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Aliases for LCP1 Gene

Aliases for LCP1 Gene

  • Lymphocyte Cytosolic Protein 1 2 3 4 5
  • L-PLASTIN 3 4
  • LC64P 3 4
  • LCP-1 3 4
  • PLS2 3 4
  • L-Plastin (Lymphocyte Cytosolic Protein 1) (LCP-1) (LC64P) 3
  • BA139H14.1 (Lymphocyte Cytosolic Protein 1 (L-Plastin)) 3
  • Lymphocyte Cytosolic Protein 1 (L-Plastin) 2
  • Lymphocyte Cytosolic Protein-1 (Plasmin) 3
  • Epididymis Secretory Protein Li 37 3
  • Plastin 2 2
  • Plastin-2 3
  • HEL-S-37 3
  • CP64 3
  • LPL 3

External Ids for LCP1 Gene

Previous GeneCards Identifiers for LCP1 Gene

  • GC13M044700
  • GC13M040687
  • GC13M045636
  • GC13M044498
  • GC13M045598
  • GC13M046700
  • GC13M027497

Summaries for LCP1 Gene

Entrez Gene Summary for LCP1 Gene

  • Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for LCP1 Gene

LCP1 (Lymphocyte Cytosolic Protein 1) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling. GO annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is PLS3.

UniProtKB/Swiss-Prot for LCP1 Gene

  • Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

Gene Wiki entry for LCP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCP1 Gene

Genomics for LCP1 Gene

Regulatory Elements for LCP1 Gene

Enhancers for LCP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G046163 1.7 FANTOM5 ENCODE dbSUPER 21.3 +37.1 37075 21.8 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A ZNF2 YY1 ZNF766 ZNF143 FOS LCP1 RNU2-6P RUBCNL LRRC63 TPT1-AS1 ZC3H13 RN7SL288P LOC105370192
GH13G046403 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.5 -192.9 -192870 2.3 CTCF PKNOX1 RFX1 ZNF341 MAX ETV6 MYC SPI1 OR7E101P LCP1 RNU2-6P LINC01198 RUBCNL ZC3H13 GC13P046411 GC13P046380
GH13G046159 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +50.8 50817 3.1 CTCF PKNOX1 MAX RAD21 YY1 POLR2A ZNF143 SMC3 MIXL1 STAT1 LCP1 RUBCNL ZC3H13 RN7SL288P ENSG00000278937
GH13G046293 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.5 -83.9 -83932 4.8 RAD21 YY1 ZNF766 GATA2 FOS CEBPB USF2 ZEB2 TBX21 NR2F2 LCP1 LINC01198 RUBCNL ZC3H13 LINC00563 GC13P046277
GH13G046354 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.5 -143.2 -143180 1.8 FOXA2 ATF1 CBX5 ZNF143 RCOR1 FOS ETV6 IKZF2 CBFB USF2 LINC01198 LCP1 RUBCNL GC13M046284 GC13M046376 RNU2-6P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LCP1 on UCSC Golden Path with GeneCards custom track

Promoters for LCP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000062374 271 1201 PKNOX1 ATF1 CREB3L1 ARNT TCF12 GLIS2 ZNF143 KLF7 NCOA1 REST

Genomic Location for LCP1 Gene

Chromosome:
13
Start:
46,125,920 bp from pter
End:
46,211,871 bp from pter
Size:
85,952 bases
Orientation:
Minus strand

Genomic View for LCP1 Gene

Genes around LCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCP1 Gene

Proteins for LCP1 Gene

  • Protein details for LCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13796-PLSL_HUMAN
    Recommended name:
    Plastin-2
    Protein Accession:
    P13796
    Secondary Accessions:
    • B2R613
    • B4DUA0
    • Q5TBN4

    Protein attributes for LCP1 Gene

    Size:
    627 amino acids
    Molecular mass:
    70288 Da
    Quaternary structure:
    • Monomer. Interacts with AIF1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for LCP1 Gene

    Alternative splice isoforms for LCP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCP1 Gene

Post-translational modifications for LCP1 Gene

  • Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.
  • Ubiquitination at isoforms=76, posLast=8282, posLast=8888, isoforms=97, isoforms=165, isoforms=285, posLast=297297, isoforms=361, isoforms=434, posLast=468468, isoforms=2472, posLast=542542, posLast=584584, and posLast=610610
  • Modification sites at PhosphoSitePlus

Other Protein References for LCP1 Gene

No data available for DME Specific Peptides for LCP1 Gene

Domains & Families for LCP1 Gene

Gene Families for LCP1 Gene

Suggested Antigen Peptide Sequences for LCP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LCP1: view

No data available for UniProtKB/Swiss-Prot for LCP1 Gene

Function for LCP1 Gene

Molecular function for LCP1 Gene

GENATLAS Biochemistry:
lymphocyte cytosolic protein 1,plastin L,64kDa,actin binding protein,expressed in hemopoietic cells,overexpressed in tumerogenesis,involved in translocation t(3;13)(q27;q14) in B cell non-Hodgkin lymphoma,also involved in other translocations with acute myeloid leukemia
UniProtKB/Swiss-Prot Function:
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

Gene Ontology (GO) - Molecular Function for LCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS 2252891
GO:0005509 calcium ion binding NAS 2378651
GO:0042802 identical protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051015 actin filament binding IMP 16636079
genes like me logo Genes that share ontologies with LCP1: view
genes like me logo Genes that share phenotypes with LCP1: view

Animal Models for LCP1 Gene

MGI Knock Outs for LCP1:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LCP1 Gene

Localization for LCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCP1 Gene

Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Associated with the actin cytoskeleton at membrane ruffles. Relocalizes to actin-rich cell projections upon serine phosphorylation (PubMed:16636079). {ECO:0000250 UniProtKB:Q61233, ECO:0000269 PubMed:16636079, ECO:0000269 PubMed:17294403}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCP1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for LCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber IMP 16636079
GO:0001726 ruffle IMP 16636079
GO:0001891 phagocytic cup IEA --
GO:0002102 podosome IDA 24236012
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with LCP1: view

Pathways & Interactions for LCP1 Gene

SuperPathway Contained pathways
1 NF-kappaB Signaling
genes like me logo Genes that share pathways with LCP1: view

Pathways by source for LCP1 Gene

1 Cell Signaling Technology pathway for LCP1 Gene

SIGNOR curated interactions for LCP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IDA 17294403
GO:0010737 protein kinase A signaling IMP 16636079
GO:0016477 cell migration IMP 16636079
GO:0022617 extracellular matrix disassembly IMP 24236012
GO:0031100 animal organ regeneration IEA --
genes like me logo Genes that share ontologies with LCP1: view

Drugs & Compounds for LCP1 Gene

(7) Drugs for LCP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for LCP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LCP1: view

Transcripts for LCP1 Gene

Unigene Clusters for LCP1 Gene

Lymphocyte cytosolic protein 1 (L-plastin):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7: - -

ExUns: 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for LCP1 Gene

GeneLoc Exon Structure for
LCP1
ECgene alternative splicing isoforms for
LCP1

Expression for LCP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCP1 Gene

This gene is overexpressed in Whole Blood (x32.4).

Protein differential expression in normal tissues from HIPED for LCP1 Gene

This gene is overexpressed in NK cells (9.5), Tlymphocyte (8.2), and Monocytes (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LCP1 Gene



Protein tissue co-expression partners for LCP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LCP1 Gene:

LCP1

SOURCE GeneReport for Unigene cluster for LCP1 Gene:

Hs.381099

mRNA Expression by UniProt/SwissProt for LCP1 Gene:

P13796-PLSL_HUMAN
Tissue specificity: Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.

Evidence on tissue expression from TISSUES for LCP1 Gene

  • Blood(4.9)
  • Nervous system(4.5)
  • Liver(4.4)
  • Intestine(3.4)
  • Lymph node(3.4)
  • Lung(3.3)
  • Spleen(3.1)
  • Bone marrow(2.4)
genes like me logo Genes that share expression patterns with LCP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LCP1 Gene

Orthologs for LCP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LCP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCP1 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia LCP1 34 35
  • 91.92 (n)
oppossum
(Monodelphis domestica)
Mammalia LCP1 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCP1 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LCP1 34 35
  • 90.38 (n)
mouse
(Mus musculus)
Mammalia Lcp1 34 16 35
  • 89.47 (n)
rat
(Rattus norvegicus)
Mammalia Lcp1 34
  • 89.42 (n)
chicken
(Gallus gallus)
Aves LCP1 34 35
  • 80.01 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia lcp1 34
  • 78.47 (n)
Str.15364 34
African clawed frog
(Xenopus laevis)
Amphibia lcp1-prov 34
zebrafish
(Danio rerio)
Actinopterygii lcp1 34 35
  • 74.09 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10445 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004071 34
  • 55.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fim 36 34 35
  • 55.83 (n)
worm
(Caenorhabditis elegans)
Secernentea Y104H12BR.1 36
  • 57 (a)
plst-1 34 35
  • 56.5 (n)
Y73B3B.1 36 35
  • 55 (a)
Y104H12BL.1 36
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR069C 34
  • 51.47 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19778g 34
  • 50.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC6 34 35
  • 49.24 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04750 34
  • 51.72 (n)
rice
(Oryza sativa)
Liliopsida Os02g0588300 34
  • 52.93 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fim1 34
  • 51.91 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03992 34
  • 51.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8022 35
  • 50 (a)
OneToMany
Species where no ortholog for LCP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LCP1 Gene

ENSEMBL:
Gene Tree for LCP1 (if available)
TreeFam:
Gene Tree for LCP1 (if available)

Paralogs for LCP1 Gene

Paralogs for LCP1 Gene

(2) SIMAP similar genes for LCP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LCP1: view

Variants for LCP1 Gene

Sequence variations from dbSNP and Humsavar for LCP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000022692 -- 46,164,720(+) CCATC(A/G)GCATG intron-variant
rs1000255814 -- 46,161,801(+) CTACA(A/G)GTAGG intron-variant
rs1000266183 -- 46,174,190(+) GCTTC(C/T)TGGAT intron-variant
rs1000274038 -- 46,161,557(+) CCTCT(C/T)GTCCT intron-variant
rs1000289456 -- 46,137,369(+) CCTGT(C/G/T)TCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LCP1 Gene

Variant ID Type Subtype PubMed ID
dgv223e201 CNV deletion 23290073
esv2001689 CNV deletion 18987734
esv2470452 CNV deletion 19546169
esv2747356 CNV deletion 23290073
esv3307309 CNV mobile element insertion 20981092
esv3324310 CNV insertion 20981092
esv3550413 CNV deletion 23714750
esv3631977 CNV loss 21293372
esv3631978 CNV loss 21293372
nsv1049556 CNV gain 25217958
nsv1051215 CNV gain 25217958
nsv455876 CNV gain 19166990
nsv526925 CNV loss 19592680
nsv561581 CNV gain 21841781
nsv819363 CNV loss 19587683
nsv832598 CNV gain 17160897
nsv951080 CNV duplication 24416366

Variation tolerance for LCP1 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCP1 Gene

Human Gene Mutation Database (HGMD)
LCP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCP1 Gene

Disorders for LCP1 Gene

UniProtKB/Swiss-Prot

PLSL_HUMAN
  • Note=Chromosomal aberrations involving LCP1 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;13)(q27;q14), with BCL6. {ECO:0000269 PubMed:10469447}.

Relevant External Links for LCP1

Genetic Association Database (GAD)
LCP1
Human Genome Epidemiology (HuGE) Navigator
LCP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCP1

No disorders were found for LCP1 Gene.

No data available for MalaCards and Genatlas for LCP1 Gene

Publications for LCP1 Gene

  1. Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25. (PMID: 17294403) Wabnitz G.H. … Samstag Y. (Eur. J. Immunol. 2007) 3 4 22 64
  2. Phosphorylation on Ser5 increases the F-actin-binding activity of L- plastin and promotes its targeting to sites of actin assembly in cells. (PMID: 16636079) Janji B. … Friederich E. (J. Cell Sci. 2006) 3 4 22 64
  3. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. (PMID: 8428952) Lin C.-S. … Leavitt J. (J. Biol. Chem. 1993) 3 4 22 64
  4. Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. (PMID: 2111166) Zu Y. … Namba Y. (Biochemistry 1990) 2 3 4 64
  5. 65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites. (PMID: 2252891) Zu Y. … Namba Y. (Biochemistry 1990) 3 4 22 64

Products for LCP1 Gene

Sources for LCP1 Gene

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