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Aliases for LECT1 Gene

Aliases for LECT1 Gene

  • Leukocyte Cell Derived Chemotaxin 1 2 3 5
  • Multiple Myeloma Tumor Suppressor 1 2 3
  • BRICHOS Domain Containing 3 2 3
  • Chondromodulin I 3
  • Chondromodulin-1 3
  • Chondromodulin-I 3
  • BRICD3 3
  • MYETS1 3
  • CHM-I 3
  • CHM1 3
  • CHMI 4

External Ids for LECT1 Gene

Previous HGNC Symbols for LECT1 Gene

  • MYETS1

Previous GeneCards Identifiers for LECT1 Gene

  • GC13M047272
  • GC13M052214
  • GC13M051075
  • GC13M052175
  • GC13M053277
  • GC13M033991

Summaries for LECT1 Gene

Entrez Gene Summary for LECT1 Gene

  • This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for LECT1 Gene

LECT1 (Leukocyte Cell Derived Chemotaxin 1) is a Protein Coding gene. Diseases associated with LECT1 include Chondrosarcoma and Heart Valve Disease. An important paralog of this gene is TNMD.

UniProtKB/Swiss-Prot for LECT1 Gene

  • Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.

Gene Wiki entry for LECT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LECT1 Gene

Genomics for LECT1 Gene

Regulatory Elements for LECT1 Gene

Enhancers for LECT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LECT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LECT1 Gene

Chromosome:
13
Start:
52,703,264 bp from pter
End:
52,739,812 bp from pter
Size:
36,549 bases
Orientation:
Minus strand

Genomic View for LECT1 Gene

Genes around LECT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LECT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LECT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LECT1 Gene

Proteins for LECT1 Gene

  • Protein details for LECT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75829-LECT1_HUMAN
    Recommended name:
    Leukocyte cell-derived chemotaxin 1
    Protein Accession:
    O75829
    Secondary Accessions:
    • Q5TAM4
    • Q8TAY6
    • Q9UM18

    Protein attributes for LECT1 Gene

    Size:
    334 amino acids
    Molecular mass:
    37102 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LECT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LECT1 Gene

Proteomics data for LECT1 Gene at MOPED

Post-translational modifications for LECT1 Gene

  • After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
  • Glycosylation at Asn 243
  • Modification sites at PhosphoSitePlus

Other Protein References for LECT1 Gene

Antibody Products

  • R&D Systems Antibodies for LECT1 (Chondromodulin-1)
  • Abcam antibodies for LECT1

No data available for DME Specific Peptides for LECT1 Gene

Domains & Families for LECT1 Gene

Gene Families for LECT1 Gene

Protein Domains for LECT1 Gene

Suggested Antigen Peptide Sequences for LECT1 Gene

Graphical View of Domain Structure for InterPro Entry

O75829

UniProtKB/Swiss-Prot:

LECT1_HUMAN :
  • Contains 1 BRICHOS domain.
  • Belongs to the chondromodulin-1 family.
Domain:
  • Contains 1 BRICHOS domain.
Family:
  • Belongs to the chondromodulin-1 family.
genes like me logo Genes that share domains with LECT1: view

Function for LECT1 Gene

Molecular function for LECT1 Gene

UniProtKB/Swiss-Prot Function:
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
genes like me logo Genes that share phenotypes with LECT1: view

Animal Models for LECT1 Gene

MGI Knock Outs for LECT1:

Animal Model Products

miRNA for LECT1 Gene

miRTarBase miRNAs that target LECT1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LECT1 Gene

Localization for LECT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LECT1 Gene

Chondromodulin-1: Secreted, extracellular space, extracellular matrix. Note=Accumulated in the inter-territorial matrix of cartilage.
Chondrosurfactant protein: Endomembrane system; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LECT1 Gene COMPARTMENTS Subcellular localization image for LECT1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LECT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012505 endomembrane system IEA --
genes like me logo Genes that share ontologies with LECT1: view

Pathways & Interactions for LECT1 Gene

SuperPathways for LECT1 Gene

No Data Available

Interacting Proteins for LECT1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367198%0d%0a9606.ENSP00000268171%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: ENSP00000367198 O75829-LECT1_HUMAN for LECT1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for LECT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016525 negative regulation of angiogenesis IDA 16980969
GO:0051216 cartilage development IEA --
genes like me logo Genes that share ontologies with LECT1: view

No data available for Pathways by source and SIGNOR curated interactions for LECT1 Gene

Drugs & Compounds for LECT1 Gene

(2) Drugs for LECT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for LECT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LECT1: view

Transcripts for LECT1 Gene

Unigene Clusters for LECT1 Gene

Leukocyte cell derived chemotaxin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LECT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3:

Relevant External Links for LECT1 Gene

GeneLoc Exon Structure for
LECT1
ECgene alternative splicing isoforms for
LECT1

Expression for LECT1 Gene

mRNA expression in normal human tissues for LECT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LECT1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x9.8), Brain - Caudate (basal ganglia) (x7.8), Brain - Putamen (basal ganglia) (x7.4), and Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for LECT1 Gene

This gene is overexpressed in Vitreous humor (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LECT1 Gene



SOURCE GeneReport for Unigene cluster for LECT1 Gene Hs.421391

mRNA Expression by UniProt/SwissProt for LECT1 Gene

O75829-LECT1_HUMAN
Tissue specificity: Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma.
genes like me logo Genes that share expression patterns with LECT1: view

Protein tissue co-expression partners for LECT1 Gene

- Elite partner

Primer Products

Orthologs for LECT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LECT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LECT1 35
  • 89.32 (n)
  • 92.22 (a)
LECT1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LECT1 35
  • 90.4 (n)
  • 91.29 (a)
LECT1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lect1 35
  • 86.49 (n)
  • 89.19 (a)
Lect1 16
Lect1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LECT1 35
  • 99.6 (n)
  • 99.4 (a)
LECT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lect1 35
  • 85.29 (n)
  • 89.49 (a)
oppossum
(Monodelphis domestica)
Mammalia LECT1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LECT1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves LECT1 35
  • 69.97 (n)
  • 70.87 (a)
LECT1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LECT1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lect1 35
  • 69.38 (n)
  • 69.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia lect1-prov 35
zebrafish
(Danio rerio)
Actinopterygii lect1 35
lect1 35
  • 57.82 (n)
  • 46.18 (a)
lect1 36
  • 45 (a)
OneToOne
Species with no ortholog for LECT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LECT1 Gene

ENSEMBL:
Gene Tree for LECT1 (if available)
TreeFam:
Gene Tree for LECT1 (if available)

Paralogs for LECT1 Gene

Paralogs for LECT1 Gene

(1) SIMAP similar genes for LECT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LECT1: view

Variants for LECT1 Gene

Sequence variations from dbSNP and Humsavar for LECT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs7330220 - 52,712,815(+) ATCTA(C/T)AGCCA reference, missense
rs3742298 - 52,733,227(+) CTGGA(A/G)ATCAT reference, missense
rs881482 -- 52,724,085(+) CTCCT(C/G)CAGCA intron-variant, reference, missense
rs760135 -- 52,736,907(-) ATTAT(C/T)GTAAA intron-variant
rs1052307 -- 52,703,577(+) TATCA(A/C/G/T)GTGCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LECT1 Gene

Variant ID Type Subtype PubMed ID
nsv820041 CNV Gain 19587683
esv2747426 CNV Deletion 23290073
esv4481 CNV Deletion 18987735
esv2747427 CNV Deletion 23290073
esv2668707 CNV Deletion 23128226
esv2670815 CNV Deletion 23128226
esv2747428 CNV Deletion 23290073

Variation tolerance for LECT1 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LECT1 Gene

Disorders for LECT1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LECT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chondrosarcoma
  • chondrosarcoma of bone
heart valve disease
  • valvular heart disease
- elite association - COSMIC cancer census association via MalaCards
Search LECT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LECT1

Genetic Association Database (GAD)
LECT1
Human Genome Epidemiology (HuGE) Navigator
LECT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LECT1
genes like me logo Genes that share disorders with LECT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LECT1 Gene

Publications for LECT1 Gene

  1. Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells. (PMID: 10103018) Hiraki Y. … Kondo J. (Eur. J. Biochem. 1999) 2 3 4 23 67
  2. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor. (PMID: 20026108) Miura S. … Hiraki Y. (Exp. Cell Res. 2010) 3 23
  3. Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation. (PMID: 17980151) Aoyama T. … Toguchida J. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. (PMID: 16980969) Yoshioka M. … Fukuda K. (Nat. Med. 2006) 3 23
  5. Expression of the chondromodulin-I gene in chondrosarcomas. (PMID: 14744535) Aoyama T. … Toguchida J. (Cancer Lett. 2004) 3 23

Products for LECT1 Gene

Sources for LECT1 Gene

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