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LDHC Gene

protein-coding   GIFtS: 63
GCID: GC11P018433

Lactate Dehydrogenase C

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lactate Dehydrogenase C1 2     EC 1.1.1.273 8
Cancer/Testis Antigen 321 2 3     L-Lactate Dehydrogenase C Chain2
LDH32 3 5     Lactate Dehydrogenase C Variant 12
CT322 3     Lactate Dehydrogenase C Variant 32
LDH-C2 3     Lactate Dehydrogenase C Variant 42
LDH-X2 3     Lactate Dehydrogenase C42
LDHX2 3     EC 1.1.18
LDH Testis Subunit2 3     

External Ids:    HGNC: 65441   Entrez Gene: 39482   Ensembl: ENSG000001667967   OMIM: 1501505   UniProtKB: P078643   

Export aliases for LDHC gene to outside databases

Previous GC identifers: GC11P019555 GC11P019376 GC11P018473 GC11P018398 GC11P018390 GC11P018119


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LDHC Gene:
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of
anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript
variants have been detected which differ in the 5' untranslated region. (provided by RefSeq, Jul 2008)

GeneCards Summary for LDHC Gene:
LDHC (lactate dehydrogenase C) is a protein-coding gene. GO annotations related to this gene include L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6B.

UniProtKB/Swiss-Prot: LDHC_HUMAN, P07864
Function: Possible role in sperm motility




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LDHC gene promoter:
         CREB   POU2F1   POU2F1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLDHC promoter sequence
   Search Chromatin IP Primers for LDHC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LDHC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

LDHC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LDHC gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018433:  view genomic region     (about GC identifiers)

Start:
18,433,853 bp from pter      End:
18,473,605 bp from pter
Size:
39,753 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LDHC_HUMAN, P07864 (See protein sequence)
Recommended Name: L-lactate dehydrogenase C chain  
Size: 332 amino acids; 36311 Da
Subunit: Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity)
Secondary accessions: D3DQY4 Q6GSG8 Q7Z7J4

Explore the universe of human proteins at neXtProt for LDHC: NX_P07864

Explore proteomics data for LDHC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LDHC (P07864) (see all 20)
     NLRRVHP  NPVDILT  LDSARFR  IKLKGYT 


    See LDHC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002292.1  NP_059144.1  

    ENSEMBL proteins: 
     ENSP00000437783   ENSP00000379518   ENSP00000280704   ENSP00000438196   ENSP00000441991  
     ENSP00000443414   ENSP00000439555   ENSP00000441478   ENSP00000439060   ENSP00000443997  

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    antibodies-online proteins for LDHC (10 products) 

     
    antibodies-online peptides for LDHC

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR011304 L-lactate_DH
     IPR001236 Lactate/malate_DH_N
     IPR018177 L-lactate_DH_AS
     IPR022383 Lactate/malate_DH_C
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P07864

    ProtoNet protein and cluster: P07864

    2 Blocks protein domains:
    IPB001557 L-lactate dehydrogenase
    IPB011304 L-lactate dehydrogenase


    UniProtKB/Swiss-Prot: LDHC_HUMAN, P07864
    Similarity: Belongs to the LDH/MDH superfamily. LDH family


    Find genes that share domains with LDHC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LDHC_HUMAN, P07864
    Function: Possible role in sperm motility
    Catalytic activity: (S)-lactate + NAD(+) = pyruvate + NADH

         Genatlas biochemistry entry for LDHC:
    lactate dehydrogenase C,glycolysis,energy pathway

         Enzyme Numbers (IUBMB): EC 1.1.1.271 2 EC 1.1.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004459L-lactate dehydrogenase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
         
    Find genes that share ontologies with LDHC           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ldhc):
     endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with LDHC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ldhctm1Erg for LDHC

       genOway: Develop your customized and physiologically relevant rodent model for LDHC

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    GenScript: all cDNA clones in your preferred vector (see all 2): LDHC (NM_002301)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LDHC_HUMAN, P07864: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    cytoskeleton1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0031514motile cilium IEA--

    Find genes that share ontologies with LDHC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LDHC About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis and Gluconeogenesis0.60
    Glycolysis / Gluconeogenesis0.46
    2Metabolism
    Metabolic pathways0.38
    3Sulfur amino acid metabolism
    Cysteine and methionine metabolism0.35
    4Valine, leucine and isoleucine degradation
    Propanoate metabolism0.31
    5Transcription CREM signaling in testis
    Transcription CREM signaling in testis


    Find genes that share SuperPaths with LDHC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for LDHC
        Metabolic States and Circadian Oscillators

    1 Cell Signaling Technology (CST) Pathway for LDHC
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for LDHC
        Transcription CREM signaling in testis

    1 BioSystems Pathway for LDHC
        Glycolysis and Gluconeogenesis



    5 Kegg Pathways  (Kegg details for LDHC):
        Glycolysis / Gluconeogenesis
    Cysteine and methionine metabolism
    Pyruvate metabolism
    Propanoate metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: LDHC_HUMAN, P07864
    Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LDHC
    Interactions:

        GeneGlobe Interaction Network for LDHC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LDHC (ENSP000002807044) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOT1ENSP000003595394STRING: ENSP00000359539
    GOT2ENSP000002452064STRING: ENSP00000245206
    LDHDENSP000003000514STRING: ENSP00000300051
    MPSTENSP000003803184STRING: ENSP00000380318
    PCENSP000003775274STRING: ENSP00000377527
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006090pyruvate metabolic process ----
    GO:0006096glycolytic process IEA--
    GO:0006754ATP biosynthetic process IEA--
    GO:0019244lactate biosynthetic process from pyruvate IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LDHC

    8 HMDB Compounds for LDHC    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxybutyric acid(RS)-2-Hydroxybutyrate (see all 29)600-15-7--
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
    3-Mercaptolactic acid3-mercaptolactate (see all 5)2614-83-7--
    3-Mercaptopyruvic acid3-Mercaptopyruvate (see all 13)2464-23-5--
    L-Lactic acid(+)-Lactate (see all 35)79-33-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    1 DrugBank Compound for LDHC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--182529 2751392 3735252 17139284 17016423

    5 Novoseek inferred chemical compound relationships for LDHC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactate 72.6 30 12438276 (5), 20106611 (1), 1530367 (1), 9364765 (1) (see all 15)
    percoll 43.9 2 8005703 (1), 1879960 (1)
    creatinine 24 8 16140088 (3), 8005703 (1), 9052941 (1)
    testosterone 1.22 2 1530367 (1)
    atp 0 6 8005703 (5), 12438276 (1)



    Find genes that share compounds with LDHC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LDHC gene (2 alternative transcripts): 
    NM_002301.4  NM_017448.3  

    Unigene Cluster for LDHC:

    Lactate dehydrogenase C
    Hs.654377  [show with all ESTs]
    Unigene Representative Sequence: BC064388
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541669(uc001mon.4 uc009yhp.3 uc001moo.4 uc009yhq.3 uc009yhr.3)
    ENST00000396215 ENST00000280704(uc001mom.4) ENST00000545848 ENST00000539369
    ENST00000546146 ENST00000536880 ENST00000537486 ENST00000544105 ENST00000535809

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    hsa-miR-26b* hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidLDHC 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF401094.1 AF401095.1 AF401096.1 AF401097.1 AK058181.1 AY286300.1 BC019249.2 BC064388.1 
    BC090043.1 GU479374.1 HQ386000.1 HQ386001.1 HQ386002.1 HQ386003.1 HQ386004.1 HQ386005.1 
    J02938.1 U13680.1 

    6 DOTS entries:

    DT.95073825  DT.100754652  DT.91711255  DT.100023858  DT.86847104  DT.95246426 

    Selected AceView cDNA sequences (see all 68):

    BC019249 BC064388 AK058181 AA397619 AL048740 AA393114 BI464851 BI559735 
    J02938 BG724108 AF401094 BG773346 AA421141 CD557274 BQ429474 BI831788 
    BI462531 BI825705 BU570598 AF401096 BG717645 BI460557 BI826736 AF401095 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LDHC (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -                                                   
    SP2:                                                                  
    SP3:              -           -                                       
    SP4:              -                                   -               
    SP5:              -           -     -                                 


    ECgene alternative splicing isoforms for LDHC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LDHC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LDHC Expression
    About this image


    LDHC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Mature Sertoli Cells Seminiferous Tubules
             Testis Interstitium
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Thymus (Hematopoietic System)
             Thymus
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)
             Telencephalon
    LDHC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LDHC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654377
        Custom PCR Arrays for LDHC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDHC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LDHC gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ldhc1 , 5 lactate dehydrogenase C1, 5 79.49(n)1
    74.55(a)1
      7 (30.60 cM)5
    168331  NM_013580.41  NP_038608.11 
     468612035 
    chicken
    (Gallus gallus)
    Aves LDHA6
    Gallus gallus lactate dehydrogenase A (LDHA), mRNA...
    72(a)
    1 → many
    5(11936824-11942582) ENSGALG00000006300
    lizard
    (Anolis carolinensis)
    Reptilia --
    L-lactate dehydrogenase
    71(a)
    1 → many
    1(67792747-67811950)
    zebrafish
    (Danio rerio)
    Actinopterygii ldha6
    lactate dehydrogenase A4
    68(a)
    1 → many
    25(25749747-25758098) ENSDARG00000040856
    fruit fly
    (Drosophila melanogaster)
    Insecta ImpL33 glycolysis L-lactate dehydrogenase 58(a)
    (best of 2)
      65A11   --
    worm
    (Caenorhabditis elegans)
    Secernentea ldh-13 L-lactate dehydrogenase 59(a)   II(11725228-11726333)   --


    ENSEMBL Gene Tree for LDHC (if available)
    TreeFam Gene Tree for LDHC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LDHC gene
    LDHAL6B2  UEVLD2  LDHB2  LDHAL6A2  LDHA2  
    5 SIMAP similar genes for LDHC using alignment to 13 protein entries:     LDHC_HUMAN (see all proteins):
    LDHA    LDHB    LDHAL6A    LDHAL6B    UEVLD

    Find genes that share paralogs with LDHC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LDHC (see all 986)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466534031,2
    C--18119788(+) TTTCC-/TTTTTT 2 -- int10--------
    rs1124786061,2
    C--18126892(+) AATGATAGAT/
            
    TAGAC
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs1139411731,2
    C--18129309(+) AAAAA-/ATCCAT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs664969581,2
    --18132778(+) CCACAG/ATTTTT 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1122037851,2
    C--18135064(+) GATTAC/-AGATG 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs726212761,2
    C--18138864(+) CTATGA/CACTTT 2 -- int10--------
    rs113089241,2
    C,F--18144509(+) CTCTC-/A/AAA 
            
    AAAAA
    4 -- int1 cds1 trp32NA CSA 4
    rs1138167731,2
    C--18147693(+) TCTCT-/AAAAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs2000121541,2
    --18150755(+) TCTTT-/CTTTTT 2 -- int10--------
    rs354780861,2
    C--18157333(+) TTTTA-/T/TT  
            
    ACTGG
    2 -- int11NA 2

    HapMap Linkage Disequilibrium report for LDHC (18433853 - 18473605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LDHC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671789CNV Deletion23128226
    nsv509392CNV Insertion20534489
    nsv897027CNV Loss21882294
    nsv467719CNV Gain19166990
    nsv510999CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 150150    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for LDHC:
    Myocardial infarction

    Find genes that share disorders with LDHC           About GenesLikeMe

    1 Novoseek inferred disease relationship for LDHC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 6 12438276 (4), 8486524 (1)

    Genetic Association Database (GAD): LDHC
    Human Genome Epidemiology (HuGE) Navigator: LDHC (1 document)

    Export disorders for LDHC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LDHC gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with LDHC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications. (PubMed id 14985855)1, 2, 9 Wang H.... Sha J. (J. Mol. Med. 2004)
    2. Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A. (PubMed id 21124955)1, 4 Marzi C....Gieger C. (PLoS Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human testicular lactate dehydrogenase-C gene is interrupted by six introns at positions homologous to those of LDH-A (muscle) and LDH-B (heart) genes. (PubMed id 2930531)1, 2 Takano T. and Li S.S.-L. (Biochem. Biophys. Res. Commun. 1989)
    5. Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence. (PubMed id 2440048)1, 2 Millan J.L.... Goldberg E. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    6. Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer. (PubMed id 12438276)1, 9 Koslowski M....Sahin U. (Cancer Res. 2002)
    7. Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation. (PubMed id 18930904)1, 9 Tang H. and Goldberg E. (J. Androl. 2009)
    8. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)1 Vigodner M....Callaway M. (Hum. Reprod. 2013)
    9. Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. (PubMed id 23428871)1 Erazo T....Lizcano J.M. (Mol. Cell. Biol. 2013)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3948 HGNC: 6544 AceView: LDHC Ensembl:ENSG00000166796 euGenes: HUgn3948
    ECgene: LDHC Kegg: 3948 H-InvDB: LDHC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LDHC Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=LDHC[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Lactate_dehydrogenase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LDHC gene:
    Search GeneIP for patents involving LDHC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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