LCE6A Gene
protein-coding GIFtS: 31
GCID: GC01P152815
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late cornified envelope 6A(Previous name: chromosome 1 open reading frame 44 )
(Previous symbol: C1orf44)
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Aliases
for LCE6A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Late Cornified Envelope 6A1 2 | | C1orf441 2 3 | | Chromosome 1 Open Reading Frame 441 | | Late Cornified Envelope Protein 6A2 |
Export aliases for LCE6A gene to outside databasesPrevious GC identifers: GC01U901418 GC01P151082 GC01P124178 |
Summaries
for LCE6A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LCE6A_HUMAN, A0A183Function: Precursors of the cornified envelope of the stratum corneum (By similarity)
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Genomic Views
for LCE6A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LCE6A gene promoter:
TBP Sox5 C/EBPbeta AML1a NCX/Ncx C/EBPalpha CHOP-10 SRY Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LCE6A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCE6A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3LCE6A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P152815: view genomic region
(about GC identifiers)
Start:
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152,815,330 bp from pter |
End:
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152,816,459 bp from pter |
Size:
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1,130 bases |
Orientation:
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plus strand |
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Proteins
for LCE6A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LCE6A_HUMAN, A0A183 (See
protein sequence)Recommended Name: Late cornified envelope protein 6A Size: 80 amino acids; 9022 Da
Miscellaneous: Belongs to the LCE cluster present on 1q21Explore the universe of human proteins at neXtProt for LCE6A: NX_A0A183
LCE6A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001122072.1
ENSEMBL proteins: ENSP00000411070
Human Recombinant Protein Products:
LCE6A Antibody Products:
Assay Products for LCE6A: |
Protein
Domains /
Families
for LCE6A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: A0A183 UniProtKB/Swiss-Prot: LCE6A_HUMAN, A0A183Similarity: Belongs to the LCE family |
Function
for LCE6A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LCE6A_HUMAN, A0A183Function: Precursors of the cornified envelope of the stratum corneum (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCE6A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCE6A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LCE6A (NM_001128600) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LCE6A | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LCE6A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCE6A |
|
Pathways & Interactions
for LCE6A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LCE6A
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031424 | keratinization |
IEA | -- |
LCE6A for ontologies About GeneDecksing
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Drugs & Compounds
for LCE6A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LCE6A
Search CenterWatch for drugs/clinical trials and news about LCE6A
|
Transcripts
for LCE6A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LCE6A gene: NM_001128600.1 Unigene Cluster for LCE6A: Late cornified envelope 6A Hs.62927 [show with all ESTs]Unigene Representative Sequence: NM_0011286001 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000431011(uc001fas.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCE6A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCE6A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LCE6A (NM_001128600) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LCE6A | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LCE6A |
Additional cDNA sequence: DQ991251.1 1 DOTS entry: DT.403089
GeneLoc Exon Structure
|
Expression
for LCE6A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LCE6A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTATTAGTA
About this image
See LCE6A Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.62927
SABiosciences Custom PCR Arrays for LCE6A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LCE6A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LCE6A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LCE6A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCE6A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCE6A |
Orthologs
for LCE6A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for LCE6A gene from 1/2 species (see all 2) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Lce6a5 |
late cornified envelope 6A |
-- |
|
3 (40.14 cM) 92620081 |
ENSEMBL Gene Tree for LCE6A (if available)
TreeFam Gene Tree for LCE6A (if available) |
Paralogs
for LCE6A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for LCE6A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LCE6A (152815330 - 152816459 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LCE6A
1 CNV: 3314 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LCE6A |
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Disorders
/ Diseases
for LCE6A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for LCE6A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LCE6A gene integrated from 9 sources:
(articles sorted by number of sources associating them with LCE6A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large-scale identification of human genes implicated in epidermal barrier function. (PubMed id 17562024)2 Toulza E.... Guerrin M. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Late cornified envelope family in differentiating epithelia -- response to calcium and ultraviolet irradiation. (PubMed id 15854049)1 Jackson B.... Byrne C. (2005)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
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External Searches for LCE6A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing LCE6A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LCE6A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LCE6A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LCE6A | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for LCE6A gene:
Search GeneIP for patents involving LCE6A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LCE6A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LCE6A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LCE6A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LCE6A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LCE6A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCE6A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCE6A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LCE6A | | OriGene Custom Protein Services for LCE6A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LCE6A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LCE6A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCE6A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LCE6A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCE6A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LCE6A |
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 |  |  |  | |
| | | | Search Tocris compounds for LCE6A |
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 | | | LCE6A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LCE6A |
|  |  |  | | | | Search ThermoFisher Antibodies for LCE6A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LCE6A |
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