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Aliases for LDOC1 Gene

Aliases for LDOC1 Gene

  • Leucine Zipper, Down-Regulated In Cancer 1 2 3 5
  • Leucine Zipper Protein Down-Regulated In Cancer Cells 3 4
  • BCUR1 3 4
  • Leucine Zipper Downregulated In Cancer 3
  • Breast Cancer, Up-Regulated 1 3
  • Mart7 3
  • Mar7 3

External Ids for LDOC1 Gene

Previous HGNC Symbols for LDOC1 Gene

  • BCUR1

Previous GeneCards Identifiers for LDOC1 Gene

  • GC0XM134800
  • GC0XM137127
  • GC0XM138202
  • GC0XM138963
  • GC0XM139995
  • GC0XM140097
  • GC0XM140269
  • GC0XM129731

Summaries for LDOC1 Gene

Entrez Gene Summary for LDOC1 Gene

  • The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for LDOC1 Gene

LDOC1 (Leucine Zipper, Down-Regulated In Cancer 1) is a Protein Coding gene. An important paralog of this gene is FAM127B.

UniProtKB/Swiss-Prot for LDOC1 Gene

  • May have an important role in the development and/or progression of some cancers.

Gene Wiki entry for LDOC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDOC1 Gene

Genomics for LDOC1 Gene

Regulatory Elements for LDOC1 Gene

Enhancers for LDOC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LDOC1 on UCSC Golden Path with GeneCards custom track

Promoters for LDOC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LDOC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LDOC1 Gene

141,175,745 bp from pter
141,177,214 bp from pter
1,470 bases
Minus strand

Genomic View for LDOC1 Gene

Genes around LDOC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDOC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDOC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDOC1 Gene

Proteins for LDOC1 Gene

  • Protein details for LDOC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein LDOC1
    Protein Accession:
    Secondary Accessions:
    • Q6IAR6

    Protein attributes for LDOC1 Gene

    146 amino acids
    Molecular mass:
    16968 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDOC1 Gene

Proteomics data for LDOC1 Gene at MOPED

Post-translational modifications for LDOC1 Gene

No Post-translational modifications

Other Protein References for LDOC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LDOC1 Gene

Domains & Families for LDOC1 Gene

Protein Domains for LDOC1 Gene


Suggested Antigen Peptide Sequences for LDOC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LDOC1 family.
  • Belongs to the LDOC1 family.
genes like me logo Genes that share domains with LDOC1: view

No data available for Gene Families for LDOC1 Gene

Function for LDOC1 Gene

Molecular function for LDOC1 Gene

GENATLAS Biochemistry:
gene down-regulated in some cancer cell lines
UniProtKB/Swiss-Prot Function:
May have an important role in the development and/or progression of some cancers.
genes like me logo Genes that share phenotypes with LDOC1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDOC1 Gene

Localization for LDOC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDOC1 Gene

Subcellular locations from

Jensen Localization Image for LDOC1 Gene COMPARTMENTS Subcellular localization image for LDOC1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with LDOC1: view

Pathways & Interactions for LDOC1 Gene

SuperPathways for LDOC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LDOC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for LDOC1 Gene

Drugs & Compounds for LDOC1 Gene

No Compound Related Data Available

Transcripts for LDOC1 Gene

mRNA/cDNA for LDOC1 Gene

Unigene Clusters for LDOC1 Gene

Leucine zipper, down-regulated in cancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LDOC1 Gene

No ASD Table

Relevant External Links for LDOC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LDOC1 Gene

mRNA expression in normal human tissues for LDOC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDOC1 Gene

This gene is overexpressed in Artery - Aorta (x5.8).

Protein differential expression in normal tissues from HIPED for LDOC1 Gene

This gene is overexpressed in Bone (37.3) and Lung (31.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LDOC1 Gene

SOURCE GeneReport for Unigene cluster for LDOC1 Gene Hs.45231

mRNA Expression by UniProt/SwissProt for LDOC1 Gene

Tissue specificity: Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.
genes like me logo Genes that share expression patterns with LDOC1: view

Protein tissue co-expression partners for LDOC1 Gene

- Elite partner

Primer Products

Orthologs for LDOC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LDOC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LDOC1 35
  • 95.28 (n)
  • 98.33 (a)
(Canis familiaris)
Mammalia LOC100855971 35
  • 97.71 (n)
  • 98.47 (a)
LDOC1 36
  • 96 (a)
(Mus musculus)
Mammalia Ldoc1 35
  • 80.66 (n)
  • 76.34 (a)
Ldoc1 16
Ldoc1 36
  • 72 (a)
(Pan troglodytes)
Mammalia LOC100614906 35
  • 98.86 (n)
  • 98.63 (a)
LDOC1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ldoc1 35
  • 81.93 (n)
  • 76.34 (a)
Species with no ortholog for LDOC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LDOC1 Gene

Gene Tree for LDOC1 (if available)
Gene Tree for LDOC1 (if available)

Paralogs for LDOC1 Gene

Paralogs for LDOC1 Gene

(5) SIMAP similar genes for LDOC1 Gene using alignment to 2 proteins: Pseudogenes for LDOC1 Gene

genes like me logo Genes that share paralogs with LDOC1: view

Variants for LDOC1 Gene

Sequence variations from dbSNP and Humsavar for LDOC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs710106 -- 141,176,233(-) CACCC(A/G)TAGCC utr-variant-3-prime
rs2038375 -- 141,177,083(-) CGAGG(C/G)CTCCG utr-variant-5-prime
rs2144603 -- 141,178,367(-) cgagt(A/G)gctgg upstream-variant-2KB
rs2144604 -- 141,178,298(-) TTTCA(C/G)CCTGT upstream-variant-2KB
rs5907829 -- 141,178,474(+) actcc(A/G)tttca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LDOC1 Gene

Variant ID Type Subtype PubMed ID
dgv2482e1 CNV Complex 17122850
dgv2483e1 CNV Complex 17122850
nsv7462 OTHER Inversion 18451855
nsv470368 CNV Gain 18288195
nsv470367 CNV Loss 18288195
nsv516880 CNV Gain+Loss 19592680

Variation tolerance for LDOC1 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LDOC1 Gene

Disorders for LDOC1 Gene

Relevant External Links for LDOC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LDOC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDOC1 Gene

Publications for LDOC1 Gene

  1. Identification of a novel gene, LDOC1, down-regulated in cancer cell lines. (PMID: 10403563) Nagasaki K. … Yamaguchi K. (Cancer Lett. 1999) 2 3 4 23 67
  2. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3
  3. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J. … Volff J.-N. (Cytogenet. Genome Res. 2005) 2 3
  4. Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis. (PMID: 12712434) Nagasaki K. … Maass N. (Int. J. Cancer 2003) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for LDOC1 Gene

Sources for LDOC1 Gene