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Aliases for LDLRAD1 Gene

Aliases for LDLRAD1 Gene

  • Low Density Lipoprotein Receptor Class A Domain Containing 1 2 3 5
  • Low Density Lipoprotein Receptor A Domain Containing 1 2

External Ids for LDLRAD1 Gene

Previous GeneCards Identifiers for LDLRAD1 Gene

  • GC01M054187
  • GC01M054247
  • GC01M054474
  • GC01M052590

Summaries for LDLRAD1 Gene

GeneCards Summary for LDLRAD1 Gene

LDLRAD1 (Low Density Lipoprotein Receptor Class A Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDLRAD1 Gene

Genomics for LDLRAD1 Gene

Regulatory Elements for LDLRAD1 Gene

Genomic Location for LDLRAD1 Gene

Chromosome:
1
Start:
54,007,298 bp from pter
End:
54,018,186 bp from pter
Size:
10,889 bases
Orientation:
Minus strand

Genomic View for LDLRAD1 Gene

Genes around LDLRAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDLRAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDLRAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDLRAD1 Gene

Proteins for LDLRAD1 Gene

  • Protein details for LDLRAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T700-LRAD1_HUMAN
    Recommended name:
    Low-density lipoprotein receptor class A domain-containing protein 1
    Protein Accession:
    Q5T700
    Secondary Accessions:
    • A0PJY0
    • B7ZME3
    • Q5T6Z9

    Protein attributes for LDLRAD1 Gene

    Size:
    205 amino acids
    Molecular mass:
    21834 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LDLRAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LDLRAD1 Gene

Proteomics data for LDLRAD1 Gene at MOPED

Post-translational modifications for LDLRAD1 Gene

No Post-translational modifications

Other Protein References for LDLRAD1 Gene

Antibody Products

No data available for DME Specific Peptides for LDLRAD1 Gene

Domains & Families for LDLRAD1 Gene

Protein Domains for LDLRAD1 Gene

Suggested Antigen Peptide Sequences for LDLRAD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T700

UniProtKB/Swiss-Prot:

LRAD1_HUMAN :
  • Contains 3 LDL-receptor class A domains.
  • Belongs to the LDLR family.
Domain:
  • Contains 3 LDL-receptor class A domains.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LDLRAD1: view

No data available for Gene Families for LDLRAD1 Gene

Function for LDLRAD1 Gene

Phenotypes for LDLRAD1 Gene

GenomeRNAi human phenotypes for LDLRAD1:
genes like me logo Genes that share phenotypes with LDLRAD1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LDLRAD1 Gene

Localization for LDLRAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDLRAD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDLRAD1 Gene COMPARTMENTS Subcellular localization image for LDLRAD1 gene
Compartment Confidence
plasma membrane 3
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for LDLRAD1 Gene

Pathways & Interactions for LDLRAD1 Gene

SuperPathways for LDLRAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LDLRAD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LDLRAD1 Gene

Drugs & Compounds for LDLRAD1 Gene

No Compound Related Data Available

Transcripts for LDLRAD1 Gene

mRNA/cDNA for LDLRAD1 Gene

(7) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDLRAD1 Gene

Low density lipoprotein receptor class A domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LDLRAD1 Gene

No ASD Table

Relevant External Links for LDLRAD1 Gene

GeneLoc Exon Structure for
LDLRAD1
ECgene alternative splicing isoforms for
LDLRAD1

Expression for LDLRAD1 Gene

mRNA expression in normal human tissues for LDLRAD1 Gene

mRNA differential expression in normal tissues according to GTEx for LDLRAD1 Gene

This gene is overexpressed in Fallopian Tube (x25.5), Cervix - Endocervix (x9.8), and Lung (x8.2).

SOURCE GeneReport for Unigene cluster for LDLRAD1 Gene Hs.439583

genes like me logo Genes that share expression patterns with LDLRAD1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LDLRAD1 Gene

Orthologs for LDLRAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LDLRAD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LDLRAD1 35
  • 81.46 (n)
  • 79.51 (a)
LDLRAD1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LDLRAD1 35
  • 83.01 (n)
  • 82.35 (a)
LDLRAD1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ldlrad1 35
  • 77.95 (n)
  • 75.52 (a)
Ldlrad1 16
Ldlrad1 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LDLRAD1 35
  • 98.7 (n)
  • 98.54 (a)
LDLRAD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ldlrad1 35
  • 77.94 (n)
  • 70.59 (a)
oppossum
(Monodelphis domestica)
Mammalia LDLRAD1 36
  • 25 (a)
OneToOne
chicken
(Gallus gallus)
Aves LDLRAD1 35
  • 62.14 (n)
  • 51.26 (a)
LDLRAD1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LDLRAD1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ldlrad1 35
  • 54.07 (n)
  • 48.84 (a)
Species with no ortholog for LDLRAD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LDLRAD1 Gene

ENSEMBL:
Gene Tree for LDLRAD1 (if available)
TreeFam:
Gene Tree for LDLRAD1 (if available)

Paralogs for LDLRAD1 Gene

No data available for Paralogs for LDLRAD1 Gene

Variants for LDLRAD1 Gene

Sequence variations from dbSNP and Humsavar for LDLRAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs914720 -- 54,018,809(+) CCTGT(C/T)CCACT upstream-variant-2KB
rs928441 -- 54,007,695(+) TTCCA(A/C)CTCAG utr-variant-3-prime
rs928442 -- 54,007,815(+) GAAAG(C/G)CTTCT utr-variant-3-prime
rs928443 -- 54,007,843(+) GCTGT(A/C/G)TTTGG utr-variant-3-prime
rs928444 -- 54,007,875(+) TTGCT(C/G)TATGA utr-variant-3-prime

Variation tolerance for LDLRAD1 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDLRAD1 Gene

HapMap Linkage Disequilibrium report
LDLRAD1
Human Gene Mutation Database (HGMD)
LDLRAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LDLRAD1 Gene

Disorders for LDLRAD1 Gene

Relevant External Links for LDLRAD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDLRAD1

No disorders were found for LDLRAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDLRAD1 Gene

Publications for LDLRAD1 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 67
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for LDLRAD1 Gene

Sources for LDLRAD1 Gene

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