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Aliases for LDHAL6B Gene

Aliases for LDHAL6B Gene

  • Lactate Dehydrogenase A Like 6B 2 3
  • Lactate Dehydrogenase A-Like 6B 3 5
  • Lactate Dehydrogenase A-Like 6 2 3
  • EC 1.1.1.27 4 63
  • LDHAL6 3 4
  • LDHL 3 4
  • Testicular Tissue Protein Li 105 3
  • EC 1.1.1 63
  • LDH6B 3

External Ids for LDHAL6B Gene

Previous HGNC Symbols for LDHAL6B Gene

  • LDHAL6

Previous GeneCards Identifiers for LDHAL6B Gene

  • GC15P057286
  • GC15P059499
  • GC15P036322

Summaries for LDHAL6B Gene

GeneCards Summary for LDHAL6B Gene

LDHAL6B (Lactate Dehydrogenase A Like 6B) is a Protein Coding gene. Diseases associated with LDHAL6B include hodgkin's lymphoma, lymphocytic depletion. Among its related pathways are Metabolism and Propanoate metabolism. GO annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHC.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHAL6B Gene

Genomics for LDHAL6B Gene

Regulatory Elements for LDHAL6B Gene

Genomic Location for LDHAL6B Gene

Chromosome:
15
Start:
59,206,816 bp from pter
End:
59,208,588 bp from pter
Size:
1,773 bases
Orientation:
Plus strand

Genomic View for LDHAL6B Gene

Genes around LDHAL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDHAL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDHAL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHAL6B Gene

Proteins for LDHAL6B Gene

  • Protein details for LDHAL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYZ2-LDH6B_HUMAN
    Recommended name:
    L-lactate dehydrogenase A-like 6B
    Protein Accession:
    Q9BYZ2
    Secondary Accessions:
    • Q6DUY4
    • Q96LI2

    Protein attributes for LDHAL6B Gene

    Size:
    381 amino acids
    Molecular mass:
    41943 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDHAL6B Gene

Proteomics data for LDHAL6B Gene at MOPED

Post-translational modifications for LDHAL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LDHAL6B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for LDHAL6B Gene

Suggested Antigen Peptide Sequences for LDHAL6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYZ2

UniProtKB/Swiss-Prot:

LDH6B_HUMAN :
  • Belongs to the LDH/MDH superfamily. LDH family.
Family:
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHAL6B: view

No data available for Gene Families for LDHAL6B Gene

Function for LDHAL6B Gene

Molecular function for LDHAL6B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH.

Enzyme Numbers (IUBMB) for LDHAL6B Gene

Gene Ontology (GO) - Molecular Function for LDHAL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004459 L-lactate dehydrogenase activity IEA,TAS --
GO:0005515 protein binding IPI 12107167
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with LDHAL6B: view
genes like me logo Genes that share phenotypes with LDHAL6B: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LDHAL6B Gene

Localization for LDHAL6B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDHAL6B Gene COMPARTMENTS Subcellular localization image for LDHAL6B gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LDHAL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with LDHAL6B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LDHAL6B Gene

Pathways & Interactions for LDHAL6B Gene

genes like me logo Genes that share pathways with LDHAL6B: view

UniProtKB/Swiss-Prot Q9BYZ2-LDH6B_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Gene Ontology (GO) - Biological Process for LDHAL6B Gene

None

No data available for SIGNOR curated interactions for LDHAL6B Gene

Drugs & Compounds for LDHAL6B Gene

(7) Drugs for LDHAL6B Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra 0
2-Ketobutyric acid Experimental Pharma 0
NADH Nutra Target 0
L-lactic acid Pharma Full agonist, Agonist 0
NAD Pharma Full agonist, Agonist 0

(5) Additional Compounds for LDHAL6B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
  • (RS)-2-Hydroxybutyric acid
  • 2-Hydroxy-Butanoate
  • 2-Hydroxy-Butanoic acid
  • 2-Hydroxy-DL-Butyrate
600-15-7
3-Mercaptolactic acid
  • 3-Mercaptolactate
  • b-Mercaptolactate
  • b-Mercaptolactic acid
  • beta-Mercaptolactate
  • beta-Mercaptolactic acid
2614-83-7
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
2464-23-5
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with LDHAL6B: view

Transcripts for LDHAL6B Gene

mRNA/cDNA for LDHAL6B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDHAL6B Gene

Lactate dehydrogenase A-like 6B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LDHAL6B Gene

No ASD Table

Relevant External Links for LDHAL6B Gene

GeneLoc Exon Structure for
LDHAL6B
ECgene alternative splicing isoforms for
LDHAL6B

Expression for LDHAL6B Gene

mRNA expression in normal human tissues for LDHAL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDHAL6B Gene

This gene is overexpressed in Testis (x42.9).

Protein differential expression in normal tissues from HIPED for LDHAL6B Gene

This gene is overexpressed in Lung (22.7), Testis (17.2), Ovary (13.2), and Heart (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LDHAL6B Gene



SOURCE GeneReport for Unigene cluster for LDHAL6B Gene Hs.307052

mRNA Expression by UniProt/SwissProt for LDHAL6B Gene

Q9BYZ2-LDH6B_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with LDHAL6B: view

Protein tissue co-expression partners for LDHAL6B Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LDHAL6B Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHAL6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDHAL6B 36
  • 99 (a)
OneToOne
LDHAL6B 35
  • 99.56 (n)
  • 99.48 (a)
cow
(Bos Taurus)
Mammalia LDHAL6B 35
  • 85.39 (n)
  • 82.68 (a)
dog
(Canis familiaris)
Mammalia LOC484048 35
  • 83.64 (n)
  • 80 (a)
LDHB 36
  • 65 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ldhal6b 16
Ldhal6b 35
  • 76.03 (n)
  • 71.65 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ldhal6b 35
  • 77.25 (n)
  • 74.02 (a)
chicken
(Gallus gallus)
Aves LDHA 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ldha 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13334 36
  • 38 (a)
ManyToMany
ImpL3 36
  • 57 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ldh-1 36
  • 55 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 36
  • 50 (a)
OneToMany
Species with no ortholog for LDHAL6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LDHAL6B Gene

ENSEMBL:
Gene Tree for LDHAL6B (if available)
TreeFam:
Gene Tree for LDHAL6B (if available)

Paralogs for LDHAL6B Gene

Paralogs for LDHAL6B Gene

(5) SIMAP similar genes for LDHAL6B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for LDHAL6B Gene

genes like me logo Genes that share paralogs with LDHAL6B: view

Variants for LDHAL6B Gene

Sequence variations from dbSNP and Humsavar for LDHAL6B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_027936 -
VAR_027937 -
VAR_027938 -
VAR_049757 -

Structural Variations from Database of Genomic Variants (DGV) for LDHAL6B Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
nsv527307 CNV Gain 19592680
nsv833025 CNV Gain 17160897
nsv833027 CNV Gain+Loss 17160897
nsv904272 CNV Loss 21882294

Variation tolerance for LDHAL6B Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.13; 98.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDHAL6B Gene

HapMap Linkage Disequilibrium report
LDHAL6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHAL6B Gene

Disorders for LDHAL6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for LDHAL6B Gene - From: DISEASES

Disorder Aliases PubMed IDs
hodgkin's lymphoma, lymphocytic depletion
  • hodgkin lymphoma, lymphocyte depletion
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LDHAL6B

Genetic Association Database (GAD)
LDHAL6B
Human Genome Epidemiology (HuGE) Navigator
LDHAL6B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDHAL6B
genes like me logo Genes that share disorders with LDHAL6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LDHAL6B Gene

Publications for LDHAL6B Gene

  1. Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis. (PMID: 15870898) Wang H. … Sha J. (Int. J. Mol. Med. 2005) 2 3 23 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3

Products for LDHAL6B Gene

Sources for LDHAL6B Gene

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