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Aliases for LENG8 Gene

Aliases for LENG8 Gene

  • Leukocyte Receptor Cluster Member 8 2 3 5
  • Leukocyte Receptor Cluster (LRC) Member 8 2 3
  • KIAA1932 4
  • Pp13842 3

External Ids for LENG8 Gene

Previous GeneCards Identifiers for LENG8 Gene

  • GC19U990238
  • GC19P059636
  • GC19P059652
  • GC19P059651
  • GC19P054960
  • GC19P051284

Summaries for LENG8 Gene

GeneCards Summary for LENG8 Gene

LENG8 (Leukocyte Receptor Cluster Member 8) is a Protein Coding gene.

Additional gene information for LENG8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LENG8 Gene

Genomics for LENG8 Gene

Regulatory Elements for LENG8 Gene

Enhancers for LENG8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H055215 1.5 ENCODE dbSUPER 142.6 +768.0 767986 2 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ENSG00000267523 SSC5D ZNF580 ZNF628 ENSG00000267096 BRSK1
GH19H054199 1.9 FANTOM5 ENCODE dbSUPER 58 -243.0 -243009 12 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D PRPF31 CNOT3 LENG8 LENG8-AS1 ZNF525 LILRB5 ZNF845 ZNF765 ENSG00000235681 RPS9
GH19H055337 1.8 FANTOM5 ENCODE dbSUPER 44 +891.1 891109 4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ZNF628 FAM71E2 SSC5D KMT5C PPP6R1 LOC729999
GH19H055246 1.7 Ensembl ENCODE dbSUPER 41 +805.1 805140 14 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 LENG8 LENG8-AS1 U2AF2 ZNF628 ENSG00000235681 ZNF581 BRSK1 HSPBP1 FIZ1 TMEM86B
GH19H054459 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.9 +17.1 17136 12 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF143 ZNF207 PAF1 SP3 LENG8-AS1 LENG8 CNOT3 PRPF31 ENSG00000267838 ENSG00000235681 LENG9 MYADM TPM3P6 TTYH1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LENG8 on UCSC Golden Path with GeneCards custom track

Promoters for LENG8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111514 481 2801 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for LENG8 Gene

Chromosome:
19
Start:
54,448,719 bp from pter
End:
54,462,046 bp from pter
Size:
13,328 bases
Orientation:
Plus strand

Genomic View for LENG8 Gene

Genes around LENG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG8 Gene

Proteins for LENG8 Gene

  • Protein details for LENG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PV6-LENG8_HUMAN
    Recommended name:
    Leukocyte receptor cluster member 8
    Protein Accession:
    Q96PV6
    Secondary Accessions:
    • B0VJY9
    • Q8IZ27
    • Q8NCX6

    Protein attributes for LENG8 Gene

    Size:
    779 amino acids
    Molecular mass:
    86129 Da
    Quaternary structure:
    • May be part of a SEM1-containing complex.
    SequenceCaution:
    • Sequence=BAB67825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LENG8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LENG8 Gene

Post-translational modifications for LENG8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LENG8 Gene

Domains & Families for LENG8 Gene

Gene Families for LENG8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LENG8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LENG8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LENG8: view

No data available for UniProtKB/Swiss-Prot for LENG8 Gene

Function for LENG8 Gene

Phenotypes From GWAS Catalog for LENG8 Gene

Gene Ontology (GO) - Molecular Function for LENG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with LENG8: view
genes like me logo Genes that share phenotypes with LENG8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LENG8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG8 Gene

Localization for LENG8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LENG8 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LENG8 Gene

Pathways & Interactions for LENG8 Gene

SuperPathways for LENG8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LENG8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LENG8 Gene

Drugs & Compounds for LENG8 Gene

No Compound Related Data Available

Transcripts for LENG8 Gene

Unigene Clusters for LENG8 Gene

Leukocyte receptor cluster (LRC) member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LENG8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LENG8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:

ExUns: 19b ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for LENG8 Gene

GeneLoc Exon Structure for
LENG8
ECgene alternative splicing isoforms for
LENG8

Expression for LENG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LENG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LENG8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Placenta (8.1), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LENG8 Gene



Protein tissue co-expression partners for LENG8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LENG8 Gene:

LENG8

SOURCE GeneReport for Unigene cluster for LENG8 Gene:

Hs.502378

Evidence on tissue expression from TISSUES for LENG8 Gene

  • Nervous system(2.8)
  • Intestine(2.4)
  • Kidney(2.1)
  • Lung(2.1)
  • Eye(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with LENG8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LENG8 Gene

Orthologs for LENG8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LENG8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LENG8 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia LENG8 33 34
  • 90.21 (n)
cow
(Bos Taurus)
Mammalia LENG8 33 34
  • 88.29 (n)
mouse
(Mus musculus)
Mammalia Leng8 33 16 34
  • 86.75 (n)
rat
(Rattus norvegicus)
Mammalia Leng8 33
  • 86.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LENG8 34
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LENG8 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LENG8 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495696 33
  • 63.32 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:158262 33
  • 55.95 (n)
LENG8 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6700 34
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hpo-10 34
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THP3 34
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
Species where no ortholog for LENG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LENG8 Gene

ENSEMBL:
Gene Tree for LENG8 (if available)
TreeFam:
Gene Tree for LENG8 (if available)

Paralogs for LENG8 Gene

No data available for Paralogs for LENG8 Gene

Variants for LENG8 Gene

Sequence variations from dbSNP and Humsavar for LENG8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35061854 --
rs35336528 --
rs909407816 -- 54,448,001(+) ACAAA(-/ACAAAC)CCCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LENG8 Gene

Variant ID Type Subtype PubMed ID
dgv3663n100 CNV gain 25217958
esv2758771 CNV gain+loss 17122850
nsv1148744 OTHER inversion 26484159
nsv833878 CNV loss 17160897
nsv953617 CNV deletion 24416366
nsv9758 CNV gain 18304495

Variation tolerance for LENG8 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LENG8 Gene

Human Gene Mutation Database (HGMD)
LENG8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LENG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG8 Gene

Disorders for LENG8 Gene

Relevant External Links for LENG8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LENG8

No disorders were found for LENG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LENG8 Gene

Publications for LENG8 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 60
  3. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for LENG8 Gene

Sources for LENG8 Gene

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