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Aliases for LENG8 Gene

Aliases for LENG8 Gene

  • Leukocyte Receptor Cluster (LRC) Member 8 2 3
  • KIAA1932 4
  • Pp13842 3

External Ids for LENG8 Gene

Previous GeneCards Identifiers for LENG8 Gene

  • GC19U990238
  • GC19P059636
  • GC19P059652
  • GC19P059651
  • GC19P054960
  • GC19P051284

Summaries for LENG8 Gene

GeneCards Summary for LENG8 Gene

LENG8 (Leukocyte Receptor Cluster (LRC) Member 8) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LENG8 Gene

Genomics for LENG8 Gene

Regulatory Elements for LENG8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LENG8 Gene

Chromosome:
19
Start:
54,448,719 bp from pter
End:
54,462,046 bp from pter
Size:
13,328 bases
Orientation:
Plus strand

Genomic View for LENG8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LENG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG8 Gene

Proteins for LENG8 Gene

  • Protein details for LENG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PV6-LENG8_HUMAN
    Recommended name:
    Leukocyte receptor cluster member 8
    Protein Accession:
    Q96PV6
    Secondary Accessions:
    • B0VJY9
    • Q8IZ27
    • Q8NCX6

    Protein attributes for LENG8 Gene

    Size:
    779 amino acids
    Molecular mass:
    86129 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB67825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LENG8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LENG8 Gene

Proteomics data for LENG8 Gene at MOPED

Post-translational modifications for LENG8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LENG8 Gene

Domains & Families for LENG8 Gene

Protein Domains for LENG8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LENG8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LENG8: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LENG8 Gene

Function for LENG8 Gene

Gene Ontology (GO) - Molecular Function for LENG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with LENG8: view

Phenotypes for LENG8 Gene

GenomeRNAi human phenotypes for LENG8:
genes like me logo Genes that share phenotypes with LENG8: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LENG8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG8 Gene

Localization for LENG8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LENG8 Gene

Pathways & Interactions for LENG8 Gene

SuperPathways for LENG8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LENG8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LENG8 Gene

Drugs & Compounds for LENG8 Gene

No Compound Related Data Available

Transcripts for LENG8 Gene

Unigene Clusters for LENG8 Gene

Leukocyte receptor cluster (LRC) member 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LENG8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LENG8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:

ExUns: 19b ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for LENG8 Gene

GeneLoc Exon Structure for
LENG8
ECgene alternative splicing isoforms for
LENG8

Expression for LENG8 Gene

mRNA expression in normal human tissues for LENG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LENG8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Placenta (8.1), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LENG8 Gene



SOURCE GeneReport for Unigene cluster for LENG8 Gene Hs.502378

genes like me logo Genes that share expression patterns with LENG8: view

Protein tissue co-expression partners for LENG8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LENG8 Gene

Orthologs for LENG8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LENG8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LENG8 35
  • 88.29 (n)
  • 92.94 (a)
LENG8 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LENG8 35
  • 90.21 (n)
  • 95 (a)
LENG8 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Leng8 35
  • 86.75 (n)
  • 92.64 (a)
Leng8 16
Leng8 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LENG8 35
  • 99.33 (n)
  • 99.62 (a)
LENG8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Leng8 35
  • 86.21 (n)
  • 92.77 (a)
oppossum
(Monodelphis domestica)
Mammalia LENG8 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LENG8 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LENG8 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495696 35
  • 63.32 (n)
  • 65.81 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:158262 35
  • 55.95 (n)
  • 56.44 (a)
LENG8 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6700 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hpo-10 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THP3 36
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
Species with no ortholog for LENG8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LENG8 Gene

ENSEMBL:
Gene Tree for LENG8 (if available)
TreeFam:
Gene Tree for LENG8 (if available)

Paralogs for LENG8 Gene

No data available for Paralogs for LENG8 Gene

Variants for LENG8 Gene

Sequence variations from dbSNP and Humsavar for LENG8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_035295 -
VAR_035294 -
rs778432647 -- 1(+) TGTGC(C/T)TCTCT intron-variant
rs574029521 -- 1(+) TGTGC(-/CT)CTCTG intron-variant
rs267605667 untested 54,455,996(+) GAGCC(C/T)TAAGA reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for LENG8 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
nsv833878 CNV Loss 17160897
nsv9758 CNV Gain 18304495
nsv912413 CNV Loss 21882294

Variation tolerance for LENG8 Gene

Residual Variation Intolerance Score: 23.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LENG8 Gene

HapMap Linkage Disequilibrium report
LENG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG8 Gene

Disorders for LENG8 Gene

Relevant External Links for LENG8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LENG8
genes like me logo Genes that share disorders with LENG8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LENG8 Gene

Publications for LENG8 Gene

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 67

Products for LENG8 Gene

Sources for LENG8 Gene

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