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Aliases for LDHAL6A Gene

Aliases for LDHAL6A Gene

  • Lactate Dehydrogenase A-Like 6A 2 3
  • EC 1.1.1.27 4 63
  • L-Lactate Dehydrogenase A-Like 6A 3
  • EC 1.1.1 63
  • LDH6A 3
  • LDHL2 4

External Ids for LDHAL6A Gene

Previous GeneCards Identifiers for LDHAL6A Gene

  • GC11P018163

Summaries for LDHAL6A Gene

GeneCards Summary for LDHAL6A Gene

LDHAL6A (Lactate Dehydrogenase A-Like 6A) is a Protein Coding gene. Among its related pathways are Metabolism and Sulfur amino acid metabolism. GO annotations related to this gene include L-lactate dehydrogenase activity. An important paralog of this gene is LDHC.

UniProtKB/Swiss-Prot for LDHAL6A Gene

  • Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHAL6A Gene

Genomics for LDHAL6A Gene

Regulatory Elements for LDHAL6A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LDHAL6A Gene

Start:
18,455,824 bp from pter
End:
18,479,600 bp from pter
Size:
23,777 bases
Orientation:
Plus strand

Genomic View for LDHAL6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LDHAL6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHAL6A Gene

Proteins for LDHAL6A Gene

  • Protein details for LDHAL6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMR3-LDH6A_HUMAN
    Recommended name:
    L-lactate dehydrogenase A-like 6A
    Protein Accession:
    Q6ZMR3
    Secondary Accessions:
    • D3DQY5

    Protein attributes for LDHAL6A Gene

    Size:
    332 amino acids
    Molecular mass:
    36507 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDHAL6A Gene

Proteomics data for LDHAL6A Gene at MOPED

Post-translational modifications for LDHAL6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LDHAL6A Gene

Domains for LDHAL6A Gene

Suggested Antigen Peptide Sequences for LDHAL6A Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMR3

UniProtKB/Swiss-Prot:

LDH6A_HUMAN :
  • Q6ZMR3
Family:
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHAL6A: view

No data available for Gene Families for LDHAL6A Gene

Function for LDHAL6A Gene

Molecular function for LDHAL6A Gene

UniProtKB/Swiss-Prot CatalyticActivity: (S)-lactate + NAD(+) = pyruvate + NADH
UniProtKB/Swiss-Prot Function: Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.

Enzyme Numbers (IUBMB) for LDHAL6A Gene

Gene Ontology (GO) - Molecular Function for LDHAL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004459 L-lactate dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
genes like me logo Genes that share ontologies with LDHAL6A: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LDHAL6A Gene

Localization for LDHAL6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDHAL6A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LDHAL6A Gene COMPARTMENTS Subcellular localization image for LDHAL6A gene
Compartment Confidence
cytosol 3
mitochondrion 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LDHAL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with LDHAL6A: view

Pathways for LDHAL6A Gene

genes like me logo Genes that share pathways with LDHAL6A: view

Pathways by source for LDHAL6A Gene

UniProtKB/Swiss-Prot Q6ZMR3-LDH6A_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1

Interacting Proteins for LDHAL6A Gene

Gene Ontology (GO) - Biological Process for LDHAL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0019752 carboxylic acid metabolic process IEA --
GO:0044262 cellular carbohydrate metabolic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LDHAL6A: view

Compounds for LDHAL6A Gene

(8) HMDB Compounds for LDHAL6A Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
600-15-7
2-Ketobutyric acid
  • 2-Ketobutanoate
600-18-0
3-Mercaptolactic acid
  • 3-mercaptolactate
2614-83-7
3-Mercaptopyruvic acid
  • 3-Mercaptopyruvate
2464-23-5
L-Lactic acid
  • (+)-Lactate
79-33-4

(1) Drugbank Compounds for LDHAL6A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with LDHAL6A: view

Transcripts for LDHAL6A Gene

mRNA/cDNA for LDHAL6A Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDHAL6A Gene

Lactate dehydrogenase A-like 6A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LDHAL6A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDHAL6A Gene

No ASD Table

Relevant External Links for LDHAL6A Gene

GeneLoc Exon Structure for
LDHAL6A
ECgene alternative splicing isoforms for
LDHAL6A

Expression for LDHAL6A Gene

mRNA expression in normal human tissues for LDHAL6A Gene

mRNA differential expression in normal tissues according to GTEx for LDHAL6A Gene

This gene is overexpressed in Testis (22.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LDHAL6A Gene

SOURCE GeneReport for Unigene cluster for LDHAL6A Gene Hs.668877

mRNA Expression by UniProt/SwissProt for LDHAL6A Gene

Q6ZMR3-LDH6A_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with LDHAL6A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LDHAL6A Gene

Orthologs for LDHAL6A Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHAL6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDHAL6A 35
  • 99.9 (n)
  • 100 (a)
LDHAL6A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LDHA 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ldha 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13334 36
  • 35 (a)
ManyToMany
ImpL3 36
  • 57 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ldh-1 36
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 36
  • 49 (a)
OneToMany
Species with no ortholog for LDHAL6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LDHAL6A Gene

ENSEMBL:
Gene Tree for LDHAL6A (if available)
TreeFam:
Gene Tree for LDHAL6A (if available)

Paralogs for LDHAL6A Gene

Paralogs for LDHAL6A Gene

Selected SIMAP similar genes for LDHAL6A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LDHAL6A: view

Variants for LDHAL6A Gene

Sequence variations from dbSNP and Humsavar for LDHAL6A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs181713 -- 18,462,099(-) acttt(C/T)tcagg intron-variant
rs189826 -- 18,462,066(-) gcctt(C/T)tgggt intron-variant
rs2056780 -- 18,466,242(-) TAAAT(G/T)CTTTT intron-variant
rs2063015 -- 18,465,441(-) AATAA(A/T)AAAAA intron-variant
rs2643864 -- 18,459,404(-) caaag(C/G)cccga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LDHAL6A Gene

Variant ID Type Subtype PubMed ID
nsv509392 CNV Insertion 20534489
nsv510999 CNV Complex 20534489
nsv897027 CNV Loss 21882294
nsv467719 CNV Gain 19166990
esv2744170 CNV Deletion 23290073
esv2744171 CNV Deletion 23290073
esv2744172 CNV Deletion 23290073

Relevant External Links for LDHAL6A Gene

HapMap Linkage Disequilibrium report
LDHAL6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHAL6A Gene

Disorders for LDHAL6A Gene

(1) University of Copenhagen DISEASES for LDHAL6A Gene

genes like me logo Genes that share disorders with LDHAL6A: view

No data available for UniProtKB/Swiss-Prot for LDHAL6A Gene

Publications for LDHAL6A Gene

  1. Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA). (PMID: 18351441) Chen X. … Yu L. (Mol. Biol. Rep. 2009) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. (PMID: 17500595) Kaltenbach L.S. … Hughes R.E. (PLoS Genet. 2007) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for LDHAL6A Gene

Sources for LDHAL6A Gene

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