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Aliases for LDLRAD2 Gene

Aliases for LDLRAD2 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 2 2 3
  • Low Density Lipoprotein Receptor A Domain Containing 2 2

External Ids for LDLRAD2 Gene

Previous GeneCards Identifiers for LDLRAD2 Gene

  • GC01P021885
  • GC01P022011
  • GC01P022138
  • GC01P020382

Summaries for LDLRAD2 Gene

GeneCards Summary for LDLRAD2 Gene

LDLRAD2 (Low Density Lipoprotein Receptor Class A Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDLRAD2 Gene

Genomics for LDLRAD2 Gene

Regulatory Elements for LDLRAD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LDLRAD2 Gene

Chromosome:
1
Start:
21,812,265 bp from pter
End:
21,825,221 bp from pter
Size:
12,957 bases
Orientation:
Plus strand

Genomic View for LDLRAD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LDLRAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD2 Gene

Proteins for LDLRAD2 Gene

  • Protein details for LDLRAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SZI1-LRAD2_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 2
    Protein Accession:
    Q5SZI1
    Secondary Accessions:
    • B9EJB3
    • Q6ZSN5

    Protein attributes for LDLRAD2 Gene

    Size:
    272 amino acids
    Molecular mass:
    28581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDLRAD2 Gene

Proteomics data for LDLRAD2 Gene at MOPED

Post-translational modifications for LDLRAD2 Gene

  • Glycosylation at Asn 97
  • Modification sites at PhosphoSitePlus

Other Protein References for LDLRAD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LDLRAD2 Gene

Domains & Families for LDLRAD2 Gene

Protein Domains for LDLRAD2 Gene

Suggested Antigen Peptide Sequences for LDLRAD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5SZI1

UniProtKB/Swiss-Prot:

LRAD2_HUMAN :
  • Contains 1 LDL-receptor class A domain.
  • Belongs to the LDLR family.
Domain:
  • Contains 1 LDL-receptor class A domain.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD2: view

No data available for Gene Families for LDLRAD2 Gene

Function for LDLRAD2 Gene

Gene Ontology (GO) - Molecular Function for LDLRAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LDLRAD2: view

Phenotypes for LDLRAD2 Gene

GenomeRNAi human phenotypes for LDLRAD2:
genes like me logo Genes that share phenotypes with LDLRAD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LDLRAD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LDLRAD2 Gene

Localization for LDLRAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD2 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for LDLRAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LDLRAD2: view

No data available for Subcellular locations from COMPARTMENTS for LDLRAD2 Gene

Pathways & Interactions for LDLRAD2 Gene

SuperPathways for LDLRAD2 Gene

No Data Available

Interacting Proteins for LDLRAD2 Gene

Gene Ontology (GO) - Biological Process for LDLRAD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LDLRAD2 Gene

Drugs & Compounds for LDLRAD2 Gene

No Compound Related Data Available

Transcripts for LDLRAD2 Gene

mRNA/cDNA for LDLRAD2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDLRAD2 Gene

Low density lipoprotein receptor class A domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LDLRAD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD2 Gene

No ASD Table

Relevant External Links for LDLRAD2 Gene

GeneLoc Exon Structure for
LDLRAD2
ECgene alternative splicing isoforms for
LDLRAD2

Expression for LDLRAD2 Gene

mRNA expression in normal human tissues for LDLRAD2 Gene

mRNA differential expression in normal tissues according to GTEx for LDLRAD2 Gene

This gene is overexpressed in Artery - Tibial (x5.8) and Artery - Aorta (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LDLRAD2 Gene



SOURCE GeneReport for Unigene cluster for LDLRAD2 Gene Hs.745158

genes like me logo Genes that share expression patterns with LDLRAD2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LDLRAD2 Gene

Orthologs for LDLRAD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LDLRAD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LDLRAD2 35
  • 83.2 (n)
  • 76.02 (a)
LDLRAD2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LDLRAD2 35
  • 80.73 (n)
  • 73.84 (a)
LDLRAD2 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ldlrad2 35
  • 67.16 (n)
  • 53.73 (a)
Ldlrad2 16
chimpanzee
(Pan troglodytes)
Mammalia LDLRAD2 35
  • 98.9 (n)
  • 97.43 (a)
LDLRAD2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ldlrad2 35
  • 75.11 (n)
  • 69.1 (a)
oppossum
(Monodelphis domestica)
Mammalia LDLRAD2 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ldlrad2 36
  • 32 (a)
OneToOne
Species with no ortholog for LDLRAD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LDLRAD2 Gene

ENSEMBL:
Gene Tree for LDLRAD2 (if available)
TreeFam:
Gene Tree for LDLRAD2 (if available)

Paralogs for LDLRAD2 Gene

No data available for Paralogs for LDLRAD2 Gene

Variants for LDLRAD2 Gene

Sequence variations from dbSNP and Humsavar for LDLRAD2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2010397 -- 21,815,490(-) GGGCG(A/G)GTATT intron-variant
rs4654769 -- 21,820,542(+) AAAAA(A/G)AAAAG intron-variant
rs4654770 -- 21,820,584(+) CATGC(A/G)TAATT intron-variant
rs4654986 -- 21,811,705(+) CCAGT(A/G)GACAA upstream-variant-2KB
rs6656070 -- 21,811,974(+) TAATA(C/G)AGCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LDLRAD2 Gene

Variant ID Type Subtype PubMed ID
esv34155 CNV Loss 18971310
nsv871274 CNV Loss 21882294
nsv515659 CNV Loss 19592680
nsv509013 CNV Insertion 20534489
dgv193n71 CNV Loss 21882294
dgv194n71 CNV Loss 21882294
nsv834402 CNV Loss 17160897
esv33407 CNV Gain 17666407
nsv460762 CNV Loss 19166990
nsv870552 CNV Loss 21882294
nsv469549 CNV Loss 16826518
esv2745086 CNV Deletion 23290073
esv2664487 CNV Deletion 23128226
esv1196174 CNV Deletion 17803354
nsv470706 CNV Loss 18288195

Variation tolerance for LDLRAD2 Gene

Residual Variation Intolerance Score: 59.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDLRAD2 Gene

HapMap Linkage Disequilibrium report
LDLRAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDLRAD2 Gene

Disorders for LDLRAD2 Gene

Relevant External Links for LDLRAD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDLRAD2
genes like me logo Genes that share disorders with LDLRAD2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDLRAD2 Gene

Publications for LDLRAD2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for LDLRAD2 Gene

Sources for LDLRAD2 Gene

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