Aliases for LDHB Gene
External Ids for LDHB Gene
Previous GeneCards Identifiers for LDHB Gene
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]
GeneCards Summary for LDHB Gene
LDHB (Lactate Dehydrogenase B) is a Protein Coding gene. Diseases associated with LDHB include glycogen storage disease due to lactate dehydrogenase h-subunit deficiency and lactate dehydrogenase b deficiency. Among its related pathways are Metabolism and Propanoate metabolism. GO annotations related to this gene include identical protein binding and kinase binding. An important paralog of this gene is LDHC.