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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LCP2 Gene

protein-coding GIFtS: 62
GCID: GC05M169673

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte...

(Previous name: lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte...)
(Previous symbol: SLP76)

Explore 9 diseases affiliated with
LCP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein Of 76kDa)¹ ²		Lymphocyte Cytosolic Protein 2 (SH2 Domain-Containing Leukocyte Protein Of 76kD)¹
SLP76¹ ² ³ ⁵		76 KDa Tyrosine Phosphoprotein²
SLP-76¹ ²		Lymphocyte Cytosolic Protein 2²
SH2 Domain-Containing Leukocyte Protein Of 76 KDa² ³		SH2 Domain-Containing Leukocyte Protein Of 76kD²
SLP-76 Tyrosine Phosphoprotein² ³

External Ids:	HGNC: 6529¹	Entrez Gene: 3937²	Ensembl: ENSG00000043462⁷	OMIM: 601603⁵	UniProtKB: Q13094³

Export aliases for LCP2 gene to outside databases

Previous GC identifers: GC05M169910 GC05M170378 GC05M169610 GC05M169655 GC05M169607 GC05M169675 GC05M164773

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LCP2:

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR)

ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene

structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins

that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that

includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also

contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been

identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the

notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice

have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well

as mast cell and platelet function. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LCP2_HUMAN, Q13094

Function: Involved in T-cell antigen receptor mediated signaling

Gene Wiki entry for LCP2 (Lymphocyte cytosolic protein 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LCP2 gene promoter:
HOXA9 HOXA9B AML1a Bach2 Nkx2-2 FOXD3 Meis-1b Pax-4a Meis-1 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LCP2 promoter sequence

Search SABiosciences Chromatin IP Primers for LCP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q35.1

LCP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LCP2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M169673: view genomic region (about GC identifiers)

Start:	169,673,241 bp from pter	End:	169,725,231 bp from pter
Size:	51,991 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LCP2_HUMAN, Q13094 (See protein sequence)

Recommended Name: Lymphocyte cytosolic protein 2

Size: 533 amino acids; 60188 Da

Subunit: Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB.

Interacts with SHB. Interacts with PRAM1

Subcellular location: Cytoplasm (Probable)

4 PDB 3D structures from and Proteopedia for LCP2:

1H3H (3D)

1YWO (3D)

2EAP (3D)

2ROR (3D)

Secondary accessions: Q53XV4

Explore the universe of human proteins at neXtProt for LCP2: NX_Q13094

Post-translational modifications:

Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1

preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13094

LCP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005556.1

ENSEMBL proteins:

ENSP00000046794 ENSP00000428871 ENSP00000430391

Reactome Protein details: Q13094
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals LCP2 Proteins Novus Biologicals LCP2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LCP2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

LCP2 for ontologies About GeneDecksing

LCP2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LCP2
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	OriGene Antibodies (see all 4): LCP2 OriGene Custom Antibody Services for LCP2
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	Novus Biologicals LCP2 Antibodies
	Abcam antibodies for LCP2
	Uscn Antibodies for LCP2
	ThermoFisher Antibody for LCP2

Assay Products for LCP2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LCP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LCP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LCP2 for domains About GeneDecksing

4 InterPro domains/families:

IPR013761 SAM/pointed

IPR001660 SAM

IPR011510 SAM_2

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry Q13094

ProtoNet protein and cluster: Q13094

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001660 Sterile alpha motif SAM

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: LCP2_HUMAN, Q13094

Domain: The SH2 domain mediates interaction with SHB

Similarity: Contains 1 SAM (sterile alpha motif) domain

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LCP2_HUMAN, Q13094

Function: Involved in T-cell antigen receptor mediated signaling

Genatlas biochemistry entry for LCP2:

leukocyte protein 76kDa (SLP-76),expressed in cells of hematopoietic origin,phosphorylated by TCR coupled tyrosine

kinase

miRNA Products:		OriGene 3'-UTR Clone: LCP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LCP2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate LCP2:
		hsa-miR-137
		SwitchGear 3'UTR luciferase reporter plasmid: LCP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LCP2 (see all 7) OriGene shRNA RFP: LCP2 OriGene siRNA: LCP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LCP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LCP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCP2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LCP2 (NM_005565)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LCP2
		Search LifeMap BioReagents cell lines for LCP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCP2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

LCP2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for LCP2:

Decreased Tat-dependent transc

Decreased p24 protein expressi

Decreased telomerase activity

Animal Models:
Mouse knock-outs for LCP2: Lcp2^tm1Geha Lcp2^tm1.1Wz Lcp2^tm1Gak
8 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Lcp2):

cellular	digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system
liver/biliary system	mortality/aging	respiratory system

LCP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PKC-Theta Pathway

	PKC-Theta Pathway	1.00			ITK and TCR Signaling	0.54
	TCR Signaling	0.68			Fc-EpsilonRI Pathway	0.42

Immune response Fc epsilon RI pathway

	Immune response Fc epsilon RI pathway	1.00			Fc-epsilon receptor I signaling in mast cells	0.33
	Immune response_Fc epsilon RI pathway	0.99

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

Immune response_NFAT in immune response

Immune response_NFAT in immune response

1.00

Immune response NFAT in immune response

0.91

Immune response_ICOS pathway in T-helper cell

Immune response_ICOS pathway in T-helper cell

1.00

Immune response ICOS pathway in T-helper cell

0.91

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for LCP2 (see all 6)

	Immune response CD28 signaling
	Immune response NFAT in immune response
	Immune response Fc epsilon RI pathway
	Immune response ICOS pathway in T-helper cell
	G-protein signaling Regulation of RAC1 activity

5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LCP2 (see all 12)

	ICos-ICosL Pathway in T-Helper Cell
	Rap1 Pathway
	CD28 Signaling in T-Helper Cell
	Tec Kinases Signaling
	CTLA4 Signaling

2 Cell Signaling Technology (CST) Pathways for LCP2

	Lymphocyte Signaling
	Tyrosine Kinases / Adaptors

5/6 GeneGo (Thomson Reuters) Pathways for LCP2 (see all 6)

	G-protein signaling Regulation of RAC1 activity
	Immune response Fc epsilon RI pathway
	Immune response ICOS pathway in T-helper cell
	Immune response T cell receptor signaling pathway
	Immune response CD28 signaling

5 BioSystems Pathways for LCP2

	B Cell Receptor Signaling Pathway
	TCR signaling in naive CD4+ T cells
	TCR signaling in naive CD8+ T cells
	Fc-epsilon receptor I signaling in mast cells
	JNK signaling in the CD4+ TCR pathway

5/12 Reactome Pathways for LCP2 (see all 12)

	Hemostasis
	Adaptive Immune System
	GPVI-mediated activation cascade
	SLP-76 stimulates PLC gamma 2
	DAP12 interactions

4 Kegg Pathways (Kegg details for LCP2):

	Osteoclast differentiation
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway
	Fc epsilon RI signaling pathway

LCP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LCP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/101 Interacting proteins for LCP2 (Q13094^{1, 2, 3} ENSP00000046794⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 101)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCK1	P16333²^,³, ENSP00000288986⁴	MINT-7995411 MINT-7995531 MINT-7995426 MINT-7995458 MINT-8029667 MINT-7995504 MINT-8224277 MINT-7306527 MINT-7995396 MINT-7995442 MINT-8037396 MINT-7995380 MINT-7995488 MINT-7995474 I2D: score=7 STRING: ENSP00000288986
VAV1	P15498²^,³, ENSP00000302269⁴	MINT-8037365 MINT-8029636 MINT-8029651 MINT-8029682 MINT-8224277 MINT-8037350 MINT-8037411 MINT-8037380 MINT-8029621 I2D: score=7 STRING: ENSP00000302269
GRAP2	O75791²^,³, ENSP00000339186⁴	MINT-4302429 MINT-7306546 MINT-4302374 MINT-4302356 MINT-4302410 MINT-7041321 MINT-4302332 MINT-4302391 MINT-4302284 I2D: score=10 STRING: ENSP00000339186
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-4302482 MINT-4302502 MINT-7306677 MINT-7306559 MINT-7306657 I2D: score=6 STRING: ENSP00000339007
PLCG1	P19174²^,³, ENSP00000244007⁴	MINT-7306637 MINT-8224277 MINT-7306572 I2D: score=4 STRING: ENSP00000244007

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	7706237
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	7706237
GO:0007596	blood coagulation	TAS	--
GO:0030168	platelet activation	TAS	--
GO:0045576	mast cell activation	IEA	--

LCP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LCP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LCP2
10/11 Novoseek chemical compound relationships for LCP2 gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	74.1	100	10026222 (6), 8892604 (3), 16456002 (3), 9716598 (3) (see all 57)
phosphotyrosine	38.1	3	12356870 (1), 15699116 (1), 16479002 (1)
phosphoinositide	19	6	11090061 (4), 15388330 (1)
calcium	17.2	10	16479002 (2), 12356870 (1), 10934198 (1), 15699116 (1) (see all 8)
fibrinogen	12.3	6	11050236 (3), 11113155 (2), 11940607 (1)
lipid	2.36	5	12670393 (1), 12356870 (1), 16919152 (1), 15699116 (1) (see all 5)
threonine	0	1	8666952 (1)
phosphatidylinositol	0	2	12670393 (1), 9195899 (1)
proline	0	1	8666952 (1)
serine	0	2	17353368 (1), 8666952 (1)

Search CenterWatch for drugs/clinical trials and news about LCP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LCP2 gene:

NM_005565.3

Unigene Cluster for LCP2:

Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

Hs.304475 [show with all ESTs]

Unigene Representative Sequence: NM_005565

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000046794(uc011des.1 uc003man.1 uc011det.1 uc010jjo.1)

ENST00000520322 ENST00000521416 ENST00000523369 ENST00000520344 ENST00000519594

ENST00000522760 ENST00000522823 ENST00000519149

miRNA Products:		OriGene 3'-UTR Clone: LCP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LCP2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate LCP2:
		hsa-miR-137
		SwitchGear 3'UTR luciferase reporter plasmid: LCP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LCP2 (see all 7) OriGene shRNA RFP: LCP2 OriGene siRNA: LCP2
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		GenScript: all cDNA clones in your preferred vector: LCP2 (NM_005565)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCP2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LCP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCP2

Additional cDNA sequence:

AK122637.1 AK292890.1 AK296098.1 AK300000.1 AK310369.1 BC016618.1 BT007273.1 FN432830.1

U20158.1

10 DOTS entries:

DT.414143 DT.208285 DT.75193588 DT.100755390 DT.414145 DT.91807669 DT.97838721 DT.99963570

DT.120798303 DT.40274855

24/94 AceView cDNA sequences (see all 94):

CA414205 BI835477 AA770606 AI804386 NM_005565 D62832 AW204380 BI030866

BG057319 AA937429 AI033178 AA344958 BF196815 BI831193 BF476782 BU632106

CD520413 BC016618 BT007273 AW768566 N52958 CD523049 BM966863 BG255693

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LCP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

LCP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LCP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LCP2

SOURCE GeneReport for Unigene cluster: Hs.304475

UniProtKB/Swiss-Prot: LCP2_HUMAN, Q13094

Tissue specificity: Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell

and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell

lines

SABiosciences Custom PCR Arrays for LCP2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LCP2 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lcp2^{1 , 5}	lymphocyte cytosolic protein 2^{1, 5}	84.57(n)¹ 84.63(a)¹		11 (19.43 cM)⁵ 16822¹ NM_010696.3¹ NP_034826.2¹ 34046920⁵
chicken (Gallus gallus)	Aves	LCP2¹	lymphocyte cytosolic protein 2 (SH2 domain containing more	65.38(n) 59.62(a)		395438 NM_204701.1 NP_990032.1
lizard (Anolis carolinensis)	Reptilia	LCP2⁶	--	50(a)	1 ↔ 1	2(120665280-120707567)
zebrafish (Danio rerio)	Actinopterygii	zgc:101809¹	zgc:101809	50.73(n) 44.07(a)		336073 NM_214717.1 NP_999882.1

ENSEMBL Gene Tree for LCP2 (if available)
TreeFam Gene Tree for LCP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LCP2 gene

BLNK² CLNK² SH2D6²

1 SIMAP similar gene for LCP2 using alignment to 6 protein entries: LCP2_HUMAN (see all proteins):

CLNK

LCP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182962121^1,2		--	169674629(+)	`AAGTGA/CTATTT`	1	--	ds500¹		0	--	--	--	--
rs185990299^1,2		--	169674887(+)	`TGATGA/GTTGGT`	1	--	ds500¹		0	--	--	--	--
rs190315279^1,2		--	169674934(+)	`CCAGAC/TGTGTT`	1	--	ds500¹		0	--	--	--	--
rs115807981^1,2		--	169674941(+)	`TGTTCA/GTTAAA`	1	--	ds500¹		1		WA	118
rs75457953^1,2	C	--	169674957(+)	`ACCCAC/GGATAC`	1	--	ds500¹		0	--	--	--	--
rs79521188^1,2	C	--	169674958(+)	`CCCACG/TATACA`	1	--	ds500¹		0	--	--	--	--
rs10045290^1,2	C,F,H,	--	169675146(+)	`TTCATA/TAAAAA`	1	--	ut3¹		7		NS EA WA	656
rs10039796^1,2	C,F,A,H,	--	169675165(+)	`AAAATG/CCCCCC`	1	--	ut3¹		10		NS EA NA WA	778
rs117623382^1,2		--	169675318(+)	`AAACAA/GATCAG`	1	--	ut3¹		1		EA	120
rs182816176^1,2		--	169675449(+)	`AATTAC/TTACAG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LCP2 (169673241 - 169725231 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LCP2: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LCP2 for disorders           About GeneDecksing

OMIM gene information: 601603    OMIM disorders: --

9 diseases for LCP2:    About MalaCards

wiskott-aldrich syndrome systemic lupus erythematosus acute promyelocytic leukemia lupus erythematosus

agammaglobulinemia lymphedema leukemia cholesterol

neuroblastoma

4 Novoseek disease relationships for LCP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	36.6	1	11739662 (1)
leukemia t-cell	20.1	3	17178387 (2), 12496421 (1)
lymphoma t-cell	11.8	1	14984504 (1)
bleeding	0	1	11050236 (1)

Human Genome Epidemiology (HuGE) Navigator: LCP2 (4 documents)

Export disorders for LCP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LCP2 gene, integrated from 9 sources (see all 195):
(articles sorted by number of sources associating them with LCP2)

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Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. (PubMed id 7706237)^{1, 2, 3} Jackman J.K.... Findell P.R. (1995)
Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. (PubMed id 15388330)^{1, 2, 9} Shim E.K....Lee J.R. (2004)
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. (PubMed id 21725281)^{1, 2} Sela M....Yablonski D. (2011)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells. (PubMed id 12084069)^{1, 2} Lindholm C.K.... Welsh M. (2002)
PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. (PubMed id 11301322)^{1, 2} Moog-Lutz C....Koretzky G. (2001)
Retinoic acid induces expression of SLP-76: expression with c-FMS enhances ERK activation and retinoic acid-induced differentiation/G0 arrest of HL-60 cells. (PubMed id 16439309)^{1, 9} Yen A....Lamkin T.J. (2006)
Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. (PubMed id 11390650)^{1, 9} Yablonski D....Weiss A. (2001)
T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76. (PubMed id 18549800)^{1, 9} Nguyen K....Bunnell S.C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3937	HGNC: 6529	AceView: LCP2	Ensembl:ENSG00000043462	euGenes: HUgn3937
ECgene: LCP2	Kegg: 3937	H-InvDB: LCP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LCP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LCP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LCP2 gene:
Search GeneIP for patents involving LCP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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