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Aliases for LCK Gene

Aliases for LCK Gene

  • LCK Proto-Oncogene, Src Family Tyrosine Kinase 2 3
  • Lymphocyte Cell-Specific Protein-Tyrosine Kinase 3 4
  • Lymphocyte-Specific Protein Tyrosine Kinase 2 3
  • T Cell-Specific Protein-Tyrosine Kinase 3 4
  • Leukocyte C-Terminal Src Kinase 3 4
  • EC 2.7.10.2 4 63
  • Lsk 3 4
  • T-Lymphocyte Specific Protein Tyrosine Kinase P56lck 3
  • Proto-Oncogene Tyrosine-Protein Kinase LCK 3
  • P56(LSTRA) Protein-Tyrosine Kinase 3
  • Tyrosine-Protein Kinase Lck 3
  • Proto-Oncogene Lck 4
  • Protein YT16 4
  • EC 2.7.10 63
  • Pp58lck 3
  • P56-LCK 4
  • P56lck 3
  • IMD22 3
  • YT16 3

External Ids for LCK Gene

Previous GeneCards Identifiers for LCK Gene

  • GC01U990096
  • GC01P032143
  • GC01P032219
  • GC01P032386
  • GC01P032489
  • GC01P032716
  • GC01P030833

Summaries for LCK Gene

Entrez Gene Summary for LCK Gene

  • This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for LCK Gene

LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with LCK include immunodeficiency 22 and severe combined immunodeficiency due to lck deficiency. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for LCK Gene

  • Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP.

Tocris Summary for LCK Gene

  • Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure with a high degree of homology in the SH1 (catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association) domains. c-Src, Fyn and Yes are ubiquitously expressed, although high levels of c-Src are found in platelets, neural tissue and osteoclasts. For c-Src, autophosphorylation of Tyr418 and dephosphorylation of Tyr530 is required to switch the kinase from the inactive closed formation to the active open formation. c-Src can be inactivated by two kinases, c-Src kinase (CSK) and CSK homologous kinase (CHK), both of which phosphorylate Tyr530 of c-Src. The activity of the Src kinase family can also be regulated by phosphatases (e.g. SHP1), binding to adaptor proteins (e.g. Cbp) and proteasomal degradation. Src kinases are key upstream mediators of both the PI 3-K and MAPK signaling pathways, and have been shown to have important roles in cell proliferation, migration and survival.

Gene Wiki entry for LCK Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCK Gene

Genomics for LCK Gene

Regulatory Elements for LCK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LCK Gene

Start:
32,251,239 bp from pter
End:
32,286,165 bp from pter
Size:
34,927 bases
Orientation:
Plus strand

Genomic View for LCK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCK Gene

Proteins for LCK Gene

  • Protein details for LCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06239-LCK_HUMAN
    Recommended name:
    Tyrosine-protein kinase Lck
    Protein Accession:
    P06239
    Secondary Accessions:
    • D3DPP8
    • P07100
    • Q12850
    • Q13152
    • Q5TDH8
    • Q5TDH9
    • Q7RTZ3
    • Q96DW4
    • Q9NYT8

    Protein attributes for LCK Gene

    Size:
    509 amino acids
    Molecular mass:
    58001 Da
    Quaternary structure:
    • Binds to the cytoplasmic domain of cell surface receptors, such as AXL, CD2, CD4, CD5, CD8, CD44, CD45 and CD122. Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB and to other protein kinases including CDK1, RAF1, ZAP70 and SYK. Binds to phosphatidylinositol 3-kinase (PI3K) from T-lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of KHDRBS1/p70 through its SH2 domain. Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with herpes simplex virus 1 UL46; this interaction acitivates LCK. Interacts with SQSTM1. Interacts with phosphorylated LIME1. Interacts with CBLB and PTPRH. Interacts with RUNX3. Forms a signaling complex with EPHA1, PTK2B AND PI3-KINASE; upon activation by EFNA1 which may regulate T-lymphocyte migration. Associates with ZAP70 and RHOH; these interactions allow LCK-mediated RHOH and CD3 subunit phosphorylation in the presence of functional ZAP70. Interacts with UNC119; this interaction plays a crucial role in activation of LCK.
    SequenceCaution:
    • Sequence=CAI22320.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI22321.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LCK Gene

    Alternative splice isoforms for LCK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LCK Gene

Proteomics data for LCK Gene at MOPED

Post-translational modifications for LCK Gene

  • Autophosphorylated on Tyr-394, increasing enzymatic activity, this site is dephosphorylated by PTN22. Phosphorylated on Tyr-505 by CSK, decreasing activity. Dephosphorylated by PTPRC/CD45. Dephosphorylation at Tyr-394 by PTPN2 negatively regulates T-cell receptor signaling.
  • Myristoylation is required prior to palmitoylation.
  • Palmitoylation regulates subcellular location.
  • Ubiquitination at Lys99, Lys118, Lys130, Lys179, Lys269, Lys276, Lys293, Lys379, Lys401, and Lys405
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LCK (Lck)

Domains for LCK Gene

Gene Families for LCK Gene

HGNC:
  • SH2D :SH2 domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for LCK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06239

UniProtKB/Swiss-Prot:

LCK_HUMAN :
  • P06239
Domain:
  • The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with LCK: view

Function for LCK Gene

Molecular function for LCK Gene

GENATLAS Biochemistry: breakpoint in T-cell acute lymphoblastic leukemia with translocations t(1;7)(p34;q34)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: The relative activities of the inhibitory tyrosine-protein kinase CSK and the activating tyrosine-protein phosphatase PTPRC/CD45 determine the level of LCK activity. These interactions allow rapid and efficient activation of LCK in response to TCR stimulation.
UniProtKB/Swiss-Prot Function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP.

Enzyme Numbers (IUBMB) for LCK Gene

Gene Ontology (GO) - Molecular Function for LCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 14625311
GO:0003823 antigen binding IEA --
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
genes like me logo Genes that share ontologies with LCK: view
genes like me logo Genes that share phenotypes with LCK: view

Animal Models for LCK Gene

MGI Knock Outs for LCK:

Animal Model Products

CRISPR Products

miRNA for LCK Gene

miRTarBase miRNAs that target LCK

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LCK

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for LCK Gene

Localization for LCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for LCK Gene

Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Present in lipid rafts in an inactive form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCK Gene COMPARTMENTS Subcellular localization image for LCK gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
endosome 2
extracellular 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material ISS --
GO:0001772 immunological synapse IDA 20007709
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with LCK: view

Pathways for LCK Gene

SuperPathways for LCK Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 CD28 co-stimulation
4 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
5 Immune response NFAT in immune response
genes like me logo Genes that share pathways with LCK: view

PCR Array Products

Gene Ontology (GO) - Biological Process for LCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 214242
GO:0006882 cellular zinc ion homeostasis ISS --
GO:0006915 apoptotic process --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS --
GO:0007166 cell surface receptor signaling pathway --
genes like me logo Genes that share ontologies with LCK: view

Compounds for LCK Gene

(5) Tocris Compounds for LCK Gene

Compound Action Cas Number
1-Naphthyl PP1 Src family kinase inhibitor; also inhibits c-Abl [221243-82-9]
KB SRC 4 Potent and selective c-Src inhibitor [1380088-03-8]
PP 2 Potent, selective Src family kinase inhibitor [172889-27-9]
PP 3 Negative control for PP 2 (Cat. No. 1407) [5334-30-5]
Src I1 Dual site Src kinase inhibitor [179248-59-0]

(3) HMDB Compounds for LCK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2

(68) Novoseek inferred chemical compound relationships for LCK Gene

Compound -log(P) Hits PubMed IDs
tyrosine 90.7 255
phosphotyrosine 80 31
herbimycin a 73.6 7
damnacanthal 70 5
a 201 57.7 1

(1) PharmGKB related drug/compound annotations for LCK Gene

Drug/compound Annotation
pazopanib
genes like me logo Genes that share compounds with LCK: view

Transcripts for LCK Gene

Unigene Clusters for LCK Gene

Lymphocyte-specific protein tyrosine kinase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LCK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCK Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^
SP1: - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: - - - - - -
SP8: -
SP9: - -
SP10: - - - - -
SP11: - - - -

ExUns: 12 ^ 13 ^ 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for LCK Gene

GeneLoc Exon Structure for
LCK
ECgene alternative splicing isoforms for
LCK

Expression for LCK Gene

mRNA expression in normal human tissues for LCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LCK Gene

This gene is overexpressed in Whole Blood (21.8), Spleen (5.8), and Small Intestine - Terminal Ileum (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LCK Gene

SOURCE GeneReport for Unigene cluster for LCK Gene Hs.470627

mRNA Expression by UniProt/SwissProt for LCK Gene

P06239-LCK_HUMAN
Tissue specificity: Expressed specifically in lymphoid cells
genes like me logo Genes that share expressions with LCK: view

In Situ Assay Products

Orthologs for LCK Gene

This gene was present in the common ancestor of animals.

Orthologs for LCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCK 35
  • 98.56 (n)
  • 98.39 (a)
LCK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LCK 35
  • 91.94 (n)
  • 96.27 (a)
LCK 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LCK 35
  • 92.99 (n)
  • 97.45 (a)
LCK 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lck 35
  • 88.8 (n)
  • 96.86 (a)
Lck 16
Lck 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LCK 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LCK 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lck 35
  • 88.21 (n)
  • 96.66 (a)
chicken
(Gallus gallus)
Aves LCK 35
  • 80.18 (n)
  • 82.87 (a)
LCK 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lck 35
  • 69.94 (n)
  • 76.42 (a)
zebrafish
(Danio rerio)
Actinopterygii lck 35
  • 67.54 (n)
  • 71.29 (a)
lck 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Src64B 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea src-1 37
  • 44 (a)
kin-9 37
  • 36 (a)
F09A5.2 37
  • 29 (a)
C24G6.2a 37
  • 37 (a)
kin-26 37
  • 31 (a)
C24G6.2b 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
Species with no ortholog for LCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LCK Gene

ENSEMBL:
Gene Tree for LCK (if available)
TreeFam:
Gene Tree for LCK (if available)

Paralogs for LCK Gene

Paralogs for LCK Gene

genes like me logo Genes that share paralogs with LCK: view

Variants for LCK Gene

Sequence variations from dbSNP and Humsavar for LCK Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs640492 -- 32,267,487(-) caccg(C/T)gccca intron-variant
rs656225 -- 32,266,281(-) tctcc(C/T)gacct intron-variant
rs656259 -- 32,266,245(-) aaagt(G/T)ctggg intron-variant
rs656271 -- 32,266,237(-) gggat(C/G)acagg intron-variant
rs670025 -- 32,265,473(-) GGCAG(A/T)TCCTG intron-variant

Relevant External Links for LCK Gene

HapMap Linkage Disequilibrium report
LCK
Human Gene Mutation Database (HGMD)
LCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LCK Gene

Disorders for LCK Gene

UniProtKB/Swiss-Prot

LCK_HUMAN
  • Note=A chromosomal aberration involving LCK is found in leukemias. Translocation t(1;7)(p34;q34) with TCRB.
  • Immunodeficiency 22 (IMD22) [MIM:615758]: A primary immunodeficiency characterized by T-cell dysfunction. Affected individuals present with lymphopenia, recurrent infections, severe diarrhea, and failure to thrive. {ECO:0000269 PubMed:22985903}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for LCK Gene

(50) Novoseek inferred disease relationships for LCK Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 65 17
immunodeficiency 34.3 14
thymoma 29.9 3
t-all 23.1 3
lymphoma t-cell 22.4 2

Relevant External Links for LCK

Genetic Association Database (GAD)
LCK
Human Genome Epidemiology (HuGE) Navigator
LCK
Tumor Gene Database (TGDB):
LCK
genes like me logo Genes that share disorders with LCK: view

Publications for LCK Gene

  1. p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T- lymphocytes. (PMID: 7852312) Vogel L.B. … Fujita D.J. (J. Biol. Chem. 1995) 3 4 23
  2. Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia. (PMID: 8139546) Wright D.D. … Kamps M.P. (Mol. Cell. Biol. 1994) 3 4 23
  3. Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. (PMID: 8618896) Park I. … Shin J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  4. Human immunodeficiency virus type 1 Nef binds directly to LCK and mitogen-activated protein kinase, inhibiting kinase activity. (PMID: 8794306) Greenway A.L. … McPhee D.A. (J. Virol. 1996) 3 4 23
  5. Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function. (PMID: 12837766) Ito T. … Matozaki T. (J. Biol. Chem. 2003) 3 4 23

Products for LCK Gene

  • Addgene plasmids for LCK

Sources for LCK Gene

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