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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LDHA Gene

protein-coding   GIFtS: 74
GCID: GC11P018415

Lactate Dehydrogenase A

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Lactate Dehydrogenase A1 2     GSD112 5
Cell Proliferation-Inducing Gene 19 Protein2 3     LDH12 5
Renal Carcinoma Antigen NY-REN-592 3     LDHM2
LDH-A2 3     L-Lactate Dehydrogenase A Chain2
LDH-M2 3     Lactate Dehydrogenase M2
LDH Muscle Subunit2 3     Proliferation-Inducing Gene 192
EC 1.1.1.273 8     EC 1.1.18

External Ids:    HGNC: 65351   Entrez Gene: 39392   Ensembl: ENSG000001343337   OMIM: 1500005   UniProtKB: P003383   
ORGUL members:         
NONCODE14:n408290      

Export aliases for LDHA gene to outside databases

Previous GC identifers: GC11P019537 GC11P019358 GC11P018455 GC11P018380 GC11P018372 GC11P018101


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LDHA Gene:
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final
step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate
dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript
variants encoding different isoforms have been found for this gene. The human genome contains several
non-transcribed pseudogenes of this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for LDHA Gene: 
LDHA (lactate dehydrogenase A) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with LDHA include lactate dehydrogenase a deficiency, and lactate dehydrogenase deficiency, and among its related super-pathways are Glycolysis and gluconeogenesis (short map) and Metabolic pathways. GO annotations related to this gene include nucleotide binding and L-lactate dehydrogenase activity. An important paralog of this gene is LDHAL6B.

Gene Wiki entry for LDHA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LDHA gene promoter:
         CREB   POU2F1   POU2F1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLDHA promoter sequence
   Search SABiosciences Chromatin IP Primers for LDHA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LDHA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

LDHA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LDHA gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018415:  view genomic region     (about GC identifiers)

Start:
18,415,935 bp from pter      End:
18,429,972 bp from pter
Size:
14,038 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LDHA_HUMAN, P00338 (See protein sequence)
Recommended Name: L-lactate dehydrogenase A chain  
Size: 332 amino acids; 36689 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for LDHA:
1I10 (3D)        4AJP (3D)        4JNK (3D)    
Secondary accessions: B4DKQ2 B7Z5E3 D3DQY3 F8W819 Q53G53 Q6IBM7 Q6ZNV1 Q9UDE8 Q9UDE9
Alternative splicing: 5 isoforms:  P00338-1   P00338-2   P00338-3   P00338-4   P00338-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LDHA: NX_P00338

Explore proteomics data for LDHA at MOPED 

Post-translational modifications:

  • UniProtKB: ISGylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P00338

  • 4/32 DME Specific Peptides for LDHA (P00338) (see all 32)
     NPVDILT  KSADTLW  IKLKGYT  VVESAYE 

    LDHA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LDHA Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001128711.1  NP_001158886.1  NP_001158887.1  NP_001158888.1  NP_005557.1  

    ENSEMBL proteins: 
     ENSP00000395337   ENSP00000440161   ENSP00000443545   ENSP00000406172   ENSP00000379524  
     ENSP00000444292   ENSP00000442979   ENSP00000440368   ENSP00000441058   ENSP00000443362  
     ENSP00000442637   ENSP00000227157   ENSP00000441241   ENSP00000446415   ENSP00000368722  
     ENSP00000445331   ENSP00000441699   ENSP00000445175  
    Reactome Protein details: P00338
    Human Recombinant Protein Products for LDHA: 
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    Cloud-Clone Corp. Proteins for LDHA 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0005929cilium IEA--

    LDHA for ontologies           About GeneDecksing



    LDHA Antibody Products: 
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    Cloud-Clone Corp. CLIAs for LDHA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR011304 L-lactate_DH
     IPR001236 Lactate/malate_DH_N
     IPR018177 L-lactate_DH_AS
     IPR022383 Lactate/malate_DH_C
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P00338

    ProtoNet protein and cluster: P00338

    2 Blocks protein domains:
    IPB001557 L-lactate dehydrogenase
    IPB011304 L-lactate dehydrogenase


    UniProtKB/Swiss-Prot: LDHA_HUMAN, P00338
    Similarity: Belongs to the LDH/MDH superfamily. LDH family


    LDHA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LDHA_HUMAN, P00338
    Catalytic activity: (S)-lactate + NAD(+) = pyruvate + NADH

         Genatlas biochemistry entry for LDHA:
    lactate dehydrogenase A,glycolysis,energy pathway,putative up-regulated c-Myc target gene,

         Enzyme Numbers (IUBMB): EC 1.1.1.271 2 EC 1.1.12

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004459L-lactate dehydrogenase activity NAS1953713
    GO:0005515protein binding IPI--
    GO:0016491oxidoreductase activity ----
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
         
    LDHA for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 13 alleles(MGI details for Ldha):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  normal  respiratory system  tumorigenesis 

    LDHA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LDHA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LDHA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LDHA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LDHA 

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate LDHA (see all 11):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-491-3p hsa-miR-501-3p hsa-miR-449a hsa-miR-33a hsa-miR-502-3p hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidLDHA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for LDHA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LDHA About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis (short map)
    Glycolysis and Gluconeogenesis0.60
    Glycolysis / Gluconeogenesis0.46
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Pyruvate metabolism
    Pyruvate metabolism0.60
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    4Development Ligand-independent activation of ESR1 and ESR2
    Transcription CREB pathway0.93
    5Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for LDHA
        Transcription CREB pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LDHA
        HIF1Alpha Pathway
    Metabolic States and Circadian Oscillators

    1 Cell Signaling Technology (CST) Pathway for LDHA
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for LDHA
        Transcription CREB pathway

    4 BioSystems Pathways for LDHA
        Glycolysis and Gluconeogenesis
    HIF-1-alpha transcription factor network
    Validated targets of C-MYC transcriptional activation
    pyruvate fermentation to lactate


    4        Reactome Pathways for LDHA
        Pyruvate metabolism
    Pyruvate metabolism and Citric Acid (TCA) cycle
    Metabolism
    The citric acid (TCA) cycle and respiratory electron transport


    5/6         Kegg Pathways  (Kegg details for LDHA) (see all 6):
        Glycolysis / Gluconeogenesis
    Cysteine and methionine metabolism
    Pyruvate metabolism
    Propanoate metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: LDHA_HUMAN, P00338
    Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1


    LDHA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LDHA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for LDHA (P003381, 2, 3 ENSP000003953374) via UniProtKB, MINT, STRING, and/or I2D (see all 84)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90AB1P082382, 3MINT-72650 I2D: score=3 
    YWHAZP631042, 3, ENSP000003095034MINT-3304540 I2D: score=1 STRING: ENSP00000309503
    KAT2AQ928303, ENSP000002259164I2D: score=3 STRING: ENSP00000225916
    XRN1Q8IZH23, ENSP000002649514I2D: score=3 STRING: ENSP00000264951
    H3F3AP842433I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006090pyruvate metabolic process TAS--
    GO:0006096glycolysis NAS1953713
    GO:0031668cellular response to extracellular stimulus IEA--
    GO:0044237cellular metabolic process TAS--

    LDHA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LDHA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LDHA

    2 HMDB Compounds for LDHA    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--

    5 DrugBank Compounds for LDHA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Etheno-Nad-- --target--17139284 17016423 10592235
    NADHbeta-DPNH (see all 18)606-68-8target--17006762 17308685 17555402
    Nicotinamide-- 98-92-0target--17139284 17016423 10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235
    Oxamic Acid-- 471-47-6target--17139284 17016423 10592235

    10/13 Novoseek inferred chemical compound relationships for LDHA gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactate 81.3 141 11085930 (3), 19088479 (2), 10671207 (2), 19033423 (2) (see all 70)
    pyruvate 70.2 26 15231792 (2), 11085930 (2), 12923786 (1), 17521432 (1) (see all 13)
    glucose 42.9 47 11085930 (7), 19797055 (2), 8529674 (2), 16098620 (1) (see all 15)
    glyceraldehyde 3-phosphate 41.5 6 15752986 (1), 16714762 (1), 7524903 (1), 10897012 (1)
    vegf 31.4 11 20368990 (2), 16884534 (1), 18086000 (1), 9746763 (1) (see all 8)
    nadh 25.4 1 16198644 (1)
    atp 23.3 1 20133848 (1)
    oxygen 18.8 8 16098620 (3), 15231792 (1), 17512623 (1)
    nadph 16.1 1 16198644 (1)
    agarose 0 1 1959923 (1)

    Search CenterWatch for drugs/clinical trials and news about LDHA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LDHA gene (5 alternative transcripts): 
    NM_001135239.1  NM_001165414.1  NM_001165415.1  NM_001165416.1  NM_005566.3  

    Unigene Cluster for LDHA:

    Lactate dehydrogenase A
    Hs.2795  [show with all ESTs]
    Unigene Representative Sequence: NM_001165414
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000422447(uc001mok.3 uc009yho.2 uc001mol.3 uc010rdc.1 uc021qep.1)
    ENST00000543445 ENST00000469976 ENST00000545467 ENST00000430553 ENST00000396222
    ENST00000535451 ENST00000494573 ENST00000539814 ENST00000543695 ENST00000536528
    ENST00000541097 ENST00000545215 ENST00000227157 ENST00000478970 ENST00000495052
    ENST00000379412 ENST00000542179
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LDHA

    Additional mRNA sequence: 

    AK026515.1 AK130035.1 AK130105.1 AK130587.1 AK223078.1 AK296089.1 AK296667.1 AK298834.1 
    AK307477.1 AY423727.1 BC067223.1 CR456775.1 CR541714.1 NR_028500.1 X02152.1 

    24/107 DOTS entries (see all 107):

    DT.95162838  DT.91790686  DT.95162817  DT.100738636  DT.100738608  DT.97811118  DT.120724436  DT.100738605 
    DT.100738612  DT.100738567  DT.100738607  DT.100738603  DT.92407662  DT.100738631  DT.100045658  DT.120724341 
    DT.100738569  DT.91882069  DT.120724437  DT.97833241  DT.97810430  DT.100688231  DT.100738592  DT.92330182 

    24/3372 AceView cDNA sequences (see all 3372):

    CB157310 AU103261 AL547809 CB138321 CR591694 BF149197 BM754281 AI422336 
    CR592881 BX396071 BQ215013 CB146563 T92573 BM820643 AA148030 BQ694322 
    AA506613 CD242954 CB135847 AA258849 CR623502 BM828563 AU103307 BP870448 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LDHA (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                            -                                         -     -               
    SP2:        -     -                             -                                                               
    SP3:              -           -                 -                                                               
    SP4:                          -                 -                                                               
    SP5:        -     -           -     -     -     -     -     -     -     -     -           -     -               


    ECgene alternative splicing isoforms for LDHA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LDHA expression in normal human tissues (normalized intensities)      LDHA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTGTGCAT
    LDHA Expression
    About this image


    LDHA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi

    See LDHA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LDHA

    SOURCE GeneReport for Unigene cluster: Hs.2795
        SABiosciences Expression via Pathway-Focused PCR Arrays including LDHA (see all 146): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LDHA gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ldha1 , 5 lactate dehydrogenase A1, 5 84.49(n)1
    90.86(a)1
      7 (30.60 cM)5
    168281  NM_001136069.21  NP_001129541.21 
     468414755 
    chicken
    (Gallus gallus)
    Aves LDHA1 lactate dehydrogenase A 79.6(n)
    85.15(a)
      396221  NM_205284.1  NP_990615.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    L-lactate dehydrogenase
    86(a)
    1 → many
    1(67792747-67811950)
    African clawed frog
    (Xenopus laevis)
    Amphibia ldha-prov2 lactate dehydrogenase A 78.26(n)    BC045015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570347782   -- 99.13(n)    57034778 
    fruit fly
    (Drosophila melanogaster)
    Insecta ImpL31 , 3 glycolysis L-lactate dehydrogenase3
    Ecdysone-inducible gene L31
    59(a)
    (best of 2)3
    59.04(n)1
    59.94(a)1
      65A113
    458801  NM_057233.41  NP_476581.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ldh-11 , 3 L-lactate dehydrogenase3
    Protein LDH-11
    61(a)3
    59.23(n)1
    59.02(a)1
      II(11725228-11726333)3
    1747981  NM_064102.41  NP_496503.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G172601 L-lactate dehydrogenase 54.56(n)
    54.34(a)
      827440  NM_117832.3  NP_193459.1 
    rice
    (Oryza sativa)
    Liliopsida AK106504.12   -- 74.23(n)    AK106504.1 


    ENSEMBL Gene Tree for LDHA (if available)
    TreeFam Gene Tree for LDHA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LDHA gene
    LDHAL6B2  UEVLD2  LDHB2  LDHAL6A2  LDHC2  
    5 SIMAP similar genes for LDHA using alignment to 11 protein entries:     LDHA_HUMAN (see all proteins):
    LDHC    LDHB    LDHAL6B    LDHAL6A    UEVLD

    LDHA for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for LDHA (see all 7)
    PGOHUM00000238635 PGOHUM00000245261 PGOHUM00000240118 PGOHUM00000259738 PGOHUM00000259778


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/488 SNPs in LDHA are shown (see all 488)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0041804
    ----see VAR_0041802 K E mis40--------
    VAR_0041814
    ----see VAR_0041812 R C mis40--------
    rs1452347871,2
    C--18107217(+) CACAC-/ACACAC 6 -- int10--------
    rs616821001,2
    C--18108202(+) TTATT-/G/    
       GATTC
    ATTCA
    6 -- int11CSA 2
    rs1400277211,2
    C--18108202(+) TTATT-/GATTC 
            
    ATTTA
    6 -- int10--------
    rs802026581,2
    --18109218(+) AAAAGG/TTTTTT 6 -- int10--------
    rs105624941,2
    C,F--18112596(+) GAAATAAAC/-  
            
    TATTT
    6 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1130019251,2
    C--18112599(+) ATAAAC/TTATTT 6 -- int10--------
    rs125780981,2
    H--18338208(+) ACCTAG/ATTTAT 5 -- us2k14Minor allele frequency- A:0.00NS EA 410
    rs1468481601,2
    --18338259(+) AGGTGA/GAAATT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for LDHA (18415935 - 18429972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LDHA:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744169CNV Deletion23290073
    nsv509392CNV Insertion20534489
    nsv39368CNV Loss16902084
    nsv510999CNV Complex20534489


    Human Gene Mutation Database (HGMD): LDHA
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 150000   
    OMIM disorders: 612933  
    UniProtKB/Swiss-Prot: LDHA_HUMAN, P00338
  • Glycogen storage disease 11 (GSD11) [MIM:612933]: A metabolic disorder that results in exertional
    myoglobinuria, pain, cramps and easy fatigue. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 20/68 diseases for LDHA (see all 68):    About MalaCards
    lactate dehydrogenase a deficiency    lactate dehydrogenase deficiency    hereditary leiomyomatosis and renal cell cancer    malignant germ cell tumor
    fanconi bickel syndrome    lactate dehydrogenase b deficiency    leiomyomatosis    fumarate hydratase deficiency
    diffuse astrocytoma    lymphosarcoma    chronic myeloproliferative disease    clostridium difficile
    breast adenocarcinoma    glycogen storage disease    noma    ependymoma
    panic disorder    soft tissue sarcoma    adult t-cell leukemia    germ cell tumors

    2 diseases from the University of Copenhagen DISEASES database for LDHA:
    Myocardial infarction     Cancer

    LDHA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for LDHA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyolysis 45.8 5 7630349 (1), 7549132 (1), 8327147 (1)
    cancer 30.7 15 19088479 (1), 19689405 (1), 18811052 (1), 9465046 (1) (see all 11)
    tumors 23.1 27 20133848 (4), 10897012 (2), 16766262 (2), 8116930 (1) (see all 12)
    breast cancer 1.67 8 19668225 (2), 20144215 (2), 12160330 (1)
    preeclampsia 0 2 11286567 (2)

    Genatlas disease: LDHA
    myoglobinuria,exertional and/or excessive fatigability

    Genetic Association Database (GAD): LDHA
    Human Genome Epidemiology (HuGE) Navigator: LDHA (5 documents)

    Export disorders for LDHA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LDHA gene, integrated from 9 sources (see all 235):
    (articles sorted by number of sources associating them with LDHA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of human lactate dehydrogenase-A gene. (PubMed id 3000353)1, 2, 3 Chung F.Z.... Li S.S.-L. (1985)
    2. Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder. (PubMed id 12555229)1, 4, 9 Philibert R.A....Coryell W.H. (2003)
    3. Genotypic analysis of families with lactate dehydrogenase A (M) deficiency by selective DNA amplification. (PubMed id 1959923)1, 2, 9 Maekawa M.... Kanno T. (1991)
    4. Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit. (PubMed id 1445373)1, 2, 9 Sudo K.... Toriumi J. (1992)
    5. Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining. (PubMed id 1953713)1, 2, 9 Maekawa M.... Kanno T. (1991)
    6. Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency. (PubMed id 2334430)1, 2, 9 Maekawa M....Li S.S. (1990)
    7. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    8. Genome-wide association study identifies two novel re gions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A. (PubMed id 21124955)1, 4 Marzi C....Gieger C. (2010)
    9. Detecting rare variants for complex traits using fami ly and unrelated data. (PubMed id 19847924)1, 4 Zhu X....Elston R.C. (2010)
    10. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3939 HGNC: 6535 AceView: LDHA Ensembl:ENSG00000134333 euGenes: HUgn3939
    ECgene: LDHA Kegg: 3939 H-InvDB: LDHA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LDHA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LDHA Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LDHA
    Wikipedia http://en.wikipedia.org/wiki/Lactate_dehydrogenase
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt109.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LDHA gene:
    Search GeneIP for patents involving LDHA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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