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Aliases for LCLAT1 Gene

Aliases for LCLAT1 Gene

  • Lysocardiolipin Acyltransferase 1 2 3 5
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 8 3 4
  • Acyl-CoA:Lysocardiolipin Acyltransferase 1 3 4
  • 1-AGP Acyltransferase 8 3 4
  • 1-AGPAT 8 3 4
  • AGPAT8 3 4
  • ALCAT1 3 4
  • LYCAT 3 4
  • Lysocardiolipin Acyltransferase 2
  • EC 2.3.1.51 4
  • EC 2.3.1.- 4
  • HSRG1849 3
  • 1AGPAT8 3
  • UNQ1849 3

External Ids for LCLAT1 Gene

Previous HGNC Symbols for LCLAT1 Gene

  • LYCAT

Previous GeneCards Identifiers for LCLAT1 Gene

  • GC02P030523
  • GC02P030670
  • GC02P030408

Summaries for LCLAT1 Gene

GeneCards Summary for LCLAT1 Gene

LCLAT1 (Lysocardiolipin Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is AGPAT3.

UniProtKB/Swiss-Prot for LCLAT1 Gene

  • Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCLAT1 Gene

Genomics for LCLAT1 Gene

Regulatory Elements for LCLAT1 Gene

Promoters for LCLAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LCLAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LCLAT1 Gene

Chromosome:
2
Start:
30,447,226 bp from pter
End:
30,644,225 bp from pter
Size:
197,000 bases
Orientation:
Plus strand

Genomic View for LCLAT1 Gene

Genes around LCLAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCLAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCLAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCLAT1 Gene

Proteins for LCLAT1 Gene

  • Protein details for LCLAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWP7-LCLT1_HUMAN
    Recommended name:
    Lysocardiolipin acyltransferase 1
    Protein Accession:
    Q6UWP7
    Secondary Accessions:
    • A6H8Z7
    • Q8N1Q7

    Protein attributes for LCLAT1 Gene

    Size:
    414 amino acids
    Molecular mass:
    48920 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LCLAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCLAT1 Gene

Proteomics data for LCLAT1 Gene at MOPED

Post-translational modifications for LCLAT1 Gene

  • Ubiquitination at Lys 221 and Lys 226
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for LCLAT1

No data available for DME Specific Peptides for LCLAT1 Gene

Domains & Families for LCLAT1 Gene

Gene Families for LCLAT1 Gene

Protein Domains for LCLAT1 Gene

Suggested Antigen Peptide Sequences for LCLAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWP7

UniProtKB/Swiss-Prot:

LCLT1_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LCLAT1: view

Function for LCLAT1 Gene

Molecular function for LCLAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=39 uM for arachidonoyl-CoA (20:4) for LPIAT activity {ECO:0000269 PubMed:19075029}; KM=289 uM for oleoyl-CoA (18:1) for LPIAT activity {ECO:0000269 PubMed:19075029}; KM=134 uM for linoleoyl-CoA (18:2) for LPIAT activity {ECO:0000269 PubMed:19075029}; KM=34 uM for stearoyl-CoA (18:0) for LPIAT activity {ECO:0000269 PubMed:19075029}; KM=53 uM for palmitoyl-CoA (16:0) for LPIAT activity {ECO:0000269 PubMed:19075029}; KM=54 uM for oleoyl-CoA (18:1) for LPGAT activity {ECO:0000269 PubMed:19075029}; KM=36 uM for linoleoyl-CoA (18:2) for LPGAT activity {ECO:0000269 PubMed:19075029}; KM=70 uM for stearoyl-CoA (18:0) for LPGAT activity {ECO:0000269 PubMed:19075029}; KM=34 uM for palmitoyl-CoA (16:0) for LPGAT activity {ECO:0000269 PubMed:19075029}; Vmax=3230 nmol/min/mg enzyme toward arachidonoyl-CoA (20:4) for LPIAT activity {ECO:0000269 PubMed:19075029}; Vmax=7489 nmol/min/mg enzyme toward oleoyl-CoA (18:1) for LPIAT activity {ECO:0000269 PubMed:19075029}; Vmax=4696 nmol/min/mg enzyme toward linoleoyl-CoA (18:2) for LPIAT activity {ECO:0000269 PubMed:19075029}; Vmax=1078 nmol/min/mg enzyme toward stearoyl-CoA (18:0) for LPIAT activity {ECO:0000269 PubMed:19075029}; Vmax=11203 nmol/min/mg enzyme toward palmitoyl-CoA (16:0) for LPIAT activity {ECO:0000269 PubMed:19075029}; Vmax=5514 nmol/min/mg enzyme toward oleoyl-CoA (18:1) for LPGAT activity {ECO:0000269 PubMed:19075029}; Vmax=1358 nmol/min/mg enzyme toward linoleoyl-CoA (18:2) for LPGAT activity {ECO:0000269 PubMed:19075029}; Vmax=3530 nmol/min/mg enzyme toward stearoyl-CoA (18:0) for LPGAT activity {ECO:0000269 PubMed:19075029}; Vmax=1673 nmol/min/mg enzyme toward palmitoyl-CoA (16:0) for LPGAT activity {ECO:0000269 PubMed:19075029};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.

Enzyme Numbers (IUBMB) for LCLAT1 Gene

genes like me logo Genes that share phenotypes with LCLAT1: view

Animal Models for LCLAT1 Gene

MGI Knock Outs for LCLAT1:

Animal Model Products

CRISPR Products

miRNA for LCLAT1 Gene

miRTarBase miRNAs that target LCLAT1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LCLAT1 Gene

Localization for LCLAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCLAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCLAT1 Gene COMPARTMENTS Subcellular localization image for LCLAT1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 2
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for LCLAT1 Gene

Pathways & Interactions for LCLAT1 Gene

genes like me logo Genes that share pathways with LCLAT1: view

UniProtKB/Swiss-Prot Q6UWP7-LCLT1_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

Gene Ontology (GO) - Biological Process for LCLAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016024 CDP-diacylglycerol biosynthetic process IEA --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with LCLAT1: view

No data available for SIGNOR curated interactions for LCLAT1 Gene

Drugs & Compounds for LCLAT1 Gene

(2) Drugs for LCLAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(149) Additional Compounds for LCLAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with LCLAT1: view

Transcripts for LCLAT1 Gene

Unigene Clusters for LCLAT1 Gene

Lysocardiolipin acyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LCLAT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for LCLAT1 Gene

GeneLoc Exon Structure for
LCLAT1
ECgene alternative splicing isoforms for
LCLAT1

Expression for LCLAT1 Gene

mRNA expression in normal human tissues for LCLAT1 Gene

Protein differential expression in normal tissues from HIPED for LCLAT1 Gene

This gene is overexpressed in Testis (9.0) and Lung (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LCLAT1 Gene



SOURCE GeneReport for Unigene cluster for LCLAT1 Gene Hs.468048

mRNA Expression by UniProt/SwissProt for LCLAT1 Gene

Q6UWP7-LCLT1_HUMAN
Tissue specificity: Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta.
genes like me logo Genes that share expression patterns with LCLAT1: view

Protein tissue co-expression partners for LCLAT1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LCLAT1 Gene

Orthologs for LCLAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LCLAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCLAT1 35
  • 99.6 (n)
  • 99.52 (a)
LCLAT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LCLAT1 36
  • 88 (a)
OneToOne
LCLAT1 35
  • 89.54 (n)
  • 91.22 (a)
dog
(Canis familiaris)
Mammalia LCLAT1 35
  • 91.31 (n)
  • 93.09 (a)
LCLAT1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lclat1 16
Lclat1 36
  • 89 (a)
OneToOne
Lclat1 35
  • 84.84 (n)
  • 89.1 (a)
oppossum
(Monodelphis domestica)
Mammalia LCLAT1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCLAT1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lclat1 35
  • 85.15 (n)
  • 89.66 (a)
chicken
(Gallus gallus)
Aves LCLAT1 36
  • 75 (a)
OneToOne
LCLAT1 35
  • 76.29 (n)
  • 76.2 (a)
lizard
(Anolis carolinensis)
Reptilia LCLAT1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lclat1 35
  • 73.3 (n)
  • 77.9 (a)
zebrafish
(Danio rerio)
Actinopterygii lycat 35
  • 60.5 (n)
  • 64.09 (a)
worm
(Caenorhabditis elegans)
Secernentea acl-8 35
  • 49.25 (n)
  • 43.21 (a)
acl-8 36
  • 38 (a)
OneToMany
acl-9 36
  • 32 (a)
OneToMany
bus-18 36
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 18 (a)
ManyToMany
CST26 36
  • 20 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LPAT5 35
  • 45.58 (n)
  • 34.85 (a)
rice
(Oryza sativa)
Liliopsida Os05g0502200 35
  • 44.54 (n)
  • 34.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12405 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for LCLAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LCLAT1 Gene

ENSEMBL:
Gene Tree for LCLAT1 (if available)
TreeFam:
Gene Tree for LCLAT1 (if available)

Paralogs for LCLAT1 Gene

Paralogs for LCLAT1 Gene

genes like me logo Genes that share paralogs with LCLAT1: view

Variants for LCLAT1 Gene

Sequence variations from dbSNP and Humsavar for LCLAT1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11648 -- 30,643,176(+) GACAC(A/G)GTTCC utr-variant-3-prime
rs829562 -- 30,472,890(-) GTTTC(A/G)TCTAA intron-variant
rs829563 -- 30,472,631(-) TTAAA(A/T)TGACT intron-variant
rs829568 -- 30,464,559(+) AAGAA(C/T)GCTCT intron-variant
rs829570 -- 30,461,423(-) aaaCA(C/G)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LCLAT1 Gene

Variant ID Type Subtype PubMed ID
nsv833648 CNV Gain 17160897
esv271415 CNV Insertion 20981092
esv2667252 CNV Deletion 23128226
dgv689e199 CNV Deletion 23128226
esv2719865 CNV Deletion 23290073
nsv524988 CNV Loss 19592680
esv2719866 CNV Deletion 23290073
esv2719867 CNV Deletion 23290073
esv2657230 CNV Deletion 23128226
nsv215004 CNV Loss 16902084

Variation tolerance for LCLAT1 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCLAT1 Gene

HapMap Linkage Disequilibrium report
LCLAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCLAT1 Gene

Disorders for LCLAT1 Gene

Relevant External Links for LCLAT1

Genetic Association Database (GAD)
LCLAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCLAT1

No disorders were found for LCLAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCLAT1 Gene

Publications for LCLAT1 Gene

  1. Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. (PMID: 16620771) Agarwal A.K. … Garg A. (Arch. Biochem. Biophys. 2006) 2 3 4 23 67
  2. The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids. (PMID: 19075029) Zhao Y. … Cao G. (J. Lipid Res. 2009) 3 23
  3. Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. (PMID: 17675553) Wang C. … Xiong J.W. (Blood 2007) 2 3
  4. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. (PMID: 15152008) Cao J. … Shi Y. (J. Biol. Chem. 2004) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for LCLAT1 Gene

Sources for LCLAT1 Gene

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