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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LEP Gene

protein-coding   GIFtS: 68
GCID: GC07P127881

Leptin

(Previous names: leptin (murine obesity homolog), leptin (obesity homolog,...)
(Previous symbols: OBS, OB)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
leptin1 2     Obese Protein2 3
OB1 2 3 5     Obesity Factor2 3
OBS1 2 3     LEPD2
Leptin (Murine Obesity Homolog)1 2     Obese, Mouse, Homolog Of2
Leptin (Obesity Homolog, Mouse)1 2     

External Ids:    HGNC: 65531   Entrez Gene: 39522   Ensembl: ENSG000001746977   OMIM: 1641605   UniProtKB: P411593   

Export aliases for LEP gene to outside databases

Previous GC identifers: GC07P126358 GC07P127421 GC07P127435 GC07P127475 GC07P127668 GC07P122242


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LEP Gene:
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation
of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway
that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This
protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory
responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions
cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes
mellitus development. (provided by RefSeq, Jul 2008)

GeneCards Summary for LEP Gene: 
LEP (leptin) is a protein-coding gene. Diseases associated with LEP include morbid obesity, and leptin deficiency, and among its related super-pathways are Axon guidance and Development Leptin signaling via PI3K-dependent pathway. GO annotations related to this gene include growth factor activity and peptide hormone receptor binding.

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159
Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An
increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate
energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

summary for LEP Gene:
Leptin was initially thought to have a role in energy homeostasis and obesity. More recently, it has also
been implicated in the regulation of reproduction, glucose homeostasis, bone formation, wound healing and
the immune system. Leptin acts via leptin receptors, which are transmembrane catalytic receptors found on
NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one
human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at
physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so
through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates
transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid
expression. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese
individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier)
expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are
of great interest in the development of pharmacological treatments for obesity.

Gene Wiki entry for LEP (Leptin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LEP gene promoter:
         GR   C/EBPbeta   AP-1   ATF-2   GR-beta   AP-2gamma   AREB6   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): LEP promoter sequence
   Search SABiosciences Chromatin IP Primers for LEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q31

LEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LEP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P127881:  view genomic region     (about GC identifiers)

Start:
127,881,331 bp from pter      End:
127,897,682 bp from pter
Size:
16,352 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 127,264,455-127,280,803     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LEP_HUMAN, P41159 (See protein sequence)
Recommended Name: Leptin precursor  
Size: 167 amino acids; 18641 Da
Subunit: Interacts with SIGLEC6
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for LEP:
1AX8 (3D)    
Secondary accessions: O15158 Q56A88

Explore the universe of human proteins at neXtProt for LEP: NX_P41159

Explore proteomics data for LEP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41159

  • LEP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LEP Protein Expression
    REFSEQ proteins: NP_000221.1  
    ENSEMBL proteins: 
     ENSP00000312652  
    Reactome Protein details: P41159
    Human Recombinant Protein Products for LEP: 
    EMD Millipore Purified and/or Recombinant LEP Protein
    R&D Systems Recombinant & Natural Proteins for LEP (Leptin/OB)
    Enzo Life Sciences proteins for LEP
    OriGene Purified Protein for LEP
    OriGene Protein Over-expression Lysate for LEP
    OriGene MassSpec for LEP 
    OriGene Custom Protein Services for LEP
    GenScript Purified and Recombinant Proteins for LEP
    Novus Biologicals LEP Proteins
    Novus Biologicals LEP Lysate
    Sino Biological Recombinant Protein for LEP
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for LEP
    Cloud-Clone Corp. Proteins for LEP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm IEA--

    LEP for ontologies           About GeneDecksing



    LEP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LEP
    R&D Systems Antibodies for LEP (Leptin/OB)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LEP
    GenScript Superior Antibodies for LEP
    Novus Biologicals LEP Antibodies
    Abcam antibodies for LEP
    Cloud-Clone Corp. Antibodies for LEP 
    ThermoFisher Antibody for LEP
    LSBio Antibodies in human, mouse, rat for LEP 

    Assay Products for LEP: 
    EMD Millipore Kits and Assays for the Analysis of LEP
    OriGene Custom Assay Services for LEP
    R&D Systems ELISAs for LEP (Leptin/OB)         (see all)
    GenScript Custom Assay Services for LEP
    Enzo Life Sciences assays for LEP
    Cloud-Clone Corp. ELISAs for LEP 
    Cloud-Clone Corp. CLIAs for LEP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR009079 4_helix_cytokine-like_core
     IPR012351 4_helix_cytokine_core
     IPR000065 Leptin

    Graphical View of Domain Structure for InterPro Entry P41159

    ProtoNet protein and cluster: P41159

    1 Blocks protein domain: IPB000065 Obesity factor (leptin) signature

    UniProtKB/Swiss-Prot: LEP_HUMAN, P41159
    Similarity: Belongs to the leptin family


    LEP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEP_HUMAN, P41159
    Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An
    increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate
    energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

         Genatlas biochemistry entry for LEP:
    leptin,adipocyte-specific secreted protein,18.6kDa,controlling the size of adipose depot by a profound effect of
    appen appetite and energy expenditure,also involved in control of the hypothalamic-pituitary-gonadal (HPG)
    axis,also putative angiogenic factor,homolog of the murine obese gene (ob)

         Summary:
    During embryonic development, LEP as signaling molecule is secreted from the following cells: Subcutaneous White Adipocytes in Subcutaneous White Adipose, Subcutaneous White Adipocytes in Body Subcutaneous White Adipose (see all 6).

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0051428peptide hormone receptor binding IEA--
         
    LEP for ontologies           About GeneDecksing


    Phenotypes:
         15/24 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Lep) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    LEP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LEP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LEP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LEP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LEP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LEP
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate LEP (see all 24):
    hsa-miR-498 hsa-miR-29a hsa-miR-29c hsa-miR-128 hsa-miR-27b* hsa-miR-9 hsa-miR-1276 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidLEP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LEP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LEP
    Sirion Biotech Customized adenovirus for overexpression of LEP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LEP (see all 7)
    OriGene ORF clones in mouse, rat for LEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LEP (NM_000230)
    Sino Biological Human cDNA Clone for LEP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEP
    Sirion Biotech Customized lentivirus for stable overexpression of LEP 
                         Customized lentivirus expression plasmids for stable overexpression of LEP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LEP
    Search LifeMap BioReagents cell lines for LEP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LEP About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Developmental Biology0.69
    2Development Leptin signaling via PI3K-dependent pathway
    Development Leptin signaling via PI3K-dependent pathway1.00
    3Development Leptin signaling via JAK/STAT and MAPK cascades
    Development Leptin signaling via JAK/STAT and MAPK cascades1.00
    4PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    5Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for LEP
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Selected targets of GCR-alpha
    Development Leptin signaling via PI3K-dependent pathway

    1 R&D Systems Pathway for LEP
        Adipocytokines & Insulin Signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LEP
        AMPK Enzyme Complex Pathway

    2 GeneGo (Thomson Reuters) Pathways for LEP
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development Leptin signaling via PI3K-dependent pathway

    5/6 BioSystems Pathways for LEP (see all 6)
        Adipogenesis
    AMPK signaling
    Spinal Cord Injury
    Leptin signaling pathway
    Signaling events mediated by PTP1B


    2        Reactome Pathways for LEP
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation


    5         Kegg Pathways  (Kegg details for LEP):
        Cytokine-cytokine receptor interaction
    Neuroactive ligand-receptor interaction
    Jak-STAT signaling pathway
    Adipocytokine signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)


    LEP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for LEP (P411593 ENSP000003126524) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAA2P546463, ENSP000003602904I2D: score=1 STRING: ENSP00000360290
    UCNP550893, ENSP000002960994I2D: score=1 STRING: ENSP00000296099
    LEPRP483573, ENSP000003303934I2D: score=2 STRING: ENSP00000330393
    A2MP010233, ENSP000003239294I2D: score=2 STRING: ENSP00000323929
    CRPP027413, ENSP000002550304I2D: score=1 STRING: ENSP00000255030
    About this table

    Gene Ontology (GO): 5/59 biological process terms (GO ID links to tree view) (see all 59):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001542ovulation from ovarian follicle IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001819positive regulation of cytokine production IEA--
    GO:0001890placenta development IDA17957153

    LEP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LEP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for LEP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LEP (116-130) (mouse)Synthetic leptin peptide fragment[258276-95-8]

    1 HMDB Compound for LEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Androstenedione(4)-Androsten-3,17-dione (see all 14)63-05-811824514

    130 Novoseek inferred chemical compound relationships for LEP gene (see top 10)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 84.8 1892 10411236 (8), 10411242 (8), 17170237 (7), 15814535 (6) (see all 99)
    c-peptide 71.5 169 12752073 (4), 16365005 (4), 19475640 (4), 15196417 (4) (see all 99)
    lipid 70.7 531 16737635 (6), 15543224 (5), 11502793 (5), 19169663 (4) (see all 99)
    testosterone 70.6 677 18462615 (11), 11244464 (9), 9253326 (7), 11228760 (6) (see all 99)
    cholesterol 70.4 648 15555610 (7), 16324751 (7), 11447020 (6), 17884293 (6) (see all 99)
    estradiol 67.6 321 9768648 (9), 11791088 (6), 9482922 (5), 11599235 (4) (see all 99)
    dehydroepiandrosterone sulfate 63.4 91 10561001 (3), 12647279 (3), 11820328 (2), 17198487 (2) (see all 52)
    orlistat 61.4 19 18846024 (3), 20119816 (2), 19409578 (2), 18457636 (1) (see all 6)
    fatty acid 61 162 16822822 (4), 11342529 (3), 11404229 (3), 15919610 (3) (see all 99)
    metformin 59.5 71 15531718 (6), 11436194 (4), 15983226 (3), 11289473 (3) (see all 37)
    sibutramine 56.5 14 16380708 (4), 11474475 (2), 11929078 (1), 18457636 (1) (see all 9)
    triiodothyronine 55.9 75 18613985 (2), 10024085 (2), 18029480 (2), 16213991 (2) (see all 51)
    nash 55.7 30 19861844 (4), 14687831 (3), 17086867 (2), 18609175 (2) (see all 19)
    alpha msh 52.1 7 11068094 (2), 10612703 (1), 19457101 (1), 15481810 (1) (see all 5)
    thyroxine 50.9 83 10921449 (3), 14677867 (3), 12875743 (2), 18613985 (2) (see all 57)
    olanzapine 50.3 73 16426639 (6), 17314489 (6), 16204328 (4), 11314683 (4) (see all 24)
    rosiglitazone 50.2 23 12502492 (3), 16579998 (2), 18394743 (2), 15741250 (2) (see all 16)
    androstenedione 49.7 55 11502810 (4), 11078990 (3), 15194576 (3), 18401941 (3) (see all 33)
    gnrh 48.1 135 10098491 (6), 19040620 (6), 11008348 (5), 16038631 (4) (see all 53)
    acth 48.1 120 12644303 (5), 16684834 (4), 15763583 (4), 11824511 (4) (see all 66)
    triacylglycerol 48 53 11404229 (3), 14710168 (2), 19169663 (2), 17656596 (2) (see all 36)
    enterostatin 45.6 2 9344422 (1), 9208352 (1)
    progesterone 45.4 189 16154199 (7), 19849856 (6), 17154301 (6), 10357956 (6) (see all 88)
    troglitazone 41.6 40 10946865 (5), 11092516 (5), 8772734 (4), 12351424 (3) (see all 13)
    oxyntomodulin 40 2 17542673 (1), 16340035 (1)
    estrone 39.8 28 10352949 (4), 17667144 (2), 9626154 (2), 17145648 (2) (see all 19)
    beta-hydroxybutyrate 39.3 26 11375799 (2), 18246527 (2), 12519869 (1), 12566146 (1) (see all 18)
    uric acid 39.2 82 12906034 (4), 19025443 (4), 12238635 (4), 12953019 (4) (see all 46)
    thiazolidinedione 38.9 1 12660870 (1)
    pioglitazone 38.9 17 16373904 (2), 16118250 (1), 9287037 (1), 19040587 (1) (see all 13)
    estrogen 38.9 158 9291839 (4), 14985328 (4), 15475434 (3), 16127214 (3) (see all 85)
    carbohydrates 38.6 21 11250666 (1), 12392446 (1), 17517446 (1), 10595593 (1) (see all 15)
    wortmannin 36.5 22 12657249 (2), 18501560 (2), 12411472 (1), 16684834 (1) (see all 17)
    rimonabant 35 7 16924165 (1), 18480689 (1), 18457636 (1), 17369778 (1) (see all 6)
    clozapine 34.5 40 12172344 (5), 11775042 (4), 12755665 (3), 11314683 (3) (see all 16)
    dexamethasone 33 176 16305819 (7), 9506746 (6), 10946865 (6), 9666874 (6) (see all 59)
    dhea 32.9 41 9666874 (4), 11820328 (2), 10692080 (2), 17236585 (2) (see all 23)
    phosphatidylinositol 32.7 48 14715711 (3), 16684834 (2), 11756337 (2), 16219000 (2) (see all 36)
    pramlintide 32.3 7 20029268 (2), 19885278 (1), 18458326 (1), 19521351 (1)
    glycerol 3-phosphate 32.2 13 17880164 (1), 10687854 (1), 18448614 (1), 19254366 (1) (see all 9)
    shu 9119 31.4 1 19394382 (1)
    11beta-hydroxysteroid 31.1 4 19218882 (1), 17060929 (1), 15220243 (1), 16621515 (1)
    tibolone 30.5 20 18249383 (3), 14974912 (2), 11138402 (2), 15172084 (1) (see all 8)
    p002 29.9 18 17187880 (1), 15964536 (1), 10633217 (1), 10557022 (1) (see all 16)
    fibrinogen 29.4 83 16855625 (5), 18160070 (4), 19739579 (3), 16732378 (3) (see all 53)
    pd 98,059 29.4 20 17991320 (3), 12657249 (2), 12411472 (1), 14715711 (1) (see all 14)
    fenfluramine 29.2 4 11780443 (1), 11798925 (1)
    p003 29.2 14 10968480 (2), 10633217 (1), 10905584 (1), 12476932 (1) (see all 11)
    acipimox 29.2 11 12176665 (4), 11022182 (2), 10726911 (2)
    steroid 28.6 79 16684834 (3), 10098510 (3), 11820328 (2), 11281366 (2) (see all 58)
    norepinephrine 28.6 117 11786145 (4), 11411732 (4), 12953019 (4), 10912765 (4) (see all 55)
    8-isoprostane 26.3 24 16784964 (4), 19570342 (4), 17495192 (2), 12387653 (2) (see all 11)
    vegf 26.1 160 19849936 (8), 20396799 (6), 18246735 (6), 14616272 (5) (see all 67)
    cocaine 26 40 16210367 (2), 12832094 (2), 11508653 (1), 11729633 (1) (see all 32)
    glycerol 25.3 24 18246527 (3), 18389092 (2), 12600841 (1), 14710168 (1) (see all 19)
    ly294002 22.9 8 16912864 (1), 11756337 (1), 15166121 (1), 14715711 (1) (see all 7)
    risperidone 21.7 17 12755665 (3), 15737248 (2), 19873684 (2), 12366389 (2) (see all 8)
    intralipid 20.6 5 12773140 (2), 10868951 (1)
    megestrol acetate 19.9 5 12586855 (2), 12734062 (2)
    aicar 19.7 9 18801339 (1), 14500570 (1), 16822822 (1), 17170237 (1) (see all 6)
    25-hydroxyvitamin d 18 10 19858320 (3), 20350696 (1), 14582047 (1), 19863876 (1) (see all 8)
    6-diazo-5-oxo-l-norleucine 18 2 15814535 (1), 11061500 (1)
    anandamide 17.4 8 12556536 (3), 16154199 (2), 12799380 (1), 20426869 (1) (see all 5)
    oleoyl-estrone 15.4 7 10352949 (6), 12166825 (1)
    creatinine 15.2 79 10668953 (3), 12906034 (2), 12807502 (2), 16709438 (2) (see all 58)
    corticosterone 14.3 62 11824511 (6), 12166825 (6), 11903416 (4), 14980794 (4) (see all 27)
    2-arachidonoylglycerol 13.9 2 19528974 (1), 15841111 (1)
    cortisone 13.9 2 17426324 (1), 12646713 (1)
    topiramate 11 5 19205363 (1), 18670246 (1), 16034698 (1), 20207521 (1)
    dihydrotestosterone 11 13 10076188 (3), 16899222 (1), 12374466 (1), 19040620 (1) (see all 7)
    fenofibrate 10.2 4 15291748 (3), 8770873 (1)
    epinephrine 9.63 53 16454443 (4), 11786596 (4), 10480609 (3), 11311882 (3) (see all 30)
    cetrorelix 8.17 4 10612483 (4)
    letrozole 6.66 2 15328175 (1), 12374466 (1)
    exenatide 5.68 1 16534527 (1)
    arginine 5.28 12 18689498 (2), 9439547 (2), 12559482 (1), 12398234 (1) (see all 9)
    n acetylcysteine 5.02 4 12882931 (1), 18284032 (1)
    citalopram 5.01 6 16335904 (3), 12581014 (2)
    etanercept 4.86 3 17374698 (3)
    thiopental 4.04 1 11167167 (1)
    n(g)-nitro-l-arginine methyl ester 3.93 4 10864886 (1), 12226143 (1), 12270147 (1)
    betacarotene 3.81 2 17023700 (1), 16154553 (1)
    l-nmma 3.76 9 12627874 (2), 10781383 (1), 16543250 (1)
    capsaicin 3.64 1 17295509 (1)
    paroxetine 3.58 2 10869882 (1), 16643914 (1)
    vitamin a 3.21 16 20209828 (2), 18194136 (2), 11825548 (1), 16891032 (1) (see all 14)
    indomethacin 3.2 8 10381155 (2), 10873674 (1), 18340408 (1), 12644303 (1) (see all 6)
    atenolol 3.19 2 19059660 (1), 20069551 (1)
    stavudine 3.08 1 18215977 (1)
    pravastatin 2.72 12 15988706 (3), 19050671 (2), 9863278 (1), 11836282 (1) (see all 8)
    butyrate 2.7 8 14752104 (4), 12034734 (3)
    cycloheximide 2.66 2 15585586 (1)
    losartan 2.38 3 11881109 (2), 17950096 (1)
    ribavirin 2.32 2 17451564 (1), 11336170 (1)
    alpha tocopherol 2.2 2 10389004 (1), 16154553 (1)
    hyaluronic acid 2.06 8 17086867 (2), 18997286 (2), 16911470 (1)
    naloxone 2.03 4 10718909 (2), 9806577 (1)
    inositol 1.97 4 15206484 (1), 10833332 (1), 18074942 (1)
    sodium nitroprusside 1.95 1 12970164 (1)
    acetylcholine 1.76 12 11744348 (2), 15749744 (2), 15894577 (2), 12806215 (1) (see all 7)
    ganciclovir 1.62 1 11786145 (1)
    adenine 1.62 5 17070518 (3)
    ibuprofen 1.51 1 9728566 (1)
    ascorbic acid 1.26 2 12237663 (1), 14632197 (1)
    prostacyclin 0.973 4 12468269 (2), 20514986 (2)
    paraffin 0.715 2 12943068 (1), 14641693 (1)
    nicotine 0.714 20 10093001 (4), 15964536 (3), 9750463 (2), 10696640 (1) (see all 5)
    methotrexate 0.683 5 19156421 (3), 12972473 (1)
    serine 0.622 6 19208634 (1), 17208384 (1), 14532024 (1), 15358050 (1) (see all 6)
    phenylephrine 0.601 2 10873674 (2)
    nifedipine 0.587 1 15528950 (1)
    glutamate 0.574 19 14657608 (3), 9705575 (2), 16609702 (2), 15858953 (2) (see all 11)
    nmda 0.553 28 16413128 (3), 11734601 (3), 16086687 (3), 19076377 (1) (see all 8)
    gaba 0.362 1 14557794 (1)
    h2o2 0.134 9 16173077 (3), 16996477 (2), 18282556 (1), 14567439 (1) (see all 6)
    heparin 0.12 7 12773140 (2), 10868951 (1), 10726911 (1), 17952842 (1)
    cysteine 0.102 7 15840566 (1), 9013735 (1), 14629116 (1), 19293295 (1) (see all 6)
    cisplatin 0.0718 1 17363502 (1)
    cyclosporin a 0.0476 3 18700169 (1)
    telmisartan 0 5 17345784 (2), 20449538 (2), 17240472 (1)
    tamoxifen 0 9 19771272 (2), 15328175 (1), 15542935 (1), 10924844 (1) (see all 7)
    clonidine 0 6 15778926 (3), 17127827 (1), 12816347 (1), 17008857 (1)
    glibenclamide 0 4 18831351 (2), 10873674 (1), 12679437 (1)
    quetiapine 0 6 12755665 (3), 14716710 (1), 16761509 (1)
    clenbuterol 0 3 16531894 (2), 16157516 (1)
    aminoguanidine 0 2 15899045 (1), 16442319 (1)
    lamivudine 0 1 16091072 (1)
    budesonide 0 1 10464891 (1)
    sulpiride 0 4 10855458 (2)
    rapamycin 0 13 19020099 (3), 19628573 (2), 18653778 (2), 18798554 (1) (see all 9)

    2 PharmGKB related drug/compound annotations for LEP gene    About this table
    Drug/compound PharmGKB Annotation
    olanzapineCA  
    risperidoneCA  

    Search CenterWatch for drugs/clinical trials and news about LEP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LEP gene: 
    NM_000230.2  

    Unigene Cluster for LEP:

    Leptin
    Hs.194236  [show with all ESTs]
    Unigene Representative Sequence: NM_000230
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000308868(uc003vml.2 uc003vmm.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate LEP (see all 24):
    hsa-miR-498 hsa-miR-29a hsa-miR-29c hsa-miR-128 hsa-miR-27b* hsa-miR-9 hsa-miR-1276 hsa-miR-298
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    Additional mRNA sequence: 

    AF008123.1 AK313553.1 BC060830.1 BC069323.1 BC069452.1 BC069527.1 D49487.1 U18915.1 
    U43653.1 

    1 DOTS entry:

    DT.412760 

    24/25 AceView cDNA sequences (see all 25):

    BQ012637 U18915 U43653 BC069527 BX098617 BC069323 BU752306 NM_000230 
    BC069452 R62951 BC060830 BX479630 AF008123 AA320865 R63003 BQ019411 
    CB995210 N56684 D49487 H42529 H39701 H42528 CB265926 CB995927 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LEP    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for LEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LEP expression in normal human tissues (normalized intensities)      LEP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAGGGAC
    LEP Expression
    About this image


    LEP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 17 entries
             Visceral White Adipocytes Visceral White Adipose
             Body Subcutaneous White Adipose
             omental adipose tissue   
     
     Hair
             Human Hair Outer Root Sheath Cells (HHORSC)   
     
     Bone (Muscoskeletal System)
             Notch-transfected mesenchymal stromal cells (SB623)
     
     Mesenchymal Stem Cells
             Notch-transfected mesenchymal stromal cells (SB623)
     
     Dermis (Integumentary System)
             Human Hair Outer Root Sheath Cells (HHORSC)   

    See LEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LEP

    SOURCE GeneReport for Unigene cluster: Hs.194236
        SABiosciences Expression via Pathway-Focused PCR Arrays including LEP (see all 10): 
              Insulin Signaling Pathway in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Angiogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for LEP gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lep1 , 5 leptin1, 5 82.63(n)1
    83.23(a)1
      6 (12.30 cM)5
    168461  NM_008493.31  NP_032519.11 
     290602205 


    ENSEMBL Gene Tree for LEP (if available)
    TreeFam Gene Tree for LEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/616 SNPs in LEP are shown (see all 616)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048940231,2,4
    CLeptin deficiency (LEPD)4 pathogenic1131237807(+) ACCTCC/TGGGAT 2 R W mis10--------
    rs668186461,2
    C--127267454(-) TAATC-/TG/   
      TGTGTG
    TGTGT
    1 -- int12NA 4
    rs106764011,2
    C,F--127882006(+) AATGA-/AAT   
      G
    /ATGA
    GGTGT
    1 -- int12NS 92
    rs113804671,2
    C--127884139(+) AAAAAA/-GTAAC 1 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    rs674586951,2
    C--127884300(+) CACAC-/ACAC  
            
    ACACA
    1 -- int10--------
    rs1447140621,2
    C--127884300(+) CCCTG-/ACACACAC
    ACACACACAC
    ACACA
    1 -- int10--------
    rs1473316701,2
    C--127884300(+) CCCTG-/ACACAC
            
    ACACA
    1 -- int10--------
    rs1887896531,2
    --131222519(+) GAATGC/TCTATC 1 -- us2k10--------
    rs7916161,2
    C,F,A,H--131222528(+) tcctaC/Tgcaat 1 -- us2k17Minor allele frequency- T:0.06EA NS NA WA 540
    rs611535761,2
    C,F--131222529(+) CCTACG/ACAATG 1 -- us2k12Minor allele frequency- A:0.11WA 120

    HapMap Linkage Disequilibrium report for LEP (127881331 - 127897682 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LEP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33413CNV Gain17666407


    Human Gene Mutation Database (HGMD): LEP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LEP
    DNA2.0 Custom Variant and Variant Library Synthesis for LEP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164160    OMIM disorders: --

    UniProtKB/Swiss-Prot: LEP_HUMAN, P41159
  • Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe
    hyperphagia and intractable obesity from an early age. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 20/261 diseases for LEP (see all 261):    About MalaCards
    morbid obesity    leptin deficiency    diencephalic syndrome    monogenic non-syndromic obesity, autosomal recessive
    sleep apnea    overnutrition    nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency    lipoatrophic diabetes
    lipoblastoma    fetal macrosomia    acquired generalized lipodystrophy    obesity
    metabolic syndrome x    skin tag    alstrom syndrome    sick building syndrome
    anorexia nervosa    bulimia nervosa    hypogonadism    rabson-mendenhall syndrome

    20/23 diseases from the University of Copenhagen DISEASES database for LEP (see all 23):
    Diabetes mellitus     Hyperinsulinism     Morbid obesity     Hypertension
    Hyperglycemia     Lipodystrophy     Fatty liver disease     Polycystic ovary syndrome
    Atherosclerosis     Eating disorder     Amenorrhea     Hypogonadism
    Infertility     Heart disease     Osteoporosis     Kidney failure
    Prader-Willi syndrome     Breast cancer     Rabies     Hyperandrogenism

    LEP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for LEP gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 93.7 2301 10722859 (6), 16782141 (6), 15793852 (6), 17147067 (5) (see all 99)
    insulin resistance 91.6 952 17093174 (6), 18521457 (5), 19781705 (5), 12485522 (5) (see all 99)
    insulin sensitivity 87.1 401 9876349 (8), 9385530 (5), 17413885 (4), 19269197 (4) (see all 99)
    hyperinsulinemia 79.1 151 17236585 (4), 9820061 (3), 17085442 (3), 15855322 (2) (see all 99)
    anorexia nervosa 78 154 17304762 (7), 11919545 (4), 9169091 (4), 9177394 (3) (see all 97)
    lipodystrophy 73.7 107 19727665 (5), 11856796 (4), 18348717 (4), 15356018 (3) (see all 51)
    polycystic ovary syndrome 72.9 112 11502810 (8), 12921548 (2), 17062953 (2), 18756827 (2) (see all 72)
    acquired generalized lipodystrophy 70.5 4 15256772 (1), 18076675 (1), 11994394 (1), 12502655 (1)
    lipodystrophy, congenital generalized 69.4 19 17118991 (4), 15983199 (3), 11994394 (2), 12502655 (2) (see all 12)
    niddm 68.3 128 2010535 (6), 8636448 (3), 9283801 (3), 8621021 (3) (see all 70)

    Genetic Association Database (GAD): LEP
    Human Genome Epidemiology (HuGE) Navigator: LEP (162 documents)

    Export disorders for LEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LEP gene, integrated from 9 sources (see all 4574):
    (articles sorted by number of sources associating them with LEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. (PubMed id 8621021)1, 2, 4, 9 Niki T.... Kasuga M. (1996)
    2. Genotype x nutrient association of common polymorphis ms in obesity-related genes with food preferences and time structure of energy intake. (PubMed id 19747414)1, 4, 9 BienertovA!-VaskA^ J....VaskA^ A. (2010)
    3. Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. (PubMed id 19697123)1, 4, 9 Cleveland R.J....Santella R.M. (2009)
    4. Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. (PubMed id 18564365)1, 4, 9 Han H....Park K. (2008)
    5. Leptin gene (TTTC)(n) microsatellite polymorphism as well as leptin receptor R223Q and PPARgamma2 P12A substitutions are not associa ted with hypertensive disorders in pregnancy. (PubMed id 20070288)1, 4, 9 Wiedemann A....Toth B. (2010)
    6. Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. (PubMed id 19337797)1, 4, 9 BienertovA!-VaskA^ J.A....VaskA^ A. (2009)
    7. Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins. (PubMed id 18490929)1, 4, 9 Souren N.Y....Zeegers M.P. (2008)
    8. Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. (PubMed id 18716353)1, 4, 9 Mizuta E....Morisaki T. (2008)
    9. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. (PubMed id 16504019)1, 4, 9 Snoussi K....Chouchane L. (2006)
    10. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. (PubMed id 15760495)1, 4, 9 Poitou C....Clement K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3952 HGNC: 6553 AceView: LEP Ensembl:ENSG00000174697 euGenes: HUgn3952
    ECgene: LEP Kegg: 3952 H-InvDB: LEP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LEP Pharmacogenomics, SNPs, Pathways
    R&D Systems' cytokine mini-reviews: Leptinhttp://www.rndsystems.com/molecule_detail.aspx?m=1773
    Wikipedia http://en.wikipedia.org/wiki/Leptin
    SeattleSNPshttp://pga.gs.washington.edu/data/lep/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LEP gene:
    Search GeneIP for patents involving LEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     OriGene qSTAR qPCR primer pairs in human, mouse for LEP   OriGene Purified Protein for LEP  
     OriGene ORF clones in mouse, rat for LEP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LEP   OriGene Custom Protein Services for LEP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LEP
     QIAGEN SeqTarget long-range PCR primers for resequencing LEP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LEP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LEP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LEP
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     GenScript Purified and Recombinant Proteins for LEP GenScript cDNA clones with any tag delivered in your preferred vector for LEP
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     Search for Antibodies & Assays

     Regulatory tfbs in LEP promoter
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     Browse Sino Biological Cell Lysates
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     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for LEP
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     Proteins for LEP
     Antibodies for LEP
     ELISAs for LEP
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     Search LifeMap BioReagents cell lines for LEP
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LEP
     SwitchGear 3'UTR luciferase reporter plasmids for LEP
     SwitchGear Promoter luciferase reporter plasmids for LEP
     ThermoFisher Antibody for LEP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LEP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LEP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LEP
    Customized:
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     LSBio Antibodies in human, mouse, rat for LEP
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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