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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

LEP Gene

protein-coding   GIFtS: 68
GCID: GC07P127881


(Previous names: leptin (murine obesity homolog), leptin (obesity homolog,...)
(Previous symbols: OBS, OB)
Microbiology & Infectious Diseases Congress
  See related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

leptin1 2     Obese Protein2 3
OB1 2 3 5     Obesity Factor2 3
OBS1 2 3     LEPD2
Leptin (Murine Obesity Homolog)1 2     Obese, Mouse, Homolog Of2
Leptin (Obesity Homolog, Mouse)1 2     

External Ids:    HGNC: 65531   Entrez Gene: 39522   Ensembl: ENSG000001746977   OMIM: 1641605   UniProtKB: P411593   

Export aliases for LEP gene to outside databases

Previous GC identifers: GC07P126358 GC07P127421 GC07P127435 GC07P127475 GC07P127668 GC07P122242

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LEP Gene:
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation
of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway
that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This
protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory
responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions
cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes
mellitus development. (provided by RefSeq, Jul 2008)

GeneCards Summary for LEP Gene: 
LEP (leptin) is a protein-coding gene. Diseases associated with LEP include morbid obesity, and leptin deficiency, and among its related super-pathways are Axon guidance and Development Leptin signaling via PI3K-dependent pathway. GO annotations related to this gene include growth factor activity and peptide hormone receptor binding.

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159
Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An
increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate
energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

summary for LEP Gene:
Leptin was initially thought to have a role in energy homeostasis and obesity. More recently, it has also
been implicated in the regulation of reproduction, glucose homeostasis, bone formation, wound healing and
the immune system. Leptin acts via leptin receptors, which are transmembrane catalytic receptors found on
NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one
human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at
physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so
through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates
transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid
expression. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese
individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier)
expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are
of great interest in the development of pharmacological treatments for obesity.

Gene Wiki entry for LEP (Leptin) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LEP gene promoter:
         GR   C/EBPbeta   AP-1   ATF-2   GR-beta   AP-2gamma   AREB6   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): LEP promoter sequence
   Search SABiosciences Chromatin IP Primers for LEP

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LEP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q31

LEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LEP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P127881:  view genomic region     (about GC identifiers)

127,881,331 bp from pter      End:
127,897,682 bp from pter
16,352 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 127,264,455-127,280,803     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159 (See protein sequence)
Recommended Name: Leptin precursor  
Size: 167 amino acids; 18641 Da
Subunit: Interacts with SIGLEC6
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for LEP:
1AX8 (3D)    
Secondary accessions: O15158 Q56A88

Explore the universe of human proteins at neXtProt for LEP: NX_P41159

Explore proteomics data for LEP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41159

  • LEP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LEP Protein Expression
    REFSEQ proteins: NP_000221.1  
    ENSEMBL proteins: 
    Reactome Protein details: P41159
    Human Recombinant Protein Products for LEP: 
    EMD Millipore Purified and/or Recombinant LEP Protein
    R&D Systems Recombinant & Natural Proteins for LEP (Leptin/OB)
    Enzo Life Sciences proteins for LEP
    OriGene Purified Protein for LEP
    OriGene Protein Over-expression Lysate for LEP
    OriGene MassSpec for LEP 
    OriGene Custom Protein Services for LEP
    GenScript Purified and Recombinant Proteins for LEP
    Novus Biologicals LEP Proteins
    Novus Biologicals LEP Lysate
    Sino Biological Recombinant Protein for LEP
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for LEP
    Cloud-Clone Corp. Proteins for LEP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm IEA--

    LEP for ontologies           About GeneDecksing

    LEP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LEP
    R&D Systems Antibodies for LEP (Leptin/OB)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LEP
    GenScript Superior Antibodies for LEP
    Novus Biologicals LEP Antibodies
    Abcam antibodies for LEP
    Cloud-Clone Corp. Antibodies for LEP 
    ThermoFisher Antibody for LEP
    LSBio Antibodies in human, mouse, rat for LEP 

    Assay Products for LEP: 
    EMD Millipore Kits and Assays for the Analysis of LEP
    OriGene Custom Assay Services for LEP
    R&D Systems ELISAs for LEP (Leptin/OB)         (see all)
    GenScript Custom Assay Services for LEP
    Enzo Life Sciences assays for LEP
    Cloud-Clone Corp. ELISAs for LEP 
    Cloud-Clone Corp. CLIAs for LEP

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR009079 4_helix_cytokine-like_core
     IPR012351 4_helix_cytokine_core
     IPR000065 Leptin

    Graphical View of Domain Structure for InterPro Entry P41159

    ProtoNet protein and cluster: P41159

    1 Blocks protein domain: IPB000065 Obesity factor (leptin) signature

    UniProtKB/Swiss-Prot: LEP_HUMAN, P41159
    Similarity: Belongs to the leptin family

    LEP for domains           About GeneDecksing

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEP_HUMAN, P41159
    Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An
    increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate
    energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

         Genatlas biochemistry entry for LEP:
    leptin,adipocyte-specific secreted protein,18.6kDa,controlling the size of adipose depot by a profound effect of
    appen appetite and energy expenditure,also involved in control of the hypothalamic-pituitary-gonadal (HPG)
    axis,also putative angiogenic factor,homolog of the murine obese gene (ob)

    During embryonic development, LEP as signaling molecule is secreted from the following cells: Subcutaneous White Adipocytes in Subcutaneous White Adipose, Subcutaneous White Adipocytes in Body Subcutaneous White Adipose (see all 6).

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0051428peptide hormone receptor binding IEA--
    LEP for ontologies           About GeneDecksing

         15/24 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Lep) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    LEP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LEP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LEP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LEP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LEP 

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LEP
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate LEP (see all 24):
    hsa-miR-498 hsa-miR-29a hsa-miR-29c hsa-miR-128 hsa-miR-27b* hsa-miR-9 hsa-miR-1276 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidLEP 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LEP

    Gene Editing
    DNA2.0 Custom Protein Engineering Service for LEP
    Sirion Biotech Customized adenovirus for overexpression of LEP

    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LEP (see all 7)
    OriGene ORF clones in mouse, rat for LEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LEP (NM_000230)
    Sino Biological Human cDNA Clone for LEP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEP
    Sirion Biotech Customized lentivirus for stable overexpression of LEP 
                         Customized lentivirus expression plasmids for stable overexpression of LEP 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for LEP
    Search LifeMap BioReagents cell lines for LEP
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEP

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LEP About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Developmental Biology0.69
    2Development Leptin signaling via PI3K-dependent pathway
    Development Leptin signaling via PI3K-dependent pathway1.00
    3Development Leptin signaling via JAK/STAT and MAPK cascades
    Development Leptin signaling via JAK/STAT and MAPK cascades1.00
    4PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    5Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for LEP
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Selected targets of GCR-alpha
    Development Leptin signaling via PI3K-dependent pathway

    1 R&D Systems Pathway for LEP
        Adipocytokines & Insulin Signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LEP
        AMPK Enzyme Complex Pathway

    2 GeneGo (Thomson Reuters) Pathways for LEP
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development Leptin signaling via PI3K-dependent pathway

    5/6 BioSystems Pathways for LEP (see all 6)
    AMPK signaling
    Spinal Cord Injury
    Leptin signaling pathway
    Signaling events mediated by PTP1B

    2        Reactome Pathways for LEP
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation

    5         Kegg Pathways  (Kegg details for LEP):
        Cytokine-cytokine receptor interaction
    Neuroactive ligand-receptor interaction
    Jak-STAT signaling pathway
    Adipocytokine signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)

    LEP for pathways           About GeneDecksing


        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for LEP (P411593 ENSP000003126524) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAA2P546463, ENSP000003602904I2D: score=1 STRING: ENSP00000360290
    UCNP550893, ENSP000002960994I2D: score=1 STRING: ENSP00000296099
    LEPRP483573, ENSP000003303934I2D: score=2 STRING: ENSP00000330393
    A2MP010233, ENSP000003239294I2D: score=2 STRING: ENSP00000323929
    CRPP027413, ENSP000002550304I2D: score=1 STRING: ENSP00000255030
    About this table

    Gene Ontology (GO): 5/59 biological process terms (GO ID links to tree view) (see all 59):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001542ovulation from ovarian follicle IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001819positive regulation of cytokine production IEA--
    GO:0001890placenta development IDA17957153

    LEP for ontologies           About GeneDecksing

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LEP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for LEP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LEP (116-130) (mouse)Synthetic leptin peptide fragment[258276-95-8]

    1 HMDB Compound for LEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Androstenedione(4)-Androsten-3,17-dione (see all 14)63-05-811824514

    10/130 Novoseek inferred chemical compound relationships for LEP gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 84.8 1892 10411236 (8), 10411242 (8), 17170237 (7), 15814535 (6) (see all 99)
    c-peptide 71.5 169 12752073 (4), 16365005 (4), 19475640 (4), 15196417 (4) (see all 99)
    lipid 70.7 531 16737635 (6), 15543224 (5), 11502793 (5), 19169663 (4) (see all 99)
    testosterone 70.6 677 18462615 (11), 11244464 (9), 9253326 (7), 11228760 (6) (see all 99)
    cholesterol 70.4 648 15555610 (7), 16324751 (7), 11447020 (6), 17884293 (6) (see all 99)
    estradiol 67.6 321 9768648 (9), 11791088 (6), 9482922 (5), 11599235 (4) (see all 99)
    dehydroepiandrosterone sulfate 63.4 91 10561001 (3), 12647279 (3), 11820328 (2), 17198487 (2) (see all 52)
    orlistat 61.4 19 18846024 (3), 20119816 (2), 19409578 (2), 18457636 (1) (see all 6)
    fatty acid 61 162 16822822 (4), 11342529 (3), 11404229 (3), 15919610 (3) (see all 99)
    metformin 59.5 71 15531718 (6), 11436194 (4), 15983226 (3), 11289473 (3) (see all 37)

    2 PharmGKB related drug/compound annotations for LEP gene    About this table
    Drug/compound PharmGKB Annotation

    Search CenterWatch for drugs/clinical trials and news about LEP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LEP gene: 

    Unigene Cluster for LEP:

    Hs.194236  [show with all ESTs]
    Unigene Representative Sequence: NM_000230
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000308868(uc003vml.2 uc003vmm.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LEP
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate LEP (see all 24):
    hsa-miR-498 hsa-miR-29a hsa-miR-29c hsa-miR-128 hsa-miR-27b* hsa-miR-9 hsa-miR-1276 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidLEP 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LEP
    OriGene clones in human, mouse for LEP (see all 7)
    OriGene ORF clones in mouse, rat for LEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LEP (NM_000230)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEP
    Sirion Biotech Customized lentivirus for stable overexpression of LEP 
                         Customized lentivirus expression plasmids for stable overexpression of LEP 
    OriGene qPCR primer pairs and template standards for LEP
    OriGene qSTAR qPCR primer pairs in human, mouse for LEP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LEP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LEP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LEP

    Additional mRNA sequence: 

    AF008123.1 AK313553.1 BC060830.1 BC069323.1 BC069452.1 BC069527.1 D49487.1 U18915.1 

    1 DOTS entry:


    24/25 AceView cDNA sequences (see all 25):

    BQ012637 U18915 U43653 BC069527 BX098617 BC069323 BU752306 NM_000230 
    BC069452 R62951 BC060830 BX479630 AF008123 AA320865 R63003 BQ019411 
    CB995210 N56684 D49487 H42529 H39701 H42528 CB265926 CB995927 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LEP    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b

    ECgene alternative splicing isoforms for LEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LEP expression in normal human tissues (normalized intensities)      LEP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    LEP Expression
    About this image

    LEP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     Adipose (Muscoskeletal System)    fully expand to see all 17 entries
             Visceral White Adipocytes Visceral White Adipose
             Body Subcutaneous White Adipose
             omental adipose tissue   
             Human Hair Outer Root Sheath Cells (HHORSC)   
     Bone (Muscoskeletal System)
             Notch-transfected mesenchymal stromal cells (SB623)
     Mesenchymal Stem Cells
             Notch-transfected mesenchymal stromal cells (SB623)
     Dermis (Integumentary System)
             Human Hair Outer Root Sheath Cells (HHORSC)   

    See LEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LEP

    SOURCE GeneReport for Unigene cluster: Hs.194236
        SABiosciences Expression via Pathway-Focused PCR Arrays including LEP (see all 10): 
              Insulin Signaling Pathway in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Angiogenesis in human mouse rat

    OriGene qPCR primer pairs and template standards for LEP
    OriGene qSTAR qPCR primer pairs in human, mouse for LEP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LEP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LEP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LEP
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for LEP gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Lep1 , 5 leptin1, 5 82.63(n)1
      6 (12.30 cM)5
    168461  NM_008493.31  NP_032519.11 

    ENSEMBL Gene Tree for LEP (if available)
    TreeFam Gene Tree for LEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68)
    About This Section

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/616 SNPs in LEP are shown (see all 616)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 7 posSequence#AA
    CLeptin deficiency (LEPD)4 pathogenic1131237807(+) ACCTCC/TGGGAT 2 R W mis10--------
    C--127267454(-) TAATC-/TG/   
    1 -- int12NA 4
    C,F--127882006(+) AATGA-/AAT   
    1 -- int12NS 92
    C--127884139(+) AAAAAA/-GTAAC 1 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    C--127884300(+) CACAC-/ACAC  
    1 -- int10--------
    C--127884300(+) CCCTG-/ACACACAC
    1 -- int10--------
    C--127884300(+) CCCTG-/ACACAC
    1 -- int10--------
    --131222519(+) GAATGC/TCTATC 1 -- us2k10--------
    C,F,A,H--131222528(+) tcctaC/Tgcaat 1 -- us2k17Minor allele frequency- T:0.06EA NS NA WA 540
    C,F--131222529(+) CCTACG/ACAATG 1 -- us2k12Minor allele frequency- A:0.11WA 120

    HapMap Linkage Disequilibrium report for LEP (127881331 - 127897682 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LEP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33413CNV Gain17666407

    Human Gene Mutation Database (HGMD): LEP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LEP
    DNA2.0 Custom Variant and Variant Library Synthesis for LEP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164160    OMIM disorders: --

    UniProtKB/Swiss-Prot: LEP_HUMAN, P41159
  • Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe
    hyperphagia and intractable obesity from an early age. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 20/261 diseases for LEP (see all 261):    About MalaCards
    morbid obesity    leptin deficiency    diencephalic syndrome    monogenic non-syndromic obesity, autosomal recessive
    sleep apnea    overnutrition    nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency    lipoatrophic diabetes
    lipoblastoma    fetal macrosomia    acquired generalized lipodystrophy    obesity
    metabolic syndrome x    skin tag    alstrom syndrome    sick building syndrome
    anorexia nervosa    bulimia nervosa    hypogonadism    rabson-mendenhall syndrome

    20/23 diseases from the University of Copenhagen DISEASES database for LEP (see all 23):
    Diabetes mellitus     Hyperinsulinism     Morbid obesity     Hypertension
    Hyperglycemia     Lipodystrophy     Fatty liver disease     Polycystic ovary syndrome
    Atherosclerosis     Eating disorder     Amenorrhea     Hypogonadism
    Infertility     Heart disease     Osteoporosis     Kidney failure
    Prader-Willi syndrome     Breast cancer     Rabies     Hyperandrogenism

    LEP for disorders           About GeneDecksing

    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for LEP gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 93.7 2301 10722859 (6), 16782141 (6), 15793852 (6), 17147067 (5) (see all 99)
    insulin resistance 91.6 952 17093174 (6), 18521457 (5), 19781705 (5), 12485522 (5) (see all 99)
    insulin sensitivity 87.1 401 9876349 (8), 9385530 (5), 17413885 (4), 19269197 (4) (see all 99)
    hyperinsulinemia 79.1 151 17236585 (4), 9820061 (3), 17085442 (3), 15855322 (2) (see all 99)
    anorexia nervosa 78 154 17304762 (7), 11919545 (4), 9169091 (4), 9177394 (3) (see all 97)
    lipodystrophy 73.7 107 19727665 (5), 11856796 (4), 18348717 (4), 15356018 (3) (see all 51)
    polycystic ovary syndrome 72.9 112 11502810 (8), 12921548 (2), 17062953 (2), 18756827 (2) (see all 72)
    acquired generalized lipodystrophy 70.5 4 15256772 (1), 18076675 (1), 11994394 (1), 12502655 (1)
    lipodystrophy, congenital generalized 69.4 19 17118991 (4), 15983199 (3), 11994394 (2), 12502655 (2) (see all 12)
    niddm 68.3 128 2010535 (6), 8636448 (3), 9283801 (3), 8621021 (3) (see all 70)

    Genetic Association Database (GAD): LEP
    Human Genome Epidemiology (HuGE) Navigator: LEP (162 documents)

    Export disorders for LEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LEP gene, integrated from 9 sources (see all 4574) (see top 10):
    (articles sorted by number of sources associating them with LEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. (PubMed id 8621021)1, 2, 4, 9 Niki T.... Kasuga M. (1996)
    2. Genotype x nutrient association of common polymorphis ms in obesity-related genes with food preferences and time structure of energy intake. (PubMed id 19747414)1, 4, 9 BienertovA!-VaskA^ J....VaskA^ A. (2010)
    3. Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. (PubMed id 19697123)1, 4, 9 Cleveland R.J....Santella R.M. (2009)
    4. Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. (PubMed id 18564365)1, 4, 9 Han H....Park K. (2008)
    5. Leptin gene (TTTC)(n) microsatellite polymorphism as well as leptin receptor R223Q and PPARgamma2 P12A substitutions are not associa ted with hypertensive disorders in pregnancy. (PubMed id 20070288)1, 4, 9 Wiedemann A....Toth B. (2010)
    6. Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. (PubMed id 19337797)1, 4, 9 BienertovA!-VaskA^ J.A....VaskA^ A. (2009)
    7. Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins. (PubMed id 18490929)1, 4, 9 Souren N.Y....Zeegers M.P. (2008)
    8. Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. (PubMed id 18716353)1, 4, 9 Mizuta E....Morisaki T. (2008)
    9. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. (PubMed id 16504019)1, 4, 9 Snoussi K....Chouchane L. (2006)
    10. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. (PubMed id 15760495)1, 4, 9 Poitou C....Clement K. (2005)
    11. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. (PubMed id 15161768)1, 4, 9 Lakka T.A....Bouchard C. (2004)
    12. Congenital leptin deficiency is associated with severe early-onset obesity in humans. (PubMed id 9202122)1, 4, 9 Montague C.T....O'Rahilly S. (1997)
    13. Leptin gene -2548G/A variants predict risperidone-ass ociated weight gain in children and adolescents. (PubMed id 19873684)1, 4, 9 Calarge C.A....Schlechte J.A. (2009)
    14. Leptin gene (TTTC)(n) microsatellite polymorphism in pre-eclampsia and HELLP syndrome. (PubMed id 19634986)1, 4, 9 Nagy B....Rigo J. (2009)
    15. [The (-2548G/A) polymorphism of leptin gene in women with gestational hypertension and preeclampsia] (PubMed id 18624112)1, 4, 9 Drews K....Mrozikiewicz P.M. (2008)
    16. No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population. (PubMed id 18510797)1, 4, 9 Bienertova-Vasku J....Vasku A. (2008)
    17. Leptin and leptin receptor gene polymorphisms in obstructive sleep apnea syndrome. (PubMed id 17989154)1, 4, 9 Hanaoka M....Kubo K. (2008)
    18. Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophrenia. (PubMed id 17285096)1, 4, 9 Ellingrod V.L....Miller d.e.l. . . . . . . . . . . .D. (2007)
    19. Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. (PubMed id 17587397)1, 4, 9 Hart Sailors M.L....Bray M.S. (2007)
    20. Site -2548 of the leptin gene is associated with gender-specific trends in newborn size and cord leptin levels. (PubMed id 17852540)1, 4, 9 Adkins R.M....Morrison J.C. (2007)
    21. Association of leptin genetic polymorphism -2548 G/A with gestational diabetes mellitus. (PubMed id 18850205)1, 4, 9 Vasku J.A....Bienert P. (2006)
    22. Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease. (PubMed id 16261186)1, 4, 9 Porreca E....Stuppia L. (2006)
    23. Evaluation of leptin level and Ob gene polymorphism in patients with Behcet's disease. (PubMed id 16786343)1, 4, 9 Okudan N....Sari F. (2006)
    24. Leptin, soluble leptin receptor and leptin gene polymorphism in relation to preeclampsia risk. (PubMed id 15544427)1, 4, 9 Muy-Rivera M....Williams M.A. (2005)
    25. G(-2548)A leptin gene polymorphism in obese subjects is associated with serum leptin concentration and bone mass. (PubMed id 20502402)1, 4, 9 Franek E....Wiecek A. (2010)
    26. Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa populatio n of South Africa. (PubMed id 20140086)1, 4, 9 Okpechi I.G....Ramesar R. (2010)
    27. Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes? (PubMed id 18958929)1, 4, 9 Bienertova-Vasku J....Unzeitig V. (2008)
    28. Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes. (PubMed id 18681781)1, 4, 9 Srivastava V....Thelma B. (2008)
    29. Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. (PubMed id 18398047)1, 4, 9 Doecke J.D....Whiteman D.C. (2008)
    30. Are common leptin promoter polymorphisms associated with restenosis after coronary stenting? (PubMed id 17879022)1, 4, 9 Bienertova-Vasku J.A....Vasku A. (2007)
    31. Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. (PubMed id 17502770)1, 4, 9 Zhang X.Y....Kosten T.R. (2007)
    32. Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications. (PubMed id 16932309)1, 3, 9 Brennan A.M. and Mantzoros C.S. (2006)
    33. The LEP gene and age of menarche: maternal age as a potential cause of hidden stratification in association studies. (PubMed id 11461187)1, 4, 9 Comings D.E....MacMurray J.P. (2001)
    34. The A19G polymorphism in the 5' untranslated region of the human obese gene does not affect leptin levels in severely obese patients. (PubMed id 11061506)1, 4, 9 Lucantoni R....Di Blasio A.M. (2000)
    35. A leptin missense mutation associated with hypogonadism and morbid obesity. (PubMed id 9500540)1, 2, 9 Strobel A.... Strosberg A.D. (1998)
    36. Crystal structure of the obese protein leptin-E100. (PubMed id 9144295)1, 2, 9 Zhang F.... Schevitz R.W. (1997)
    37. Positional cloning of the mouse obese gene and its human homologue. (PubMed id 7984236)1, 2, 9 Zhang Y.... Friedman J.M. (1994)
    38. Association of HTR2C, but not LEP or INSIG2, genes wi th antipsychotic-induced weight gain in a German sample. (PubMed id 20504252)1, 4 Opgen-Rhein C....Dettling M. (2010)
    39. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (2010)
    40. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    41. Influence of polygenetic polymorphisms on the suscept ibility to non-alcoholic fatty liver disease of Chinese people. (PubMed id 20492333)1, 4 Zhou Y.J....Huang H.L. (2010)
    42. Family-based analysis of candidate genes for polycyst ic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (2010)
    43. [The influence of metabolic parameters on fetal devel opment weight in women with type 1 diabetes and homozygotic variant in -2548 G/ A of leptin gene and its 668 A/G receptor polymorphism]. (PubMed id 20873117)1, 4 Iciek R....Brazert J. (2010)
    44. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    45. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    46. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    47. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    48. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    49. Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. (PubMed id 20642810)1, 4 Friedlander Y....Siscovick D.S. (2010)
    50. Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals. (PubMed id 20520958)1, 4 Hinuy H.M....Hirata R.D. (2010)
    51. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1, 4 Larkin E.K....Redline S. (2010)
    52. Contrasting association of a non-synonymous leptin re ceptor gene polymorphism with Wegener's granulomatosis and Churg-Strauss syndro me. (PubMed id 20185531)1, 4 Wieczorek S....Epplen J.T. (2010)
    53. Association of -2548 G/A Polymorphism in the Leptin G ene with Preeclampsia/Pregnancy-Induced Hypertension. (PubMed id 20462372)1, 4 Sugathadasa B.H....Wijesundere A.P. (2010)
    54. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    55. Leptin G-2548A and leptin receptor Q223R gene polymor phisms are not associated with obesity in Romanian subjects. (PubMed id 19913498)1, 4 Constantin A....Popov D.L. (2010)
    56. Influence of the leptin G-2548A polymorphism on lepti n levels and anthropometric measurements in healthy Spanish adolescents. (PubMed id 20597904)1, 4 Riestra P....GarcAcs C. (2010)
    57. Association of the leptin gene with knee osteoarthrit is susceptibility in a Han Chinese population: a case-control study. (PubMed id 20664554)1, 4 Qin J....Jiang Q. (2010)
    58. Obesity and polycystic ovary syndrome: association wi th androgens, leptin and its genotypes. (PubMed id 20500101)1, 4 Pusalkar M....Maitra A. (2010)
    59. The Q223R polymorphism in LEPR is associated with obe sity in Pacific Islanders. (PubMed id 20183928)1, 4 Furusawa T....Ohashi J. (2010)
    60. Impact of leptin and leptin-receptor gene polymorphis ms on serum lipids in Japanese obese children. (PubMed id 20222875)1, 4 Okada T....Arisaka O. (2010)
    61. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    62. Genetic variation in adipokine genes and risk of colorectal cancer. (PubMed id 19273568)1, 4 Pechlivanis S....FAPrsti A. (2009)
    63. Association of common polymorphisms in IL10, and in o ther genes related to inflammatory response and obesity with colorectal cancer. (PubMed id 19760027)1, 4 Tsilidis K.K....Platz E.A. (2009)
    64. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    65. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    66. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    67. Leptin--2548 g/A polymorphism in endometrial cancer. (PubMed id 19886360)1, 4 Chovanec J....DostA!lovA! Z. (2009)
    68. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)
    69. Genetic variation in D7S1875 repeat polymorphism of leptin gene is associated with increased risk for depression: a case-control study from India. (PubMed id 19382181)1, 4 Kapoor M....Sidhu S. (2009)
    70. Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. (PubMed id 18992263)1, 4 Slattery M.L....Samowitz W.S. (2009)
    71. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (2009)
    72. Adipokine genes and prostate cancer risk. (PubMed id 19035456)1, 4 Moore S.C....Gunter M.J. (2009)
    73. Are genes associated with energy metabolism important in asthma and BMI? (PubMed id 19191138)1, 4 Szczepankiewicz A....Popiel A. (2009)
    74. Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. (PubMed id 19204185)1, 4 Ma D....Borecki I.B. (2009)
    75. Polymorphisms of the LEP- and LEPR gene and obesity in patients using antipsychotic medication. (PubMed id 19142102)1, 4 Gregoor J.G....Heerdink E.R. (2009)
    76. Association study between candidate genes and obesity-related phenotypes using a sample of lumberjacks. (PubMed id 19367093)1, 4 Chamberland A....Laprise C. (2009)
    77. Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche. (PubMed id 19506390)1, 4 Rothenbuhler A....Fradin D. (2009)
    78. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    79. No association between polymorphisms in LEP, LEPR, AD IPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. (PubMed id 19723917)1, 4 Teras L.R....Feigelson H.S. (2009)
    80. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. (PubMed id 19267370)1, 4 Wang M.H....Platz E.A. (2009)
    81. Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. (PubMed id 19077438)1, 4 Chung W.K....Tiwari H.K. (2009)
    82. Association of a common variant of the leptin gene with blood pressure in an obese Brazilian population. (PubMed id 19229195)1, 4 Genelhu V.A....Francischetti E.A. (2009)
    83. Genetic association study of selected candidate genes (ApoB, LPL, Leptin) and telomere length in obese and hypertensive individuals. (PubMed id 19772655)1, 4 Das B....Seshadri M. (2009)
    84. Pharmacogenetic contribution of leptin gene polymorphism in cutaneous T-cell lymphoma. (PubMed id 19079651)1, 4 Vasku V....Vasku J.B. (2009)
    85. Identification of leptin gene variants in school chil dren with early onset obesity. (PubMed id 20232565)1, 4 Kongmacheep P....Hancharoen K. (2009)
    86. Severe obesity is associated with novel single nucleo tide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese. (PubMed id 19491387)1, 4 Chen H.H....Pan W.H. (2009)
    87. Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer. (PubMed id 18855010)1, 4 Yapijakis C....Vairaktaris E. (2008)
    88. [-2548G/A functional polymorphism in the promoter region of leptin gene and antipsychotic agent-induced weight gain in schizophrenic patients: a study of nuclear family-based association] (PubMed id 18460775)1, 4 Mou X.D....Sun J. (2008)
    89. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (2008)
    90. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    91. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    92. Leptin gene, leptin gene receptor polymorphisms and body weight in pregnant women with type 1 diabetes mellitus. (PubMed id 18939509)1, 4 Iciek R....Pietryga M. (2008)
    93. Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses. (PubMed id 18828733)1, 4 Souren N.Y....Paulussen A.D. (2008)
    94. Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. (PubMed id 18059035)1, 4 Slattery M.L....Potter J.D. (2008)
    95. Leptin gene, leptin gene polymorphisms and body weight in pregnant women with diabetes mellitus type I. (PubMed id 18955751)1, 4 Iciek R....Brazert J. (2008)
    96. Genetic risk factors for renal failure among North Indian ESRD patients. (PubMed id 18242170)1, 4 Tripathi G....Agrawal S. (2008)
    97. Microsatellite polymorphism of the human leptin gene and risk of obesity. (PubMed id 18725053)1, 4 Gardezi A.Z....Marashi S.M. (2008)
    98. Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients. (PubMed id 19041299)1, 4 Ben Ali S....Kaabachi N. (2008)
    99. Possible association between the -2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain. (PubMed id 17804136)1, 4 Kang S.G....Kim L. (2008)
    100. The -2548G/A LEP polymorphism is associated with blood pressure in Tunisian obese patients. (PubMed id 18923972)1, 4 Ben Ali S....Kaabachi N. (2008)
    101. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    102. Lack of association between the G-2548A polymorphism of the leptin gene and psoriasis in a Turkish population. (PubMed id 18173522)1, 4 Kara N....Turanli A.Y. (2007)
    103. Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. (PubMed id 17192493)1, 4 de Krom M....Adan R. (2007)
    104. Contribution of several candidate gene polymorphisms in the determination of adiposity changes: results from the Quebec Family Study. (PubMed id 17299381)1, 4 Bouchard L....Perusse L. (2007)
    105. LEPR p.Q223R, beta3-AR p.W64R and LEP c.-2548G>A gene variants in obese Brazilian subjects. (PubMed id 18273796)1, 4 Duarte S.F....Pimentel M.M. (2007)
    106. Lack of association between leptin G2548A gene polymorphism and Behcet's disease. (PubMed id 17207170)1, 4 Aydin F....Turanli A.Y. (2007)
    107. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. (PubMed id 16571841)1, 4 Wang T.N....Ko Y.C. (2006)
    108. A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer. (PubMed id 16630717)1, 4 Ribeiro R....Medeiros R. (2006)
    109. Phenotypic variation in constitutional delay of growth and puberty: relationship to specific leptin and leptin receptor gene polymorphisms. (PubMed id 16793957)1, 4 Banerjee I....Clayton P.E. (2006)
    110. Lack of association between the tetranucleotide repeat polymorphism in the 3'-flanking region of the leptin gene and hypertension in severely obese patients. (PubMed id 17114907)1, 4 Maestrini S....Di Blasio A.M. (2006)
    111. Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Quebec Family Study. (PubMed id 16231024)1, 4 Loos R.J....Bouchard C. (2006)
    112. LEP 3'HVR is associated with obesity and leptin levels in Brazilian individuals. (PubMed id 16762576)1, 4 Hinuy H.M....Hirata R.D. (2006)
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    262. Interleukin-6 and human immunodeficiency virus load, but not plasma leptin concentration, predict anorexia and wasting in adults with pulmonary tuberculosis in Malawi. (PubMed id 15928249)1, 9 van Lettow M....Semba R.D. (2005)
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    264. Relationships of serum leptin levels with biochemical markers of bone turnover and with growth factors in normal weight and overweight children. (PubMed id 14726619)1, 9 Bini V....Falorni A. (2004)
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    266. Gender differences in tumor necrosis factor alpha and leptin secretion from subcutaneous and visceral fat tissue. (PubMed id 15479128)1, 9 Orel M....Hrebicek J. (2004)
    267. Serum concentrations of dehydroepiandrosterone sulfate and leptin in obese patients with normal serum cholesterol. (PubMed id 12647279)1, 9 Vierhapper H....Bieglmayer C. (2003)
    268. Changes in serum leptin in lean and obese subjects with acute hyperglycemic crises. (PubMed id 12788860)1, 9 Kitabchi A.E. and Umpierrez G.E. (2003)
    269. Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet. (PubMed id 12679442)1, 9 Weigle D.S....Purnell J.Q. (2003)
    270. The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance: negative correlation with anthropometric parameters of neonates in gestational diabetes. (PubMed id 12626032)1, 9 Cseh K....Winkler G. (2002)
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    275. Leptin expression correlates with favorable clinicopathologic phenotype and better prognosis in colorectal adenocarcinoma. (PubMed id 19050975)1, 9 Paik S.S....Jang S.J. (2009)
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    278. Insulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects. (PubMed id 19267279)1, 9 Ezenwaka C.E....Eckel J. (2009)
    279. The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease. (PubMed id 18839053)1, 9 Nar A. and Gedik O. (2009)
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    281. Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population. (PubMed id 19001191)1, 9 Welsh P....Sattar N. (2009)
    282. Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNFalpha involvement. (PubMed id 18308368)1, 9 Rafail S....Kartalis G. (2008)
    283. Rosiglitazone improves insulin sensitivity with increased serum leptin levels in patients with type 2 diabetes mellitus. (PubMed id 18394743)1, 9 Kim H.J....Cha B.S. (2008)
    284. Regulation of placental growth hormone secretion in a human trophoblast model--the effects of hormones and adipokines. (PubMed id 18356738)1, 9 Zeck W....Russell A. (2008)
    285. Association of plasma leptin levels and complexity of the culprit lesion in patients with unstable angina. (PubMed id 17482294)1, 9 Dubey L....Tao H. (2008)
    286. Apolipoprotein J and leptin levels in patients with coronary heart disease. (PubMed id 18712185)1, 9 Poulakou M.V....Perrea D. (2008)
    287. Growth hormone, insulin-like growth factor I, and leptin interaction in human cultured lutein granulosa cells steroidogenesis. (PubMed id 18082739)1, 9 Karamouti M....Messinis I.E. (2008)
    288. Association between prostate-specific antigen and leptin, adiponectin, HbA1c or C-peptide among African-American and Caucasian men. (PubMed id 17938644)1, 9 Fowke J.H....Blot W.J. (2008)
    289. The influence of increased training volume on cytokines and ghrelin concentration in college level male rowers. (PubMed id 18665387)1, 9 Ramson R....Maestu J. (2008)
    290. Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients. (PubMed id 16764962)1, 9 Yanagawa T....Seino Y. (2007)
    291. Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus. (PubMed id 17445536)1, 9 Tamura T....Kohno N. (2007)
    292. The impact of hyperactivity and leptin on recovery from anorexia nervosa. (PubMed id 17530161)1, 9 van Elburg A.A....van Engeland H. (2007)
    293. Leptin and coronary heart disease risk: prospective case control study of British women. (PubMed id 17636087)1, 9 Lawlor D.A....Ebrahim S. (2007)
    294. Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome. (PubMed id 17573060)1, 9 Hallikainen M....Gylling H. (2007)
    295. Relationship between leptin concentration and insulin resistance. (PubMed id 18075970)1, 9 Maghbooli Z....Larijani B. (2007)
    296. Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome. (PubMed id 17895321)1, 9 Li M.G....Huang H.F. (2007)
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    298. Progesterone and human placental lactogen inhibit leptin secretion on cultured trophoblast cells from human placentas at term. (PubMed id 16048798)1, 9 Coya R....Senaris R. (2005)
    299. Leptin down-regulates peroxisome proliferator-activated receptor gamma (PPAR-gamma) mRNA levels in primary human monocyte-derived macrophages. (PubMed id 16335797)1, 9 Cabrero A....Vazquez-Carrera M. (2005)
    300. Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. (PubMed id 15803114)1, 9 Valle M....Morales R. (2005)
    301. Leptin and leptin receptor expression in the myometrium and uterine myomas: Is leptin involved in tumor development? (PubMed id 16273205)1, 9 Markowska A....Malendowicz L.K. (2005)
    302. Leptin directly controls secretory activity of human ovarian granulosa cells: possible inter-relationship with the IGF/IGFBP system. (PubMed id 16244494)1, 9 Sirotkin A.V....Hetenyi L. (2005)
    303. [Serum resistin and leptin in patients with chronic obstructive pulmonary disease and their relationship to nutritional state] (PubMed id 16115391)1, 9 Wang Q.Y....Yu R.J. (2005)
    304. Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. (PubMed id 14985328)1, 9 Catalano S....Ando S. (2004)
    305. High ascitic fluid leptin levels in patients with decompensated liver cirrhosis and sterile ascites: relationship with TNF-alpha levels. (PubMed id 15104370)1, 9 Giannini E....Testa R. (2004)
    306. Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome. (PubMed id 15533361)1, 9 Erturk E....Imamoglu S. (2004)
    307. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. (PubMed id 15292320)1, 9 Reilly M.P....Kimmel S.E. (2004)
    308. Ghrelin/Leptin-imbalance in patients with primary biliary cirrhosis. (PubMed id 15052530)1, 9 Breidert M....Brabant G. (2004)
    309. Leptin concentrations in maternal serum and cord blood in diabetic and nondiabetic pregnancy. (PubMed id 12748507)1, 9 Manderson J.G....McCance D.R. (2003)
    310. Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. (PubMed id 12734209)1, 9 Catalano S....Ando S. (2003)
    311. Leptin levels in type 2 diabetes: associations with measures of insulin resistance and insulin secretion. (PubMed id 12734788)1, 9 Wauters M....Van Gaal L.F. (2003)
    312. Relationship of leptin and sex hormones to bone mineral density in men. (PubMed id 14618446)1, 9 Sun A.J....Phillips G.B. (2003)
    313. Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. (PubMed id 11997182)1, 9 Bruun J.M....Richelsen B. (2002)
    314. Is leptin the link between fat and bone mass? (PubMed id 12211425)1, 9 Thomas T. and Burguera B. (2002)
    315. Leptin and metabolic syndrome in obese and non-obese children. (PubMed id 12189588)1, 9 Moreno L.A....Bueno M. (2002)
    316. Up-regulation of vascular endothelial growth factor and down-regulation of pigment epithelium-derived factor messenger ribonucleic acid levels in leptin-exposed cultured retinal pericytes. (PubMed id 12779248)1, 9 Yamagishi S....Takeuchi M. (2002)
    317. Plasma leptin and leptin receptor expression in childhood acute lymphoblastic leukemia. (PubMed id 12512839)1, 9 Wex H....Vorwerk P. (2002)
    318. Comparison of PGE2, prostacyclin and leptin release by human adipocytes versus explants of adipose tissue in primary culture. (PubMed id 12468269)1, 9 Fain J.N....Leffler C.W. (2002)
    319. Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus. (PubMed id 12218380)1, 9 Simon I....Richart C. (2002)
    320. Serum leptin and leptin binding activity in children and adolescents with hypothalamic dysfunction. (PubMed id 12199340)1, 9 Patel L....Clayton P.E. (2002)
    321. Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence. (PubMed id 12364439)1, 9 Kratzsch J....Kiess W. (2002)
    322. Spontaneous nocturnal leptin secretion in children with myelomeningocele and growth hormone deficiency. (PubMed id 12218376)1, 9 Trollmann R....Dotsch J. (2002)
    323. Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation. (PubMed id 11994543)1, 9 Wu M.H....Tsai S.J. (2002)
    324. Familial obesity, sympathetic activation and blood pressure level. (PubMed id 11800057)1, 9 Masuo K....Tuck M.L. (2001)
    325. Are ghrelin and leptin involved in food intake and bo dy mass index in maintenance hemodialysis? (PubMed id 19913442)1, 9 Mafra D....Fouque D. (2010)
    326. Leptin, adiponectin, their ratio and risk of Coronary Heart Disease: results from the MONICA/KORA Augsburg Study 1984-2002. (PubMed id 19732895)1, 9 Karakas M....Thorand B. (2010)
    327. Apical leptin induces chloride secretion by intestina l epithelial cells and in a rat model of acute chemotherapy-induced colitis. (PubMed id 20203064)1, 9 Hoda M.R....Barrett K.E. (2010)
    328. Interrelationships of Factor VII activity and plasma leptin with insulin resistance in coronary heart disease. (PubMed id 19781705)1, 9 Karatela R.A. and Sainani G.S. (2010)
    329. Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study. (PubMed id 20019673)1, 9 Asferg C....Jeppesen J. (2010)
    330. Expression of estrogen receptor alpha increases lepti n-induced STAT3 activity in breast cancer cells. (PubMed id 19876927)1, 9 Binai N.A....Wessler S. (2010)
    331. Maintenance of naA^ve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3. (PubMed id 19941883)1, 9 Chen J....Mountz J.D. (2010)
    332. Relation between first trimester maternal serum lepti n levels and body mass index in normotensive and pre-eclamptic pregnancies--rol e of leptin as a marker of pre-eclampsia: a prospective case-control study. (PubMed id 20050765)1, 9 Samolis S....Maroulis G. (2010)
    333. Serum leptin level in geriatric patients with hip fractures: possible correlation to biochemical parameters of bone remodeling. (PubMed id 18359113)1, 9 Shabat S....Kestanbaum-Shainkin R. (2009)
    334. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. (PubMed id 19429119)1, 9 Greco S.J....Tezapsidis N. (2009)
    335. Obesity and the associated mediators leptin, estrogen and IGF-I enhance the cell proliferation and early tumorigenesis of breast can cer cells. (PubMed id 19838920)1, 9 Lautenbach A....Nave H. (2009)
    336. Characteristics associated with fasting appetite hormones (obestatin, ghrelin, and leptin). (PubMed id 19057526)1, 9 Beasley J.M....Appel L.J. (2009)
    337. Interleukin-6 and leptin as markers of energy metabol icchanges in advanced ovarian cancer patients. (PubMed id 18624749)1, 9 MacciA^ A....Mantovani G. (2009)
    338. Bone mineral density and bone turnover in relation to serum leptin, alpha-ketoglutarate and sex steroids in overweight and obese postmenopausal women. (PubMed id 18547340)1, 9 Filip R. and Raszewski G. (2009)
    339. Up-regulation of placental leptin by human chorionic gonadotropin. (PubMed id 18787032)1, 9 MaymA^ J.L....Varone C.L. (2009)
    340. Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway. (PubMed id 19250936)1, 9 Mattioli B....Viora M. (2009)
    341. Serum leptin in overt and subclinical hypothyroidism: effect of levothyroxine treatment and relationship to menopausal status and body composition. (PubMed id 19415994)1, 9 Teixeira P.F....Vaisman M. (2009)
    342. Leptin-signaling inhibition results in efficient anti -tumor activity in estrogen receptor positive or negative breast cancer. (PubMed id 19531256)1, 9 Rene Gonzalez R....Penichet M.L. (2009)
    343. High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus. (PubMed id 18505467)1, 9 Dullaart R.P....Voorbij H.A. (2009)
    344. Serum leptin levels correlate with clinical and biochemical indices of insulin resistance in women with polycystic ovary syndrome. (PubMed id 19340711)1, 9 Pehlivanov B. and Mitkov M. (2009)
    345. Circulating leptin and bone mineral density in rheumatoid arthritis. (PubMed id 19208597)1, 9 Aguilar-Chavez E.A....Gonzalez-Lopez L. (2009)
    346. Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity. (PubMed id 19132239)1, 9 Dellas C....Konstantinides S. (2008)
    347. Leptin signaling in breast cancer: an overview. (PubMed id 18821585)1, 9 Cirillo D....Normanno N. (2008)
    348. The role of leptin and orexins in the dysfunction of hypothalamo-pituitary-gonadal regulation and in the mechanism of hyperactivity in patients with anorexia nervosa. (PubMed id 18283238)1, 9 Baranowska B....Martynska L. (2008)
    349. Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers. (PubMed id 18404969)1, 9 Vela-Huerta M.M....Hernnandez J. (2008)
    350. Potential role of adipocytokine leptin in acute coronary syndrome. (PubMed id 18381870)1, 9 Dubey L....Liu R.Y. (2008)
    351. Leptin in nonalcoholic fatty liver disease. (PubMed id 18753993)1, 9 Canbakan B....Senturk H. (2008)
    352. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. (PubMed id 18356846)1, 9 Sheu W.H....Lee I.T. (2008)
    353. Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction. (PubMed id 18466078)1, 9 Braclik M....Orzel/ A. (2008)
    354. Increased adipogenesis of osteoporotic human-mesenchymal stem cells (MSCs) characterizes by impaired leptin action. (PubMed id 17973271)1, 9 Astudillo P....Rodriguez J.P. (2008)
    355. Analysis of plasma adipocytokines related to clinical and laboratory data in the maintenance hemodialysis patients. (PubMed id 18670142)1, 9 Okano K....Kabaya T. (2008)
    356. Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway. (PubMed id 18619412)1, 9 Perez-Perez A....Sanchez-Margalet V. (2008)
    357. Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis. (PubMed id 18349107)1, 9 Galluccio E....Monti L.D. (2008)
    358. Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea. (PubMed id 18365276)1, 9 Kapsimalis F....Gourgoulianis K. (2008)
    359. Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. (PubMed id 18473416)1, 9 Huang X.D....Zhan X.Y. (2008)
    360. Circulating leptin and angiogenic factors in preeclampsia patients. (PubMed id 18490835)1, 9 Nakatsukasa H....Hiramatsu Y. (2008)
    361. Regulation of leptin, adiponectin and acylation-stimulating protein by hyperinsulinaemia and hyperglycaemia in vivo in healthy lean young men. (PubMed id 18562232)1, 9 Faraj M....Rabasa-Lhoret R. (2008)
    362. Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population. (PubMed id 18716356)1, 9 Masuo K....Esler M.D. (2008)
    363. Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. (PubMed id 18316358)1, 9 Do R....Engert J.C. (2008)
    364. The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. (PubMed id 16912864)1, 9 Ogunwobi O.O. and Beales I.L. (2007)
    365. Serum leptin in rheumatoid arthritis. (PubMed id 17443329)1, 9 Wisl/owska M....Cicha M. (2007)
    366. Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study. (PubMed id 18000615)1, 9 Martinez-Calatrava M.J....Serrano-Rios M. (2007)
    367. Leptin modulates the expression of secreted and membrane-associated mucins in colonic epithelial cells by targeting PKC, PI3K, and MAPK pathways. (PubMed id 17495032)1, 9 El Homsi M....Plaisancie P. (2007)
    368. Circulating leptin levels are not influenced by thyroid status in hypothyroid and euthyroid women. (PubMed id 17693966)1, 9 Owecki M....Sowinski J. (2007)
    369. Leptin promotes cell proliferation and survival of trophoblastic cells. (PubMed id 17021346)1, 9 MagariA+os M.P....Varone C.L. (2007)
    370. High altitude induced anorexia: effect of changes in leptin and oxidative stress levels. (PubMed id 18284032)1, 9 Vats P....Singh S.B. (2007)
    371. Serum leptin level in women with unexplained infertility. (PubMed id 17485120)1, 9 Demir B....Gul T. (2007)
    372. Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa. (PubMed id 17558893)1, 9 Munoz-Calvo la Piedra C. (2007)
    373. Altered postprandial glucose, insulin, leptin, and ghrelin in liver cirrhosis: correlations with energy intake and resting energy expenditure. (PubMed id 17344504)1, 9 Kalaitzakis E....Bjornsson E. (2007)
    374. Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. (PubMed id 17728393)1, 9 Gruen M.L....Hasty A.H. (2007)
    375. Leptin measurement in urine is a reliable method of monitoring its secretion in patients with obstructive sleep apnea syndrome. (PubMed id 18204121)1, 9 Chorostowska-Wynimko J....Gorecka D. (2007)
    376. Telmisartan reduced blood pressure and HOMA-IR with increasing plasma leptin level in hypertensive and type 2 diabetic patients. (PubMed id 17240472)1, 9 Usui I....Kobayashi M. (2007)
    377. Circulating leptin and osteoprotegerin levels affect insulin resistance in healthy premenopausal obese women. (PubMed id 17923273)1, 9 Ugur-Altun B. and Altun A. (2007)
    378. Mechanistic roles of leptin in osteogenic stimulation in thoracic ligament flavum cells. (PubMed id 17702747)1, 9 Fan D....Shang Y. (2007)
    379. Sex steroids and leptin regulate 11beta-hydroxysteroid dehydrogenase I and P450 aromatase expressions in human preadipocytes: Sex specificities. (PubMed id 16621515)1, 9 Dieudonne M.N....Pecquery R. (2006)
    380. Leptin increases proliferation of human steosarcoma cells through activation of PI(3)-K and MAPK pathways. (PubMed id 17072262)1, 9 Burguera B....Zhao A. (2006)
    381. Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population. (PubMed id 17016694)1, 9 Jamshidi Y....O'Dell S.D. (2006)
    382. Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway. (PubMed id 17054914)1, 9 Uotani S....Yamaguchi Y. (2006)
    383. Leptin predicts BMD and bone resorption in older women but not older men: the Rancho Bernardo study. (PubMed id 16734391)1, 9 Weiss L.A....Clark P. (2006)
    384. Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in children. (PubMed id 17679810)1, 9 Kelly A.S....Dengel D.R. (2006)
    385. Long-term efficacy of leptin replacement in patients with generalized lipodystrophy. (PubMed id 15983199)1, 9 Javor E.D....Gorden P. (2005)
    386. The relation of serum and follicular fluid leptin and ovarian steroid levels in response to induction of ovulation in in vitro fertilization cycles. (PubMed id 15653206)1, 9 Gurbuz B....Tasdemir S. (2005)
    387. Correlations between leptin, body composition, bone mineral density, and bone metabolism in kidney transplant recipients. (PubMed id 15964364)1, 9 Malyszko J....Mysliwiec M. (2005)
    388. TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patients. (PubMed id 15863950)1, 9 Oge A....Demir S. (2005)
    389. Peripheral total and differential leukocyte count in diabetic nephropathy: the relationship of plasma leptin to leukocytosis. (PubMed id 15983324)1, 9 Chung F.M....Lee Y.J. (2005)
    390. Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex. (PubMed id 15886225)1, 9 Elbatarny H.S. and Maurice D.H. (2005)
    391. Follicular fluid levels of vascular endothelial growth factor and leptin are associated with pregnancy outcome of normal women participating in intracytoplasmic sperm injection cycles. (PubMed id 15588162)1, 9 Asimakopoulos B....Diedrich K. (2005)
    392. Leptin secretion by human ejaculated spermatozoa. (PubMed id 15944217)1, 9 Aquila S....Ando S. (2005)
    393. A twin study for serum leptin, soluble leptin receptor, and free insulin-like growth factor-I in pubertal females. (PubMed id 15784711)1, 9 Li H.J....Hu Y.H. (2005)
    394. Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents. (PubMed id 15811876)1, 9 Misra M....Klibanski A. (2005)
    395. Leptin, adiponectin, and ghrelin dysregulation in chronic kidney disease. (PubMed id 15648019)1, 9 Guebre-Egziabher F....Fouque D. (2005)
    396. Serum leptin concentration and anaerobic performance do not change during the menstrual cycle of young females. (PubMed id 16136023)1, 9 Okudan N....Baltaci A. (2005)
    397. Hormone and metabolic factors associated with leptin mRNA expression in pre- and postmenopausal women. (PubMed id 15219792)1, 9 Fajardo M.E....Barrera-Saldana H.A. (2004)
    398. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. (PubMed id 15232612)1, 9 Dixit V.D....Taub D.D. (2004)
    399. The formation of an intrachain disulfide bond in the leptin protein is necessary for efficient leptin secretion. (PubMed id 15358050)1, 9 Boute N....Issad T. (2004)
    400. Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function. (PubMed id 14722031)1, 9 Eikelis N....Esler M. (2004)
    401. Antiapoptotic effects of leptin in human neuroblastoma cells. (PubMed id 15166121)1, 9 Russo V.C....Werther G.A. (2004)
    402. The role of leptin in regulating neuroendocrine function in humans. (PubMed id 15333744)1, 9 Bluher S. and Mantzoros C.S. (2004)
    403. Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma. (PubMed id 15300888)1, 9 Wang X.J....Wang W.D. (2004)
    404. Serum leptin level is a regulator of bone mass. (PubMed id 14978271)1, 9 Elefteriou F....Karsenty G. (2004)
    405. Is leptin associated with serum lipid profile or any other parameters of blood biochemistry in post-menopausal women with osteoporosis? (PubMed id 15307204)1, 9 Oguz S....Mollamahmutoglu L. (2004)
    406. Leptin regulates functional capacities of polymorphonuclear neutrophils. (PubMed id 14567439)1, 9 Caldefie-Chezet F....Vasson M.P. (2003)
    407. Leptin, ghrelin, and proinflammatory cytokines: compounds with nutritional impact in chronic kidney disease? (PubMed id 14681862)1, 9 Stenvinkel P....Lindholm B. (2003)
    408. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. (PubMed id 12679465)1, 9 Yannakoulia M....Mantzoros C.S. (2003)
    409. Growth hormone-insulin-like growth factor-1 axis, leptin and sleep in anorexia nervosa patients. (PubMed id 12707489)1, 9 Lindberg N....Porkka-Heiskanen T. (2003)
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    448. Effects of PPARg agonists on the expression of leptin and vascular endothelial growth factor in breast cancer cells. (PubMed id 23254958)1 Terrasi M....Russo A. (2013)
    449. Ghrelin, leptin and insulin in cirrhotic children and adolescents: relationship with cirrhosis severity and nutritional status. (PubMed id 23142314)1 Dornelles C.T....Silveira T.R. (2013)
    450. Elevated serum leptin levels in nonobese patients with psoriasis. (PubMed id 23377401)1 Aly D.G....Hafiz N.A. (2013)
    451. Transcriptional patterns in peritoneal tissue of encap sulating peritoneal sclerosis, a complication of chronic peritoneal dialysis. (PubMed id 23418565)1 Reimold F.R....Alper S.L. (2013)
    452. Obesity-associated adipokines correlate with survival in epithelial ovarian cancer. (PubMed id 23402904)1 Diaz E.S....Li A.J. (2013)
    453. Association between serum leptin concentrations and in sulin resistance: a population-based study from China. (PubMed id 23349940)1 Zuo H....Hussain A. (2013)
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    455. Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients. (PubMed id 23529020)1 Li R....Li S. (2013)
    456. Experimental hyperleptinemia acutely increases vasocon strictory sympathetic nerve activity in healthy humans. (PubMed id 23393176)1 Machleidt F....Sayk F. (2013)
    457. Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X. (PubMed id 23066861)1 Liao Y.C....Sheu W.H. (2013)
    458. Serum bile acids and leptin interact with glucose meta bolism in patients with liver cirrhosis. (PubMed id 22770668)1 Valentini L....Ockenga J. (2013)
    459. The tetrad BMI, leptin, leptin/adiponectin (L/A) ratio and CA 15-3 are reliable biomarkers of breast cancer. (PubMed id 23292756)1 Santillan-Benitez J.G....Ordonez-Quiroz A. (2013)
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    462. High-circulating leptin levels are associated with inc reased blood pressure in uncontrolled resistant hypertension. (PubMed id 22810172)1 de Haro Moraes C....Junior H.M. (2013)
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    466. Association with leptin gene C.-2548 G>A polymorphi sm, serum leptin levels, and body mass index in Turkish obese patients. (PubMed id 23054910)1 Sahin D.S....Gunesacar R. (2013)
    467. The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation. (PubMed id 23262295)1 Xu X....Kong B. (2013)
    468. Folic acid uptake by the human syncytiotrophoblast is affected by gestational diabetes, hyperleptinemia, and TNF-a. (PubMed id 23338599)1 Araujo J.R....Keating E. (2013)
    469. Locally applied leptin induces regional aortic wall de generation preceding aneurysm formation in apolipoprotein E-deficient mice. (PubMed id 23220275)1 Tao M....Schneiderman J. (2013)
    470. Up-regulated expression and aberrant DNA methylation o f LEP and SH3PXD2A in pre-eclampsia. (PubMed id 23544093)1 Xiang Y....Zhao X. (2013)
    471. Hypomethylation of the LEP gene in placenta and elevat ed maternal leptin concentration in early onset pre-eclampsia. (PubMed id 23274423)1 Hogg K....Robinson W.P. (2013)
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    473. T cell-derived leptin contributes to increased frequen cy of T helper type 17 cells in female patients with Hashimoto's thyroiditis. (PubMed id 23199324)1 Wang S....Lu L. (2013)
    474. Expression of adiponectin, leptin, and their receptors in ovarian endometrioma. (PubMed id 23579009)1 Choi Y.S....Choi J.H. (2013)
    475. Non-hodgkin lymphoma and circulating markers of inflam mation and adiposity in a nested case-control study: the multiethnic cohort. (PubMed id 23300021)1 Conroy S.M....Kolonel L.N. (2013)
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    477. Effects of intense cycling training on plasma leptin a nd adiponectin and its relation to insulin resistance. (PubMed id 23685422)1 Lakhdar N....Bouassida A. (2013)
    478. Osteoprotegerin, leptin and IL-6: association with sil ent myocardial ischemia in type 2 diabetes mellitus. (PubMed id 22496403)1 Guzel S....Celebi A. (2013)
    479. Physical activity attenuates the negative effect of lo w birth weight on leptin levels in European adolescents; the HELENA study. (PubMed id 22397877)1 Labayen I....Ruiz J.R. (2013)
    480. Adiposity, adipokines, and risk of incident stroke in older men. (PubMed id 23192755)1 Wannamethee S.G....Sattar N. (2013)
    481. The role of leptin on the organization and expression of cytoskeleton elements in nucleus pulposus cells. (PubMed id 23335226)1 Li Z....Liu J. (2013)
    482. Neuroendocrine alterations in the exercising human: im plications for energy homeostasis. (PubMed id 23415825)1 Fuqua J.S. and Rogol A.D. (2013)
    483. Leptin modulates dose-dependently the metabolic and cy tolytic activities of NK-92 cells. (PubMed id 23129404)1 Lamas B....Farges M.C. (2013)
    484. Leptin attenuates the anti-estrogen effect of tamoxife n in breast cancer. (PubMed id 23199901)1 Chen X....Yin Y. (2013)
    485. Leptin levels in exhaled breath condensate from asthma tic children: a pilot study. (PubMed id 22107135)1 Inci D....Moeller A. (2012)
    486. Serum leptin, resistin, visfatin and adiponectin level s in tumor necrosis factor receptor-associated periodic syndrome (TRAPS). (PubMed id 22935190)1 Cantarini L....Fioravanti A. (2012)
    487. Leptin and HER-2 are associated with gastric cancer pr ogression and prognosis of patients. (PubMed id 22883999)1 Geng Y....Yin Y. (2012)
    488. Leptin mediates tumor-stromal interactions that promot e the invasive growth of breast cancer cells. (PubMed id 22282662)1 Barone I....Ando S. (2012)
    489. Circulating levels of adiponectin, leptin, fetuin-A an d retinol-binding protein in patients with tuberculosis: markers of metabolism a nd inflammation. (PubMed id 22685600)1 Keicho N....Lien L.T. (2012)
    490. The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non- obese premenopausal women. (PubMed id 22981830)1 Zhao H.Y....Liu J.M. (2012)
    491. Leptin and peroxisome proliferator-activated receptor g expression in colorectal adenoma. (PubMed id 22363123)1 Kim H.H....Moon J.S. (2012)
    492. The effect of sleep apnea and insomnia on blood levels of leptin, insulin resistance, IP-10, and hydrogen sulfide in type 2 diabetic p atients. (PubMed id 22746298)1 Jain S.K....Levine S.N. (2012)
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    494. Association between adipocytokines and insulin resista nce in Indian hypertensive patients. (PubMed id 22572423)1 Mahadik S.R. (2012)
    495. Leptin promoter G-2548A genotypes and associated serum leptin levels in childhood acute leukemia at diagnosis and under high-dose ster oid therapy. (PubMed id 21955253)1 Tavil B....Gurgey A. (2012)
    496. Effects of estradiol and FSH on leptin levels in women with suppressed pituitary. (PubMed id 22703959)1 Geber S....Sampaio M. (2012)
    497. Effect of three common SNPs in 5'-flanking region of L EP and ADIPOQ genes on their expression in Polish obese children and adolescents . (PubMed id 21755292)1 Cieslak J....Switonski M. (2012)
    498. Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis. (PubMed id 21848410)1 Malhotra N....Kumar S. (2012)
    499. Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin II in cultured human coronary artery smooth muscle cells. (PubMed id 21806545)1 Shyu K.G....Hung H.F. (2012)
    500. Evaluation of serum adipokines in peripheral arterial occlusive disease. (PubMed id 22547903)1 Gherman C.D. and Mironiuc A.I. (2012)
    501. Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy. (PubMed id 22364914)1 Veloso S....Vidal F. (2012)
    502. Leptin regulates dopamine responses to sustained stres s in humans. (PubMed id 23115175)1 Burghardt P.R....Zubieta J.K. (2012)
    503. Expression and release of leptin and proinflammatory c ytokines in patients with ulcerative colitis and infectious diarrhea. (PubMed id 23211301)1 Biesiada G....Mach T. (2012)
    504. Leptin-induced epithelial-mesenchymal transition in br east cancer cells requires b-catenin activation via Akt/GSK3- and MTA1/Wnt1 prot ein-dependent pathways. (PubMed id 22270359)1 Yan D....Sharma D. (2012)
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    507. Alveolar macrophages from overweight/obese subjects wi th asthma demonstrate a proinflammatory phenotype. (PubMed id 22773729)1 Lugogo N.L....Kraft M. (2012)
    508. Inflammatory markers and metabolic syndrome among adol escents. (PubMed id 22909576)1 Gonzalez M....Tur J.A. (2012)
    509. Hyperleptinemia is associated with hypertension, syste mic inflammation and insulin resistance in overweight but not in normal weight m en. (PubMed id 21920718)1 Galletti F....Strazzullo P. (2012)
    510. Normal leptin expression, lower adipogenic ability, de creased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic S coliosis. (PubMed id 22615788)1 Liang G....Huang D. (2012)
    511. [Correlation between local microenvironment leptin exp ression and avascular necrosis of the femoral head]. (PubMed id 23230665)1 Liu T....Hai Y. (2012)
    512. Leptin and regulatory T-lymphocytes in idiopathic pulm onary arterial hypertension. (PubMed id 22362850)1 Huertas A....Humbert M. (2012)
    513. Involvement of adipokines, AMPK, PI3K and the PPAR sig naling pathways in ovarian follicle development and cancer. (PubMed id 23417417)1 Dupont J....Rame C. (2012)
    514. Reactive leptin resistance and the profile of platelet activation in acute ischaemic stroke patients. (PubMed id 22627503)1 Lukasik M....Kozubski W. (2012)
    515. Relationship of adiponectin and leptin to coronary art ery disease, classical cardiovascular risk factors and atherothrombotic biomarke rs in the IARS cohort. (PubMed id 22955445)1 Shanker J....Kakkar V.V. (2012)
    516. Central obesity, leptin and cognitive decline: the Sac ramento Area Latino Study on Aging. (PubMed id 22814127)1 Zeki Al Hazzouri A....Neuhaus J. (2012)
    517. Sex difference and the role of leptin in the associati on between high-sensitivity C-reactive protein and adiposity in two different po pulations. (PubMed id 22392590)1 Rossi I.A....Taffe P. (2012)
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    519. Evaluation of leptin levels among fibromyalgia patient s before and after three months of treatment, in comparison with healthy control s. (PubMed id 22518370)1 Ablin J.N....Levartovsky D. (2012)
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    521. Association study of polymorphisms in leptin and lepti n receptor genes with antipsychotic-induced body weight gain. (PubMed id 22426215)1 Brandl E.J....Puls I. (2012)
    522. Circulatory and adipose tissue leptin and adiponectin in relationship to resting energy expenditure in patients with chronic obstructi ve pulmonary disease. (PubMed id 22881231)1 Brusik M....Tkacova R. (2012)
    523. Relationship between adipokines and coronary artery an eurysm in children with Kawasaki disease. (PubMed id 22683371)1 Liu R....Yi Q. (2012)
    524. Adiponectin and leptin induce VCAM-1 expression in hum an and murine chondrocytes. (PubMed id 23285079)1 Conde J....Gualillo O. (2012)
    525. Adiponectin and leptin systems in human endometrium du ring window of implantation. (PubMed id 22265003)1 Dos Santos E....Dieudonne M.N. (2012)
    526. Leptin, leptin gene and leptin receptor gene polymorph ism in heart failure with preserved ejection fraction. (PubMed id 21584748)1 Abd El-Aziz T.A....Pasha H.F. (2012)
    527. Cytokine profile, metabolic syndrome and cardiovascula r disease risk in women with late-onset gestational diabetes mellitus. (PubMed id 22200508)1 Lopez-Tinoco C....Bartha J.L. (2012)
    528. Serum adiponectin, resistin, leptin concentration and central adiposity parameters in Barrett's esophagus patients with and without in testinal metaplasia in comparison to healthy controls and patients with GERD. (PubMed id 22944288)1 Mokrowiecka A....Malecka-Panas E. (2012)
    529. Induction of insulin resistance by the adipokines resi stin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes. (PubMed id 22491740)1 Gerrits A.J....Akkerman J.W. (2012)
    530. Association between umbilical cord leptin and weight g ain according to feeding type in the early postnatal period, a brief report. (PubMed id 23593779)1 Trevino-Garza C....Argente J. (2012)
    531. Leptin and adiponectin: distribution and associations with cardiovascular risk factors in men and women of the general population. (PubMed id 22508240)1 Andreasson A.N....Brismar K. (2012)
    532. Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian vo lunteers. (PubMed id 22734460)1 Boumaiza I....Bouslama A. (2012)
    533. Human skeletal muscle releases leptin in vivo. (PubMed id 23010500)1 Wolsk E....van Hall G. (2012)
    534. Polymorphisms in the 3'UTR of the human leptin gene an d their role in hypertension. (PubMed id 22218754)1 Akhter Q....Ganai B.A. (2012)
    535. Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resista nce training. (PubMed id 22975643)1 Walsh S....Pescatello L.S. (2012)
    536. Association between leptin and its soluble receptor wi th cardiometabolic risk factors in a Brazilian population. (PubMed id 22863437)1 Martins C.J....Francischetti E.A. (2012)
    537. Leptin locally synthesized in carotid atherosclerotic plaques could be associated with lesion instability and cerebral emboli. (PubMed id 23316287)1 Schneiderman J....Virmani R. (2012)
    538. Expression of leptin and its long-form receptor in the marginal cutaneous tissues of diabetic foot ulcers. (PubMed id 22987225)1 Cao Y....Xue Y.M. (2012)
    539. Leptin and interferon-gamma as possible predictors of cesarean section among women with hypertensive disorders of pregnancy. (PubMed id 22847200)1 Rytlewski K....Reron A. (2012)
    540. Relationship of insulin, glucose, leptin, IL-6 and TNF -a in human breast milk with infant growth and body composition. (PubMed id 22577092)1 Fields D.A. and Demerath E.W. (2012)
    541. High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous fam ilies. (PubMed id 22463805)1 Saeed S....Froguel P. (2012)
    542. Differential signalling through ALK-1 and ALK-5 regula tes leptin expression in mesenchymal stem cells. (PubMed id 22087763)1 Zeddou M....Malaise M.G. (2012)
    543. Association of genome variations in the renin-angioten sin system with physical performance. (PubMed id 23176367)1 Sgourou A....Papachatzopoulou A. (2012)
    544. The unique cysteine knot regulates the pleotropic horm one leptin. (PubMed id 23029163)1 Haglund E....Onuchic J.N. (2012)
    545. Association between metabolic syndrome and serum lepti n levels in postmenopausal women. (PubMed id 22185543)1 Lee S.W....Kim J.H. (2012)
    546. Study of the leptin levels and its gene polymorphisms in patients with idiopathic short stature and growth hormone deficiency. (PubMed id 22350661)1 Su P.H....Chen J.Y. (2012)
    547. Corticotropin-releasing hormone stimulates expression of leptin, 11beta-HSD2 and syncytin-1 in primary human trophoblasts. (PubMed id 22971074)1 Fahlbusch F.B....Dotsch J. (2012)
    548. Association of V89L SRD5A2 polymorphism with craving a nd serum leptin levels in male alcohol addicts. (PubMed id 22707254)1 Lenz B....Kornhuber J. (2012)
    549. The association of leptin and C-reactive protein with the cardiovascular risk factors and metabolic syndrome score in Taiwanese adults . (PubMed id 22533665)1 Chiu F.H....Wang S.H. (2012)
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    551. The plasma leptin/adiponectin ratio predicts first car diovascular event in men: a prospective nested case-control study. (PubMed id 22819464)1 Kappelle P.J....Wolffenbuttel B.H. (2012)
    552. FOSL2 promotes leptin gene expression in human and mou se adipocytes. (PubMed id 22326952)1 Wrann C.D....Rosen E.D. (2012)
    553. Regulation of leptin expression by 17beta-estradiol in human placental cells involves membrane associated estrogen receptor alpha. (PubMed id 22310000)1 Gambino Y.P....Varone C.L. (2012)
    554. Imatinib mesylate therapy induces reduction in neutro phil gelatinase-associated lipocalin serum levels and increase in leptin concen trations in chronic myeloid leukemia patients in molecular remission. (PubMed id 21986252)1 Alonci A....Musolino C. (2012)
    555. Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexi can Americans: a cross-sectional study. (PubMed id 22035595)1 Mirza S....Fisher-Hoch S.P. (2012)
    556. Impact of age on leptin and adiponectin independent of adiposity. (PubMed id 22370102)1 Schautz B....Bosy-Westphal A. (2012)
    557. Prospective, randomized, single-blind comparison of ef fects of 6 months' treatment with atorvastatin versus pravastatin on leptin and angiogenic factors in patients with coronary artery disease. (PubMed id 21643812)1 Takahashi Y....Nakamura M. (2012)
    558. Serum adipokines in osteoarthritis; comparison with co ntrols and relationship with local parameters of synovial inflammation and carti lage damage. (PubMed id 22595228)1 de Boer T.N....Mastbergen S.C. (2012)
    559. Association of TNF-a promoter gene G-308A polymorphism with metabolic syndrome, insulin resistance, serum TNF-a and leptin levels in I ndian adult women. (PubMed id 21616679)1 Gupta V....Agarwal G.G. (2012)
    560. Cord blood leptin levels of healthy neonates are assoc iated with IFN-g production by cord blood T-cells. (PubMed id 22815836)1 Mouzaki A....Farri-Kostopoulou E. (2012)
    561. Functional magnetic resonance imaging analysis of food -related brain activity in patients with lipodystrophy undergoing leptin replace ment therapy. (PubMed id 22872692)1 Aotani D....Nakao K. (2012)
    562. Novel multiplex method to assess insulin, leptin and a diponectin regulation of inflammatory cytokines associated with colon cancer. (PubMed id 22193626)1 Farquharson A.J....Drew J.E. (2012)
    563. Development and characterization of high affinity lep tins and leptin antagonists. (PubMed id 21119198)1 Shpilman M....Gertler A. (2011)
    564. Leptin and the central nervous system control of gluc ose metabolism. (PubMed id 21527729)1 Morton G.J. and Schwartz M.W. (2011)
    565. Is sprint exercise a leptin signaling mimetic in huma n skeletal muscle? (PubMed id 21659488)1 Guerra B....Calbet J.A. (2011)
    566. Serum leptin and ghrelin in chronic hepatitis C patien ts with steatosis. (PubMed id 22171144)1 Pavlidis C....Zouboulis-Vafiadis I. (2011)
    567. Serum retinol-binding protein 4, leptin, and plasma a symmetric dimethylarginine levels in obese and nonobese young women with polycy stic ovary syndrome. (PubMed id 21600576)1 Yildizhan R....Bugdayci G. (2011)
    568. Association of plasma leptin levels and insulin resis tance in diabetic women: a cross-sectional analysis in an Iranian population wi th different results in men and women. (PubMed id 20553219)1 Nakhjavani M....Abbasi M. (2011)
    569. Leptin-mediated cytoskeletal remodeling in chondrocyt es occurs via the RhoA/ROCK pathway. (PubMed id 20886658)1 Liang J....Qiu G. (2011)
    570. Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis. (PubMed id 21346363)1 Kato H....Chihara J. (2011)
    571. Asthma in obese women: outcomes and factors involved. (PubMed id 21721375)1 Kilic H....Turktas H. (2011)
    572. [Relationship between insulin, leptin, and melatonin c ontents in patients with metabolic syndrome]. (PubMed id 22420194)1 (2011)
    573. Association of serum leptin levels with progression of diabetic kidney disease in patients with type 2 diabetes. (PubMed id 21994433)1 Hanai K....Uchigata Y. (2011)
    574. Polymorphisms in three obesity-related genes (LEP, LE PR, and PON1) and breast cancer risk: a meta-analysis. (PubMed id 21887553)1 Liu C. and Liu L. (2011)
    575. Plasma leptin levels and digital pulse volume in obes e patients without metabolic syndrome--a pilot study. (PubMed id 21195702)1 Lin Y.H....Chen M.F. (2011)
    576. Leptin and insulin growth factor 1: diagnostic marker s of the refeeding syndrome and mortality. (PubMed id 21554807)1 Elnenaei M.O....le Roux C.W. (2011)
    577. Association between the leptin gene 2548G/A polymorph ism, the plasma leptin and the metabolic syndrome with psoriasis. (PubMed id 21569107)1 Abdel Hay R.M. and Rashed L.A. (2011)
    578. Adiponectin level as a consequence of genetic variati on, but not leptin level or leptin: adiponectin ratio, is a risk factor for car otid intima-media thickness. (PubMed id 21474811)1 Bevan S....Markus H.S. (2011)
    579. Effects of diabetes family history and exercise train ing on the expression of adiponectin and leptin and their receptors. (PubMed id 20153489)1 Moran C.N....Gill J.M. (2011)
    580. Adipose tissue gene expression of adiponectin, tumor necrosis factor-I+ and leptin in metabolic syndrome patients with coronary arter y disease. (PubMed id 21498926)1 Gormez S....Buyukdevrim A.S. (2011)
    581. In vivo and in vitro evidence that PPARg ligands are a ntagonists of leptin signaling in breast cancer. (PubMed id 21704006)1 Catalano S....Ando S. (2011)
    582. The effect of ponderal index at birth on the relations hips between common LEP and LEPR polymorphisms and adiposity in adolescents. (PubMed id 21512510)1 Labayen I....Gottrand F. (2011)
    583. Potential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin--in chronic hepatitis. (PubMed id 21738955)1 Kukla M....Zwirska-Korczala K. (2011)
    584. Circulating leptin concentrations do not distinguish menstrual status in exercising women. (PubMed id 21227945)1 Corr M....Williams N.I. (2011)
    585. [The role of leptin, adiponectin and insulin-resistan ce markers in development of early stages of chronic kidney disease and atheros clerosis of carotid arteries in obese patients]. (PubMed id 21786576)1 Saginova E.A....Mukhin N.A. (2011)
    586. Leptin, obestatin and apelin levels in patients with obstructive sleep apnoea syndrome. (PubMed id 21358603)1 Zirlik S....Harsch I.A. (2011)
    587. Screening for anorexia nervosa via measurement of seru m leptin levels. (PubMed id 21258826)1 Focker M....Hebebrand J. (2011)
    588. Ghrelin, leptin, adiponectin, and insulin levels and concurrent and future weight change in overweight, postmenopausal women. (PubMed id 21449093)1 Soni A.C....Kuller L.H. (2011)
    589. Plasma leptin levels and risk of breast cancer in pre menopausal women. (PubMed id 21680707)1 Harris H.R....Michels K.B. (2011)
    590. Hypothalamic sites of leptin action linking metabolis m and reproduction. (PubMed id 21099209)1 Donato J....Elias C.F. (2011)
    591. Effects of spa therapy on serum leptin and adiponectin levels in patients with knee osteoarthritis. (PubMed id 20237929)1 Fioravanti A....Blardi P. (2011)
    592. Expression and clinical significance of leptin, the f unctional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis. (PubMed id 21927908)1 Xu Y.J....Yin Y.M. (2011)
    593. Genetic predictors of antipsychotic-induced weight gai n: a case-matched multi-gene study. (PubMed id 21937795)1 Wu R....Chang M. (2011)
    594. Leptin increases motility and integrin up-regulation in human prostate cancer cells. (PubMed id 20945385)1 Huang C.Y....Tang C.H. (2011)
    595. Adipokines and the risk of fracture in older adults. (PubMed id 21312272)1 Barbour K.E....Cauley J.A. (2011)
    596. Third trimester plasma adiponectin and leptin in gesta tional diabetes and normal pregnancies. (PubMed id 21632143)1 Horosz E....Wielgos M. (2011)
    597. Leptin and vascular endothelial growth factor regulat e angiogenesis in tooth germs. (PubMed id 21340571)1 Ide S....Satomura K. (2011)
    598. Hyperleptinaemia positively correlated with metabolic syndrome in hemodialysis patients. (PubMed id 22075293)1 Tsai J.P....Hsu B.G. (2011)
    599. Expression of leptin and leptin receptor isoforms in the rat and human carotid body. (PubMed id 21334312)1 Porzionato A....De Caro R. (2011)
    600. [Expression of leptin and leptin receptor in hepatocel lular carcinoma and the clinicopathological significance]. (PubMed id 21602135)1 Chen L....Dai G.H. (2011)
    601. [Effect of inhibition of cytosolic phospholipase Aa88 o n Leptin release from human umbilical vein endothelial cells induced by lipopol ysaccharide]. (PubMed id 21315000)1 Qi F. and Yan G.T. (2011)
    602. Soluble leptin receptor and leptin are associated wit h baseline adiposity and metabolic risk factors, and predict adiposity, metabol ic syndrome, and glucose levels at 2-year follow-up: the Cyprus Metabolism Pros pective Cohort Study. (PubMed id 21056886)1 Hamnvik O.P....Mantzoros C.S. (2011)
    603. Serum leptin is associated with cardiometabolic risk and predicts metabolic syndrome in Taiwanese adults. (PubMed id 21526991)1 Li W.C....Wu K.H. (2011)
    604. The interplay of YKL-40 and leptin in type 2 diabetic obese patients. (PubMed id 21715039)1 El-Mesallamy H.O....El Demerdash E. (2011)
    605. Leptin expression and leptin receptor gene polymorphi sms in growth hormone deficiency patients. (PubMed id 21207066)1 Su P.H....Yang S.F. (2011)
    606. Association of cocaine- and amphetamine-related transc ript, leptin and leptin receptor gene polymorphisms with anthropometric obesity phenotype indicators in South African learners. (PubMed id 21921635)1 Yako Y.Y....Matsha T.E. (2011)
    607. Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts. (PubMed id 21562093)1 Ge Y.C....Sun K. (2011)
    608. Leptin is better than any other biological parameter for monitoring the efficacy of renutrition in hospitalized malnourished elderly patients. (PubMed id 21521316)1 Nivet-Antoine V....Bouillanne O. (2011)
    609. Effects of body fat on the associations of high-molecu lar-weight adiponectin, leptin and soluble leptin receptor with metabolic syndro me in Chinese. (PubMed id 21347230)1 Yu D....Lin X. (2011)
    610. Association of adiponectin and leptin with serum lipi ds and erythrocyte omega-3 and omega-6 fatty acids in dialysis patients. (PubMed id 21329629)1 An W.S....Vaziri N.D. (2011)
    611. Plasma levels of leptin and soluble leptin receptor a nd polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia. (PubMed id 21631924)1 Skoczen S....Strojny W. (2011)
    612. Adiponectin, AFABP, and leptin in human breast milk d uring 12 months of lactation. (PubMed id 21407103)1 Bronsky J....Nevoral J. (2011)
    613. [The role of promoter CpG islands methylation of lept in gene in osteoarthritis]. (PubMed id 21418891)1 Niu S.P....Yang T. (2011)
    614. Patients with Bardet-Biedl syndrome have hyperleptine mia suggestive of leptin resistance. (PubMed id 21209035)1 Feuillan P.P....Biesecker L.G. (2011)
    615. Lack of association between LEP rs2167270 (19 G>A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis. (PubMed id 21385539)1 GarcA-a-BermA_dez M....GonzA!lez-Gay M.A. (2011)
    616. Butyrate regulates leptin expression through different signaling pathways in adipocytes. (PubMed id 22122897)1 Soliman M.M....Abdel-Aal A.A. (2011)
    617. Relationship between osteoporosis and adipose tissue leptin and osteoprotegerin in patients with chronic obstructive pulmonary disea se. (PubMed id 21376149)1 Pobeha P....Tkacova R. (2011)
    618. Serum leptin levels in relation to circulating cytoki nes, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia. (PubMed id 21906313)1 Molvarec A....RigA^ J. (2011)
    619. Leptin enhances survival and induces migration, degra nulation, and cytokine synthesis of human basophils. (PubMed id 21421855)1 Suzukawa M....Ohta K. (2011)
    620. Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: the Heart and So ul Study. (PubMed id 21176905)1 Ku I.A....Whooley M.A. (2011)
    621. Influence of the metabolic syndrome on leptin and lep tin receptor in breast cancer. (PubMed id 21574190)1 Carroll P.A....Connolly E.M. (2011)
    622. Central leptin activates mitochondrial function and i ncreases heat production in skeletal muscle. (PubMed id 21558317)1 Henry B.A....Clarke I.J. (2011)
    623. Role of leptin and its receptors in the pathogenesis o f thyroid cancer. (PubMed id 22076163)1 Uddin S....Al-Kuraya K.S. (2011)
    624. Effects of weight loss and leptin on skeletal muscle in human subjects. (PubMed id 21917907)1 Baldwin K.M....Rosenbaum M. (2011)
    625. [Expression of HER-2 and leptin in gastric cancer and their clinical significance]. (PubMed id 22335909)1 Geng Y.T....Yin Y.M. (2011)
    626. The change of plasma ghrelin and leptin levels by the development of type 2 diabetes mellitus in patients with alcohol dependence. (PubMed id 21294754)1 Ju A....Kim D.J. (2011)
    627. Leptin reverts pro-apoptotic and antiproliferative ef fects of I+-linolenic acids in BCR-ABL positive leukemic cells: involvement of P I3K pathway. (PubMed id 21991326)1 Beaulieu A....Defresne M.P. (2011)
    628. Human leptin tissue distribution, but not weight loss- dependent change in expression, is associated with methylation of its promoter. (PubMed id 21931275)1 Marchi M....Maffei M. (2011)
    629. Estrogen receptor alpha pathway is involved in leptin -induced ovarian cancer cell growth. (PubMed id 21173433)1 Choi J.H....Leung P.C. (2011)
    630. Body mass index, leptin, and ambulatory blood pressur e variability in healthy adults. (PubMed id 21146171)1 Abramson J.L....Murrah N.V. (2011)
    631. Changes in serum leptin and adiponectin concentrations and insulin resistance after curative parathyroidectomy in moderate to severe p rimary hyperparathyroidism. (PubMed id 22159932)1 Bhadada S.K....Rao D.S. (2011)
    632. [Leptin and activity of tumor necrosis factor alpha r elations with parameters of the trophologic status and digestion in patients wi th chronic obstructive pulmonary disease]. (PubMed id 21675251)1 (2011)
    633. Association study of BMP4, IL6, Leptin, MMP3, and MTN R1B gene promoter polymorphisms and adolescent idiopathic scoliosis. (PubMed id 21228692)1 MA^rocz M....IllAcs T. (2011)
    634. Adiponectin/leptin ratio and metabolic syndrome in a M exican American population. (PubMed id 21968271)1 Mirza S....Fisher-Hoch S.P. (2011)
    635. A polymorphism in the leptin gene promoter is associa ted with anemia in patients with HIV disease. (PubMed id 21926355)1 Vanasse G.J....Berliner N. (2011)
    636. Common adipokine features of neonates and centenarians . (PubMed id 22308847)1 Meazza C....Bozzola M. (2011)
    637. Sleep duration and biomarkers of metabolic function a mong police officers. (PubMed id 21785371)1 Charles L.E....Burchfiel C.M. (2011)
    638. The potential adverse role of leptin resistance in no nalcoholic fatty liver disease: a hypothesis based on critical review of the li terature. (PubMed id 20717042)1 Polyzos S.A....Deretzi G. (2011)
    639. Leptin, adiponectin and ghrelin, new potential mediato rs of ischemic stroke. (PubMed id 22167137)1 Kantorova E....Galajda P. (2011)
    640. Protein-energy wasting modifies the association of gh relin with inflammation, leptin, and mortality in hemodialysis patients. (PubMed id 21178976)1 Carrero J.J....Stenvinkel P. (2011)
    641. Adipocytokines and CD34 progenitor cells in Alzheimer 's disease. (PubMed id 21633502)1 Bigalke B....Laske C. (2011)
    642. Association between the chondrocyte phenotype and the expression of adipokines and their receptors: evidence for a role of leptin bu t not adiponectin in the expression of cartilage-specific markers. (PubMed id 21935928)1 Francin P.J....Presle N. (2011)
    643. Sexual dimorphism in the early life programming of se rum leptin levels in European adolescents: the HELENA study. (PubMed id 21697251)1 Labayen I....Gottrand F. (2011)
    644. Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study. (PubMed id 21632080)1 Dalamaga M....Mantzoros C.S. (2011)
    645. The levels of adiponectin and leptin and their relati on to other markers of cardiovascular risk in patients with psoriasis. (PubMed id 21349112)1 Kaur S....Zilmer M. (2011)
    646. Leptin deficiency and leptin gene mutations in obese c hildren from Pakistan. (PubMed id 21854111)1 Fatima W....Mahmood S. (2011)
    647. The peritoneal leptin, MCP-1 and TNF-I+ in the pathoge nesis of endometriosis-associated infertility. (PubMed id 20825374)1 Tao Y....Luo W. (2011)
    648. Skeletal muscle insulin resistance in morbid obesity: the role of interleukin-6 and leptin. (PubMed id 21811961)1 Mitrou P....Dimitriadis G. (2011)
    649. Insulin sensitivity in late gestation and early postp artum period: the role of circulating maternal adipokines. (PubMed id 21714696)1 Mazaki-Tovi S....Sivan E. (2011)
    650. Leptin and TNF-alpha promoter methylation levels meas ured by MSP could predict the response to a low-calorie diet. (PubMed id 21465273)1 Cordero P....Martinez J.A. (2011)
    651. Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients. (PubMed id 22020349)1 Kuo P.H....Huang M.C. (2011)
    652. Circulating leptin and inflammatory response in esoph ageal cancer, esophageal cancer-related cachexia-anorexia syndrome (CAS) and no n-malignant CAS of the alimentary tract. (PubMed id 20541434)1 Diakowska D....Grabowski K. (2010)
    653. Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effec ts of preoperative chemotherapy. (PubMed id 20569445)1 Koda M....Sulkowski S. (2010)
    654. The association between leptin, interleukin-6, and hi p radiographic osteoarthritis in older people: a cross-sectional study. (PubMed id 20482813)1 Stannus O.P....Ding C. (2010)
    655. Identification of the nasal mucosa as a new target fo r leptin action. (PubMed id 20546344)1 Taildeman J....PAcrez-Novo C.A. (2010)
    656. Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. (PubMed id 20733583)1 Sarzynski M.A....Carlsson L.M. (2010)
    657. New frontiers in gut nutrient sensor research: nutrie nt sensors in the gastrointestinal tract: modulation of sweet taste sensitivity by leptin. (PubMed id 20093782)1 Horio N....Ninomiya Y. (2010)
    658. Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy. (PubMed id 20724651)1 Bouchard L....Brisson D. (2010)
    659. The neuroendocrine basis of lactation-induced suppres sion of GnRH: role of kisspeptin and leptin. (PubMed id 20727862)1 Smith M.S....Grove K.L. (2010)
    660. Clustering of leptin and physical activity with compo nents of metabolic syndrome in Iranian population: an exploratory factor analys is. (PubMed id 21046482)1 Esteghamati A....Gouya M.M. (2010)
    661. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    662. Psychobiology of purging disorder: reduction in circu lating leptin levels in purging disorder in comparison with controls. (PubMed id 19722179)1 Jimerson D.C....Keel P.K. (2010)
    663. Selected adipokines - plasma concentrations and adipo se tissue expressions during 24-hour lipid infusion in healthy men. (PubMed id 19249901)1 KopeckA1 J....PelikA!novA! T. (2010)
    664. Association of ghrelin and leptin with reproductive h ormones in constitutional delay of growth and puberty. (PubMed id 21176234)1 El-Eshmawy M.M....El Hawary A.K. (2010)
    665. The effect of obesity on testicular function by insul in-like factor 3, inhibin B, and leptin concentrations in obese adolescents acc ording to pubertal stages. (PubMed id 20713036)1 Taneli F....Taneli C. (2010)
    666. Increased tissue leptin hormone level and mast cell c ount in skin tags: a possible role of adipoimmune in the growth of benign skin growths. (PubMed id 20826994)1 El Safoury O....Rashed L. (2010)
    667. Adipokines in patients with cancer anorexia and cache xia. (PubMed id 20215915)1 Smiechowska J....Garcia J.M. (2010)
    668. Adiponectin-leptin ratio: a useful estimate of insuli n resistance in patients with Type 2 diabetes. (PubMed id 20142631)1 Zaletel J....Prezelj J. (2010)
    669. Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on w eight gain associated with antipsychotic treatment. (PubMed id 21105276)4 Perez-Iglesias R....Crespo-Facorro B. (2010)
    670. Adipocytokines in subjects with and without ischemic cerebrovascular disease. (PubMed id 21114131)1 Jaleel A....Jaleel F. (2010)
    671. Leptin, soluble leptin receptors, free leptin index, and their relationship with insulin resistance and BMI: high normal BMI is the threshold for serum leptin increase in humans. (PubMed id 20455195)1 Owecki M....SowiA8ski J. (2010)
    672. The modulating effect of the androgen receptor on cra ving in alcohol withdrawal of men is partially mediated by leptin. (PubMed id 19884906)1 Lenz B....Hillemacher T. (2010)
    673. Regulation of placental leptin expression by cyclic a denosine 5'-monophosphate involves cross talk between protein kinase A and mito gen-activated protein kinase signaling pathways. (PubMed id 20484458)1 MaymA^ J.L....Varone C.L. (2010)
    674. Correlation between leptin level and hypertension in normal and obese pre- and postmenopausal women. (PubMed id 20841449)1 Khokhar K.K....Kaur G. (2010)
    675. Serum leptin and adiponectin levels correlate with se verity of allergic rhinitis. (PubMed id 19725899)1 Hsueh K.C....Lin C.Y. (2010)
    676. Relationships between contraction properties of knee extensor muscles and fasting IGF-1 and adipocytokines in physically active post menopausal women. (PubMed id 20633033)1 JA1rimAoe T....JA1rimAoe J. (2010)
    677. Leptin on peritoneal macrophages of patients with end ometriosis. (PubMed id 20047585)1 Wu M.H....Tsai S.J. (2010)
    678. 17Beta-estradiol enhances leptin expression in human placental cells through genomic and nongenomic actions. (PubMed id 20237333)1 Gambino Y.P....Varone C.L. (2010)
    679. Serum osteocalcin is associated with measures of insu lin resistance, adipokine levels, and the presence of metabolic syndrome. (PubMed id 20395593)1 Saleem U....Kullo I.J. (2010)
    680. The polymorphism -2548a88G/A in leptin and severity of Chronic obstructive pulmonary disease. (PubMed id 20854423)1 Ye X.W....Wen F.Q. (2010)
    681. Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. (PubMed id 20220015)1 Tolson K.P....Kublaoui B.M. (2010)
    682. Combined HTR2C-LEP genotype as a determinant of obesit y in patients using antipsychotic medication. (PubMed id 21105285)4 Gregoor J.G....van der Weide J. (2010)
    683. Serum leptin concentrations during the menstrual cycl e in Iranian healthy women. (PubMed id 21287461)1 Einollahi N....Nabatchian F. (2010)
    684. Leptin potentiates antiproliferative action of cAMP e levation via protein kinase A down-regulation in breast cancer cells. (PubMed id 20589829)1 Naviglio S....Spina A. (2010)
    685. Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training. (PubMed id 20517895)1 Huuskonen A....Atalay M. (2010)
    686. Leptin and soluble leptin receptor levels in plasma a nd risk of type 2 diabetes in U.S. women: a prospective study. (PubMed id 19959759)1 Sun Q....Hu F.B. (2010)
    687. Leptin regulates AMPA receptor trafficking via PTEN i nhibition. (PubMed id 20237279)1 Moult P.R....Harvey J. (2010)
    688. Association of LEP and ADIPOQ common variants with co lorectal cancer in Mexican patients. (PubMed id 21263187)1 Partida-PAcrez M....GutiAcrrez-Angulo M. (2010)
    689. Molecular mechanisms of cellular proliferation in acu te myelogenous leukemia by leptin. (PubMed id 20372853)1 Kim J.Y....Lee Y.Y. (2010)
    690. Fasting serum leptin level correlates with mid-arm fa t area in peritoneal dialysis patients. (PubMed id 21118367)1 Fang T.C....Hsu B.G. (2010)
    691. Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. (PubMed id 20413520)1 Mente A.... . (2010)
    692. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. (PubMed id 21123564)1 Koch C....Tups A. (2010)
    693. Serum leptin: a marker of prostate cancer irrespectiv e of obesity. (PubMed id 21045260)1 Singh S.K....Jha V. (2010)
    694. Polymorphisms of the LEP- and LEPR genes, metabolic p rofile after prolonged clozapine administration and response to the antidiabeti c metformin. (PubMed id 20591628)1 FernA!ndez E....Baptista T. (2010)
    695. Insulin resistance, serum leptin, and adiponectin lev els and outcomes of viral hepatitis C cirrhosis. (PubMed id 20728234)1 Nkontchou G....Beaugrand M. (2010)
    696. Sex steroids, growth hormone, leptin and the pubertal growth spurt. (PubMed id 19955758)1 Rogol A.D. (2010)
    697. Associations of polymorphisms in adiponectin and lept in genes with men's longevity. (PubMed id 20201642)1 Khabour O.F....Alzoubi K.H. (2010)
    698. Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway. (PubMed id 20497020)1 Woo H.J....Kim Y.D. (2010)
    699. [The relationship of leptin and adiponectin with insu lin resistance in nonalcoholic fatty liver disease]. (PubMed id 20587319)1 Li Y.L....Wang B.Y. (2010)
    700. Leptin and ghrelin in Korean systemic lupus erythemat osus. (PubMed id 19965946)1 Kim H.A....Suh C.H. (2010)
    701. Associations between serum leptin level and bone turn over in kidney transplant recipients. (PubMed id 20688883)1 Kovesdy C.P....Mucsi I. (2010)
    702. Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity. (PubMed id 19910644)1 Heida N.M....SchAofer K. (2010)
    703. Leptin upregulates telomerase activity and transcript ion of human telomerase reverse transcriptase in MCF-7 breast cancer cells. (PubMed id 20171193)1 Ren H....Hao J. (2010)
    704. Leptin exacerbates sepsis-mediated morbidity and mort ality. (PubMed id 20519646)1 Shapiro N.I....Yano K. (2010)
    705. MAPK and PI3K activities are required for leptin stim ulation of protein synthesis in human trophoblastic cells. (PubMed id 20465992)1 PAcrez-PAcrez A....SA!nchez-Margalet V. (2010)
    706. Association between LEP and LEPR gene polymorphisms a nd dyslipidemia in patients using atypical antipsychotic medication. (PubMed id 20562674)1 Gregoor J.G....Heerdink E.R. (2010)
    707. Leptin is associated with the size of the apolipoprot ein(a) particle in African tribal populations living on fish or vegetarian diet . (PubMed id 20197188)1 Winnicki M....Pauletto P. (2010)
    708. Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma. (PubMed id 20008098)1 Uddin S....Al-Kuraya K.S. (2010)
    709. Serum levels of adipokines resistin and leptin in pat ients with colon cancer. (PubMed id 21254741)1 SA8lA8geanu A....Neagu S. (2010)
    710. Promotion of melanoma growth by the metabolic hormone leptin. (PubMed id 20204272)1 Ellerhorst J.A....Grimm E.A. (2010)
    711. Phenotypic and genetic variation in leptin as determi nants of weight regain. (PubMed id 21042325)1 Erez G....Shai I. (2010)
    712. Relationship between leptin, adiponectin, bone minera l density, and measures of adiposity among pre-menopausal Hispanic and Caucasia n women. (PubMed id 20712424)1 King G.A....Thompson D.L. (2010)
    713. Polymorphisms in 5'-flanking regions of genes encodin g adiponectin, leptin, and resistin are not associated with obesity of Polish c hildren and adolescents. (PubMed id 20842437)1 Cieslak J....Switonski M. (2010)
    714. NF-kappaB activation in hypothalamic pro-opiomelanoco rtin neurons is essential in illness- and leptin-induced anorexia. (PubMed id 20097762)1 Jang P.G....Kim M.S. (2010)
    715. A new missense mutation in the leptin gene causes mil d obesity and hypogonadism without affecting T cell responsiveness. (PubMed id 20382689)1 Fischer-Posovszky P....Wabitsch M. (2010)
    716. Interstitial concentrations of adipokines in subcutan eous abdominal and femoral adipose tissue. (PubMed id 19376162)1 Nielsen N.B....Stallknecht B. (2009)
    717. Leptin concentrations are a predictor of overweight r eduction in a lifestyle intervention. (PubMed id 19922035)1 Reinehr T....Andler W. (2009)
    718. [Human genetic mutations and polymorphisms of adipocytokines relating to obesity] (PubMed id 19202898)1 Hiuge A. and Kihara S. (2009)
    719. The ambiguous role of the Na+-H+ exchanger isoform 1 (NHE1) in leptin-induced oxidative stress in human monocytes. (PubMed id 19301149)1 Konstantinidis D....Kaloyianni M. (2009)
    720. Adipokines in a group of Mexican patients with nonalc oholic steatohepatitis. (PubMed id 19502655)1 MuA+oz L.E....Segura J.J. (2009)
    721. Effects of exercise on energy-regulating hormones and appetite in men and women. (PubMed id 19073905)1 Hagobian T.A....Braun B. (2009)
    722. Effects of adiponectin and leptin co-treatment on hum an breast cancer cell growth. (PubMed id 19424644)1 Nkhata K.J....Cleary M.P. (2009)
    723. Relation of serum leptin to blood pressure of Japanes e in Japan and Japanese-Americans in Hawaii. (PubMed id 19841291)1 Nakamura Y....Stamler J. (2009)
    724. DNA methylation differences after exposure to prenata l famine are common and timing- and sex-specific. (PubMed id 19656776)1 Tobi E.W....Heijmans B.T. (2009)
    725. Postprandial responses in hunger and satiety are asso ciated with the rs9939609 single nucleotide polymorphism in FTO. (PubMed id 19793853)4 den Hoed M....Westerterp K.R. (2009)
    726. The relationship between leptin, gonadotropic hormone s, and body composition during puberty in a Dutch children cohort. (PubMed id 19332528)1 Rutters F....Westerterp-Plantenga M.S. (2009)
    727. Longitudinal analysis of leptin variation during weig ht regain after weight loss in obese children. (PubMed id 20054230)1 Holm J.C....Heitmann B.L. (2009)
    728. Serum and synovial fluid leptin levels and markers of inflammation in rheumatoid arthritis. (PubMed id 19009296)1 Seven A....Hamuryudan V. (2009)
    729. Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin. (PubMed id 19589139)1 Langouche L....Van den Berghe G. (2009)
    730. PACAP neurons in the hypothalamic ventromedial nucleu s are targets of central leptin signaling. (PubMed id 19940178)1 Hawke Z....Luckman S.M. (2009)
    731. Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation. (PubMed id 18988190)1 Catalano S....AndA^ S. (2009)
    732. Adipocytokines are associated with renal function in patients with normal range glomerular filtration rate and type 2 diabetes. (PubMed id 19223200)1 Barlovic D.P....Prezelj J. (2009)
    733. Elevated serum leptin levels: a risk factor for non-small-cell lung cancer? (PubMed id 19033693)1 Terzidis A....Petridou E.T. (2009)
    734. Gene expression of placental hormones regulating energy balance in small for gestational age neonates. (PubMed id 19004538)1 Struwe E....DAPtsch J. (2009)
    735. Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study. (PubMed id 19141993)1 Hung C.Y....Peng S.J. (2009)
    736. Serum leptin level and cognition in the elderly: Find ings from the Health ABC Study. (PubMed id 18358569)1 Holden K.F....Yaffe K. (2009)
    737. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    738. Signaling components involved in leptin-induced amplification of the atherosclerosis-related properties of human monocytes. (PubMed id 18843191)1 Konstantinidis D....Kaloyianni M. (2009)
    739. Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents. (PubMed id 19466592)1 do Prado W.L....DAcmaso A.R. (2009)
    740. Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells. (PubMed id 19112600)1 McMurtry V....Tari A.M. (2009)
    741. A marker of growth differs between adolescents with h igh vs. low sugar preference. (PubMed id 19150454)1 Coldwell S.E....Reed D.R. (2009)
    742. Serum leptin levels and irritable bowel syndrome: a n ew hypothesis. (PubMed id 19398923)1 Semnani S....Joshaghani H. (2009)
    743. Heart-type fatty acid-binding protein is a useful mar ker for organ dysfunction and leptin alleviates sepsis-induced organ injuries b y restraining its tissue levels. (PubMed id 19576209)1 Yan G.T....Wang L.H. (2009)
    744. Serum adipocytokine levels in prostate cancer patients. (PubMed id 19322011)1 Arisan E.D....Ergenekon E. (2009)
    745. Osteoporosis: a neuroskeletal disease? (PubMed id 18761104)1 Takeda S. (2009)
    746. Does an altered leptin axis play a role in obesity among children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency? (PubMed id 19004982)1 VAPlkl T.M....DAPrr H.G. (2009)
    747. Leptin, insulin, and obesity-related phenotypes: gene tic influences on levels and longitudinal changes. (PubMed id 19214176)1 Friedlander Y....Miserez A.R. (2009)
    748. The Q223R polymorphism in LEPR is associated with obe sity in Pacific Islanders. (PubMed id 19921265)4 Furusawa T....Ohashi J. (2009)
    749. Leptin, ciliary neurotrophic factor, leukemia inhibit ory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function. (PubMed id 19751193)1 Dozio E....Magni P. (2009)
    750. Anthropometric and leptin changes in women following different dietary approaches to weight loss. (PubMed id 18997680)1 Miller L.E....Nickols-Richardson S.M. (2009)
    751. Leptin induces migration and invasion of glioma cells through MMP-13 production. (PubMed id 18814267)1 Yeh W.L....Fu W.M. (2009)
    752. Serum leptin levels during pregnancy in multiple scle rosis. (PubMed id 19667019)1 Neuteboom R.F....Hintzen R.Q. (2009)
    753. Sam68 and ERKs regulate leptin-induced expression of OB-Rb mRNA in C2C12 myotubes. (PubMed id 19524014)1 Maroni P....Bendinelli P. (2009)
    754. Leptin does not mediate short-term fasting-induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states. (PubMed id 18445667)1 Chan J.L....Mantzoros C.S. (2008)
    755. Leptin enhances human beta-defensin-2 production in human keratinocytes. (PubMed id 18556347)1 Kanda N. and Watanabe S. (2008)
    756. Serum leptin and its relationship with metabolic variables in Arabs with type 2 diabetes mellitus. (PubMed id 18779635)1 Al-Shoumer K.A....Vasanthy B.A. (2008)
    757. The influence of ghrelin, adiponectin, and leptin on bone mineral density in healthy postmenopausal women. (PubMed id 18979162)1 Jurimae J....Kums T. (2008)
    758. Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma. (PubMed id 18573568)1 Ribatti D....Vacca A. (2008)
    759. Leptin, blood pressure, and aerobic capacity in women. (PubMed id 18756258)1 Sabatier M.J....Cannon J.G. (2008)
    760. Change in adipocytokines and ghrelin with menopause. (PubMed id 18280066)1 Sowers M.R....Jannausch M.L. (2008)
    761. [A new mutation c.422C>G (p.S141C) in homo- and heterozygous forms of the human leptin gene] (PubMed id 19088762)1 Chekhranova M.K....Pankov I.u.A. (2008)
    762. Low leptin levels in migraine: a case control study. (PubMed id 18547265)1 Guldiken B....Tugrul A. (2008)
    763. Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia. (PubMed id 18515891)1 Yevtushenko O.O....Reynolds G.P. (2008)
    764. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? (PubMed id 17347881)1 Ashwood P....Van de Water J. (2008)
    765. Psoriasis independently associated with hyperleptinemia contributing to metabolic syndrome. (PubMed id 19075139)1 Chen Y.J....Chen C.M. (2008)
    766. Seven placental transcripts characterize HELLP-syndrome. (PubMed id 18374411)1 Buimer M....Ris-Stalpers C. (2008)
    767. Plasma and synovial fluid adipocytokines in patients with rheumatoid arthritis and osteoarthritis. (PubMed id 20306680)1 Ibrahim S.M....Amer N. (2008)
    768. Centrally located body fat is related to appetitive hormones in healthy postmenopausal women. (PubMed id 18390991)1 Ritland L.M....Genschel U. (2008)
    769. Leptin and regulation of linear growth. (PubMed id 18403928)1 Gat-Yablonski G. and Phillip M. (2008)
    770. Hyperleptinemia is associated with hypertension in Japanese males. (PubMed id 18596833)1 Imatoh T....Doi H. (2008)
    771. Sympathetic overactivity and plasma leptin levels in Rett syndrome. (PubMed id 18226448)1 Acampa M....Auteri A. (2008)
    772. AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity. (PubMed id 18255222)1 Janovska A....Wittert G.A. (2008)
    773. Contribution of leptin receptor N-linked glycans to leptin binding. (PubMed id 17983356)1 Kamikubo Y....Ruggeri Z.M. (2008)
    774. Leptin expression in Peripheral Blood Mononuclear Cells (PBMCs) is related with blood pressure variability. (PubMed id 18501706)1 Samara A....Visvikis-Siest S. (2008)
    775. cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin. (PubMed id 18253488)1 Yang D.C....Hung S.C. (2008)
    776. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. (PubMed id 18568078)1 Rosenbaum M....Hirsch J. (2008)
    777. Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes. (PubMed id 18463145)1 Wang B....Trayhurn P. (2008)
    778. Insulin resistance, physical fitness, body composition and leptin concentration in 7-8 year-old children. (PubMed id 17215165)1 Slinger J.D....Kuipers H. (2008)
    779. Screening of hypoxia-inducible genes in sporadic ALS. (PubMed id 18608101)4 Cronin S....Hardiman O. (2008)
    780. Negative effect of leptin on bone mass in type 1 diabetes. (PubMed id 18690407)1 Kassem H.S....Azar S.T. (2008)
    781. Leptin as a neuroprotective agent. (PubMed id 18222172)1 Tang B.L. (2008)
    782. Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels. (PubMed id 18633111)1 Nakamura Y....Ninomiya Y. (2008)
    783. The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis? (PubMed id 18552206)1 Matarese G....De Rosa V. (2008)
    784. Influence of Lys656Asn polymorphism of the leptin receptor gene on insulin resistance in nondiabetic obese patients. (PubMed id 18413223)1 de Luis D.A....Conde R. (2008)
    785. Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha. (PubMed id 17653093)1 Cascio S....Surmacz E. (2008)
    786. Polysomnographic sleep, growth hormone insulin-like growth factor-I axis, leptin, and weight loss. (PubMed id 18464752)1 Rasmussen M.H....Hilsted J. (2008)
    787. Leptin affects proliferation-, apoptosis- and protein kinase A-related peptides in human ovarian granulosa cells. (PubMed id 17465693)1 Sirotkin A.V....Hetenyi L. (2008)
    788. Gender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity. (PubMed id 18941624)1 Guerra B....Calbet J.A. (2008)
    789. Increased serum levels of leptin in retinal vein occlusion. (PubMed id 18679012)1 Ates O....Baykal O. (2008)
    790. Low leptin but high insulin resistance of smokers in Japanese men. (PubMed id 18579252)1 Hotta Y....Tamakoshi K. (2008)
    791. Leptin replacement improves cognitive development. (PubMed id 18769731)1 Paz-Filho G.J....Licinio J. (2008)
    792. Relationships between finger-length ratios, ghrelin, leptin, IGF axis, and sex steroids in young male and female swimmers. (PubMed id 18584199)1 Jurimae T....Purge P. (2008)
    793. Atherogenecity of LDL and unfavorable adipokine profile in metabolically obese, normal-weight woman. (PubMed id 18239579)1 Hyun Y.J....Lee J.H. (2008)
    794. Serum leptin in systemic lupus erythematosus. (PubMed id 18196243)1 Wisl/owska M....Kuklo-Kowalska A. (2008)
    795. Panel of markers can accurately predict endometriosis in a subset of patients. (PubMed id 17706208)1 Seeber B....Barnhart K.T. (2008)
    796. Polymorphism within the intron region of the bovine leptin gene in Iranian Sarabi cattle (Iranian Bos taurus). (PubMed id 18666562)1 Javanmard A....Asadzadeh N. (2008)
    797. Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion. (PubMed id 18658052)1 Schroeter M.R....Schafer K. (2008)
    798. Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. (PubMed id 18978578)1 Zhao C.Q....Dai L.Y. (2008)
    799. Central nervous system regulation of energy metabolism: ghrelin versus leptin. (PubMed id 18448790)1 Nogueiras R....Zigman J.M. (2008)
    800. Concomitant activation of the JAK/STAT3 and ERK1/2 si gnaling is involved in leptin-mediated proliferation of renal cell carcinoma Ca ki-2 cells. (PubMed id 18787400)1 Li L....He D.L. (2008)
    801. Serum adiponectin and leptin concentrations in patients with chronic pancreatitis of alcoholic and nonalcoholic origin. (PubMed id 18376301)1 Adrych K....Swierczynski J. (2008)
    802. Serum leptin level in acute myeloid leukemia patients. (PubMed id 18534061)1 Yilmaz M....Tarakcioglu M. (2008)
    803. Leptin regulates the proliferation and apoptosis of human endometrial epithelial cells. (PubMed id 18949391)1 Tanaka T. and Umesaki N. (2008)
    804. [Role of adipocytokine in bone metabolism] (PubMed id 18445880)1 Ebina K....Shimomura I. (2008)
    805. Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin Study. (PubMed id 18299466)1 Lappalainen T....Gylling H. (2008)
    806. Leptin G-2548A promoter polymorphism is associated wi th increased plasma leptin and BMI in Brazilian women. (PubMed id 18604373)1 Hinuy H.M....Hirata R.D. (2008)
    807. Investigation for the leptin 1 and LEP G2548A gene polymorphism in psoriasis. (PubMed id 18474470)1 Senturk N....Turanli A.Y. (2008)
    808. Balance of adiponectin and leptin modulates breast cancer cell growth. (PubMed id 18957939)1 Grossmann M.E....Cleary M.P. (2008)
    809. Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence. (PubMed id 17535427)1 Noer A....Collas P. (2007)
    810. [Leptin, leptin gene, leptin gene receptor polymorphisms and pregnancy] (PubMed id 18050615)1 Iciek R....Brazert J. (2007)
    811. Plasma ghrelin is altered after maximal exercise in elite male rowers. (PubMed id 17609506)1 Jurimae J....Purge P. (2007)
    812. Serum leptin correlates in infertile oligozoospermic males. (PubMed id 17714215)1 Hanafy S....Khalil K.T. (2007)
    813. Peripheral leptin levels in narcoleptic patients. (PubMed id 17705690)1 Dahmen N....Tonn P. (2007)
    814. Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study. (PubMed id 17967974)1 Golledge J....Norman P.E. (2007)
    815. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    816. Elevated plasma adiponectin and leptin levels in sisters with genetically defective insulin receptors. (PubMed id 17965293)1 Hattori Y....Kasai K. (2007)
    817. Serum acylated ghrelin, adiponectin and leptin levels in normal-weight and obese premenopausal women. (PubMed id 17992641)1 Krzyzanowska-Swiniarska B....Pilarska K. (2007)
    818. Leptin predicts the development of diabetes in Mauritian men, but not women: a population-based study. (PubMed id 17325688)1 Soderberg S....Shaw J.E. (2007)
    819. Innate immunity modulates adipokines in humans. (PubMed id 17374708)1 Anderson P.D....Reilly M.P. (2007)
    820. Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. (PubMed id 16580675)1 Zhang Y.Y....Doria A. (2007)
    821. Leptin serum levels in the first year post-renal transplantation. (PubMed id 17362752)1 Souza G.C....Manfro R.C. (2007)
    822. Body Mass Index, percent body fat, and regional body fat distribution in relation to leptin concentrations in healthy, non-smoking postmenopausal women in a feeding study. (PubMed id 17229323)1 Mahabir S....Taylor P.R. (2007)
    823. Sex differences in the association between leptin and CRP: results from the Dallas Heart Study. (PubMed id 17141244)1 Abdullah Lemos J.A. (2007)
    824. Time course and determinants of leptin decline during weight loss in obese boys and girls. (PubMed id 17763005)1 Holm J.C....Sorensen T.I. (2007)
    825. Leptin regulates striatal regions and human eating behavior. (PubMed id 17690262)1 Farooqi I.S....Fletcher P.C. (2007)
    826. The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle. (PubMed id 17333366)1 Hill M.J....Frattarelli J.L. (2007)
    827. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. (PubMed id 17344214)1 Saxena N.K....Sharma D. (2007)
    828. Relationship between blood adipocytokines and resting energy expenditure in young and elderly women. (PubMed id 18202542)1 Usui C....Higuchi M. (2007)
    829. Serum leptin levels in patients with ocular and nonocular Behcet's disease. (PubMed id 17641728)1 Yalcindag F.N....Caglayan O. (2007)
    830. Influence of BMI and gender on postprandial hormone responses. (PubMed id 18198306)1 Carroll J.F....Caffrey J.L. (2007)
    831. Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations. (PubMed id 17957153)1 James R.J....Cheetham T.D. (2007)
    832. Low CSF leptin levels are associated with worse learning and memory performance in HIV-infected men. (PubMed id 18040853)1 Huang J.S....Ellis R. (2007)
    833. Serum leptin levels correlate with interleukin-6 levels and disease activity in patients with ankylosing spondylitis. (PubMed id 17476615)1 Park M.C....Lee S.K. (2007)
    834. Leptin signalling and leptin-mediated activation of human platelets: importance of JAK2 and the phospholipases Cgamma2 and A2. (PubMed id 18000612)1 Dellas C....Konstantinides S.V. (2007)
    835. Leptin and its correlation with exocrine and endocrine pancreatic function in idiopathic chronic pancreatitis: implications for pathophysiology. (PubMed id 17895848)1 Midha S....Garg P.K. (2007)
    836. Increased insulin sensitivity in patients with anorexia nervosa: the role of adipocytokines. (PubMed id 17184143)1 Dostalova I....Nedvidkova J. (2007)
    837. Roles of leptin in prenatal and perinatal brain development. (PubMed id 17688465)1 Udagawa J....Otani H. (2007)
    838. Oxidative status and serum leptin levels in obese prepubertal children. (PubMed id 16874844)1 Ustundag B....Yilmaz E. (2007)
    839. Leptin in embryos from control and diabetic rats during organogenesis: a modulator of nitric oxide production and lipid homeostasis. (PubMed id 17506117)1 White V....Jawerbaum A. (2007)
    840. Plasma leptin levels and coronary artery calcification in older adults. (PubMed id 17148566)1 Iribarren C....Fortmann S.P. (2007)
    841. Expression of leptin, leptin receptor, and hypoxia-inducible factor 1 alpha in human endometrial cancer. (PubMed id 17404022)1 Koda M....Sulkowski S. (2007)
    842. Leptin induces C-reactive protein expression in vascular endothelial cells. (PubMed id 17615382)1 Singh P....Somers V.K. (2007)
    843. The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer. (PubMed id 18004080)1 Liu C.L....Chen C.P. (2007)
    844. Childhood obesity and its relation to serum adiponectin and leptin: a report from a population-based study. (PubMed id 17118479)1 Nishimura R....Tajima N. (2007)
    845. Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. (PubMed id 17350295)1 Simopoulou T....Tsezou A. (2007)
    846. Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis. (PubMed id 17617917)1 Al-Daghri N.M....Kumar S. (2007)
    847. Leptin directly controls proliferation, apoptosis and secretory activity of cultured chicken ovarian cells. (PubMed id 17604668)1 Sirotkin A.V. and Grossmann R. (2007)
    848. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. (PubMed id 17726024)1 Gong Y....Myers M.G. (2007)
    849. Reduced brain leptin in patients with major depressive disorder and in suicide victims. (PubMed id 16936761)1 Eikelis N....Lambert G. (2006)
    850. Intra-follicular leptin concentration as a predictive factor for in vitro oocyte fertilization in assisted reproductive techniques. (PubMed id 17033261)1 De Placido G....Matarese G. (2006)
    851. Changes in placental adipocytokine gene expression associated with gestational diabetes mellitus. (PubMed id 16343040)1 Meller M....Williams M.A. (2006)
    852. Association of serum leptin with anemia in maintenance hemodialysis patients. (PubMed id 17186687)1 Nasri H. (2006)
    853. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. (PubMed id 16804073)1 Biddinger S.B....Kahn C.R. (2006)
    854. Serum leptin is not a diagnostic marker for familial Mediterranean fever attacks. (PubMed id 16883064)1 Toy B....Tiftikci A. (2006)
    855. Loss of resistin improves glucose homeostasis in leptin deficiency. (PubMed id 17065346)1 Qi Y....Ahima R.S. (2006)
    856. Perceived psychological stress and serum leptin concentrations in Japanese men. (PubMed id 17062814)1 Otsuka R....Toyoshima H. (2006)
    857. A physiological role of breast milk leptin in body weight control in developing infants. (PubMed id 16988079)1 Miralles O....Pico C. (2006)
    858. Insulinemia and leptinemia in geriatric patients: markers of the metabolic syndrome or of undernutrition? (PubMed id 16799400)1 Bonin-Guillaume S....Vischer U.M. (2006)
    859. Genetics of obesity in humans. (PubMed id 17122358)1 Farooqi S. and O'Rahilly S. (2006)
    860. Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women. (PubMed id 16705078)1 Kok P....Pijl H. (2006)
    861. [Relationship between leptin gene of adipose tissues and nonalcoholic fatty liver disease] (PubMed id 17125610)1 Yang H....Sha W.H. (2006)
    862. Leptin and adiponectin levels in acute pancreatitis. (PubMed id 16552343)1 Tukiainen E....Repo H. (2006)
    863. Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers. (PubMed id 16609020)1 Revillion F....Peyrat J.P. (2006)
    864. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. (PubMed id 16582918)1 Chen K....Zhao A.Z. (2006)
    865. Hyperleptinemia is not responsible for decreased paraoxonase activity in hemodialysis patients. (PubMed id 16534235)1 Varga Z....Bajnok L. (2006)
    866. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    867. Prolonged fasting in patients with chronic pain syndromes leads to late mood-enhancement not related to weight loss and fasting-induced leptin depletion. (PubMed id 17263085)1 Michalsen A....Dobos G.J. (2006)
    868. Leptin enhances in vitro secretion of IgG antiplatelet antibodies by splenocytes and peripheral blood mononuclear cells from patients with chronic idiopathic thrombocytopenic purpura. (PubMed id 16774845)1 Ren H....Han Z.C. (2006)
    869. Variation in expression of gastric leptin according to differentiation and growth pattern in gastric adenocarcinoma. (PubMed id 16434209)1 Hong S.J....Kim B.S. (2006)
    870. The Gln223Arg polymorphism of the leptin receptor gene and peripheral blood/bone marrow leptin level in leukemic children. (PubMed id 17072067)1 Wasik M....Demkow U. (2006)
    871. In vivo methylation patterns of the leptin promoter in human and mouse. (PubMed id 17965621)1 Stoger R. (2006)
    872. Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. (PubMed id 15882975)1 Pai R....Tarnawski A. (2005)
    873. Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. (PubMed id 16009333)1 Caldefie-Chezet F....Vasson M.P. (2005)
    874. Leptin and its receptors in human fetal and adult ovaries. (PubMed id 16359991)1 Abir R....Fisch B. (2005)
    875. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. (PubMed id 15905523)1 Mattioli B....Viora M. (2005)
    876. Study of serum factors potentially involved in the pathogenesis of heterotopic bone formation after severe brain injury. (PubMed id 15797495)1 Rigaux P....Hardouin P. (2005)
    877. Serum and urine leptin concentration in children with nephrotic syndrome. (PubMed id 15782310)1 Wasilewska A....Koput A. (2005)
    878. Serum leptin and lactational amenorrhea in well-nourished and undernourished lactating women. (PubMed id 15820811)1 Tennekoon K.H....Karunanayake E.H. (2005)
    879. Salivary leptin induces increased expression of growth factors in oral keratinocytes. (PubMed id 15821102)1 Groschl M....Rauh M. (2005)
    880. [Study of the impact of candidate genes on bone mineral density in postmenopausal women] (PubMed id 16412323)1 Zhao H.Y....Chen J.L. (2005)
    881. Maternal recreational physical activity is associated with plasma leptin concentrations in early pregnancy. (PubMed id 15576385)1 Ning Y....Sorensen T.K. (2005)
    882. Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects. (PubMed id 16273647)1 Mendez-Sanchez N....Uribe M. (2005)
    883. The postoperative stress response and its reflection in cytokine network and leptin plasma levels. (PubMed id 15588161)1 Chachkhiani I....Lindner J. (2005)
    884. Independent association between leptin and blood pressure during third trimester in normal and gestational diabetic pregnancies. (PubMed id 15808376)1 Buhling K.J....Dudenhausen J.W. (2005)
    885. Coelomic fluid leptin concentration in normal first-trimester pregnancies and missed miscarriages. (PubMed id 16113562)1 Makrydimas G....Nicolaides K.H. (2005)
    886. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)1 Martens N....Gertler A. (2005)
    887. Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. (PubMed id 15864530)1 Scarpace P.J....Zhang Y. (2005)
    888. Apoptotic pathways are inhibited by leptin receptor activation in neutrophils. (PubMed id 15944317)1 Bruno A....Simon H.U. (2005)
    889. Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists. (PubMed id 15952938)1 Niv-Spector L....Gertler A. (2005)
    890. Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. (PubMed id 15724240)1 Mabuchi T....Toyoshima H. (2005)
    891. Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents. (PubMed id 15660115)1 Guizar-Mendoza J.M....Sanchez-Corona J. (2005)
    892. Correlation of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function in Chinese patients with chronic hepatitis C virus infection. (PubMed id 15948239)1 Liu Z.W....Wang X.Q. (2005)
    893. Relationship between leptin and bone mineral density in renal transplant recipients. (PubMed id 16213321)1 Agras P.I....Haberal M. (2005)
    894. Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. (PubMed id 15677491)1 Ducroc R....Bado A. (2005)
    895. Effects of different weight loss protocols on serum leptin levels in obese females. (PubMed id 15588160)1 Ozcelik O....Kelestimur H. (2005)
    896. Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. (PubMed id 15736103)1 Inoue M....Suzuki S. (2005)
    897. Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats. (PubMed id 16166222)1 van Dijk G....Scheurink A.J. (2005)
    898. The leptin system during human endometrial receptivity and preimplantation development. (PubMed id 15126576)1 Cervero A....Simon C. (2004)
    899. Serum leptin levels in patients with idiopathic thrombocytopenic purpura. (PubMed id 15059070)1 Zhan M....Han Z.C. (2004)
    900. Effects of leptin and leptin fragments on corticosterone secretion and growth of cultured rat adrenocortical cells. (PubMed id 15492859)1 Malendowicz L.K....Rucinski M. (2004)
    901. Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population. (PubMed id 15254881)1 Ogawa T....Saruta T. (2004)
    902. Serum leptin concentrations in patients with severe ovarian hyperstimulation syndrome during in vitro fertilization-embryo transfer treatment. (PubMed id 15374699)1 Ayustawati ....Suzuki M. (2004)
    903. Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates. (PubMed id 15181040)1 Wong S.L....Mantzoros C.S. (2004)
    904. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. (PubMed id 15478389)1 Gurkan F....Mete N. (2004)
    905. Relationship between plasma leptin and zinc levels and the effect of insulin and oxidative stress on leptin levels in obese diabetic patients. (PubMed id 15607649)1 Konukoglu D....Serin O. (2004)
    906. Leptin levels in the acute stage of ulcerative colitis. (PubMed id 15012781)1 Tuzun A....Dagalp K. (2004)
    907. Leptin regulation of the thyroids: negative regulation on thyroid hormone levels in euthyroid subjects and inhibitory effects on iodide uptake and Na+/I- symporter mRNA expression in rat FRTL-5 cells. (PubMed id 15351798)1 Isozaki O....Takano K. (2004)
    908. Leptin and prolactin modulate the expression of SOCS-1 in association with interleukin-6 and tumor necrosis factor-alpha in mammary cells: a role in differentiated secretory epithelium. (PubMed id 15256287)1 Motta M....Baratta M. (2004)
    909. Leptin and altitude in the cardiovascular diseases. (PubMed id 15483214)1 Cabrera de Leon A....Trujillo I.C. (2004)
    910. Leptin expression in breast nipple aspirate fluid (NAF) and serum is influenced by body mass index (BMI) but not by the presence of breast cancer. (PubMed id 15156414)1 Sauter E.R....Surmacz E. (2004)
    911. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. (PubMed id 15231997)1 Yildiz B.O....Licinio J. (2004)
    912. Comparison of leptin gene expression in different adipose tissues in children and adults. (PubMed id 15080789)1 Schoof E....Dotsch J. (2004)
    913. Rapid inhibition of leptin signaling by glucocorticoids in vitro and in vivo. (PubMed id 14993217)1 Ishida-Takahashi R....Eguchi K. (2004)
    914. The leptin receptor in human osteoblasts and the direct effect of leptin on bone metabolism. (PubMed id 15624271)1 Iwamoto I....Douchi T. (2004)
    915. Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients. (PubMed id 15324935)1 Chatzantoni K....Mouzaki A. (2004)
    916. Serum leptin values in relation to bone density and growth hormone-insulin like growth factors axis in healthy men. (PubMed id 14761840)1 Papadopoulou F....Constantinidis T.C. (2004)
    917. Leptin and nitric oxide production in normotensive and hypertensive men. (PubMed id 15340103)1 Tsuda K. and Nishio I. (2004)
    918. Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice. (PubMed id 15126241)1 Delporte M.L....Brichard S.M. (2004)
    919. Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. (PubMed id 15277432)1 Morales A....Atkinson M. (2004)
    920. Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartments. (PubMed id 14715859)1 Wong M.L....Gold P.W. (2004)
    921. Relationship between serum adiponectin and leptin concentrations and body fat distribution. (PubMed id 14739054)1 Park K.G....Lee I.K. (2004)
    922. Modulation of direct leptin signaling by soluble leptin receptor. (PubMed id 15016839)1 Yang G....Li C. (2004)
    923. Enhanced long-term reduction of plasma leptin concentrations by super-flux polysulfone dialysers. (PubMed id 14993491)1 van Tellingen A....Nube M.J. (2004)
    924. Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor. (PubMed id 15336575)1 Shimamura M....Shimomura I. (2004)
    925. Determinants of plasma leptin concentration in postmenopausal women. (PubMed id 15037014)1 Brooks-Asplund E.M....Cannon J.G. (2004)
    926. Elevation of breast milk leptin levels by laughter. (PubMed id 15114526)1 Kimata H. (2004)
    927. [Bone mass regulation by leptin: a hypothalamic control of bone formation] (PubMed id 15063934)1 Elefteriou F. and Karsenty G. (2004)
    928. Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase. (PubMed id 12902351)1 Onuma M....Iwamoto Y. (2003)
    929. Circadian rhythmicity of salivary leptin in healthy subjects. (PubMed id 12649069)1 Randeva H.S....Hillhouse E.W. (2003)
    930. Inverse correlation between peritoneal fluid leptin concentrations and the extent of endometriosis. (PubMed id 12773447)1 Mahutte N.G....Arici A. (2003)
    931. Serum leptin levels in neonatal bacterial septicemia. (PubMed id 12880122)1 Orbak Z....Ors R. (2003)
    932. Maternal and umbilical cord serum leptin concentrations in small-for-gestational-age and in appropriate-for-gestational-age neonates: a maternal, fetal, or placental contribution? (PubMed id 12890940)1 Grisaru-Granovsky S....Samueloff A. (2003)
    933. The-2548G/A polymorphism in the human leptin gene promoter region is associated with plasma free leptin levels; interaction with adiposity and gender in healthy subjects. (PubMed id 17003027)1 Yiannakouris N....Mantzoros C.S. (2003)
    934. Serum leptin, prolactin and vascular endothelial growth factor (VEGF) levels in patients with breast cancer. (PubMed id 12687277)1 Coskun U....Ozkan S. (2003)
    935. Serum leptin levels, bone mineral density and osteoblast alkaline phosphatase activity in elderly men and women. (PubMed id 12663125)1 Scariano J.K....Baumgartner R.N. (2003)
    936. Potential association between endogenous leptin and sympatho-vagal activities in young obese Japanese women. (PubMed id 12552573)1 Matsumoto T....Moritani T. (2003)
    937. Association between serum leptin levels and 24-hour blood pressure in obese women. (PubMed id 12690084)1 Guagnano M.T....Davi G. (2003)
    938. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
    939. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. (PubMed id 12634434)1 van Rossum C.T....Seidell J.C. (2003)
    940. [Blood leptin level of 154 Chinese children 0 - 14 years of age] (PubMed id 14746672)1 Ding Z.Y....Du L.R. (2003)
    941. Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells. (PubMed id 12665505)1 Kim G.S....Cheng S.L. (2003)
    942. Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines. (PubMed id 12590942)1 Muraoka O....Higuchi H. (2003)
    943. Serum leptin activity in obese and lean patients. (PubMed id 12609752)1 Friedman-Einat M....Strosberg A.D. (2003)
    944. Leptin response to short-term fasting in sympathectomized men: role of the SNS. (PubMed id 12556356)1 Jeon J.Y....Steadward R.D. (2003)
    945. Leptin: a potential marker of placental insufficiency. (PubMed id 12865594)1 Lepercq J....Hauguel-de Mouzon S. (2003)
    946. Leptin and leptin receptor in human seminal plasma and in human spermatozoa. (PubMed id 14636218)1 Jope T....Glander H.J. (2003)
    947. Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. (PubMed id 12788897)1 Gavrila A....Mantzoros C.S. (2003)
    948. The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men. (PubMed id 12637980)1 Zitzmann M....Nieschlag E. (2003)
    949. Relation between leptin and body fat distribution in menopausal status. (PubMed id 15164950)1 Martinez-Carpio P.A....Corominas A. (2003)
    950. Bound leptin and sympathetic outflow in nonobese men. (PubMed id 14557480)1 Tank J....Brabant G. (2003)
    951. Leptin response to glucocorticoid occurs at physiological doses and is abolished by fasting. (PubMed id 12582219)1 Dagogo-Jack S....Tykodi G. (2003)
    952. Leptin, soluble leptin receptor, and transforming growth factor-beta1 levels in minimal change nephrotic syndrome. (PubMed id 12898374)1 Buyan N....Hasanoglu E. (2003)
    953. Relationships between the serum levels of soluble leptin receptor and free and bound leptin in non-pregnant women of reproductive age and women undergoing controlled ovarian hyperstimulation. (PubMed id 12660261)1 Kado N....Honjo H. (2003)
    954. Intact sympathetic nervous system is required for leptin effects on resting metabolic rate in people with spinal cord injury. (PubMed id 12519883)1 Jeon J.Y....Harber V. (2003)
    955. Stearoyl-CoA desaturase-1 and the metabolic syndrome. (PubMed id 14683458)1 Cohen P....Friedman J.M. (2003)
    956. Influence of physical training on plasma leptin in obese youths. (PubMed id 12955866)1 Barbeau P....Owens S. (2003)
    957. C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. (PubMed id 14506615)1 Kazumi T....Yoshino G. (2003)
    958. Leptin and cytokines levels in children with failure to thrive. (PubMed id 14508221)1 Shaoul R....Jaffe M. (2003)
    959. Fat body mass, leptin and femur bone mineral density in hip-fractured women. (PubMed id 15055469)1 Di Monaco M....Cavanna A. (2003)
    960. Plasma leptin, fatty acids, and tumor necrosis factor-receptor and insulin resistance in children. (PubMed id 12690082)1 Chu N.F....Shieh S.M. (2003)
    961. Free-to-total leptin ratio in maternal plasma is constant throughout human pregnancy. (PubMed id 14599116)1 Nuamah M.A....Fujii S. (2003)
    962. Comparative analysis of expression and secretion of placental leptin in mammals. (PubMed id 12702488)1 Zhao J....Widmaier E.P. (2003)
    963. Amniotic fluid and maternal serum leptin levels in pregnant women who subsequently develop preeclampsia. (PubMed id 12694970)1 Chan T.F....Yuan S.S. (2003)
    964. Leptin and bone mineral density: a cross-sectional study in obese and nonobese men. (PubMed id 14671171)1 Morberg C.M....Astrup A. (2003)
    965. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. (PubMed id 12899679)1 Mullington J.M....Mantzoros C.S. (2003)
    966. A model for modulation of leptin activity by association with clusterin. (PubMed id 12824284)1 Bajari T.M....Schneider W.J. (2003)
    967. IP-10, but not RANTES, is upregulated by leptin in monocytic cells. (PubMed id 12668159)1 Meier C.A....Dayer J.M. (2003)
    968. Polymorphisms in exon 3 of the proopiomelanocortin gene in relation to serum leptin, salivary cortisol, and obesity in Swedish men. (PubMed id 11979399)1 Rosmond R....Bjorntorp P. (2002)
    969. Serum leptin levels in patients with premature ejaculation. (PubMed id 12230820)1 Atmaca M....Ayar A. (2002)
    970. Prediction of exercise-mediated changes in metabolic markers by gene polymorphism. (PubMed id 12062855)1 Kahara T....Kobayashi K. (2002)
    971. Serum leptin level and restrained eating: study with the Eating Disorder Examination. (PubMed id 11890967)1 Adami G....Ferrandes G. (2002)
    972. Differences in leptin production by regional fat mass in postmenopausal women. (PubMed id 12402972)1 Douchi T....Nagata Y. (2002)
    973. Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes. (PubMed id 12010881)1 Barrenetxe J....Lostao M.P. (2002)
    974. Genetic diversity and evolution of the human leptin locus tetranucleotide repeat. (PubMed id 12073010)1 Moffett S....Ferrell R.E. (2002)
    975. Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2. (PubMed id 11997181)1 Gualillo O....Casanueva F.F. (2002)
    976. Leptin enhances the effect of transforming growth factor beta in increasing type I collagen formation. (PubMed id 12359239)1 Tang M....Mezey E. (2002)
    977. Serum leptin levels of menopausal women before and after hormone replacement therapy. (PubMed id 12376297)1 Li W.L....Zhang Y.L. (2002)
    978. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    979. Role of leptin in glucose metabolism in type 2 diabetes. (PubMed id 12047393)1 Al-Daghri N....Kumar S. (2002)
    980. [The changes in plasma leptin, insulin and proinsulin levels in obese adolescents] (PubMed id 12133430)1 Zhang J....Dong A. (2002)
    981. Leptin induces endothelin-1 in endothelial cells in vitro. (PubMed id 11934840)1 Quehenberger P....Wagner O. (2002)
    982. Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin. (PubMed id 12105280)1 Laimer M....Patsch J.R. (2002)
    983. Leptin mediates a proliferative response in human MCF7 breast cancer cells. (PubMed id 12054648)1 Dieudonne M.N....Giudicelli Y. (2002)
    984. Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. (PubMed id 12213831)1 Melzner I....Moller P. (2002)
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    987. Leptin concentrations experience a delayed reduction after resistance exercise in men. (PubMed id 11932568)1 Nindl B.C....Hafeman D.L. (2002)
    988. Maternal serum leptin concentration during the second trimester of pregnancy: association with fetal chromosomal abnormalities. (PubMed id 11920898)1 Rizos D....Salamalekis E. (2002)
    989. A quantitative trait locus on chromosome 22 for serum leptin levels adjusted for serum testosterone. (PubMed id 12105281)1 Martin L.J....Comuzzie A.G. (2002)
    990. Leptin and the treatment of obesity: its current status. (PubMed id 12007531)1 Lee D.W....Grasso P. (2002)
    991. Hypoxia-inducible factor 1 transactivates the human l eptin gene promoter. (PubMed id 12215445)1 Grosfeld A....Guerre-Millo M. (2002)
    992. Relationship between changes in serum leptin levels and blood pressure after weight loss. (PubMed id 12484512)1 Itoh K....Nakamura M. (2002)
    993. Secretion of free and protein-bound leptin from subcutaneous adipose tissue of lean and obese women. (PubMed id 12161541)1 Brabant G....Arner P. (2002)
    994. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. (PubMed id 12153737)1 Matsubara M....Katayose S. (2002)
    995. A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response. (PubMed id 14561193)1 Waelput W....Tavernier J. (2002)
    996. Higher serum leptin level in women than in men with type 1 diabetes. (PubMed id 12003376)1 Azar S.T....Zalloua P.A. (2002)
    997. Leptin in human acute myelogenous leukemia: studies of in vivo levels and in vitro effects on native functional leukemia blasts. (PubMed id 12031914)1 Bruserud O....Foss B. (2002)
    998. Novel peptide-peptide cooperation may transform feeding behavior. (PubMed id 12535698)1 Kastin A.J....Kotz C.M. (2002)
    999. Insulin and leptin combine additively to reduce food intake and body weight in rats. (PubMed id 12021212)1 Air E.L....Woods S.C. (2002)
    1000. Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. (PubMed id 12084725)1 Ambrosini G....Flores-Riveros J. (2002)
    1001. Human umbilical cord and fetal membranes co-express leptin and its receptor genes. (PubMed id 12396559)1 Akerman F....Rao C.V. (2002)
    1002. Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line. (PubMed id 12354677)1 Kaszubska W....Trevillyan J.M. (2002)
    1003. Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. (PubMed id 12482897)1 Shanley L.J....Harvey J. (2002)
    1004. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. (PubMed id 11797013)1 Minokoshi Y....Kahn B.B. (2002)
    1005. Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. (PubMed id 12149424)1 Lord G.M....Lechler R.I. (2002)
    1006. Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. (PubMed id 12100031)1 Sanchez-Margalet V....Muniain M.A. (2002)
    1007. Human follicular papilla cells carry out nonadipose tissue production of leptin. (PubMed id 11886494)1 Iguchi M....Tagami H. (2001)
    1008. A role for ghrelin in the central regulation of feeding. (PubMed id 11196643)1 Nakazato M....Matsukura S. (2001)
    1009. Human milk contains detectable levels of immunoreactive leptin. (PubMed id 11787735)1 Lyle R.E....McGehee R.E. (2001)
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    1024. Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans. (PubMed id 11443202)9 Mantzoros C.S....Licinio J. (2001)
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    1036. The inhibition of growth hormone secretion presented in obesity is not mediated by the high leptin levels: a study in human leptin deficiency patients. (PubMed id 12519870)9 Ozata M....Casanueva F.F. (2003)
    1037. Leptin and the pituitary. (PubMed id 11824510)9 Popovic V....Casanueva F.F. (2001)
    1038. Short-term fasting selectively suppresses leptin pulse mass and 24-hour rhythmic leptin release in healthy midluteal phase women without disturbing leptin pulse frequency or its entropy control (pattern orderliness). (PubMed id 10634388)9 Bergendahl M....Veldhuis J.D. (2000)
    1039. Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA. (PubMed id 10856891)9 Kauter K....McFarlane J.R. (2000)
    1040. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. (PubMed id 9100610)9 Kennedy A....Garvey W.T. (1997)
    1041. Distribution of plasma levels of adiponectin and lept in in an adult Caucasian population. (PubMed id 19473178)9 Marques-Vidal P....Vollenweider P. (2010)
    1042. Clinicopathologic significance of leptin and leptin r eceptor expressions in papillary thyroid carcinoma. (PubMed id 20045163)9 Cheng S.P....Liu C.L. (2010)
    1043. Effects of seafood consumption and weight loss on fasting leptin and ghrelin concentrations in overweight and obese European young adults. (PubMed id 19142567)9 Ramel A....Thorsdottir I. (2009)
    1044. Effects of leptin on in vitro maturation, fertilizati on and embryonic cleavage after ICSI and early developmental expression of lept in (Ob) and leptin receptor (ObR) proteins in the horse. (PubMed id 19835605)9 Lange Consiglio A....Cremonesi F. (2009)
    1045. Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin. (PubMed id 18387655)9 Eriksson M....Soderberg S. (2008)
    1046. Leptin and TNF-alpha levels in patients with chronic obstructive pulmonary disease and their relationship to nutritional parameters. (PubMed id 14872110)9 Calikoglu M....Atik U. (2004)
    1047. Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis. (PubMed id 15049957)9 Stamatiadis D.N....Mantzoros C.S. (2004)
    1048. Endocrine responses in mares and geldings with high body condition scores grouped by high vs. low resting leptin concentrations. (PubMed id 12968707)9 Cartmill J.A....Huff N.K. (2003)
    1049. Gender variation in leptin circadian rhythm and pulsatility in adult growth hormone deficiency: effects of growth hormone replacement. (PubMed id 12641632)9 White H.D....Vora J.P. (2003)
    1050. Immaturity or starvation? Longitudinal study of leptin levels in premature infants. (PubMed id 11474147)9 Spear M.L....Funanage V.L. (2001)
    1051. Leptin and its role in lipid metabolism. (PubMed id 11353336)9 Hynes G.R. and Jones P.J. (2001)
    1052. Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance. (PubMed id 10997652)9 Havel P.J. (2000)
    1053. Effect of puberty on the relationship between circulating leptin and body composition. (PubMed id 10902802)9 Horlick M.B....Leibel R.L. (2000)
    1054. Leptin inhibits testosterone secretion from adult rat testis in vitro. (PubMed id 10320818)9 Tena-Sempere M....Aguilar E. (1999)
    1055. Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry. (PubMed id 10509783)9 Schubring C....Kiess W. (1999)
    1056. The role of SOCS-3 in leptin signaling and leptin resistance. (PubMed id 10514492)9 Bjorbaek C....Flier J.S. (1999)
    1057. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. (PubMed id 9626154)9 Casabiell X....Casanueva F.F. (1998)
    1058. The effect of exercise on leptin concentration in hea lthy men and in type 1 diabetic patients. (PubMed id 9624635)9 Koistinen H.A....Koivisto V.A. (1998)
    1059. Leptin concentrations are associated with higher proinsulin and insulin concentrations but a lower proinsulin/insulin ratio in non-diabetic subjects. (PubMed id 9756249)9 Haffner S.M....Stern M.P. (1998)
    1060. Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. (PubMed id 9768648)9 Klein K.O....Hassink S.G. (1998)
    1061. [A highly sensitive enzyme-linked immunosorbent assay for measurement of leptin secretion in human adipocytes] (PubMed id 19159558)9 Li M....Wu C.Y. (2008)
    1062. Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis. (PubMed id 17509098)9 Ockenga J....Bahr M.J. (2007)
    1063. Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion. (PubMed id 16219000)9 Sahu A. and Metlakunta A.S. (2005)
    1064. Leptin and bone metabolism. (PubMed id 15293517)9 Coen G. (2004)
    1065. Leptin, obesity and cardiovascular disease. (PubMed id 15202616)9 Correia M.L. and Haynes W.G. (2004)
    1066. Evidence for a key role of leptin in osteoarthritis. (PubMed id 14613274)9 Dumond H....Pottie P. (2003)
    1067. The therapeutic potential of leptin. (PubMed id 12605561)9 Proietto J. and Thorburn A.W. (2003)
    1068. Endotoxin stimulates leptin in the human and nonhuman primate. (PubMed id 12629120)9 Landman R.E....Wardlaw S.L. (2003)
    1069. Leptin and renal disease. (PubMed id 11774095)9 Wolf G....Ziyadeh F.N. (2002)
    1070. Perspectives in the therapeutic use of leptin. (PubMed id 11825304)9 Salvador J....Fruhbeck G. (2001)
    1071. Heritability of leptin levels and the shared genetic effects on body mass index and leptin in adult Finnish twins. (PubMed id 11244469)9 Kaprio J....Tuomilehto J. (2001)
    1072. Leptin and the hypothalamic-pituitary regulation of the gonadotropin-gonadal axis. (PubMed id 11824513)9 Chan J.L. and Mantzoros C.S. (2001)
    1073. Regulation of the leptin content of obese human adipose tissue. (PubMed id 11171593)9 Russell C.D....Fried S.K. (2001)
    1074. Human leptin regulation and promise in pharmacotherapy. (PubMed id 11469718)9 Dagogo-Jack S. (2001)
    1075. Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy. (PubMed id 11336170)9 Widjaja A....Brabant G. (2001)
    1076. Effects of growth hormone on leptin metabolism and energy expenditure in hemodialysis patients with protein-calorie malnutrition. (PubMed id 11053487)9 Garibotto G....Barreca T. (2000)
    1077. Are circulating leptin and luteinizing hormone synchronized in patients with polycystic ovary syndrome? (PubMed id 10357954)9 Sir-Petermann T....Wildt L. (1999)
    1078. Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body m ass index, skinfolds, sex steroids and umbilical cord blood leptin levels. (PubMed id 9873196)9 Schubring C....Kiess W. (1998)
    1079. [The ob gene product (leptin)--a new hormone of adipose tissue] (PubMed id 9380811)9 Robaczyk M....Krzyzanowska-Swiniarska B. (1997)
    1080. High plasma levels of adipocytokines are associated w ith platelet activation in patients with coronary artery disease. (PubMed id 19954410)9 Bigalke B....Gawaz M. (2010)
    1081. Segregation of acute leptin and insulin effects in di stinct populations of arcuate proopiomelanocortin neurons. (PubMed id 20164331)9 Williams K.W....Elmquist J.K. (2010)
    1082. [Changes of serum leptin and vascular endothelial gro wth factor in children with congenital heart disease] (PubMed id 19849936)9 Zhang Y.H....Chen Q. (2009)
    1083. Comparison of adiponectin, leptin and leptin to adiponectin ratio as diagnostic marker for metabolic syndrome in older adults of Chinese major cities. (PubMed id 19181412)9 Zhuo Q....Yang X. (2009)
    1084. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. (PubMed id 18926322)9 Martin S.S....Reilly M.P. (2008)
    1085. Effects of leptin and tumor necrosis factor-alpha on degranulation and superoxide production of polymorphonuclear neutrophils from Holstein cows. (PubMed id 17339755)9 Ahmed M....Saito M. (2007)
    1086. Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. (PubMed id 17487372)9 Ray A....Cleary M.P. (2007)
    1087. Baseline leptin levels predict change in leptin levels during weight loss in obese breast cancer survivors. (PubMed id 17319860)9 Sen A....Djuric Z. (2007)
    1088. The role of leptin in leptin resistance and obesity. (PubMed id 16782141)9 Zhang Y. and Scarpace P.J. (2006)
    1089. Rethinking leptin and insulin action: therapeutic opportunities for diabetes. (PubMed id 16236542)9 Yildiz B.O. and Haznedaroglu I.C. (2006)
    1090. Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms. (PubMed id 15585586)9 Ricci M.R....Fried S.K. (2005)
    1091. Regulatory roles of leptin in reproduction and metabolism: a comparative review. (PubMed id 15927772)9 Zieba D.A....Williams G.L. (2005)
    1092. Ghrelin and leptin elevation in postoperative intra-abdominal sepsis. (PubMed id 16465060)9 Maruna P....Rosicka M. (2005)
    1093. Leptin profile in neonatal gonadotropin surge and relationship between leptin and body mass index in early infancy. (PubMed id 15751608)9 Akcurin S....Guntekin M. (2005)
    1094. Relationship of leptin concentration to gender, body mass index and age in Saudi adults. (PubMed id 15322603)9 Al-Harithy R.N. (2004)
    1095. Obesity, leptin resistance, and the effects of insulin reduction. (PubMed id 15314628)9 Lustig R.H....Velasquez-Mieyer P.A. (2004)
    1096. Adipocytokines, fat distribution, and insulin resistance in elderly men and women. (PubMed id 15472159)9 Zoico E....Zamboni M. (2004)
    1097. Interactions between serum leptin, the insulin-like growth factor-I system, and sex, age, anthropometric and body composition variables in a healthy population randomly selected. (PubMed id 12580938)9 Gomez J.M....Soler J. (2003)
    1098. Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome. (PubMed id 12805397)9 Sandhofer A....Patsch J.R. (2003)
    1099. The regulation of IGF-1 by leptin in the pig is tissue specific and independent of changes in growth hormone. (PubMed id 14505814)9 Ajuwon K.M....Spurlock M.E. (2003)
    1100. Leptin: a review of its peripheral actions and intera ctions. (PubMed id 12439643)9 Margetic S....Hill R.A. (2002)
    1101. Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of beta3-adrenergic agonists, retinoic acid, leptin and fasting. (PubMed id 12385894)9 Zhang Y....Scarpace P.J. (2002)
    1102. Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats. (PubMed id 11604238)9 Almog B....Amsterdam A. (2001)
    1103. [Study on the effects of leptin on puberty development in children] (PubMed id 11769624)9 Sun C....Wang S. (2001)
    1104. Alcohol ingestion decreases both diurnal and nocturnal secretion of leptin in healthy individuals. (PubMed id 11894976)9 Rojdmark S....Brismar K. (2001)
    1105. Leptin, cortisol, and GH secretion interactions in short normal prepubertal children. (PubMed id 11502803)9 Ghizzoni L....Bernasconi S. (2001)
    1106. Increased weight gain after ovariectomy is not a cons equence of leptin resistance. (PubMed id 11158936)9 Chen Y. and Heiman M.L. (2001)
    1107. Serum lipid and leptin concentrations in hypopituitary patients with growth hormone deficiency. (PubMed id 10849585)9 Ozbey N....Molvalilar S. (2000)
    1108. Elevated circulating leptin levels in arterial hypertension: relationship to arteriovenous overflow and extraction of leptin. (PubMed id 11099396)9 Henriksen J.H....Jensen G. (2000)
    1109. Leptin and leptin receptor expression in rat and mouse pituitary cells. (PubMed id 10614655)9 Jin L....Lloyd R.V. (2000)
    1110. A role for leptin in sexual maturation and puberty? (PubMed id 10592445)9 Kiess W....Kratzsch J. (1999)
    1111. Changes in leptin, insulin and body composition in obese children during a weight reduction program. (PubMed id 10614543)9 Reiterer E.E....Borkenstein M.H. (1999)
    1112. Leptin before and after insulin therapy in children with new-onset type 1 diabetes. (PubMed id 10323373)9 Hanaki K....Arslanian S.A. (1999)
    1113. Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal. (PubMed id 10347125)9 Henriksen J.H....Bendtsen F. (1999)
    1114. Leptin increases circulating glucose, insulin and glucagon via sympathetic neural activation in fasted mice. (PubMed id 10411242)9 AhrAcn B. and Havel P.J. (1999)
    1115. Leptin concentrations during oral glucose tolerance test (OGTT) in obese and normal weight women. (PubMed id 10411236)9 Bougoulia M....Krassas G.E. (1999)
    1116. Leptin is involved in gender-related differences in insulin sensitivity. (PubMed id 9876349)9 FernA!ndez-Real J.M....Ricart-Engel W. (1998)
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    1118. Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. (PubMed id 9274707)9 Korbonits M....Grossman A.B. (1997)
    1119. Regulation of ob gene and overexpression in obesity. (PubMed id 9436523)9 Guerre-Millo M. (1997)
    1120. Serum leptin is increased in growth hormone-deficient adults: relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year. (PubMed id 9225837)9 Fisker S....Christiansen J.S. (1997)
    1121. Leptin secretory burst mass correlates with body mass index and insulin in normal women but not in women with polycystic ovary syndrome. (PubMed id 17950108)9 Iuorno M.J....Evans W.S. (2007)
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    1123. Leptin, from fat to inflammation: old questions and new insights. (PubMed id 15642335)9 Otero M....Gualillo O. (2005)
    1124. Effects of leptin on intracellular calcium concentrations in isolated porcine somatotropes. (PubMed id 15528950)9 Glavaski-Joksimovic A....Jeftinija S. (2004)
    1125. Leptin as a marker of nutrition and cardiovascular risk in peritoneal dialysis patients. (PubMed id 12402621)9 Aguilera A....Selgas R. (2002)
    1126. Characterization of leptin binding in bovine kidney m embranes. (PubMed id 12206874)9 Margetic S....Hill R.A. (2002)
    1127. Disruption of the synchronous secretion of leptin, LH, and ovarian androgens in nonobese adolescents with the polycystic ovarian syndrome. (PubMed id 11502810)9 Veldhuis J.D....Barontini M. (2001)
    1128. [Differences in the dynamics of leptin and cortisol during the non-infectious stress reaction] (PubMed id 12448201)9 Maruna P....Chachkhiani I. (2001)
    1129. Circulating leptin and the perioperative neuroendocrinological stress response after pediatric cardiac surgery. (PubMed id 11801844)9 Modan-Moses D....Paret G. (2001)
    1130. Circadian and ultradian rhythm and leptin pulsatility in adult GH deficiency: effects of GH replacement. (PubMed id 11502770)9 Ahmad A.M....Vora J.P. (2001)
    1131. Leptin upregulates beta3-integrin expression and interleukin-1beta, upregulates leptin and leptin receptor expression in human endometrial epithelial cell cultures. (PubMed id 11822823)9 Gonzalez R.R. and Leavis P. (2001)
    1132. Intrinsic site-specific differences in the expression of leptin in human adipocytes and its autocrine effects on glucose uptake. (PubMed id 10404835)9 Zhang H.H....Eggo M.C. (1999)
    1133. Inter-organ leptin exchange in humans. (PubMed id 9642159)9 Garibotto G....Barreca T. (1998)
    1134. Ob (obese) gene expression and leptin levels in Psammomys obesus. (PubMed id 9427536)9 Walder K....Collier G.R. (1997)
    1135. Effects of gender, body composition, and menopause on plasma concentrations of leptin. (PubMed id 8784109)9 Rosenbaum M....Leibel R.L. (1996)
    1136. Alteration of PON1 Activity in Adult and Childhood Ob esity and Its Relation to Adipokine Levels. (PubMed id 20221876)9 Seres I....Paragh G. (2010)
    1137. Diet determines features of the metabolic syndrome in 6- to 14-year-old children. (PubMed id 19838999)9 Aeberli I....Zimmermann M.B. (2009)
    1138. Appetite responds to changes in meal content, whereas ghrelin, leptin, and insulin track changes in energy availability. (PubMed id 19401375)9 Borer K.T....Burant C. (2009)
    1139. Involvement of adiponectin and leptin in breast cance r: clinical and in vitro studies. (PubMed id 19661131)9 JardAc T....Vasson M.P. (2009)
    1140. Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: comparison of leptin and adiponectin. (PubMed id 18495270)9 Sugiura K....Toyoshima H. (2008)
    1141. Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor. (PubMed id 19047149)9 Saxena N.K....Sharma D. (2008)
    1142. Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus. (PubMed id 17170237)9 Canabal D.D....Routh V.H. (2007)
    1143. TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. (PubMed id 17459524)9 Romanatto T....Velloso L.A. (2007)
    1144. Ghrelin and leptin levels in patients with obsessive-compulsive disorder. (PubMed id 17597276)9 EmA1l H.M....Gecici O. (2007)
    1145. Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseases. (PubMed id 17207790)9 Elbatarny H.S....Maurice D.H. (2007)
    1146. [Origin and significance of leptin and neuropeptide Y (NPY) in amniotic fluid between the 14th and 18th weeks of gestation] (PubMed id 17206555)9 Marek S....Schmidt S. (2006)
    1147. Tumor necrosis factor alpha and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase. (PubMed id 16403817)9 Trujillo M.E....Fried S.K. (2006)
    1148. Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. (PubMed id 16324751)9 Jow G.M....Chen C.L. (2006)
    1149. Pancreatic polypeptide in obese children before and a fter weight loss. (PubMed id 16702998)9 Reinehr T....Roth C.L. (2006)
    1150. Leptin secretion in horses: effects of dexamethasone, gender, and testosterone. (PubMed id 16305819)9 Cartmill J.A....Crowley J.C. (2006)
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    1152. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. (PubMed id 16091494)9 Fatouros I.G....Mitrakou A. (2005)
    1153. Heritability of free and receptor-bound leptin in normal twins. (PubMed id 15604304)9 Jordan J....Busjahn A. (2005)
    1154. Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. (PubMed id 15805581)9 Han C....Tian B. (2005)
    1155. Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells. (PubMed id 16154199)9 Gasperi V....Maccarrone M. (2005)
    1156. Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life. (PubMed id 16188739)9 Savino F....Silvestro L. (2005)
    1157. The relationship between BMI, plasma leptin, insulin and proinsulin before and after laparoscopic adjustable gastric banding. (PubMed id 16354527)9 Ram E....Pnina V. (2005)
    1158. Leptin-resistant obese mice do not form biliary crystals on a high cholesterol diet. (PubMed id 15555610)9 Graewin S.J....Pitt H.A. (2004)
    1159. Expression of leptin and leptin receptors in gestational trophoblastic diseases. (PubMed id 15491749)9 Li R.H....Wong Y.F. (2004)
    1160. Insulin and leptin as adiposity signals. (PubMed id 14749506)9 Benoit S.C....Woods S.C. (2004)
    1161. The association between leptin and proinsulin is lost with central obesity. (PubMed id 12190889)9 SAPderberg S....Olsson T. (2002)
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    1163. Leptin levels and IgF-binding proteins in malnourished children: effect of weight gain. (PubMed id 11827758)9 Palacio A.C....Monckeberg F. (2002)
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    1166. Insulin and insulin resistance index are not independent determinants for the variation in leptin in obese children and adolescents. (PubMed id 10968481)9 Sudi K....Borkenstein M.H. (2000)
    1167. Increased leptin production in vivo and insulin cleavage by the omental adipose tissue of morbidly obese patients. (PubMed id 9579230)9 Cuatrecasas G....Foz M. (1998)
    1168. Leptin concentrations and insulin sensitivity in normoglycemic men. (PubMed id 9152742)9 Haffner S.M....Laakso M. (1997)
    1169. IGF-I, leptin and active ghrelin levels in very low b irth weight infants during the first 8 weeks of life. (PubMed id 19785636)9 Ohkawa N....Shimizu T. (2010)
    1170. Changes in body mass index, leptin and adiponectin in Japanese children during a three-year follow-up period: a population-based coh ort study. (PubMed id 19490650)9 Nishimura R....Tajima N. (2009)
    1171. Fasting hyperinsulinemia associates with increased su b-clinical inflammation in first-degree relatives normal glucose tolerant women independently of the metabolic syndrome. (PubMed id 19685554)9 Setola E....Piatti P. (2009)
    1172. Circulation free leptin in diabetic patients and its correlation to insulin level. (PubMed id 19579977)9 Mohiti J....Afkhami-Ardekani M. (2009)
    1173. Effects of a 6-month infliximab treatment on plasma l evels of leptin and adiponectin in patients with rheumatoid arthritis. (PubMed id 19563510)9 Derdemezis C.S....Kiortsis D.N. (2009)
    1174. Dihydrotestosterone and leptin regulate gonadotropin- releasing hormone (GnRH) expression and secretion in human GnRH-secreting neuro blasts. (PubMed id 19040620)9 Morelli A....Maggi M. (2009)
    1175. Concentration of adipokines in peritoneal effluent: a new marker of acute peritonitis in peritoneal dialysis patients? (PubMed id 18708547)9 Kolonko A....Wiecek A. (2008)
    1176. Variations of tumor necrosis factor-alpha, leptin and adiponectin in mid-trimester of gestational diabetes mellitus. (PubMed id 18701022)9 Gao X.L....Zhao Y. (2008)
    1177. Correlation between vascular endothelial growth facto r and leptin in children with cyanotic congenital heart disease. (PubMed id 18246735)9 Aydin H.I....Ozcan O. (2007)
    1178. Serum retinol-binding protein-4, leptin, and adiponectin concentrations are related to ectopic fat accumulation. (PubMed id 17986645)9 Perseghin G....Luzi L. (2007)
    1179. The role of leptin and ghrelin in the regulation of f ood intake and body weight in humans: a review. (PubMed id 17212793)9 Klok M.D....Drent M.L. (2007)
    1180. Plasma nitric oxide and leptin values in patients with olanzapine-induced weight gain. (PubMed id 16426639)9 Atmaca M....Ustundag B. (2007)
    1181. Determinants of sex hormone-binding globulin concentrations in a cross-sectional study of healthy men randomly selected. (PubMed id 17315082)9 Gomez J.M....Soler J. (2007)
    1182. Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition. (PubMed id 17208213)9 Haspolat K....YolbaA9 I. (2007)
    1183. Serum insulin-like growth factor-I (IGF-I) IGF binding protein-3 (IGFBP-3) and leptin levels are related to abdominal aortic intima-media thickness in macrosomic newborns. (PubMed id 17113804)9 Koklu E....Gunes T. (2007)
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    1186. Involvement of Helicobacter pylori infection in neuro-hormonal control of food intake. (PubMed id 17218760)9 Konturek P.C....Konturek S.J. (2006)
    1187. Rapid leptin elevation after initiation of olanzapine ? (PubMed id 17314489)9 Wang H.C....Lu R.B. (2006)
    1188. Expression of endothelin-1 and adrenomedullin was not altered by leptin or resistin in bovine brain microvascular endothelial cells. (PubMed id 16940707)9 Takahashi K....Murakami O. (2006)
    1189. [Serum insulin, leptin and growth hormone levels are associated with body mass index and obesity index in adolescents] (PubMed id 16786731)9 Molero-Conejo E....Campos G. (2006)
    1190. Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoA1 ratio in Asian Indian and Caucasian men and women. (PubMed id 16606459)9 Smith J....Cianflone K. (2006)
    1191. [Gender differences in adiponectin and leptin expression in epicardial and subcutaneous adipose tissue. Findings in patients undergoing cardiac surgery] (PubMed id 17194420)9 Iglesias M.J....GonzA!lez-Juanatey J.R. (2006)
    1192. Percutaneous coronary intervention increases leptin and decreases adiponectin levels. (PubMed id 17121520)9 Azar R.R....Kassab R. (2006)
    1193. Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetes. (PubMed id 16317063)9 Griffen S.C....Havel P.J. (2006)
    1194. Serum ghrelin, leptin and adiponectin levels before and after weight loss: comparison of three methods of treatment--a prospective study. (PubMed id 17132406)9 Kotidis E.V....Papavramidis S.T. (2006)
    1195. Glucose-containing peritoneal dialysis fluids regulate leptin secretion from 3T3-L1 adipocytes. (PubMed id 15814535)9 Teta D....Harris K. (2005)
    1196. Leptin concentrations in plasma and follicular fluid from prepubertal gilts as influenced by fasting, refeeding and insulin. (PubMed id 15824969)9 Govoni N....Tamanini C. (2005)
    1197. Regulation of leptin secretion from white adipocytes by insulin, glycolytic substrates, and amino acids. (PubMed id 15741239)9 Cammisotto P.G....Bukowiecki L.J. (2005)
    1198. Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line. (PubMed id 15715521)9 Benomar Y....Taouis M. (2005)
    1199. Leptin and soluble leptin receptor levels in obese children in fasting and satiety states. (PubMed id 15813609)9 Cinaz P....Gonen S. (2005)
    1200. Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease. (PubMed id 15670203)9 Diez J.J....Selgas R. (2005)
    1201. A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse. (PubMed id 15793852)9 Roy S....Cohen D.E. (2005)
    1202. Arguments raised by the recent discovery that insulin and leptin are expressed in and secreted by human ejaculated spermatozoa. (PubMed id 16274924)9 Ando S. and Aquila S. (2005)
    1203. A protective effect of adiponectin against oxidative stress in Japanese Americans: the association between adiponectin or leptin and urinary isoprostane. (PubMed id 15690313)9 Nakanishi S....Kohno N. (2005)
    1204. Hepatic leptin signaling in obesity. (PubMed id 15788447)9 Brabant G....Nave H. (2005)
    1205. Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes. (PubMed id 15531718)9 Klein J....Klein H.H. (2004)
    1206. Effects of high-intensity exercise on leptin and test osterone concentrations in well-trained males. (PubMed id 14515011)9 Kraemer R.R....Castracane V.D. (2003)
    1207. Immunoreactive ghrelin in human cord blood: relation to anthropometry, leptin, and growth hormone. (PubMed id 12352514)9 Chanoine J.P....Birmingham C.L. (2002)
    1208. The effect of gender and gestational diabetes mellitus on cord leptin concentration. (PubMed id 12237665)9 Okereke N.C....Catalano P.M. (2002)
    1209. The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments. (PubMed id 11916919)9 Cnop M....Kahn S.E. (2002)
    1210. Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study. (PubMed id 11791088)9 Cagnacci A....Volpe A. (2002)
    1211. Effect of leptin and insulin on chick embryonic muscle cells and hepatocytes. (PubMed id 11522046)9 LamosovA! D. and Zeman M. (2001)
    1212. Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance. (PubMed id 11447020)9 VanPatten S....Cohen D.E. (2001)
    1213. Decreased maternal serum leptin in pregnancies complicated by preeclampsia. (PubMed id 11336879)9 Laml T....Wagenbichler P. (2001)
    1214. Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women. (PubMed id 11248749)9 Soderberg S....Olsson T. (2001)
    1215. Maternal and fetal serum insulin-like growth factor-I (IGF-I) IGF binding protein-3 (IGFBP-3), leptin levels and early postnatal growth in infants born asymmetrically small for gestational age. (PubMed id 11592569)9 Orbak Z....GAPkA9en D. (2001)
    1216. Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. (PubMed id 11743131)9 Havel P.J. (2001)
    1217. TNFalpha and leptin inhibit basal and glucose-stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells. (PubMed id 11443501)9 Tsiotra P.C....Raptis S.A. (2001)
    1218. Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance. (PubMed id 11596667)9 Kellerer M....HAoring H.U. (2001)
    1219. Effects of pregnancy and exercise on concentrations of the metabolic markers tumor necrosis factor alpha and leptin. (PubMed id 10694328)9 Clapp J.F. and Kiess W. (2000)
    1220. The negative association between serum free testosterone and leptin is dependent on insulin-like growth factor-binding protein 1 in healthy young and middle-aged men. (PubMed id 10762293)9 Erfurth E.M. and Ahren B. (2000)
    1221. Longitudinal changes of circadian leptin, insulin and cortisol plasma levels and their correlation during refeeding in patients with anorexia nervosa. (PubMed id 10754479)9 Herpertz S....Hebebrand J. (2000)
    1222. Testosterone and leptin in older African-American men : relationship to age, strength, function, and season. (PubMed id 10954031)9 Perry H.M....Morley J.E. (2000)
    1223. Expression of a leptin receptor in immortalized gonad otropin-releasing hormone-secreting neurons. (PubMed id 10098491)9 Magni P....Motta M. (1999)
    1224. Effect of short-term testosterone treatment on leptin concentrations in boys with pubertal delay. (PubMed id 10725773)9 Adan L....Brauner R. (1999)
    1225. Testosterone and leptin in a group of Chinese with an d without diabetes. (PubMed id 11228760)9 Ng W.Y....Thai A.C. (1999)
    1226. Leptin inhibits gonadotrophin-stimulated granulosa cell progesterone production by antagonizing insulin action. (PubMed id 10357956)9 Brannian J.D....McElroy M. (1999)
    1227. Plasma leptin is not associated with insulin resistance and proinsulin in non-diabetic South Asian Indians. (PubMed id 9632122)9 Snehalatha C....Haffner S.M. (1998)
    1228. Is there a relationship between leptin and insulin sensitivity independent of obesity? A population-based study in the Indian Ocean nation of Mauritius. Mauritius NCD Study Group. (PubMed id 9504325)9 Zimmet P.Z....Fareed D. (1998)
    1229. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro. (PubMed id 8621027)9 Kolaczynski J.W....Caro J.F. (1996)
    1230. Circulating TNF-alpha and leptin levels in offspring of NIDDM patients do not correlate to individual insulin sensitivity. (PubMed id 9013754)9 Kellerer M....HAoring H.U. (1996)
    1231. Role of adiponectin and leptin on body development in infants during the first year of life. (PubMed id 20298581)9 Bozzola E....Bozzola M. (2010)
    1232. Serial plasma concentrations of adiponectin, leptin, and resistin during therapy in children with acute lymphoblastic leukemia. (PubMed id 20051777)9 Moschovi M....Papassotiriou I. (2010)
    1233. Assessment of insulin sensitivity/resistance and thei r relations with leptin concentrations and anthropometric measures in a pregnan t population with and without gestational diabetes mellitus. (PubMed id 19269197)9 Yilmaz O....Dagdelen M. (2010)
    1234. Changes in adiponectin and leptin concentrations duri ng glucocorticoid treatment: a pilot study in patients with polymyalgia rheumat ica. (PubMed id 20398023)9 Cimmino M.A....Cordera R. (2010)
    1235. Plasma leptin and adiponectin in COPD exacerbations: associations with inflammatory biomarkers. (PubMed id 19782551)9 Krommidas G....Loukides S. (2010)
    1236. Changes in nocturnal leptin and insulin concentration s in prepubertal low birth weight children after administration of the IGF-I/IG FBP-3 complex. (PubMed id 19571559)9 IA+iguez G....Cassorla F. (2009)
    1237. Can leptin and soluble leptin receptor concentrations be used in assessing the efficacy of weight reduction programme in prepubertal obese children? Preliminary report. (PubMed id 20081271)9 Gajewska J....Laskowska-Klita T. (2009)
    1238. [Prognostic value of serum TNF-alpha, IL-10, leptin a nd CRP levels in newborns with septicemia] (PubMed id 20084913)9 Cesur S....IlikAsi R. (2009)
    1239. Insulin-stimulated increase in serum leptin levels precedes and correlates with weight gain during insulin therapy in type 2 diabete s. (PubMed id 19509109)9 Aas A.M....Birkeland K.I. (2009)
    1240. Adipocytokines in systemic lupus erythematosus: relat ionship to inflammation, insulin resistance and coronary atherosclerosis. (PubMed id 19578104)9 Chung C.P....Stein C.M. (2009)
    1241. Circulating leptin and adiponectin concentrations during tumor necrosis factor blockade in patients with active rheumatoid arthritis. (PubMed id 19273452)9 Popa C....Barrera P. (2009)
    1242. Association of serum leptin and adiponectin with obesity in asthmatics. (PubMed id 19191139)9 Jang A.S....Park C.S. (2009)
    1243. Gender difference of circulating ghrelin and leptin concentrations in chronic Helicobacter pylori infection. (PubMed id 19191897)9 Chuang C.H....Yao W.J. (2009)
    1244. Leptin and leptin receptor expression in breast cance r. (PubMed id 19809565)9 Kim H.S. (2009)
    1245. Impact of a mixed strength and endurance exercise int ervention on levels of adiponectin, high molecular weight adiponectin and lepti n in breast cancer survivors. (PubMed id 19434504)9 Ligibel J.A....Mantzoros C.S. (2009)
    1246. Low circulating adiponectin and resistin, but not leptin, levels are associated with multiple myeloma risk: a case-control study. (PubMed id 18814045)9 Dalamaga M....Mantzoros C.S. (2009)
    1247. Human uraemic plasma stimulates release of leptin and uptake of tumour necrosis factor-alpha in visceral adipocytes. (PubMed id 19666662)9 Aminzadeh M.A....Vaziri N.D. (2009)
    1248. Association Between Serum Leptin and Adiponectin Levels with Risk of Insulin Resistance and Impaired Glucose Tolerance in Non-diabetic Women. (PubMed id 19419916)9 Lee C.Y....Chang C.J. (2009)
    1249. Pre- and post- prandial appetite hormone levels in no rmal weight and severely obese women. (PubMed id 19671157)9 Carlson J.J....Adams T.D. (2009)
    1250. Correlation of the leptin:adiponectin ratio with meas ures of insulin resistance in non-diabetic individuals. (PubMed id 19756488)9 Finucane F.M....Savage D.B. (2009)
    1251. Ghrelin and apolipoprotein AIV levels show opposite t rends to leptin levels during weight loss in morbidly obese patients. (PubMed id 19172368)9 Pardina E....Peinado-Onsurbe J. (2009)
    1252. [Clinical significance and changes of serum visfatin, adiponectin and leptin levels in patients with polycystic ovarian syndrome] (PubMed id 19197132)9 Wang Y. and Yu P. (2009)
    1253. Long-term plasma levels of leptin and adiponectin in Rett syndrome. (PubMed id 18710461)9 Blardi P....Hayek J. (2009)
    1254. Short-term treatment with ezetimibe, simvastatin or their combination does not alter circulating adiponectin, resistin or leptin levels in healthy men. (PubMed id 17973945)9 Gouni-Berthold I....Mantzoros C.S. (2008)
    1255. Short-term beta-adrenergic regulation of leptin, adiponectin and interleukin-6 secretion in vivo in lean and obese subjects. (PubMed id 18435774)9 Goossens G.H....Blaak E.E. (2008)
    1256. A leptin serum concentration less than 10 ng/ml is a predictive marker of outcome in patients with moderate to severe secondary peritonitis. (PubMed id 18525209)9 Bracho-Riquelme R.L....Flores-GarcA-a A.I. (2008)
    1257. Adiponectin, but not leptin or high-sensitivity C-reactive protein, is associated with blood pressure independently of general and abdominal adiposity. (PubMed id 18633174)9 Sung S.H....Chen C.H. (2008)
    1258. The serial changes of ghrelin and leptin levels and t heir relations to weight loss after laparoscopic minigastric bypass surgery. (PubMed id 18080724)9 Liou J.M....Wu M.S. (2008)
    1259. Obesity and heart rate variability in men with myocardial infarction. (PubMed id 18651384)9 Piestrzeniewicz K....Goch J.H. (2008)
    1260. The ratio of leptin to adiponectin can be used as an index of insulin resistance. (PubMed id 18191059)9 Oda N....Itoh M. (2008)
    1261. Serum leptin and ghrelin correlate with disease activity in ANCA-associated vasculitis. (PubMed id 18281689)9 KA1mpers P....Haubitz M. (2008)
    1262. Serum leptin and cholesterol values in violent and non-violent suicide attempters. (PubMed id 18155776)9 Atmaca M....Ustundag B. (2008)
    1263. Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis. (PubMed id 18945363)9 Fiorio E....Surmacz E. (2008)
    1264. The relationships of leptin, adiponectin levels and paraoxonase activity with metabolic and cardiovascular risk factors in females treated with psychiatric drugs. (PubMed id 18925326)9 Ozenoglu A....E E.E. (2008)
    1265. Comparison of STAT3 with HIF-1alpha, Ob and ObR expressions in human endometrioid adenocarcinomas. (PubMed id 18579174)9 Wincewicz A....Sulkowski S. (2008)
    1266. Serum concentrations of cortisol, interleukin 6, leptin and adiponectin predict stress induced insulin resistance in acute inflammatory reactions. (PubMed id 19087258)9 Lehrke M....Parhofer K.G. (2008)
    1267. Elevated leptin: consequence or cause of obesity? (PubMed id 17485319)9 Scarpace P.J. and Zhang Y. (2007)
    1268. Ghrelin and leptin levels in young adults with cystic fibrosis: relationship with body fat. (PubMed id 17196447)9 Stylianou C....Nousia-Arvanitakis S. (2007)
    1269. Modulation of adiponectin and leptin during refeeding of female anorexia nervosa patients. (PubMed id 17327386)9 Modan-Moses D....Kanety H. (2007)
    1270. The effect of pH-neutral peritoneal dialysis fluids on adipokine secretion from cultured adipocytes. (PubMed id 17132702)9 Teta D....Burnier M. (2007)
    1271. Leptin stimulates endogenous cholesterol synthesis in human monocytes: New role of an old player in atherosclerotic plaque formation. Leptin-induced increase in cholesterol synthesis. (PubMed id 17560160)9 KosztA!czky B....Paragh G. (2007)
    1272. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. (PubMed id 17437645)9 Komakula S....Holguin F. (2007)
    1273. Interaction between leptin and leptin receptor in gastric carcinoma: gene ontology analysis. (PubMed id 17590101)9 Wiwanitkit V. (2007)
    1274. Adipokines in human milk and risk of overweight in early childhood: a prospective cohort study. (PubMed id 18062063)9 Weyermann M....Rothenbacher D. (2007)
    1275. Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention. (PubMed id 16909130)9 Littman A.J....McTiernan A. (2007)
    1276. Modulation of circulating IGF-I and IGFBP-3 levels by hormonal regulators of energy homeostasis in obese children. (PubMed id 17286229)9 Woelfle J.F....Roth C. (2007)
    1277. Opposite effects of insulin-like molecules and leptin in coronary heart disease of type 2 diabetes Preliminary data. (PubMed id 16038995)9 Ruige J.B....Van Gaal L.F. (2006)
    1278. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. (PubMed id 16414972)9 Otero M....Gualillo O. (2006)
    1279. Sick building syndrome (SBS) and exposure to water-damaged buildings: time series study, clinical trial and mechanisms. (PubMed id 17010568)9 Shoemaker R.C. and House D.E. (2006)
    1280. Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression. (PubMed id 16144822)9 Haugen F....Drevon C.A. (2006)
    1281. Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. (PubMed id 16493121)9 Albaugh V.L....Lynch C.J. (2006)
    1282. Inflammation, obesity and cardiovascular function in African and Caucasian women from South Africa: the POWIRS study. (PubMed id 16855625)9 Schutte A.E....Malan N.T. (2006)
    1283. Fasting ghrelin does not predict food intake after short-term energy restriction. (PubMed id 16855193)9 Blom Graaf C. (2006)
    1284. Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients. (PubMed id 17167154)9 Salles N....MAcgraud F. (2006)
    1285. The effect of increased lipid intake on hormonal responses during aerobic exercise in endurance-trained men. (PubMed id 16498052)9 Christ E.R....DAccombaz J. (2006)
    1286. Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease. (PubMed id 16432373)9 Karmiris K....Kouroumalis E.A. (2006)
    1287. Leptin and ghrelin expression in adipose tissues and serum levels in gastric banding patients. (PubMed id 16684122)9 Knerr I....Horbach T. (2006)
    1288. Leptin: a potential biomarker for childhood obesity? (PubMed id 17005171)9 Venner A.A....Doyle-Baker P.K. (2006)
    1289. Association of adipocytokines (leptin, adiponectin TNF-alpha), insulin and proinsulin with diabetes--the Mumbai Obesity Project [MOP]. (PubMed id 17212015)9 Lele R.D....Gupte A. (2006)
    1290. Leptin and insulin response to long-term total parenteral nutrition depends on body fat mass. (PubMed id 16690177)9 Rifai K....Ockenga J. (2006)
    1291. Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin. (PubMed id 15946462)9 Ballantyne G.H....Modlin I.M. (2005)
    1292. Serum leptin in the development of insulin resistance and other disorders in the metabolic syndrome. (PubMed id 16170398)9 LichnovskA! R....HrebA-cek J. (2005)
    1293. Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies. (PubMed id 16135665)9 Lappas M....Rice G.E. (2005)
    1294. [The role of tumor necrosis factor alpha and leptin in obesity and insulin resistance] (PubMed id 16080843)9 Sun Q....Wang H. (2005)
    1295. Possible involvement of leptin and leptin receptor in developing gastric adenocarcinoma. (PubMed id 16437696)9 Zhao L....Shen L. (2005)
    1296. Different tumor necrosis factor-alpha-associated leptin expression in rats with dimethylnitrosamine and bile duct ligation-induced liver cirrhosis. (PubMed id 15798949)9 Lin S.Y....Sheu W.H. (2005)
    1297. Leptin, but not adiponectin, predicts stroke in males. (PubMed id 15257725)9 SAPderberg S....Olsson T. (2004)
    1298. Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. (PubMed id 15005840)9 Kontogianni M.D....Skopouli F.N. (2004)
    1299. Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity. (PubMed id 15212649)9 Tsai P.J....Chu C.H. (2004)
    1300. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. (PubMed id 15265818)9 Meier U. and Gressner A.M. (2004)
    1301. Changes in serum levels of leptin, cytokines and lipoprotein in pre-eclamptic and normotensive pregnant women. (PubMed id 15726915)9 KoAsyigit Y....Akkus Z. (2004)
    1302. Correlates of adiponectin and the leptin/adiponectin ratio in obese and non-obese children. (PubMed id 15379417)9 Diamond F.B....Eichler D. (2004)
    1303. Serum leptin levels in marasmic children and the relationship between leptin and lipid profile. (PubMed id 15331885)9 Isik Y....Okten A. (2004)
    1304. Augmentation of leptin and hypoxia-inducible factor 1alpha mRNAs in the pre-eclamptic placenta. (PubMed id 15346662)9 Iwagaki S....Tamaya T. (2004)
    1305. Hormones regulating lipid metabolism and plasma lipids in childhood obesity. (PubMed id 15543224)9 Gil-Campos M....Gil A. (2004)
    1306. Melanocortin-independent effects of leptin on hepatic glucose fluxes. (PubMed id 15364916)9 GutiAcrrez-JuA!rez R....Rossetti L. (2004)
    1307. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. (PubMed id 15229336)9 Vendrell J....Richart C. (2004)
    1308. Interactions between leptin, neuropeptide-Y and insulin with chronic diurnal fasting during Ramadan. (PubMed id 15573845)9 Kassab S....Nayar U. (2004)
    1309. Insulin and (or) dexamethasone effects on leptin prod uction and metabolic activities of ovine adipose tissue explants. (PubMed id 14620631)9 Faulconnier Y....Chilliard Y. (2003)
    1310. ACTH and alpha-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: model for a central-peripheral melanocortin-leptin pathway. (PubMed id 12644303)9 Norman D....Fabbri A. (2003)
    1311. Simultaneous measurements of serum insulin-like growth factor-I and leptin reflect the postoperative nutrition status of oral tumor patients. (PubMed id 12679166)9 Lo H.C....Tsai L.J. (2003)
    1312. Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion. (PubMed id 12657513)9 Bifulco G....Nappi C. (2003)
    1313. Ghrelin and leptin responses to food ingestion in bulimia nervosa: implications for binge-eating and compensatory behaviours. (PubMed id 14672247)9 Monteleone P....Maj M. (2003)
    1314. Relation of leptin to insulin resistance syndrome in children. (PubMed id 12972683)9 Steinberger J....Sinaiko A.R. (2003)
    1315. Vascular endothelial growth factor and leptin: regula tion in human cumulus cells and in follicles. (PubMed id 14616272)9 Abbas M.M....Benny P.S. (2003)
    1316. Microvascular permeability is related to circulating levels of tumour necrosis factor-alpha in pre-eclampsia. (PubMed id 12667958)9 Anim-Nyame N....Steer P.J. (2003)
    1317. Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function. (PubMed id 14616887)9 Iglesias P....Diez J.J. (2003)
    1318. Divergent effects of leptin on luteinizing hormone an d insulin secretion are dose dependent. (PubMed id 12626778)9 Zieba D.A....Williams G.L. (2003)
    1319. Leptin-resistant obese mice have paradoxically low biliary cholesterol saturation. (PubMed id 12947343)9 Tran K.Q....Pitt H.A. (2003)
    1320. Insulin resistance, leptin and TNF-alpha system in morbidly obese women after gastric bypass. (PubMed id 12935365)9 Molina A....GA^mez J.M. (2003)
    1321. [Serum concentration of leptin and resistin in girls during puberty] (PubMed id 14674154)9 Kulik-Rechberger B. and Rechberger T. (2003)
    1322. Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. (PubMed id 12890276)9 Atmaca M....Ustundag B. (2003)
    1323. Serum leptin and cholesterol levels in patients with bipolar disorder. (PubMed id 12566933)9 Atmaca M....Bayik Y. (2002)
    1324. Glucocorticoid-regulated adipose tissue secretion of PAI-1, but not IL-6, TNFalpha or leptin in vivo. (PubMed id 12660885)9 UddAcn J....Hoffstedt J. (2002)
    1325. Pronounced early increase in circulating leptin predi cts a lower weight gain during clozapine treatment. (PubMed id 12172344)9 Monteleone P....Maj M. (2002)
    1326. Newborn birth weight correlates with placental zinc, umbilical insulin-like growth factor I, and leptin levels in preeclampsia. (PubMed id 11825630)9 DA-az E....Larrea F. (2002)
    1327. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. (PubMed id 12379472)9 Okumura M....Yasuda K. (2002)
    1328. Plasma leptin and the cholesterol saturation of bile are correlated in obese women after weight loss. (PubMed id 12163661)9 MAcndez-SA!nchez N....Uribe M. (2002)
    1329. Increased adipose tissue secretion of interleukin-6, but not of leptin, plasminogen activator inhibitor-1 or tumour necrosis factor alpha, in Graves' hyperthyroidism. (PubMed id 11980614)9 Wahrenberg H....Hoffstedt J. (2002)
    1330. Transcriptional regulation of the leptin promoter by insulin-stimulated glucose metabolism in 3t3-l1 adipocytes. (PubMed id 11341758)9 Moreno-Aliaga M.J....Havel P.J. (2001)
    1331. Control of the expression of human neuropeptide Y by leptin: in vitro studies. (PubMed id 11287096)9 Magni P....Motta M. (2001)
    1332. Oestradiol plus progesterone treatment increases serum leptin concentrations in normal women. (PubMed id 11527883)9 Messinis I.E....Seferiadis K. (2001)
    1333. Improved glycemic control increases fasting plasma acylation-stimulating protein and decreases leptin concentrations in type II diabetic subjects. (PubMed id 11502793)9 Ozata M....Ozdemir I.C. (2001)
    1334. Serum leptin, IGF-I and insulin levels in preterm infants receiving parenteral nutrition during the first week of life. (PubMed id 11327377)9 Park M.J....Kim D.H. (2001)
    1335. Neuropeptide Y, leptin, and cholecystokinin 8 in patients with advanced cancer and anorexia: a North Central Cancer Treatment Group exploratory investigation. (PubMed id 11505408)9 Jatoi A....Windschitl H.E. (2001)
    1336. Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor. (PubMed id 10666158)9 Finck B.N. and Johnson R.W. (2000)
    1337. Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients. (PubMed id 10841005)9 Fernandez-Real J.M....Richart C. (2000)
    1338. Microsatellites proximal to leptin and leptin receptor as risk factors for spina bifida. (PubMed id 10661913)9 Shaw G.M....Finnell R.H. (2000)
    1339. The relationship of the levels of leptin, insulin-like growth factor-I and insulin in cord blood with birth size, ponderal index, and gender difference. (PubMed id 10714754)9 Yang S.W. and Kim S.Y. (2000)
    1340. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. (PubMed id 10999830)9 Bastard J.P....Hainque B. (2000)
    1341. Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture. (PubMed id 10871189)9 Bornstein S.R....Scherbaum W.A. (2000)
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