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Aliases for LDHC Gene

Aliases for LDHC Gene

  • Lactate Dehydrogenase C 2 3 5
  • Cancer/Testis Antigen 32 2 3 4
  • LDH Testis Subunit 3 4
  • EC 1.1.1.27 4 61
  • LDH-C 3 4
  • LDH-X 3 4
  • CT32 3 4
  • LDH3 3 4
  • LDHX 3 4
  • Testis Secretory Sperm-Binding Protein Li 234P 3
  • Lactate Dehydrogenase C Variant 1 3
  • Lactate Dehydrogenase C Variant 3 3
  • Lactate Dehydrogenase C Variant 4 3
  • Lactate Dehydrogenase C Variant 5 3
  • L-Lactate Dehydrogenase C Chain 3
  • Lactate Dehydrogenase C4 3
  • EC 1.1.1 61

External Ids for LDHC Gene

Previous GeneCards Identifiers for LDHC Gene

  • GC11P019555
  • GC11P019376
  • GC11P018473
  • GC11P018398
  • GC11P018390
  • GC11P018119

Summaries for LDHC Gene

Entrez Gene Summary for LDHC Gene

  • Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for LDHC Gene

LDHC (Lactate Dehydrogenase C) is a Protein Coding gene. Diseases associated with LDHC include Nuclear Senile Cataract and Phototoxic Dermatitis. Among its related pathways are Metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. GO annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHA.

UniProtKB/Swiss-Prot for LDHC Gene

  • Possible role in sperm motility.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHC Gene

Genomics for LDHC Gene

Regulatory Elements for LDHC Gene

Enhancers for LDHC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F018411 0.6 ENCODE 52.7 0.0 -43 1.2 MAX RAD21 YY1 HIC1 GLIS2 POLR2A PATZ1 PRDM10 ZBTB20 SP3 LDHC SPTY2D1 ENSG00000256006
GH11F018392 0.7 ENCODE 50 -17.6 -17596 5.0 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LDHC LDHA SAAL1 ENSG00000256361 GTF2H1 ENSG00000256006
GH11F018382 1.7 FANTOM5 Ensembl ENCODE 46 -28.1 -28122 3.2 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 FOS SP5 JUNB PPARG LDHC LDHA LDHAL6A SPTY2D1 HPS5 TSG101 MIR3159 GC11P018375
GH11F018587 0.7 ENCODE 20.3 +177.2 177168 4.8 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 DEK SP3 SP5 LDHC SPTY2D1 TSG101 SERGEF GC11M018587 UEVLD
GH11F018489 0.2 ENCODE 19.3 +79.4 79361 4.6 HDAC1 PKNOX1 ESRRA TBL1XR1 TAL1 CCNT2 NCOR1 SCRT2 NR2F6 MTA2 TSG101 LDHC GTF2H1 HPS5 LDHA SPTY2D1-AS1 LOC100129966 YWHABP2 SPTY2D1 ENSG00000256588
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LDHC on UCSC Golden Path with GeneCards custom track

Promoters for LDHC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001767010 94 800 MAX RAD21 YY1 HIC1 GLIS2 POLR2A PATZ1 PRDM10 ZBTB20 SP3

Genomic Location for LDHC Gene

Chromosome:
11
Start:
18,412,306 bp from pter
End:
18,452,058 bp from pter
Size:
39,753 bases
Orientation:
Plus strand

Genomic View for LDHC Gene

Genes around LDHC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDHC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDHC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHC Gene

Proteins for LDHC Gene

  • Protein details for LDHC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07864-LDHC_HUMAN
    Recommended name:
    L-lactate dehydrogenase C chain
    Protein Accession:
    P07864
    Secondary Accessions:
    • D3DQY4
    • Q6GSG8
    • Q7Z7J4

    Protein attributes for LDHC Gene

    Size:
    332 amino acids
    Molecular mass:
    36311 Da
    Quaternary structure:
    • Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity).

neXtProt entry for LDHC Gene

Post-translational modifications for LDHC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LDHC (LDH-C)
  • Santa Cruz Biotechnology (SCBT) Antibodies for LDHC

Domains & Families for LDHC Gene

Suggested Antigen Peptide Sequences for LDHC Gene

Graphical View of Domain Structure for InterPro Entry

P07864

UniProtKB/Swiss-Prot:

LDHC_HUMAN :
  • Belongs to the LDH/MDH superfamily. LDH family.
Family:
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHC: view

No data available for Gene Families for LDHC Gene

Function for LDHC Gene

Molecular function for LDHC Gene

GENATLAS Biochemistry:
lactate dehydrogenase C,glycolysis,energy pathway
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH.
UniProtKB/Swiss-Prot Function:
Possible role in sperm motility.

Enzyme Numbers (IUBMB) for LDHC Gene

Gene Ontology (GO) - Molecular Function for LDHC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004459 L-lactate dehydrogenase activity EXP,IEA 1996957
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with LDHC: view
genes like me logo Genes that share phenotypes with LDHC: view

Animal Models for LDHC Gene

MGI Knock Outs for LDHC:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LDHC Gene

Localization for LDHC Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDHC Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDHC Gene COMPARTMENTS Subcellular localization image for LDHC gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
plasma membrane 2
cytoskeleton 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LDHC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LDHC: view

Pathways & Interactions for LDHC Gene

genes like me logo Genes that share pathways with LDHC: view

Pathways by source for LDHC Gene

UniProtKB/Swiss-Prot P07864-LDHC_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Gene Ontology (GO) - Biological Process for LDHC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006090 pyruvate metabolic process TAS --
GO:0006754 ATP biosynthetic process IEA --
GO:0019244 lactate biosynthetic process from pyruvate IEA --
GO:0019516 lactate oxidation IEA --
genes like me logo Genes that share ontologies with LDHC: view

No data available for SIGNOR curated interactions for LDHC Gene

Drugs & Compounds for LDHC Gene

(9) Drugs for LDHC Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Stiripentol Approved Pharma An LDH inhibitor 8
Pyruvic acid Approved Nutra 0
2-Ketobutyric acid Experimental Pharma 0
NADH Nutra Target 0
isosafrole Pharma A stiripentol analog, a potent LDH inhibitor. 0

(7) Additional Compounds for LDHC Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
  • (RS)-2-Hydroxybutyric acid
  • 2-Hydroxy-Butanoate
  • 2-Hydroxy-Butanoic acid
  • 2-Hydroxy-DL-Butyrate
600-15-7
3-Mercaptolactic acid
  • 3-Mercaptolactate
  • b-Mercaptolactate
  • b-Mercaptolactic acid
  • beta-Mercaptolactate
  • beta-Mercaptolactic acid
2614-83-7
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
2464-23-5
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton

(2) ApexBio Compounds for LDHC Gene

Compound Action Cas Number
Isosafrole A stiripentol analog, a potent LDH inhibitor. 120-58-1
Stiripentol An LDH inhibitor 49763-96-4
genes like me logo Genes that share compounds with LDHC: view

Transcripts for LDHC Gene

Unigene Clusters for LDHC Gene

Lactate dehydrogenase C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDHC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - -

Relevant External Links for LDHC Gene

GeneLoc Exon Structure for
LDHC
ECgene alternative splicing isoforms for
LDHC

Expression for LDHC Gene

mRNA expression in normal human tissues for LDHC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDHC Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for LDHC Gene

This gene is overexpressed in Ovary (19.4), Amniocyte (17.7), Bone marrow mesenchymal stem cell (16.8), and Testis (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LDHC Gene



NURSA nuclear receptor signaling pathways regulating expression of LDHC Gene:

LDHC

SOURCE GeneReport for Unigene cluster for LDHC Gene:

Hs.654377
genes like me logo Genes that share expression patterns with LDHC: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for LDHC Gene

Orthologs for LDHC Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDHC 34 35
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia LDHC 34 35
  • 90.86 (n)
cow
(Bos Taurus)
Mammalia LDHC 34 35
  • 88.96 (n)
mouse
(Mus musculus)
Mammalia Ldhc 34 16 35
  • 79.49 (n)
rat
(Rattus norvegicus)
Mammalia Ldhc 34
  • 77.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia LDHC 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LDHA 35
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 71 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ldha 35
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ImpL3 36 35
  • 58 (a)
CG13334 36 35
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea ldh-1 36 35
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 35
  • 55 (a)
OneToMany
Species where no ortholog for LDHC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LDHC Gene

ENSEMBL:
Gene Tree for LDHC (if available)
TreeFam:
Gene Tree for LDHC (if available)

Paralogs for LDHC Gene

Paralogs for LDHC Gene

genes like me logo Genes that share paralogs with LDHC: view

Variants for LDHC Gene

Sequence variations from dbSNP and Humsavar for LDHC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10610261 -- 18,422,271(+) GAAAT(-/CA)AGGCC intron-variant
rs10766477 -- 18,412,989(+) TCCCT(C/T)CCTTC intron-variant
rs10766478 -- 18,413,169(+) CTCCA(C/T)CTCCC intron-variant
rs10832934 -- 18,414,153(+) TAGAG(C/T)TTATG intron-variant
rs11024647 -- 18,413,974(+) AAGTT(C/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LDHC Gene

Variant ID Type Subtype PubMed ID
esv2671789 CNV deletion 23128226
esv3625500 CNV loss 21293372
nsv467719 CNV gain 19166990
nsv509392 CNV insertion 20534489
nsv510999 OTHER complex 20534489
nsv553633 CNV gain 21841781
nsv553634 CNV gain 21841781

Variation tolerance for LDHC Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDHC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDHC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHC Gene

Disorders for LDHC Gene

MalaCards: The human disease database

(7) MalaCards diseases for LDHC Gene - From: DISEASES

Disorder Aliases PubMed IDs
nuclear senile cataract
  • senile nuclear cataract
phototoxic dermatitis
  • photosensitisation reaction
hermansky-pudlak syndrome 5
  • platelet storage pool deficiency
non-gestational choriocarcinoma
  • choriocarcinoma, non-gestational
dressler's syndrome
  • dressler syndrome
- elite association - COSMIC cancer census association via MalaCards
Search LDHC in MalaCards View complete list of genes associated with diseases

Relevant External Links for LDHC

Genetic Association Database (GAD)
LDHC
Human Genome Epidemiology (HuGE) Navigator
LDHC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDHC
genes like me logo Genes that share disorders with LDHC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LDHC Gene

Publications for LDHC Gene

  1. A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications. (PMID: 14985855) Wang H. … Sha J. (J. Mol. Med. 2004) 3 4 22 64
  2. Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A. (PMID: 21124955) Marzi C. … Gieger C. (PLoS Genet. 2010) 3 46 64
  3. Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation. (PMID: 18930904) Tang H. … Goldberg E. (J. Androl. 2009) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer. (PMID: 12438276) Koslowski M. … Sahin U. (Cancer Res. 2002) 3 22 64

Products for LDHC Gene

Sources for LDHC Gene

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