Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LDHAL6A Gene

Aliases for LDHAL6A Gene

  • Lactate Dehydrogenase A Like 6A 2 3 5
  • EC 1.1.1.27 4 61
  • L-Lactate Dehydrogenase A-Like 6A 3
  • EC 1.1.1 61
  • LDH6A 3
  • LDHL2 4

External Ids for LDHAL6A Gene

Previous GeneCards Identifiers for LDHAL6A Gene

  • GC11P018163

Summaries for LDHAL6A Gene

GeneCards Summary for LDHAL6A Gene

LDHAL6A (Lactate Dehydrogenase A Like 6A) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Glucagon signaling pathway. GO annotations related to this gene include oxidoreductase activity and L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6B.

UniProtKB/Swiss-Prot for LDHAL6A Gene

  • Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LDHAL6A Gene

Genomics for LDHAL6A Gene

Regulatory Elements for LDHAL6A Gene

Enhancers for LDHAL6A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G018382 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -71.7 -71740 3.0 FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 FOS DEK LDHC LDHA LDHAL6A SPTY2D1 HPS5 TSG101 MIR3159 GC11P018375
GH11G018457 0.8 ENCODE 9.7 +1.8 1805 0.2 SOX13 MXI1 JUN MAX RFX5 FOSL1 GATA3 GATA2 RCOR1 NR2F6 LDHAL6A YWHABP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LDHAL6A on UCSC Golden Path with GeneCards custom track

Genomic Location for LDHAL6A Gene

Chromosome:
11
Start:
18,455,824 bp from pter
End:
18,479,600 bp from pter
Size:
23,777 bases
Orientation:
Plus strand

Genomic View for LDHAL6A Gene

Genes around LDHAL6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LDHAL6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LDHAL6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LDHAL6A Gene

Proteins for LDHAL6A Gene

  • Protein details for LDHAL6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMR3-LDH6A_HUMAN
    Recommended name:
    L-lactate dehydrogenase A-like 6A
    Protein Accession:
    Q6ZMR3
    Secondary Accessions:
    • D3DQY5

    Protein attributes for LDHAL6A Gene

    Size:
    332 amino acids
    Molecular mass:
    36507 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LDHAL6A Gene

Selected DME Specific Peptides for LDHAL6A Gene

Q6ZMR3:
  • GEHGDSSV
  • MDLQHGS
  • KLSGFPK
  • LNPDIGT
  • NLRRVHP
  • PKNRVIG
  • NLDSARFR
  • KSAETLW
  • NPVDILT
  • ILGEHGD
  • LVIITAGARQ
  • LDSARFR
  • ACAISIL
  • IGSGCNLD
  • GFPKNRV

Post-translational modifications for LDHAL6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for LDHAL6A Gene

Suggested Antigen Peptide Sequences for LDHAL6A Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMR3

UniProtKB/Swiss-Prot:

LDH6A_HUMAN :
  • Belongs to the LDH/MDH superfamily. LDH family.
Family:
  • Belongs to the LDH/MDH superfamily. LDH family.
genes like me logo Genes that share domains with LDHAL6A: view

No data available for Gene Families for LDHAL6A Gene

Function for LDHAL6A Gene

Molecular function for LDHAL6A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(S)-lactate + NAD(+) = pyruvate + NADH.
UniProtKB/Swiss-Prot Function:
Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.

Enzyme Numbers (IUBMB) for LDHAL6A Gene

Gene Ontology (GO) - Molecular Function for LDHAL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004459 L-lactate dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
genes like me logo Genes that share ontologies with LDHAL6A: view
genes like me logo Genes that share phenotypes with LDHAL6A: view

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LDHAL6A Gene

Localization for LDHAL6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LDHAL6A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LDHAL6A gene
Compartment Confidence
extracellular 5
cytosol 3

Gene Ontology (GO) - Cellular Components for LDHAL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with LDHAL6A: view

Pathways & Interactions for LDHAL6A Gene

genes like me logo Genes that share pathways with LDHAL6A: view

UniProtKB/Swiss-Prot Q6ZMR3-LDH6A_HUMAN

  • Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Gene Ontology (GO) - Biological Process for LDHAL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0019752 carboxylic acid metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LDHAL6A: view

No data available for SIGNOR curated interactions for LDHAL6A Gene

Drugs & Compounds for LDHAL6A Gene

(5) Drugs for LDHAL6A Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra 0
2-Ketobutyric acid Experimental Pharma 0
NADH Nutra Target 0
L-lactic acid Pharma Full agonist, Agonist 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for LDHAL6A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
  • (RS)-2-Hydroxybutyric acid
  • 2-Hydroxy-Butanoate
  • 2-Hydroxy-Butanoic acid
  • 2-Hydroxy-DL-Butyrate
600-15-7
3-Mercaptolactic acid
  • 3-Mercaptolactate
  • b-Mercaptolactate
  • b-Mercaptolactic acid
  • beta-Mercaptolactate
  • beta-Mercaptolactic acid
2614-83-7
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
2464-23-5
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with LDHAL6A: view

Transcripts for LDHAL6A Gene

mRNA/cDNA for LDHAL6A Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LDHAL6A Gene

Lactate dehydrogenase A-like 6A:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LDHAL6A Gene

No ASD Table

Relevant External Links for LDHAL6A Gene

GeneLoc Exon Structure for
LDHAL6A
ECgene alternative splicing isoforms for
LDHAL6A

Expression for LDHAL6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LDHAL6A Gene

mRNA differential expression in normal tissues according to GTEx for LDHAL6A Gene

This gene is overexpressed in Testis (x22.2).

Protein differential expression in normal tissues from HIPED for LDHAL6A Gene

This gene is overexpressed in Liver (50.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LDHAL6A Gene



NURSA nuclear receptor signaling pathways regulating expression of LDHAL6A Gene:

LDHAL6A

SOURCE GeneReport for Unigene cluster for LDHAL6A Gene:

Hs.668877

mRNA Expression by UniProt/SwissProt for LDHAL6A Gene:

Q6ZMR3-LDH6A_HUMAN
Tissue specificity: Testis-specific.

Evidence on tissue expression from TISSUES for LDHAL6A Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LDHAL6A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LDHAL6A Gene

Orthologs for LDHAL6A Gene

This gene was present in the common ancestor of animals.

Orthologs for LDHAL6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LDHAL6A 34 35
  • 99.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 65 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 59 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LDHA 35
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ldha 35
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ImpL3 35
  • 57 (a)
ManyToMany
CG13334 35
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ldh-1 35
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11301 35
  • 49 (a)
OneToMany
Species where no ortholog for LDHAL6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LDHAL6A Gene

ENSEMBL:
Gene Tree for LDHAL6A (if available)
TreeFam:
Gene Tree for LDHAL6A (if available)

Paralogs for LDHAL6A Gene

Paralogs for LDHAL6A Gene

(5) SIMAP similar genes for LDHAL6A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LDHAL6A: view

Variants for LDHAL6A Gene

Sequence variations from dbSNP and Humsavar for LDHAL6A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000006352 -- 18,462,834(+) CATCT(A/C)AAAAA intron-variant
rs1000080729 -- 18,462,044(+) GTAGG(C/T)GCCTG intron-variant
rs1000438738 -- 18,458,713(+) GAAAC(A/G)GTAAT intron-variant
rs1000447925 -- 18,468,357(+) TTTTT(C/G)AGATG intron-variant
rs1000555024 -- 18,470,981(+) AGCGC(A/C)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LDHAL6A Gene

Variant ID Type Subtype PubMed ID
esv2744170 CNV deletion 23290073
esv2744171 CNV deletion 23290073
esv2744172 CNV deletion 23290073
esv3625502 CNV loss 21293372
nsv467719 CNV gain 19166990
nsv509392 CNV insertion 20534489
nsv510999 OTHER complex 20534489
nsv553633 CNV gain 21841781
nsv553634 CNV gain 21841781

Variation tolerance for LDHAL6A Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LDHAL6A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LDHAL6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LDHAL6A Gene

Disorders for LDHAL6A Gene

Relevant External Links for LDHAL6A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LDHAL6A

No disorders were found for LDHAL6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LDHAL6A Gene

Publications for LDHAL6A Gene

  1. Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA). (PMID: 18351441) Chen X. … Yu L. (Mol. Biol. Rep. 2009) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for LDHAL6A Gene

Sources for LDHAL6A Gene

Content
Loading form....