin. Endocrinol. (Oxf) 2003)
    1100. Immaturity or starvation? Longitudinal study of leptin levels in premature infants. (PubMed id 11474147)9 Spear M.L....Funanage V.L. (Biol. Neonate 2001)
    1101. Leptin and its role in lipid metabolism. (PubMed id 11353336)9 Hynes G.R. and Jones P.J. (Curr. Opin. Lipidol. 2001)
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    1104. Leptin inhibits testosterone secretion from adult rat testis in vitro. (PubMed id 10320818)9 Tena-Sempere M....Aguilar E. (J. Endocrinol. 1999)
    1105. Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry. (PubMed id 10509783)9 Schubring C....Kiess W. (Eur. J. Obstet. Gynecol. Reprod. Biol. 1999)
    1106. The role of SOCS-3 in leptin signaling and leptin resistance. (PubMed id 10514492)9 BjA...Flier J.S. (J. Biol. Chem. 1999)
    1107. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. (PubMed id 9626154)9 Casabiell X....Casanueva F.F. (J. Clin. Endocrinol. Metab. 1998)
    1108. The effect of exercise on leptin concentration in healthy men and in type 1 diabetic patients. (PubMed id 9624635)9 Koistinen H.A....Koivisto V.A. (Med Sci Sports Exerc 1998)
    1109. Leptin concentrations are associated with higher proinsulin and insulin concentrations but a lower proinsulin/insulin ratio in non-diabetic subjects. (PubMed id 9756249)9 Haffner S.M....Stern M.P. (Int. J. Obes. Relat. Metab. Disord. 1998)
    1110. Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. (PubMed id 9768648)9 Klein K.O....Hassink S.G. (J. Clin. Endocrinol. Metab. 1998)
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    1112. Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis. (PubMed id 17509098)9 Ockenga J....Bahr M.J. (amp 2007)
    1113. Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion. (PubMed id 16219000)9 Sahu A. and Metlakunta A.S. (J. Neuroendocrinol. 2005)
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    1116. Evidence for a key role of leptin in osteoarthritis. (PubMed id 14613274)9 Dumond H....Pottie P. (Arthritis Rheum. 2003)
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    1118. Endotoxin stimulates leptin in the human and nonhuman primate. (PubMed id 12629120)9 Landman R.E....Wardlaw S.L. (J. Clin. Endocrinol. Metab. 2003)
    1119. Leptin and renal disease. (PubMed id 11774095)9 Wolf G....Ziyadeh F.N. (Am. J. Kidney Dis. 2002)
    1120. Perspectives in the therapeutic use of leptin. (PubMed id 11825304)9 Salvador J....FrA1hbeck G. (Expert Opin Pharmacother 2001)
    1121. Heritability of leptin levels and the shared genetic effects on body mass index and leptin in adult Finnish twins. (PubMed id 11244469)9 Kaprio J....Tuomilehto J. (Int. J. Obes. Relat. Metab. Disord. 2001)
    1122. Leptin and the hypothalamic-pituitary regulation of the gonadotropin-gonadal axis. (PubMed id 11824513)9 Chan J.L. and Mantzoros C.S. (Pituitary 2001)
    1123. Regulation of the leptin content of obese human adipose tissue. (PubMed id 11171593)9 Russell C.D....Fried S.K. (Am. J. Physiol. Endocrinol. Metab. 2001)
    1124. Human leptin regulation and promise in pharmacotherapy. (PubMed id 11469718)9 Dagogo-Jack S. (Curr Drug Targets 2001)
    1125. Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy. (PubMed id 11336170)9 Widjaja A....Brabant G. (Scand. J. Gastroenterol. 2001)
    1126. Effects of growth hormone on leptin metabolism and energy expenditure in hemodialysis patients with protein-calorie malnutrition. (PubMed id 11053487)9 Garibotto G....Barreca T. (J. Am. Soc. Nephrol. 2000)
    1127. Are circulating leptin and luteinizing hormone synchronized in patients with polycystic ovary syndrome? (PubMed id 10357954)9 Sir-Petermann T....Wildt L. (Hum. Reprod. 1999)
    1128. Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels. (PubMed id 9873196)9 Schubring C....Kiess W. (Horm. Res. 1998)
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    1130. High plasma levels of adipocytokines are associated with platelet activation in patients with coronary artery disease. (PubMed id 19954410)9 Bigalke B....Gawaz M. (Platelets 2010)
    1131. Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. (PubMed id 20164331)9 Williams K.W....Elmquist J.K. (J. Neurosci. 2010)
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    1133. Comparison of adiponectin, leptin and leptin to adiponectin ratio as diagnostic marker for metabolic syndrome in older adults of Chinese major cities. (PubMed id 19181412)9 Zhuo Q....Yang X. (Diabetes Res. Clin. Pract. 2009)
    1134. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. (PubMed id 18926322)9 Martin S.S....Reilly M.P. (J. Am. Coll. Cardiol. 2008)
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    1136. Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. (PubMed id 17487372)9 Ray A....Cleary M.P. (Int. J. Oncol. 2007)
    1137. Baseline leptin levels predict change in leptin levels during weight loss in obese breast cancer survivors. (PubMed id 17319860)9 Sen A....Djuric Z. (Breast J 2007)
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    1141. Regulatory roles of leptin in reproduction and metabolism: a comparative review. (PubMed id 15927772)9 Zieba D.A....Williams G.L. (Domest. Anim. Endocrinol. 2005)
    1142. Ghrelin and leptin elevation in postoperative intra-abdominal sepsis. (PubMed id 16465060)9 Maruna P....Rosicka M. (Eur Surg Res 2005)
    1143. Leptin profile in neonatal gonadotropin surge and relationship between leptin and body mass index in early infancy. (PubMed id 15751608)9 Akcurin S....Guntekin M. (amp 2005)
    1144. Relationship of leptin concentration to gender, body mass index and age in Saudi adults. (PubMed id 15322603)9 Al-Harithy R.N. (Saudi Med J 2004)
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    1148. Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome. (PubMed id 12805397)9 Sandhofer A....Patsch J.R. (Obes. Res. 2003)
    1149. The regulation of IGF-1 by leptin in the pig is tissue specific and independent of changes in growth hormone. (PubMed id 14505814)9 Ajuwon K.M....Spurlock M.E. (J. Nutr. Biochem. 2003)
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    1152. Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats. (PubMed id 11604238)9 Almog B....Amsterdam A. (Mol. Cell. Endocrinol. 2001)
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    1154. Alcohol ingestion decreases both diurnal and nocturnal secretion of leptin in healthy individuals. (PubMed id 11894976)9 RAPjdmark S....Brismar K. (Clin. Endocrinol. (Oxf) 2001)
    1155. Leptin, cortisol, and GH secretion interactions in short normal prepubertal children. (PubMed id 11502803)9 Ghizzoni L....Bernasconi S. (J. Clin. Endocrinol. Metab. 2001)
    1156. Increased weight gain after ovariectomy is not a consequence of leptin resistance. (PubMed id 11158936)9 Chen Y. and Heiman M.L. (Am. J. Physiol. Endocrinol. Metab. 2001)
    1157. Serum lipid and leptin concentrations in hypopituitary patients with growth hormone deficiency. (PubMed id 10849585)9 Ozbey N....Molvalilar S. (Int. J. Obes. Relat. Metab. Disord. 2000)
    1158. Elevated circulating leptin levels in arterial hypertension: relationship to arteriovenous overflow and extraction of leptin. (PubMed id 11099396)9 Henriksen J.H....Jensen G. (Clin. Sci. 2000)
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    1163. Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal. (PubMed id 10347125)9 Henriksen J.H....Bendtsen F. (Hepatology 1999)
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    1174. Effects of leptin on intracellular calcium concentrations in isolated porcine somatotropes. (PubMed id 15528950)9 Glavaski-Joksimovic A....Jeftinija S. (Neuroendocrinology 2004)
    1175. Leptin as a marker of nutrition and cardiovascular risk in peritoneal dialysis patients. (PubMed id 12402621)9 Aguilera A....Selgas R. (Adv Perit Dial 2002)
    1176. Characterization of leptin binding in bovine kidney membranes. (PubMed id 12206874)9 Margetic S....Hill R.A. (Domest. Anim. Endocrinol. 2002)
    1177. Disruption of the synchronous secretion of leptin, LH, and ovarian androgens in nonobese adolescents with the polycystic ovarian syndrome. (PubMed id 11502810)9 Veldhuis J.D....Barontini M. (J. Clin. Endocrinol. Metab. 2001)
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    1179. Circulating leptin and the perioperative neuroendocrinological stress response after pediatric cardiac surgery. (PubMed id 11801844)9 Modan-Moses D....Paret G. (Crit. Care Med. 2001)
    1180. Circadian and ultradian rhythm and leptin pulsatility in adult GH deficiency: effects of GH replacement. (PubMed id 11502770)9 Ahmad A.M....Vora J.P. (J. Clin. Endocrinol. Metab. 2001)
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    1186. Alteration of PON1 activity in adult and childhood obesity and its relation to adipokine levels. (PubMed id 20221876)9 Seres I....Paragh G. (Adv. Exp. Med. Biol. 2010)
    1187. Diet determines features of the metabolic syndrome in 6- to 14-year-old children. (PubMed id 19838999)9 Aeberli I....Zimmermann M.B. (Int J Vitam Nutr Res 2009)
    1188. Appetite responds to changes in meal content, whereas ghrelin, leptin, and insulin track changes in energy availability. (PubMed id 19401375)9 Borer K.T....Burant C. (J. Clin. Endocrinol. Metab. 2009)
    1189. Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies. (PubMed id 19661131)9 JardAc T....Vasson M.P. (Endocr. Relat. Cancer 2009)
    1190. Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: comparison of leptin and adiponectin. (PubMed id 18495270)9 Sugiura K....Toyoshima H. (Int. J. Cardiol. 2008)
    1191. Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor. (PubMed id 19047149)9 Saxena N.K....Sharma D. (Cancer Res. 2008)
    1192. Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus. (PubMed id 17170237)9 Canabal D.D....Routh V.H. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007)
    1193. TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. (PubMed id 17459524)9 Romanatto T....Velloso L.A. (Peptides 2007)
    1194. Ghrelin and leptin levels in patients with obsessive-compulsive disorder. (PubMed id 17597276)9 EmA1l H.M....Gecici O. (amp 2007)
    1195. Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseases. (PubMed id 17207790)9 Elbatarny H.S....Maurice D.H. (Eur. J. Pharmacol. 2007)
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    1197. Tumor necrosis factor alpha and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase. (PubMed id 16403817)9 Trujillo M.E....Fried S.K. (J. Clin. Endocrinol. Metab. 2006)
    1198. Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. (PubMed id 16324751)9 Jow G.M....Chen C.L. (J Affect Disord 2006)
    1199. Pancreatic polypeptide in obese children before and after weight loss. (PubMed id 16702998)9 Reinehr T....Roth C.L. (Int J Obes (Lond) 2006)
    1200. Leptin secretion in horses: effects of dexamethasone, gender, and testosterone. (PubMed id 16305819)9 Cartmill J.A....Crowley J.C. (Domest. Anim. Endocrinol. 2006)
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    1202. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. (PubMed id 16091494)9 Fatouros I.G....Mitrakou A. (J. Clin. Endocrinol. Metab. 2005)
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    1204. Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. (PubMed id 15805581)9 Han C....Tian B. (Endocrine 2005)
    1205. Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells. (PubMed id 16154199)9 Gasperi V....Maccarrone M. (Neurotoxicology 2005)
    1206. Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life. (PubMed id 16188739)9 Savino F....Silvestro L. (Acta Paediatr. 2005)
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    1231. Determina