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LCTL Gene

protein-coding   GIFtS: 45
GCID: GC15M066840

Lactase-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
lactase-like1 2     KLPH2 3
KL Lactase Phlorizin Hydrolase1 2     KLG2
Klotho Gamma1 2     Lactase-Like Protein2
Klotho/Lactase-Phlorizin Hydrolase-Related Protein2 3     

External Ids:    HGNC: 155831   Entrez Gene: 1970212   Ensembl: ENSG000001885017   UniProtKB: Q6UWM73   

Export aliases for LCTL gene to outside databases

Previous GC identifers: GC15M064628 GC15M043675


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LCTL Gene:
This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and
are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved
glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been
characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane
domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for
catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jun 2013)

GeneCards Summary for LCTL Gene:
LCTL (lactase-like) is a protein-coding gene. Diseases associated with LCTL include osteoarthritis, and malaria. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is KL.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LCTL gene promoter:
         USF1   Elk-1   AP-1   Bach2   XBP-1   C/EBPalpha   PPAR-alpha   AREB6   c-Myb   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLCTL promoter sequence
   Search Chromatin IP Primers for LCTL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LCTL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q21.3

LCTL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LCTL gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M066840:  view genomic region     (about GC identifiers)

Start:
66,839,517 bp from pter      End:
66,858,317 bp from pter
Size:
18,801 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LCTL_HUMAN, Q6UWM7 (See protein sequence)
Recommended Name: Lactase-like protein precursor  
Size: 567 amino acids; 65088 Da
Caution: Although it belongs to the glycosyl hydrolase 1 family, Asp-201 is present instead of the conserved Glu
which is an active site residue. It is therefore expected that this protein lacks glycosidase activity

Explore the universe of human proteins at neXtProt for LCTL: NX_Q6UWM7

Explore proteomics data for LCTL at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn80, Asn171, Asn245
  • Modification sites at PhosphoSitePlus

  • See LCTL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265491.1  NP_997221.2  

    ENSEMBL proteins: 
     ENSP00000343490   ENSP00000445419   ENSP00000455793  

    LCTL Human Recombinant Protein Products:

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    Novus Biologicals LCTL Protein
    Novus Biologicals LCTL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LCTL

    LCTL Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cloud-Clone Corp. Antibodies for LCTL
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    LSBio Antibodies in human, mouse, rat for LCTL

    LCTL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LCTL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LCTL
    Cloud-Clone Corp. CLIAs for LCTL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017853 Glycoside_hydrolase_SF
     IPR001360 Glyco_hydro_1
     IPR018120 Glyco_hydro_1_AS
     IPR013781 Glyco_hydro_catalytic_dom

    Graphical View of Domain Structure for InterPro Entry Q6UWM7

    ProtoNet protein and cluster: Q6UWM7

    1 Blocks protein domain: IPB001360 Glycoside hydrolase

    UniProtKB/Swiss-Prot: LCTL_HUMAN, Q6UWM7
    Similarity: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily


    LCTL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds IEA--
         
    LCTL for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Lctl (no phenotypes)

    LCTL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lctltm1Lex for LCTL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LCTL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LCTL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LCTL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LCTL

    miRNA
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    Block miRNA regulation of human, mouse, rat LCTL using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate LCTL:
    hsa-miR-576-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidLCTL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LCTL
    Predesigned siRNA for gene silencing in human, mouse, rat LCTL

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LCTL

    Clone
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    OriGene clones in human, mouse for LCTL (see all 7)
    OriGene ORF clones in mouse, rat for LCTL
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    GenScript: all cDNA clones in your preferred vector: LCTL (NM_207338)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LCTL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCTL

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCTL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LCTL_HUMAN, Q6UWM7: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    peroxisome2
    extracellular1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    LCTL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LCTL
    Interactions:

        Search GeneGlobe Interaction Network for LCTL

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for LCTL (ENSP000003434904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR1ENSP000003802804STRING: ENSP00000380280
    FGFR4ENSP000002924084STRING: ENSP00000292408
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--

    LCTL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LCTL

    5 DrugBank Compounds for LCTL    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2s)-Hydroxy(4-Hydroxyphenyl)Ethanenitrile-- --target--17139284 17016423 10592235
    Beta-D-Glucose-- 50-99-7target--17139284 17016423 10592235
    Nojirimycine Tetrazole-- --target--17139284 17016423 10592235
    2,4-Dihydroxy-7-(Methyloxy)-2h-1,4-Benzoxazin-3(4h)-One-- --target--10592235
    PARA-NITROPHENYL 1-THIO-BETA-D-GLUCOPYRANOSIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LCTL gene (2 alternative transcripts): 
    NM_001278562.1  NM_207338.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341509(uc002aqc.3 uc010bhw.3) ENST00000537670(uc002aqd.4)
    ENST00000565875 ENST00000563438 ENST00000562179
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LCTL using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate LCTL:
    hsa-miR-576-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidLCTL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LCTL
    Predesigned siRNA for gene silencing in human, mouse, rat LCTL
    Clone
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    OriGene clones in human, mouse for LCTL (see all 7)
    OriGene ORF clones in mouse, rat for LCTL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LCTL (NM_207338)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LCTL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCTL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LCTL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LCTL
      QuantiTect SYBR Green Assays in human, mouse, rat LCTL
      QuantiFast Probe-based Assays in human, mouse, rat LCTL

    16 AceView cDNA sequences:

    BX448919 BM682357 BM706025 CD673793 AA486300 AK090598 BM683021 BM668946 
    AX746525 AY358729 BG192949 BM717826 NM_207338 BX097831 BG220352 AW393561 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LCTL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -           -                                                                     
    SP2:                          -                       -                                             
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for LCTL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LCTL expression in normal human tissues (normalized intensities)      LCTL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LCTL Expression
    About this image


    LCTL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
    LCTL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LCTL Protein Expression
        Custom PCR Arrays for LCTL
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LCTL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCTL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LCTL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lctl1 , 5 lactase-like1, 5 83.24(n)1
    83.89(a)1
      9 (34.50 cM)5
    2354351  NM_145835.21  NP_665834.11 
     641171475 
    lizard
    (Anolis carolinensis)
    Reptilia LCTL6
    lactase-like
    36(a)
    1 ↔ 1
    GL343361.1(22271-23084)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lctl1 lactase-like 70.19(n)
    71.8(a)
      100490497  XM_004912672.1  XP_004912729.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lctlb1 lactase-like b 68.74(n)
    70.88(a)
      564250  NM_001100014.2  NP_001093484.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97016
    --
    39(a)
    1 → many
    3L(16726646-16732464)
    worm
    (Caenorhabditis elegans)
    Secernentea klo-16
    klo-26
    Protein KLO-2 (klo-2) mRNA, complete cds
    33(a)
    32(a)
    many ↔ many
    many ↔ many
    IV(7745989-7748225) WBGene00016848
    III(2446223-2448643) WBGene00017103
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BGLU401 BGLU40 50.84(n)
    42.65(a)
      839196  NM_102418.3  NP_173978.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02128001 Os03g0212800 53.2(n)
    46.21(a)
      4332041  NM_001055893.1  NP_001049358.1 


    ENSEMBL Gene Tree for LCTL (if available)
    TreeFam Gene Tree for LCTL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LCTL gene
    KL2  KLB2  LCT2  GBA32  
    3 SIMAP similar genes for LCTL using alignment to 3 protein entries:     LCTL_HUMAN (see all proteins):
    LCT    GBA3    KLB

    LCTL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LCTL (see all 528)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124510671,2
    F--66842534(+) AGTAAA/GTATTT 1 -- int12Minor allele frequency- G:0.02CSA WA 120
    rs744736011,2
    F--66842542(+) TTTTTT/AAAAAT 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1914044501,2
    --66842636(+) GAGTCA/GAAGAA 1 -- int10--------
    rs1505095231,2
    --66842666(+) GTGTAC/TACTCT 1 -- int10--------
    rs13480351,2
    C,F,A,H--66842668(+) GTACAC/ATCTAG 1 -- int18Minor allele frequency- A:0.13NS NA WA 546
    rs789207791,2
    C,F--66842711(+) CTTATG/AGTTTT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1850688331,2
    --66842745(+) TCCTAC/TGGGGC 1 -- int10--------
    rs800121661,2
    F--66842806(+) TTTTTA/TTTAAG 1 -- int11Minor allele frequency- T:0.09WA 118
    rs1395296471,2
    --66842951(+) GTCAGC/TTGGGA 1 -- int10--------
    rs734741741,2
    C,F--66843009(+) ATGATA/GTCTTG 1 -- int12Minor allele frequency- G:0.12WA 120

    HapMap Linkage Disequilibrium report for LCTL (66839517 - 66858317 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LCTL: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LCTL
    DNA2.0 Custom Variant and Variant Library Synthesis for LCTL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for LCTL:    About MalaCards
    osteoarthritis    malaria

    1 disease from the University of Copenhagen DISEASES database for LCTL:
    Osteoarthritis

    LCTL for disorders           About GeneDecksing


    Export disorders for LCTL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LCTL gene integrated from 10 sources:
    (articles sorted by number of sources associating them with LCTL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. (PubMed id 12084582)1, 3 Ito S....Nabeshima Y. (Biochim. Biophys. Acta 2002)
    4. Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells. (PubMed id 22020932)1 Kim J....Wright W.E. (J. Biol. Chem. 2011)
    5. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    6. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    9. Sequence, structural, functional, and phylogenetic analyses of three glycosidase families. (PubMed id 9779294)1 Mian I.S. (amp 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 197021 HGNC: 15583 AceView: KLPH Ensembl:ENSG00000188501 euGenes: HUgn197021
    ECgene: LCTL H-InvDB: LCTL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LCTL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LCTL gene:
    Search GeneIP for patents involving LCTL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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