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Aliases for LDOC1 Gene

Aliases for LDOC1 Gene

  • Leucine Zipper, Down-Regulated In Cancer 1 2 3
  • Leucine Zipper Protein Down-Regulated In Cancer Cells 3 4
  • BCUR1 3 4
  • Breast Cancer, Up-Regulated 1 3
  • Protein LDOC1 3
  • Mart7 3
  • Mar7 3

External Ids for LDOC1 Gene

Previous Symbols for LDOC1 Gene

  • BCUR1

Summaries for LDOC1 Gene

Entrez Gene Summary for LDOC1 Gene

  • The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for LDOC1 Gene

LDOC1 (Leucine Zipper, Down-Regulated In Cancer 1) is a Protein Coding gene. Diseases associated with LDOC1 include breast cancer. An important paralog of this gene is FAM127B.

UniProtKB/Swiss-Prot for LDOC1 Gene

  • May have an important role in the development and/or progression of some cancers

Gene Wiki entry for LDOC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDOC1 Gene

Genomics for LDOC1 Gene

Genomic Location for LDOC1 Gene

Start:
141,175,745 bp from pter
End:
141,177,214 bp from pter
Size:
1,470 bases
Orientation:
Minus strand

Genomic View for LDOC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LDOC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDOC1 Gene

Regulatory Elements for LDOC1 Gene

Proteins for LDOC1 Gene

  • Protein details for LDOC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95751-LDOC1_HUMAN
    Recommended name:
    Protein LDOC1
    Protein Accession:
    O95751
    Secondary Accessions:
    • Q6IAR6

    Protein attributes for LDOC1 Gene

    Size:
    146 amino acids
    Molecular mass:
    16968 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDOC1 Gene

Proteomics data for LDOC1 Gene at MOPED

Post-translational modifications for LDOC1 Gene

No Post-translational modifications

Other Protein References for LDOC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LDOC1 Gene

Domains for LDOC1 Gene

Protein Domains for LDOC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

LDOC1_HUMAN
Family:
  • Belongs to the LDOC1 family.:
    • O95751
genes like me logo Genes that share domains with LDOC1: view

No data available for Gene Families for LDOC1 Gene

Function for LDOC1 Gene

Molecular function for LDOC1 Gene

GENATLAS Biochemistry: gene down-regulated in some cancer cell lines
UniProtKB/Swiss-Prot Function: May have an important role in the development and/or progression of some cancers

Gene Ontology (GO) - Molecular Function for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LDOC1: view

Phenotypes for LDOC1 Gene

GenomeRNAi human phenotypes for LDOC1:
genes like me logo Genes that share phenotypes with LDOC1: view

miRNA for LDOC1 Gene

miRTarBase miRNAs that target LDOC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LDOC1 Gene

Localization for LDOC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDOC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDOC1 Gene COMPARTMENTS Subcellular localization image for LDOC1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with LDOC1: view

Pathways for LDOC1 Gene

SuperPathways for LDOC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with LDOC1: view

No data available for Pathways by source for LDOC1 Gene

Transcripts for LDOC1 Gene

mRNA/cDNA for LDOC1 Gene

Unigene Clusters for LDOC1 Gene

Leucine zipper, down-regulated in cancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LDOC1 Gene

No ASD Table

Relevant External Links for LDOC1 Gene

GeneLoc Exon Structure for
LDOC1
ECgene alternative splicing isoforms for
LDOC1

Expression for LDOC1 Gene

mRNA expression in normal human tissues for LDOC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDOC1 Gene

This gene is overexpressed in Artery - Aorta (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LDOC1 Gene

SOURCE GeneReport for Unigene cluster for LDOC1 Gene Hs.45231

mRNA Expression by UniProt/SwissProt for LDOC1 Gene

O95751-LDOC1_HUMAN
Tissue specificity: Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.
genes like me logo Genes that share expressions with LDOC1: view

Orthologs for LDOC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LDOC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDOC1 37
  • 99 (a)
OneToOne
LOC100614906 36
  • 98.86 (n)
  • 98.63 (a)
cow
(Bos Taurus)
Mammalia LDOC1 36
  • 95.28 (n)
  • 98.33 (a)
dog
(Canis familiaris)
Mammalia LDOC1 37
  • 96 (a)
OneToOne
LOC100855971 36
  • 97.71 (n)
  • 98.47 (a)
mouse
(Mus musculus)
Mammalia Ldoc1 36
  • 80.66 (n)
  • 76.34 (a)
Ldoc1 16
Ldoc1 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ldoc1 36
  • 81.93 (n)
  • 76.34 (a)
Species with no ortholog for LDOC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LDOC1 Gene

ENSEMBL:
Gene Tree for LDOC1 (if available)
TreeFam:
Gene Tree for LDOC1 (if available)

Paralogs for LDOC1 Gene

Paralogs for LDOC1 Gene

Selected SIMAP similar genes for LDOC1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for LDOC1 Gene

genes like me logo Genes that share paralogs with LDOC1: view

Variants for LDOC1 Gene

Sequence variations from dbSNP and Humsavar for LDOC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs710106 -- 141,176,233(-) CACCC(A/G)TAGCC utr-variant-3-prime
rs2038375 -- 141,177,083(-) CGAGG(C/G)CTCCG utr-variant-5-prime
rs6634234 -- 141,175,278(+) GTTGG(C/G)TATTT downstream-variant-500B
rs11551863 -- 141,175,890(+) AATTT(C/T)GAAAG utr-variant-3-prime
rs12006735 -- 141,175,461(+) ATGGT(C/T)TAATT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LDOC1 Gene

Variant ID Type Subtype PubMed ID
dgv2482e1 CNV Complex 17122850
dgv2483e1 CNV Complex 17122850
nsv7462 OTHER Inversion 18451855
nsv470368 CNV Gain 18288195
nsv470367 CNV Loss 18288195
nsv516880 CNV Gain+Loss 19592680

Relevant External Links for LDOC1 Gene

HapMap Linkage Disequilibrium report
LDOC1

Disorders for LDOC1 Gene

(1) MalaCards Diseases for LDOC1 Gene

Search for LDOC1 Gene in MalaCards »
genes like me logo Genes that share disorders with LDOC1: view

No data available for UniProtKB/Swiss-Prot for LDOC1 Gene

Publications for LDOC1 Gene

  1. Identification of a novel gene, LDOC1, down-regulated in cancer cell lines. (PMID: 10403563) Nagasaki K. … Yamaguchi K. (Cancer Lett. 1999) 2 3 4 23
  2. Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis. (PMID: 12712434) Nagasaki K. … Maass N. (Int. J. Cancer 2003) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for LDOC1 Gene

Sources for LDOC1 Gene

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