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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LDHC Gene

protein-coding   GIFtS: 61
GCID: GC11P018433

lactate dehydrogenase C
 Explore 21 diseases affiliated with
LDHC via
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Biological research products
for LDHC    

Aliases
for LDHC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Lactate Dehydrogenase C1 2     EC 1.1.1.273 8
CT321 2 3     L-Lactate Dehydrogenase C Chain2
LDH32 3 5     Lactate Dehydrogenase C Variant 12
Cancer/Testis Antigen 322 3     Lactate Dehydrogenase C Variant 32
LDH-C2 3     Lactate Dehydrogenase C Variant 42
LDH-X2 3     Lactate Dehydrogenase C42
LDHX2 3     EC 1.1.18
LDH Testis Subunit2 3     

External Ids:    HGNC: 65441   Entrez Gene: 39482   Ensembl: ENSG000001667967   OMIM: 1501505   UniProtKB: P078643   

Export aliases for LDHC gene to outside databases

Previous GC identifers: GC11P019555 GC11P019376 GC11P018473 GC11P018398 GC11P018390 GC11P018119


Summaries
for LDHC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LDHC:
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of
anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants
have been detected which differ in the 5' untranslated region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LDHC_HUMAN, P07864
Function: Possible role in sperm motility




Genomic Views
for LDHC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LDHC gene promoter:
         CREB   POU2F1   POU2F1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LDHC promoter sequence
   Search SABiosciences Chromatin IP Primers for LDHC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDHC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

LDHC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LDHC gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018433:  view genomic region     (about GC identifiers)

Start:
 18,433,853 bp from pter      End:
 18,473,605 bp from pter
Size:
 39,753 bases      Orientation:
 plus strand

Proteins
for LDHC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LDHC_HUMAN, P07864 (See protein sequence)
Recommended Name: L-lactate dehydrogenase C chain  
Size: 332 amino acids; 36311 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
Secondary accessions: D3DQY4 Q6GSG8 Q7Z7J4

Explore the universe of human proteins at neXtProt for LDHC: NX_P07864

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07864

    • 4/20 DME Specific Peptides for LDHC (P07864) (see all 20)
     NLRRVHP  NPVDILT  LDSARFR  IKLKGYT 

    LDHC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002292.1  NP_059144.1  

    ENSEMBL proteins: 
     ENSP00000437783   ENSP00000379518   ENSP00000280704   ENSP00000438196   ENSP00000441991  
     ENSP00000443414   ENSP00000439555   ENSP00000441478   ENSP00000439060   ENSP00000443997  

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    Novus Biologicals LDHC Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LDHC

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    LDHC for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for LDHC

    Protein Domains /
    Families
    for LDHC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LDHC for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001236 Lactate/malate_DH_N
     IPR018177 L-lactate_DH_AS
     IPR022383 Lactate/malate_DH_C
     IPR015955 Lactate_DH/Glyco_Ohase_4_C
     IPR011304 L-lactate_DH

    Graphical View of Domain Structure for InterPro Entry P07864

    ProtoNet protein and cluster: P07864

    2 Blocks protein families:
    IPB001557 L-lactate dehydrogenase
    IPB011304 L-lactate dehydrogenase


    UniProtKB/Swiss-Prot: LDHC_HUMAN, P07864
    Similarity: Belongs to the LDH/MDH superfamily. LDH family


    Function
    for LDHC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LDHC_HUMAN, P07864
    Function: Possible role in sperm motility
    Catalytic activity: (S)-lactate + NAD(+) = pyruvate + NADH

         Genatlas biochemistry entry for LDHC:
    lactate dehydrogenase C,glycolysis,energy pathway

    Enzyme Numbers (IUBMB): EC 1.1.1.271 2 EC 1.1.12

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LDHC:
    hsa-miR-26b* hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmid: LDHC 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LDHC (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0004459L-lactate dehydrogenase activity IEA--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----


    LDHC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Ldhctm1Erg for LDHC
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ldhc):
     endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    LDHC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LDHC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription_CREM signaling in testis
    		Transcription_CREM signaling in testis1.00
    		Transcription CREM signaling in testis0.96
    2Glycolysis and gluconeogenesis (short map)
    		Glycolysis and Gluconeogenesis0.60
    		Glycolysis / Gluconeogenesis0.41
    3Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00
    4Pyruvate metabolism
    		Pyruvate metabolism1.00
    5Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for LDHC
        Transcription CREM signaling in testis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LDHC
        Metabolic States and Circadian Oscillators

    1 Cell Signaling Technology (CST) Pathway for LDHC
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for LDHC
        Transcription CREM signaling in testis

    1 BioSystems Pathway for LDHC 
        Glycolysis and Gluconeogenesis


    5         Kegg Pathways  (Kegg details for LDHC):
        Glycolysis / Gluconeogenesis
    Cysteine and methionine metabolism
    Pyruvate metabolism
    Propanoate metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: LDHC_HUMAN, P07864
    Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1


    LDHC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LDHC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for LDHC (ENSP000002807044) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOT1ENSP000003595394STRING: ENSP00000359539
    GOT2ENSP000002452064STRING: ENSP00000245206
    LDHDENSP000003000514STRING: ENSP00000300051
    ME1ENSP000003587194STRING: ENSP00000358719
    ME2ENSP000003210704STRING: ENSP00000321070
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process ----
    GO:0006096glycolysis IEA--
    GO:0006754ATP biosynthetic process IEA--
    GO:0019244lactate biosynthetic process from pyruvate IEA--
    GO:0019516lactate oxidation IEA--


    LDHC for ontologies           About GeneDecksing



    Drugs & Compounds
    for LDHC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LDHC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LDHC

    8 HMDB Compounds for LDHC    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxybutyric acid(RS)-2-Hydroxybutyrate (see all 29)600-15-7--
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
    3-Mercaptolactic acid3-mercaptolactate (see all 5)2614-83-7--
    3-Mercaptopyruvic acid3-Mercaptopyruvate (see all 13)2464-23-5--
    L-Lactic acid(+)-Lactate (see all 35)79-33-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    1 DrugBank Compound for LDHC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--182529 2751392 3735252 17139284 17016423

    5 Novoseek chemical compound relationships for LDHC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactate 72.6 30 12438276 (5), 20106611 (1), 1530367 (1), 9364765 (1) (see all 15)
    percoll 43.9 2 8005703 (1), 1879960 (1)
    creatinine 24 8 16140088 (3), 8005703 (1), 9052941 (1)
    testosterone 1.22 2 1530367 (1)
    atp 0 6 8005703 (5), 12438276 (1)

    Search CenterWatch for drugs/clinical trials and news about LDHC 

    Transcripts
    for LDHC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LDHC gene (2 alternative transcripts): 
    NM_002301.4  NM_017448.3  

    Unigene Cluster for LDHC:

    Lactate dehydrogenase C
    Hs.654377  [show with all ESTs]
    Unigene Representative Sequence: BC064388
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541669(uc001mon.4 uc009yhp.3 uc001moo.4 uc009yhq.3 uc009yhr.3)
    ENST00000396215 ENST00000280704(uc001mom.4) ENST00000545848 ENST00000539369
    ENST00000546146 ENST00000536880 ENST00000537486 ENST00000544105 ENST00000535809


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LDHC
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LDHC:
    hsa-miR-26b* hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmid: LDHC 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF401094.1 AF401095.1 AF401096.1 AF401097.1 AK058181.1 AY286300.1 BC019249.2 BC064388.1 
    BC090043.1 GU479374.1 HQ386000.1 HQ386001.1 HQ386002.1 HQ386003.1 HQ386004.1 HQ386005.1 
    J02938.1 U13680.1 

    6 DOTS entries:

    DT.95073825  DT.100754652  DT.91711255  DT.100023858  DT.86847104  DT.95246426 

    24/68 AceView cDNA sequences (see all 68):

    AK058181 BC019249 AA397619 BC064388 AF401096 CD557274 AL041762 BI560103 
    BG723377 J02938 AW515709 AL048740 BU853632 NM_002301 BG717645 U13680 
    AA461531 BQ429474 BI460557 AA460603 BI462531 BI545270 BI825705 BU854478 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LDHC (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -                                                   
    SP2:                                                                  
    SP3:              -           -                                       
    SP4:              -                                   -               
    SP5:              -           -     -                                 


    ECgene alternative splicing isoforms for LDHC

    Expression
    for LDHC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LDHC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LDHC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesMature Sertoli CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LDHC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LDHC

    SOURCE GeneReport for Unigene cluster: Hs.654377
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    In Situ
    Assay Products:     
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    Orthologs
    for LDHC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LDHC gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves E1BTT8_CHICK6
    		 lactate dehydrogenase A
    		 71(a)
    		 1 → many
    		 5(13644404-13650368)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 71(a)
    		 1 → many
    		 1(67804302-67811950)
    zebrafish
    (Danio rerio)    		 Actinopterygii ldha6
    		 lactate dehydrogenase A4
    		 68(a)
    		 1 → many
    		 25(25749747-25758098)
    fruit fly
    (Drosophila melanogaster)    		 Insecta ImpL33 glycolysis L-lactate dehydrogenase 58(a)
    (best of 2)    		   65A11   --
    worm
    (Caenorhabditis elegans)    		 Secernentea ldh-13 L-lactate dehydrogenase 59(a)   II(11725228-11726333)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G172606
    		 L-lactate dehydrogenase
    		 46(a)
    		 1 → many
    		 4(9673991-9675448)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 lactate/malate dehydrogenase, putative, expressed
    		 44(a)
    40(a)
    		 many ↔ many
    many ↔ many
    		 6(345985-347516)
    2(295302-299174)


    ENSEMBL Gene Tree for LDHC (if available)
    TreeFam Gene Tree for LDHC (if available) 

    Paralogs
    for LDHC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LDHC gene
    UEVLD2  LDHAL6B2  LDHB2  LDHA2  LDHAL6A2  
    5 SIMAP similar genes for LDHC using alignment to 13 protein entries:     LDHC_HUMAN (see all proteins):
    LDHA    LDHB    LDHAL6A    LDHAL6B    UEVLD

    LDHC for paralogs           About GeneDecksing



    Genomic Variants
    for LDHC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/867 NCBI SNPs in LDHC are shown (see all 867)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs793921181,2
    		F,--18117184(+) ATTTTG/TGTTCT 2 -- us2k11Minor allele frequency- T:0.07WA 118
    rs745625651,2
    		F,--18117292(+) GGCCAC/TTACCA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs745091081,2
    		C,--18117578(+) AATGAG/CGAATT 2 -- us2k12Minor allele frequency- C:0.02WA 120
    rs1126230141,2
    		F,--18117636(+) CAAAAC/AGTCCT 2 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs1150328261,2
    		C,F,--18117790(+) CGGAAG/AAGTTT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs778276181,2
    		F,--18117851(+) GGGTGC/TGGTGG 2 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1121492041,2
    		--18118155(+) TTACTC/TGGGAG 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1122679491,2
    		C,--18118194(+) GGCGGC/TGGAGG 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1115154631,2
    		--18118611(+) TTTTTG/AGTAGA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs47576611,2
    		C,F,H,--18118812(+) CTGTTC/TTCTCA 2 -- us2k111Minor allele frequency- T:0.03NS EA NA 1182

    HapMap Linkage Disequilibrium report for LDHC (18433853 - 18473605 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LDHC: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for LDHC

    Disorders / Diseases
    for LDHC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LDHC for disorders           About GeneDecksing

    OMIM gene information: 150150    OMIM disorders: --

    20/21 diseases for LDHC (see all 21):    About MalaCards
    lactate dehydrogenase-b deficiency    phototoxic dermatitis    chronic myeloproliferative disease    congenital epilepsy
    varicocele    osteopetrosis    infertility    seminoma
    azoospermia    noma    acute leukemia    lung adenocarcinoma
    gingivitis    nasopharyngitis    adenocarcinoma    pneumonia
    leukemia    malaria    neuronitis    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for LDHC:
    Myocardial infarction     Phototoxic dermatitis

    1 Novoseek disease relationship for LDHC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 6 12438276 (4), 8486524 (1)

    Human Genome Epidemiology (HuGE) Navigator: LDHC (1 document)

    Export disorders for LDHC gene to outside databases

    Publications
    for LDHC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LDHC gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with LDHC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications. (PubMed id 14985855)1, 2, 9 Wang H.... Sha J. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human testicular lactate dehydrogenase-C gene is interrupted by six introns at positions homologous to those of LDH-A (muscle) and LDH-B (heart) genes. (PubMed id 2930531)1, 2 Takano T. and Li S.S.-L. (1989)
    4. Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence. (PubMed id 2440048)1, 2 Millan J.L.... Goldberg E. (1987)
    5. Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer. (PubMed id 12438276)1, 9 Koslowski M....Sahin U. (2002)
    6. Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation. (PubMed id 18930904)1, 9 Tang H. and Goldberg E. (2009)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
    9. Evaluation of multiple serum markers in advanced mela noma. (PubMed id 21858537)1 DA-az-Lagares A....GonzA!lez A. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    External Searches for LDHC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LDHC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3948 HGNC: 6544 AceView: LDHC Ensembl:ENSG00000166796 euGenes: HUgn3948
    ECgene: LDHC Kegg: 3948 H-InvDB: LDHC

    Other Databases showing LDHC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LDHC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LDHC Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LDHC
    Wikipedia http://en.wikipedia.org/wiki/Lactate_dehydrogenase

    Intellectual Property
    for LDHC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LDHC gene:
    Search GeneIP for patents involving LDHC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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