Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LCN2 Gene

Aliases for LCN2 Gene

  • Lipocalin 2 2 3
  • Oncogene 24p3 2 3 4
  • NGAL 3 4 6
  • 25 KDa Alpha-2-Microglobulin-Related Subunit Of MMP-9 3 4
  • Neutrophil Gelatinase-Associated Lipocalin 2 3
  • Siderocalin LCN2 3 4
  • Lipocalin-2 3 4
  • P25 3 4
  • Migration-Stimulating Factor Inhibitor 3
  • Lipocalin 2 (Oncogene 24p3) 2
  • Siderocalin 2
  • 24p3 3
  • MSFI 3
  • HNL 4

External Ids for LCN2 Gene

Previous GeneCards Identifiers for LCN2 Gene

  • GC09P122026
  • GC09P122558
  • GC09P124365
  • GC09P126287
  • GC09P127991
  • GC09P129951
  • GC09P130911
  • GC09P100525

Summaries for LCN2 Gene

GeneCards Summary for LCN2 Gene

LCN2 (Lipocalin 2) is a Protein Coding gene. Diseases associated with LCN2 include klebsiella infection and renovascular hypertension. Among its related pathways are Alzheimers Disease Pathway. GO annotations related to this gene include protein homodimerization activity and iron ion binding. An important paralog of this gene is LCN12.

UniProtKB/Swiss-Prot for LCN2 Gene

  • Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Gene Wiki entry for LCN2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCN2 Gene

Genomics for LCN2 Gene

Regulatory Elements for LCN2 Gene

Genomic Location for LCN2 Gene

Start:
128,149,071 bp from pter
End:
128,153,455 bp from pter
Size:
4,385 bases
Orientation:
Plus strand

Genomic View for LCN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCN2 Gene

Proteins for LCN2 Gene

  • Protein details for LCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80188-NGAL_HUMAN
    Recommended name:
    Neutrophil gelatinase-associated lipocalin
    Protein Accession:
    P80188
    Secondary Accessions:
    • A6NII8
    • B4DWV4
    • B7ZAA2
    • P30150
    • Q5SYV9
    • Q5SYW0
    • Q6FGL5
    • Q92683

    Protein attributes for LCN2 Gene

    Size:
    198 amino acids
    Molecular mass:
    22588 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9.
    SequenceCaution:
    • Sequence=CAI13824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LCN2 Gene

    Alternative splice isoforms for LCN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCN2 Gene

Proteomics data for LCN2 Gene at MOPED

Post-translational modifications for LCN2 Gene

  • Glycosylation at Asn85
  • Modification sites at PhosphoSitePlus

Other Protein References for LCN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCN2 Gene

Domains for LCN2 Gene

Gene Families for LCN2 Gene

HGNC:
  • LCN :Lipocalins

Suggested Antigen Peptide Sequences for LCN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80188

UniProtKB/Swiss-Prot:

NGAL_HUMAN :
  • P80188
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with LCN2: view

Function for LCN2 Gene

Molecular function for LCN2 Gene

GENATLAS Biochemistry: neutrophil gelatinase-associated lipocalin 2,25kDa,found at moderate levels,only in breast and lung,component of human tear (lipophilic ligand carrier protein superfamily,lipocalin family,Kernel group),modulator of inflammation,involved in the transport of hydrophobic ligands
UniProtKB/Swiss-Prot Function: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
UniProtKB/Swiss-Prot Induction: Expression is activated by the oncoprotein BCR-ABL; BCR-ABL misregulates expression via the JAK/STAT pathway and binding of STAT5A to the promoter.

Gene Ontology (GO) - Molecular Function for LCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding --
GO:0005215 transporter activity IEA --
GO:0005506 iron ion binding ISS --
GO:0005515 protein binding --
GO:0036094 small molecule binding IEA --
genes like me logo Genes that share ontologies with LCN2: view
genes like me logo Genes that share phenotypes with LCN2: view

Animal Models for LCN2 Gene

MGI Knock Outs for LCN2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LCN2 Gene

Localization for LCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCN2 Gene

Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCN2 Gene COMPARTMENTS Subcellular localization image for LCN2 gene
Compartment Confidence
extracellular 5
cytosol 4
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005829 cytosol --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LCN2: view

Pathways for LCN2 Gene

SuperPathways for LCN2 Gene

Superpath Contained pathways
1 Alzheimers Disease Pathway
genes like me logo Genes that share pathways with LCN2: view

Pathways by source for LCN2 Gene

1 Qiagen pathway for LCN2 Gene

Gene Ontology (GO) - Biological Process for LCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport IEA --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0006915 apoptotic process IEA --
GO:0006979 response to oxidative stress --
genes like me logo Genes that share ontologies with LCN2: view

Compounds for LCN2 Gene

(7) Drugbank Compounds for LCN2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2,3,-Dihydroxybenzoylserine
127658-43-9 target
2,3-Dihydroxy-Benzoic Acid
303-38-8 target
Alpha-D-Mannose
3458-28-4 target
Carboxymycobactin S
target
Carboxymycobactin T
target

(26) Novoseek inferred chemical compound relationships for LCN2 Gene

Compound -log(P) Hits PubMed IDs
enterobactin 72.4 4
creatinine 67.7 90
iron 42.7 37
turpentine 30 1
tripeptide s 20.8 3
genes like me logo Genes that share compounds with LCN2: view

Transcripts for LCN2 Gene

Unigene Clusters for LCN2 Gene

Lipocalin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LCN2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - - - - - - -
SP5:
SP6: -
SP7: - -

Relevant External Links for LCN2 Gene

GeneLoc Exon Structure for
LCN2
ECgene alternative splicing isoforms for
LCN2

Expression for LCN2 Gene

mRNA expression in normal human tissues for LCN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCN2 Gene

This gene is overexpressed in Whole Blood (12.3), Minor Salivary Gland (10.8), Esophagus - Mucosa (7.7), Vagina (4.7), and Stomach (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LCN2 Gene

SOURCE GeneReport for Unigene cluster for LCN2 Gene Hs.204238

mRNA Expression by UniProt/SwissProt for LCN2 Gene

P80188-NGAL_HUMAN
Tissue specificity: Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.
genes like me logo Genes that share expressions with LCN2: view

Orthologs for LCN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LCN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCN2 35
  • 99.33 (n)
  • 98.99 (a)
LCN2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LCN2 35
  • 77.33 (n)
  • 69.54 (a)
LCN2 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LCN2 35
  • 77.72 (n)
  • 66.3 (a)
LCN2 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lcn2 35
  • 72.25 (n)
  • 63.13 (a)
Lcn2 16
Lcn2 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LCN2 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lcn2 35
  • 71.32 (n)
  • 64.25 (a)
Species with no ortholog for LCN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCN2 Gene

ENSEMBL:
Gene Tree for LCN2 (if available)
TreeFam:
Gene Tree for LCN2 (if available)

Paralogs for LCN2 Gene

Paralogs for LCN2 Gene

Selected SIMAP similar genes for LCN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LCN2: view

Variants for LCN2 Gene

Sequence variations from dbSNP and Humsavar for LCN2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs11927 -- 128,151,997(+) CAAAA(C/T)AGGGA reference, synonymous-codon
rs12260 -- 128,153,336(-) TGTTC(A/G)GGCTG utr-variant-3-prime
rs1061879 -- 128,153,245(+) TTATT(C/T)TGCTG intron-variant
rs2232623 -- 128,149,752(+) GAGCG(C/T)TGGGC intron-variant
rs2232624 -- 128,150,060(+) CTTCT(A/G)GACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LCN2 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893891 CNV Loss 21882294
dgv8294n71 CNV Loss 21882294
nsv893894 CNV Gain 21882294

Relevant External Links for LCN2 Gene

HapMap Linkage Disequilibrium report
LCN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCN2 Gene

Disorders for LCN2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for LCN2 Gene including...

Search for LCN2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for LCN2 Gene

(47) Novoseek inferred disease relationships for LCN2 Gene

Disease -log(P) Hits PubMed IDs
renal disease 59.6 40
renal failure acute 49.3 5
inflammation 45.5 35
proteinuria 38.1 8
response acute phase 29.3 2

Relevant External Links for LCN2

Genetic Association Database (GAD)
LCN2
Human Genome Epidemiology (HuGE) Navigator
LCN2
genes like me logo Genes that share disorders with LCN2: view

No data available for UniProtKB/Swiss-Prot for LCN2 Gene

Publications for LCN2 Gene

  1. Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils. (PMID: 8060329) Bundgaard J.R. … Kjeldsen L. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  2. Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin. (PMID: 10684642) Goetz D.H. … Strong R.K. (Biochemistry 2000) 3 4 23
  3. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. (PMID: 7683678) Kjeldsen L. … Borregaard N. (J. Biol. Chem. 1993) 2 3 4
  4. Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells. (PMID: 7835423) Bartsch S. … Tschesche H. (FEBS Lett. 1995) 3 4
  5. Neutrophil gelatinase-associated lipocalin and hepcidin: what do they have in common and is there a potential interaction? (PMID: 20502037) Malyszko J. … Macdougall I.C. (Kidney Blood Press. Res. 2010) 3 23

Products for LCN2 Gene

  • Addgene plasmids for LCN2

Sources for LCN2 Gene

Back to Top

Content