Aliases for LEP Gene
External Ids for LEP Gene
Previous HGNC Symbols for LEP Gene
Previous GeneCards Identifiers for LEP Gene
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]
GeneCards Summary for LEP Gene
LEP (Leptin) is a Protein Coding gene. Diseases associated with LEP include leptin deficiency and congenital leptin deficiency. Among its related pathways are Signaling by GPCR and Developmental Biology. GO annotations related to this gene include growth factor activity and peptide hormone receptor binding.
UniProtKB/Swiss-Prot for LEP Gene
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass
Leptin was initially thought to have a role in energy homeostasis and obesity. It acts via leptin receptors (Ob-Rs), which are transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. There are six isoforms of Ob-R.