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Aliases for LCK Gene

Aliases for LCK Gene

  • LCK Proto-Oncogene, Src Family Tyrosine Kinase 2 3 5
  • Lymphocyte Cell-Specific Protein-Tyrosine Kinase 3 4
  • T Cell-Specific Protein-Tyrosine Kinase 3 4
  • Leukocyte C-Terminal Src Kinase 3 4
  • EC 2.7.10.2 4 61
  • LSK 3 4
  • T-Lymphocyte Specific Protein Tyrosine Kinase P56lck 3
  • Lymphocyte-Specific Protein Tyrosine Kinase 2
  • Proto-Oncogene Tyrosine-Protein Kinase LCK 3
  • P56(LSTRA) Protein-Tyrosine Kinase 3
  • Tyrosine-Protein Kinase Lck 3
  • Proto-Oncogene Lck 4
  • Protein YT16 4
  • EC 2.7.10 61
  • Pp58lck 3
  • P56-LCK 4
  • P56lck 3
  • IMD22 3
  • YT16 3

External Ids for LCK Gene

Previous GeneCards Identifiers for LCK Gene

  • GC01U990096
  • GC01P032143
  • GC01P032219
  • GC01P032386
  • GC01P032489
  • GC01P032716
  • GC01P030833

Summaries for LCK Gene

Entrez Gene Summary for LCK Gene

  • This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]

GeneCards Summary for LCK Gene

LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with LCK include Immunodeficiency 22 and Cd45 Deficiency. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is HCK.

UniProtKB/Swiss-Prot for LCK Gene

  • Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with ARAP (PubMed:27335501).

Tocris Summary for LCK Gene

  • Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.

Gene Wiki entry for LCK Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCK Gene

Genomics for LCK Gene

Regulatory Elements for LCK Gene

Enhancers for LCK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G032246 2 FANTOM5 Ensembl ENCODE dbSUPER 14.2 +1.3 1272 11.9 CREB3L1 MLX DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MTMR9LP LCK ZBTB8B LRRC37A12P CCDC28B BSDC1 PTP4A2 GC01M032258
GH01G032262 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.7 +14.1 14149 4.8 HDGF ZNF493 ZFP64 ZNF121 GATA2 FOS REST ZNF623 ZNF518A MEF2D SNRNP40 EIF3I MTMR9LP ZBTB8B KPNA6 TSSK3 DCDC2B ENSG00000270115 LCK TXLNA
GH01G032178 1.2 ENCODE 10.7 -70.9 -70895 4.1 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC KPNA6 ENSG00000224066 IQCC DCDC2B TMEM234 EIF3I HDAC1 MARCKSL1 LCK FAM167B
GH01G032106 1.1 ENCODE 10.2 -143.1 -143088 3.0 HDGF CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ENSG00000203325 TMEM39B CCDC28B IQCC LCK FAM167B KPNA6 LRRC37A12P PIR55954
GH01G032316 0.8 ENCODE 11.6 +65.8 65808 1.8 CTCF PKNOX1 LEF1 KLF1 RB1 RAD21 ZNF143 SMC3 NR2F6 FOS HDAC1 LCK FAM167B IQCC ENSG00000224066 TMEM234 EIF3I DCDC2B LOC105378629 MARCKSL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LCK on UCSC Golden Path with GeneCards custom track

Genomic Location for LCK Gene

Chromosome:
1
Start:
32,251,239 bp from pter
End:
32,286,170 bp from pter
Size:
34,932 bases
Orientation:
Plus strand

Genomic View for LCK Gene

Genes around LCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCK Gene

Proteins for LCK Gene

  • Protein details for LCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06239-LCK_HUMAN
    Recommended name:
    Tyrosine-protein kinase Lck
    Protein Accession:
    P06239
    Secondary Accessions:
    • D3DPP8
    • P07100
    • Q12850
    • Q13152
    • Q5TDH8
    • Q5TDH9
    • Q7RTZ3
    • Q96DW4
    • Q9NYT8

    Protein attributes for LCK Gene

    Size:
    509 amino acids
    Molecular mass:
    58001 Da
    Quaternary structure:
    • Binds to the cytoplasmic domain of cell surface receptors, such as AXL, CD2, CD4, CD5, CD8, CD44, CD45 and CD122. Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB and to other protein kinases including CDK1, RAF1, ZAP70 and SYK. Binds to phosphatidylinositol 3-kinase (PI3K) from T-lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of KHDRBS1/p70 through its SH2 domain. Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with herpes simplex virus 1 UL46; this interaction activates LCK. Interacts with SQSTM1. Interacts with phosphorylated LIME1. Interacts with CBLB and PTPRH. Interacts with RUNX3. Forms a signaling complex with EPHA1, PTK2B AND PI3-KINASE; upon activation by EFNA1 which may regulate T-lymphocyte migration. Associates with ZAP70 and RHOH; these interactions allow LCK-mediated RHOH and CD3 subunit phosphorylation in the presence of functional ZAP70. Interacts with UNC119; this interaction plays a crucial role in activation of LCK. Interacts with CEACAM1 (via cytoplasmic domain); mediates CEACAM1 phosphorylation resulting in PTPN6 recruitment that dephosphorylates TCR stimulation-induced CD247 and ZAP70 (PubMed:18424730).
    SequenceCaution:
    • Sequence=CAI22320.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI22321.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LCK Gene

    Alternative splice isoforms for LCK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCK Gene

Selected DME Specific Peptides for LCK Gene

P06239:
  • KWTAPEA
  • LVRHYTNASDGLCT
  • DMAAQIA
  • DEWEVPR
  • TATEGQYQ
  • IKSDVWSFGILL
  • PYPGMTN
  • FLIRESE
  • NYIHRDLR
  • FTIKSDVWSFG
  • TQKPQKPWW
  • CKIADFGLAR
  • RKDAERQLL
  • GQFGEVW
  • NCPEELY
  • LVRLYAVV
  • VKHYKIR
  • ADFGLARLIED
  • LSVRDFD
  • GRIPYPGM
  • HRDLRAANILV
  • YISPRITFP
  • EPIYIITE
  • KSDVWSFG
  • AQSLTTGQEG
  • LKQGSMSP
  • EIVTHGR
  • KFPIKWTAPE
  • GSLVDFLKT
  • AQIAEGMA
  • LGAGQFGEV
  • NSLEPEPWFFKNLSRK
  • SEVRDPLV
  • PSHDGDLGFEKGEQLRILEQ
  • PIYIITE
  • YNGHTKVA

Post-translational modifications for LCK Gene

  • Autophosphorylated on Tyr-394, increasing enzymatic activity, this site is dephosphorylated by PTN22. Phosphorylated on Tyr-505 by CSK, decreasing activity. Dephosphorylated by PTPRC/CD45. Dephosphorylation at Tyr-394 by PTPN2 negatively regulates T-cell receptor signaling.
  • Myristoylation is required prior to palmitoylation.
  • Palmitoylation regulates subcellular location.
  • Ubiquitination at posLast=9999, posLast=118118, isoforms=3, 2130, posLast=179179, isoforms=3, 2269, isoforms=3, 2276, isoforms=3, 2293, posLast=379379, isoforms=3401, and isoforms=3405
  • Modification sites at PhosphoSitePlus

Domains & Families for LCK Gene

Suggested Antigen Peptide Sequences for LCK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06239

UniProtKB/Swiss-Prot:

LCK_HUMAN :
  • The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with LCK: view

Function for LCK Gene

Molecular function for LCK Gene

GENATLAS Biochemistry:
breakpoint in T-cell acute lymphoblastic leukemia with translocations t(1;7)(p34;q34)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
The relative activities of the inhibitory tyrosine-protein kinase CSK and the activating tyrosine-protein phosphatase PTPRC/CD45 determine the level of LCK activity. These interactions allow rapid and efficient activation of LCK in response to TCR stimulation.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with ARAP (PubMed:27335501).

Enzyme Numbers (IUBMB) for LCK Gene

Gene Ontology (GO) - Molecular Function for LCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IPI 20624904
GO:0001948 glycoprotein binding IPI 7513706
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA,IEA --
genes like me logo Genes that share ontologies with LCK: view
genes like me logo Genes that share phenotypes with LCK: view

Human Phenotype Ontology for LCK Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LCK Gene

MGI Knock Outs for LCK:

Animal Model Products

  • Taconic Biosciences Mouse Models for LCK

miRNA for LCK Gene

miRTarBase miRNAs that target LCK

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LCK

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for LCK Gene

Localization for LCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCK Gene

Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Present in lipid rafts in an inactive form.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCK gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
golgi apparatus 3
mitochondrion 2
nucleus 2
endosome 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material ISS --
GO:0001772 immunological synapse IDA 20007709
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with LCK: view

Pathways & Interactions for LCK Gene

genes like me logo Genes that share pathways with LCK: view

SIGNOR curated interactions for LCK Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for LCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,IEA 214242
GO:0006470 protein dephosphorylation IEA --
GO:0006882 cellular zinc ion homeostasis ISS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
genes like me logo Genes that share ontologies with LCK: view

Drugs & Compounds for LCK Gene

(68) Drugs for LCK Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Inhibition, inhibitor, Target, multitarget Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 285
Nintedanib Approved Pharma Target, Inhibitor VEGFR, FGFR, PDGFR, and FLT3 inhibitor, Kinase Inhibitors 116
ponatinib Approved Pharma Target, inhibitor Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors 32
Pazopanib Approved Pharma VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Iclusig Approved December 2012 Pharma 0

(39) Additional Compounds for LCK Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
PP 2
172889-27-9

(5) Tocris Compounds for LCK Gene

Compound Action Cas Number
A 419259 trihydrochloride Inhibitor of Src family kinases 1435934-25-0
KB SRC 4 Potent and selective c-Src inhibitor 1380088-03-8
PP 1 Potent, selective Src family kinase inhibitor 172889-26-8
PP 2 Potent, selective Src family kinase inhibitor 172889-27-9
Src I1 Dual site Src kinase inhibitor 179248-59-0

(12) ApexBio Compounds for LCK Gene

Compound Action Cas Number
1-NM-PP1 Pp60c-src inhibitor 221244-14-0
A 419259 Lck inhibitor 364042-47-7
A 419259 trihydrochloride LCK inhibitor, orally available 1435934-25-0
A-770041 Selective Lck inhibitor 869748-10-7
BIBF 1120 VEGFR/PDGF/FGFR inhibitor 656247-17-5
KX2-391 Src inhibitor,highly selective 897016-82-9
Lck Inhibitor Lck inhibitor 847950-09-8
NVP-BHG712 EphB4 inhibitor,potent and selective 940310-85-0
OSI-930 Inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck 728033-96-3
PP 1 Src family tyrosine kinase inhibitor 172889-26-8
PP 2 (AG 1879) Src-family kinases inhibitor 172889-27-9
WH-4-023 Lck/Src inhibitor,potent and selective 837422-57-8
genes like me logo Genes that share compounds with LCK: view

Drug Products

Transcripts for LCK Gene

Unigene Clusters for LCK Gene

Lymphocyte-specific protein tyrosine kinase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LCK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCK Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^
SP1: - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: - - - - - -
SP8: -
SP9: - -
SP10: - - - - -
SP11: - - - -

ExUns: 12 ^ 13 ^ 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for LCK Gene

GeneLoc Exon Structure for
LCK
ECgene alternative splicing isoforms for
LCK

Expression for LCK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCK Gene

This gene is overexpressed in Whole Blood (x21.8), Spleen (x5.8), and Small Intestine - Terminal Ileum (x4.0).

Protein differential expression in normal tissues from HIPED for LCK Gene

This gene is overexpressed in Lymph node (20.5), CD8 Tcells (17.3), Peripheral blood mononuclear cells (10.2), and Tlymphocyte (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LCK Gene



Protein tissue co-expression partners for LCK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LCK Gene:

LCK

SOURCE GeneReport for Unigene cluster for LCK Gene:

Hs.470627

mRNA Expression by UniProt/SwissProt for LCK Gene:

P06239-LCK_HUMAN
Tissue specificity: Expressed specifically in lymphoid cells.

Evidence on tissue expression from TISSUES for LCK Gene

  • Blood(4.8)
  • Bone marrow(3)
  • Spleen(3)
  • Lymph node(2.7)
  • Intestine(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LCK Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • integumentary
  • lymphatic
  • respiratory
Organs:
Abdomen:
  • intestine
  • large intestine
  • small intestine
General:
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with LCK: view

Primer Products

Orthologs for LCK Gene

This gene was present in the common ancestor of animals.

Orthologs for LCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCK 34 35
  • 98.56 (n)
oppossum
(Monodelphis domestica)
Mammalia LCK 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LCK 34 35
  • 92.99 (n)
cow
(Bos Taurus)
Mammalia LCK 34 35
  • 91.94 (n)
mouse
(Mus musculus)
Mammalia Lck 34 16 35
  • 88.8 (n)
rat
(Rattus norvegicus)
Mammalia Lck 34
  • 88.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LCK 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves LCK 34 35
  • 80.18 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia lck 34
  • 69.94 (n)
zebrafish
(Danio rerio)
Actinopterygii lck 34 35
  • 67.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta Src64B 36
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea src-1 36
  • 44 (a)
C24G6.2a 36
  • 37 (a)
C24G6.2b 36
  • 37 (a)
kin-9 36
  • 36 (a)
kin-26 36
  • 31 (a)
F09A5.2 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
Species where no ortholog for LCK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LCK Gene

ENSEMBL:
Gene Tree for LCK (if available)
TreeFam:
Gene Tree for LCK (if available)

Paralogs for LCK Gene

Variants for LCK Gene

Sequence variations from dbSNP and Humsavar for LCK Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs587777335 Pathogenic, Immunodeficiency 22 (IMD22) [MIM:615758] 32,279,728(+) CAAAC(C/T)CCTGG reference, missense
rs1000065202 -- 32,268,578(+) CAAAA(C/T)ATATC intron-variant
rs1000131336 -- 32,269,295(+) TAGCT(A/G)GGCGT intron-variant
rs1000167280 -- 32,264,438(+) AAGCG(C/T)TTGAG intron-variant
rs1000198232 -- 32,264,727(+) GCTAC(C/T)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LCK Gene

Variant ID Type Subtype PubMed ID
nsv1077305 CNV deletion 25765185
nsv1112528 CNV deletion 24896259

Variation tolerance for LCK Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCK Gene

Human Gene Mutation Database (HGMD)
LCK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCK Gene

Disorders for LCK Gene

MalaCards: The human disease database

(14) MalaCards diseases for LCK Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 22
  • imd22
cd45 deficiency
epithelial malignant thymoma
  • squamoid thymoma
thymoma
  • thymus neoplasms
dendritic cell thymoma
  • epithelioid thymoma
- elite association - COSMIC cancer census association via MalaCards
Search LCK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LCK_HUMAN
  • Immunodeficiency 22 (IMD22) [MIM:615758]: A primary immunodeficiency characterized by T-cell dysfunction. Affected individuals present with lymphopenia, recurrent infections, severe diarrhea, and failure to thrive. {ECO:0000269 PubMed:22985903}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving LCK is found in leukemias. Translocation t(1;7)(p34;q34) with TCRB.

Relevant External Links for LCK

Genetic Association Database (GAD)
LCK
Human Genome Epidemiology (HuGE) Navigator
LCK
Tumor Gene Database (TGDB):
LCK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCK
genes like me logo Genes that share disorders with LCK: view

No data available for Genatlas for LCK Gene

Publications for LCK Gene

  1. Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function. (PMID: 12837766) Ito T. … Matozaki T. (J. Biol. Chem. 2003) 3 4 22 64
  2. No association between lck gene polymorphisms and protein level in type 1 diabetes. (PMID: 12401726) Nervi S. … Vialettes B. (Diabetes 2002) 3 4 46 64
  3. Human immunodeficiency virus type 1 Nef binds directly to LCK and mitogen-activated protein kinase, inhibiting kinase activity. (PMID: 8794306) Greenway A.L. … McPhee D.A. (J. Virol. 1996) 3 4 22 64
  4. p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T- lymphocytes. (PMID: 7852312) Vogel L.B. … Fujita D.J. (J. Biol. Chem. 1995) 3 4 22 64
  5. Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. (PMID: 8618896) Park I. … Shin J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 22 64

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