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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LDOC1 Gene

protein-coding GIFtS: 51
GCID: GC0XM140269

leucine zipper, down-regulated in cancer 1

(Previous symbol: BCUR1)

Explore 8 diseases affiliated with
LDOC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leucine Zipper, Down-Regulated In Cancer 1¹ ²		Leucine Zipper Protein Down-Regulated In Cancer Cells² ³
BCUR1¹ ² ³		Breast Cancer, Up-Regulated 1²
Mar7¹ ²		Protein LDOC1²
Mart7¹ ²

External Ids:	HGNC: 6548¹	Entrez Gene: 23641²	Ensembl: ENSG00000182195⁷	OMIM: 300402⁵	UniProtKB: O95751³

Export aliases for LDOC1 gene to outside databases

Previous GC identifers: GC0XM134800 GC0XM137127 GC0XM138202 GC0XM138963 GC0XM139995 GC0XM140097 GC0XM129731

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LDOC1:

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked

similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell

lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The

gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development

and/or progression of some cancers. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LDOC1_HUMAN, O95751

Function: May have an important role in the development and/or progression of some cancers

Gene Wiki entry for LDOC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011786.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LDOC1 gene promoter:
AP-1 ATF-2 AP-2gamma FOXL1 Egr-4 COMP1 AP-2beta c-Jun AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LDOC1 promoter sequence

Search SABiosciences Chromatin IP Primers for LDOC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDOC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27 Ensembl cytogenetic band: Xq27.1 HGNC cytogenetic band: Xq27

LDOC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LDOC1 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM140269: view genomic region (about GC identifiers)

Start:	140,269,930 bp from pter	End:	140,271,310 bp from pter
Size:	1,381 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LDOC1_HUMAN, O95751 (See protein sequence)

Recommended Name: Protein LDOC1

Size: 146 amino acids; 16968 Da

Subcellular location: Nucleus

Secondary accessions: Q6IAR6

Explore the universe of human proteins at neXtProt for LDOC1: NX_O95751

LDOC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036449.1

ENSEMBL proteins:

ENSP00000359557

Human Recombinant Protein Products for LDOC1:

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	Uscn Proteins for LDOC1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

LDOC1 for ontologies About GeneDecksing

LDOC1 Antibody Products:

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Assay Products for LDOC1:

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	Uscn ELISAs and CLIAs for LDOC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: O95751

UniProtKB/Swiss-Prot: LDOC1_HUMAN, O95751

Similarity: Belongs to the LDOC1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LDOC1_HUMAN, O95751

Function: May have an important role in the development and/or progression of some cancers

Genatlas biochemistry entry for LDOC1:

gene down-regulated in some cancer cell lines

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19060904

LDOC1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for LDOC1:

Decreased influenza A virus in

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LDOC1

miRNA Products:		miRTarBase miRNAs that target LDOC1: hsa-mir-155 (MIRT001805)

		OriGene 3'-UTR Clone: LDOC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LDOC1
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate LDOC1 (see all 21):
		hsa-miR-520f hsa-miR-330-5p hsa-miR-15a hsa-miR-512-3p hsa-miR-105 hsa-miR-1184 hsa-miR-424 hsa-miR-133a

		SwitchGear 3'UTR luciferase reporter plasmid: LDOC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LDOC1 (see all 4) OriGene shRNA RFP: LDOC1 OriGene siRNA: LDOC1
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LDOC1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LDOC1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sirion Biotech Customized stable knockdown cell line services for LDOC1 Sirion Biotech Customized inducible knockdown cell line services for LDOC1 Sirion Biotech Customized stable overexpressing cell line services for LDOC1 Sirion Biotech Customized inducible overexpressing cell line services for LDOC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDOC1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LDOC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/58 Interacting proteins for LDOC1 (O95751^{1, 2, 3} ENSP00000359557⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 58)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABLIM1	O14639¹^,²^,³, ENSP00000338190⁴	EBI-740738,EBI-487024 MINT-67267 I2D: score=6 STRING: ENSP00000338190
FOSL1	P15407¹^,²^,³, ENSP00000310170⁴	EBI-740738,EBI-744510 MINT-66527 I2D: score=5 STRING: ENSP00000310170
FXR2	P51116¹^,²^,³, ENSP00000250113⁴	EBI-740738,EBI-740459 MINT-67665 I2D: score=5 STRING: ENSP00000250113
NRIP1	P48552¹^,²^,³, ENSP00000327213⁴	EBI-740738,EBI-746484 MINT-66849 I2D: score=5 STRING: ENSP00000327213
AATF	Q9NY61²^,³, ENSP00000225402⁴	MINT-67077 I2D: score=5 STRING: ENSP00000225402

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008285	negative regulation of cell proliferation	TAS	10403563

LDOC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LDOC1
Search CenterWatch for drugs/clinical trials and news about LDOC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LDOC1 gene:

NM_012317.2

Unigene Cluster for LDOC1:

Leucine zipper, down-regulated in cancer 1

Hs.45231 [show with all ESTs]

Unigene Representative Sequence: BQ279187

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000460721 ENST00000370526(uc004fbj.3)

miRNA Products:		OriGene 3'-UTR Clone: LDOC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LDOC1
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate LDOC1 (see all 21):
		hsa-miR-520f hsa-miR-330-5p hsa-miR-15a hsa-miR-512-3p hsa-miR-105 hsa-miR-1184 hsa-miR-424 hsa-miR-133a

		SwitchGear 3'UTR luciferase reporter plasmid: LDOC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against LDOC1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LDOC1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LDOC1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LDOC1 (NM_012317)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LDOC1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDOC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDOC1

Additional cDNA sequence:

AB019527.1 AF086537.1 BC003104.1 CR457088.1 HQ343285.1

6 DOTS entries:

DT.112146 DT.100775171 DT.92325173 DT.100775169 DT.117281 DT.121282000

24/113 AceView cDNA sequences (see all 113):

CB149290 W95878 CR598988 AI859054 BG222821 NM_012317 AW439833 AI953550

CR609965 BX109007 BG151525 AI880358 AI199403 AA378389 BE766026 AI500567

BU740963 AW651785 AW157055 AF086537 BF663250 AI912419 AI560499 AI859059

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LDOC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGTGGCAT

About this image

LDOC1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Cholinergic Amacrine Cells

Amacrine, Retina

Placenta

Chorioallantoic Placenta

Extraembryonic Angioblasts

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LDOC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LDOC1

SOURCE GeneReport for Unigene cluster: Hs.45231

UniProtKB/Swiss-Prot: LDOC1_HUMAN, O95751

Tissue specificity: Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver

and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined

SABiosciences Custom PCR Arrays for LDOC1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDOC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDOC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for LDOC1 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ldoc1^{1 , 5}	leucine zipper, down-regulated in cancer 1^{1, 5}	79.49(n)¹ 76.22(a)¹		X (34.57 cM)⁵ 434784¹ NM_001018087.1¹ NP_001018097.1¹ 61709497⁵

ENSEMBL Gene Tree for LDOC1 (if available)
TreeFam Gene Tree for LDOC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LDOC1 gene

RGAG4² FAM127C² LDOC1L² FAM127B² FAM127A²

5 SIMAP similar genes for LDOC1 using alignment to 2 protein entries: LDOC1_HUMAN (see all proteins):

FAM127C FAM127A FAM127B LDOC1L RGAG4

LDOC1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for LDOC1
PGOHUM00000262998

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12115868^1,2	C	--	140269451(+)	`TGAAAG/ATGACA`	1	--	ds500¹		1		NA	2
rs73590465^1,2	C	--	140269486(+)	`TGACAG/ATCTAC`	1	--	ds500¹		1		WA	2
rs192505736^1,2		--	140269499(+)	`TGTTGG/TCTCTC`	1	--	ds500¹		0	--	--	--	--
rs147357523^1,2		--	140269618(+)	`ATATAC/TGTCCA`	1	--	ds500¹		0	--	--	--	--
rs111880544^1,2	C	--	140269630(+)	`GTTTAT/CGCCTA`	1	--	ds500¹		1		CSA	1
rs12006735^1,2	C,F,H	--	140269646(+)	`ATGGTC/TTAATT`	1	--	ds500¹		1		NA	4
rs145295312^1,2		--	140269742(+)	`GCTTTA/GAGAAA`	1	--	ds500¹		0	--	--	--	--
rs149189294^1,2		--	140269774(+)	`AGAACC/GCTGAC`	1	--	ds500¹		0	--	--	--	--
rs184550081^1,2		--	140269860(+)	`TTCCAC/TGGGAA`	1	--	ds500¹		0	--	--	--	--
rs11551863^1,2	C	--	140270075(+)	`AATTTC/TGAAAG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LDOC1 (140269930 - 140271310 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for LDOC1
2 CNVs: 4175 34509
1 Inversion: 37352

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LDOC1

DNA2.0 Custom Variant and Variant Library Synthesis for LDOC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LDOC1 for disorders           About GeneDecksing

OMIM gene information: 300402    OMIM disorders: --

8 diseases for LDOC1:    About MalaCards

breast cancer chronic lymphocytic leukemia lymphocytic leukemia cryptorchidism

pancreatic cancer leukemia pancreatitis thyroiditis

Export disorders for LDOC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LDOC1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with LDOC1)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel gene, LDOC1, down-regulated in cancer cell lines. (PubMed id 10403563)^{1, 2, 3, 9} Nagasaki K....Yamaguchi K. (1999)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PubMed id 16093683)^{1, 3} Brandt J....Volff J.N. (2005)
Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PubMed id 15716091)^{1, 3} Brandt J.... Volff J.-N. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis. (PubMed id 12712434)^{1, 9} Nagasaki K....Maass N. (2003)
Expression of LDOC1 mRNA in leucocytes of patients wit h Down's syndrome. (PubMed id 22546831)¹ Salemi M....Bosco P. (2012)
Two proapoptotic genes are downregulated in a patient with melanoma and repeated in-transit metastases. (PubMed id 21986234)¹ Salemi M....Calogero A.E. (2012)
LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patients. (PubMed id 21310924)¹ Duzkale H.... Abruzzo L.V. (2011)
Over expression of LDOC1 and PARP1, two pro-apoptotic genes, in a patient with cryptorchidism and DiGeorge anomaly. (PubMed id 21547351)¹ Salemi M....Calogero A.E. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23641	HGNC: 6548	AceView: LDOC1	Ensembl:ENSG00000182195	euGenes: HUgn23641
ECgene: LDOC1	H-InvDB: LDOC1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LDOC1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LDOC1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LDOC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LDOC1 gene:
Search GeneIP for patents involving LDOC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	OriGene Antibodies for LDOC1		OriGene shRNA RFP for LDOC1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LDOC1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LDOC1
	OriGene Protein Over-expression Lysate for LDOC1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for LDOC1		OriGene 3'-UTR Clone for LDOC1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LDOC1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LDOC1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for LDOC1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for LDOC1		OriGene Custom Protein Services for LDOC1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LDOC1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LDOC1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDOC1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LDOC1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDOC1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDOC1

	GenScript Custom Purified and Recombinant Proteins Services for LDOC1		GenScript cDNA clones with any tag delivered in your preferred vector for LDOC1
	GenScript Custom Assay Services for LDOC1		GenScript Custom Superior Antibodies Services for LDOC1
	GenScript Custom overexpressing Cell Line Services for LDOC1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in LDOC1 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	LDOC1 antibodies
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	Antibodies for LDOC1
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Browse ProSpec Recombinant Proteins

LDOC1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for LDOC1

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDOC1

	SwitchGear 3'UTR luciferase reporter plasmids for LDOC1
	SwitchGear Promoter luciferase reporter plasmids for LDOC1

Search ThermoFisher Antibodies for LDOC1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDOC1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LDOC1

Sirion Biotech Customized:

	stable knockdown cell line services for LDOC1
	inducible knockdown cell line services for LDOC1
	design and validation of potent shRNA sequences against LDOC1
	adenovirus for potent knockdown of LDOC1
	adenovirus for overexpression of LDOC1
	stable overexpressing cell line services for LDOC1
	inducible overexpressing cell line services for LDOC1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LDOC1 gene at Home site.

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LDOC1 Gene

leucine zipper, down-regulated in cancer 1

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LDOC1 Gene

leucine zipper, down-regulated in cancer 1

Aliasesfor LDOC1 gene

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Specialized Databases showing LDOC1 gene

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for LDOC1 gene

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for LDOC1 gene

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for LDOC1 gene

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for LDOC1 gene

Pathways & Interactions
for LDOC1 gene

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for LDOC1 gene

Transcripts
for LDOC1 gene

Expression
for LDOC1 gene

Orthologs
for LDOC1 gene

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for LDOC1 gene

Genomic Variants
for LDOC1 gene

Disorders / Diseases
for LDOC1 gene

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for LDOC1 gene

Intellectual Property
for LDOC1 gene

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for LDOC1 gene