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Aliases for LDOC1 Gene

Aliases for LDOC1 Gene

  • Leucine Zipper Down-Regulated In Cancer 1 2 3 5
  • Leucine Zipper Protein Down-Regulated In Cancer Cells 3 4
  • BCUR1 3 4
  • Leucine Zipper Downregulated In Cancer 3
  • Breast Cancer, Up-Regulated 1 3
  • Protein LDOC1 3
  • Mart7 3
  • Mar7 3

External Ids for LDOC1 Gene

Previous HGNC Symbols for LDOC1 Gene

  • BCUR1

Previous GeneCards Identifiers for LDOC1 Gene

  • GC0XM134800
  • GC0XM137127
  • GC0XM138202
  • GC0XM138963
  • GC0XM139995
  • GC0XM140097
  • GC0XM140269
  • GC0XM129731

Summaries for LDOC1 Gene

Entrez Gene Summary for LDOC1 Gene

  • The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for LDOC1 Gene

LDOC1 (Leucine Zipper Down-Regulated In Cancer 1) is a Protein Coding gene. An important paralog of this gene is FAM127B.

UniProtKB/Swiss-Prot for LDOC1 Gene

  • May have an important role in the development and/or progression of some cancers.

Gene Wiki entry for LDOC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDOC1 Gene

Genomics for LDOC1 Gene

Regulatory Elements for LDOC1 Gene

Enhancers for LDOC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF141176 0.6 ENCODE 17.9 +0.1 77 1.0 ZNF687 PHF8 SP3 TAF1 L3MBTL2 NRF1 MAX SIN3A TFDP1 POLR2A LDOC1 ENSG00000261212
GH0XF141219 0.7 ENCODE 0.2 -43.5 -43492 1.7 JUND JUN STAT3 CUX1 DPF2 FOS FOSL2 EP300 GC0XP141237 LDOC1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LDOC1 on UCSC Golden Path with GeneCards custom track

Promoters for LDOC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000161414 413 1999 ZNF687 PHF8 SP3 TAF1 L3MBTL2 MAX SIN3A TFDP1 POLR2A ZNF341

Genomic Location for LDOC1 Gene

Chromosome:
X
Start:
141,175,745 bp from pter
End:
141,177,214 bp from pter
Size:
1,470 bases
Orientation:
Minus strand

Genomic View for LDOC1 Gene

Genes around LDOC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDOC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDOC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDOC1 Gene

Proteins for LDOC1 Gene

  • Protein details for LDOC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95751-LDOC1_HUMAN
    Recommended name:
    Protein LDOC1
    Protein Accession:
    O95751
    Secondary Accessions:
    • Q6IAR6

    Protein attributes for LDOC1 Gene

    Size:
    146 amino acids
    Molecular mass:
    16968 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDOC1 Gene

Post-translational modifications for LDOC1 Gene

No Post-translational modifications

Other Protein References for LDOC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LDOC1 Gene

Domains & Families for LDOC1 Gene

Protein Domains for LDOC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LDOC1 Gene

Graphical View of Domain Structure for InterPro Entry

O95751

UniProtKB/Swiss-Prot:

LDOC1_HUMAN :
  • Belongs to the LDOC1 family.
Family:
  • Belongs to the LDOC1 family.
genes like me logo Genes that share domains with LDOC1: view

No data available for Gene Families for LDOC1 Gene

Function for LDOC1 Gene

Molecular function for LDOC1 Gene

GENATLAS Biochemistry:
gene down-regulated in some cancer cell lines
UniProtKB/Swiss-Prot Function:
May have an important role in the development and/or progression of some cancers.

Gene Ontology (GO) - Molecular Function for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LDOC1: view
genes like me logo Genes that share phenotypes with LDOC1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDOC1 Gene

Localization for LDOC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDOC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDOC1 Gene COMPARTMENTS Subcellular localization image for LDOC1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with LDOC1: view

Pathways & Interactions for LDOC1 Gene

SuperPathways for LDOC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LDOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001893 maternal placenta development IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0060137 maternal process involved in parturition IEA --
GO:1903547 regulation of growth hormone activity IEA --
genes like me logo Genes that share ontologies with LDOC1: view

No data available for Pathways by source and SIGNOR curated interactions for LDOC1 Gene

Transcripts for LDOC1 Gene

mRNA/cDNA for LDOC1 Gene

Unigene Clusters for LDOC1 Gene

Leucine zipper, down-regulated in cancer 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDOC1 Gene

No ASD Table

Relevant External Links for LDOC1 Gene

GeneLoc Exon Structure for
LDOC1
ECgene alternative splicing isoforms for
LDOC1

Expression for LDOC1 Gene

mRNA expression in normal human tissues for LDOC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDOC1 Gene

This gene is overexpressed in Artery - Aorta (x5.8).

Protein differential expression in normal tissues from HIPED for LDOC1 Gene

This gene is overexpressed in Bone (37.3) and Lung (31.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LDOC1 Gene



Protein tissue co-expression partners for LDOC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LDOC1 Gene:

LDOC1

SOURCE GeneReport for Unigene cluster for LDOC1 Gene:

Hs.45231

mRNA Expression by UniProt/SwissProt for LDOC1 Gene:

O95751-LDOC1_HUMAN
Tissue specificity: Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.
genes like me logo Genes that share expression patterns with LDOC1: view

Primer Products

Orthologs for LDOC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LDOC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDOC1 35
  • 99 (a)
OneToOne
LOC100614906 34
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia LOC100855971 34
  • 97.71 (n)
LDOC1 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LDOC1 34
  • 95.28 (n)
rat
(Rattus norvegicus)
Mammalia Ldoc1 34
  • 81.93 (n)
mouse
(Mus musculus)
Mammalia Ldoc1 34 16 35
  • 80.66 (n)
Species where no ortholog for LDOC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LDOC1 Gene

ENSEMBL:
Gene Tree for LDOC1 (if available)
TreeFam:
Gene Tree for LDOC1 (if available)

Paralogs for LDOC1 Gene

Paralogs for LDOC1 Gene

(5) SIMAP similar genes for LDOC1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for LDOC1 Gene

genes like me logo Genes that share paralogs with LDOC1: view

Variants for LDOC1 Gene

Sequence variations from dbSNP and Humsavar for LDOC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111271141 -- 141,176,655(+) CTCAT(C/T)GAGGA reference, missense
rs111880544 -- 141,175,445(+) GTTTA(C/T)GCCTA downstream-variant-500B
rs113746376 -- 141,177,202(+) GACGG(A/C)CGGTG utr-variant-5-prime
rs11551863 -- 141,175,890(+) AATTT(C/T)GAAAG utr-variant-3-prime
rs12006735 -- 141,175,461(+) ATGGT(C/T)TAATT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LDOC1 Gene

Variant ID Type Subtype PubMed ID
esv2758896 CNV gain+loss 17122850
esv3577441 CNV gain 25503493
nsv470367 CNV loss 18288195
nsv470368 CNV gain 18288195
nsv516880 CNV gain+loss 19592680
nsv7462 OTHER inversion 18451855

Variation tolerance for LDOC1 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDOC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDOC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDOC1 Gene

Disorders for LDOC1 Gene

Relevant External Links for LDOC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDOC1

No disorders were found for LDOC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDOC1 Gene

Publications for LDOC1 Gene

  1. Identification of a novel gene, LDOC1, down-regulated in cancer cell lines. (PMID: 10403563) Nagasaki K. … Yamaguchi K. (Cancer Lett. 1999) 2 3 4 22 64
  2. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3 64
  3. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J. … Volff J.-N. (Cytogenet. Genome Res. 2005) 2 3 64
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for LDOC1 Gene

Sources for LDOC1 Gene

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