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Aliases for LDOC1L Gene

Aliases for LDOC1L Gene

  • Leucine Zipper, Down-Regulated In Cancer 1-Like 2 3 5
  • Leucine Zipper Protein Down-Regulated In Cancer Cells-Like 3 4
  • Mammalian Retrotransposon-Derived Protein 6 3 4
  • Mart6 3 4
  • Mar6 3 4
  • DJ1033E15.2 3

External Ids for LDOC1L Gene

Previous GeneCards Identifiers for LDOC1L Gene

  • GC22M043168
  • GC22M043208
  • GC22M043267
  • GC22M044888
  • GC22M027837

Summaries for LDOC1L Gene

GeneCards Summary for LDOC1L Gene

LDOC1L (Leucine Zipper, Down-Regulated In Cancer 1-Like) is a Protein Coding gene. An important paralog of this gene is FAM127B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDOC1L Gene

Genomics for LDOC1L Gene

Regulatory Elements for LDOC1L Gene

Promoters for LDOC1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LDOC1L on UCSC Golden Path with GeneCards custom track

Genomic Location for LDOC1L Gene

Chromosome:
22
Start:
44,492,570 bp from pter
End:
44,498,298 bp from pter
Size:
5,729 bases
Orientation:
Minus strand

Genomic View for LDOC1L Gene

Genes around LDOC1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDOC1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDOC1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDOC1L Gene

Proteins for LDOC1L Gene

  • Protein details for LDOC1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICC9-LDOCL_HUMAN
    Recommended name:
    Protein LDOC1L
    Protein Accession:
    Q6ICC9
    Secondary Accessions:
    • Q6ZTR1

    Protein attributes for LDOC1L Gene

    Size:
    239 amino acids
    Molecular mass:
    26154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDOC1L Gene

Proteomics data for LDOC1L Gene at MOPED

Post-translational modifications for LDOC1L Gene

No Post-translational modifications

Other Protein References for LDOC1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LDOC1L Gene

Domains & Families for LDOC1L Gene

Protein Domains for LDOC1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LDOC1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ICC9

UniProtKB/Swiss-Prot:

LDOCL_HUMAN :
  • Belongs to the LDOC1 family.
Family:
  • Belongs to the LDOC1 family.
genes like me logo Genes that share domains with LDOC1L: view

No data available for Gene Families for LDOC1L Gene

Function for LDOC1L Gene

genes like me logo Genes that share phenotypes with LDOC1L: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDOC1L Gene

Localization for LDOC1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDOC1L Gene COMPARTMENTS Subcellular localization image for LDOC1L gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LDOC1L Gene

Pathways & Interactions for LDOC1L Gene

SuperPathways for LDOC1L Gene

No Data Available

Interacting Proteins for LDOC1L Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000340434%0d%0a9606.ENSP00000234170%0d%0a9606.ENSP00000447803%0d%0a9606.ENSP00000254942%0d%0a
Selected Interacting proteins: Q6ICC9-LDOCL_HUMAN ENSP00000340434 for LDOC1L Gene via I2D STRING

Gene Ontology (GO) - Biological Process for LDOC1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LDOC1L Gene

Drugs & Compounds for LDOC1L Gene

No Compound Related Data Available

Transcripts for LDOC1L Gene

mRNA/cDNA for LDOC1L Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(87) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDOC1L Gene

Leucine zipper, down-regulated in cancer 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LDOC1L Gene

No ASD Table

Relevant External Links for LDOC1L Gene

GeneLoc Exon Structure for
LDOC1L
ECgene alternative splicing isoforms for
LDOC1L

Expression for LDOC1L Gene

mRNA expression in normal human tissues for LDOC1L Gene

SOURCE GeneReport for Unigene cluster for LDOC1L Gene Hs.744991

genes like me logo Genes that share expression patterns with LDOC1L: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LDOC1L Gene

Orthologs for LDOC1L Gene

This gene was present in the common ancestor of mammals.

Orthologs for LDOC1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LDOC1L 35
  • 85.08 (n)
  • 94.14 (a)
LDOC1L 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LDOC1L 35
  • 87.59 (n)
  • 94.56 (a)
LDOC1L 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ldoc1l 35
  • 81.73 (n)
  • 93.31 (a)
Ldoc1l 16
Ldoc1l 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LDOC1L 35
  • 99.02 (n)
  • 98.74 (a)
LDOC1L 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ldoc1l 35
  • 81.03 (n)
  • 93.31 (a)
Species with no ortholog for LDOC1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LDOC1L Gene

ENSEMBL:
Gene Tree for LDOC1L (if available)
TreeFam:
Gene Tree for LDOC1L (if available)

Paralogs for LDOC1L Gene

Paralogs for LDOC1L Gene

(1) SIMAP similar genes for LDOC1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LDOC1L: view

Variants for LDOC1L Gene

Sequence variations from dbSNP and Humsavar for LDOC1L Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs131151 -- 44,494,839(+) GCTTC(-/C)ATGCT utr-variant-3-prime
rs131152 -- 44,494,847(+) GCTGG(-/G)CTGGG utr-variant-3-prime
rs131153 -- 44,494,865(+) GAAAC(-/C)TTCCA utr-variant-3-prime
rs131154 -- 44,494,965(+) CAGAA(C/G)AGAAC utr-variant-3-prime
rs131155 -- 44,495,367(+) AGCCA(A/G)GACCC utr-variant-3-prime

Variation tolerance for LDOC1L Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDOC1L Gene

HapMap Linkage Disequilibrium report
LDOC1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LDOC1L Gene

Disorders for LDOC1L Gene

Relevant External Links for LDOC1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDOC1L

No disorders were found for LDOC1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDOC1L Gene

Publications for LDOC1L Gene

  1. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J. … Volff J.-N. (Cytogenet. Genome Res. 2005) 2 3 67
  2. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 3

Products for LDOC1L Gene

Sources for LDOC1L Gene

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