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Aliases for LEMD1 Gene

Aliases for LEMD1 Gene

  • LEM Domain Containing 1 2 3 5
  • Cancer/Testis Antigen 50 2 3 4
  • LEM Domain Protein 1 3 4
  • LEMP-1 3 4
  • CT50 3 4

External Ids for LEMD1 Gene

Previous GeneCards Identifiers for LEMD1 Gene

  • GC00U991227
  • GC01M202528
  • GC01M202082
  • GC01M203617
  • GC01M205350
  • GC01M176516

Summaries for LEMD1 Gene

GeneCards Summary for LEMD1 Gene

LEMD1 (LEM Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEMD1 Gene

Genomics for LEMD1 Gene

Regulatory Elements for LEMD1 Gene

Enhancers for LEMD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LEMD1 on UCSC Golden Path with GeneCards custom track

Promoters for LEMD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LEMD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LEMD1 Gene

Chromosome:
1
Start:
205,381,378 bp from pter
End:
205,457,091 bp from pter
Size:
75,714 bases
Orientation:
Minus strand

Genomic View for LEMD1 Gene

Genes around LEMD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEMD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEMD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEMD1 Gene

Proteins for LEMD1 Gene

  • Protein details for LEMD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68G75-LEMD1_HUMAN
    Recommended name:
    LEM domain-containing protein 1
    Protein Accession:
    Q68G75
    Secondary Accessions:
    • Q6L9T9
    • Q6L9U0
    • Q6L9U1
    • Q6L9U2
    • Q6L9U3
    • Q6L9U4

    Protein attributes for LEMD1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20326 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LEMD1 Gene

neXtProt entry for LEMD1 Gene

Proteomics data for LEMD1 Gene at MOPED

Post-translational modifications for LEMD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LEMD1 Gene

Domains & Families for LEMD1 Gene

Gene Families for LEMD1 Gene

Protein Domains for LEMD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LEMD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68G75

UniProtKB/Swiss-Prot:

LEMD1_HUMAN :
  • Contains 1 LEM domain.
Domain:
  • Contains 1 LEM domain.
genes like me logo Genes that share domains with LEMD1: view

Function for LEMD1 Gene

Phenotypes for LEMD1 Gene

GenomeRNAi human phenotypes for LEMD1:
genes like me logo Genes that share phenotypes with LEMD1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LEMD1 Gene

Localization for LEMD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEMD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LEMD1 Gene COMPARTMENTS Subcellular localization image for LEMD1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for LEMD1 Gene

Pathways & Interactions for LEMD1 Gene

SuperPathways for LEMD1 Gene

No Data Available

Interacting Proteins for LEMD1 Gene

Gene Ontology (GO) - Biological Process for LEMD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LEMD1 Gene

Drugs & Compounds for LEMD1 Gene

No Compound Related Data Available

Transcripts for LEMD1 Gene

Unigene Clusters for LEMD1 Gene

LEM domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LEMD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3: -
SP4: - -
SP5: - - -

Relevant External Links for LEMD1 Gene

GeneLoc Exon Structure for
LEMD1
ECgene alternative splicing isoforms for
LEMD1

Expression for LEMD1 Gene

mRNA expression in normal human tissues for LEMD1 Gene

mRNA differential expression in normal tissues according to GTEx for LEMD1 Gene

This gene is overexpressed in Testis (x41.9).

Protein differential expression in normal tissues from HIPED for LEMD1 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LEMD1 Gene



SOURCE GeneReport for Unigene cluster for LEMD1 Gene Hs.655520

mRNA Expression by UniProt/SwissProt for LEMD1 Gene

Q68G75-LEMD1_HUMAN
Tissue specificity: Testis-specific. Isoform 6 is detected in 17 of 18 colon cancer tissues examined.
genes like me logo Genes that share expression patterns with LEMD1: view

Protein tissue co-expression partners for LEMD1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LEMD1 Gene

Orthologs for LEMD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LEMD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LEMD1 35
  • 75.14 (n)
  • 59.67 (a)
LEMD1 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LEMD1 35
  • 79.56 (n)
  • 66.3 (a)
LEMD1 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LEMD1 35
  • 98.9 (n)
  • 98.9 (a)
LEMD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102556277 35
  • 69.65 (n)
  • 56.98 (a)
oppossum
(Monodelphis domestica)
Mammalia LEMD1 36
  • 34 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lemd1 36
  • 43 (a)
OneToOne
Species with no ortholog for LEMD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LEMD1 Gene

ENSEMBL:
Gene Tree for LEMD1 (if available)
TreeFam:
Gene Tree for LEMD1 (if available)

Paralogs for LEMD1 Gene

No data available for Paralogs for LEMD1 Gene

Variants for LEMD1 Gene

Sequence variations from dbSNP and Humsavar for LEMD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7531012 - 205,420,464(+) TATTG(A/G)GCCAG nc-transcript-variant, reference, missense
rs984034 -- 205,422,879(-) CTTAC(C/T)TGATG intron-variant, upstream-variant-2KB
rs913727 -- 205,419,559(-) TGAAT(A/C)TGGGA intron-variant
rs913728 -- 205,418,895(-) TCAAC(C/T)TCTGC intron-variant
rs1338623 -- 205,420,750(-) TTGGA(C/G)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LEMD1 Gene

Variant ID Type Subtype PubMed ID
nsv832381 CNV Gain 17160897
nsv873113 CNV Loss 21882294
nsv873114 CNV Gain 21882294

Variation tolerance for LEMD1 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LEMD1 Gene

Disorders for LEMD1 Gene

Relevant External Links for LEMD1

Genetic Association Database (GAD)
LEMD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEMD1

No disorders were found for LEMD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEMD1 Gene

Publications for LEMD1 Gene

  1. Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers. (PMID: 15254688) Yuki D. … Furukawa Y. (Oncol. Rep. 2004) 2 3 4 23 67
  2. Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer. (PMID: 20682177) Ghafouri-Fard S. … Modarressi M.H. (Arch. Med. Res. 2010) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LEMD1 Gene

Sources for LEMD1 Gene

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