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Aliases for LDLRAD3 Gene

Aliases for LDLRAD3 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 3 2 3
  • Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3 3
  • LRAD3 3

External Ids for LDLRAD3 Gene

Previous GeneCards Identifiers for LDLRAD3 Gene

  • GC11P035664

Summaries for LDLRAD3 Gene

GeneCards Summary for LDLRAD3 Gene

LDLRAD3 (Low Density Lipoprotein Receptor Class A Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include beta-amyloid binding. An important paralog of this gene is LRP10.

UniProtKB/Swiss-Prot for LDLRAD3 Gene

  • May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDLRAD3 Gene

Genomics for LDLRAD3 Gene

Regulatory Elements for LDLRAD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LDLRAD3 Gene

Start:
35,943,981 bp from pter
End:
36,232,136 bp from pter
Size:
288,156 bases
Orientation:
Plus strand

Genomic View for LDLRAD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LDLRAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD3 Gene

Proteins for LDLRAD3 Gene

  • Protein details for LDLRAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YD5-LRAD3_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 3
    Protein Accession:
    Q86YD5
    Secondary Accessions:
    • B7Z1U3
    • B9EG81
    • Q8NBJ0

    Protein attributes for LDLRAD3 Gene

    Size:
    345 amino acids
    Molecular mass:
    37419 Da
    Quaternary structure:
    • Interacts with APP precursor C-terminus.

    Alternative splice isoforms for LDLRAD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LDLRAD3 Gene

Proteomics data for LDLRAD3 Gene at MOPED

Post-translational modifications for LDLRAD3 Gene

Other Protein References for LDLRAD3 Gene

No data available for DME Specific Peptides for LDLRAD3 Gene

Domains for LDLRAD3 Gene

Protein Domains for LDLRAD3 Gene

Suggested Antigen Peptide Sequences for LDLRAD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YD5

UniProtKB/Swiss-Prot:

LRAD3_HUMAN :
  • Q86YD5
Domain:
  • Contains 3 LDL-receptor class A domains.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD3: view

No data available for Gene Families for LDLRAD3 Gene

Function for LDLRAD3 Gene

Molecular function for LDLRAD3 Gene

UniProtKB/Swiss-Prot Function: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.

Gene Ontology (GO) - Molecular Function for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LDLRAD3: view

Animal Model Products

CRISPR Products

miRNA for LDLRAD3 Gene

miRTarBase miRNAs that target LDLRAD3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LDLRAD3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LDLRAD3 Gene

Localization for LDLRAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDLRAD3 Gene COMPARTMENTS Subcellular localization image for LDLRAD3 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with LDLRAD3: view

Pathways for LDLRAD3 Gene

SuperPathways for LDLRAD3 Gene

No Data Available

Interacting Proteins for LDLRAD3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000318607%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000318607 for LDLRAD3 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0070613 regulation of protein processing IEA --
genes like me logo Genes that share ontologies with LDLRAD3: view

No data available for Pathways by source for LDLRAD3 Gene

Transcripts for LDLRAD3 Gene

Unigene Clusters for LDLRAD3 Gene

Low density lipoprotein receptor class A domain containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LDLRAD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LDLRAD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD3 Gene

No ASD Table

Relevant External Links for LDLRAD3 Gene

GeneLoc Exon Structure for
LDLRAD3
ECgene alternative splicing isoforms for
LDLRAD3

Expression for LDLRAD3 Gene

mRNA expression in normal human tissues for LDLRAD3 Gene

SOURCE GeneReport for Unigene cluster for LDLRAD3 Gene Hs.745134

mRNA Expression by UniProt/SwissProt for LDLRAD3 Gene

Q86YD5-LRAD3_HUMAN
Tissue specificity: Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver.
genes like me logo Genes that share expressions with LDLRAD3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for LDLRAD3 Gene

Orthologs for LDLRAD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LDLRAD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDLRAD3 35
  • 99.32 (n)
  • 100 (a)
LDLRAD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LDLRAD3 35
  • 92.37 (n)
  • 97.97 (a)
LDLRAD3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LDLRAD3 35
  • 89.06 (n)
  • 93.5 (a)
LDLRAD3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ldlrad3 35
  • 89.57 (n)
  • 95.94 (a)
Ldlrad3 16
Ldlrad3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LDLRAD3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LDLRAD3 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ldlrad3 35
  • 88.5 (n)
  • 96.23 (a)
chicken
(Gallus gallus)
Aves LDLRAD3 35
  • 80.71 (n)
  • 87.86 (a)
LDLRAD3 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LDLRAD3 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ldlrad3 35
  • 73.25 (n)
  • 76.43 (a)
Str.3049 35
zebrafish
(Danio rerio)
Actinopterygii ldlrad3 35
  • 65.08 (n)
  • 58.73 (a)
ldlrad3 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta modSP 36
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03E7.4 36
  • 12 (a)
OneToMany
Species with no ortholog for LDLRAD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LDLRAD3 Gene

ENSEMBL:
Gene Tree for LDLRAD3 (if available)
TreeFam:
Gene Tree for LDLRAD3 (if available)

Paralogs for LDLRAD3 Gene

Paralogs for LDLRAD3 Gene

genes like me logo Genes that share paralogs with LDLRAD3: view

Variants for LDLRAD3 Gene

Sequence variations from dbSNP and Humsavar for LDLRAD3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs262401 -- 36,012,491(-) gaaga(A/G)tgatg intron-variant
rs262402 -- 36,012,195(-) aggtt(C/T)cagtt intron-variant
rs262403 -- 36,011,979(-) ACCGT(A/G)CCTGC intron-variant
rs262407 -- 36,007,825(-) AGCCT(A/G)TCGGA intron-variant
rs262408 -- 36,007,012(+) CCCCA(A/G)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LDLRAD3 Gene

Variant ID Type Subtype PubMed ID
nsv832122 CNV Gain 17160897
esv2422305 CNV Duplication 17116639
esv271874 CNV Insertion 20981092
nsv7735 CNV Insertion 18451855
nsv897224 CNV Gain 21882294
esv1294533 CNV Insertion 17803354
esv2548850 CNV Insertion 19546169
nsv513311 CNV Insertion 21212237
nsv467791 CNV Gain 19166990
esv2744345 CNV Deletion 23290073
nsv516850 CNV Loss 19592680
nsv897225 CNV Gain 21882294
nsv897226 CNV Loss 21882294
esv1443244 CNV Deletion 17803354
esv269629 CNV Insertion 20981092
esv2670859 CNV Deletion 23128226

Relevant External Links for LDLRAD3 Gene

HapMap Linkage Disequilibrium report
LDLRAD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDLRAD3 Gene

Disorders for LDLRAD3 Gene

Relevant External Links for LDLRAD3

Genetic Association Database (GAD)
LDLRAD3
Human Genome Epidemiology (HuGE) Navigator
LDLRAD3
genes like me logo Genes that share disorders with LDLRAD3: view

No data available for UniProtKB/Swiss-Prot for LDLRAD3 Gene

Publications for LDLRAD3 Gene

  1. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. (PMID: 21795536) Ranganathan S. … Strickland D.K. (J. Neurosci. 2011) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. (PMID: 20410850) KantojAorvi K. … JAorvelAo I. (Psychiatr. Genet. 2010) 3 48
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for LDLRAD3 Gene

Sources for LDLRAD3 Gene

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