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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LDOC1 Gene

protein-coding   GIFtS: 51
GCID: GC0XM140269

Leucine Zipper, Down-Regulated In Cancer 1


(Previous symbol: BCUR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine Zipper, Down-Regulated In Cancer 11 2     Mart72
BCUR11 2 3     Breast Cancer, Up-Regulated 12
Leucine Zipper Protein Down-Regulated In Cancer Cells2 3     Protein LDOC12
Mar72     

External Ids:    HGNC: 65481   Entrez Gene: 236412   Ensembl: ENSG000001821957   OMIM: 3004025   UniProtKB: O957513   

Export aliases for LDOC1 gene to outside databases

Previous GC identifers: GC0XM134800 GC0XM137127 GC0XM138202 GC0XM138963 GC0XM139995 GC0XM140097 GC0XM129731


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LDOC1 Gene:
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked
similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer
cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B
(NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important
role in the development and/or progression of some cancers. (provided by RefSeq, Jul 2008)

GeneCards Summary for LDOC1 Gene: 
LDOC1 (leucine zipper, down-regulated in cancer 1) is a protein-coding gene. Diseases associated with LDOC1 include cryptorchidism, and chronic lymphocytic leukemia. GO annotations related to this gene include protein binding. An important paralog of this gene is FAM127C.

UniProtKB/Swiss-Prot: LDOC1_HUMAN, O95751
Function: May have an important role in the development and/or progression of some cancers

Gene Wiki entry for LDOC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LDOC1 gene promoter:
         AP-1   ATF-2   AP-2gamma   FOXL1   Egr-4   COMP1   AP-2beta   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLDOC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LDOC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDOC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27   Ensembl cytogenetic band:  Xq27.1   HGNC cytogenetic band: Xq27

LDOC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LDOC1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM140269:  view genomic region     (about GC identifiers)

Start:
140,269,930 bp from pter      End:
140,271,310 bp from pter
Size:
1,381 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LDOC1_HUMAN, O95751 (See protein sequence)
Recommended Name: Protein LDOC1  
Size: 146 amino acids; 16968 Da
Subcellular location: Nucleus
Secondary accessions: Q6IAR6

Explore the universe of human proteins at neXtProt for LDOC1: NX_O95751

Explore proteomics data for LDOC1 at MOPED 

LDOC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

LDOC1 Protein Expression

REFSEQ proteins: NP_036449.1  
ENSEMBL proteins: 
 ENSP00000359557  

Human Recombinant Protein Products for LDOC1: 
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Novus Biologicals LDOC1 Proteins
Novus Biologicals LDOC1 Lysates
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Cloud-Clone Corp. Proteins for LDOC1 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

LDOC1 for ontologies           About GeneDecksing



LDOC1 Antibody Products: 
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Cloud-Clone Corp. CLIAs for LDOC1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: O95751

UniProtKB/Swiss-Prot: LDOC1_HUMAN, O95751
Similarity: Belongs to the LDOC1 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: LDOC1_HUMAN, O95751
Function: May have an important role in the development and/or progression of some cancers

     Genatlas biochemistry entry for LDOC1:
gene down-regulated in some cancer cell lines

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI16189514
     
LDOC1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for LDOC1:
 Decreased influenza A virus in 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for LDOC1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LDOC1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LDOC1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LDOC1 

miRNA
Products:
    
miRTarBase miRNAs that target LDOC1:
hsa-mir-155 (MIRT001805)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LDOC1
8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate LDOC1 (see all 21):
hsa-miR-520f hsa-miR-330-5p hsa-miR-15a hsa-miR-512-3p hsa-miR-105 hsa-miR-1184 hsa-miR-424 hsa-miR-133a
SwitchGear 3'UTR luciferase reporter plasmidLDOC1 3' UTR sequence
Inhib. RNA
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LDOC1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for LDOC1
Sirion Biotech Customized adenovirus for overexpression of LDOC1

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for LDOC1 (see all 7)
OriGene ORF clones in mouse, rat for LDOC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LDOC1 (NM_012317)
Sino Biological Human cDNA Clone for LDOC1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDOC1
Sirion Biotech Customized lentivirus for stable overexpression of LDOC1 
                     Customized lentivirus expression plasmids for stable overexpression of LDOC1 

Cell Line
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GenScript Custom overexpressing Cell Line Services for LDOC1
Search LifeMap BioReagents cell lines for LDOC1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDOC1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LDOC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for LDOC1 (O957511, 2, 3 ENSP000003595574) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
InteractantInteraction Details
GeneCardExternal ID(s)
FOSL1P154071, 2, 3, ENSP000003101704EBI-740738,EBI-744510 MINT-66527 I2D: score=5 STRING: ENSP00000310170
FXR2P511161, 2, 3, ENSP000002501134EBI-740738,EBI-740459 MINT-67665 I2D: score=5 STRING: ENSP00000250113
NRIP1P485521, 2, 3, ENSP000003272134EBI-740738,EBI-746484 MINT-66849 I2D: score=5 STRING: ENSP00000327213
ABLIM1O146391, 2, 3EBI-740738,EBI-487024 MINT-67267 I2D: score=6 
AATFQ9NY612, 3, ENSP000002254024MINT-67077 I2D: score=5 STRING: ENSP00000225402
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008285negative regulation of cell proliferation TAS10403563

LDOC1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LDOC1

Search CenterWatch for drugs/clinical trials and news about LDOC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LDOC1 gene: 
NM_012317.3  

Unigene Cluster for LDOC1:

Leucine zipper, down-regulated in cancer 1
Hs.45231  [show with all ESTs]
Unigene Representative Sequence: BQ279187
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000460721 ENST00000370526(uc004fbj.3)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LDOC1
8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate LDOC1 (see all 21):
hsa-miR-520f hsa-miR-330-5p hsa-miR-15a hsa-miR-512-3p hsa-miR-105 hsa-miR-1184 hsa-miR-424 hsa-miR-133a
SwitchGear 3'UTR luciferase reporter plasmidLDOC1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for LDOC1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LDOC1
Clone
Products:
     
OriGene clones in human, mouse for LDOC1 (see all 7)
OriGene ORF clones in mouse, rat for LDOC1
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GenScript: all cDNA clones in your preferred vector: LDOC1 (NM_012317)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LDOC1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDOC1
Sirion Biotech Customized lentivirus for stable overexpression of LDOC1 
                     Customized lentivirus expression plasmids for stable overexpression of LDOC1 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for LDOC1
OriGene qSTAR qPCR primer pairs in human, mouse for LDOC1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LDOC1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDOC1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDOC1

Additional mRNA sequence: 

AB019527.1 AF086537.1 BC003104.1 CR457088.1 HQ343285.1 

6 DOTS entries:

DT.112146  DT.100775171  DT.92325173  DT.100775169  DT.117281  DT.121282000 

24/113 AceView cDNA sequences (see all 113):

AW651785 AW439833 BG151525 AI953550 BX109007 BG222821 AI880358 W95878 
BU740963 BE766026 AI859054 AF086537 CB149290 CR598988 AW157055 CR609965 
NM_012317 AA378389 AI500567 AI199403 CA495406 AL538767 BU681888 AI859059 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LDOC1 expression in normal human tissues (normalized intensities)      LDOC1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGGTGGCAT
LDOC1 Expression
About this image


LDOC1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Spinal Cord (Nervous System)
         motor neurons   
 
 Eye (Sensory Organs)
         Cholinergic Amacrine Cells Inner Nuclear Layer
 
 Placenta (Extraembryonic Tissues)

See LDOC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LDOC1

SOURCE GeneReport for Unigene cluster: Hs.45231

UniProtKB/Swiss-Prot: LDOC1_HUMAN, O95751
Tissue specificity: Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta,
liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined

    SABiosciences Custom PCR Arrays for LDOC1
Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDOC1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDOC1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDOC1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for LDOC1 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ldoc11 , 5 leucine zipper, down-regulated in cancer 11, 5 79.49(n)1
76.22(a)1
  X (34.57 cM)5
4347841  NM_001018087.11  NP_001018097.11 
 617094975 


ENSEMBL Gene Tree for LDOC1 (if available)
TreeFam Gene Tree for LDOC1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for LDOC1 gene
FAM127C2  RGAG42  LDOC1L2  FAM127B2  FAM127A2  
5 SIMAP similar genes for LDOC1 using alignment to 2 protein entries:     LDOC1_HUMAN (see all proteins):
FAM127C    FAM127A    FAM127B    LDOC1L    RGAG4

LDOC1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for LDOC1
PGOHUM00000262998


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/54 SNPs in LDOC1 are shown (see all 54)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs121158681,2
C--140269451(+) TGAAAG/ATGACA 1 -- ds50011Minor allele frequency- A:0.00NA 2
rs735904651,2
C,F--140269486(+) TGACAG/ATCTAC 1 -- ds50011Minor allele frequency- A:0.50WA 2
rs1925057361,2
--140269499(+) TGTTGG/TCTCTC 1 -- ds50010--------
rs1473575231,2
--140269618(+) ATATAC/TGTCCA 1 -- ds50010--------
rs1118805441,2
C,F--140269630(+) GTTTAT/CGCCTA 1 -- ds50011Minor allele frequency- C:0.00CSA 1
rs120067351,2
C,F,H--140269646(+) ATGGTC/TTAATT 1 -- ds50011Minor allele frequency- T:0.50NA 4
rs1452953121,2
--140269742(+) GCTTTA/GAGAAA 1 -- ds50010--------
rs1491892941,2
--140269774(+) AGAACC/GCTGAC 1 -- ds50010--------
rs1845500811,2
--140269860(+) TTCCAC/TGGGAA 1 -- ds50010--------
rs115518631,2
C--140270075(+) AATTTC/TGAAAG 1 -- ut310--------

HapMap Linkage Disequilibrium report for LDOC1 (140269930 - 140271310 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for LDOC1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv470367CNV Loss18288195
nsv470368CNV Gain18288195
nsv516880CNV Gain+Loss19592680
dgv2483e1CNV Complex17122850
dgv2482e1CNV Complex17122850
nsv7462OTHER Inversion18451855

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing LDOC1
DNA2.0 Custom Variant and Variant Library Synthesis for LDOC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 300402    OMIM disorders: --

9 diseases for LDOC1:    About MalaCards
cryptorchidism    chronic lymphocytic leukemia    breast cancer    pancreatic cancer
down syndrome    pancreatitis    thyroiditis    leukemia
melanoma


LDOC1 for disorders           About GeneDecksing


Export disorders for LDOC1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for LDOC1 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with LDOC1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel gene, LDOC1, down-regulated in cancer cell lines. (PubMed id 10403563)1, 2, 3, 9 Nagasaki K....Yamaguchi K. (1999)
  2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
  3. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PubMed id 15716091)1, 3 Brandt J.... Volff J.-N. (2005)
  4. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PubMed id 16093683)1, 3 Brandt J....Volff J.N. (2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis. (PubMed id 12712434)1, 9 Nagasaki K....Maass N. (2003)
  7. Epigenetic regulation of the X-linked tumour suppresso rs BEX1 and LDOC1 in oral squamous cell carcinoma. (PubMed id 23362108)1 Lee C.H....Chang J.Y. (2013)
  8. Two proapoptotic genes are downregulated in a patient with melanoma and repeated in-transit metastases. (PubMed id 21986234)1 Salemi M....Calogero A.E. (2012)
  9. Expression of LDOC1 mRNA in leucocytes of patients wit h Down's syndrome. (PubMed id 22546831)1 Salemi M....Bosco P. (2012)
  10. LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patients. (PubMed id 21310924)1 Duzkale H.... Abruzzo L.V. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 23641 HGNC: 6548 AceView: LDOC1 Ensembl:ENSG00000182195 euGenes: HUgn23641
ECgene: LDOC1 H-InvDB: LDOC1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for LDOC1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LDOC1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for LDOC1 gene:
Search GeneIP for patents involving LDOC1

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore Custom Antibody & Bulk Services
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 OriGene Antibodies for LDOC1   OriGene RNAi products in human, mouse, rat for LDOC1  
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 OriGene Custom Antibody Services for LDOC1   OriGene Custom Protein Services for LDOC1  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LDOC1
 QIAGEN SeqTarget long-range PCR primers for resequencing LDOC1
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 Regulatory tfbs in LDOC1 promoter
 Search Chromatin IP Primers for LDOC1
 RT2 qPCR Primer Assay in human, mouse, rat LDOC1
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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 Proteins for LDOC1
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 ELISAs for LDOC1
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 Search LifeMap BioReagents cell lines for LDOC1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDOC1
 SwitchGear 3'UTR luciferase reporter plasmids for LDOC1
 SwitchGear Promoter luciferase reporter plasmids for LDOC1
 Search ThermoFisher Antibodies for LDOC1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDOC1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for LDOC1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LDOC1
Customized:
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 lentivirus expression plasmids for stable overexpression of LDOC1
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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