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Aliases for LCN15 Gene

Aliases for LCN15 Gene

  • Lipocalin 15 2 3 5
  • Lipocalin-15 3
  • MSFL2541 3
  • PRO6093 3
  • UNQ2541 3

External Ids for LCN15 Gene

Previous GeneCards Identifiers for LCN15 Gene

  • GC09M138775
  • GC09M139654
  • GC09M109113

Summaries for LCN15 Gene

GeneCards Summary for LCN15 Gene

LCN15 (Lipocalin 15) is a Protein Coding gene. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and small molecule binding. An important paralog of this gene is ENSG00000284341.

Additional gene information for LCN15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCN15 Gene

Genomics for LCN15 Gene

Regulatory Elements for LCN15 Gene

Enhancers for LCN15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H136765 1.2 Ensembl ENCODE 16.3 +3.5 3549 1 HDGF PKNOX1 ATF1 ARID4B ZNF2 ZNF143 ZNF207 FOS ATF7 SP3 LCN8 LCN15
GH09H136760 1.1 Ensembl ENCODE 14.8 +9.0 9039 0 HDAC1 ZNF2 RAD21 GLIS2 EGR1 ZNF366 ZNF143 ZNF548 CREM DEK EHMT1 LCN15 SDCCAG3 SNHG7 ANAPC2 LCN8
GH09H136762 1 Ensembl ENCODE 15.3 +6.7 6701 1 TBP CTCF DRAP1 KLF1 SAP130 ARID4B ZNF384 ZIC2 GLIS2 POLR2A LCN15 LCN8
GH09H137233 1.8 FANTOM5 ENCODE dbSUPER 8.3 -468.2 -468192 9 MLX FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZC3H11A ZFP41 EHMT1 SDCCAG3 NDOR1 ANAPC2 LOC651337 INPP5E DPH7 MAN1B1 SEC16A IL9RP1
GH09H136757 1.1 Ensembl ENCODE 13 +12.0 11958 1 PKNOX1 PTBP1 RB1 ARID4B ZNF2 RAD21 GLIS2 ZNF143 KLF7 RCOR1 LCN8 EHMT1 SDCCAG3 LCN15 ANAPC2 SEC16A SNHG7 DPH7 MAN1B1 LCN6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LCN15 on UCSC Golden Path with GeneCards custom track

Genomic Location for LCN15 Gene

Chromosome:
9
Start:
136,759,634 bp from pter
End:
136,770,114 bp from pter
Size:
10,481 bases
Orientation:
Minus strand

Genomic View for LCN15 Gene

Genes around LCN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCN15 Gene

Proteins for LCN15 Gene

  • Protein details for LCN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWW0-LCN15_HUMAN
    Recommended name:
    Lipocalin-15
    Protein Accession:
    Q6UWW0

    Protein attributes for LCN15 Gene

    Size:
    184 amino acids
    Molecular mass:
    20454 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LCN15 Gene

neXtProt entry for LCN15 Gene

Post-translational modifications for LCN15 Gene

No Post-translational modifications

Other Protein References for LCN15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCN15 Gene

Domains & Families for LCN15 Gene

Gene Families for LCN15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LCN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWW0

UniProtKB/Swiss-Prot:

LCN15_HUMAN :
  • Belongs to the calycin superfamily. Lipocalin family.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with LCN15: view

Function for LCN15 Gene

Gene Ontology (GO) - Molecular Function for LCN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0036094 small molecule binding IEA --
genes like me logo Genes that share ontologies with LCN15: view
genes like me logo Genes that share phenotypes with LCN15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LCN15
  • Applied Biological Materials Clones for LCN15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCN15 Gene

Localization for LCN15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCN15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCN15 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LCN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LCN15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LCN15 Gene

Pathways & Interactions for LCN15 Gene

genes like me logo Genes that share pathways with LCN15: view

Gene Ontology (GO) - Biological Process for LCN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with LCN15: view

No data available for SIGNOR curated interactions for LCN15 Gene

Drugs & Compounds for LCN15 Gene

No Compound Related Data Available

Transcripts for LCN15 Gene

mRNA/cDNA for LCN15 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCN15 Gene

Lipocalin 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LCN15
  • Applied Biological Materials Clones for LCN15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LCN15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:

Relevant External Links for LCN15 Gene

GeneLoc Exon Structure for
LCN15
ECgene alternative splicing isoforms for
LCN15

Expression for LCN15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCN15 Gene

mRNA differential expression in normal tissues according to GTEx for LCN15 Gene

This gene is overexpressed in Brain - Cortex (x11.7), Brain - Frontal Cortex (BA9) (x10.4), and Brain - Anterior cingulate cortex (BA24) (x5.3).

Protein differential expression in normal tissues from HIPED for LCN15 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LCN15 Gene



Protein tissue co-expression partners for LCN15 Gene

NURSA nuclear receptor signaling pathways regulating expression of LCN15 Gene:

LCN15

SOURCE GeneReport for Unigene cluster for LCN15 Gene:

Hs.413902

Evidence on tissue expression from TISSUES for LCN15 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with LCN15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCN15 Gene

Orthologs for LCN15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LCN15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCN15 33 34
  • 98.91 (n)
cow
(Bos Taurus)
Mammalia LCN15 33 34
  • 84.6 (n)
dog
(Canis familiaris)
Mammalia LCN15 33 34
  • 83.73 (n)
oppossum
(Monodelphis domestica)
Mammalia LCN15 34
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia LOC102636769 33
  • 61.74 (n)
Gm33749 16
platypus
(Ornithorhynchus anatinus)
Mammalia LCN15 34
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALII 33
  • 58.38 (n)
-- 34
  • 35 (a)
ManyToMany
EX-FABP 34
  • 26 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ptgdsa 34
  • 23 (a)
ManyToMany
lcn15 34
  • 19 (a)
ManyToMany
Species where no ortholog for LCN15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LCN15 Gene

ENSEMBL:
Gene Tree for LCN15 (if available)
TreeFam:
Gene Tree for LCN15 (if available)

Paralogs for LCN15 Gene

Paralogs for LCN15 Gene

(2) SIMAP similar genes for LCN15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LCN15: view

Variants for LCN15 Gene

Sequence variations from dbSNP and Humsavar for LCN15 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000047995 -- 136,761,923(+) CAACC(C/T)CTGGG intron-variant
rs1000070715 -- 136,762,149(+) GGAGA(A/G)GCTGG intron-variant
rs1000142633 -- 136,762,363(+) ACTCC(A/G)CCAGC intron-variant
rs1000409757 -- 136,766,370(+) AAATA(C/T)ATAAA upstream-variant-2KB
rs1001080477 -- 136,760,895(+) AACGG(G/T)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LCN15 Gene

Variant ID Type Subtype PubMed ID
esv2422220 CNV deletion 17116639
esv2759720 CNV loss 17122850
esv3891732 CNV loss 25118596
nsv466681 CNV loss 19166990
nsv469918 CNV loss 18288195
nsv615982 CNV loss 21841781
nsv818738 CNV gain 17921354
nsv818739 CNV gain 17921354
nsv8579 CNV gain 18304495
nsv951203 CNV deletion 24416366

Variation tolerance for LCN15 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCN15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCN15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCN15 Gene

Disorders for LCN15 Gene

Relevant External Links for LCN15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCN15

No disorders were found for LCN15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCN15 Gene

Publications for LCN15 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for LCN15 Gene

  • Addgene plasmids for LCN15

Sources for LCN15 Gene

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