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Aliases for LEO1 Gene

Aliases for LEO1 Gene

  • LEO1 Homolog, Paf1/RNA Polymerase II Complex Component 2 3 5
  • Replicative Senescence Down-Regulated Leo1-Like Protein 3 4
  • RDL 3 4
  • Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) 2
  • Leo1, Paf1/RNA Polymerase II Complex Component, Homolog 3
  • Leo1 Paf1/RNA Polymerase II Complex Component 3

External Ids for LEO1 Gene

Previous GeneCards Identifiers for LEO1 Gene

  • GC15M050018
  • GC15M052230
  • GC15M029060
  • GC15M052414
  • GC15M052684

Summaries for LEO1 Gene

Entrez Gene Summary for LEO1 Gene

  • LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LEO1 Gene

LEO1 (LEO1 Homolog, Paf1/RNA Polymerase II Complex Component) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

UniProtKB/Swiss-Prot for LEO1 Gene

  • Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys-4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.

Gene Wiki entry for LEO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEO1 Gene

Genomics for LEO1 Gene

Regulatory Elements for LEO1 Gene

Enhancers for LEO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LEO1 on UCSC Golden Path with GeneCards custom track

Promoters for LEO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LEO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LEO1 Gene

Chromosome:
15
Start:
51,938,025 bp from pter
End:
51,971,806 bp from pter
Size:
33,782 bases
Orientation:
Minus strand

Genomic View for LEO1 Gene

Genes around LEO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEO1 Gene

Proteins for LEO1 Gene

  • Protein details for LEO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVC0-LEO1_HUMAN
    Recommended name:
    RNA polymerase-associated protein LEO1
    Protein Accession:
    Q8WVC0
    Secondary Accessions:
    • Q96N99

    Protein attributes for LEO1 Gene

    Size:
    666 amino acids
    Molecular mass:
    75404 Da
    Quaternary structure:
    • Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Interacts with TCEA1, SUPT5H and CTNNB1.
    SequenceCaution:
    • Sequence=BAB71006.1; Type=Frameshift; Positions=473; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LEO1 Gene

    Alternative splice isoforms for LEO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LEO1 Gene

Proteomics data for LEO1 Gene at MOPED

Post-translational modifications for LEO1 Gene

  • Ubiquitination at Lys 486
  • Modification sites at PhosphoSitePlus

Other Protein References for LEO1 Gene

No data available for DME Specific Peptides for LEO1 Gene

Domains & Families for LEO1 Gene

Gene Families for LEO1 Gene

Protein Domains for LEO1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LEO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVC0

UniProtKB/Swiss-Prot:

LEO1_HUMAN :
  • Belongs to the LEO1 family.
Family:
  • Belongs to the LEO1 family.
genes like me logo Genes that share domains with LEO1: view

Function for LEO1 Gene

Molecular function for LEO1 Gene

UniProtKB/Swiss-Prot Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys-4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.

Gene Ontology (GO) - Molecular Function for LEO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15923622
genes like me logo Genes that share ontologies with LEO1: view
genes like me logo Genes that share phenotypes with LEO1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LEO1 Gene

Localization for LEO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LEO1 Gene COMPARTMENTS Subcellular localization image for LEO1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for LEO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with LEO1: view

Pathways & Interactions for LEO1 Gene

genes like me logo Genes that share pathways with LEO1: view

Gene Ontology (GO) - Biological Process for LEO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001711 endodermal cell fate commitment ISS --
GO:0006378 mRNA polyadenylation IMP 21329879
GO:0010390 histone monoubiquitination IDA 16307923
GO:0016055 Wnt signaling pathway IEA --
GO:0016570 histone modification IEA --
genes like me logo Genes that share ontologies with LEO1: view

No data available for SIGNOR curated interactions for LEO1 Gene

Drugs & Compounds for LEO1 Gene

(6) Drugs for LEO1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for LEO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LEO1: view

Transcripts for LEO1 Gene

Unigene Clusters for LEO1 Gene

Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LEO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - - -
SP3:

Relevant External Links for LEO1 Gene

GeneLoc Exon Structure for
LEO1
ECgene alternative splicing isoforms for
LEO1

Expression for LEO1 Gene

mRNA expression in normal human tissues for LEO1 Gene

Protein differential expression in normal tissues from HIPED for LEO1 Gene

This gene is overexpressed in Breast (29.3) and Lung (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LEO1 Gene



SOURCE GeneReport for Unigene cluster for LEO1 Gene Hs.567662

mRNA Expression by UniProt/SwissProt for LEO1 Gene

Q8WVC0-LEO1_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver.
genes like me logo Genes that share expression patterns with LEO1: view

Protein tissue co-expression partners for LEO1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LEO1 Gene

Orthologs for LEO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LEO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LEO1 35
  • 93.23 (n)
  • 97.25 (a)
LEO1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LEO1 35
  • 94.06 (n)
  • 97.87 (a)
LEO1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Leo1 35
  • 86.93 (n)
  • 93.77 (a)
Leo1 16
Leo1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LEO1 35
  • 100 (n)
  • 100 (a)
LEO1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Leo1 35
  • 86.37 (n)
  • 93.92 (a)
oppossum
(Monodelphis domestica)
Mammalia LEO1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves LEO1 35
  • 78.52 (n)
  • 87.52 (a)
LEO1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LEO1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia leo1 35
  • 74.77 (n)
  • 77.83 (a)
Str.6732 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24216 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11557 35
leo1 35
  • 64.15 (n)
  • 69.5 (a)
leo1 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Atu 36
  • 34 (a)
OneToMany
CG10887 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0035.11 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEO1 36
  • 25 (a)
OneToOne
LEO1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for LEO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LEO1 Gene

ENSEMBL:
Gene Tree for LEO1 (if available)
TreeFam:
Gene Tree for LEO1 (if available)

Paralogs for LEO1 Gene

Pseudogenes.org Pseudogenes for LEO1 Gene

genes like me logo Genes that share paralogs with LEO1: view

No data available for Paralogs for LEO1 Gene

Variants for LEO1 Gene

Sequence variations from dbSNP and Humsavar for LEO1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs7162554 -- 51,954,218(+) gtgcc(C/T)ggctc intron-variant
rs1025184 -- 51,971,068(+) CTCTG(C/T)ACACA intron-variant
rs1025185 -- 51,971,295(+) CCCAC(A/C)CCATC intron-variant
rs1035739 -- 51,962,709(-) agtta(C/T)acagt intron-variant
rs57591722 -- 51,959,402(+) TATGT(A/G)ACTCT intron-variant

Variation tolerance for LEO1 Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for LEO1 Gene

Disorders for LEO1 Gene

Relevant External Links for LEO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEO1

No disorders were found for LEO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEO1 Gene

Publications for LEO1 Gene

  1. The parafibromin tumor suppressor protein is part of a human Paf1 complex. (PMID: 15632063) Rozenblatt-Rosen O. … Meyerson M. (Mol. Cell. Biol. 2005) 2 3 4 67
  2. Structural insights into Paf1 complex assembly and histone binding. (PMID: 24038468) Chu X. … Long J. (Nucleic Acids Res. 2013) 2 3
  3. Expression of the Leo1-like domain of replicative senescence down- regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts. (PMID: 15791002) Zhao L. … Zhang Z. (FASEB J. 2005) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for LEO1 Gene

Sources for LEO1 Gene

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