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Aliases for LDHC Gene

Aliases for LDHC Gene

  • Lactate Dehydrogenase C 2 3 5
  • Cancer/Testis Antigen 32 2 3 4
  • LDH Testis Subunit 3 4
  • EC 1.1.1.27 4 63
  • LDH-C 3 4
  • LDH-X 3 4
  • CT32 3 4
  • LDH3 3 4
  • LDHX 3 4
  • Testis Secretory Sperm-Binding Protein Li 234P 3
  • Lactate Dehydrogenase C Variant 1 3
  • Lactate Dehydrogenase C Variant 3 3
  • Lactate Dehydrogenase C Variant 4 3
  • Lactate Dehydrogenase C Variant 5 3
  • Lactate Dehydrogenase C4 3
  • EC 1.1.1 63

External Ids for LDHC Gene

Previous GeneCards Identifiers for LDHC Gene

  • GC11P019555
  • GC11P019376
  • GC11P018473
  • GC11P018398
  • GC11P018390
  • GC11P018119

Summaries for LDHC Gene

Entrez Gene Summary for LDHC Gene

  • Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for LDHC Gene

LDHC (Lactate Dehydrogenase C) is a Protein Coding gene. Diseases associated with LDHC include phototoxic dermatitis and non-gestational choriocarcinoma. Among its related pathways are Metabolism and Propanoate metabolism. GO annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHA.

UniProtKB/Swiss-Prot for LDHC Gene

  • Possible role in sperm motility.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHC Gene

Genomics for LDHC Gene

Regulatory Elements for LDHC Gene

Promoters for LDHC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LDHC on UCSC Golden Path with GeneCards custom track

Genomic Location for LDHC Gene

Chromosome:
11
Start:
18,412,306 bp from pter
End:
18,452,058 bp from pter
Size:
39,753 bases
Orientation:
Plus strand

Genomic View for LDHC Gene

Genes around LDHC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDHC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDHC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHC Gene

Proteins for LDHC Gene

  • Protein details for LDHC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07864-LDHC_HUMAN
    Recommended name:
    L-lactate dehydrogenase C chain
    Protein Accession:
    P07864
    Secondary Accessions:
    • D3DQY4
    • Q6GSG8
    • Q7Z7J4

    Protein attributes for LDHC Gene

    Size:
    332 amino acids
    Molecular mass:
    36311 Da
    Quaternary structure:
    • Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity).

neXtProt entry for LDHC Gene

Proteomics data for LDHC Gene at MOPED

Post-translational modifications for LDHC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LDHC (LDH-C)

Domains & Families for LDHC Gene

Suggested Antigen Peptide Sequences for LDHC Gene

Graphical View of Domain Structure for InterPro Entry

P07864

UniProtKB/Swiss-Prot:

LDHC_HUMAN :
  • Belongs to the LDH/MDH superfamily. LDH family.
Family:
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHC: view

No data available for Gene Families for LDHC Gene

Function for LDHC Gene

Molecular function for LDHC Gene

GENATLAS Biochemistry:
lactate dehydrogenase C,glycolysis,energy pathway
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH.
UniProtKB/Swiss-Prot Function:
Possible role in sperm motility.

Enzyme Numbers (IUBMB) for LDHC Gene

genes like me logo Genes that share phenotypes with LDHC: view

Animal Models for LDHC Gene

MGI Knock Outs for LDHC:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LDHC Gene

Localization for LDHC Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDHC Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDHC Gene COMPARTMENTS Subcellular localization image for LDHC gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
plasma membrane 2
cytoskeleton 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LDHC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005929 cilium IEA --
GO:0031514 motile cilium IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with LDHC: view

Pathways & Interactions for LDHC Gene

genes like me logo Genes that share pathways with LDHC: view

UniProtKB/Swiss-Prot P07864-LDHC_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Interacting Proteins for LDHC Gene

Gene Ontology (GO) - Biological Process for LDHC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process IEA,TAS --
GO:0019244 lactate biosynthetic process from pyruvate IEA --
GO:0019516 lactate oxidation IEA --
GO:0030317 sperm motility IEA --
genes like me logo Genes that share ontologies with LDHC: view

No data available for SIGNOR curated interactions for LDHC Gene

Drugs & Compounds for LDHC Gene

(7) Drugs for LDHC Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra 0
2-Ketobutyric acid Experimental Pharma 0
NADH Nutra Target 0
L-lactic acid Pharma Full agonist, Agonist 0
NAD Pharma Full agonist, Agonist 0

(7) Additional Compounds for LDHC Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
  • (RS)-2-Hydroxybutyric acid
  • 2-Hydroxy-Butanoate
  • 2-Hydroxy-Butanoic acid
  • 2-Hydroxy-DL-Butyrate
600-15-7
3-Mercaptolactic acid
  • 3-Mercaptolactate
  • b-Mercaptolactate
  • b-Mercaptolactic acid
  • beta-Mercaptolactate
  • beta-Mercaptolactic acid
2614-83-7
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
2464-23-5
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with LDHC: view

Transcripts for LDHC Gene

Unigene Clusters for LDHC Gene

Lactate dehydrogenase C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LDHC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - -

Relevant External Links for LDHC Gene

GeneLoc Exon Structure for
LDHC
ECgene alternative splicing isoforms for
LDHC

Expression for LDHC Gene

mRNA expression in normal human tissues for LDHC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDHC Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for LDHC Gene

This gene is overexpressed in Ovary (19.4), Amniocyte (17.7), Bone marrow mesenchymal stem cell (16.8), and Testis (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LDHC Gene



SOURCE GeneReport for Unigene cluster for LDHC Gene Hs.654377

genes like me logo Genes that share expression patterns with LDHC: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LDHC Gene

Orthologs for LDHC Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDHC 36
  • 100 (a)
OneToOne
LDHC 35
  • 99.9 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia LDHC 35
  • 88.96 (n)
  • 86.14 (a)
LDHC 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LDHC 36
  • 84 (a)
OneToOne
LDHC 35
  • 90.86 (n)
  • 88.55 (a)
mouse
(Mus musculus)
Mammalia Ldhc 36
  • 74 (a)
OneToOne
Ldhc 16
Ldhc 35
  • 79.49 (n)
  • 74.55 (a)
oppossum
(Monodelphis domestica)
Mammalia LDHC 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ldhc 35
  • 77.98 (n)
  • 73.33 (a)
chicken
(Gallus gallus)
Aves LDHA 36
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ldha 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13334 37
  • 38 (a)
ImpL3 37
  • 58 (a)
CG13334 36
  • 35 (a)
ManyToMany
ImpL3 36
  • 58 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ldh-1 36
  • 57 (a)
OneToMany
ldh-1 37
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 36
  • 55 (a)
OneToMany
Species with no ortholog for LDHC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LDHC Gene

ENSEMBL:
Gene Tree for LDHC (if available)
TreeFam:
Gene Tree for LDHC (if available)

Paralogs for LDHC Gene

Paralogs for LDHC Gene

genes like me logo Genes that share paralogs with LDHC: view

Variants for LDHC Gene

Sequence variations from dbSNP and Humsavar for LDHC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2230150 - 18,450,981(+) TAAAA(C/G/T)AAGAA reference, missense
rs171495 -- 18,439,902(+) cacaa(A/G)aattg intron-variant
rs968895 -- 18,448,756(+) TTTTT(G/T)TGTGT intron-variant
rs1406580 -- 18,448,758(+) TTTGT(G/T)TGTCA intron-variant
rs1506519 -- 18,420,399(+) AAGTT(C/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LDHC Gene

Variant ID Type Subtype PubMed ID
nsv509392 CNV Insertion 20534489
nsv510999 CNV Complex 20534489
nsv897027 CNV Loss 21882294
esv2671789 CNV Deletion 23128226
nsv467719 CNV Gain 19166990

Variation tolerance for LDHC Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDHC Gene

HapMap Linkage Disequilibrium report
LDHC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHC Gene

Disorders for LDHC Gene

MalaCards: The human disease database

(5) MalaCards diseases for LDHC Gene - From: DISEASES

Disorder Aliases PubMed IDs
phototoxic dermatitis
  • photosensitisation reaction
non-gestational choriocarcinoma
  • choriocarcinoma, non-gestational
breast abscess
  • abscess of breast
dressler's syndrome
  • dressler syndrome
korean hemorrhagic fever
  • hemorrhagic fever with renal syndrome
- elite association - COSMIC cancer census association via MalaCards
Search LDHC in MalaCards View complete list of genes associated with diseases

Relevant External Links for LDHC

Genetic Association Database (GAD)
LDHC
Human Genome Epidemiology (HuGE) Navigator
LDHC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDHC
genes like me logo Genes that share disorders with LDHC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LDHC Gene

Publications for LDHC Gene

  1. A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications. (PMID: 14985855) Wang H. … Sha J. (J. Mol. Med. 2004) 3 4 23 67
  2. Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation. (PMID: 18930904) Tang H. … Goldberg E. (J. Androl. 2009) 3 23
  3. Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer. (PMID: 12438276) Koslowski M. … Sahin U. (Cancer Res. 2002) 3 23
  4. Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli. (PMID: 1996957) LeVan K.M. … Goldberg E. (Biochem. J. 1991) 3 23
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for LDHC Gene

Sources for LDHC Gene

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