LDLRAD3 Gene
protein-coding GIFtS: 41
GCID: GC11P035923
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low density lipoprotein receptor class A domain containing...
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Aliases
for LDLRAD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Low Density Lipoprotein Receptor Class A Domain Containing 31 2 | | LRAD32 | | Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 32 |
Export aliases for LDLRAD3 gene to outside databasesPrevious GC identifer: GC11P035664 |
Summaries
for LDLRAD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LRAD3_HUMAN, Q86YD5Function: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3peptide production (By similarity)
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Genomic Views
for LDLRAD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LDLRAD3 gene promoter:
ATF-2 Pax-6 CUTL1 Evi-1 HNF-1A GATA-1 IRF-2 HNF-1 FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LDLRAD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDLRAD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13LDLRAD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P035923: view genomic region
(about GC identifiers)
Start:
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35,965,531 bp from pter |
End:
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36,253,686 bp from pter |
Size:
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288,156 bases |
Orientation:
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plus strand |
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Proteins
for LDLRAD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRAD3_HUMAN, Q86YD5 (See
protein sequence)Recommended Name: Low-density lipoprotein receptor class A domain-containing protein 3 precursor Size: 345 amino acids; 37419 Da
Subunit: Interacts with APP precursor C-terminus (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: B9EG81 Q8NBJ0Explore the universe of human proteins at neXtProt for LDLRAD3: NX_Q86YD5
LDLRAD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_777562.1
ENSEMBL proteins: ENSP00000433954 ENSP00000434313 ENSP00000318607
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
LDLRAD3 for ontologies About GeneDecksing
LDLRAD3 Antibody Products:
Assay Products for LDLRAD3: |
Protein
Domains /
Families
for LDLRAD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LDLRAD3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86YD5ProtoNet protein and cluster: Q86YD5 1 Blocks protein family: IPB002172 Low density lipoprotein-receptor
UniProtKB/Swiss-Prot: LRAD3_HUMAN, Q86YD5Similarity: Belongs to the LDLR familySimilarity: Contains 3 LDL-receptor class A domains |
Function
for LDLRAD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LRAD3_HUMAN, Q86YD5Function: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3peptide production (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LDLRAD3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LDLRAD3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LDLRAD3 (NM_174902) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LDLRAD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDLRAD3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDLRAD3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001540 | beta-amyloid binding |
IEA | -- | | GO:0004872 | receptor activity |
-- | -- |
LDLRAD3 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Ldlrad3 (no phenotypes)
LDLRAD3 for phenotypes About GeneDecksing
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Pathways & Interactions
for LDLRAD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LDLRAD3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for LDLRAD3 (ENSP000003186074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006898 | receptor-mediated endocytosis |
IEA | -- | | GO:0070613 | regulation of protein processing |
IEA | -- |
LDLRAD3 for ontologies About GeneDecksing
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Drugs & Compounds
for LDLRAD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LDLRAD3
Search CenterWatch for drugs/clinical trials and news about LDLRAD3 / LRAD3
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Transcripts
for LDLRAD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LDLRAD3 gene: NM_174902.2 Unigene Cluster for LDLRAD3: Low density lipoprotein receptor class A domain containing 3 Hs.636203 [show with all ESTs]Unigene Representative Sequence: BC0427546 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528989 ENST00000524419 ENST00000315571(uc001mwk.1 uc010rey.1 uc010rez.1 uc010rfa.1)
ENST00000532490 ENST00000534091 ENST00000529759
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LDLRAD3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LDLRAD3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LDLRAD3 (NM_174902) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LDLRAD3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDLRAD3 |
Additional cDNA sequence: AK075546.1 AK293930.1 AK299186.1 BC042754.1 BC136286.1 BC143823.1 BC143824.1 8 DOTS entries: DT.102821304 DT.406497 DT.95268788 DT.100781962 DT.120719946 DT.120719976 DT.95148028 DT.120719880 24/69 AceView cDNA sequences (see all 69): AA302738 BX283894 AK075546 AA380138 BG830323 BQ435209 CB045639 NM_174902 CB144599 BU732126 BU101955 BU633144 AI553724 CD515264 AI816007 BX477884 BQ438101 AA383623 BI966173 BG721775 BI222970 BM927230 CK904050 BM802107
GeneLoc Exon Structure
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Expression
for LDLRAD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LDLRAD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCAAGAGAC
About this image
See LDLRAD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LDLRAD3
SOURCE GeneReport for Unigene cluster: Hs.636203
UniProtKB/Swiss-Prot: LRAD3_HUMAN, Q86YD5Tissue specificity: Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderatelevels in heart, placenta, and kidney but not detected in the liver
SABiosciences Custom PCR Arrays for LDLRAD3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LDLRAD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LDLRAD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDLRAD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDLRAD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDLRAD3 |
Orthologs
for LDLRAD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for LDLRAD3 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for LDLRAD3 (if available)
TreeFam Gene Tree for LDLRAD3 (if available) |
Paralogs
for LDLRAD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LDLRAD3 gene
- LRP122 CD3202 LRP32 LRP102
18/36 SIMAP similar genes for LDLRAD3 using alignment to 3 protein entries: LRAD3_HUMAN (see all proteins)
(see all similar genes):HC6 SEPSECS DYNC2LI1 CASC4 KIAA1651 ARL6IP5
C14orf105 RHBG pp12301 IK C12orf76 ADCK1
RAD51 LOC100996300 NLN SNRPF COQ5 GEMIN6
LDLRAD3 for paralogs About GeneDecksing
|
Genomic Variants
for LDLRAD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LDLRAD3 (35965531 - 36215531 bp, first 250kb of LDLRAD3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for LDLRAD3
1 CNV: 5274
2 Indels: 48795 101182 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LDLRAD3 |
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Disorders
/ Diseases
for LDLRAD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 LDLRAD3 for disorders About MalaCards
LDLRAD3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: LDLRAD3 (2 documents)
Export disorders for LDLRAD3 gene to outside databases
|
Publications
for LDLRAD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LDLRAD3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LDLRAD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. (PubMed id 21795536)1, 2 Ranganathan S.... Strickland D.K. (2011)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Analysis of 9p24 and 11p12-13 regions in autism spect rum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. (PubMed id 20410850)1 KantojAorvi K....JAorvelAo I. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for LDLRAD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing LDLRAD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LDLRAD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LDLRAD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LDLRAD3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for LDLRAD3 gene:
Search GeneIP for patents involving LDLRAD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LDLRAD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LDLRAD3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LDLRAD3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LDLRAD3 | | | OriGene Protein Over-expression Lysate for LDLRAD3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LDLRAD3 | | OriGene 3'-UTR Clone for LDLRAD3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LDLRAD3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LDLRAD3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LDLRAD3 | | OriGene Custom Protein Services for LDLRAD3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LDLRAD3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LDLRAD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDLRAD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LDLRAD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDLRAD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDLRAD3 |
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| | | | Search Tocris compounds for LDLRAD3 |
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 | | | LDLRAD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDLRAD3 |
|  |  |  | | | | Search ThermoFisher Antibodies for LDLRAD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDLRAD3 |
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