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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LDHB Gene

protein-coding GIFtS: 67
GCID: GC12M021788

lactate dehydrogenase B

Explore 32 diseases affiliated with
LDHB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lactate Dehydrogenase B¹ ²		LDHBD²
Renal Carcinoma Antigen NY-REN-46² ³		TRG-5²
LDH-B² ³		L-Lactate Dehydrogenase B Chain²
LDH-H² ³		Lactate Dehydrogenase H Chain²
LDH Heart Subunit² ³		EC 1.1.1⁸
EC 1.1.1.27³ ⁸

External Ids:	HGNC: 6541¹	Entrez Gene: 3945²	Ensembl: ENSG00000111716⁷	OMIM: 150100⁵	UniProtKB: P07195³

Export aliases for LDHB gene to outside databases

Previous GC identifers: GC12M022074 GC12M021789 GC12M021688 GC12M021679 GC12M021561

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LDHB:

This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the

glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have

been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same

protein, have been identified. (provided by RefSeq, Mar 2010)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LDHB gene promoter:
GR Sp1 Egr-4 POU2F1 POU2F1a Sox9 GR-alpha Pax-4a TGIF Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LDHB promoter sequence

Search SABiosciences Chromatin IP Primers for LDHB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDHB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.2-p12.1 Ensembl cytogenetic band: 12p12.1 HGNC cytogenetic band: 12p12.2-p12.1

LDHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LDHB gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M021788: view genomic region (about GC identifiers)

Start:	21,788,275 bp from pter	End:	21,910,791 bp from pter
Size:	122,517 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LDHB_HUMAN, P07195 (See protein sequence)

Recommended Name: L-lactate dehydrogenase B chain

Size: 334 amino acids; 36638 Da

Subunit: Homotetramer

Subcellular location: Cytoplasm

2 PDB 3D structures from and Proteopedia for LDHB:

1I0Z (3D)

1T2F (3D)

Explore the universe of human proteins at neXtProt for LDHB: NX_P07195

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07195

4/37 DME Specific Peptides for LDHB (P07195) (see all 37)

WKLSGLP

NPVDILT

VTAGVRQ

KSADTLW

LDHB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001167568.1 NP_002291.1

ENSEMBL proteins:

ENSP00000379386 ENSP00000229319 ENSP00000379385 ENSP00000398015 ENSP00000442680

Reactome Protein details: P07195
Human Recombinant Protein Products for LDHB:

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	ProSpec Recombinant Protein for LDHB
	Uscn Proteins for LDHB

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	TAS	16130169
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--

LDHB for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for LDHB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LDHB for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR001236 Lactate/malate_DH_N

IPR018177 L-lactate_DH_AS

IPR022383 Lactate/malate_DH_C

IPR015955 Lactate_DH/Glyco_Ohase_4_C

IPR011304 L-lactate_DH

Graphical View of Domain Structure for InterPro Entry P07195

ProtoNet protein and cluster: P07195

2 Blocks protein families:

IPB001557 L-lactate dehydrogenase

IPB011304 L-lactate dehydrogenase

UniProtKB/Swiss-Prot: LDHB_HUMAN, P07195

Similarity: Belongs to the LDH/MDH superfamily. LDH family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LDHB_HUMAN, P07195

Catalytic activity: (S)-lactate + NAD(+) = pyruvate + NADH

Genatlas biochemistry entry for LDHB:

lactate dehydrogenase B,glycolysis,energy pathway

Enzyme Numbers (IUBMB): EC 1.1.1.27¹ ² EC 1.1.1²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004457	lactate dehydrogenase activity	--	--
GO:0004459	L-lactate dehydrogenase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0019900	kinase binding	IEA	--
GO:0042802	identical protein binding	IEA	--

LDHB for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for LDHB:

Increased HDAC inhibitor resis

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LDHB

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		hsa-miR-375
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDHB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Glycolysis and gluconeogenesis (short map)

Glycolysis and Gluconeogenesis

0.60

Glycolysis / Gluconeogenesis

0.41

Pyruvate metabolism

Pyruvate metabolism

1.00

Abnormal metabolism in phenylketonuria

Abnormal metabolism in phenylketonuria

1.00

Disease

Disease

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LDHB

Metabolic States and Circadian Oscillators

2 BioSystems Pathways for LDHB

	Glycolysis and Gluconeogenesis
	pyruvate fermentation to lactate

5/6 Reactome Pathways for LDHB (see all 6)

	Pyruvate metabolism
	Pyruvate metabolism and Citric Acid (TCA) cycle
	Metabolism
	Abnormal metabolism in phenylketonuria
	The citric acid (TCA) cycle and respiratory electron transport

5 Kegg Pathways (Kegg details for LDHB):

	Glycolysis / Gluconeogenesis
	Cysteine and methionine metabolism
	Pyruvate metabolism
	Propanoate metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: LDHB_HUMAN, P07195

Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1

LDHB for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LDHB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/84 Interacting proteins for LDHB (P07195^{2, 3} ENSP00000229319⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 84)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TBK1	Q9UHD2²^,³, ENSP00000329967⁴	MINT-49288 I2D: score=2 STRING: ENSP00000329967
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3304522 I2D: score=1 STRING: ENSP00000309503
H2AFX	P16104³, ENSP00000364310⁴	I2D: score=2 STRING: ENSP00000364310
SUMO4	Q6EEV6³, ENSP00000318635⁴	I2D: score=1 STRING: ENSP00000318635
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006089	lactate metabolic process	IEA	--
GO:0006090	pyruvate metabolic process	TAS	--
GO:0006096	glycolysis	IEA	--
GO:0019674	NAD metabolic process	IEA	--
GO:0044262	cellular carbohydrate metabolic process	IEA	--

LDHB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LDHB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LDHB

8 HMDB Compounds for LDHB About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxybutyric acid	(RS)-2-Hydroxybutyrate (see all 29)	600-15-7	--
2-Ketobutyric acid	2-Ketobutanoate (see all 35)	600-18-0	--
3-Mercaptolactic acid	3-mercaptolactate (see all 5)	2614-83-7	--
3-Mercaptopyruvic acid	3-Mercaptopyruvate (see all 13)	2464-23-5	--
L-Lactic acid	(+)-Lactate (see all 35)	79-33-4	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
Pyruvic acid	2-Oxopropanoate (see all 14)	127-17-3	--

4 DrugBank Compounds for LDHB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	4303363 16198644 17139284 12054772 17016423
4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid	--	--	target	--	17139284 17016423
Nicotinamide-Adenine-Dinucleotide	--	53-84-9	target	--	17139284 17016423
Oxamic Acid	--	471-47-6	target	--	17139284 17016423

3 Novoseek chemical compound relationships for LDHB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lactate	75.7	39	2338075 (2), 16890323 (2), 15347626 (2), 16314837 (1) (see all 28)
pyruvate	44.5	3	18789002 (1), 15347626 (1), 18325775 (1)
glucose	0	6	18978174 (1), 15347626 (1), 16193382 (1)

Search CenterWatch for drugs/clinical trials and news about LDHB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LDHB gene (2 alternative transcripts):

NM_001174097.1 NM_002300.6

Unigene Cluster for LDHB:

Lactate dehydrogenase B

Hs.446149 [show with all ESTs]

Unigene Representative Sequence: BG110199

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000542765 ENST00000470985 ENST00000396076(uc001rfd.3) ENST00000350669(uc001rfe.3)

ENST00000396075 ENST00000470280 ENST00000450584 ENST00000539782 ENST00000544151

ENST00000535112

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate LDHB:
		hsa-miR-375
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Additional cDNA sequence:

AK129881.1 AK312328.1 AY189689.1 BC002362.1 BC015122.1 BC022835.1 BC071860.1 BT019764.1

BT019765.1 D28368.1 Y00711.1

24/68 DOTS entries (see all 68):

DT.100702174 DT.87017931 DT.92411683 DT.100672278 DT.92473622 DT.75187926 DT.100702141 DT.95270941

DT.92473652 DT.100702145 DT.121287530 DT.80101777 DT.91797350 DT.92473698 DT.121210295 DT.100702166

DT.99993984 DT.95270842 DT.100702143 DT.121210314 DT.91894242 DT.121210197 DT.121210251 DT.92473669

24/3067 AceView cDNA sequences (see all 3067):

BM915498 BM460486 BF793322 CD251134 BQ684493 BM772678 BQ894808 BU170999

BG110766 AW673902 BM550797 BM456926 AA169294 BM558000 BG029859 BQ219404

AW409602 BQ072152 BE208784 AA858418 CR598156 BI492027 CR600793 CR602943

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for LDHB About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9
SP1:					-		-								-
SP2:							-								-
SP3:					-
SP4:					-		-

ECgene alternative splicing isoforms for LDHB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LDHB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCACAGTT

About this image

LDHB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Thoracic Perivascular Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LDHB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LDHB

SOURCE GeneReport for Unigene cluster: Hs.446149

SABiosciences Custom PCR Arrays for LDHB

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDHB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for LDHB gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LDHB¹	lactate dehydrogenase B	79.98(n) 90.39(a)		373997 NM_204177.1 NP_989508.1
lizard (Anolis carolinensis)	Reptilia	LDHB⁶	--	81(a)	1 ↔ 1	5(6362183-6377265)
African clawed frog (Xenopus laevis)	Amphibia	ldha-B²	lactate dehydrogenase A	80.75(n)		U07179.1
zebrafish (Danio rerio)	Actinopterygii	ldhb²	lactate dehydrogenase B4	74.05(n)		30497 AF067202.1
fruit fly (Drosophila melanogaster)	Insecta	ImpL3³	glycolysis L-lactate dehydrogenase	62(a) (best of 2)		65A11 --
worm (Caenorhabditis elegans)	Secernentea	ldh-1³	L-lactate dehydrogenase	63(a)		II(11725228-11726333) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G17260⁶	L-lactate dehydrogenase	47(a)	1 → many	4(9673991-9675448)
rice (Oryza sativa)	Liliopsida	-- --	lactate/malate dehydrogenase, putative, expressed	43(a) 42(a)	many ↔ many many ↔ many	6(345985-347516) 2(295302-299174)

ENSEMBL Gene Tree for LDHB (if available)
TreeFam Gene Tree for LDHB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LDHB gene

UEVLD² LDHAL6B² LDHA² LDHAL6A² LDHC²

5 SIMAP similar genes for LDHB using alignment to 5 protein entries: LDHB_HUMAN (see all proteins):

LDHAL6A LDHA LDHAL6B LDHC UEVLD

LDHB for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for LDHB
PGOHUM00000248687 PGOHUM00000245444 PGOHUM00000235310 PGOHUM00000241405

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: LDHB_HUMAN, P07195

Polymorphism: Rare LDHB variants result in deficiency of lactate dehydrogenase, a condition with no deleterious effects

on health. LDHB deficiency is of interest to laboratory medicine mainly because it can cause misdiagnosis in those

disorders in which elevation of serum LDH is expected. Lactate dehydrogenase deficiency can probably be considered a

non-disease [MIM:614128]

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1677135^1,2	C,F,H	--	21787920(-)	`TTGAGG/TCTACT`	2	--	ds500¹		15		NS EA NA WA CSA	672
rs111707902^1,2		--	21787941(+)	`CCAGAC/TCAAAC`	2	--	ds500¹		1		CSA	2
rs142338884^1,2		--	21788118(+)	`AAACCA/GTGGCA`	2	--	ds500¹		0	--	--	--	--
rs76055176^1,2		--	21788167(+)	`GGAGTA/GTAGAT`	2	--	ds500¹		0	--	--	--	--
rs74066768^1,2	C	--	21788197(+)	`ATTTAC/TGACGT`	2	--	ds500¹		1		WA	2
rs80333440^1,2	C,F	--	21788200(+)	`TATGAC/TGTGTG`	2	--	ds500¹		1		WA	118
rs181581861^1,2		--	21788257(+)	`AGGAAA/GGAATC`	2	--	ds500¹		0	--	--	--	--
rs150503665^1,2	C,F	--	21788488(+)	`TCTTTT/CAGGTC`	4	/L	syn¹		1		NA	4550
rs15140^1,2	H	--	21788513(-)	`AGATAC/TCCTGT`	4	T I	mis¹ ese³		5		MN NS EA	590
rs185741414^1,2	C	--	21788591(+)	`GGGCAC/TTGAGG`	4	N S	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LDHB (21788275 - 21910791 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LDHB
1 CNV: 4772
Human Gene Mutation Database (HGMD): LDHB

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LDHB for disorders           About GeneDecksing

OMIM gene information: 150100    OMIM disorders: --

20/32 diseases for LDHB (see all 32):    About MalaCards

lactate dehydrogenase-b deficiency renal carcinoma lactate dehydrogenase deficiency carcinoma

chronic myeloproliferative disease panic disorder malignant glioma osteopetrosis

renal cell carcinoma testicular cancer rheumatoid arthritis thymoma

parkinson's disease breast cancer noma medulloblastoma

hepatocellular carcinoma alzheimer's disease colon cancer arthritis

1 disease from the University of Copenhagen DISEASES database for LDHB:

Myocardial infarction

4 Novoseek disease relationships for LDHB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	7.45	5	16547507 (1), 12928234 (1), 16890323 (1), 12406979 (1)
inflammation	0	1	1593572 (1)
breast cancer	0	4	12160330 (1)
tumors	0	4	12160330 (1)

Genetic Association Database (GAD): LDHB
Human Genome Epidemiology (HuGE) Navigator: LDHB (2 documents)

Export disorders for LDHB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LDHB gene, integrated from 9 sources (see all 124):
(articles sorted by number of sources associating them with LDHB)

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Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant. (PubMed id 1587525)^{1, 2, 9} Sudo K.... Toriumi J. (1992)
A missense mutation found in human lactate dehydrogenase-B (H) variant gene. (PubMed id 2334429)^{1, 2, 9} Sudo K.... Li S.S.-L. (1990)
Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder. (PubMed id 12555229)^{1, 4, 9} Philibert R.A....Coryell W.H. (2003)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel missense mutation in human lactate dehydrogenase b-subunit gene. (PubMed id 11509017)^{1, 2} Takatani T.... Okamoto Y. (2001)
Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. (PubMed id 11276087)^{1, 2} Read J.A.... Brady R.L. (2001)
First case of missense mutation (LDH-H:R171P) in exon 4 of the lactate dehydrogenase gene detected in a Japanese patient. (PubMed id 9929983)^{1, 2} Hidaka K.... Iuchi I. (1999)
Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)^{1, 2} Scanlan M.J....Old L.J. (1999)
A novel in-frame deletion mutation in a case of lactate dehydrogenase (LD) H subunit deficiency showing an atypical LD isoenzyme pattern in serum and erythrocytes. (PubMed id 10211631)^{1, 2} Sudo K....Kawano K. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3945	HGNC: 6541	AceView: LDHB	Ensembl:ENSG00000111716	euGenes: HUgn3945
ECgene: LDHB	Kegg: 3945	H-InvDB: LDHB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LDHB	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LDHB
Wikipedia	http://en.wikipedia.org/wiki/Lactate_dehydrogenase
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt109.shtml

Intellectual Property for LDHB gene
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Patent Information for LDHB gene:
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GeneCards and IP:
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lactate dehydrogenase B

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lactate dehydrogenase B

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