Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LDHD Gene

protein-coding   GIFtS: 56
GCID: GC16M075145

Lactate Dehydrogenase D

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lactate Dehydrogenase D1 2 3
DLD2 3
D-Lactate Dehydrogenase2
Probable D-Lactate Dehydrogenase, Mitochondrial2
EC 1.1.2.43

External Ids:    HGNC: 197081   Entrez Gene: 1972572   Ensembl: ENSG000001668167   OMIM: 6074905   UniProtKB: Q86WU23   

Export aliases for LDHD gene to outside databases

Previous GC identifers: GC16M076106 GC16M074884 GC16M074925 GC16M073703 GC16M060896


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LDHD Gene:
The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar
protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this
locus and two transcript variants encoding distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for LDHD Gene: 
LDHD (lactate dehydrogenase D) is a protein-coding gene. Diseases associated with LDHD include hodgkin's lymphoma, mixed cellularity, and clostridium difficile, and among its related super-pathways are methylglyoxal degradation VI and Post-translational protein modification. GO annotations related to this gene include flavin adenine dinucleotide binding and D-lactate dehydrogenase (cytochrome) activity. An important paralog of this gene is AGPS.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LDHD gene promoter:
         AML1a   p53   Pax-5   MyoD   MEF-2A   PPAR-gamma1   SEF-1 (1)   aMEF-2   PPAR-gamma2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLDHD promoter sequence
   Search SABiosciences Chromatin IP Primers for LDHD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDHD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22.3

LDHD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LDHD gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M075145:  view genomic region     (about GC identifiers)

Start:
75,145,758 bp from pter      End:
75,150,670 bp from pter
Size:
4,913 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LDHD_HUMAN, Q86WU2 (See protein sequence)
Recommended Name: Probable D-lactate dehydrogenase, mitochondrial precursor  
Size: 507 amino acids; 54871 Da
Cofactor: FAD (By similarity)
Subunit: Interacts with CSRP3
Subcellular location: Mitochondrion (By similarity)
Sequence caution: Sequence=AAM50322.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q8IZK5
Alternative splicing: 2 isoforms:  Q86WU2-1   Q86WU2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LDHD: NX_Q86WU2

Explore proteomics data for LDHD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86WU2

  • LDHD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LDHD Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_705690.2  NP_919417.1  

    ENSEMBL proteins: 
     ENSP00000300051   ENSP00000417011   ENSP00000454260  
    Reactome Protein details: Q86WU2
    Human Recombinant Protein Products for LDHD: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LDHD
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for LDHD
    GenScript Custom Purified and Recombinant Proteins Services for LDHD
    Novus Biologicals LDHD Protein
    Novus Biologicals LDHD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LDHD 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005743mitochondrial inner membrane IEA--

    LDHD for ontologies           About GeneDecksing



    LDHD Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LDHD
    GenScript Custom Superior Antibodies Services for LDHD
    Novus Biologicals LDHD Antibodies
    Abcam antibodies for LDHD
    Cloud-Clone Corp. Antibodies for LDHD 
    ThermoFisher Antibody for LDHD
    LSBio Antibodies in human, mouse, rat for LDHD 

    Assay Products for LDHD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LDHD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LDHD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LDHD 
    Cloud-Clone Corp. CLIAs for LDHD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR016167 FAD-bd_2_sub1
     IPR016166 FAD-bd_2
     IPR004113 FAD-linked_oxidase_C
     IPR016171 Vanillyl_alc_oxidase_C-sub2
     IPR016169 CO_DH_flavot_FAD-bd_sub2

    Graphical View of Domain Structure for InterPro Entry Q86WU2

    ProtoNet protein and cluster: Q86WU2

    1 Blocks protein domain: IPB004113 FAD linked oxidase

    UniProtKB/Swiss-Prot: LDHD_HUMAN, Q86WU2
    Similarity: Belongs to the FAD-binding oxidoreductase/transferase type 4 family
    Similarity: Contains 1 FAD-binding PCMH-type domain


    LDHD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LDHD_HUMAN, Q86WU2
    Catalytic activity: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+)

         Enzyme Number (IUBMB): EC 1.1.2.41

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004458D-lactate dehydrogenase (cytochrome) activity IEA--
    GO:0005515protein binding IPI12127981
    GO:0008762UDP-N-acetylmuramate dehydrogenase activity IEA--
    GO:0016491oxidoreductase activity ----
         
    LDHD for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LDHD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LDHD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LDHD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LDHD 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LDHD
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LDHD
    SwitchGear 3'UTR luciferase reporter plasmidLDHD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LDHD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LDHD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LDHD
    Sirion Biotech Customized adenovirus for overexpression of LDHD

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LDHD (see all 11)
    OriGene ORF clones in mouse, rat for LDHD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LDHD (NM_153486)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LDHD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDHD
    Sirion Biotech Customized lentivirus for stable overexpression of LDHD 
                         Customized lentivirus expression plasmids for stable overexpression of LDHD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LDHD
    Search LifeMap BioReagents cell lines for LDHD
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDHD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LDHD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1methylglyoxal degradation I
    methylglyoxal degradation I0.50
    methylglyoxal degradation VI0.50
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    3Pyruvate metabolism
    Pyruvate metabolism
    4Mitochondrial Protein Import
    Mitochondrial Protein Import
    5Metabolic States and Circadian Oscillators
    Metabolic States and Circadian Oscillators

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LDHD
        Metabolic States and Circadian Oscillators

    2 BioSystems Pathways for LDHD
        methylglyoxal degradation I
    methylglyoxal degradation VI

    2        Reactome Pathways for LDHD
        Mitochondrial Protein Import
    Metabolism of proteins


    1         Kegg Pathway  (Kegg details for LDHD):
        Pyruvate metabolism


    LDHD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LDHD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/35 Interacting proteins for LDHD (Q86WU23 ENSP000003000514) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSRP3P504613, ENSP000002659684I2D: score=2 STRING: ENSP00000265968
    OXSMQ9NWU13, ENSP000002807014I2D: score=1 STRING: ENSP00000280701
    PKMP146183, ENSP000003201714I2D: score=1 STRING: ENSP00000320171
    ACOX1Q150673I2D: score=1 
    CADP277083I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    LDHD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LDHD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LDHD

    3 HMDB Compounds for LDHD    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Lactic acid(-)-Lactate (see all 35)10326-41-7--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    4 Novoseek inferred chemical compound relationships for LDHD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactate 68 31 8289259 (2), 18623312 (2), 9525904 (2), 2044942 (2) (see all 17)
    nad+ 59.5 3 8289259 (1), 18623312 (1), 9126843 (1)
    pyruvate 55.1 1 18574566 (1)
    nadh 53.6 1 7702618 (1)

    Search CenterWatch for drugs/clinical trials and news about LDHD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LDHD gene (2 alternative transcripts): 
    NM_153486.3  NM_194436.2  

    Unigene Cluster for LDHD:

    Lactate dehydrogenase D
    Hs.380929  [show with all ESTs]
    Unigene Representative Sequence: NM_153486
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300051(uc002fdn.3 uc002fdm.3) ENST00000450168 ENST00000568164
    ENST00000569876
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LDHD
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LDHD
    SwitchGear 3'UTR luciferase reporter plasmidLDHD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LDHD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LDHD
    Clone
    Products:
         
    OriGene clones in human, mouse for LDHD (see all 11)
    OriGene ORF clones in mouse, rat for LDHD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LDHD (NM_153486)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LDHD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDHD
    Sirion Biotech Customized lentivirus for stable overexpression of LDHD 
                         Customized lentivirus expression plasmids for stable overexpression of LDHD 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LDHD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LDHD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDHD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDHD

    Additional mRNA sequence: 

    AY092767.1 BC040279.1 BC047902.1 

    5 DOTS entries:

    DT.442437  DT.100019816  DT.97843918  DT.97779618  DT.91801041 

    24/56 AceView cDNA sequences (see all 56):

    BI517972 BM931918 BM922079 BM930896 BC047902 BM741657 BI821082 NM_194436 
    BC040279 BX114620 BM820371 BM763726 BM684415 NM_153486 BM764518 BQ889447 
    BI761255 BM759366 BI517362 BI758772 BQ066939 BI517339 BM764562 BM743741 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LDHD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:              -                                               -                                                   
    SP2:              -                                               -     -                                             
    SP3:                                                                                                                  
    SP4:              -                       -                                                                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for LDHD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LDHD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGATAGGTC
    LDHD Expression
    About this image


    See LDHD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LDHD

    SOURCE GeneReport for Unigene cluster: Hs.380929

    UniProtKB/Swiss-Prot: LDHD_HUMAN, Q86WU2
    Tissue specificity: Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney

        SABiosciences Custom PCR Arrays for LDHD
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LDHD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LDHD
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDHD
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDHD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDHD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LDHD gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ldhd1 , 5 lactate dehydrogenase D1, 5 81.96(n)1
    85.33(a)1
      8 (57.98 cM)5
    528151  NM_027570.31  NP_081846.31 
     1116237855 
    chicken
    (Gallus gallus)
    Aves LDHD1 lactate dehydrogenase D, mitochondrial 72.89(n)
    71.11(a)
      415689  XM_003641905.1  XP_003641953.1 
    lizard
    (Anolis carolinensis)
    Reptilia LDHD6
    lactate dehydrogenase D
    48(a)
    1 ↔ 1
    GL343840.1(11402-14718)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.251102 Xenopus laevis transcribed sequence with weak similarity more 69.04(n)    CB755986.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi36b042 wufi36b04 73.98(n)   334208  BC044171.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F32D8.121 Protein F32D8.12 50.89(n)
    52.89(a)
      179506  NM_001028701.2  NP_001023872.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DLD1(YDL174C)4
    DLD11
    D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, more4
    Dld1p1
    46.53(n)1
    37.14(a)1
      4(147589-145826)4
    8513801, 4  NP_010107.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G065801 D-lactate dehydrogenase [cytochrome] 48.6(n)
    43.14(a)
      830546  NM_120741.2  NP_568170.1 


    ENSEMBL Gene Tree for LDHD (if available)
    TreeFam Gene Tree for LDHD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LDHD gene
    AGPS2  

    LDHD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/292 SNPs in LDHD are shown (see all 292)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486302331,2
    --75145423(+) TGGTAC/TGATAC 2 -- ds50010--------
    rs1878331601,2
    --75145446(+) AGAGGC/TGGGTG 2 -- ds50010--------
    rs1928791041,2
    --75145449(+) GGTGGA/GTGCAA 2 -- ds50010--------
    rs116480821,2
    C,F,A,H--75145538(+) CCCAGT/CTGGGG 2 -- ds500118Minor allele frequency- C:0.37NS EA NA 2226
    rs1421234061,2
    --75145558(+) TGAGTC/GACATG 2 -- ds50010--------
    rs1166539891,2
    C,F--75145652(+) CTCCCC/TAGGCT 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs32172561,2
    C--75145821(-) ATGATGAT/-AGGTC 2 -- cds11Minor allele frequency- -:0.50NA 2
    rs353321551,2
    C--75145823(+) ATCAT-/CATGTCAC 2 -- cds10--------
    rs1478075631,2
    --75145843(+) GCTCAC/TGTTCC 2 -- ut310--------
    rs1831105261,2
    --75145960(+) CAGACA/GCTCTC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LDHD (75145758 - 75150670 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LDHD: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing LDHD
    DNA2.0 Custom Variant and Variant Library Synthesis for LDHD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607490    OMIM disorders: --

    6 diseases for LDHD:    About MalaCards
    hodgkin's lymphoma, mixed cellularity    clostridium difficile    osteopetrosis    hodgkin's lymphoma
    tuberculosis    neuronitis


    LDHD for disorders           About GeneDecksing

    Genetic Association Database (GAD): LDHD
    Human Genome Epidemiology (HuGE) Navigator: LDHD (2 documents)

    Export disorders for LDHD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LDHD gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with LDHD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of putative mammalian D-lactate dehydrogenase enzymes. (PubMed id 12127981)1, 2, 3 Flick M.J. and Konieczny S.F. (2002)
    2. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (2010)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Prostate cancer cells metabolize d-lactate inside mito chondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. (PubMed id 23333299)1 de Bari L....Passarella S. (2013)
    6. Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease. (PubMed id 23665963)1 Dubinsky M.C....McGovern D.P. (2013)
    7. Elevated serum lactate dehydrogenase isoenzymes and a spartate transaminase distinguish Albers-SchAPnberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders. (PubMed id 20499337)1 Whyte M.P....Wenkert D. (2010)
    8. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Protective effect of glutathione in HIV-1 lytic peptide 1-induced cell death in human neuronal cells. (PubMed id 11582518)1 Sung J.H....Chong Y.H. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 197257 HGNC: 19708 AceView: LDHD Ensembl:ENSG00000166816 euGenes: HUgn197257
    ECgene: LDHD Kegg: 197257 H-InvDB: LDHD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LDHD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LDHD gene:
    Search GeneIP for patents involving LDHD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for LDHD  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for LDHD  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LDHD  
     OriGene qSTAR qPCR primer pairs in human, mouse for LDHD   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LDHD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LDHD   OriGene Custom Protein Services for LDHD  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LDHD
     QIAGEN SeqTarget long-range PCR primers for resequencing LDHD
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDHD
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LDHD
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDHD
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDHD
     GenScript Custom Purified and Recombinant Proteins Services for LDHD GenScript cDNA clones with any tag delivered in your preferred vector for LDHD
     GenScript Custom Assay Services for LDHD GenScript Custom Superior Antibodies Services for LDHD
     GenScript Custom overexpressing Cell Line Services for LDHD CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LDHD promoter
     Search Chromatin IP Primers for LDHD
     RT2 qPCR Primer Assay in human, mouse, rat LDHD
     Search GNC Networks for LDHD
     SABiosciences PCR Arrays including human, mouse, rat LDHD
     Search Tocris compounds for LDHD
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LDHD antibodies
     LDHD proteins
     LDHD lysates
     Antibodies for LDHD
     See all of Abcam's Antibodies, Kits and Proteins for LDHD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for LDHD
     Antibodies for LDHD
     ELISAs for LDHD
     CLIAs for LDHD
     Search LifeMap BioReagents cell lines for LDHD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDHD
     SwitchGear 3'UTR luciferase reporter plasmids for LDHD
     SwitchGear Promoter luciferase reporter plasmids for LDHD
     ThermoFisher Antibody for LDHD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDHD
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LDHD
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LDHD
    Customized:
     lentivirus for stable overexpression of LDHD
     lentivirus expression plasmids for stable overexpression of LDHD
     adenovirus for overexpression of LDHD
     LSBio Antibodies in human, mouse, rat for LDHD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LDHD gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4