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Aliases for LCN9 Gene

Aliases for LCN9 Gene

  • Lipocalin 9 2 3
  • MUP-Like Lipocalin 2 3 4
  • Epididymal-Specific Lipocalin-9 2
  • Epididymis Luminal Protein 129 3
  • 9230102I19Rik 3
  • HEL129 3

External Ids for LCN9 Gene

Previous GeneCards Identifiers for LCN9 Gene

  • GC09P133995
  • GC09P135781
  • GC09P137694
  • GC09P138555
  • GC09P108017

Summaries for LCN9 Gene

Entrez Gene Summary for LCN9 Gene

  • Members of the lipocalin family, such as LCN9, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]

GeneCards Summary for LCN9 Gene

LCN9 (Lipocalin 9) is a Protein Coding gene. Diseases associated with LCN9 include tick infestation and parasitic ectoparasitic infectious disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include transporter activity and pheromone binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCN9 Gene

Genomics for LCN9 Gene

Regulatory Elements for LCN9 Gene

Genomic Location for LCN9 Gene

Chromosome:
9
Start:
135,663,322 bp from pter
End:
135,666,769 bp from pter
Size:
3,448 bases
Orientation:
Plus strand

Genomic View for LCN9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LCN9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCN9 Gene

Proteins for LCN9 Gene

  • Protein details for LCN9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WX39-LCN9_HUMAN
    Recommended name:
    Epididymal-specific lipocalin-9
    Protein Accession:
    Q8WX39
    Secondary Accessions:
    • C9J5F0
    • Q6JVE7

    Protein attributes for LCN9 Gene

    Size:
    176 amino acids
    Molecular mass:
    20285 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD13244.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for LCN9 Gene

Proteomics data for LCN9 Gene at MOPED

Post-translational modifications for LCN9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCN9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCN9 Gene

Domains & Families for LCN9 Gene

Gene Families for LCN9 Gene

Suggested Antigen Peptide Sequences for LCN9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WX39

UniProtKB/Swiss-Prot:

LCN9_HUMAN :
  • Belongs to the calycin superfamily. Lipocalin family.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with LCN9: view

Function for LCN9 Gene

Gene Ontology (GO) - Molecular Function for LCN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005550 pheromone binding IEA --
genes like me logo Genes that share ontologies with LCN9: view

Phenotypes for LCN9 Gene

genes like me logo Genes that share phenotypes with LCN9: view

Animal Model Products

miRNA for LCN9 Gene

miRTarBase miRNAs that target LCN9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LCN9

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LCN9 Gene

Localization for LCN9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCN9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCN9 Gene COMPARTMENTS Subcellular localization image for LCN9 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for LCN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LCN9: view

Pathways & Interactions for LCN9 Gene

genes like me logo Genes that share pathways with LCN9: view

Interacting Proteins for LCN9 Gene

Gene Ontology (GO) - Biological Process for LCN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with LCN9: view

No data available for SIGNOR curated interactions for LCN9 Gene

Drugs & Compounds for LCN9 Gene

(5) Drugs for LCN9 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(Sec-Butyl)Thiazole Experimental Pharma Target 0
2-Isobutyl-3-Methoxypyrazine Experimental Pharma Target 0
2-Isopropyl-3-methoxypyrazine Experimental Pharma Target 0
6-Hydroxy-6-Methyl-Heptan-3-One Experimental Pharma Target 0
D-Limonene 1,2-Epoxide Experimental Pharma Target 0
genes like me logo Genes that share compounds with LCN9: view

Transcripts for LCN9 Gene

mRNA/cDNA for LCN9 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCN9 Gene

Lipocalin 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LCN9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCN9 Gene

No ASD Table

Relevant External Links for LCN9 Gene

GeneLoc Exon Structure for
LCN9
ECgene alternative splicing isoforms for
LCN9

Expression for LCN9 Gene

mRNA expression in normal human tissues for LCN9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCN9 Gene

This gene is overexpressed in Brain - Substantia nigra (x5.1), Pituitary (x5.0), Brain - Putamen (basal ganglia) (x4.7), and Brain - Amygdala (x4.5).

Protein differential expression in normal tissues from HIPED for LCN9 Gene

This gene is overexpressed in Testis (41.1) and Ovary (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LCN9 Gene



SOURCE GeneReport for Unigene cluster for LCN9 Gene Hs.532679

genes like me logo Genes that share expression patterns with LCN9: view

Protein tissue co-expression partners for LCN9 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LCN9 Gene

Orthologs for LCN9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LCN9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LCN9 35
  • 69.11 (n)
  • 51.22 (a)
LCN9 36
  • 44 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LCN9 35
  • 74.2 (n)
  • 62.33 (a)
LCN9 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lcn9 35
  • 73.11 (n)
  • 58.67 (a)
Lcn9 16
Lcn9 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LCN9 35
  • 97.26 (n)
  • 95.21 (a)
LCN9 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lcn9 35
  • 71.56 (n)
  • 58 (a)
oppossum
(Monodelphis domestica)
Mammalia LCN9 36
  • 26 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCN9 36
  • 18 (a)
OneToOne
Species with no ortholog for LCN9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCN9 Gene

ENSEMBL:
Gene Tree for LCN9 (if available)
TreeFam:
Gene Tree for LCN9 (if available)

Paralogs for LCN9 Gene

No data available for Paralogs for LCN9 Gene

Variants for LCN9 Gene

Sequence variations from dbSNP and Humsavar for LCN9 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs86932 -- 135,667,116(+) AGGAA(G/T)TCAGC downstream-variant-500B
rs484198 -- 135,666,395(+) GATTT(A/C)GGGCC downstream-variant-500B, utr-variant-3-prime
rs488539 -- 135,662,088(-) agaga(A/C)agcgc upstream-variant-2KB
rs492708 -- 135,665,410(-) GGGCC(A/G)GACTT intron-variant
rs505017 -- 135,662,668(-) tataa(C/T)taagg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LCN9 Gene

Variant ID Type Subtype PubMed ID
nsv466659 CNV Loss 19166990
nsv6760 CNV Insertion 18451855
nsv894256 CNV Loss 21882294
nsv831756 CNV Loss 17160897
nsv818735 CNV Gain 17921354
nsv517335 CNV Loss 19592680
dgv8368n71 CNV Loss 21882294
esv2739304 CNV Deletion 23290073
esv2739305 CNV Deletion 23290073

Variation tolerance for LCN9 Gene

Residual Variation Intolerance Score: 88.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCN9 Gene

HapMap Linkage Disequilibrium report
LCN9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCN9 Gene

Disorders for LCN9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LCN9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tick infestation
  • tick infestations
parasitic ectoparasitic infectious disease
  • ectoparasitism
- elite association
Search LCN9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LCN9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCN9
genes like me logo Genes that share disorders with LCN9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LCN9 Gene

Publications for LCN9 Gene

  1. Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2. (PMID: 15363845) Suzuki K. … Orgebin-Crist M.-C. (Gene 2004) 2 23 67
  2. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 67
  5. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25

Products for LCN9 Gene

Sources for LCN9 Gene

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