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Aliases for LCN2 Gene

Aliases for LCN2 Gene

  • Lipocalin 2 2 3 5
  • Oncogene 24p3 2 3 4
  • 25 KDa Alpha-2-Microglobulin-Related Subunit Of MMP-9 3 4
  • Siderocalin LCN2 3 4
  • Lipocalin-2 3 4
  • NGAL 3 4
  • P25 3 4
  • Neutrophil Gelatinase-Associated Lipocalin 2
  • Migration-Stimulating Factor Inhibitor 3
  • Lipocalin 2 (Oncogene 24p3) 2
  • Siderocalin 2
  • 24p3 3
  • MSFI 3
  • HNL 4

External Ids for LCN2 Gene

Previous GeneCards Identifiers for LCN2 Gene

  • GC09P122026
  • GC09P122558
  • GC09P124365
  • GC09P126287
  • GC09P127991
  • GC09P129951
  • GC09P130911
  • GC09P100525

Summaries for LCN2 Gene

Entrez Gene Summary for LCN2 Gene

  • This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]

GeneCards Summary for LCN2 Gene

LCN2 (Lipocalin 2) is a Protein Coding gene. Diseases associated with LCN2 include klebsiella infection and kidney disease. Among its related pathways are Alzheimers Disease Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein homodimerization activity and iron ion binding. An important paralog of this gene is LCN12.

UniProtKB/Swiss-Prot for LCN2 Gene

  • Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Gene Wiki entry for LCN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCN2 Gene

Genomics for LCN2 Gene

Regulatory Elements for LCN2 Gene

Genomic Location for LCN2 Gene

Chromosome:
9
Start:
128,149,071 bp from pter
End:
128,153,455 bp from pter
Size:
4,385 bases
Orientation:
Plus strand

Genomic View for LCN2 Gene

Genes around LCN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCN2 Gene

Proteins for LCN2 Gene

  • Protein details for LCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80188-NGAL_HUMAN
    Recommended name:
    Neutrophil gelatinase-associated lipocalin
    Protein Accession:
    P80188
    Secondary Accessions:
    • A6NII8
    • B4DWV4
    • B7ZAA2
    • P30150
    • Q5SYV9
    • Q5SYW0
    • Q6FGL5
    • Q92683

    Protein attributes for LCN2 Gene

    Size:
    198 amino acids
    Molecular mass:
    22588 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9.
    SequenceCaution:
    • Sequence=CAI13824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LCN2 Gene

    Alternative splice isoforms for LCN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCN2 Gene

Proteomics data for LCN2 Gene at MOPED

Post-translational modifications for LCN2 Gene

  • Glycosylation at Asn 85
  • Modification sites at PhosphoSitePlus

Other Protein References for LCN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LCN2 (Lipocalin-2/NGAL)

No data available for DME Specific Peptides for LCN2 Gene

Domains & Families for LCN2 Gene

Gene Families for LCN2 Gene

Suggested Antigen Peptide Sequences for LCN2 Gene

Graphical View of Domain Structure for InterPro Entry

P80188

UniProtKB/Swiss-Prot:

NGAL_HUMAN :
  • Belongs to the calycin superfamily. Lipocalin family.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with LCN2: view

Function for LCN2 Gene

Molecular function for LCN2 Gene

GENATLAS Biochemistry:
neutrophil gelatinase-associated lipocalin 2,25kDa,found at moderate levels,only in breast and lung,component of human tear (lipophilic ligand carrier protein superfamily,lipocalin family,Kernel group),modulator of inflammation,involved in the transport of hydrophobic ligands
UniProtKB/Swiss-Prot Function:
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
UniProtKB/Swiss-Prot Induction:
Expression is activated by the oncoprotein BCR-ABL; BCR-ABL misregulates expression via the JAK/STAT pathway and binding of STAT5A to the promoter.
genes like me logo Genes that share phenotypes with LCN2: view

Animal Models for LCN2 Gene

MGI Knock Outs for LCN2:

Animal Model Products

miRNA for LCN2 Gene

miRTarBase miRNAs that target LCN2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LCN2 Gene

Localization for LCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCN2 Gene

Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCN2 Gene COMPARTMENTS Subcellular localization image for LCN2 gene
Compartment Confidence
extracellular 5
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for LCN2 Gene

Pathways & Interactions for LCN2 Gene

genes like me logo Genes that share pathways with LCN2: view

Pathways by source for LCN2 Gene

1 Qiagen pathway for LCN2 Gene

Gene Ontology (GO) - Biological Process for LCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with LCN2: view

No data available for SIGNOR curated interactions for LCN2 Gene

Drugs & Compounds for LCN2 Gene

(22) Drugs for LCN2 Gene - From: Novoseek, DrugBank, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved Nutra 413
2,3,-Dihydroxybenzoylserine Experimental Pharma Target 0
2-Pyrocatechuic acid Experimental Pharma Target 0
Carboxymycobactin S Experimental Pharma Target 0
Carboxymycobactin T Experimental Pharma Target 0

(13) Additional Compounds for LCN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LCN2: view

Transcripts for LCN2 Gene

Unigene Clusters for LCN2 Gene

Lipocalin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCN2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - - - - - - -
SP5:
SP6: -
SP7: - -

Relevant External Links for LCN2 Gene

GeneLoc Exon Structure for
LCN2
ECgene alternative splicing isoforms for
LCN2

Expression for LCN2 Gene

mRNA expression in normal human tissues for LCN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCN2 Gene

This gene is overexpressed in Whole Blood (x12.3), Minor Salivary Gland (x10.8), Esophagus - Mucosa (x7.7), Vagina (x4.7), and Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for LCN2 Gene

This gene is overexpressed in Neutrophil (31.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LCN2 Gene



SOURCE GeneReport for Unigene cluster for LCN2 Gene Hs.204238

mRNA Expression by UniProt/SwissProt for LCN2 Gene

P80188-NGAL_HUMAN
Tissue specificity: Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with LCN2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for LCN2 Gene

Orthologs for LCN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LCN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCN2 35
  • 99.33 (n)
  • 98.99 (a)
LCN2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LCN2 36
  • 69 (a)
OneToOne
LCN2 35
  • 77.33 (n)
  • 69.54 (a)
dog
(Canis familiaris)
Mammalia LCN2 35
  • 77.72 (n)
  • 66.3 (a)
LCN2 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lcn2 16
Lcn2 36
  • 62 (a)
OneToOne
Lcn2 35
  • 72.25 (n)
  • 63.13 (a)
oppossum
(Monodelphis domestica)
Mammalia LCN2 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lcn2 35
  • 71.32 (n)
  • 64.25 (a)
Species with no ortholog for LCN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCN2 Gene

ENSEMBL:
Gene Tree for LCN2 (if available)
TreeFam:
Gene Tree for LCN2 (if available)

Paralogs for LCN2 Gene

Paralogs for LCN2 Gene

(2) SIMAP similar genes for LCN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LCN2: view

Variants for LCN2 Gene

Sequence variations from dbSNP and Humsavar for LCN2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1061879 -- 128,153,245(+) TTATT(C/T)TGCTG intron-variant
rs2232627 -- 128,151,911(+) GTTAC(C/T)CTGGA reference, missense
rs2232628 -- 128,152,074(+) CTTAG(C/T)GGGAG intron-variant
rs2232629 -- 128,152,155(+) CTGCC(A/G)GCCAC intron-variant
rs2232630 -- 128,152,347(+) TCCCT(A/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LCN2 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893891 CNV Loss 21882294
dgv8294n71 CNV Loss 21882294
nsv893894 CNV Gain 21882294

Variation tolerance for LCN2 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCN2 Gene

HapMap Linkage Disequilibrium report
LCN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCN2 Gene

Disorders for LCN2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for LCN2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
klebsiella infection
  • klebsiella
kidney disease
  • nephropathy
deficiency anemia
  • anemia
focal segmental glomerulosclerosis
  • opitz-kaveggia syndrome
congenital heart disease
  • congestive heart failure
- elite association - COSMIC cancer census association via MalaCards
Search LCN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LCN2

Genetic Association Database (GAD)
LCN2
Human Genome Epidemiology (HuGE) Navigator
LCN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCN2
genes like me logo Genes that share disorders with LCN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LCN2 Gene

Publications for LCN2 Gene

  1. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. (PMID: 7683678) Kjeldsen L. … Borregaard N. (J. Biol. Chem. 1993) 2 3 4 67
  2. Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. (PMID: 19540040) Bolignano D. … Buemi M. (Cancer Lett. 2010) 3 23
  3. Neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery: the effect of baseline renal function on diagnostic performance. (PMID: 20056755) McIlroy D.R. … Lee H.T. (Clin J Am Soc Nephrol 2010) 3 23
  4. Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition. (PMID: 20086155) Miethke M. … Skerra A. (Antimicrob. Agents Chemother. 2010) 3 23
  5. Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure. (PMID: 20123318) Aghel A. … Tang W.H. (J. Card. Fail. 2010) 3 23

Products for LCN2 Gene

Sources for LCN2 Gene

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