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Aliases for LDLRAD3 Gene

Aliases for LDLRAD3 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 3 2 3 5
  • Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3 3
  • LRAD3 3

External Ids for LDLRAD3 Gene

Previous GeneCards Identifiers for LDLRAD3 Gene

  • GC11P035664

Summaries for LDLRAD3 Gene

GeneCards Summary for LDLRAD3 Gene

LDLRAD3 (Low Density Lipoprotein Receptor Class A Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include beta-amyloid binding. An important paralog of this gene is LRP10.

UniProtKB/Swiss-Prot for LDLRAD3 Gene

  • May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDLRAD3 Gene

Genomics for LDLRAD3 Gene

Regulatory Elements for LDLRAD3 Gene

Enhancers for LDLRAD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F035969 1.2 Ensembl ENCODE 11 +25.5 25531 0.8 ZFP69B SMARCA4 ZNF692 POLR2A JUNB ENSG00000254919 LDLRAD3 ENSG00000255256 LOC100420018
GH11F035974 0.7 ENCODE 11 +31.2 31238 1.4 LDLRAD3 ENSG00000255256 GC11M035997
GH11F036008 0.9 Ensembl ENCODE 10.9 +65.2 65197 3.3 JUN CEBPG RAD21 RFX5 GATA3 FOS MAFK MAFG CEBPB DPF2 LDLRAD3 CD44 MIR3973 RPL12P31
GH11F036007 0.7 ENCODE 10.9 +63.5 63528 0.0 ZNF217 GATA3 DPF2 SP7 LDLRAD3 MIR3973 RPL12P31
GH11F035907 1 Ensembl ENCODE 10.7 -35.4 -35392 1.8 RFX5 GTF3C2 POLR3A ETV6 FOS CREM DEK ZNF680 CEBPB JUNB LDLRAD3 ENSG00000254919 KRT18P14
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LDLRAD3 on UCSC Golden Path with GeneCards custom track

Promoters for LDLRAD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000561248 120 1800 ZNF76 KLF17 SIN3A DNMT3B ZNF2 GLIS2 EGR1 SCRT2 KLF7 EGR2

Genomic Location for LDLRAD3 Gene

Chromosome:
11
Start:
35,943,981 bp from pter
End:
36,232,136 bp from pter
Size:
288,156 bases
Orientation:
Plus strand

Genomic View for LDLRAD3 Gene

Genes around LDLRAD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDLRAD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDLRAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD3 Gene

Proteins for LDLRAD3 Gene

  • Protein details for LDLRAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YD5-LRAD3_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 3
    Protein Accession:
    Q86YD5
    Secondary Accessions:
    • B7Z1U3
    • B9EG81
    • Q8NBJ0

    Protein attributes for LDLRAD3 Gene

    Size:
    345 amino acids
    Molecular mass:
    37419 Da
    Quaternary structure:
    • Interacts with APP precursor C-terminus.

    Alternative splice isoforms for LDLRAD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LDLRAD3 Gene

Post-translational modifications for LDLRAD3 Gene

Other Protein References for LDLRAD3 Gene

No data available for DME Specific Peptides for LDLRAD3 Gene

Domains & Families for LDLRAD3 Gene

Protein Domains for LDLRAD3 Gene

Suggested Antigen Peptide Sequences for LDLRAD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YD5

UniProtKB/Swiss-Prot:

LRAD3_HUMAN :
  • Contains 3 LDL-receptor class A domains.
  • Belongs to the LDLR family.
Domain:
  • Contains 3 LDL-receptor class A domains.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD3: view

No data available for Gene Families for LDLRAD3 Gene

Function for LDLRAD3 Gene

Molecular function for LDLRAD3 Gene

UniProtKB/Swiss-Prot Function:
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.

Gene Ontology (GO) - Molecular Function for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IEA --
genes like me logo Genes that share ontologies with LDLRAD3: view
genes like me logo Genes that share phenotypes with LDLRAD3: view

Animal Model Products

miRNA for LDLRAD3 Gene

miRTarBase miRNAs that target LDLRAD3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDLRAD3 Gene

Localization for LDLRAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDLRAD3 Gene COMPARTMENTS Subcellular localization image for LDLRAD3 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with LDLRAD3: view

Pathways & Interactions for LDLRAD3 Gene

SuperPathways for LDLRAD3 Gene

No Data Available

Interacting Proteins for LDLRAD3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000318607%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000318607 Q86YD5-LRAD3_HUMAN for LDLRAD3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for LDLRAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0070613 regulation of protein processing IEA --
genes like me logo Genes that share ontologies with LDLRAD3: view

No data available for Pathways by source and SIGNOR curated interactions for LDLRAD3 Gene

Transcripts for LDLRAD3 Gene

Unigene Clusters for LDLRAD3 Gene

Low density lipoprotein receptor class A domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD3 Gene

No ASD Table

Relevant External Links for LDLRAD3 Gene

GeneLoc Exon Structure for
LDLRAD3
ECgene alternative splicing isoforms for
LDLRAD3

Expression for LDLRAD3 Gene

mRNA expression in normal human tissues for LDLRAD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of LDLRAD3 Gene:

LDLRAD3

SOURCE GeneReport for Unigene cluster for LDLRAD3 Gene:

Hs.745134

mRNA Expression by UniProt/SwissProt for LDLRAD3 Gene:

Q86YD5-LRAD3_HUMAN
Tissue specificity: Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver.
genes like me logo Genes that share expression patterns with LDLRAD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LDLRAD3 Gene

Orthologs for LDLRAD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LDLRAD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDLRAD3 34 35
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia LDLRAD3 34 35
  • 92.37 (n)
mouse
(Mus musculus)
Mammalia Ldlrad3 34 16 35
  • 89.57 (n)
dog
(Canis familiaris)
Mammalia LDLRAD3 34 35
  • 89.06 (n)
rat
(Rattus norvegicus)
Mammalia Ldlrad3 34
  • 88.5 (n)
oppossum
(Monodelphis domestica)
Mammalia LDLRAD3 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LDLRAD3 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LDLRAD3 34 35
  • 80.71 (n)
lizard
(Anolis carolinensis)
Reptilia LDLRAD3 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ldlrad3 34
  • 73.25 (n)
Str.3049 34
zebrafish
(Danio rerio)
Actinopterygii ldlrad3 34 35
  • 65.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta modSP 35
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03E7.4 35
  • 12 (a)
OneToMany
Species where no ortholog for LDLRAD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LDLRAD3 Gene

ENSEMBL:
Gene Tree for LDLRAD3 (if available)
TreeFam:
Gene Tree for LDLRAD3 (if available)

Paralogs for LDLRAD3 Gene

Variants for LDLRAD3 Gene

Sequence variations from dbSNP and Humsavar for LDLRAD3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001715 -- 36,109,422(-) CTTGG(C/T)GATTC intron-variant
rs10082606 -- 36,206,870(+) acagg(C/T)gcccc intron-variant
rs10082626 -- 36,209,149(+) ttaaa(G/T)tcatg intron-variant
rs10082659 -- 36,122,428(+) AACAG(G/T)ATTCA intron-variant
rs10082681 -- 36,121,126(+) CTCAA(C/T)AACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LDLRAD3 Gene

Variant ID Type Subtype PubMed ID
dgv190e214 CNV loss 21293372
esv1294533 CNV insertion 17803354
esv1443244 CNV deletion 17803354
esv2422305 CNV duplication 17116639
esv2548850 CNV insertion 19546169
esv2670859 CNV deletion 23128226
esv2744345 CNV deletion 23290073
esv3305351 CNV mobile element insertion 20981092
esv3307600 CNV mobile element insertion 20981092
esv3373596 CNV insertion 20981092
esv3406327 CNV insertion 20981092
esv3579475 CNV loss 25503493
esv3625942 CNV loss 21293372
esv3625947 CNV loss 21293372
esv3625948 CNV loss 21293372
esv3625950 CNV loss 21293372
esv3891964 CNV loss 25118596
nsv1042014 CNV loss 25217958
nsv1070950 CNV deletion 25765185
nsv467791 CNV gain 19166990
nsv513311 CNV insertion 21212237
nsv516850 CNV loss 19592680
nsv554002 CNV loss 21841781
nsv554003 CNV gain 21841781
nsv7735 CNV insertion 18451855
nsv832122 CNV gain 17160897
nsv983002 CNV duplication 23825009

Variation tolerance for LDLRAD3 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDLRAD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDLRAD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDLRAD3 Gene

Disorders for LDLRAD3 Gene

Relevant External Links for LDLRAD3

Genetic Association Database (GAD)
LDLRAD3
Human Genome Epidemiology (HuGE) Navigator
LDLRAD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDLRAD3

No disorders were found for LDLRAD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDLRAD3 Gene

Publications for LDLRAD3 Gene

  1. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. (PMID: 21795536) Ranganathan S. … Strickland D.K. (J. Neurosci. 2011) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. (PMID: 20410850) KantojAorvi K. … JAorvelAo I. (Psychiatr. Genet. 2010) 3 46 64
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  5. Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. (PMID: 26854353) Noyes N.C. … Strickland D.K. (Biochemistry 2016) 3 64

Products for LDLRAD3 Gene

Sources for LDLRAD3 Gene

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