LCTL Gene
protein-coding GIFtS: 45
GCID: GC15M066840
|
|
lactase-like
| |
Aliases
for LCTL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Lactase-Like1 | | FLJ332791 | | KLPH1 2 3 | | KL Lactase Phlorizin Hydrolase2 | | KLG1 2 | | Klotho Gamma2 | | Klotho/Lactase-Phlorizin Hydrolase-Related Protein2 3 | | Lactase-Like Protein2 |
Export aliases for LCTL gene to outside databasesPrevious GC identifers: GC15M064628 GC15M043675 |
Summaries
for LCTL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LCTL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LCTL gene promoter:
USF1 Elk-1 AP-1 Bach2 XBP-1 C/EBPalpha PPAR-alpha AREB6 c-Myb MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for LCTL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCTL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q21.3LCTL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M066840: view genomic region
(about GC identifiers)
Start:
|
66,839,517 bp from pter |
End:
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66,858,317 bp from pter |
Size:
|
18,801 bases |
Orientation:
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minus strand |
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Proteins
for LCTL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LCTL_HUMAN, Q6UWM7 (See
protein sequence)Recommended Name: Lactase-like protein precursor Size: 567 amino acids; 65088 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
Caution: Although it belongs to the glycosyl hydrolase 1 family, Asp-201 is present instead of the conserved Glu whichis an active site residue. It is therefore expected that this protein lacks glycosidase activityExplore the universe of human proteins at neXtProt for LCTL: NX_Q6UWM7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UWM7
LCTL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997221.2
ENSEMBL proteins: ENSP00000343490 ENSP00000445419 ENSP00000455793
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
-- | -- | | GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
LCTL for ontologies About GeneDecksing
LCTL Antibody Products:
Assay Products for LCTL: |
Protein
Domains /
Families
for LCTL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LCTL for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UWM7ProtoNet protein and cluster: Q6UWM7 1 Blocks protein family: IPB001360 Glycoside hydrolase
UniProtKB/Swiss-Prot: LCTL_HUMAN, Q6UWM7Similarity: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily |
Function
for LCTL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCTL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCTL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LCTL (NM_207338) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LCTL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCTL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCTL |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
IEA | -- | | GO:0043169 | cation binding |
IEA | -- |
LCTL for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Lctltm1Lex for LCTL
1 MGI phenotypic allele  for Lctl (no phenotypes)
LCTL for phenotypes About GeneDecksing
|
Pathways & Interactions
for LCTL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LCTL
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
IEA | -- |
LCTL for ontologies About GeneDecksing
|
Drugs & Compounds
for LCTL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LCTL
5 DrugBank Compounds for LCTL About this table
Search CenterWatch for drugs/clinical trials and news about LCTL
|
Transcripts
for LCTL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LCTL gene: NM_207338.2 Unigene Cluster for LCTL: Lactase-like Hs.680983 [show with all ESTs]Unigene Representative Sequence: AK0905985 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000341509(uc002aqc.3 uc010bhw.3) ENST00000537670(uc002aqd.4)
ENST00000565875 ENST00000563438 ENST00000562179
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCTL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCTL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LCTL (NM_207338) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LCTL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCTL |
Additional cDNA sequence: AK090598.1 AK311441.1 AY358729.1 4 DOTS entries: DT.101979238 DT.100016711 DT.97831986 DT.97772928 16 AceView cDNA sequences: BM682357 AK090598 BM668946 BX448919 CD673793 AA486300 BM706025 AX746525 BM683021 AY358729 BM717826 BG192949 NM_207338 BX097831 BG220352 AW393561
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for LCTL About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
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| SP1: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LCTL
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Expression
for LCTL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LCTL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LCTL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LCTL
SOURCE GeneReport for Unigene cluster: Hs.680983
SABiosciences Custom PCR Arrays for LCTL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LCTL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LCTL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LCTL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCTL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCTL |
Orthologs
for LCTL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for LCTL gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for LCTL (if available)
TreeFam Gene Tree for LCTL (if available) |
Paralogs
for LCTL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LCTL gene
- KL2 KLB2 LCT2
3 SIMAP similar genes for LCTL using alignment to 3 protein entries: LCTL_HUMAN (see all proteins):LCT GBA3 KLB
LCTL for paralogs About GeneDecksing
|
Genomic Variants
for LCTL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LCTL (66839517 - 66858317 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LCTL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LCTL |
|
Disorders
/ Diseases
for LCTL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LCTL for disorders About GeneDecksing
2  diseases for LCTL: About MalaCardsosteoarthritis pneumonia
1 disease from the University of Copenhagen DISEASES database for LCTL:Osteoarthritis Export disorders for LCTL gene to outside databases
|
Publications
for LCTL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LCTL gene integrated from 9 sources:
(articles sorted by number of sources associating them with LCTL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. (PubMed id 12084582)1, 3 Ito S....Nabeshima Y. (2002)
- How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
- Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)
|
External Searches for LCTL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LCTL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LCTL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LCTL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LCTL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LCTL gene:
Search GeneIP for patents involving LCTL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LCTL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LCTL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LCTL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LCTL | | | OriGene Protein Over-expression Lysate for LCTL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LCTL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCTL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCTL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LCTL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LCTL | | OriGene Custom Protein Services for LCTL | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LCTL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LCTL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCTL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LCTL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCTL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LCTL |
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 |  |  |  | |
| | | | Search Tocris compounds for LCTL |
| |  |  |  |  | | | | |
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 |
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 | | | LCTL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCTL |
|  |  |  | | | | ThermoFisher Antibodies for LCTL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCTL |
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