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LDHAL6A Gene

protein-coding   GIFtS: 49
GCID: GC11P018434

Lactate Dehydrogenase A-Like 6A

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lactate Dehydrogenase A-Like 6A1 2
EC 1.1.1.273 8
LDH6A2
L-Lactate Dehydrogenase A-Like 6A2
LDHL23
EC 1.1.18

External Ids:    HGNC: 283351   Entrez Gene: 1602872   Ensembl: ENSG000001668007   UniProtKB: Q6ZMR33   

Export aliases for LDHAL6A gene to outside databases

Previous GC identifer: GC11P018163


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LDHAL6A Gene:
LDHAL6A (lactate dehydrogenase A-like 6A) is a protein-coding gene. Diseases associated with LDHAL6A include lactate dehydrogenase b deficiency, and pneumonia. GO annotations related to this gene include L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6B.

UniProtKB/Swiss-Prot: LDH6A_HUMAN, Q6ZMR3
Function: Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN,
when overexpressed




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LDHAL6A gene promoter:
         HOXA9   HOXA9B   GATA-3   CUTL1   GATA-1   GATA-2   E47   Meis-1b   Hand1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLDHAL6A promoter sequence
   Search Chromatin IP Primers for LDHAL6A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LDHAL6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

LDHAL6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LDHAL6A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018434:  view genomic region     (about GC identifiers)

Start:
18,477,371 bp from pter      End:
18,501,147 bp from pter
Size:
23,777 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LDH6A_HUMAN, Q6ZMR3 (See protein sequence)
Recommended Name: L-lactate dehydrogenase A-like 6A  
Size: 332 amino acids; 36507 Da
Secondary accessions: D3DQY5

Explore the universe of human proteins at neXtProt for LDHAL6A: NX_Q6ZMR3

Explore proteomics data for LDHAL6A at MOPED

Selected DME Specific Peptides for LDHAL6A (Q6ZMR3) (see all 15)
 NLRRVHP  NPVDILT  ACAISIL  LDSARFR 


See LDHAL6A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001137543.1  NP_659409.2  

ENSEMBL proteins: 
 ENSP00000379516   ENSP00000280706  

LDHAL6A Human Recombinant Protein Products:

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ThermoFisher Antibodies for LDHAL6A
LSBio Antibodies in human, mouse, rat for LDHAL6A

LDHAL6A Assay Products:

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Cloud-Clone Corp. ELISAs for LDHAL6A
Cloud-Clone Corp. CLIAs for LDHAL6A


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 7):
 IPR011304 L-lactate_DH
 IPR001236 Lactate/malate_DH_N
 IPR018177 L-lactate_DH_AS
 IPR022383 Lactate/malate_DH_C
 IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q6ZMR3

ProtoNet protein and cluster: Q6ZMR3

3 Blocks protein domains:
IPB000594 UBA/THIF-type NAD/FAD binding fold
IPB001557 L-lactate dehydrogenase
IPB011304 L-lactate dehydrogenase


UniProtKB/Swiss-Prot: LDH6A_HUMAN, Q6ZMR3
Similarity: Belongs to the LDH/MDH superfamily. LDH family


LDHAL6A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LDH6A_HUMAN, Q6ZMR3
Function: Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN,
when overexpressed
Catalytic activity: (S)-lactate + NAD(+) = pyruvate + NADH

     Enzyme Numbers (IUBMB): EC 1.1.1.271 2 EC 1.1.12

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004459L-lactate dehydrogenase activity IEA--
GO:0016491oxidoreductase activity ----
GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
     
LDHAL6A for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LDHAL6A
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LDHAL6A

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LDHAL6A
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LDHAL6A

miRNA
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Block miRNA regulation of human, mouse, rat LDHAL6A using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate LDHAL6A:
hsa-miR-1258 hsa-miR-551b* hsa-miR-331-5p hsa-miR-606
SwitchGear 3'UTR luciferase reporter plasmidLDHAL6A 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for LDHAL6A
Predesigned siRNA for gene silencing in human, mouse, rat LDHAL6A

Gene Editing
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OriGene clones in human, mouse for LDHAL6A (see all 12)
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GenScript: all cDNA clones in your preferred vector (see all 2): LDHAL6A (NM_001144071)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LDHAL6A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDHAL6A

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDHAL6A


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LDH6A_HUMAN, Q6ZMR3: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
mitochondrion2
cytoskeleton1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--

LDHAL6A for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for LDHAL6A About                                                                                                See pathways by source

SuperPathContained pathways About
1Valine, leucine and isoleucine degradation
Propanoate metabolism0.31
pyruvate fermentation to lactate0.00
2Glycolysis and gluconeogenesis short map
Glycolysis / Gluconeogenesis0.46
3Metabolism
Metabolic pathways0.38
4Sulfur amino acid metabolism
Cysteine and methionine metabolism0.35
5Pyruvate metabolism
Pyruvate metabolism

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for LDHAL6A
    pyruvate fermentation to lactate


5 Kegg Pathways  (Kegg details for LDHAL6A):
    Glycolysis / Gluconeogenesis
Cysteine and methionine metabolism
Pyruvate metabolism
Propanoate metabolism
Metabolic pathways

UniProtKB/Swiss-Prot: LDH6A_HUMAN, Q6ZMR3
Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1


LDHAL6A for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LDHAL6A
Interactions:

    Search GeneGlobe Interaction Network for LDHAL6A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for LDHAL6A (ENSP000002807064) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

InteractantInteraction Details
GeneCardExternal ID(s)
GOT1ENSP000003595394STRING: ENSP00000359539
GOT2ENSP000002452064STRING: ENSP00000245206
LDHDENSP000003000514STRING: ENSP00000300051
MPSTENSP000003803184STRING: ENSP00000380318
PCENSP000003775274STRING: ENSP00000377527
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005975carbohydrate metabolic process ----
GO:0006096glycolytic process IEA--
GO:0044262cellular carbohydrate metabolic process IEA--
GO:0055114oxidation-reduction process ----

LDHAL6A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LDHAL6A (LDH6A)

8 HMDB Compounds for LDHAL6A    About this table
CompoundSynonyms CAS #PubMed Ids
2-Hydroxybutyric acid(RS)-2-Hydroxybutyrate (see all 29)600-15-7--
2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
3-Mercaptolactic acid3-mercaptolactate (see all 5)2614-83-7--
3-Mercaptopyruvic acid3-Mercaptopyruvate (see all 13)2464-23-5--
L-Lactic acid(+)-Lactate (see all 35)79-33-4--
NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

1 DrugBank Compound for LDHAL6A    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for LDHAL6A gene (2 alternative transcripts): 
NM_001144071.1  NM_144972.4  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000396213 ENST00000280706(uc001mop.1 uc001moq.2)
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat LDHAL6A using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate LDHAL6A:
hsa-miR-1258 hsa-miR-551b* hsa-miR-331-5p hsa-miR-606
SwitchGear 3'UTR luciferase reporter plasmidLDHAL6A 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for LDHAL6A
Predesigned siRNA for gene silencing in human, mouse, rat LDHAL6A
Clone
Products:
     
OriGene clones in human, mouse for LDHAL6A (see all 12)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): LDHAL6A (NM_001144071)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LDHAL6A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LDHAL6A
Primer
Products:
    
OriGene qPCR primer pairs and template standards for LDHAL6A
OriGene qSTAR qPCR primer pairs in human, mouse for LDHAL6A
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LDHAL6A
  QuantiTect SYBR Green Assays in human, mouse, rat LDHAL6A
  QuantiFast Probe-based Assays in human, mouse, rat LDHAL6A

10 AceView cDNA sequences:

AY581313 AL518086 BX113940 AI652318 NM_144972 AK131523 BC014340 BE972242 
BX458075 AL518085 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LDHAL6A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCGACTCAAG
LDHAL6A Expression
About this image

LDHAL6A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LDHAL6A Protein Expression

Genevestigator expression for LDHAL6A

UniProtKB/Swiss-Prot: LDH6A_HUMAN, Q6ZMR3
Tissue specificity: Testis-specific

    Custom PCR Arrays for LDHAL6A
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QuantiFast Probe-based Assays in human, mouse, rat LDHAL6A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LDHAL6A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LDHAL6A gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
L-lactate dehydrogenase
59(a)
many ↔ many
35(8404560-8405574)
chicken
(Gallus gallus)
Aves LDHA6
Gallus gallus lactate dehydrogenase A (LDHA), mRNA...
69(a)
1 → many
5(11936824-11942582) ENSGALG00000006300
lizard
(Anolis carolinensis)
Reptilia --
L-lactate dehydrogenase
69(a)
1 → many
1(67792747-67811950)
zebrafish
(Danio rerio)
Actinopterygii ldha6
lactate dehydrogenase A4
67(a)
1 → many
25(25749747-25758098) ENSDARG00000040856
fruit fly
(Drosophila melanogaster)
Insecta ImpL36
CG133346
--
57(a)
35(a)
many ↔ many
many ↔ many
3L(6252265-6255794)
2R(9446050-9448273)
worm
(Caenorhabditis elegans)
Secernentea ldh-16
Protein LDH-1 (ldh-1) mRNA, complete cds
53(a)
1 → many
II(11725325-11726532) WBGene00002262


ENSEMBL Gene Tree for LDHAL6A (if available)
TreeFam Gene Tree for LDHAL6A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LDHAL6A gene
LDHAL6B2  UEVLD2  LDHB2  LDHA2  LDHC2  
5 SIMAP similar genes for LDHAL6A using alignment to 2 protein entries:     LDH6A_HUMAN (see all proteins):
LDHAL6B    LDHA    LDHB    LDHC    UEVLD

LDHAL6A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LDHAL6A (see all 700)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs27211221,2
C--18475449(-) GAGCCA/GAGATC 2 -- us2k14Minor allele frequency- G:0.00NA 8
rs1479685161,2
C--18475559(+) TTCACA/CGTTTT 2 -- us2k10--------
rs1172967291,2
F--18475731(+) TCTTGA/GGGGAG 2 -- us2k11Minor allele frequency- G:0.03EA 120
rs1417501711,2
C--18475791(+) TGTCAA/GTATGT 2 -- us2k10--------
rs1896539901,2
--18475821(+) CTAGAC/GGGACA 2 -- us2k10--------
rs1142696991,2
C,F--18475831(+) AGAACG/CAATAG 2 -- us2k11Minor allele frequency- C:0.03WA 118
rs1504444151,2
--18475869(+) ATTGAA/GGAGTA 2 -- us2k10--------
rs1138721531,2
C,F--18475873(+) AGGAGC/TATTGA 2 -- us2k11Minor allele frequency- T:0.50CSA 2
rs1488426051,2
C--18475911(+) CAACAA/CTAGGC 2 -- us2k10--------
rs1808818521,2
--18476018(+) AAAGAG/TGAAGG 2 -- us2k10--------

HapMap Linkage Disequilibrium report for LDHAL6A (18477371 - 18501147 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for LDHAL6A:    About this table    
Variant IDTypeSubtypePubMed ID
esv2744170CNV Deletion23290073
esv2744172CNV Deletion23290073
esv2744171CNV Deletion23290073
nsv509392CNV Insertion20534489
nsv897027CNV Loss21882294
nsv467719CNV Gain19166990
nsv510999CNV Complex20534489

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LDHAL6A
DNA2.0 Custom Variant and Variant Library Synthesis for LDHAL6A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for LDHAL6A:    About MalaCards
lactate dehydrogenase b deficiency    pneumonia    myocardial infarction

1 disease from the University of Copenhagen DISEASES database for LDHAL6A:
Myocardial infarction

LDHAL6A for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Export disorders for LDHAL6A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LDHAL6A gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with LDHAL6A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA). (PubMed id 18351441)1, 2, 9 Chen X.... Yu L. (Mol. Biol. Rep. 2009)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
  6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  7. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)
  8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  9. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. (PubMed id 17500595)1 Kaltenbach L.S....Hughes R.E. (PLoS Genet. 2007)
  10. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 160287 HGNC: 28335 AceView: LDHAL6A Ensembl:ENSG00000166800 euGenes: HUgn160287
ECgene: LDHAL6A Kegg: 160287 H-InvDB: LDHAL6A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for LDHAL6A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LDHAL6A gene:
Search GeneIP for patents involving LDHAL6A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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