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LENG1 Gene

protein-coding   GIFtS: 46
GCID: GC19M054658

Leukocyte Receptor Cluster (LRC) Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukocyte Receptor Cluster (LRC) Member 11 2
Leukocyte Receptor Cluster Member 12

External Ids:    HGNC: 155021   Entrez Gene: 791652   Ensembl: ENSG000001056177   UniProtKB: Q96BZ83   

Export aliases for LENG1 gene to outside databases

Previous GC identifers: GC19M055305 GC19M055084 GC19M059335 GC19M059351 GC19M050976


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LENG1 Gene:
LENG1 (leukocyte receptor cluster (LRC) member 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the LENG1 gene promoter:
         Egr-3   RFX1   Pax-5   Tal-1   FOXF2   E47   c-Ets-1   Evi-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLENG1 promoter sequence
   Search Chromatin IP Primers for LENG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LENG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LENG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LENG1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054658:  view genomic region     (about GC identifiers)

Start:
54,658,899 bp from pter      End:
54,663,620 bp from pter
Size:
4,722 bases      Orientation:
minus strand

Selected alternative locations (see all 8):
Chr19-,NW_003571060 130,490-134,559      Chr19-,NW_003571061 130,490-134,559      Chr19-,NW_003571054 130,489-134,558     
Chr19-,NW_003571059 130,490-134,559      Chr19-,NW_003571058 130,490-134,559      Chr19-,NW_003571057 130,490-134,559     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LENG1_HUMAN, Q96BZ8 (See protein sequence)
Recommended Name: Leukocyte receptor cluster member 1  
Size: 264 amino acids; 30529 Da
Miscellaneous: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4
Sequence caution: Sequence=AAG01393.1; Type=Erroneous initiation;
Secondary accessions: Q9HCU7

Explore the universe of human proteins at neXtProt for LENG1: NX_Q96BZ8

Explore proteomics data for LENG1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LENG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077292.1  
    ENSEMBL proteins: 
     ENSP00000222224  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019339 CIR_N_dom

    Graphical View of Domain Structure for InterPro Entry Q96BZ8

    ProtoNet protein and cluster: Q96BZ8


    Find genes that share domains with LENG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with LENG1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for LENG1:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
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    hsa-mir-27a-3p (MIRT050024)

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    hsa-miR-3121-3p hsa-miR-3148
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with LENG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LENG1
    Interactions:

        Search GeneGlobe Interaction Network for LENG1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for LENG1 (Q96BZ82, 3 ENSP000002222244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLF10Q131182, 3, ENSP000002854074MINT-8259194 I2D: score=2 STRING: ENSP00000285407
    NAGKQ9UJ702, 3MINT-8263478 I2D: score=2 
    OSGEPQ9NPF42, 3MINT-8265157 I2D: score=2 
    PNMA1Q8ND902, 3, ENSP000003189144MINT-65001 I2D: score=4 STRING: ENSP00000318914
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with LENG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LENG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LENG1 gene: 
    NM_024316.1  

    Unigene Cluster for LENG1:

    Leukocyte receptor cluster (LRC) member 1
    Hs.590974  [show with all ESTs]
    Unigene Representative Sequence: BG249859
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000222224(uc002qdm.3)
    miRNA
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    hsa-miR-3121-3p hsa-miR-3148
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat LENG1

    Additional mRNA sequence: 

    AF211966.1 BC014986.1 

    1 DOTS entry:

    DT.95094517 

    22 AceView cDNA sequences:

    NM_024316 AI149762 BU631491 BC014986 BM461901 BE252076 AI701895 AI565534 
    CB160832 AI872501 BU739923 BP870984 BX280294 CF126449 BQ923192 AF211966 
    BU740408 BU623152 BG770161 AI658544 AA779607 AW939253 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LENG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATCTTGC
    LENG1 Expression
    About this image

    LENG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LENG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.590974
        Custom PCR Arrays for LENG1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LENG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LENG1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Leng11 , 5 leukocyte receptor cluster (LRC) member 11, 5 81.41(n)1
    81.92(a)1
      7 (2.11 cM)5
    697571  NM_027203.31  NP_081479.11 
     36600985 
    lizard
    (Anolis carolinensis)
    Reptilia LENG16
    leukocyte receptor cluster (LRC) member 1
    60(a)
    1 ↔ 1
    GL343279.1(1588365-1592107)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.229042 Xenopus laevis transcribed sequence with weak similarity more 76.93(n)    BJ074309.1 
    zebrafish
    (Danio rerio)
    Actinopterygii leng11 leukocyte receptor cluster (LRC) member 1 54.78(n)
    50.41(a)
      447852  NM_001004591.1  NP_001004591.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG128181 CG12818 48.27(n)
    43.57(a)
      41261  NM_141739.2  NP_649996.1 


    ENSEMBL Gene Tree for LENG1 (if available)
    TreeFam Gene Tree for LENG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LENG1 gene

    Find genes that share paralogs with LENG1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LENG1
    PGOHUM00000250587


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LENG1 (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1457854151,2
    --54659967(+) CTAGAA/GGAAAG 1 -- int10--------
    rs1879445381,2
    --54660045(+) ACTCTC/GTAACC 1 -- int10--------
    rs350344121,2
    C,F,H--54660171(+) CTAAGA/GAAGTT 1 -- int17Minor allele frequency- G:0.04NS NA 1086
    rs1460221271,2
    C--54660176(+) AAAGTC/TTGGAC 1 -- int10--------
    rs1156217401,2
    F--54660196(+) TGCCAT/CTGGCC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs736130291,2
    C,F--54660234(+) ACAGCC/TTCTGG 1 -- int13Minor allele frequency- T:0.08WA 122
    rs1387992731,2
    --54660377(+) CTTCTC/TCACCT 1 -- int10--------
    rs352797711,2
    C,H--54660420(+) GACCAG/TAGACG 1 -- int13Minor allele frequency- T:0.01NS NA 184
    rs1414560971,2
    C--54660483(+) CTGCCA/GAGGTG 1 -- int10--------
    rs1422619361,2
    C,F--54660506(+) TCCTTG/CGGTCG 2 /P syn12Minor allele frequency- C:0.00NA EU 5875

    HapMap Linkage Disequilibrium report for LENG1 (54658899 - 54663620 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LENG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718812CNV Deletion23290073
    nsv912398CNV Loss21882294
    nsv515623CNV Loss19592680
    nsv510774CNV Loss20534489
    dgv4002n71CNV Loss21882294
    dgv4001n71CNV Loss21882294
    nsv9751CNV Gain18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LENG1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with LENG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)1, 2, 3 Wende H.... Ziegler A. (Immunogenetics 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (Science 2007)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79165 HGNC: 15502 AceView: LENG1 Ensembl:ENSG00000105617 euGenes: HUgn79165
    ECgene: LENG1 H-InvDB: LENG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LENG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LENG1 gene:
    Search GeneIP for patents involving LENG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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