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Aliases for LEFTY1 Gene

Aliases for LEFTY1 Gene

  • Left-Right Determination Factor 1 2 3 5
  • Left-Right Determination, Factor B 2 3
  • Left-Right Determination Factor B 3 4
  • Protein Lefty-1 3 4
  • Protein Lefty-B 3 4
  • LEFTYB 3 4
  • LEFTB 3 4

External Ids for LEFTY1 Gene

Previous HGNC Symbols for LEFTY1 Gene

  • LEFTB

Previous GeneCards Identifiers for LEFTY1 Gene

  • GC01M222381
  • GC01M224140
  • GC01M226073
  • GC01M196591

Summaries for LEFTY1 Gene

Entrez Gene Summary for LEFTY1 Gene

  • This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LEFTY1 Gene

LEFTY1 (Left-Right Determination Factor 1) is a Protein Coding gene. Diseases associated with LEFTY1 include Visceral Heterotaxy. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is LEFTY2.

UniProtKB/Swiss-Prot for LEFTY1 Gene

  • Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEFTY1 Gene

Genomics for LEFTY1 Gene

Regulatory Elements for LEFTY1 Gene

Enhancers for LEFTY1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LEFTY1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LEFTY1 Gene

Chromosome:
1
Start:
225,886,282 bp from pter
End:
225,911,382 bp from pter
Size:
25,101 bases
Orientation:
Minus strand

Genomic View for LEFTY1 Gene

Genes around LEFTY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEFTY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEFTY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEFTY1 Gene

Proteins for LEFTY1 Gene

  • Protein details for LEFTY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75610-LFTY1_HUMAN
    Recommended name:
    Left-right determination factor 1
    Protein Accession:
    O75610
    Secondary Accessions:
    • B2R7U0
    • Q53H67
    • Q5TE94

    Protein attributes for LEFTY1 Gene

    Size:
    366 amino acids
    Molecular mass:
    40880 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LEFTY1 Gene

Proteomics data for LEFTY1 Gene at MOPED

Post-translational modifications for LEFTY1 Gene

  • The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
  • Glycosylation at Asn 158
  • Modification sites at PhosphoSitePlus

Other Protein References for LEFTY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LEFTY1 (LEFTY1)

No data available for DME Specific Peptides for LEFTY1 Gene

Domains & Families for LEFTY1 Gene

Suggested Antigen Peptide Sequences for LEFTY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75610

UniProtKB/Swiss-Prot:

LFTY1_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with LEFTY1: view

No data available for Gene Families for LEFTY1 Gene

Function for LEFTY1 Gene

Molecular function for LEFTY1 Gene

UniProtKB/Swiss-Prot Function:
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

LifeMap Function Summary for LEFTY1 Gene

During embryonic development, LEFTY1 as signaling molecule is secreted from the following cells
It affects the following cells:
genes like me logo Genes that share phenotypes with LEFTY1: view

Animal Models for LEFTY1 Gene

MGI Knock Outs for LEFTY1:

Animal Model Products

miRNA for LEFTY1 Gene

miRTarBase miRNAs that target LEFTY1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LEFTY1 Gene

Localization for LEFTY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEFTY1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LEFTY1 Gene COMPARTMENTS Subcellular localization image for LEFTY1 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for LEFTY1 Gene

Pathways & Interactions for LEFTY1 Gene

genes like me logo Genes that share pathways with LEFTY1: view

Pathways by source for LEFTY1 Gene

1 Sino Biological pathway for LEFTY1 Gene
1 GeneTex pathway for LEFTY1 Gene
1 Cell Signaling Technology pathway for LEFTY1 Gene

Interacting Proteins for LEFTY1 Gene

Gene Ontology (GO) - Biological Process for LEFTY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0003007 heart morphogenesis ISS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 10053005
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
GO:0016049 cell growth IEA --
genes like me logo Genes that share ontologies with LEFTY1: view

No data available for SIGNOR curated interactions for LEFTY1 Gene

Drugs & Compounds for LEFTY1 Gene

No Compound Related Data Available

Transcripts for LEFTY1 Gene

mRNA/cDNA for LEFTY1 Gene

Unigene Clusters for LEFTY1 Gene

Left-right determination factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LEFTY1 Gene

No ASD Table

Relevant External Links for LEFTY1 Gene

GeneLoc Exon Structure for
LEFTY1
ECgene alternative splicing isoforms for
LEFTY1

Expression for LEFTY1 Gene

mRNA expression in normal human tissues for LEFTY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LEFTY1 Gene

This gene is overexpressed in Colon - Transverse (x28.9) and Pancreas (x14.6).

Protein differential expression in normal tissues from HIPED for LEFTY1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LEFTY1 Gene



SOURCE GeneReport for Unigene cluster for LEFTY1 Gene Hs.656214

genes like me logo Genes that share expression patterns with LEFTY1: view

Protein tissue co-expression partners for LEFTY1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LEFTY1 Gene

Orthologs for LEFTY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LEFTY1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Lefty1 35
  • 83.38 (n)
  • 82.37 (a)
Lefty1 16
Lefty1 36
  • 82 (a)
ManyToMany
Lefty2 36
  • 82 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LEFTY1 35
  • 99.36 (n)
  • 98.63 (a)
rat
(Rattus norvegicus)
Mammalia Lefty1 35
  • 82.15 (n)
  • 81.69 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
OneToMany
chicken
(Gallus gallus)
Aves LEFTY2 36
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lft1 36
  • 36 (a)
ManyToMany
lft2 36
  • 36 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2199 36
  • 28 (a)
OneToMany
Species with no ortholog for LEFTY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LEFTY1 Gene

ENSEMBL:
Gene Tree for LEFTY1 (if available)
TreeFam:
Gene Tree for LEFTY1 (if available)

Paralogs for LEFTY1 Gene

Paralogs for LEFTY1 Gene

(1) SIMAP similar genes for LEFTY1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LEFTY1: view

Variants for LEFTY1 Gene

Sequence variations from dbSNP and Humsavar for LEFTY1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs360057 - 225,886,863(+) GCGAG(G/T)CAGTC reference, missense
rs35273824 - 225,888,898(+) CCTCA(C/T)GTGGG reference, missense
rs145431393 - 225,888,008(+) CCTCC(A/G)ACGCC reference, missense
rs191758097 - 225,887,858(+) GGGCC(C/T)GGGCG reference, missense
rs360058 -- 225,889,219(+) AGGAG(G/T)GAGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LEFTY1 Gene

Variant ID Type Subtype PubMed ID
nsv524126 CNV Gain 19592680
nsv873231 CNV Loss 21882294
nsv520628 CNV Loss 19592680

Variation tolerance for LEFTY1 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.13; 90.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LEFTY1 Gene

Disorders for LEFTY1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LEFTY1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
visceral heterotaxy
  • heterotaxia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LEFTY1

Genetic Association Database (GAD)
LEFTY1
Human Genome Epidemiology (HuGE) Navigator
LEFTY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEFTY1
genes like me logo Genes that share disorders with LEFTY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LEFTY1 Gene

Publications for LEFTY1 Gene

  1. Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. (PMID: 10053005) Kosaki K. … Casey B. (Am. J. Hum. Genet. 1999) 2 3 4 67
  2. Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes. (PMID: 10886363) Yashiro K. … Hamada H. (Genes Cells 2000) 2 3
  3. Lefty inhibits in vitro decidualization by regulating P57 and cyclin D1 expressions. (PMID: 25339094) Li H. … Yu H. (Cell Biochem. Funct. 2014) 3
  4. Suppression of Lefty expression in induced pluripotent cancer cells. (PMID: 23407711) Saito A. … Azuma T. (FASEB J. 2013) 3
  5. Wnt3a-dependent and -independent protein interaction networks of chromatin-bound I^-catenin in mouse embryonic stem cells. (PMID: 23592333) Yakulov T. … Kemler R. (Mol. Cell Proteomics 2013) 3

Products for LEFTY1 Gene

Sources for LEFTY1 Gene

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