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Aliases for LCTL Gene

Aliases for LCTL Gene

  • Lactase Like 2 3 5
  • Klotho/Lactase-Phlorizin Hydrolase-Related Protein 3 4
  • KL Lactase Phlorizin Hydrolase 2 3
  • Klotho Gamma 2 3
  • KLPH 3 4
  • Lactase-Like Protein 3
  • KLG 3

External Ids for LCTL Gene

Previous GeneCards Identifiers for LCTL Gene

  • GC15M064628
  • GC15M066840
  • GC15M043675

Summaries for LCTL Gene

Entrez Gene Summary for LCTL Gene

  • This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for LCTL Gene

LCTL (Lactase Like) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is LCT.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCTL Gene

Genomics for LCTL Gene

Regulatory Elements for LCTL Gene

Enhancers for LCTL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F066654 1.2 Ensembl ENCODE 6.2 -89.2 -89233 2.4 PKNOX1 ARID4B SIN3A ZNF2 RAD21 GLIS2 SCRT2 FOS THAP11 DEK LCTL SNAPC5 GC15P067956 LINC01169
GH15F066565 1.1 Ensembl ENCODE 6.4 -0.4 -422 2.4 YBX3 ARNT ARID4B NFXL1 DMAP1 RAD21 ZNF121 ZNF366 ZNF143 CREM TIPIN LCTL ENSG00000261351 LINC01169
GH15F066577 1.2 FANTOM5 Ensembl ENCODE 0.4 -12.4 -12384 0.9 ZNF664 HDAC2 RBAK JUN ZMYM3 ZNF24 MYC TCF7L2 RPL4 ZWILCH SNORD16 SNORD18A SNAPC5 MAP2K1 TIPIN DIS3L LINC01169 LCTL
GH15F066573 0.7 ENCODE 0.4 -8.2 -8223 2.0 ZNF263 PKNOX1 RFX1 DDX20 BHLHE40 ZIC2 GLIS1 IKZF1 EED ZNF512 RPL4 ZWILCH SNORD16 SNORD18A SNAPC5 TIPIN LCTL LINC01169
GH15F066580 0.7 Ensembl 0.3 -15.0 -15022 1.2 ESRRA JUN FEZF1 ZNF843 OSR2 CREB3 ZNF366 PBX2 IRF1 ZNF600 SNAPC5 LINC01169 TIPIN LCTL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LCTL on UCSC Golden Path with GeneCards custom track

Genomic Location for LCTL Gene

Chromosome:
15
Start:
66,547,179 bp from pter
End:
66,565,979 bp from pter
Size:
18,801 bases
Orientation:
Minus strand

Genomic View for LCTL Gene

Genes around LCTL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCTL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCTL Gene

Proteins for LCTL Gene

  • Protein details for LCTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWM7-LCTL_HUMAN
    Recommended name:
    Lactase-like protein
    Protein Accession:
    Q6UWM7
    Secondary Accessions:
    • B3KQY0

    Protein attributes for LCTL Gene

    Size:
    567 amino acids
    Molecular mass:
    65088 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LCTL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCTL Gene

Post-translational modifications for LCTL Gene

  • Glycosylation at Asn 80, Asn 171, and Asn 245
  • Modification sites at PhosphoSitePlus

Other Protein References for LCTL Gene

No data available for DME Specific Peptides for LCTL Gene

Domains & Families for LCTL Gene

Graphical View of Domain Structure for InterPro Entry

Q6UWM7

UniProtKB/Swiss-Prot:

LCTL_HUMAN :
  • Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
Family:
  • Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
genes like me logo Genes that share domains with LCTL: view

No data available for Gene Families for LCTL Gene

Function for LCTL Gene

Gene Ontology (GO) - Molecular Function for LCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008422 beta-glucosidase activity IBA --
genes like me logo Genes that share ontologies with LCTL: view
genes like me logo Genes that share phenotypes with LCTL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LCTL

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LCTL Gene

Localization for LCTL Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCTL Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCTL gene
Compartment Confidence
endoplasmic reticulum 4
peroxisome 2
plasma membrane 1
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IBA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005903 brush border IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LCTL: view

Pathways & Interactions for LCTL Gene

No Data Available

Interacting Proteins for LCTL Gene

Gene Ontology (GO) - Biological Process for LCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:1901657 glycosyl compound metabolic process IBA --
genes like me logo Genes that share ontologies with LCTL: view

No data available for Pathways by source and SIGNOR curated interactions for LCTL Gene

Drugs & Compounds for LCTL Gene

(5) Drugs for LCTL Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2s)-Hydroxy(4-Hydroxyphenyl)Ethanenitrile Experimental Pharma Target 0
2,4-Dihydroxy-7-(Methyloxy)-2h-1,4-Benzoxazin-3(4h)-One Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0
Nojirimycine Tetrazole Experimental Pharma Target 0
PARA-NITROPHENYL 1-THIO-BETA-D-GLUCOPYRANOSIDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with LCTL: view

Transcripts for LCTL Gene

mRNA/cDNA for LCTL Gene

Unigene Clusters for LCTL Gene

Lactase-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCTL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for LCTL Gene

GeneLoc Exon Structure for
LCTL
ECgene alternative splicing isoforms for
LCTL

Expression for LCTL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LCTL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCTL Gene

This gene is overexpressed in Nerve - Tibial (x23.4) and Brain - Spinal cord (cervical c-1) (x7.6).

NURSA nuclear receptor signaling pathways regulating expression of LCTL Gene:

LCTL

SOURCE GeneReport for Unigene cluster for LCTL Gene:

Hs.680983
genes like me logo Genes that share expression patterns with LCTL: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for LCTL Gene

Orthologs for LCTL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LCTL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCTL 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia LCTL 34 35
  • 89.01 (n)
cow
(Bos Taurus)
Mammalia LCTL 34 35
  • 88.75 (n)
mouse
(Mus musculus)
Mammalia Lctl 34 16 35
  • 83.24 (n)
oppossum
(Monodelphis domestica)
Mammalia LCTL 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCTL 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LCTL 35
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lctl 34
  • 70.19 (n)
zebrafish
(Danio rerio)
Actinopterygii lctlb 34 35
  • 68.74 (n)
lctla 35
  • 64 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006425 34
  • 54.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9701 35
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klo-1 35
  • 33 (a)
ManyToMany
klo-2 35
  • 32 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BGLU40 34
  • 50.84 (n)
rice
(Oryza sativa)
Liliopsida Os03g0212800 34
  • 53.2 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00130 34
  • 49.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for LCTL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LCTL Gene

ENSEMBL:
Gene Tree for LCTL (if available)
TreeFam:
Gene Tree for LCTL (if available)

Paralogs for LCTL Gene

Paralogs for LCTL Gene

(3) SIMAP similar genes for LCTL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LCTL: view

Variants for LCTL Gene

Sequence variations from dbSNP and Humsavar for LCTL Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1030986 -- 66,558,024(+) CCAGG(C/T)TTTGG intron-variant, reference, missense
rs11071898 -- 66,548,695(+) ATTGG(A/G)AAAAC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs11071899 -- 66,552,828(+) GTAGA(C/T)GTGAG intron-variant
rs111304846 -- 66,556,555(+) CCACC(G/T)TGGCC intron-variant
rs111373206 -- 66,561,897(+) GCTCA(G/T)CACTC intron-variant

Variation tolerance for LCTL Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCTL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCTL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LCTL Gene

Disorders for LCTL Gene

Relevant External Links for LCTL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCTL

No disorders were found for LCTL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCTL Gene

Publications for LCTL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. (PMID: 12084582) Ito S. … Nabeshima Y. (Biochim. Biophys. Acta 2002) 2 3 64
  5. Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells. (PMID: 22020932) Kim J. … Wright W.E. (J. Biol. Chem. 2011) 3 64

Products for LCTL Gene

Sources for LCTL Gene

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