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Aliases for LENG8 Gene

Aliases for LENG8 Gene

  • Leukocyte Receptor Cluster Member 8 2 3 5
  • Leukocyte Receptor Cluster (LRC) Member 8 2 3
  • KIAA1932 4
  • Pp13842 3

External Ids for LENG8 Gene

Previous GeneCards Identifiers for LENG8 Gene

  • GC19U990238
  • GC19P059636
  • GC19P059652
  • GC19P059651
  • GC19P054960
  • GC19P051284

Summaries for LENG8 Gene

GeneCards Summary for LENG8 Gene

LENG8 (Leukocyte Receptor Cluster Member 8) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LENG8 Gene

Genomics for LENG8 Gene

Regulatory Elements for LENG8 Gene

Enhancers for LENG8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around LENG8 on UCSC Golden Path with GeneCards custom track

Promoters for LENG8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for LENG8 Gene

54,448,719 bp from pter
54,462,046 bp from pter
13,328 bases
Plus strand

Genomic View for LENG8 Gene

Genes around LENG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG8 Gene

Proteins for LENG8 Gene

  • Protein details for LENG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte receptor cluster member 8
    Protein Accession:
    Secondary Accessions:
    • B0VJY9
    • Q8IZ27
    • Q8NCX6

    Protein attributes for LENG8 Gene

    779 amino acids
    Molecular mass:
    86129 Da
    Quaternary structure:
    • May be part of a SHFM1-containing complex.
    • Sequence=BAB67825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LENG8 Gene


neXtProt entry for LENG8 Gene

Post-translational modifications for LENG8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LENG8 Gene

Domains & Families for LENG8 Gene

Protein Domains for LENG8 Gene


Suggested Antigen Peptide Sequences for LENG8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LENG8: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LENG8 Gene

Function for LENG8 Gene

Gene Ontology (GO) - Molecular Function for LENG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with LENG8: view
genes like me logo Genes that share phenotypes with LENG8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG8 Gene

Localization for LENG8 Gene

Subcellular locations from

Jensen Localization Image for LENG8 Gene COMPARTMENTS Subcellular localization image for LENG8 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LENG8 Gene

Pathways & Interactions for LENG8 Gene

SuperPathways for LENG8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LENG8 Gene


No data available for Pathways by source and SIGNOR curated interactions for LENG8 Gene

Drugs & Compounds for LENG8 Gene

No Compound Related Data Available

Transcripts for LENG8 Gene

Unigene Clusters for LENG8 Gene

Leukocyte receptor cluster (LRC) member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LENG8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: -
SP2: -
SP5: -
SP6: - -
SP8: - - -

ExUns: 19b ^ 20

Relevant External Links for LENG8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LENG8 Gene

mRNA expression in normal human tissues for LENG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LENG8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Placenta (8.1), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LENG8 Gene

Protein tissue co-expression partners for LENG8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LENG8 Gene:


SOURCE GeneReport for Unigene cluster for LENG8 Gene:

genes like me logo Genes that share expression patterns with LENG8: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LENG8 Gene

Orthologs for LENG8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LENG8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LENG8 34
  • 88.29 (n)
  • 92.94 (a)
LENG8 35
  • 84 (a)
(Canis familiaris)
Mammalia LENG8 34
  • 90.21 (n)
  • 95 (a)
LENG8 35
  • 95 (a)
(Mus musculus)
Mammalia Leng8 34
  • 86.75 (n)
  • 92.64 (a)
Leng8 16
Leng8 35
  • 90 (a)
(Pan troglodytes)
Mammalia LENG8 34
  • 99.33 (n)
  • 99.62 (a)
LENG8 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Leng8 34
  • 86.21 (n)
  • 92.77 (a)
(Monodelphis domestica)
Mammalia LENG8 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia LENG8 35
  • 74 (a)
(Anolis carolinensis)
Reptilia LENG8 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495696 34
  • 63.32 (n)
  • 65.81 (a)
(Danio rerio)
Actinopterygii zgc:158262 34
  • 55.95 (n)
  • 56.44 (a)
LENG8 35
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6700 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea hpo-10 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THP3 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
-- 35
  • 59 (a)
Species where no ortholog for LENG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LENG8 Gene

Gene Tree for LENG8 (if available)
Gene Tree for LENG8 (if available)

Paralogs for LENG8 Gene

No data available for Paralogs for LENG8 Gene

Variants for LENG8 Gene

Sequence variations from dbSNP and Humsavar for LENG8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035294 -
VAR_035295 -

Structural Variations from Database of Genomic Variants (DGV) for LENG8 Gene

Variant ID Type Subtype PubMed ID
dgv3663n100 CNV gain 25217958
esv2758771 CNV gain+loss 17122850
nsv1148744 OTHER inversion 26484159
nsv833878 CNV loss 17160897
nsv953617 CNV deletion 24416366
nsv9758 CNV gain 18304495

Variation tolerance for LENG8 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LENG8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG8 Gene

Disorders for LENG8 Gene

Relevant External Links for LENG8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LENG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LENG8 Gene

Publications for LENG8 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 3 4 65
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 65
  3. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C. (PMID: 26471122) Cano F. … Lehner P.J. (Nat Commun 2015) 3 65

Products for LENG8 Gene

Sources for LENG8 Gene

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