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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LCP2 Gene

protein-coding   GIFtS: 63
GCID: GC05M169673

Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte...

(Previous name: lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte...)
(Previous symbol: SLP76)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein
Of 76kDa)1 2
     SLP-76 Tyrosine Phosphoprotein2 3
SLP761 2 3 5     Lymphocyte Cytosolic Protein 2 (SH2 Domain-Containing Leukocyte Protein Of
76kD)1
76 KDa Tyrosine Phosphoprotein1 2     SLP-762
SH2 Domain-Containing Leukocyte Protein Of 76kD1 2     Lymphocyte Cytosolic Protein 22
SH2 Domain-Containing Leukocyte Protein Of 76 KDa2 3     

External Ids:    HGNC: 65291   Entrez Gene: 39372   Ensembl: ENSG000000434627   OMIM: 6016035   UniProtKB: Q130943   

Export aliases for LCP2 gene to outside databases

Previous GC identifers: GC05M169910 GC05M170378 GC05M169610 GC05M169655 GC05M169607 GC05M169675 GC05M164773


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LCP2 Gene:
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor
(TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33
and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino
acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic
region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation.
SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional
proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor
ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76
deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T
cell development and activation as well as mast cell and platelet function. (provided by RefSeq, Jul 2008)

GeneCards Summary for LCP2 Gene: 
LCP2 (lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)) is a protein-coding gene. Diseases associated with LCP2 include wiskott-aldrich syndrome, and lymphedema, and among its related super-pathways are Immune response BCR pathway and PKC-Theta Pathway. GO annotations related to this gene include protein binding. An important paralog of this gene is BLNK.

UniProtKB/Swiss-Prot: LCP2_HUMAN, Q13094
Function: Involved in T-cell antigen receptor mediated signaling

Gene Wiki entry for LCP2 (Lymphocyte cytosolic protein 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LCP2 gene promoter:
         HOXA9   HOXA9B   AML1a   Bach2   Nkx2-2   FOXD3   Meis-1b   Pax-4a   Meis-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLCP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LCP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

LCP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LCP2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M169673:  view genomic region     (about GC identifiers)

Start:
169,673,241 bp from pter      End:
169,725,231 bp from pter
Size:
51,991 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LCP2_HUMAN, Q13094 (See protein sequence)
Recommended Name: Lymphocyte cytosolic protein 2  
Size: 533 amino acids; 60188 Da
Subunit: Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and
FYB. Interacts with SHB. Interacts with PRAM1
Subcellular location: Cytoplasm (Probable)
4 PDB 3D structures from and Proteopedia for LCP2:
1H3H (3D)        1YWO (3D)        2EAP (3D)        2ROR (3D)    
Secondary accessions: Q53XV4

Explore the universe of human proteins at neXtProt for LCP2: NX_Q13094

Explore proteomics data for LCP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1
    preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13094

  • LCP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LCP2 Protein Expression
    REFSEQ proteins: NP_005556.1  
    ENSEMBL proteins: 
     ENSP00000046794   ENSP00000428871   ENSP00000430391  
    Reactome Protein details: Q13094
    Human Recombinant Protein Products for LCP2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LCP2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    LCP2 for ontologies           About GeneDecksing



    LCP2 Antibody Products: 
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    Assay Products for LCP2: 
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    Cloud-Clone Corp. ELISAs for LCP2 
    Cloud-Clone Corp. CLIAs for LCP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q13094

    ProtoNet protein and cluster: Q13094

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: LCP2_HUMAN, Q13094
    Domain: The SH2 domain mediates interaction with SHB
    Similarity: Contains 1 SAM (sterile alpha motif) domain
    Similarity: Contains 1 SH2 domain


    LCP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LCP2_HUMAN, Q13094
    Function: Involved in T-cell antigen receptor mediated signaling

         Genatlas biochemistry entry for LCP2:
    leukocyte protein 76kDa (SLP-76),expressed in cells of hematopoietic origin,phosphorylated by TCR coupled tyrosine
    kinase

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10229072
         
    LCP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LCP2:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Decreased telomerase activity 

         8 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Lcp2):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  respiratory system 

    LCP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LCP2: Lcp2tm1Geha Lcp2tm1.1Wz Lcp2tm1Gak

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LCP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LCP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LCP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LCP2 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate LCP2:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidLCP2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LCP2 About   (see all 29)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Fc-epsilon receptor I signaling in mast cells0.33
    Fc epsilon RI signaling pathway0.40
    Natural killer cell mediated cytotoxicity0.31
    2PKC-Theta Pathway
    TCR Signaling0.68
    ITK and TCR Signaling0.54
    PKC-Theta Pathway0.68
    Fc-EpsilonRI Pathway0.49
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    4Signaling by FGFR
    DAP12 signaling0.91
    DAP12 interactions0.91
    5ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    CD28 Signaling in T-Helper Cell0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for LCP2 (see all 6)
        Immune response CD28 signaling
    Immune response NFAT in immune response
    Immune response Fc epsilon RI pathway
    Immune response ICOS pathway in T-helper cell
    G-protein signaling Regulation of RAC1 activity

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LCP2 (see all 12)
        ICos-ICosL Pathway in T-Helper Cell
    Rap1 Pathway
    CD28 Signaling in T-Helper Cell
    Tec Kinases Signaling
    CTLA4 Signaling

    2 Cell Signaling Technology (CST) Pathways for LCP2
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    5/6 GeneGo (Thomson Reuters) Pathways for LCP2 (see all 6)
        G-protein signaling Regulation of RAC1 activity
    Immune response Fc epsilon RI pathway
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response CD28 signaling

    5 BioSystems Pathways for LCP2
        B Cell Receptor Signaling Pathway
    TCR signaling in naive CD4+ T cells
    Fc-epsilon receptor I signaling in mast cells
    TCR signaling in naive CD8+ T cells
    JNK signaling in the CD4+ TCR pathway


    5/13        Reactome Pathways for LCP2 (see all 13)
        Hemostasis
    FCERI mediated MAPK activation
    Adaptive Immune System
    GPVI-mediated activation cascade
    DAP12 interactions


    4         Kegg Pathways  (Kegg details for LCP2):
        Osteoclast differentiation
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway
    Fc epsilon RI signaling pathway


    LCP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LCP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/101 Interacting proteins for LCP2 (Q130941, 2, 3 ENSP000000467944) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163332, 3, ENSP000002889864MINT-7995411 MINT-7995531 MINT-7995426 MINT-7995458 MINT-8029667 MINT-7995504 MINT-8224277 MINT-7306527 MINT-7995396 MINT-7995442 MINT-8037396 MINT-7995380 MINT-7995488 MINT-7995474 I2D: score=7 STRING: ENSP00000288986
    VAV1P154982, 3, ENSP000003022694MINT-8037365 MINT-8029636 MINT-8029651 MINT-8029682 MINT-8224277 MINT-8037350 MINT-8037411 MINT-8037380 MINT-8029621 I2D: score=7 STRING: ENSP00000302269
    GRAP2O757912, 3, ENSP000003391864MINT-4302429 MINT-7306546 MINT-4302374 MINT-4302356 MINT-4302410 MINT-7041321 MINT-4302332 MINT-4302391 MINT-4302284 I2D: score=10 STRING: ENSP00000339186
    GRB2P629932, 3, ENSP000003390074MINT-4302482 MINT-4302502 MINT-7306677 MINT-7306559 MINT-7306657 I2D: score=6 STRING: ENSP00000339007
    PLCG1P191742, 3, ENSP000002440074MINT-7306637 MINT-8224277 MINT-7306572 I2D: score=4 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS7706237
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS7706237
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    LCP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LCP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LCP2

    10/11 Novoseek inferred chemical compound relationships for LCP2 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.1 100 10026222 (6), 8892604 (3), 16456002 (3), 9716598 (3) (see all 57)
    phosphotyrosine 38.1 3 12356870 (1), 15699116 (1), 16479002 (1)
    phosphoinositide 19 6 11090061 (4), 15388330 (1)
    calcium 17.2 10 16479002 (2), 12356870 (1), 10934198 (1), 15699116 (1) (see all 8)
    fibrinogen 12.3 6 11050236 (3), 11113155 (2), 11940607 (1)
    lipid 2.36 5 12670393 (1), 12356870 (1), 16919152 (1), 15699116 (1) (see all 5)
    threonine 0 1 8666952 (1)
    phosphatidylinositol 0 2 12670393 (1), 9195899 (1)
    proline 0 1 8666952 (1)
    serine 0 2 17353368 (1), 8666952 (1)

    Search CenterWatch for drugs/clinical trials and news about LCP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LCP2 gene: 
    NM_005565.3  

    Unigene Cluster for LCP2:

    Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
    Hs.304475  [show with all ESTs]
    Unigene Representative Sequence: NM_005565
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000046794(uc011des.1 uc003man.1 uc011det.1 uc010jjo.1)
    ENST00000520322 ENST00000521416 ENST00000523369 ENST00000520344 ENST00000519594
    ENST00000522760 ENST00000522823 ENST00000519149
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    Additional mRNA sequence: 

    AK122637.1 AK292890.1 AK296098.1 AK300000.1 AK310369.1 BC016618.1 BT007273.1 FN432830.1 
    U20158.1 

    10 DOTS entries:

    DT.414143  DT.208285  DT.75193588  DT.100755390  DT.414145  DT.91807669  DT.97838721  DT.99963570 
    DT.120798303  DT.40274855 

    24/94 AceView cDNA sequences (see all 94):

    AW204380 BT007273 BG057319 AA937429 NM_005565 BC016618 BF476782 AW768566 
    D62832 AA770606 AI804386 BF196815 AI033178 BI835477 BI030866 CA414205 
    CD520413 AA344958 BU632106 BI831193 AI768992 N98660 CD642168 CD641799 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LCP2 expression in normal human tissues (normalized intensities)      LCP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LCP2 Expression
    About this image


    LCP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             c-kit+ gr1+ mac1- myeloblasts   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier

    See LCP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LCP2

    SOURCE GeneReport for Unigene cluster: Hs.304475

    UniProtKB/Swiss-Prot: LCP2_HUMAN, Q13094
    Tissue specificity: Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in
    T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or
    neuroblastoma cell lines

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LCP2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lcp21 , 5 lymphocyte cytosolic protein 21, 5 84.57(n)1
    84.63(a)1
      11 (19.43 cM)5
    168221  NM_010696.31  NP_034826.21 
     340469205 
    chicken
    (Gallus gallus)
    Aves LCP21 lymphocyte cytosolic protein 2 (SH2 domain containing more 65.38(n)
    59.62(a)
      395438  NM_204701.1  NP_990032.1 
    lizard
    (Anolis carolinensis)
    Reptilia LCP26
    Uncharacterized protein
    50(a)
    1 ↔ 1
    2(120665280-120707798)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1018091 zgc:101809 50.73(n)
    44.07(a)
      336073  NM_214717.1  NP_999882.1 


    ENSEMBL Gene Tree for LCP2 (if available)
    TreeFam Gene Tree for LCP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LCP2 gene
    BLNK2  CLNK2  SH2D62  
    1 SIMAP similar gene for LCP2 using alignment to 6 protein entries:     LCP2_HUMAN (see all proteins):
    CLNK

    LCP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1219 SNPs in LCP2 are shown (see all 1219)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829621211,2
    --169674629(+) AAGTGA/CTATTT 1 -- ds50010--------
    rs1859902991,2
    C--169674887(+) TGATGA/GTTGGT 1 -- ds50010--------
    rs1903152791,2
    --169674934(+) CCAGAC/TGTGTT 1 -- ds50010--------
    rs1158079811,2
    F--169674941(+) TGTTCA/GTTAAA 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs754579531,2
    C--169674957(+) ACCCAC/GGATAC 1 -- ds50010--------
    rs795211881,2
    C--169674958(+) CCCACA/G/TATACA 1 -- ds50010--------
    rs100452901,2
    C,F,H--169675146(+) TTCATA/TAAAAA 1 -- ut317Minor allele frequency- T:0.08NS EA WA 656
    rs100397961,2
    C,F,A,H--169675165(+) AAAATG/CCCCCC 1 -- ut3110Minor allele frequency- C:0.42NS EA NA WA 778
    rs1176233821,2
    C,F--169675318(+) AAACAA/GATCAG 1 -- ut311Minor allele frequency- G:0.01EA 120
    rs1828161761,2
    --169675449(+) AATTAC/TTACAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LCP2 (169673241 - 169725231 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LCP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2304012CNV Deletion18987734
    nsv5125CNV Insertion18451855
    nsv471054CNV Loss18288195
    nsv462515CNV Loss19166990
    nsv830547CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601603    OMIM disorders: --

    8 diseases for LCP2:    About MalaCards
    wiskott-aldrich syndrome    lymphedema    agammaglobulinemia    acute promyelocytic leukemia
    systemic lupus erythematosus    lupus erythematosus    neuroblastoma    leukemia


    LCP2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for LCP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 36.6 1 11739662 (1)
    leukemia t-cell 20.1 3 17178387 (2), 12496421 (1)
    lymphoma t-cell 11.8 1 14984504 (1)
    bleeding 0 1 11050236 (1)

    Genetic Association Database (GAD): LCP2
    Human Genome Epidemiology (HuGE) Navigator: LCP2 (4 documents)

    Export disorders for LCP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LCP2 gene, integrated from 9 sources (see all 201):
    (articles sorted by number of sources associating them with LCP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. (PubMed id 7706237)1, 2, 3 Jackman J.K.... Findell P.R. (1995)
    2. Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. (PubMed id 15388330)1, 2, 9 Shim E.K....Lee J.R. (2004)
    3. Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. (PubMed id 21725281)1, 2 Sela M....Yablonski D. (2011)
    4. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (2008)
    5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells. (PubMed id 12084069)1, 2 Lindholm C.K.... Welsh M. (2002)
    8. PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. (PubMed id 11301322)1, 2 Moog-Lutz C....Koretzky G. (2001)
    9. Retinoic acid induces expression of SLP-76: expression with c-FMS enhances ERK activation and retinoic acid-induced differentiation/G0 arrest of HL-60 cells. (PubMed id 16439309)1, 9 Yen A....Lamkin T.J. (2006)
    10. Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. (PubMed id 11390650)1, 9 Yablonski D....Weiss A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3937 HGNC: 6529 AceView: LCP2 Ensembl:ENSG00000043462 euGenes: HUgn3937
    ECgene: LCP2 Kegg: 3937 H-InvDB: LCP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LCP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LCP2 gene:
    Search GeneIP for patents involving LCP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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