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Aliases for LDHB Gene

Aliases for LDHB Gene

  • Lactate Dehydrogenase B 2 3
  • Renal Carcinoma Antigen NY-REN-46 3 4
  • LDH Heart Subunit 3 4
  • EC 4 63
  • LDHBD 3 6
  • LDH-B 3 4
  • LDH-H 3 4
  • Epididymis Secretory Protein Li 281 3
  • L-Lactate Dehydrogenase B Chain 3
  • Lactate Dehydrogenase H Chain 3
  • HEL-S-281 3
  • EC 1.1.1 63
  • TRG-5 3

External Ids for LDHB Gene

Previous GeneCards Identifiers for LDHB Gene

  • GC12M022074
  • GC12M021789
  • GC12M021688
  • GC12M021679
  • GC12M021788
  • GC12M021561

Summaries for LDHB Gene

Entrez Gene Summary for LDHB Gene

  • This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010]

GeneCards Summary for LDHB Gene

LDHB (Lactate Dehydrogenase B) is a Protein Coding gene. Diseases associated with LDHB include lactate dehydrogenase-b deficiency and glycogen storage disease due to lactate dehydrogenase h-subunit deficiency. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include identical protein binding and NAD binding. An important paralog of this gene is LDHC.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHB Gene

Genomics for LDHB Gene

Regulatory Elements for LDHB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LDHB Gene

21,635,341 bp from pter
21,757,857 bp from pter
122,517 bases
Minus strand

Genomic View for LDHB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LDHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHB Gene

Proteins for LDHB Gene

  • Protein details for LDHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    L-lactate dehydrogenase B chain
    Protein Accession:
    Secondary Accessions:

    Protein attributes for LDHB Gene

    334 amino acids
    Molecular mass:
    36638 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for LDHB Gene

neXtProt entry for LDHB Gene

Proteomics data for LDHB Gene at MOPED

Post-translational modifications for LDHB Gene

  • Ubiquitination at Lys7, Lys60, Lys77, Lys82, Lys91, Lys119, Lys233, Lys308, Lys310, Lys319, Lys329, and Lys332
  • Modification sites at PhosphoSitePlus

Other Protein References for LDHB Gene

Antibody Products

Domains for LDHB Gene

Suggested Antigen Peptide Sequences for LDHB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LDH/MDH superfamily. LDH family.
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHB: view

No data available for Gene Families for LDHB Gene

Function for LDHB Gene

Molecular function for LDHB Gene

GENATLAS Biochemistry:
lactate dehydrogenase B,glycolysis,energy pathway
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH

Enzyme Numbers (IUBMB) for LDHB Gene

Gene Ontology (GO) - Molecular Function for LDHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004457 lactate dehydrogenase activity --
GO:0004459 L-lactate dehydrogenase activity IEA --
GO:0005515 protein binding IPI 24725412
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with LDHB: view

Phenotypes for LDHB Gene

GenomeRNAi human phenotypes for LDHB:
genes like me logo Genes that share phenotypes with LDHB: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LDHB

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for LDHB Gene

Localization for LDHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDHB Gene


Subcellular locations from

Jensen Localization Image for LDHB Gene COMPARTMENTS Subcellular localization image for LDHB gene
Compartment Confidence
cytosol 4
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LDHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LDHB: view

Pathways for LDHB Gene

genes like me logo Genes that share pathways with LDHB: view

UniProtKB/Swiss-Prot P07195-LDHB_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1

Gene Ontology (GO) - Biological Process for LDHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006089 lactate metabolic process IEA --
GO:0006090 pyruvate metabolic process TAS --
GO:0006096 glycolytic process --
GO:0019674 NAD metabolic process IEA --
genes like me logo Genes that share ontologies with LDHB: view

Compounds for LDHB Gene

(3) Drugbank Compounds for LDHB Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid
448650 Target experimental
Oxamic Acid
471-47-6 974 Target experimental
  • 1,4-dihydronicotinamide adenine dinucleotide
606-68-8 439153 Target nutraceutical

(8) HMDB Compounds for LDHB Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
2-Ketobutyric acid
  • 2-Ketobutanoate
3-Mercaptolactic acid
  • 3-mercaptolactate
3-Mercaptopyruvic acid
  • 3-Mercaptopyruvate
L-Lactic acid
  • (+)-Lactate

(3) Novoseek inferred chemical compound relationships for LDHB Gene

Compound -log(P) Hits PubMed IDs
lactate 75.7 31
pyruvate 44.5 3
glucose 0 3
genes like me logo Genes that share compounds with LDHB: view

Transcripts for LDHB Gene

Unigene Clusters for LDHB Gene

Lactate dehydrogenase B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LDHB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDHB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for LDHB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LDHB Gene

mRNA expression in normal human tissues for LDHB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDHB Gene

This gene is overexpressed in Heart - Left Ventricle (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LDHB Gene

SOURCE GeneReport for Unigene cluster for LDHB Gene Hs.446149

genes like me logo Genes that share expressions with LDHB: view

Expression partners for LDHB Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LDHB Gene

Orthologs for LDHB Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LDHB 35
  • 92.71 (n)
  • 98.2 (a)
  • 98 (a)
(Canis familiaris)
Mammalia LDHB 35
  • 93.51 (n)
  • 99.4 (a)
-- 36
  • 95 (a)
-- 36
  • 95 (a)
-- 36
  • 97 (a)
-- 36
  • 98 (a)
  • 92 (a)
(Mus musculus)
Mammalia Ldhb 35
  • 86.33 (n)
  • 97.9 (a)
Ldhb 16
Ldhb 36
  • 98 (a)
(Pan troglodytes)
Mammalia LDHB 35
  • 99.8 (n)
  • 99.7 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ldhb 35
  • 86.13 (n)
  • 97.9 (a)
(Monodelphis domestica)
Mammalia LDHB 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia LDHB 36
  • 79 (a)
(Gallus gallus)
Aves LDHB 35
  • 79.98 (n)
  • 90.39 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia LDHB 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ldhb 35
  • 75.65 (n)
  • 84.43 (a)
MGC75741 35
African clawed frog
(Xenopus laevis)
Amphibia ldha-B 35
(Danio rerio)
Actinopterygii ldhb 35
ldhba 35
  • 71.56 (n)
  • 79.94 (a)
ldhba 36
  • 80 (a)
ldhbb 36
  • 68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3984 35
fruit fly
(Drosophila melanogaster)
Insecta CG13334 37
  • 39 (a)
ImpL3 37
  • 62 (a)
CG13334 36
  • 36 (a)
ImpL3 36
  • 62 (a)
(Caenorhabditis elegans)
Secernentea ldh-1 37
  • 63 (a)
ldh-1 36
  • 62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 36
  • 58 (a)
Species with no ortholog for LDHB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LDHB Gene

Gene Tree for LDHB (if available)
Gene Tree for LDHB (if available)

Paralogs for LDHB Gene

Paralogs for LDHB Gene

(5) SIMAP similar genes for LDHB Gene using alignment to 5 proteins: Pseudogenes for LDHB Gene

genes like me logo Genes that share paralogs with LDHB: view

Variants for LDHB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for LDHB Gene

Rare LDHB variants result in deficiency of lactate dehydrogenase, a condition with no deleterious effects on health. LDHB deficiency is of interest to laboratory medicine mainly because it can cause misdiagnosis in those disorders in which elevation of serum LDH is expected. Lactate dehydrogenase deficiency can probably be considered a non-disease [MIM:614128]

Sequence variations from dbSNP and Humsavar for LDHB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4828 -- 21,635,668(-) CTTCC(A/G)TGTAT reference, synonymous-codon
rs15141 -- 21,635,451(-) GTTTG(C/T)TTTGA utr-variant-3-prime
rs153940 -- 21,657,972(+) CAAGT(A/G)TGCAC upstream-variant-2KB
rs187457 -- 21,657,573(-) CGCAG(C/G)GGGGG utr-variant-5-prime, intron-variant
rs759932 -- 21,642,359(+) CAATA(C/T)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LDHB Gene

Variant ID Type Subtype PubMed ID
nsv832349 CNV Gain 17160897
nsv637 CNV Insertion 18451855

Relevant External Links for LDHB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for LDHB Gene

(1) OMIM Diseases for LDHB Gene (150100)

(1) University of Copenhagen DISEASES for LDHB Gene

(4) Novoseek inferred disease relationships for LDHB Gene

Disease -log(P) Hits PubMed IDs
cancer 7.45 4
inflammation 0 1
breast cancer 0 1
tumors 0 1

Relevant External Links for LDHB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LDHB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LDHB Gene

Publications for LDHB Gene

  1. Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder. (PMID: 12555229) Philibert R.A. … Coryell W.H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23 48
  2. A missense mutation found in human lactate dehydrogenase-B (H) variant gene. (PMID: 2334429) Sudo K. … Li S.S.-L. (Biochem. Biophys. Res. Commun. 1990) 3 4 23
  3. Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant. (PMID: 1587525) Sudo K. … Toriumi J. (Hum. Genet. 1992) 3 4 23
  4. Human centrosomal epitope is shared specifically with human lactate dehydrogenase-B isozyme. (PMID: 1371976) Gosti F. … Bornens M. (FEBS Lett. 1992) 3 23
  5. Genetic analyses in homozygous and heterozygous variants of lactate dehydrogenase-B (H) subunit--LD-B Matsumoto I and II (LD-B W323R). (PMID: 10509905) Okumura N. … Katsuyama T. (Clin. Chim. Acta 1999) 3 23

Products for LDHB Gene

Sources for LDHB Gene

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