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Aliases for LDLRAD1 Gene

Aliases for LDLRAD1 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 1 2 3 5
  • Low Density Lipoprotein Receptor A Domain Containing 1 2

External Ids for LDLRAD1 Gene

Previous GeneCards Identifiers for LDLRAD1 Gene

  • GC01M054187
  • GC01M054247
  • GC01M054474
  • GC01M052590

Summaries for LDLRAD1 Gene

GeneCards Summary for LDLRAD1 Gene

LDLRAD1 (Low Density Lipoprotein Receptor Class A Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDLRAD1 Gene

Genomics for LDLRAD1 Gene

Regulatory Elements for LDLRAD1 Gene

Enhancers for LDLRAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F054093 1 Ensembl ENCODE 14.7 -77.4 -77421 3.5 ELF3 FOXA3 MAX CEBPB THRB ZKSCAN1 GABPA NR2F2 ZNF121 SMARCA4 TCEANC2 LDLRAD1 MIR4781 TMEM59 CDCP2 SSBP3-AS1 MRPL37 ENSG00000279049 GC01P054090
GH01F053981 1.2 Ensembl ENCODE 11.7 +35.7 35677 1.8 ELF3 TBP ARID4B DMAP1 THRB ZNF48 RARA YY1 THAP11 SMARCA5 TCEANC2 LRRC42 HSPB11 LDLRAD1 DIO1 YIPF1 TMEM59 MIR4781 HNRNPA3P12 GC01P054015
GH01F054051 1.2 ENCODE 10.5 -35.0 -34969 3.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MAGOH ENSG00000228838 SSBP3-AS1 TCEANC2 RPL37P7 LOC105378729 PODN PARS2 C1orf123 CYB5RL
GH01F054081 1.2 Ensembl ENCODE 10.2 -63.6 -63563 0.3 CBX3 ARID4B RAD21 RARA ZNF121 ZNF766 ZNF143 MIXL1 EGR2 THAP11 TCEANC2 MIR4781 TMEM59 CDCP2 LDLRAD1 HSPB11 LRRC42 SSBP3-AS1 GC01P054077 LOC100507586
GH01F054856 1.3 Ensembl ENCODE 9.3 -841.7 -841670 7.5 MLX ZFP64 ARID4B FEZF1 DMAP1 GATA2 FOS PAF1 SP5 MXD4 ENSG00000233203 DHCR24 LEXM ENSG00000242396 TTC22 ENSG00000237453 LDLRAD1 MIR4781 TCEANC2 TMEM59
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LDLRAD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LDLRAD1 Gene

Chromosome:
1
Start:
54,007,298 bp from pter
End:
54,018,186 bp from pter
Size:
10,889 bases
Orientation:
Minus strand

Genomic View for LDLRAD1 Gene

Genes around LDLRAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDLRAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDLRAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD1 Gene

Proteins for LDLRAD1 Gene

  • Protein details for LDLRAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T700-LRAD1_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 1
    Protein Accession:
    Q5T700
    Secondary Accessions:
    • A0PJY0
    • B7ZME3
    • Q5T6Z9

    Protein attributes for LDLRAD1 Gene

    Size:
    205 amino acids
    Molecular mass:
    21834 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LDLRAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LDLRAD1 Gene

Post-translational modifications for LDLRAD1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LDLRAD1 Gene

Domains & Families for LDLRAD1 Gene

Protein Domains for LDLRAD1 Gene

Suggested Antigen Peptide Sequences for LDLRAD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T700

UniProtKB/Swiss-Prot:

LRAD1_HUMAN :
  • Contains 3 LDL-receptor class A domains.
  • Belongs to the LDLR family.
Domain:
  • Contains 3 LDL-receptor class A domains.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD1: view

No data available for Gene Families for LDLRAD1 Gene

Function for LDLRAD1 Gene

Gene Ontology (GO) - Molecular Function for LDLRAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LDLRAD1: view

Phenotypes for LDLRAD1 Gene

GenomeRNAi human phenotypes for LDLRAD1:
genes like me logo Genes that share phenotypes with LDLRAD1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LDLRAD1 Gene

Localization for LDLRAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDLRAD1 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for LDLRAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LDLRAD1: view

Pathways & Interactions for LDLRAD1 Gene

SuperPathways for LDLRAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LDLRAD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LDLRAD1 Gene

Transcripts for LDLRAD1 Gene

mRNA/cDNA for LDLRAD1 Gene

(7) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDLRAD1 Gene

Low density lipoprotein receptor class A domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD1 Gene

No ASD Table

Relevant External Links for LDLRAD1 Gene

GeneLoc Exon Structure for
LDLRAD1
ECgene alternative splicing isoforms for
LDLRAD1

Expression for LDLRAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LDLRAD1 Gene

mRNA differential expression in normal tissues according to GTEx for LDLRAD1 Gene

This gene is overexpressed in Fallopian Tube (x25.5), Cervix - Endocervix (x9.8), and Lung (x8.2).

NURSA nuclear receptor signaling pathways regulating expression of LDLRAD1 Gene:

LDLRAD1

SOURCE GeneReport for Unigene cluster for LDLRAD1 Gene:

Hs.439583
genes like me logo Genes that share expression patterns with LDLRAD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for LDLRAD1 Gene

Orthologs for LDLRAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LDLRAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDLRAD1 34 35
  • 98.7 (n)
dog
(Canis familiaris)
Mammalia LDLRAD1 34 35
  • 83.01 (n)
cow
(Bos Taurus)
Mammalia LDLRAD1 34 35
  • 81.46 (n)
mouse
(Mus musculus)
Mammalia Ldlrad1 34 16 35
  • 77.95 (n)
rat
(Rattus norvegicus)
Mammalia Ldlrad1 34
  • 77.94 (n)
oppossum
(Monodelphis domestica)
Mammalia LDLRAD1 35
  • 25 (a)
OneToOne
chicken
(Gallus gallus)
Aves LDLRAD1 34 35
  • 62.14 (n)
lizard
(Anolis carolinensis)
Reptilia LDLRAD1 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ldlrad1 34
  • 54.07 (n)
Species where no ortholog for LDLRAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LDLRAD1 Gene

ENSEMBL:
Gene Tree for LDLRAD1 (if available)
TreeFam:
Gene Tree for LDLRAD1 (if available)

Paralogs for LDLRAD1 Gene

No data available for Paralogs for LDLRAD1 Gene

Variants for LDLRAD1 Gene

Sequence variations from dbSNP and Humsavar for LDLRAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10158824 -- 54,014,725(+) CATAA(C/G)CGTGC intron-variant
rs1023213 -- 54,007,105(+) GTGTT(G/T)TTCCC downstream-variant-500B
rs111491582 -- 54,017,147(+) GGCAG(C/T)ACACA intron-variant
rs111676074 -- 54,019,332(+) ATAAC(-/A)GTCGT upstream-variant-2KB
rs111862115 -- 54,014,228(+) TGGCC(A/G/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LDLRAD1 Gene

Variant ID Type Subtype PubMed ID
nsv1003904 CNV gain 25217958
nsv1011262 CNV gain 25217958

Variation tolerance for LDLRAD1 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDLRAD1 Gene

Human Gene Mutation Database (HGMD)
LDLRAD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDLRAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDLRAD1 Gene

Disorders for LDLRAD1 Gene

Relevant External Links for LDLRAD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDLRAD1

No disorders were found for LDLRAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDLRAD1 Gene

Publications for LDLRAD1 Gene

  1. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for LDLRAD1 Gene

Sources for LDLRAD1 Gene

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