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LCP1 Gene

protein-coding GIFtS: 60

GC13M045598

lymphocyte cytosolic protein 1 (L-plastin)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CP64 ^¹, ²
DKFZp781A23186 ^²
FLJ25423 ^²
FLJ26114 ^²
FLJ39956 ^²
L-PLASTIN ^¹, ²
L-plastin ^², ³
LC64P ^¹, ², ³
LCP-1 ^³
LPL ^²
OTTHUMP00000018362 ^²
PLS2 ^¹, ², ³

Descriptions
L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P) ^²
Lymphocyte cytosolic protein 1 ^³
Lymphocyte cytosolic protein-1 (plasmin) ^²
bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)) ^²
lymphocyte cytosolic protein 1 (L-plastin) ^²
plastin 2 ^²

External Ids
HGNC: 6528¹
Entrez Gene: 3936²
UniProtKB: P13796³
Ensembl: ENSG00000136167⁷

Search outside databases for aliases for LCP1 gene

Previous GC identifers: GC13M044700 GC13M040687 GC13M045636 GC13M044498

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LCP1:

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution

and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L

and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin

isoform which is specifically expressed at high levels in the small intestine. The L isoform is

expressed only in hemopoietic cell lineages, while the T isoform has been found in all other

normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells,

epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant

human cells of non-hemopoietic origin suggesting that its expression is induced accompanying

tumorigenesis in solid tissues. [provided by RefSeq]

UniProtKB/Swiss-Prot: PLSL_HUMAN, P13796

Function: Actin-binding protein found in intestinal microvilli, hair cell stereocilia, and

fibroblast filopodia

Gene Wiki entry for LCP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LCP1 gene

Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.12 HGNC cytogenetic band: 13q14.3

LCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M045598: (about GC identifiers)

Start:	45,598,060 bp from pter
End:	45,683,484 bp from pter
Size:	85,425 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PLSL_HUMAN, P13796 (See protein sequence)

Recommended Name: Plastin-2

Size: 627 amino acids; 70289 Da

Subunit: Monomer

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

2D85 (3D)

Secondary accessions: B2R613

Post-translational modifications:

Phosphorylated¹

The N-terminus is blocked¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002289.2

ENSEMBL proteins:

ENSP00000315757 ENSP00000381581

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Plastin L)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IEA	--
GO:0001891	phagocytic cup	IEA	--
GO:0005737	cytoplasm	NAS	2378651
GO:0005829	cytosol	IDA	2111166
GO:0005884	actin filament	IEA	--

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Antibodies for LCP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LCP1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Plastin L), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for LCP1

Assays for LCP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P13796

ProtoNet protein and cluster: P13796

2 Blocks protein families:

IPB001589 Actin-binding

IPB001715 Calponin-like actin-binding

UniProtKB/Swiss-Prot: PLSL_HUMAN, P13796

Similarity: Contains 2 actin-binding domains

Similarity: Contains 4 CH (calponin-homology) domains

Similarity: Contains 2 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LCP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LCP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002298

Applied Biosystems Silencer® siRNAs for LCP1

Sigma-Aldrich siRNA for LCP1

Sigma-Aldrich shRNA for LCP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002298
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002298
untagged cDNA clone in CMV expression vector: NM_002298

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002298

UniProtKB/Swiss-Prot: PLSL_HUMAN, P13796

Function: Actin-binding protein found in intestinal microvilli, hair cell stereocilia, and

fibroblast filopodia

Genatlas biochemistry entry for LCP1:

lymphocyte cytosolic protein 1,plastin L,64kDa,actin binding protein,expressed in hemopoietic

cells,overexpressed in tumerogenesis,involved in translocation t(3;13)(q27;q14) in B cell

non-Hodgkin lymphoma,also involved in other translocations with acute myeloid leukemia

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	NAS	2378651
GO:0042802	identical protein binding	IEA	--
GO:0051015	actin filament binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Interacting proteins for LCP1 (P13796¹ ENSP00000315757³) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN2	Q99700¹	EBI-698036, EBI-697691
GCA	ENSP00000233612³	STRING (score=.987)
LMO2	ENSP00000257818³	STRING (score=.807)
ACTB	ENSP00000349960³	STRING (score=.769)
SPI1	ENSP00000367799³	STRING (score=.728)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--
GO:0051017	actin filament bundle formation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LCP1
7 Novoseek chemical compound relationships for LCP1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cytosine	47.63	4	12719708 (2), 16179927 (1), 17679557 (1)
fmlp	25.65	5	14556648 (5)
progesterone	12.40	6	8012965 (3), 11062740 (1), 8055865 (1)
steroid	5.75	8	16281503 (3), 9176394 (2), 8012965 (1)
calcium	5.32	5	8663066 (2), 8461306 (1), 7897227 (1)
estradiol	0.00	2	8012965 (1), 9176394 (1)
superoxide	0.00	3	14769871 (1), 17320137 (1), 16391823 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LCP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LCP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002298

Sigma-Aldrich siRNA for LCP1

Sigma-Aldrich shRNA for LCP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002298

REFSEQ mRNAs for LCP1 gene:

NM_002298.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002298

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002298
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002298
                                 untagged cDNA clone in CMV expression vector: NM_002298

Additional cDNA sequence:

AB208984.1 AK058152.1 AK093568.1 AK097174.1 AK097275.1 AK129625.1 AK223305.1 AK300556.1

AK309009.1 AK312393.1 AY960627.3 BC007673.1 BC010271.1 BC015001.1 BC053839.1 CR593418.1

CR936795.1 J02923.1 M22300.1 M34426.1

24/33 DOTS entries (see all 33 ):

DT.418819 DT.95226164 DT.95317085 DT.100656064 DT.100656072 DT.100804311 DT.100656067 DT.100031383

DT.101984525 DT.100830729 DT.92464039 DT.120773322 DT.97862431 DT.97817205 DT.101976482 DT.120773270

DT.120773310 DT.120773329 DT.92464082 DT.95317150 DT.97775295 DT.100061002 DT.100656071 DT.100774306

24/713 AceView cDNA sequences (see all 713 ):

BX361599 AL043695 AW401986 AW467876 CN479414 BQ065013 AU076720 W79358

AA156857 BX443732 BU164563 AI499994 AA707091 AU136291 BQ436063 AW403332

BI093518 BM454253 BM465025 BE858569 BQ229636 BQ433642 BU431561 BM479779

highest scoring ESTs for LCP1:

J02923 AA312169 AA346505 AA346507 AK093568 AL601737 AU076720 AU100436 AV759230 AW502859

Unigene Cluster for LCP1:

Lymphocyte cytosolic protein 1 (L-plastin)

Hs.381099 [show with all ESTs]

Unigene Representative Sequence: NM_002298

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LCP1 (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^
SP1:									-		-				-		-								-														-								-
SP2:																																															-
SP3:									-		-				-		-
SP4:											-				-		-
SP5:

ExUns:	19a	·	19b	·	19c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LCP1

2 Ensembl transcripts including schematic representations:

ENST00000323076 ENST00000398576

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LCP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LCP1

¹ / ² / ³

3 probe-sets matching LCP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37023_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	J02923	1.00	0.90	0.95	1
208885_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J02923	1.00	0.90	0.95	1
208885_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LCP1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGCTCCTCC

SOURCE GeneReport for Unigene cluster: Hs.381099
Expression variation in blood from EXPOLDB for LCP1
UniProtKB/Swiss-Prot: PLSL_HUMAN, P13796
Tissue specificity: Restricted to the spleen and other lymph node-containing organs. Expressed in
neutrophils, monocytes, B lymphocytes, and myeloid cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LCP1 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LCP1¹	--	lymphocyte cytosolic protein 1 (L-plastin)	91.09(n) 97.29(a)	476921 XM_534124.2 XP_534124.2
chimpanzee (Pan troglodytes)	LCP1¹	--	lymphocyte cytosolic protein 1 (L-plastin)	99.57(n) 100(a)	452583 XM_001157345.1 XP_001157345.1
cow (Bos taurus)	LCP1¹	--	lymphocyte cytosolic protein 1 (L-plastin)	90.43(n) 96.01(a)	540990 NM_001034720.1 NP_001029892.1
rat (Rattus norvegicus)	Lcp1¹	--	lymphocyte cytosolic protein 1	89.42(n) 96.33(a)	306071 NM_001012044.1 NP_001012044.1
mouse (Mus musculus)	Lcp1^{1, 5}	14 (42.00 cM)⁵	lymphocyte cytosolic protein 1^{1, 5}	89.47(n)¹ 96.97(a)¹	18826¹ NM_008879.3¹ NP_032905.2¹ AK009211⁵ AK030806⁵ (see all 35)

About this table Species with no ortholog for LCP1

ENSEMBL Gene Tree for LCP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for LCP1 gene

PLS1² PLS3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/405 NCBI SNPs in LCP1 are shown (see all 405 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 181)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1409430^1,2	A,C,F,H,O	45599234(-)	`CTCCCA/TTGACT`	1	--	ut3¹ ese³		8	MN NA EU EA WA	742
--	rs1409429^1,2	A,C,F,H,O	45599372(-)	`GCTTCA/TTGTGG`	1	--	ut3¹		9	MN EA NA EU WA	2222
	rs2224777^1,2	A,C,F,H,O	45656066(-)	`CAGAAC/TACTGT`	1	--	ng3¹		12	EA NA EU WA	2072
	rs3759490^1,2	A,C,F,H	45656147(+)	`GTTCAG/ACAAGT`	1	--	ng3¹		7	NA EU EA WA	538
--	rs11619963^1,2	A,C,F,H	45597634(+)	`tagtaC/Ttggcc`	1	--	ng5¹		3	EU EA	300
	rs4941543^1,2	A,C,F,H	45606292(+)	`TTTCTC/TTGCTT`	1	K/E	mis¹		12	NA EU EA WA	1050
	rs3759483^1,2	A,C,F,H	45655198(-)	`ATGCTC/GCATTT`	1	--	ng3¹		17	EA NS NA MN EU WA	2686
	rs4391952^1,2	A,C,F,H	45599175(+)	`GGACGG/CCCAGA`	1	--	ut3¹		7	EU EA WA NA	556
	rs12583876^1,2	A,C,F,H	45598063(+)	`ATATAG/AGGAAC`	1	--	ut3¹ ese³		8	EU EA WA	824
	rs11342^1,2	A,C,F,H	45598643(-)	`GGGGAC/AAATAT`	1	--	ut3¹ ese³		12	MN NA EU EA WA	1154

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HapMap Linkage Disequilibrium images for LCP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 153430

10/14 Novoseek disease relationships for LCP1 gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
solid tumor	31.59	3	8461306 (1), 8012965 (1), 8428952 (1)
cancer	24.30	8	12843666 (2), 12719708 (1), 8428953 (1), 16287074 (1) (see all 6)
fibrosarcoma	22.43	1	8428952 (1)
ovarian cancer	21.66	3	11389068 (2), 10195877 (1)
tumors	21.39	12	17290393 (2), 11062740 (2), 8548753 (2), 17679557 (1) (see all 9)
ovarian carcinoma	15.21	1	8428952 (1)
colon cancer	12.77	2	16287074 (1)
breast carcinoma	3.11	1	8428952 (1)
shock	0.00	2	12949081 (1), 15749383 (1)
melanoma	0.00	6	17290393 (6)

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1 PharmGKB disease relationship for LCP1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/101 PubMed articles for LCP1 gene (see all 101 ):

Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. (PubMed id 2111166)^{2, 3, 4} Zu Y.... Namba Y. (1990)
Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. (PubMed id 8428952)^{1, 3, 4} Lin C.-S.... Leavitt J. (1993)
65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites. (PubMed id 2252891)^{1, 3, 4} Zu Y....Namba Y. (1990)
Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain. (PubMed id 2378651)^{1, 3, 4} Lin C.-S.... Leavitt J. (1990)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1. (PubMed id 3261603)^{3, 4} Matsushima K.... Copeland T.D. (1988)
Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts. (PubMed id 3211125)^{3, 4} Lin C.-S.... Leavitt J. (1988)
Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells. (PubMed id 17290393)^{1, 3} Klemke M....Samstag Y. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3936	HGNC: 6528	AceView: LCP1	Ensembl:ENSG00000136167	euGenes: HUgn3936
ECgene: LCP1	H-InvDB: LCP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LCP1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for LCP1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for LCP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LCP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LCP1		Antibodies for LCP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LCP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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LCP1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for LCP1

Summaries
for LCP1

Genomic Location
for LCP1

Proteins
for LCP1

Protein Domains/
Families
for LCP1

Gene Function
for LCP1

Pathways & Interactions
for LCP1

Drugs & Compounds
for LCP1

Transcripts
for LCP1

Expression
for LCP1

Orthologs
for LCP1

Paralogs
for LCP1

SNPs/Variants
for LCP1

Disorders & Mutations
for LCP1

Medical News
for LCP1

Publications
for LCP1

Search for LCP1

Genome Databases showing LCP1

Other Databases showing LCP1

Specialized Databases showing LCP1

Licensable Technologies
for LCP1

Services
for LCP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LCP1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor LCP1

Summariesfor LCP1

Genomic Locationfor LCP1

Proteinsfor LCP1

Protein Domains/Familiesfor LCP1

Gene Functionfor LCP1

Pathways & Interactionsfor LCP1

Drugs & Compoundsfor LCP1

Transcriptsfor LCP1

Expression for LCP1

Orthologsfor LCP1

Paralogsfor LCP1

SNPs/Variantsfor LCP1

Disorders & Mutationsfor LCP1

Medical Newsfor LCP1

Publicationsfor LCP1

Search for LCP1

Genome Databases showing LCP1

Other Databases showing LCP1

Specialized Databases showing LCP1

Licensable Technologiesfor LCP1

Servicesfor LCP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LCP1

Summaries
for LCP1

Genomic Location
for LCP1

Proteins
for LCP1

Protein Domains/
Families
for LCP1

Gene Function
for LCP1

Pathways & Interactions
for LCP1

Drugs & Compounds
for LCP1

Transcripts
for LCP1

Expression
for LCP1

Orthologs
for LCP1

Paralogs
for LCP1

SNPs/Variants
for LCP1

Disorders & Mutations
for LCP1

Medical News
for LCP1

Publications
for LCP1

Licensable Technologies
for LCP1

Services
for LCP1