Aliases for LEFTY1 Gene
External Ids for LEFTY1 Gene
Previous HGNC Symbols for LEFTY1 Gene
Previous GeneCards Identifiers for LEFTY1 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016]
GeneCards Summary for LEFTY1 Gene
LEFTY1 (Left-Right Determination Factor 1) is a Protein Coding gene. Diseases associated with LEFTY1 include Visceral Heterotaxy. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is LEFTY2.
UniProtKB/Swiss-Prot for LEFTY1 Gene
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.