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Aliases for LELP1 Gene

Aliases for LELP1 Gene

  • Late Cornified Envelope Like Proline Rich 1 2 3 5
  • Novel Small Proline-Rich Protein 4

External Ids for LELP1 Gene

Previous GeneCards Identifiers for LELP1 Gene

  • GC01P149989
  • GC01P151442
  • GC01P124538

Summaries for LELP1 Gene

GeneCards Summary for LELP1 Gene

LELP1 (Late Cornified Envelope Like Proline Rich 1) is a Protein Coding gene. Among its related pathways are Developmental Biology.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LELP1 Gene

Genomics for LELP1 Gene

Regulatory Elements for LELP1 Gene

Enhancers for LELP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F153231 0.8 Ensembl ENCODE 10.5 +29.4 29360 3.2 HLF CEBPB MNT FOS PRR9 LOR LELP1 SPRR2G RPLP0P4 GC01P153244
GH01F153122 0.8 Ensembl ENCODE 9.5 -79.8 -79831 2.5 TBP KLF17 YBX1 FEZF1 ZBTB40 RAD21 GLIS2 SCRT2 FOS ZNF263 SPRR2C SPRR2G LELP1 SPRR2B SPRR2F
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LELP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LELP1 Gene

Chromosome:
1
Start:
153,203,430 bp from pter
End:
153,205,125 bp from pter
Size:
1,696 bases
Orientation:
Plus strand

Genomic View for LELP1 Gene

Genes around LELP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LELP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LELP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LELP1 Gene

Proteins for LELP1 Gene

  • Protein details for LELP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T871-LELP1_HUMAN
    Recommended name:
    Late cornified envelope-like proline-rich protein 1
    Protein Accession:
    Q5T871
    Secondary Accessions:
    • A1L4E1

    Protein attributes for LELP1 Gene

    Size:
    98 amino acids
    Molecular mass:
    10697 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LELP1 Gene

Post-translational modifications for LELP1 Gene

No Post-translational modifications

Other Protein References for LELP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LELP1 Gene

Domains & Families for LELP1 Gene

Protein Domains for LELP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LELP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T871

UniProtKB/Swiss-Prot:

LELP1_HUMAN :
  • Belongs to the cornifin (SPRR) family.
Family:
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with LELP1: view

No data available for Gene Families for LELP1 Gene

Function for LELP1 Gene

Gene Ontology (GO) - Molecular Function for LELP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
genes like me logo Genes that share ontologies with LELP1: view

Phenotypes for LELP1 Gene

GenomeRNAi human phenotypes for LELP1:
genes like me logo Genes that share phenotypes with LELP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LELP1 Gene

Localization for LELP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LELP1 Gene COMPARTMENTS Subcellular localization image for LELP1 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LELP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with LELP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LELP1 Gene

Pathways & Interactions for LELP1 Gene

SuperPathways for LELP1 Gene

SuperPathway Contained pathways
1 Developmental Biology
genes like me logo Genes that share pathways with LELP1: view

Pathways by source for LELP1 Gene

1 Reactome pathway for LELP1 Gene

Interacting Proteins for LELP1 Gene

Gene Ontology (GO) - Biological Process for LELP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018149 peptide cross-linking IBA --
GO:0030216 keratinocyte differentiation IBA --
genes like me logo Genes that share ontologies with LELP1: view

No data available for SIGNOR curated interactions for LELP1 Gene

Drugs & Compounds for LELP1 Gene

(5) Drugs for LELP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LELP1: view

Transcripts for LELP1 Gene

mRNA/cDNA for LELP1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LELP1 Gene

Late cornified envelope-like proline-rich 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LELP1 Gene

No ASD Table

Relevant External Links for LELP1 Gene

GeneLoc Exon Structure for
LELP1
ECgene alternative splicing isoforms for
LELP1

Expression for LELP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LELP1 Gene

mRNA differential expression in normal tissues according to GTEx for LELP1 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for LELP1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LELP1 Gene



Protein tissue co-expression partners for LELP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LELP1 Gene:

LELP1

SOURCE GeneReport for Unigene cluster for LELP1 Gene:

Hs.125785
genes like me logo Genes that share expression patterns with LELP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LELP1 Gene

Orthologs for LELP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LELP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LELP1 34 35
  • 98.04 (n)
cow
(Bos Taurus)
Mammalia LELP1 35
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lelp1 35
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LELP1 35
  • 48 (a)
OneToOne
Species where no ortholog for LELP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LELP1 Gene

ENSEMBL:
Gene Tree for LELP1 (if available)
TreeFam:
Gene Tree for LELP1 (if available)

Paralogs for LELP1 Gene

No data available for Paralogs for LELP1 Gene

Variants for LELP1 Gene

Sequence variations from dbSNP and Humsavar for LELP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs112525908 -- 153,203,057(+) ATGGC(A/T)GTGAT upstream-variant-2KB
rs113767985 -- 153,204,118(+) AAATT(A/G)CTTTC intron-variant
rs114535146 -- 153,204,412(+) GTGGG(G/T)TGGGG intron-variant
rs11576296 -- 153,203,890(+) TCCGT(A/G)CAGAA intron-variant
rs115840162 -- 153,202,861(+) CCATC(A/G)CCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LELP1 Gene

Variant ID Type Subtype PubMed ID
nsv1004168 CNV loss 25217958
nsv2932 CNV insertion 18451855
nsv547899 CNV gain 21841781

Variation tolerance for LELP1 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LELP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LELP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LELP1 Gene

Disorders for LELP1 Gene

Relevant External Links for LELP1

Genetic Association Database (GAD)
LELP1
Human Genome Epidemiology (HuGE) Navigator
LELP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LELP1

No disorders were found for LELP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LELP1 Gene

Publications for LELP1 Gene

  1. Association of a chromosome 1q21 locus in close proximity to a late cornified envelope-like proline-rich 1 (LELP1) gene with total serum IgE levels. (PMID: 17387579) Sharma M. … Ghosh B. (J. Hum. Genet. 2007) 3 22 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3 64
  5. Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. (PMID: 20230798) Choi H. … Noh M. (Biochem. Pharmacol. 2010) 22 64

Products for LELP1 Gene

Sources for LELP1 Gene

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