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LCOR Gene

protein-coding   GIFtS: 50
GCID: GC10P098583

Ligand Dependent Nuclear Receptor Corepressor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ligand Dependent Nuclear Receptor Corepressor1 2
MLR22 3 5
Mblk1-Related Protein 22 3
KIAA17953 5
Ligand-Dependent Corepressor2
LCoR3

External Ids:    HGNC: 295031   Entrez Gene: 844582   Ensembl: ENSG000001962337   OMIM: 6076985   UniProtKB: Q96JN03   

Export aliases for LCOR gene to outside databases

Previous GC identifer: GC10P092221


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LCOR Gene:
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to
agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box
(Fernandes et al., 2003 (PubMed 12535528)).(supplied by OMIM, Mar 2008)

GeneCards Summary for LCOR Gene:
LCOR (ligand dependent nuclear receptor corepressor) is a protein-coding gene. Diseases associated with LCOR include portal hypertension, and hypertension. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is LCORL.

UniProtKB/Swiss-Prot: LCOR_HUMAN, Q96JN0
Function: May act as transcription activator that binds DNA elements with the sequence
5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target
nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB,
RARG, RXRA and VDR

Gene Wiki entry for LCOR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LCOR gene promoter:
         AML1a   RREB-1   HNF-3beta   YY1   GATA-2   Meis-1b   Nkx6-1   HFH-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLCOR promoter sequence
   Search Chromatin IP Primers for LCOR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LCOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q24

LCOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LCOR gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P098583:  view genomic region     (about GC identifiers)

Start:
98,592,017 bp from pter      End:
98,740,800 bp from pter
Size:
148,784 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LCOR_HUMAN, Q96JN0 (See protein sequence)
Recommended Name: Ligand-dependent corepressor  
Size: 433 amino acids; 47007 Da
Subunit: Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6.
Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2
Sequence caution: Sequence=BAB47424.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for LCOR:
2COB (3D)    
Secondary accessions: D3DR47 Q5VW16 Q7Z723 Q86T32 Q86T33 Q8N3L6
Alternative splicing: 2 isoforms:  Q96JN0-1   Q96JN0-2   

Explore the universe of human proteins at neXtProt for LCOR: NX_Q96JN0

Explore proteomics data for LCOR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LCOR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001164236.1  NP_001164237.1  NP_115816.2  

    ENSEMBL proteins: 
     ENSP00000360144   ENSP00000348298   ENSP00000360138   ENSP00000443431  

    LCOR Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for LCOR
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    Novus Biologicals LCOR Proteins
    Novus Biologicals LCOR Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for LCOR

    LCOR Antibody Products:

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    Cloud-Clone Corp. ELISAs for LCOR
    Cloud-Clone Corp. CLIAs for LCOR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009057 Homeodomain-like
     IPR007889 HTH_Psq

    Graphical View of Domain Structure for InterPro Entry Q96JN0

    ProtoNet protein and cluster: Q96JN0

    UniProtKB/Swiss-Prot: LCOR_HUMAN, Q96JN0
    Similarity: Contains 1 HTH psq-type DNA-binding domain


    LCOR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LCOR_HUMAN, Q96JN0
    Function: May act as transcription activator that binds DNA elements with the sequence
    5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target
    nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB,
    RARG, RXRA and VDR

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008134transcription factor binding IEA--
         
    LCOR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LCOR:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LCOR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LCOR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LCOR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LCOR

    miRNA
    Products:
        
    miRTarBase miRNAs that target LCOR:
    hsa-mir-103a-3p (MIRT027215), hsa-mir-17-5p (MIRT050889), hsa-mir-425-5p (MIRT016678), hsa-mir-877-3p (MIRT037058), hsa-mir-27b-3p (MIRT046212), hsa-mir-193b-3p (MIRT041427), hsa-mir-615-3p (MIRT007027), hsa-mir-335-5p (MIRT018627), hsa-mir-101-3p (MIRT027388)

    Block miRNA regulation of human, mouse, rat LCOR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LCOR (see all 252):
    hsa-miR-140-5p hsa-miR-3938 hsa-miR-520f hsa-miR-146a hsa-miR-106a hsa-miR-199a-3p hsa-miR-128 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidLCOR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LCOR
    Predesigned siRNA for gene silencing in human, mouse, rat LCOR

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for LCOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for LCOR
    Sino Biological Human cDNA Clone for LCOR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LCOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCOR

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LCOR
    Browse ESI BIO Cell Lines and PureStem Progenitors for LCOR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCOR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LCOR_HUMAN, Q96JN0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    LCOR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LCOR
    Interactions:

        GeneGlobe Interaction Network for LCOR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for LCOR (Q96JN03 ENSP000003482984) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTBP2P565453, ENSP000003118254I2D: score=1 STRING: ENSP00000311825
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    HDAC6Q9UBN73, ENSP000003340614I2D: score=1 STRING: ENSP00000334061
    CTBP1Q133633, ENSP000002909214I2D: score=1 STRING: ENSP00000290921
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IEA--

    LCOR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LCOR



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LCOR gene (3 alternative transcripts): 
    NM_001170765.1  NM_001170766.1  NM_032440.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371103 ENST00000356016 ENST00000371097(uc001kms.2 uc001kmu.2)
    ENST00000493486 ENST00000469510 ENST00000498444 ENST00000463415 ENST00000540664(uc001kmr.3 uc009xvg.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LCOR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LCOR (see all 252):
    hsa-miR-140-5p hsa-miR-3938 hsa-miR-520f hsa-miR-146a hsa-miR-106a hsa-miR-199a-3p hsa-miR-128 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidLCOR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LCOR
    Predesigned siRNA for gene silencing in human, mouse, rat LCOR
    Clone
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    OriGene clones in human, mouse for LCOR (see all 14)
    OriGene ORF clones in mouse, rat for LCOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for LCOR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LCOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCOR
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LCOR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LCOR
      QuantiTect SYBR Green Assays in human, mouse, rat LCOR
      QuantiFast Probe-based Assays in human, mouse, rat LCOR

    Selected AceView cDNA sequences (see all 51):

    CK905040 AI023992 AA342019 AA429975 BM829125 CA391494 CF528377 CA391495 
    AK095345 AK023248 AW468300 AW663968 BC053359 BF095722 AB058698 AA806691 
    AI799125 BF432503 AI826032 AL832044 AW418690 BU153548 AI393626 AL832106 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LCOR (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12
    SP1:              -     -     -     -           -     -                                                           -         
    SP2:                                            -     -                                                                     
    SP3:                                -           -     -                                                                     
    SP4:              -     -     -     -           -     -                                                                     
    SP5:              -     -     -     -           -     -     -     -                                                         


    ECgene alternative splicing isoforms for LCOR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LCOR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTTTGGA
    LCOR Expression
    About this image

    LCOR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LCOR Protein Expression

    UniProtKB/Swiss-Prot: LCOR_HUMAN, Q96JN0
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCOR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LCOR gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lcor1 , 5 ligand dependent nuclear receptor corepressor1, 5 96.84(n)1
    97.92(a)1
      19 (34.94 cM)5
    2123911  NM_172154.41  NP_742166.11 
     415496395 
    chicken
    (Gallus gallus)
    Aves LCOR1 ligand dependent nuclear receptor corepressor 91.84(n)
    93.76(a)
      423847  XM_421716.4  XP_421716.4 
    lizard
    (Anolis carolinensis)
    Reptilia LCOR6
    ligand dependent nuclear receptor corepressor
    90(a)
    1 ↔ 1
    GL343239.1(1982928-1986735)
    zebrafish
    (Danio rerio)
    Actinopterygii lcor1 ligand dependent nuclear receptor corepressor 64.54(n)
    64.13(a)
      558560  NM_001079972.1  NP_001073441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eip93F6
    Ecdysone-induced protein 93F
    2(a)
    1 → many
    3R(17774836-17837910)
    worm
    (Caenorhabditis elegans)
    Secernentea mbr-16
    Protein MBR-1 (mbr-1) mRNA, complete cds
    8(a)
    1 → many
    X(10719550-10722054) WBGene00011315


    ENSEMBL Gene Tree for LCOR (if available)
    TreeFam Gene Tree for LCOR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LCOR gene
    LCORL2  
    1 SIMAP similar gene for LCOR using alignment to 2 protein entries:     LCOR_HUMAN (see all proteins):
    LCORL

    LCOR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LCOR (see all 2533)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1173815971,2
    C,F--98595212(+) GGGGCC/TTCATA 3 -- int11Minor allele frequency- T:0.02NA 120
    rs1470463881,2
    --98595222(+) ATTTTC/TTCTTT 3 -- int10--------
    rs1476658981,2
    C--98595252(+) TTTTAA/GGAGGA 3 -- int10--------
    rs78952141,2
    C,F,A,H--98595326(+) CCTTAG/TGCAAT 3 -- int119Minor allele frequency- T:0.36NS EA NA CSA WA 2321
    rs1424346711,2
    --98595410(+) GTTTCA/TCTTGA 3 -- int10--------
    rs1883431211,2
    --98595469(+) ATTTAC/TAGCAG 3 -- int10--------
    rs1464690821,2
    --98595523(+) CTTCTA/GTTAGT 3 -- int10--------
    rs1385972041,2
    --98595581(+) TTAAAG/TGATTA 3 -- int10--------
    rs1915827021,2
    --98595733(+) CTGCGC/TCTGAT 3 -- int10--------
    rs1844492351,2
    --98595850(+) TAAAAA/GTAGGA 3 -- int10--------

    HapMap Linkage Disequilibrium report for LCOR (98592017 - 98740800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LCOR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2588205CNV Deletion19546169
    esv2401890CNV Deletion18987734
    nsv527351CNV Loss19592680
    nsv831951CNV Gain17160897
    nsv825532CNV Gain20364138
    nsv895910CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LCOR
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607698    OMIM disorders: --

    6 diseases for LCOR:    
    About MalaCards
    portal hypertension    hypertension    prostate cancer    prostatitis
    multiple myeloma    myeloma


    LCOR for disorders           About GeneDecksing

    Genetic Association Database (GAD): LCOR
    Human Genome Epidemiology (HuGE) Navigator: LCOR (2 documents)

    Export disorders for LCOR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LCOR gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with LCOR)
        Utopia: connect your pdf to the dynamic
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    1. Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. (PubMed id 12535528)1, 2, 3 Fernandes I.... White J.H. (Mol. Cell 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Corepressor recruitment by agonist-bound nuclear receptors. (PubMed id 15193453)1, 3 White J.H....Yang X.J. (Vitam. Horm. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. Coordinated histone modifications mediated by a CtBP co-repressor complex. (PubMed id 12700765)1, 2 Shi Y.... Shi Y. (Nature 2003)
    7. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    8. The CCND1 c.870G&gt;A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. (PubMed id 23502783)1 Weinhold N....Hemminki K. (Nat. Genet. 2013)
    9. Ligand-dependent corepressor (LCoR) recruitment by Kruppel-like factor 6 (KLF6) regulates expression of the cyclin-dependent kinase inhibitor CDKN1A gene. (PubMed id 22277651)1 Calderon M.R....White J.H. (J. Biol. Chem. 2012)
    10. miR-615-3p promotes the phagocytic capacity of splenic macrophages by targeting ligand-dependent nuclear receptor corepressor in cirrhosis-related portal hypertension. (PubMed id 21565892)1 Jiang A....Yang J. (Exp. Biol. Med. (Maywood) 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84458 HGNC: 29503 AceView: MLR2 Ensembl:ENSG00000196233 euGenes: HUgn84458
    ECgene: LCOR H-InvDB: LCOR

    (According to HUGE)
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    HUGE: KIAA1795

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LCOR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LCOR gene:
    Search GeneIP for patents involving LCOR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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