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Aliases for LCP2 Gene

Aliases for LCP2 Gene

  • Lymphocyte Cytosolic Protein 2 2 3 5
  • Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein Of 76kDa) 2 3
  • SH2 Domain-Containing Leukocyte Protein Of 76 KDa 3 4
  • SH2 Domain-Containing Leukocyte Protein Of 76kD 2 3
  • 76 KDa Tyrosine Phosphoprotein 2 3
  • SLP-76 Tyrosine Phosphoprotein 3 4
  • SLP76 3 4
  • Lymphocyte Cytosolic Protein 2 (SH2 Domain-Containing Leukocyte Protein Of 76kD) 2
  • SLP-76 3

External Ids for LCP2 Gene

Previous HGNC Symbols for LCP2 Gene

  • SLP76

Previous GeneCards Identifiers for LCP2 Gene

  • GC05M169910
  • GC05M170378
  • GC05M169610
  • GC05M169655
  • GC05M169607
  • GC05M169675
  • GC05M164773
  • GC05M169673

Summaries for LCP2 Gene

Entrez Gene Summary for LCP2 Gene

  • SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008]

GeneCards Summary for LCP2 Gene

LCP2 (Lymphocyte Cytosolic Protein 2) is a Protein Coding gene. Diseases associated with LCP2 include B Cell Linker Protein Deficiency. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Interleukin-3, 5 and GM-CSF signaling. An important paralog of this gene is BLNK.

UniProtKB/Swiss-Prot for LCP2 Gene

  • Involved in T-cell antigen receptor mediated signaling.

Gene Wiki entry for LCP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCP2 Gene

Genomics for LCP2 Gene

Regulatory Elements for LCP2 Gene

Enhancers for LCP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around LCP2 on UCSC Golden Path with GeneCards custom track

Promoters for LCP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for LCP2 Gene

Chromosome:
5
Start:
170,246,237 bp from pter
End:
170,298,227 bp from pter
Size:
51,991 bases
Orientation:
Minus strand

Genomic View for LCP2 Gene

Genes around LCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCP2 Gene

Proteins for LCP2 Gene

  • Protein details for LCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13094-LCP2_HUMAN
    Recommended name:
    Lymphocyte cytosolic protein 2
    Protein Accession:
    Q13094
    Secondary Accessions:
    • A8KA25
    • Q53XV4

    Protein attributes for LCP2 Gene

    Size:
    533 amino acids
    Molecular mass:
    60188 Da
    Quaternary structure:
    • Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB. Interacts with SHB (PubMed:12084069). Interacts with PRAM1 (PubMed:11301322). Interacts (via SH2 domain) with CD6 (via tyrosine phosphorylated C-terminus) (PubMed:16914752, PubMed:24584089).

    Three dimensional structures from OCA and Proteopedia for LCP2 Gene

neXtProt entry for LCP2 Gene

Post-translational modifications for LCP2 Gene

  • Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LCP2 (SLP76)
  • Abcam antibodies for SLP76

No data available for DME Specific Peptides for LCP2 Gene

Domains & Families for LCP2 Gene

Gene Families for LCP2 Gene

Protein Domains for LCP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13094

UniProtKB/Swiss-Prot:

LCP2_HUMAN :
  • The SH2 domain mediates interaction with phosphorylated CD6 (PubMed:16914752). The SH2 domain mediates interaction with SHB (PubMed:12084069).
Domain:
  • The SH2 domain mediates interaction with phosphorylated CD6 (PubMed:16914752). The SH2 domain mediates interaction with SHB (PubMed:12084069).
  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with LCP2: view

Function for LCP2 Gene

Molecular function for LCP2 Gene

GENATLAS Biochemistry:
leukocyte protein 76kDa (SLP-76),expressed in cells of hematopoietic origin,phosphorylated by TCR coupled tyrosine kinase
UniProtKB/Swiss-Prot Function:
Involved in T-cell antigen receptor mediated signaling.

Gene Ontology (GO) - Molecular Function for LCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8673706
genes like me logo Genes that share ontologies with LCP2: view
genes like me logo Genes that share phenotypes with LCP2: view

Animal Models for LCP2 Gene

MGI Knock Outs for LCP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LCP2 Gene

Localization for LCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCP2 Gene COMPARTMENTS Subcellular localization image for LCP2 gene
Compartment Confidence
cytosol 5
plasma membrane 5
cytoskeleton 2
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
GO:0036398 TCR signalosome IDA 20551903
GO:0044853 plasma membrane raft IDA 20551903
genes like me logo Genes that share ontologies with LCP2: view

Pathways & Interactions for LCP2 Gene

genes like me logo Genes that share pathways with LCP2: view

SIGNOR curated interactions for LCP2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 7706237
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 7706237
GO:0030168 platelet activation TAS --
GO:0035556 intracellular signal transduction IBA --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with LCP2: view

Drugs & Compounds for LCP2 Gene

(5) Drugs for LCP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for LCP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LCP2: view

Transcripts for LCP2 Gene

Unigene Clusters for LCP2 Gene

Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCP2 Gene

No ASD Table

Relevant External Links for LCP2 Gene

GeneLoc Exon Structure for
LCP2
ECgene alternative splicing isoforms for
LCP2

Expression for LCP2 Gene

mRNA expression in normal human tissues for LCP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCP2 Gene

This gene is overexpressed in Whole Blood (x21.7) and Spleen (x4.8).

Protein differential expression in normal tissues from HIPED for LCP2 Gene

This gene is overexpressed in NK cells (18.0), Peripheral blood mononuclear cells (12.3), CD8 Tcells (10.0), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LCP2 Gene



Protein tissue co-expression partners for LCP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LCP2 Gene:

LCP2

SOURCE GeneReport for Unigene cluster for LCP2 Gene:

Hs.304475

mRNA Expression by UniProt/SwissProt for LCP2 Gene:

Q13094-LCP2_HUMAN
Tissue specificity: Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.
genes like me logo Genes that share expression patterns with LCP2: view

Primer Products

Orthologs for LCP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LCP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LCP2 34
  • 84.96 (n)
  • 83.83 (a)
LCP2 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LCP2 34
  • 88.06 (n)
  • 90.81 (a)
LCP2 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lcp2 34
  • 84.57 (n)
  • 84.63 (a)
Lcp2 16
Lcp2 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LCP2 34
  • 99.44 (n)
  • 99.62 (a)
LCP2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lcp2 34
  • 85.01 (n)
  • 86.68 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LCP2 34
  • 65.38 (n)
  • 59.81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lcp2 34
  • 54.02 (n)
  • 48.43 (a)
zebrafish
(Danio rerio)
Actinopterygii lcp2b 34
  • 54.15 (n)
  • 45.39 (a)
lcp2b 35
  • 33 (a)
ManyToMany
Species where no ortholog for LCP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LCP2 Gene

ENSEMBL:
Gene Tree for LCP2 (if available)
TreeFam:
Gene Tree for LCP2 (if available)

Paralogs for LCP2 Gene

Paralogs for LCP2 Gene

(1) SIMAP similar genes for LCP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with LCP2: view

Variants for LCP2 Gene

Sequence variations from dbSNP and Humsavar for LCP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34192428 - 170,253,135(-) CCCAT(C/G)CCCCG reference, missense
rs170283 -- 170,272,796(-) tctct(A/G)ctaaa intron-variant
rs182618 -- 170,296,109(-) GATAA(A/G)GGAAA intron-variant
rs1628280 -- 170,291,002(+) AAAGA(A/G)AGAAA intron-variant
rs315717 -- 170,258,159(+) GGTCT(C/T)TGATG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for LCP2 Gene

Variant ID Type Subtype PubMed ID
esv2304012 CNV deletion 18987734
nsv462515 CNV loss 19166990
nsv471054 CNV loss 18288195
nsv5125 CNV insertion 18451855
nsv600260 CNV loss 21841781
nsv830547 CNV gain+loss 17160897
nsv950440 CNV duplication 24416366

Variation tolerance for LCP2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCP2 Gene

Disorders for LCP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LCP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
b cell linker protein deficiency
  • b-cell linker protein deficiency
- elite association - COSMIC cancer census association via MalaCards
Search LCP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LCP2

Genetic Association Database (GAD)
LCP2
Human Genome Epidemiology (HuGE) Navigator
LCP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCP2
genes like me logo Genes that share disorders with LCP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LCP2 Gene

Publications for LCP2 Gene

  1. CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. (PMID: 16914752) Hassan N.J. … Brown M.H. (Mol. Cell. Biol. 2006) 3 4 22 65
  2. Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. (PMID: 15388330) Shim E.K. … Lee J.R. (FEBS Lett. 2004) 3 4 22 65
  3. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. (PMID: 7706237) Jackman J.K. … Findell P.R. (J. Biol. Chem. 1995) 2 3 4 65
  4. Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. (PMID: 21725281) Sela M. … Yablonski D. (EMBO J. 2011) 3 4 65
  5. c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest. (PMID: 19635790) Shen M. … Yen A. (J. Biol. Chem. 2009) 3 22 65

Products for LCP2 Gene

Sources for LCP2 Gene

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