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Aliases for LDLRAD2 Gene

Aliases for LDLRAD2 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 2 2 3 5
  • Low Density Lipoprotein Receptor A Domain Containing 2 2

External Ids for LDLRAD2 Gene

Previous GeneCards Identifiers for LDLRAD2 Gene

  • GC01P021885
  • GC01P022011
  • GC01P022138
  • GC01P020382

Summaries for LDLRAD2 Gene

GeneCards Summary for LDLRAD2 Gene

LDLRAD2 (Low Density Lipoprotein Receptor Class A Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDLRAD2 Gene

Genomics for LDLRAD2 Gene

Regulatory Elements for LDLRAD2 Gene

Enhancers for LDLRAD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G021893 2 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +93.0 93030 22.6 HNRNPUL1 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ZFP64 SIN3A YBX1 CDC42-IT1 ENSG00000271428 HSPG2 LDLRAD2 ZBTB40-IT1 EPHB2 RPL21P29 GC01M021883
GH01G022047 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +236.4 236384 1.5 HDGF ATF1 CREB3L1 ARID4B YBX1 ZNF48 FOS KDM4B JUNB MXD4 LINC00339 LDLRAD2 CDC42 GC01M022038
GH01G021791 1.3 ENCODE dbSUPER 13.1 -20.4 -20432 1.2 HDGF PKNOX1 CREB3L1 ARNT ZNF766 CBX5 ZNF143 ZNF207 KLF13 ZNF263 USP48 LDLRAD2 GC01P021790
GH01G021884 0.7 dbSUPER 22.5 +74.0 73997 3.1 YBX3 CTCF HDGF NR2F1 ZBTB7A ZKSCAN1 ZNF592 CREB3 ZNF121 CBX8 LDLRAD2 HSPG2 USP48 LINC00339 GC01M021883 RPL21P29
GH01G021301 1.4 Ensembl ENCODE dbSUPER 10.1 -508.9 -508897 3.0 ELF3 YBX3 SIN3A KLF17 RAD21 ZNF121 GLIS2 ZSCAN5C FOS SMARCA5 LDLRAD2 NBPF3 LOC100506801 ECE1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LDLRAD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LDLRAD2 Gene

Chromosome:
1
Start:
21,812,265 bp from pter
End:
21,825,221 bp from pter
Size:
12,957 bases
Orientation:
Plus strand

Genomic View for LDLRAD2 Gene

Genes around LDLRAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDLRAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDLRAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD2 Gene

Proteins for LDLRAD2 Gene

  • Protein details for LDLRAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SZI1-LRAD2_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 2
    Protein Accession:
    Q5SZI1
    Secondary Accessions:
    • B9EJB3
    • Q6ZSN5

    Protein attributes for LDLRAD2 Gene

    Size:
    272 amino acids
    Molecular mass:
    28581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDLRAD2 Gene

Post-translational modifications for LDLRAD2 Gene

  • Glycosylation at posLast=9797
  • Modification sites at PhosphoSitePlus

Other Protein References for LDLRAD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LDLRAD2 Gene

Domains & Families for LDLRAD2 Gene

Protein Domains for LDLRAD2 Gene

Suggested Antigen Peptide Sequences for LDLRAD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5SZI1

UniProtKB/Swiss-Prot:

LRAD2_HUMAN :
  • Belongs to the LDLR family.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD2: view

No data available for Gene Families for LDLRAD2 Gene

Function for LDLRAD2 Gene

Phenotypes for LDLRAD2 Gene

GenomeRNAi human phenotypes for LDLRAD2:
genes like me logo Genes that share phenotypes with LDLRAD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDLRAD2 Gene

Localization for LDLRAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDLRAD2 gene
Compartment Confidence
extracellular 3
plasma membrane 2
peroxisome 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LDLRAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LDLRAD2: view

Pathways & Interactions for LDLRAD2 Gene

SuperPathways for LDLRAD2 Gene

No Data Available

Interacting Proteins for LDLRAD2 Gene

Gene Ontology (GO) - Biological Process for LDLRAD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LDLRAD2 Gene

Drugs & Compounds for LDLRAD2 Gene

No Compound Related Data Available

Transcripts for LDLRAD2 Gene

mRNA/cDNA for LDLRAD2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDLRAD2 Gene

Low density lipoprotein receptor class A domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD2 Gene

No ASD Table

Relevant External Links for LDLRAD2 Gene

GeneLoc Exon Structure for
LDLRAD2
ECgene alternative splicing isoforms for
LDLRAD2

Expression for LDLRAD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LDLRAD2 Gene

mRNA differential expression in normal tissues according to GTEx for LDLRAD2 Gene

This gene is overexpressed in Artery - Tibial (x5.8) and Artery - Aorta (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LDLRAD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of LDLRAD2 Gene:

LDLRAD2

SOURCE GeneReport for Unigene cluster for LDLRAD2 Gene:

Hs.745158

Evidence on tissue expression from TISSUES for LDLRAD2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LDLRAD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDLRAD2 Gene

Orthologs for LDLRAD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LDLRAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDLRAD2 34 35
  • 98.9 (n)
cow
(Bos Taurus)
Mammalia LDLRAD2 34 35
  • 83.2 (n)
dog
(Canis familiaris)
Mammalia LDLRAD2 34 35
  • 80.73 (n)
rat
(Rattus norvegicus)
Mammalia Ldlrad2 34
  • 75.11 (n)
mouse
(Mus musculus)
Mammalia Ldlrad2 34 16
  • 67.16 (n)
oppossum
(Monodelphis domestica)
Mammalia LDLRAD2 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ldlrad2 35
  • 32 (a)
OneToOne
Species where no ortholog for LDLRAD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LDLRAD2 Gene

ENSEMBL:
Gene Tree for LDLRAD2 (if available)
TreeFam:
Gene Tree for LDLRAD2 (if available)

Paralogs for LDLRAD2 Gene

No data available for Paralogs for LDLRAD2 Gene

Variants for LDLRAD2 Gene

Sequence variations from dbSNP and Humsavar for LDLRAD2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1049675 Likely benign 21,822,324(-) TGGGA(C/T)GCCTG utr-variant-3-prime
rs1138469 Likely benign 21,823,625(-) GCAGC(A/G)TCTAC reference, missense, utr-variant-3-prime
rs117182812 Likely benign 21,824,302(+) AGGAC(C/T)TACCT intron-variant, utr-variant-3-prime
rs151184052 Likely benign 21,824,178(+) CCAGG(C/T)GGGCC reference, missense, utr-variant-3-prime
rs2229477 Likely benign 21,823,373(-) CAGCC(C/T)CTGGA reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LDLRAD2 Gene

Variant ID Type Subtype PubMed ID
dgv180n54 CNV loss 21841781
esv1196174 CNV deletion 17803354
esv2664487 CNV deletion 23128226
esv2745086 CNV deletion 23290073
esv33407 CNV gain 17666407
esv34155 CNV loss 18971310
esv3577780 CNV loss 25503493
nsv1075716 CNV deletion 25765185
nsv1114948 CNV deletion 24896259
nsv460762 CNV loss 19166990
nsv469549 CNV loss 16826518
nsv470706 CNV loss 18288195
nsv509013 CNV insertion 20534489
nsv515659 CNV loss 19592680
nsv545738 CNV loss 21841781
nsv545741 CNV gain 21841781
nsv834402 CNV loss 17160897
nsv954987 CNV deletion 24416366

Variation tolerance for LDLRAD2 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDLRAD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDLRAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDLRAD2 Gene

Disorders for LDLRAD2 Gene

Relevant External Links for LDLRAD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDLRAD2

No disorders were found for LDLRAD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDLRAD2 Gene

Publications for LDLRAD2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for LDLRAD2 Gene

Sources for LDLRAD2 Gene

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