Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LEP Gene

Aliases for LEP Gene

  • Leptin 2 3 5
  • Leptin (Murine Obesity Homolog) 2 3
  • Leptin (Obesity Homolog, Mouse) 2 3
  • Obesity Factor 3 4
  • Obese Protein 3 4
  • OBS 3 4
  • OB 3 4
  • Obese, Mouse, Homolog Of 3
  • LEPD 3

External Ids for LEP Gene

Previous HGNC Symbols for LEP Gene

  • OBS
  • OB

Previous GeneCards Identifiers for LEP Gene

  • GC07P126358
  • GC07P127421
  • GC07P127435
  • GC07P127475
  • GC07P127668
  • GC07P127881
  • GC07P122242

Summaries for LEP Gene

Entrez Gene Summary for LEP Gene

  • This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]

GeneCards Summary for LEP Gene

LEP (Leptin) is a Protein Coding gene. Diseases associated with LEP include obesity, morbid, due to leptin deficiency and congenital leptin deficiency. Among its related pathways are Adipocytokine signaling pathway and AMPK signaling pathway. GO annotations related to this gene include growth factor activity and peptide hormone receptor binding.

UniProtKB/Swiss-Prot for LEP Gene

  • Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T cells proliferation and reduces autophagy during TCR (T cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689).

Tocris Summary for LEP Gene

  • Leptin was initially thought to have a role in energy homeostasis and obesity. It acts via leptin receptors (Ob-Rs), which are transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. There are six isoforms of Ob-R.

Gene Wiki entry for LEP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEP Gene

Genomics for LEP Gene

Regulatory Elements for LEP Gene

Enhancers for LEP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LEP on UCSC Golden Path with GeneCards custom track

Genomic Location for LEP Gene

Chromosome:
7
Start:
128,241,202 bp from pter
End:
128,257,629 bp from pter
Size:
16,428 bases
Orientation:
Plus strand

Genomic View for LEP Gene

Genes around LEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEP Gene

Proteins for LEP Gene

  • Protein details for LEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41159-LEP_HUMAN
    Recommended name:
    Leptin
    Protein Accession:
    P41159
    Secondary Accessions:
    • O15158
    • Q56A88

    Protein attributes for LEP Gene

    Size:
    167 amino acids
    Molecular mass:
    18641 Da
    Quaternary structure:
    • Interacts with SIGLEC6.

    Three dimensional structures from OCA and Proteopedia for LEP Gene

neXtProt entry for LEP Gene

Proteomics data for LEP Gene at MOPED

Post-translational modifications for LEP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LEP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Assay Products

  • Enzo Life Sciences assays for LEP

No data available for DME Specific Peptides for LEP Gene

Domains & Families for LEP Gene

Protein Domains for LEP Gene

Suggested Antigen Peptide Sequences for LEP Gene

Graphical View of Domain Structure for InterPro Entry

P41159

UniProtKB/Swiss-Prot:

LEP_HUMAN :
  • Belongs to the leptin family.
Family:
  • Belongs to the leptin family.
genes like me logo Genes that share domains with LEP: view

No data available for Gene Families for LEP Gene

Function for LEP Gene

Molecular function for LEP Gene

GENATLAS Biochemistry:
leptin,adipocyte-specific secreted protein,18.6kDa,controlling the size of adipose depot by a profound effect of appen appetite and energy expenditure,also involved in control of the hypothalamic-pituitary-gonadal (HPG) axis,also putative angiogenic factor,homolog of the murine obese gene (ob)
UniProtKB/Swiss-Prot Function:
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T cells proliferation and reduces autophagy during TCR (T cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689).
UniProtKB/Swiss-Prot Induction:
Induced by secretin.
genes like me logo Genes that share phenotypes with LEP: view

Human Phenotype Ontology for LEP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LEP Gene

MGI Knock Outs for LEP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for LEP Gene

Localization for LEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LEP Gene COMPARTMENTS Subcellular localization image for LEP gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
peroxisome 2
plasma membrane 2
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for LEP Gene

Pathways & Interactions for LEP Gene

genes like me logo Genes that share pathways with LEP: view

SIGNOR curated interactions for LEP Gene

Activates:

Gene Ontology (GO) - Biological Process for LEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis IDA 19910644
GO:0001542 ovulation from ovarian follicle IEA --
GO:0001666 response to hypoxia IEA --
GO:0001819 positive regulation of cytokine production IEA --
genes like me logo Genes that share ontologies with LEP: view

Drugs & Compounds for LEP Gene

(91) Drugs for LEP Gene - From: PharmGKB, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olanzapine Approved, Investigational Pharma Antagonist 380
Risperidone Approved, Investigational Pharma Antagonist SR-2A inhibitor 477
Androstenedione Experimental, Illicit Pharma 0
LEP (116-130) (mouse) Pharma An antiobesity hormone, Synthetic leptin peptide fragment 0
antipsychotics Pharma 0

(41) Additional Compounds for LEP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) Tocris Compounds for LEP Gene

Compound Action Cas Number
LEP (116-130) (mouse) Synthetic leptin peptide fragment 258276-95-8

(1) ApexBio Compounds for LEP Gene

Compound Action Cas Number
LEP (116-130) (mouse) An antiobesity hormone 258276-95-8
genes like me logo Genes that share compounds with LEP: view

Transcripts for LEP Gene

mRNA/cDNA for LEP Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LEP Gene

Leptin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LEP Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for LEP Gene

GeneLoc Exon Structure for
LEP
ECgene alternative splicing isoforms for
LEP

Expression for LEP Gene

mRNA expression in normal human tissues for LEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LEP Gene

This gene is overexpressed in Adipose - Subcutaneous (x28.2), Adipose - Visceral (Omentum) (x12.3), and Breast - Mammary Tissue (x7.1).

Protein differential expression in normal tissues from HIPED for LEP Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LEP Gene



SOURCE GeneReport for Unigene cluster for LEP Gene Hs.194236

mRNA Expression by UniProt/SwissProt for LEP Gene

P41159-LEP_HUMAN
Tissue specificity: Adipose tissue is the main source of leptin it is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907).
genes like me logo Genes that share expression patterns with LEP: view

Protein tissue co-expression partners for LEP Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LEP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LEP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LEP 35
  • 86.63 (n)
  • 84.43 (a)
OB 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LEP 35
  • 87.03 (n)
  • 80.24 (a)
LEP 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lep 35
  • 82.63 (n)
  • 83.23 (a)
Lep 16
Lep 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LEP 35
  • 99.2 (n)
  • 99.4 (a)
LEP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lep 35
  • 83.43 (n)
  • 82.04 (a)
oppossum
(Monodelphis domestica)
Mammalia LEP 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LEP 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486715 35
  • 49.9 (n)
  • 36.2 (a)
zebrafish
(Danio rerio)
Actinopterygii lepa 36
  • 22 (a)
OneToOne
Species with no ortholog for LEP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LEP Gene

ENSEMBL:
Gene Tree for LEP (if available)
TreeFam:
Gene Tree for LEP (if available)

Paralogs for LEP Gene

No data available for Paralogs for LEP Gene

Variants for LEP Gene

Sequence variations from dbSNP and Humsavar for LEP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17151919 - 128,254,539(+) GAAAC(A/G)TGATC reference, missense
rs104894023 Leptin deficiency (LEPD) 128,254,572(+) ACCTC(C/T)GGGAT reference, missense
rs1800564 - 128,254,587(+) TTCAC(A/G/T)TGCTG reference, missense
VAR_075144 Leptin deficiency (LEPD)
rs791616 -- 128,239,290(+) tccta(C/T)gcaat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LEP Gene

Variant ID Type Subtype PubMed ID
esv33413 CNV Gain 17666407

Variation tolerance for LEP Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LEP Gene

HapMap Linkage Disequilibrium report
LEP
Human Gene Mutation Database (HGMD)
LEP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEP Gene

Disorders for LEP Gene

MalaCards: The human disease database

(83) MalaCards diseases for LEP Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity, morbid, due to leptin deficiency
  • leptin deficiency
congenital leptin deficiency
  • obesity, morbid, due to leptin deficiency
leptin deficiency
  • obesity, severe, due to leptin deficiency
metabolic syndrome x
  • abdominal obesity-metabolic syndrome
gestational diabetes
  • gdm
- elite association - COSMIC cancer census association via MalaCards
Search LEP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LEP_HUMAN
  • Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age. {ECO:0000269 PubMed:25551525, ECO:0000269 PubMed:9500540}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LEP

Genetic Association Database (GAD)
LEP
Human Genome Epidemiology (HuGE) Navigator
LEP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEP
genes like me logo Genes that share disorders with LEP: view

No data available for Genatlas for LEP Gene

Publications for LEP Gene

  1. Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. (PMID: 8621021) Niki T. … Kasuga M. (Diabetes 1996) 3 4 48 67
  2. Leptin, adiponectin, their ratio and risk of Coronary Heart Disease: results from the MONICA/KORA Augsburg Study 1984-2002. (PMID: 19732895) Karakas M. … Thorand B. (Atherosclerosis 2010) 3 23
  3. Interrelationships of Factor VII activity and plasma leptin with insulin resistance in coronary heart disease. (PMID: 19781705) Karatela R.A. … Sainani G.S. (Atherosclerosis 2010) 3 23
  4. Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study. (PMID: 20019673) Asferg C. … Jeppesen J. (Am. J. Hypertens. 2010) 3 23
  5. Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression. (PMID: 20141628) Mutabaruka M.S. … Lajeunesse D. (Arthritis Res. Ther. 2010) 3 23

Products for LEP Gene

Sources for LEP Gene

Content