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Aliases for LENG1 Gene

Aliases for LENG1 Gene

  • Leukocyte Receptor Cluster (LRC) Member 1 2 3 5

External Ids for LENG1 Gene

Previous GeneCards Identifiers for LENG1 Gene

  • GC19M055305
  • GC19M055084
  • GC19M059335
  • GC19M059351
  • GC19M054658
  • GC19M050976

Summaries for LENG1 Gene

GeneCards Summary for LENG1 Gene

LENG1 (Leukocyte Receptor Cluster (LRC) Member 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LENG1 Gene

Genomics for LENG1 Gene

Regulatory Elements for LENG1 Gene

Promoters for LENG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LENG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LENG1 Gene

Chromosome:
19
Start:
54,155,161 bp from pter
End:
54,159,882 bp from pter
Size:
4,722 bases
Orientation:
Minus strand

Genomic View for LENG1 Gene

Genes around LENG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG1 Gene

Proteins for LENG1 Gene

  • Protein details for LENG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BZ8-LENG1_HUMAN
    Recommended name:
    Leukocyte receptor cluster member 1
    Protein Accession:
    Q96BZ8
    Secondary Accessions:
    • Q9HCU7

    Protein attributes for LENG1 Gene

    Size:
    264 amino acids
    Molecular mass:
    30529 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.
    SequenceCaution:
    • Sequence=AAG01393.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LENG1 Gene

Proteomics data for LENG1 Gene at MOPED

Post-translational modifications for LENG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LENG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LENG1 Gene

Domains & Families for LENG1 Gene

Protein Domains for LENG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LENG1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LENG1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LENG1 Gene

Function for LENG1 Gene

genes like me logo Genes that share phenotypes with LENG1: view

Animal Model Products

miRNA for LENG1 Gene

miRTarBase miRNAs that target LENG1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG1 Gene

Localization for LENG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LENG1 Gene COMPARTMENTS Subcellular localization image for LENG1 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LENG1 Gene

Pathways & Interactions for LENG1 Gene

SuperPathways for LENG1 Gene

No Data Available

Interacting Proteins for LENG1 Gene

Gene Ontology (GO) - Biological Process for LENG1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LENG1 Gene

Drugs & Compounds for LENG1 Gene

No Compound Related Data Available

Transcripts for LENG1 Gene

mRNA/cDNA for LENG1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LENG1 Gene

Leukocyte receptor cluster (LRC) member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LENG1 Gene

No ASD Table

Relevant External Links for LENG1 Gene

GeneLoc Exon Structure for
LENG1
ECgene alternative splicing isoforms for
LENG1

Expression for LENG1 Gene

mRNA expression in normal human tissues for LENG1 Gene

Protein differential expression in normal tissues from HIPED for LENG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8), Testis (12.3), CD8 Tcells (11.5), and Blymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for LENG1 Gene



SOURCE GeneReport for Unigene cluster for LENG1 Gene Hs.590974

genes like me logo Genes that share expression patterns with LENG1: view

Protein tissue co-expression partners for LENG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LENG1 Gene

Orthologs for LENG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LENG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LENG1 35
  • 85.82 (n)
  • 86.21 (a)
LENG1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LENG1 35
  • 84.48 (n)
  • 82.06 (a)
LENG1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Leng1 35
  • 81.41 (n)
  • 81.92 (a)
Leng1 16
Leng1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LENG1 35
  • 98.86 (n)
  • 97.35 (a)
LENG1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Leng1 35
  • 82.18 (n)
  • 84.23 (a)
oppossum
(Monodelphis domestica)
Mammalia LENG1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LENG1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia leng1 35
  • 61.61 (n)
  • 65.16 (a)
Str.18286 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22904 35
zebrafish
(Danio rerio)
Actinopterygii leng1 35
  • 54.78 (n)
  • 50.41 (a)
leng1 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12818 35
  • 48.27 (n)
  • 43.57 (a)
CG12818 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for LENG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LENG1 Gene

ENSEMBL:
Gene Tree for LENG1 (if available)
TreeFam:
Gene Tree for LENG1 (if available)

Paralogs for LENG1 Gene

Pseudogenes.org Pseudogenes for LENG1 Gene

genes like me logo Genes that share paralogs with LENG1: view

No data available for Paralogs for LENG1 Gene

Variants for LENG1 Gene

Sequence variations from dbSNP and Humsavar for LENG1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_051090 -

Structural Variations from Database of Genomic Variants (DGV) for LENG1 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv4001n71 CNV Loss 21882294
nsv515623 CNV Loss 19592680
dgv4002n71 CNV Loss 21882294
nsv912398 CNV Loss 21882294
nsv510774 CNV Loss 20534489
nsv9751 CNV Gain 18304495

Variation tolerance for LENG1 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LENG1 Gene

HapMap Linkage Disequilibrium report
LENG1
Human Gene Mutation Database (HGMD)
LENG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG1 Gene

Disorders for LENG1 Gene

Relevant External Links for LENG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LENG1

No disorders were found for LENG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LENG1 Gene

Publications for LENG1 Gene

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for LENG1 Gene

Sources for LENG1 Gene

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