Aliases for LCP1 Gene
External Ids for LCP1 Gene
Previous GeneCards Identifiers for LCP1 Gene
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]
GeneCards Summary for LCP1 Gene
LCP1 (Lymphocyte Cytosolic Protein 1 (L-Plastin)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Developmental Biology. GO annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is PLS3.
UniProtKB/Swiss-Prot for LCP1 Gene
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.