Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LCORL Gene

Aliases for LCORL Gene

  • Ligand Dependent Nuclear Receptor Corepressor Like 2 3 5
  • Ligand-Dependent Nuclear Receptor Corepressor-Like Protein 3
  • Ligand Dependent Nuclear Receptor Corepressor-Like 2
  • Transcription Factor MLR1 3
  • MBLK1-Related Protein 3
  • LCOR-Like Protein 3
  • LCoR-Like Protein 4
  • MLR1 3

External Ids for LCORL Gene

Previous GeneCards Identifiers for LCORL Gene

  • GC04M017453
  • GC04M017199

Summaries for LCORL Gene

Entrez Gene Summary for LCORL Gene

  • This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for LCORL Gene

LCORL (Ligand Dependent Nuclear Receptor Corepressor Like) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LCORL Gene

  • May act as transcription activator that binds DNA elements with the sequence 5-CCCTATCGATCGATCTCTACCT-3. May play a role in spermatogenesis (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCORL Gene

Genomics for LCORL Gene

Regulatory Elements for LCORL Gene

Enhancers for LCORL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G017807 1.4 Ensembl ENCODE 10.5 +210.7 210728 7.6 HNRNPUL1 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 DCAF16 MED28 LCORL NCAPG GC04M017884
GH04G017575 1.5 FANTOM5 ENCODE 9 +443.2 443246 5.3 HDGF PKNOX1 FOXA2 MLX ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 LAP3 MED28 DCAF16 ENSG00000249502 NCAPG QDPR LCORL GC04M017599
GH04G018057 0.8 Ensembl 11.5 -35.7 -35725 0.8 IRF2 ETV1 RBBP5 ZBTB40 ZNF766 EED NFE2 RELB IKZF2 CREM LCORL GC04M018070
GH04G017817 0.7 ENCODE 10.5 +204.6 204644 0.2 HDGF CTCF FOXA2 TRIM22 RAD21 FOXA1 CBX5 ZNF143 SMC3 MLLT1 LCORL NCAPG GC04M017884
GH04G017978 0.3 FANTOM5 13.1 +43.5 43465 0.4 LCORL CLRN2 KRT18P63
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LCORL on UCSC Golden Path with GeneCards custom track

Promoters for LCORL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000166457 376 3401 HDGF FOXA2 PKNOX1 CREB3L1 ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for LCORL Gene

Chromosome:
4
Start:
17,841,199 bp from pter
End:
18,021,876 bp from pter
Size:
180,678 bases
Orientation:
Minus strand

Genomic View for LCORL Gene

Genes around LCORL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCORL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCORL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCORL Gene

Proteins for LCORL Gene

  • Protein details for LCORL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3X6-LCORL_HUMAN
    Recommended name:
    Ligand-dependent nuclear receptor corepressor-like protein
    Protein Accession:
    Q8N3X6
    Secondary Accessions:
    • Q96NK1

    Protein attributes for LCORL Gene

    Size:
    602 amino acids
    Molecular mass:
    66964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LCORL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCORL Gene

Post-translational modifications for LCORL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LCORL Gene

Domains & Families for LCORL Gene

Protein Domains for LCORL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LCORL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LCORL Gene

Function for LCORL Gene

Molecular function for LCORL Gene

UniProtKB/Swiss-Prot Function:
May act as transcription activator that binds DNA elements with the sequence 5-CCCTATCGATCGATCTCTACCT-3. May play a role in spermatogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for LCORL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LCORL: view
genes like me logo Genes that share phenotypes with LCORL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LCORL Gene

Localization for LCORL Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCORL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCORL gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LCORL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LCORL: view

Pathways & Interactions for LCORL Gene

SuperPathways for LCORL Gene

No Data Available

Gene Ontology (GO) - Biological Process for LCORL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with LCORL: view

No data available for Pathways by source and SIGNOR curated interactions for LCORL Gene

Drugs & Compounds for LCORL Gene

No Compound Related Data Available

Transcripts for LCORL Gene

mRNA/cDNA for LCORL Gene

(12) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCORL Gene

Ligand dependent nuclear receptor corepressor-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCORL Gene

No ASD Table

Relevant External Links for LCORL Gene

GeneLoc Exon Structure for
LCORL
ECgene alternative splicing isoforms for
LCORL

Expression for LCORL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCORL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LCORL Gene



NURSA nuclear receptor signaling pathways regulating expression of LCORL Gene:

LCORL

SOURCE GeneReport for Unigene cluster for LCORL Gene:

Hs.446201

Evidence on tissue expression from TISSUES for LCORL Gene

  • Nervous system(4.4)
  • Liver(2)
genes like me logo Genes that share expression patterns with LCORL: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCORL Gene

Orthologs for LCORL Gene

This gene was present in the common ancestor of animals.

Orthologs for LCORL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCORL 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia LCORL 34 35
  • 97.78 (n)
dog
(Canis familiaris)
Mammalia LCORL 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lcorl 34 16 35
  • 95.89 (n)
rat
(Rattus norvegicus)
Mammalia Lcorl 34
  • 95.02 (n)
oppossum
(Monodelphis domestica)
Mammalia LCORL 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCORL 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LCORL 34 35
  • 90.26 (n)
lizard
(Anolis carolinensis)
Reptilia LCORL 35
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lcorl 34
  • 62.18 (n)
wu:fc17b08 35
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Eip93F 35
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mbr-1 35
  • 8 (a)
OneToMany
Species where no ortholog for LCORL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LCORL Gene

ENSEMBL:
Gene Tree for LCORL (if available)
TreeFam:
Gene Tree for LCORL (if available)

Paralogs for LCORL Gene

(1) SIMAP similar genes for LCORL Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for LCORL Gene

genes like me logo Genes that share paralogs with LCORL: view

No data available for Paralogs for LCORL Gene

Variants for LCORL Gene

Sequence variations from dbSNP and Humsavar for LCORL Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000009453 -- 17,919,561(+) CAGTA(C/T)CTATA intron-variant
rs1000013702 -- 18,018,826(+) TTATA(A/G)AAATG intron-variant
rs1000019836 -- 17,899,016(+) TGACA(C/G)GTGTG intron-variant
rs1000035267 -- 17,938,708(+) GCGCC(C/T)GGCCC intron-variant
rs1000044597 -- 17,846,096(+) TGTAA(A/C)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LCORL Gene

Variant ID Type Subtype PubMed ID
esv2544363 CNV deletion 19546169
esv991821 CNV deletion 20482838
nsv477969 CNV novel sequence insertion 20440878
nsv478080 CNV novel sequence insertion 20440878
nsv819053 CNV loss 19587683
nsv980185 CNV duplication 23825009

Variation tolerance for LCORL Gene

Gene Damage Index Score: 3.30; 53.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCORL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCORL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCORL Gene

Disorders for LCORL Gene

Relevant External Links for LCORL

Genetic Association Database (GAD)
LCORL
Human Genome Epidemiology (HuGE) Navigator
LCORL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCORL

No disorders were found for LCORL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCORL Gene

Publications for LCORL Gene

  1. Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). (PMID: 22021425) Carty C.L. … Kooperberg C. (Hum. Mol. Genet. 2012) 3 46 64
  2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 3 46 64
  3. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y. … Kamatani N. (Hum. Mol. Genet. 2010) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Genome-wide association study of height and body mass index in Australian twin families. (PMID: 20397748) Liu J.Z. … McRae A.F. (Twin Res Hum Genet 2010) 3 46 64

Products for LCORL Gene

Sources for LCORL Gene

Content
Loading form....