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Aliases for LCP1 Gene

Aliases for LCP1 Gene

  • Lymphocyte Cytosolic Protein 1 2 3 4
  • Lymphocyte Cytosolic Protein 1 (L-Plastin) 2 3 5
  • Plastin 2 2 3
  • L-PLASTIN 3 4
  • LC64P 3 4
  • LCP-1 3 4
  • PLS2 3 4
  • L-Plastin (Lymphocyte Cytosolic Protein 1) (LCP-1) (LC64P) 3
  • BA139H14.1 (Lymphocyte Cytosolic Protein 1 (L-Plastin)) 3
  • Lymphocyte Cytosolic Protein-1 (Plasmin) 3
  • Epididymis Secretory Protein Li 37 3
  • HEL-S-37 3
  • CP64 3
  • LPL 3

External Ids for LCP1 Gene

Previous GeneCards Identifiers for LCP1 Gene

  • GC13M044700
  • GC13M040687
  • GC13M045636
  • GC13M044498
  • GC13M045598
  • GC13M046700
  • GC13M027497

Summaries for LCP1 Gene

Entrez Gene Summary for LCP1 Gene

  • Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for LCP1 Gene

LCP1 (Lymphocyte Cytosolic Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Lipoprotein metabolism. GO annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is PLS1.

UniProtKB/Swiss-Prot for LCP1 Gene

  • Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

Gene Wiki entry for LCP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCP1 Gene

Genomics for LCP1 Gene

Regulatory Elements for LCP1 Gene

Promoters for LCP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LCP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LCP1 Gene

Chromosome:
13
Start:
46,125,920 bp from pter
End:
46,211,871 bp from pter
Size:
85,952 bases
Orientation:
Minus strand

Genomic View for LCP1 Gene

Genes around LCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCP1 Gene

Proteins for LCP1 Gene

  • Protein details for LCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13796-PLSL_HUMAN
    Recommended name:
    Plastin-2
    Protein Accession:
    P13796
    Secondary Accessions:
    • B2R613
    • B4DUA0
    • Q5TBN4

    Protein attributes for LCP1 Gene

    Size:
    627 amino acids
    Molecular mass:
    70288 Da
    Quaternary structure:
    • Monomer. Interacts with AIF1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for LCP1 Gene

    Alternative splice isoforms for LCP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCP1 Gene

Proteomics data for LCP1 Gene at MOPED

Post-translational modifications for LCP1 Gene

  • Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.
  • Ubiquitination at Lys 76, Lys 82, Lys 88, Lys 97, Lys 165, Lys 285, Lys 297, Lys 361, Lys 434, Lys 468, Lys 472, Lys 542, Lys 584, and Lys 610
  • Modification sites at PhosphoSitePlus

Other Protein References for LCP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LCP1 (L-plastin)

No data available for DME Specific Peptides for LCP1 Gene

Domains & Families for LCP1 Gene

Gene Families for LCP1 Gene

Suggested Antigen Peptide Sequences for LCP1 Gene

Graphical View of Domain Structure for InterPro Entry

P13796

UniProtKB/Swiss-Prot:

PLSL_HUMAN :
  • Contains 2 actin-binding domains.
Domain:
  • Contains 2 actin-binding domains.
  • Contains 4 CH (calponin-homology) domains.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with LCP1: view

Function for LCP1 Gene

Molecular function for LCP1 Gene

GENATLAS Biochemistry:
lymphocyte cytosolic protein 1,plastin L,64kDa,actin binding protein,expressed in hemopoietic cells,overexpressed in tumerogenesis,involved in translocation t(3;13)(q27;q14) in B cell non-Hodgkin lymphoma,also involved in other translocations with acute myeloid leukemia
UniProtKB/Swiss-Prot Function:
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

Gene Ontology (GO) - Molecular Function for LCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IMP 16636079
genes like me logo Genes that share ontologies with LCP1: view
genes like me logo Genes that share phenotypes with LCP1: view

Animal Models for LCP1 Gene

MGI Knock Outs for LCP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LCP1 Gene

Localization for LCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCP1 Gene

Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Associated with the actin cytoskeleton at membrane ruffles. Relocalizes to actin-rich cell projections upon serine phosphorylation (PubMed:16636079). {ECO:0000250 UniProtKB:Q61233, ECO:0000269 PubMed:16636079, ECO:0000269 PubMed:17294403}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCP1 Gene COMPARTMENTS Subcellular localization image for LCP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for LCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber IMP 16636079
GO:0001891 phagocytic cup IEA --
GO:0002102 podosome IDA 24236012
GO:0005737 cytoplasm NAS 2378651
GO:0005829 cytosol IDA 2111166
genes like me logo Genes that share ontologies with LCP1: view

Pathways & Interactions for LCP1 Gene

genes like me logo Genes that share pathways with LCP1: view

SIGNOR curated interactions for LCP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022617 extracellular matrix disassembly IMP 24236012
GO:0051017 actin filament bundle assembly IMP 16636079
GO:0071803 positive regulation of podosome assembly IMP 24236012
genes like me logo Genes that share ontologies with LCP1: view

Drugs & Compounds for LCP1 Gene

(6) Drugs for LCP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for LCP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LCP1: view

Transcripts for LCP1 Gene

Unigene Clusters for LCP1 Gene

Lymphocyte cytosolic protein 1 (L-plastin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LCP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7: - -

ExUns: 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for LCP1 Gene

GeneLoc Exon Structure for
LCP1
ECgene alternative splicing isoforms for
LCP1

Expression for LCP1 Gene

mRNA expression in normal human tissues for LCP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCP1 Gene

This gene is overexpressed in Whole Blood (x32.4).

Protein differential expression in normal tissues from HIPED for LCP1 Gene

This gene is overexpressed in NK cells (9.5), Tlymphocyte (8.2), and Monocytes (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LCP1 Gene



SOURCE GeneReport for Unigene cluster for LCP1 Gene Hs.381099

mRNA Expression by UniProt/SwissProt for LCP1 Gene

P13796-PLSL_HUMAN
Tissue specificity: Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
genes like me logo Genes that share expression patterns with LCP1: view

Protein tissue co-expression partners for LCP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LCP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LCP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCP1 36
  • 100 (a)
OneToOne
LCP1 35
  • 99.52 (n)
  • 99.84 (a)
cow
(Bos Taurus)
Mammalia LCP1 35
  • 90.38 (n)
  • 95.85 (a)
LCP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LCP1 36
  • 98 (a)
OneToOne
LCP1 35
  • 91.92 (n)
  • 98.25 (a)
mouse
(Mus musculus)
Mammalia Lcp1 35
  • 89.47 (n)
  • 96.97 (a)
Lcp1 16
Lcp1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LCP1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCP1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lcp1 35
  • 89.42 (n)
  • 96.33 (a)
chicken
(Gallus gallus)
Aves LCP1 35
  • 80.01 (n)
  • 88.65 (a)
LCP1 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia lcp1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lcp1 35
  • 78.47 (n)
  • 86.06 (a)
Str.15364 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10445 35
zebrafish
(Danio rerio)
Actinopterygii lcp1 36
  • 82 (a)
OneToOne
lcp1 35
  • 74.09 (n)
  • 82.37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004071 35
  • 55.94 (n)
  • 55.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fim 35
  • 55.83 (n)
  • 55.56 (a)
Fim 37
  • 53 (a)
Fim 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y104H12BL.1 37
  • 51 (a)
Y104H12BR.1 37
  • 57 (a)
Y73B3B.1 37
  • 55 (a)
plst-1 35
  • 56.5 (n)
  • 55.81 (a)
plst-1 36
  • 51 (a)
ManyToMany
Y73B3B.1 36
  • 34 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR069C 35
  • 51.47 (n)
  • 43.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC6 35
  • 49.24 (n)
  • 41.99 (a)
SAC6 36
  • 37 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19778g 35
  • 50.08 (n)
  • 42.18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04750 35
  • 51.72 (n)
  • 42.37 (a)
rice
(Oryza sativa)
Liliopsida Os02g0588300 35
  • 52.93 (n)
  • 42.7 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03992 35
  • 51.33 (n)
  • 43.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fim1 35
  • 51.91 (n)
  • 44.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8022 36
  • 50 (a)
OneToMany
Species with no ortholog for LCP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LCP1 Gene

ENSEMBL:
Gene Tree for LCP1 (if available)
TreeFam:
Gene Tree for LCP1 (if available)

Paralogs for LCP1 Gene

Paralogs for LCP1 Gene

(2) SIMAP similar genes for LCP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LCP1: view

Variants for LCP1 Gene

Sequence variations from dbSNP and Humsavar for LCP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2093707 -- 46,140,750(-) ccata(G/T)ctgtc intron-variant
rs1886039 -- 46,149,580(-) GGAGA(C/T)GTCTT intron-variant
rs1886040 -- 46,149,459(-) AACCC(A/G)GGGCA intron-variant
rs2146891 -- 46,170,010(-) AATGG(A/T)AACAG intron-variant, upstream-variant-2KB
rs1886045 -- 46,154,448(-) GAAAA(A/G)CGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LCP1 Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073
dgv1579n71 CNV Gain 21882294
nsv832598 CNV Gain 17160897
dgv1580n71 CNV Gain 21882294
nsv455876 CNV Gain 19166990
esv2470452 CNV Deletion 19546169
esv2001689 CNV Deletion 18987734
esv2747356 CNV Deletion 23290073
nsv900059 CNV Gain 21882294
esv271585 CNV Insertion 20981092
nsv819363 CNV Loss 19587683
nsv526925 CNV Loss 19592680

Variation tolerance for LCP1 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCP1 Gene

HapMap Linkage Disequilibrium report
LCP1
Human Gene Mutation Database (HGMD)
LCP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCP1 Gene

Disorders for LCP1 Gene

UniProtKB/Swiss-Prot

PLSL_HUMAN
  • Note=Chromosomal aberrations involving LCP1 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;13)(q27;q14), with BCL6. {ECO:0000269 PubMed:10469447}.

Relevant External Links for LCP1

Genetic Association Database (GAD)
LCP1
Human Genome Epidemiology (HuGE) Navigator
LCP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCP1

No disorders were found for LCP1 Gene.

No data available for MalaCards and Genatlas for LCP1 Gene

Publications for LCP1 Gene

  1. Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. (PMID: 2111166) Zu Y. … Namba Y. (Biochemistry 1990) 2 3 4 67
  2. Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over. (PMID: 20169155) Al Tanoury Z. … Friederich E. (PLoS ONE 2010) 3 23
  3. Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain. (PMID: 20183869) Le Goff E. … Lebart M.C. (Cytoskeleton (Hoboken) 2010) 3 23
  4. Quantitative proteomic analysis of differential proteins in the stroma of nasopharyngeal carcinoma and normal nasopharyngeal epithelial tissue. (PMID: 19142861) Li M.X. … Chen Z.C. (J. Cell. Biochem. 2009) 3 23
  5. Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25. (PMID: 17294403) Wabnitz G.H. … Samstag Y. (Eur. J. Immunol. 2007) 3 23

Products for LCP1 Gene

Sources for LCP1 Gene

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