LDHAL6B Gene
protein-coding GIFtS: 52
GCID: GC15P059499
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lactate dehydrogenase A-like 6B(Previous name: lactate dehydrogenase A-like 6 )
(Previous symbol: LDHAL6)
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Aliases
for LDHAL6B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Lactate Dehydrogenase A-Like 6B1 2 | | Lactate Dehydrogenase A-Like 61 2 | | LDHAL61 2 3 | | EC 1.1.1.273 8 | | LDHL1 2 3 | | L-Lactate Dehydrogenase A-Like 6B2 | | LDH6B1 2 | | EC 1.1.18 |
Export aliases for LDHAL6B gene to outside databasesPrevious GC identifers: GC15P057286 GC15P036322 |
Summaries
for LDHAL6B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LDHAL6B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LDHAL6B gene promoter:
AhR HFH-3 TBP STAT1 c-Ets-1 Evi-1 Arnt C/EBPalpha FOXI1 TFIID
Other transcription factors
Search SABiosciences Chromatin IP Primers for LDHAL6B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDHAL6B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.2 Ensembl cytogenetic band: 15q22.2 HGNC cytogenetic band: 15q21.3LDHAL6B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P059499: view genomic region
(about GC identifiers)
Start:
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59,499,042 bp from pter |
End:
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59,500,714 bp from pter |
Size:
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1,673 bases |
Orientation:
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plus strand |
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Proteins
for LDHAL6B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LDH6B_HUMAN, Q9BYZ2 (See
protein sequence)Recommended Name: L-lactate dehydrogenase A-like 6B Size: 381 amino acids; 41943 Da
Developmental stage: Higher expression level in adult testis as compared to 6-week-old fetal testis
Caution: It is uncertain whether Met-1 or Met-50 is the initiator
Secondary accessions: Q6DUY4 Q96LI2Explore the universe of human proteins at neXtProt for LDHAL6B: NX_Q9BYZ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BYZ2
4/11 DME Specific Peptides for LDHAL6B (Q9BYZ2) (see all 11)
LDHAL6B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149972.1
ENSEMBL proteins: ENSP00000302393
Human Recombinant Protein Products for LDHAL6B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
LDHAL6B for ontologies About GeneDecksing
LDHAL6B Antibody Products:
Assay Products for LDHAL6B: |
Protein
Domains /
Families
for LDHAL6B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LDHAL6B for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9BYZ2ProtoNet protein and cluster: Q9BYZ2 3 Blocks protein families: IPB000594 UBA/THIF-type NAD/FAD binding fold IPB001557 L-lactate dehydrogenase IPB011304 L-lactate dehydrogenase
UniProtKB/Swiss-Prot: LDH6B_HUMAN, Q9BYZ2Similarity: Belongs to the LDH/MDH superfamily. LDH family |
Function
for LDHAL6B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: LDH6B_HUMAN, Q9BYZ2Catalytic activity: (S)-lactate + NAD(+) = pyruvate + NADH Enzyme Numbers (IUBMB): EC 1.1.1.271 2 EC 1.1.12
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
LDHAL6B for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for LDHAL6B:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LDHAL6B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LDHAL6B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for LDHAL6B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDHAL6B |
|
Pathways & Interactions
for LDHAL6B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glycolysis and gluconeogenesis (short map) | | | 2 | pyruvate fermentation to lactate | | | 3 | Pyruvate metabolism | | | 4 | Metabolism | | | 5 | Sulfur amino acid metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for LDHAL6B
5 
Kegg Pathways (Kegg details for LDHAL6B):
UniProtKB/Swiss-Prot: LDH6B_HUMAN, Q9BYZ2Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1
LDHAL6B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LDHAL6B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for LDHAL6B (Q9BYZ21, 3 ENSP000003023934) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006096 | glycolysis |
IEA | -- | | GO:0044262 | cellular carbohydrate metabolic process |
IEA | -- |
LDHAL6B for ontologies About GeneDecksing
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Drugs & Compounds
for LDHAL6B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
LDHAL6B for compounds About GeneDecksing
 Browse Tocris compounds for LDHAL6B
8 HMDB Compounds for LDHAL6B About this table
1 DrugBank Compound for LDHAL6B About this table
3 Novoseek chemical compound relationships for LDHAL6B gene About this table
Search CenterWatch for drugs/clinical trials and news about LDHAL6B / LDH6B
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Transcripts
for LDHAL6B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LDHAL6B gene: NM_033195.2 Unigene Cluster for LDHAL6B: Lactate dehydrogenase A-like 6B Hs.307052 [show with all ESTs]Unigene Representative Sequence: NM_0331951 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000307144(uc002agb.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LDHAL6B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LDHAL6B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LDHAL6B (NM_033195) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LDHAL6B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDHAL6B |
Additional cDNA sequence: AK058192.1 AK312777.1 AY009108.1 AY642121.1 BC022034.1 1 DOTS entry: DT.403779 24/26 AceView cDNA sequences (see all 26): NM_033195 AY009108 AY642121 BU852250 BQ435491 BC022034 BQ435512 BG773393 BI826021 BI830589 BI461357 BU570083 BG718803 BU853569 AK058192 BI559890 CD557706 BG718663 BG717736 BG722528 BM172234 BU561631 AA398148 BI461518
GeneLoc Exon Structure
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Expression
for LDHAL6B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LDHAL6B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATATATAT
About this image
See LDHAL6B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LDHAL6B
SOURCE GeneReport for Unigene cluster: Hs.307052
UniProtKB/Swiss-Prot: LDH6B_HUMAN, Q9BYZ2Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for LDHAL6B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LDHAL6B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LDHAL6B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDHAL6B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDHAL6B |
Orthologs
for LDHAL6B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for LDHAL6B gene from 8/20 species (see all 20) About this table
ENSEMBL Gene Tree for LDHAL6B (if available)
TreeFam Gene Tree for LDHAL6B (if available) |
Paralogs
for LDHAL6B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LDHAL6B gene
- UEVLD2 LDHB2 LDHAL6A2 LDHA2 LDHC2
5 SIMAP similar genes for LDHAL6B using alignment to 1 protein entry: LDH6B_HUMAN:LDHAL6A LDHA LDHB LDHC UEVLD
LDHAL6B for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for LDHAL6B
PGOHUM00000242388 PGOHUM00000239825 PGOHUM00000245586 PGOHUM00000243426
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Genomic Variants
for LDHAL6B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LDHAL6B
1 CNV: 4903 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LDHAL6B |
|
Disorders
/ Diseases
for LDHAL6B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LDHAL6B for disorders About GeneDecksing
4  diseases for LDHAL6B: About MalaCardslactate dehydrogenase-b deficiency trachoma pneumonia malaria
1 disease from the University of Copenhagen DISEASES database for LDHAL6B:Myocardial infarction Human Genome Epidemiology (HuGE) Navigator: LDHAL6B (2 documents)
Export disorders for LDHAL6B gene to outside databases
|
Publications
for LDHAL6B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LDHAL6B gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with LDHAL6B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis. (PubMed id 15870898)1, 3, 9 Wang H....Sha J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
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External Searches for LDHAL6B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing LDHAL6B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LDHAL6B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LDHAL6B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LDHAL6B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LDHAL6B gene:
Search GeneIP for patents involving LDHAL6B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LDHAL6B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LDHAL6B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LDHAL6B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LDHAL6B | | | OriGene Protein Over-expression Lysate for LDHAL6B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LDHAL6B | | OriGene 3'-UTR Clone for LDHAL6B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LDHAL6B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LDHAL6B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LDHAL6B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LDHAL6B | | OriGene Custom Protein Services for LDHAL6B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LDHAL6B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LDHAL6B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDHAL6B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LDHAL6B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDHAL6B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LDHAL6B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDHAL6B |
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