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Aliases for LCORL Gene

Aliases for LCORL Gene

  • Ligand Dependent Nuclear Receptor Corepressor-Like 2 3
  • Transcription Factor MLR1 3
  • MBLK1-Related Protein 3
  • LCOR-Like Protein 3
  • LCoR-Like Protein 4
  • MLR1 3

External Ids for LCORL Gene

Previous GeneCards Identifiers for LCORL Gene

  • GC04M017453
  • GC04M017199

Summaries for LCORL Gene

Entrez Gene Summary for LCORL Gene

  • This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for LCORL Gene

LCORL (Ligand Dependent Nuclear Receptor Corepressor-Like) is a Protein Coding gene. An important paralog of this gene is LCOR.

UniProtKB/Swiss-Prot for LCORL Gene

  • May act as transcription activator that binds DNA elements with the sequence 5-CCCTATCGATCGATCTCTACCT-3. May play a role in spermatogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCORL Gene

Genomics for LCORL Gene

Regulatory Elements for LCORL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LCORL Gene

Chromosome:
4
Start:
17,841,199 bp from pter
End:
18,021,876 bp from pter
Size:
180,678 bases
Orientation:
Minus strand

Genomic View for LCORL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LCORL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCORL Gene

Proteins for LCORL Gene

  • Protein details for LCORL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3X6-LCORL_HUMAN
    Recommended name:
    Ligand-dependent nuclear receptor corepressor-like protein
    Protein Accession:
    Q8N3X6
    Secondary Accessions:
    • Q96NK1

    Protein attributes for LCORL Gene

    Size:
    602 amino acids
    Molecular mass:
    66964 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LCORL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCORL Gene

Proteomics data for LCORL Gene at MOPED

Post-translational modifications for LCORL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCORL Gene

No data available for DME Specific Peptides for LCORL Gene

Domains & Families for LCORL Gene

Protein Domains for LCORL Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N3X6

UniProtKB/Swiss-Prot:

LCORL_HUMAN :
  • Contains 1 HTH psq-type DNA-binding domain.
Domain:
  • Contains 1 HTH psq-type DNA-binding domain.
genes like me logo Genes that share domains with LCORL: view

No data available for Gene Families for LCORL Gene

Function for LCORL Gene

Molecular function for LCORL Gene

UniProtKB/Swiss-Prot Function:
May act as transcription activator that binds DNA elements with the sequence 5-CCCTATCGATCGATCTCTACCT-3. May play a role in spermatogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for LCORL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LCORL: view

Phenotypes for LCORL Gene

GenomeRNAi human phenotypes for LCORL:
genes like me logo Genes that share phenotypes with LCORL: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LCORL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LCORL Gene

Localization for LCORL Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCORL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCORL Gene COMPARTMENTS Subcellular localization image for LCORL gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LCORL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LCORL: view

Pathways & Interactions for LCORL Gene

SuperPathways for LCORL Gene

No Data Available

Gene Ontology (GO) - Biological Process for LCORL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with LCORL: view

No data available for Pathways by source and SIGNOR curated interactions for LCORL Gene

Drugs & Compounds for LCORL Gene

No Compound Related Data Available

Transcripts for LCORL Gene

mRNA/cDNA for LCORL Gene

(8) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCORL Gene

Ligand dependent nuclear receptor corepressor-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LCORL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCORL Gene

No ASD Table

Relevant External Links for LCORL Gene

GeneLoc Exon Structure for
LCORL
ECgene alternative splicing isoforms for
LCORL

Expression for LCORL Gene

mRNA expression in normal human tissues for LCORL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LCORL Gene



SOURCE GeneReport for Unigene cluster for LCORL Gene Hs.446201

genes like me logo Genes that share expression patterns with LCORL: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LCORL Gene

Orthologs for LCORL Gene

This gene was present in the common ancestor of animals.

Orthologs for LCORL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LCORL 35
  • 97.78 (n)
  • 97.84 (a)
LCORL 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lcorl 35
  • 95.89 (n)
  • 95.5 (a)
Lcorl 16
Lcorl 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LCORL 35
  • 99.78 (n)
  • 99.67 (a)
LCORL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lcorl 35
  • 95.02 (n)
  • 94.71 (a)
dog
(Canis familiaris)
Mammalia LCORL 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LCORL 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCORL 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LCORL 35
  • 90.26 (n)
  • 89.94 (a)
LCORL 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LCORL 36
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lcorl 35
  • 62.18 (n)
  • 57.56 (a)
wu:fc17b08 36
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Eip93F 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mbr-1 36
  • 8 (a)
OneToMany
Species with no ortholog for LCORL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LCORL Gene

ENSEMBL:
Gene Tree for LCORL (if available)
TreeFam:
Gene Tree for LCORL (if available)

Paralogs for LCORL Gene

Paralogs for LCORL Gene

(1) SIMAP similar genes for LCORL Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for LCORL Gene

genes like me logo Genes that share paralogs with LCORL: view

Variants for LCORL Gene

Structural Variations from Database of Genomic Variants (DGV) for LCORL Gene

Variant ID Type Subtype PubMed ID
nsv819053 CNV Loss 19587683
esv991821 CNV Deletion 20482838
esv2544363 CNV Deletion 19546169

Variation tolerance for LCORL Gene

Gene Damage Index Score: 3.30; 53.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCORL Gene

HapMap Linkage Disequilibrium report
LCORL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for LCORL Gene

Disorders for LCORL Gene

Relevant External Links for LCORL

Genetic Association Database (GAD)
LCORL
Human Genome Epidemiology (HuGE) Navigator
LCORL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCORL
genes like me logo Genes that share disorders with LCORL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCORL Gene

Publications for LCORL Gene

  1. Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1). (PMID: 12560079) Kunieda T. … Kubo T. (FEBS Lett. 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 67
  4. A novel common variant in DCST2 is associated with length in early life and height in adulthood. (PMID: 25281659) van der Valk R.J. … Jaddoe V.W. (Hum. Mol. Genet. 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for LCORL Gene

Sources for LCORL Gene

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