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Aliases for LDHAL6B Gene

Aliases for LDHAL6B Gene

  • Lactate Dehydrogenase A Like 6B 2 3 5
  • Lactate Dehydrogenase A-Like 6 2 3
  • EC 4 61
  • LDHAL6 3 4
  • LDHL 3 4
  • L-Lactate Dehydrogenase A-Like 6B 3
  • Testicular Tissue Protein Li 105 3
  • EC 1.1.1 61
  • LDH6B 3

External Ids for LDHAL6B Gene

Previous HGNC Symbols for LDHAL6B Gene

  • LDHAL6

Previous GeneCards Identifiers for LDHAL6B Gene

  • GC15P057286
  • GC15P059499
  • GC15P036322

Summaries for LDHAL6B Gene

GeneCards Summary for LDHAL6B Gene

LDHAL6B (Lactate Dehydrogenase A Like 6B) is a Protein Coding gene. Diseases associated with LDHAL6B include Hodgkin's Lymphoma, Lymphocytic Depletion. Among its related pathways are Metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. GO annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHAL6B Gene

Genomics for LDHAL6B Gene

Regulatory Elements for LDHAL6B Gene

Enhancers for LDHAL6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F059173 1.4 FANTOM5 Ensembl ENCODE 32.4 -30.5 -30495 5.2 CTCF ZNF146 ZNF654 PKNOX1 SIN3A RAD21 TEAD3 POLR2A PBX2 CEBPA LDHAL6B FAM81A MYO1E RNF111 ADAM10 MIR2116
GH15F059199 0.6 FANTOM5 ENCODE 32 -6.6 -6550 2.2 INSM2 KLF17 SIN3A ZNF2 RAD21 SLC30A9 ZNF366 ZNF143 FOS DEK LDHAL6B BNIP2 RNF111 ADAM10 MIR2116
GH15F059180 1.4 Ensembl ENCODE 30.2 -25.7 -25692 1.0 HDAC1 TAL1 ZEB2 CEBPG NR2F2 ARID1B FOSL1 ATF3 IKZF1 MAFK LDHAL6B RNU4-80P MIR2116
GH15F059190 1.4 Ensembl ENCODE 22.1 -15.0 -14968 2.9 JUN CHD4 BMI1 EED ZNF207 ETV6 FOS CREM MAFK MTA2 LDHAL6B MIR2116 FAM81A
GH15F059168 1.4 FANTOM5 Ensembl ENCODE 15.7 -36.7 -36749 3.8 ZNF146 SAP130 JUN ZNF175 NFXL1 ZIC2 TEAD3 ZNF316 FOS NR2F6 LDHAL6B RNF111 ADAM10 SLTM MIR2116 ENSG00000259732
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LDHAL6B on UCSC Golden Path with GeneCards custom track

Genomic Location for LDHAL6B Gene

59,206,816 bp from pter
59,208,588 bp from pter
1,773 bases
Plus strand

Genomic View for LDHAL6B Gene

Genes around LDHAL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDHAL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDHAL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHAL6B Gene

Proteins for LDHAL6B Gene

  • Protein details for LDHAL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    L-lactate dehydrogenase A-like 6B
    Protein Accession:
    Secondary Accessions:
    • Q6DUY4
    • Q96LI2

    Protein attributes for LDHAL6B Gene

    381 amino acids
    Molecular mass:
    41943 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDHAL6B Gene

Selected DME Specific Peptides for LDHAL6B Gene


Post-translational modifications for LDHAL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LDHAL6B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LDHAL6B Gene

Suggested Antigen Peptide Sequences for LDHAL6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LDH/MDH superfamily. LDH family.
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHAL6B: view

No data available for Gene Families for LDHAL6B Gene

Function for LDHAL6B Gene

Molecular function for LDHAL6B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH.

Enzyme Numbers (IUBMB) for LDHAL6B Gene

Gene Ontology (GO) - Molecular Function for LDHAL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004459 L-lactate dehydrogenase activity TAS --
GO:0005515 protein binding IPI 12107167
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with LDHAL6B: view
genes like me logo Genes that share phenotypes with LDHAL6B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LDHAL6B Gene

Localization for LDHAL6B Gene

Subcellular locations from

Jensen Localization Image for LDHAL6B Gene COMPARTMENTS Subcellular localization image for LDHAL6B gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LDHAL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with LDHAL6B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LDHAL6B Gene

Pathways & Interactions for LDHAL6B Gene

genes like me logo Genes that share pathways with LDHAL6B: view

UniProtKB/Swiss-Prot Q9BYZ2-LDH6B_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Gene Ontology (GO) - Biological Process for LDHAL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006090 pyruvate metabolic process TAS --
GO:0019752 carboxylic acid metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LDHAL6B: view

No data available for SIGNOR curated interactions for LDHAL6B Gene

Drugs & Compounds for LDHAL6B Gene

(7) Drugs for LDHAL6B Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra 0
2-Ketobutyric acid Experimental Pharma 0
NADH Nutra Target 0
L-lactic acid Pharma Full agonist, Agonist 0
NAD Pharma Full agonist, Agonist 0

(5) Additional Compounds for LDHAL6B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
  • (RS)-2-Hydroxybutyric acid
  • 2-Hydroxy-Butanoate
  • 2-Hydroxy-Butanoic acid
  • 2-Hydroxy-DL-Butyrate
3-Mercaptolactic acid
  • 3-Mercaptolactate
  • b-Mercaptolactate
  • b-Mercaptolactic acid
  • beta-Mercaptolactate
  • beta-Mercaptolactic acid
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with LDHAL6B: view

Transcripts for LDHAL6B Gene

mRNA/cDNA for LDHAL6B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDHAL6B Gene

Lactate dehydrogenase A-like 6B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDHAL6B Gene

No ASD Table

Relevant External Links for LDHAL6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LDHAL6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LDHAL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LDHAL6B Gene

This gene is overexpressed in Testis (x42.9).

Protein differential expression in normal tissues from HIPED for LDHAL6B Gene

This gene is overexpressed in Lung (22.7), Testis (17.2), Ovary (13.2), and Heart (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LDHAL6B Gene

Protein tissue co-expression partners for LDHAL6B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LDHAL6B Gene:


SOURCE GeneReport for Unigene cluster for LDHAL6B Gene:


mRNA Expression by UniProt/SwissProt for LDHAL6B Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with LDHAL6B: view

Primer Products

Orthologs for LDHAL6B Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHAL6B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LDHAL6B 34 35
  • 99.56 (n)
(Bos Taurus)
Mammalia LDHAL6B 34
  • 85.39 (n)
(Canis familiaris)
Mammalia LOC484048 34
  • 83.64 (n)
  • 65 (a)
(Rattus norvegicus)
Mammalia Ldhal6b 34
  • 77.25 (n)
(Mus musculus)
Mammalia Ldhal6b 34 16
  • 76.03 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
-- 35
  • 61 (a)
(Gallus gallus)
Aves LDHA 35
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
(Danio rerio)
Actinopterygii ldha 35
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta ImpL3 35
  • 57 (a)
CG13334 35
  • 38 (a)
(Caenorhabditis elegans)
Secernentea ldh-1 35
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 35
  • 50 (a)
Species where no ortholog for LDHAL6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LDHAL6B Gene

Gene Tree for LDHAL6B (if available)
Gene Tree for LDHAL6B (if available)

Paralogs for LDHAL6B Gene

Paralogs for LDHAL6B Gene

(5) SIMAP similar genes for LDHAL6B Gene using alignment to 1 proteins: Pseudogenes for LDHAL6B Gene

genes like me logo Genes that share paralogs with LDHAL6B: view

Variants for LDHAL6B Gene

Sequence variations from dbSNP and Humsavar for LDHAL6B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs111497945 -- 59,208,539(+) CTTTT(C/G)TTTTG intron-variant, utr-variant-3-prime
rs111978924 -- 59,208,260(+) TGGAC(G/T)ATACT intron-variant, utr-variant-3-prime
rs112372710 -- 59,207,726(+) AAGGA(A/C/T)CTGAA intron-variant, reference, synonymous-codon, missense
rs112956314 -- 59,207,551(+) TCCCA(A/G)AAACC intron-variant, reference, missense
rs113206163 -- 59,208,579(+) GTTGA(A/T)TCAAT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LDHAL6B Gene

Variant ID Type Subtype PubMed ID
nsv527307 CNV gain 19592680
nsv7266 OTHER inversion 18451855
nsv833025 CNV gain 17160897
nsv833027 CNV gain+loss 17160897
nsv974584 CNV duplication 23825009

Variation tolerance for LDHAL6B Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.13; 98.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDHAL6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHAL6B Gene

Disorders for LDHAL6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for LDHAL6B Gene - From: DISEASES

Disorder Aliases PubMed IDs
hodgkin's lymphoma, lymphocytic depletion
  • hodgkin lymphoma, lymphocyte depletion
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LDHAL6B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LDHAL6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LDHAL6B Gene

Publications for LDHAL6B Gene

  1. Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis. (PMID: 15870898) Wang H. … Sha J. (Int. J. Mol. Med. 2005) 2 3 22 64
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for LDHAL6B Gene

Sources for LDHAL6B Gene

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