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Aliases for LENG1 Gene

Aliases for LENG1 Gene

  • Leukocyte Receptor Cluster Member 1 2 3 5
  • Leukocyte Receptor Cluster (LRC) Member 1 2

External Ids for LENG1 Gene

Previous GeneCards Identifiers for LENG1 Gene

  • GC19M055305
  • GC19M055084
  • GC19M059335
  • GC19M059351
  • GC19M054658
  • GC19M050976

Summaries for LENG1 Gene

GeneCards Summary for LENG1 Gene

LENG1 (Leukocyte Receptor Cluster Member 1) is a Protein Coding gene.

Additional gene information for LENG1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LENG1 Gene

Genomics for LENG1 Gene

GeneHancer (GH) Regulatory Elements for LENG1 Gene

Promoters and enhancers for LENG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I054158 Promoter/Enhancer 1.6 Ensembl ENCODE 576.2 +0.1 126 3.1 HDGF PKNOX1 FOXA2 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 LENG1 CNOT3 TMC4 PRPF31 LENG8-AS1 ZNF765 LENG8 ENSG00000235681 ENSG00000269001 ZNF845
GH19I054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.1 -45.8 -45828 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 LENG8-AS1 CNOT3 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
GH19I054447 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.2 -289.7 -289730 4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LENG8-AS1 GC19M054437 LENG8 LENG1 ENSG00000267838 PRPF31 LENG9 CNOT3 PPP1R12C GC19P054461
GH19I054136 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.9 +21.7 21706 4.2 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 YY1 POLR2B ZNF207 CNOT3 GC19P054140 GC19P054141 TMC4 ZNF765 LENG1 LENG8-AS1 PRPF31 ZNF525 ZNF845
GH19I053864 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +291.0 290968 9.8 HDGF FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B SLC30A9 MYADM LOC105372457 ENSG00000269001 ZNF845 ZNF765 ZNF816 LENG8 ENSG00000235681 ZNF813 TPM3P6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LENG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LENG1 gene promoter:

Genomic Locations for LENG1 Gene

Genomic Locations for LENG1 Gene
chr19:54,155,161-54,159,882
(GRCh38/hg38)
Size:
4,722 bases
Orientation:
Minus strand
chr19:54,658,899-54,663,620
(GRCh37/hg19)

Genomic View for LENG1 Gene

Genes around LENG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LENG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LENG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LENG1 Gene

Proteins for LENG1 Gene

  • Protein details for LENG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BZ8-LENG1_HUMAN
    Recommended name:
    Leukocyte receptor cluster member 1
    Protein Accession:
    Q96BZ8
    Secondary Accessions:
    • Q9HCU7

    Protein attributes for LENG1 Gene

    Size:
    264 amino acids
    Molecular mass:
    30529 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.
    SequenceCaution:
    • Sequence=AAG01393.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LENG1 Gene

Post-translational modifications for LENG1 Gene

No Post-translational modifications

Other Protein References for LENG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LENG1 Gene

Domains & Families for LENG1 Gene

Gene Families for LENG1 Gene

Protein Domains for LENG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LENG1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LENG1: view

No data available for UniProtKB/Swiss-Prot for LENG1 Gene

Function for LENG1 Gene

Phenotypes From GWAS Catalog for LENG1 Gene

Gene Ontology (GO) - Molecular Function for LENG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LENG1: view
genes like me logo Genes that share phenotypes with LENG1: view

Animal Model Products

miRNA for LENG1 Gene

miRTarBase miRNAs that target LENG1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LENG1 Gene

Localization for LENG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LENG1 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LENG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with LENG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LENG1 Gene

Pathways & Interactions for LENG1 Gene

SuperPathways for LENG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LENG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LENG1: view

No data available for Pathways by source and SIGNOR curated interactions for LENG1 Gene

Drugs & Compounds for LENG1 Gene

No Compound Related Data Available

Transcripts for LENG1 Gene

mRNA/cDNA for LENG1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LENG1 Gene

Leukocyte receptor cluster (LRC) member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LENG1 Gene

No ASD Table

Relevant External Links for LENG1 Gene

GeneLoc Exon Structure for
LENG1
ECgene alternative splicing isoforms for
LENG1

Expression for LENG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LENG1 Gene

Protein differential expression in normal tissues from HIPED for LENG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8), Testis (12.3), CD8 Tcells (11.5), and Blymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LENG1 Gene



Protein tissue co-expression partners for LENG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LENG1 Gene:

LENG1

SOURCE GeneReport for Unigene cluster for LENG1 Gene:

Hs.590974
genes like me logo Genes that share expression patterns with LENG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LENG1 Gene

Orthologs for LENG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LENG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LENG1 33 34
  • 98.86 (n)
cow
(Bos Taurus)
Mammalia LENG1 33 34
  • 85.82 (n)
dog
(Canis familiaris)
Mammalia LENG1 33 34
  • 84.48 (n)
rat
(Rattus norvegicus)
Mammalia Leng1 33
  • 82.18 (n)
mouse
(Mus musculus)
Mammalia Leng1 33 16 34
  • 81.41 (n)
oppossum
(Monodelphis domestica)
Mammalia LENG1 34
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LENG1 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia leng1 33
  • 61.61 (n)
Str.18286 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.22904 33
zebrafish
(Danio rerio)
Actinopterygii leng1 33 34
  • 54.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12818 33 34
  • 48.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToOne
Species where no ortholog for LENG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LENG1 Gene

ENSEMBL:
Gene Tree for LENG1 (if available)
TreeFam:
Gene Tree for LENG1 (if available)

Paralogs for LENG1 Gene

No data available for Paralogs for LENG1 Gene

Variants for LENG1 Gene

Sequence variations from dbSNP and Humsavar for LENG1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000142983 -- 54,161,482(-) G/A upstream_transcript_variant
rs1000201134 -- 54,155,547(-) G/A downstream_transcript_variant
rs1000332243 -- 54,157,869(-) C/G intron_variant
rs1000427269 -- 54,157,736(-) A/T intron_variant
rs1001246921 -- 54,161,542(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LENG1 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv3644783 CNV gain 21293372
nsv510774 CNV deletion 20534489
nsv515623 CNV loss 19592680
nsv953613 CNV deletion 24416366
nsv9751 CNV gain 18304495

Variation tolerance for LENG1 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LENG1 Gene

Human Gene Mutation Database (HGMD)
LENG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LENG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LENG1 Gene

Disorders for LENG1 Gene

Additional Disease Information for LENG1

No disorders were found for LENG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LENG1 Gene

Publications for LENG1 Gene

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for LENG1 Gene

Sources for LENG1 Gene

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