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Aliases for LDLRAD4 Gene

Aliases for LDLRAD4 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 4 2 3
  • C18orf1 3 4 6
  • Clone 22 2 3
  • Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 4 3
  • Chromosome 18 Open Reading Frame 1 2

External Ids for LDLRAD4 Gene

Previous HGNC Symbols for LDLRAD4 Gene

  • C18orf1

Summaries for LDLRAD4 Gene

GeneCards Summary for LDLRAD4 Gene

LDLRAD4 (Low Density Lipoprotein Receptor Class A Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is PMEPA1.

UniProtKB/Swiss-Prot for LDLRAD4 Gene

  • Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDLRAD4 Gene

Genomics for LDLRAD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LDLRAD4 Gene

Start:
13,217,498 bp from pter
End:
13,652,755 bp from pter
Size:
435,258 bases
Orientation:
Plus strand

Genomic View for LDLRAD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LDLRAD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD4 Gene

No data available for Regulatory Elements for LDLRAD4 Gene

Proteins for LDLRAD4 Gene

  • Protein details for LDLRAD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15165-LRAD4_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 4
    Protein Accession:
    O15165
    Secondary Accessions:
    • B3KNT9
    • E9PAY9
    • K7EN38
    • O15166
    • O15167
    • O15168
    • Q5U646
    • Q6NXP3

    Protein attributes for LDLRAD4 Gene

    Size:
    306 amino acids
    Molecular mass:
    33900 Da
    Quaternary structure:
    • Interacts with PMEPA1. Interacts (via the SMAD interaction motif) with SMAD2 and SMAD3.

    Alternative splice isoforms for LDLRAD4 Gene

neXtProt entry for LDLRAD4 Gene

Proteomics data for LDLRAD4 Gene at MOPED

Post-translational modifications for LDLRAD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LDLRAD4 Gene

Domains for LDLRAD4 Gene

Protein Domains for LDLRAD4 Gene

Graphical View of Domain Structure for InterPro Entry

O15165

UniProtKB/Swiss-Prot:

LRAD4_HUMAN :
  • O15165
Domain:
  • The SMAD interaction motif is required for interaction with SMAD2 and SMAD3 and the negative regulation of TGF-beta signaling.
  • Contains 1 LDL-receptor class A domain.
Family:
  • Belongs to the PMEPA1 family.
genes like me logo Genes that share domains with LDLRAD4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for LDLRAD4 Gene

Function for LDLRAD4 Gene

Molecular function for LDLRAD4 Gene

UniProtKB/Swiss-Prot Function: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

Gene Ontology (GO) - Molecular Function for LDLRAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24627487
GO:0070412 R-SMAD binding IPI 24627487
genes like me logo Genes that share ontologies with LDLRAD4: view

Phenotypes for LDLRAD4 Gene

GenomeRNAi human phenotypes for LDLRAD4:
genes like me logo Genes that share phenotypes with LDLRAD4: view

Animal Model Products

CRISPR Products

miRNA for LDLRAD4 Gene

miRTarBase miRNAs that target LDLRAD4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LDLRAD4 Gene

Localization for LDLRAD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD4 Gene

Early endosome membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for LDLRAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0016021 integral component of membrane NAS 9479497
GO:0031901 early endosome membrane IEA --
genes like me logo Genes that share ontologies with LDLRAD4: view

No data available for Subcellular locations from COMPARTMENTS for LDLRAD4 Gene

Pathways for LDLRAD4 Gene

SuperPathways for LDLRAD4 Gene

No Data Available

Interacting Proteins for LDLRAD4 Gene

Gene Ontology (GO) - Biological Process for LDLRAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IMP 24627487
GO:0010991 negative regulation of SMAD protein complex assembly IDA 24627487
GO:0030336 negative regulation of cell migration IMP 24627487
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP 24627487
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IMP 24627487
genes like me logo Genes that share ontologies with LDLRAD4: view

No data available for Pathways by source for LDLRAD4 Gene

Transcripts for LDLRAD4 Gene

Unigene Clusters for LDLRAD4 Gene

Low density lipoprotein receptor class A domain containing 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LDLRAD4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LDLRAD4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - -
SP6:
SP7: - -
SP8:
SP9: -

Relevant External Links for LDLRAD4 Gene

GeneLoc Exon Structure for
LDLRAD4
ECgene alternative splicing isoforms for
LDLRAD4

Expression for LDLRAD4 Gene

mRNA expression in normal human tissues for LDLRAD4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LDLRAD4 Gene

SOURCE GeneReport for Unigene cluster for LDLRAD4 Gene Hs.731853

mRNA Expression by UniProt/SwissProt for LDLRAD4 Gene

O15165-LRAD4_HUMAN
Tissue specificity: Expressed in lymphocytes.
genes like me logo Genes that share expressions with LDLRAD4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LDLRAD4 Gene

Orthologs for LDLRAD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LDLRAD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDLRAD4 35
  • 99.46 (n)
  • 98.79 (a)
LDLRAD4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LDLRAD4 35
  • 82.18 (n)
  • 77.89 (a)
LDLRAD4 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LDLRAD4 35
  • 83.22 (n)
  • 81.25 (a)
LDLRAD4 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ldlrad4 35
  • 88.45 (n)
  • 90.2 (a)
Ldlrad4 16
Ldlrad4 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LDLRAD4 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LDLRAD4 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ldlrad4 35
  • 88.56 (n)
  • 90.52 (a)
chicken
(Gallus gallus)
Aves C2H18ORF1 35
  • 80.87 (n)
  • 87.44 (a)
LDLRAD4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LDLRAD4 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ldlrad4 35
  • 77.67 (n)
  • 83.33 (a)
zebrafish
(Danio rerio)
Actinopterygii ldlrad4 36
  • 65 (a)
OneToMany
LDLRAD4 (2 of 2) 36
  • 61 (a)
OneToMany
LOC556780 35
  • 70.33 (n)
  • 69.6 (a)
Species with no ortholog for LDLRAD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LDLRAD4 Gene

ENSEMBL:
Gene Tree for LDLRAD4 (if available)
TreeFam:
Gene Tree for LDLRAD4 (if available)

Paralogs for LDLRAD4 Gene

Paralogs for LDLRAD4 Gene

Selected SIMAP similar genes for LDLRAD4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LDLRAD4: view

Variants for LDLRAD4 Gene

Sequence variations from dbSNP and Humsavar for LDLRAD4 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1225 -- 13,337,560(+) ACTTG(A/T)TCAGT intron-variant, upstream-variant-2KB
rs9892 -- 13,652,242(+) TTAAA(A/C/T)TTTAC utr-variant-3-prime
rs13081 -- 13,651,138(+) CATCA(A/C/T)GAAGG utr-variant-3-prime
rs472575 -- 13,337,717(+) atagc(A/C)aaaac intron-variant, upstream-variant-2KB
rs485120 -- 13,299,783(+) gctgc(A/C)gtgag intron-variant

Relevant External Links for LDLRAD4 Gene

HapMap Linkage Disequilibrium report
LDLRAD4
Human Gene Mutation Database (HGMD)
LDLRAD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LDLRAD4 Gene

Disorders for LDLRAD4 Gene

No disorders were found for LDLRAD4 Gene.

No data available for UniProtKB/Swiss-Prot for LDLRAD4 Gene

Publications for LDLRAD4 Gene

  1. Multiple transcriptional variants and RNA editing in C18orf1, a novel gene with LDLRA and transmembrane domains on 18p11.2. (PMID: 9479497) Yoshikawa T. … Detera-Wadleigh S.D. (Genomics 1998) 2 3 4
  2. C18 ORF1, a novel negative regulator of transforming growth factor- beta signaling. (PMID: 24627487) Nakano N. … Itoh S. (J. Biol. Chem. 2014) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Isolation of chromosome 18-specific brain transcripts as positional candidates for bipolar disorder. (PMID: 9129712) Yoshikawa T. … Detera-Wadleigh S.D. (Am. J. Med. Genet. 1997) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for LDLRAD4 Gene

Sources for LDLRAD4 Gene

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