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Aliases for LCE6A Gene

Aliases for LCE6A Gene

  • Late Cornified Envelope 6A 2 3
  • C1orf44 3 4
  • Chromosome 1 Open Reading Frame 44 2
  • Late Cornified Envelope Protein 6A 3

External Ids for LCE6A Gene

Previous HGNC Symbols for LCE6A Gene

  • C1orf44

Previous GeneCards Identifiers for LCE6A Gene

  • GC01U901418
  • GC01P151082
  • GC01P152815
  • GC01P124178

Summaries for LCE6A Gene

GeneCards Summary for LCE6A Gene

LCE6A (Late Cornified Envelope 6A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LCE6A Gene

  • Precursors of the cornified envelope of the stratum corneum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCE6A Gene

Genomics for LCE6A Gene

Regulatory Elements for LCE6A Gene

Genomic Location for LCE6A Gene

Start:
152,842,854 bp from pter
End:
152,843,983 bp from pter
Size:
1,130 bases
Orientation:
Plus strand

Genomic View for LCE6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LCE6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE6A Gene

Proteins for LCE6A Gene

  • Protein details for LCE6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A183-LCE6A_HUMAN
    Recommended name:
    Late cornified envelope protein 6A
    Protein Accession:
    A0A183
    Secondary Accessions:

    Protein attributes for LCE6A Gene

    Size:
    80 amino acids
    Molecular mass:
    9022 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Belongs to the LCE cluster present on 1q21

neXtProt entry for LCE6A Gene

Proteomics data for LCE6A Gene at MOPED

Post-translational modifications for LCE6A Gene

No Post-translational modifications

Other Protein References for LCE6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE6A Gene

Domains for LCE6A Gene

Gene Families for LCE6A Gene

HGNC:
  • LCE :Late cornified envelopes

Protein Domains for LCE6A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for LCE6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0A183

UniProtKB/Swiss-Prot:

LCE6A_HUMAN :
  • A0A183
Family:
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE6A: view

Function for LCE6A Gene

Molecular function for LCE6A Gene

UniProtKB/Swiss-Prot Function: Precursors of the cornified envelope of the stratum corneum.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LCE6A Gene

Localization for LCE6A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCE6A Gene COMPARTMENTS Subcellular localization image for LCE6A gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LCE6A Gene

Pathways for LCE6A Gene

SuperPathways for LCE6A Gene

No Data Available

Interacting Proteins for LCE6A Gene

Gene Ontology (GO) - Biological Process for LCE6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with LCE6A: view

No data available for Pathways by source for LCE6A Gene

Transcripts for LCE6A Gene

mRNA/cDNA for LCE6A Gene

(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCE6A Gene

Late cornified envelope 6A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LCE6A Gene

No ASD Table

Relevant External Links for LCE6A Gene

GeneLoc Exon Structure for
LCE6A
ECgene alternative splicing isoforms for
LCE6A

Expression for LCE6A Gene

mRNA expression in normal human tissues for LCE6A Gene

mRNA differential expression in normal tissues according to GTEx for LCE6A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (33.8) and Skin - Not Sun Exposed (Suprapubic) (18.8).

SOURCE GeneReport for Unigene cluster for LCE6A Gene Hs.62927

genes like me logo Genes that share expressions with LCE6A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for LCE6A Gene

Orthologs for LCE6A Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for LCE6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCE6A 35
  • 98.75 (n)
  • 96.25 (a)
LCE6A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lce6a 16
Species with no ortholog for LCE6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCE6A Gene

ENSEMBL:
Gene Tree for LCE6A (if available)
TreeFam:
Gene Tree for LCE6A (if available)

Paralogs for LCE6A Gene

No data available for Paralogs for LCE6A Gene

Variants for LCE6A Gene

Sequence variations from dbSNP and Humsavar for LCE6A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1411615 -- 152,844,406(+) AATTT(A/T)AAAAG downstream-variant-500B
rs1411618 -- 152,842,797(+) ATGAC(A/G)TGTGG upstream-variant-2KB
rs4378153 -- 152,841,186(+) TTCCT(A/G)CTAAT upstream-variant-2KB
rs6673420 -- 152,842,383(+) TGTGA(C/G)ATGTA upstream-variant-2KB
rs6684782 -- 152,840,946(+) TATTA(C/T)GGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LCE6A Gene

Variant ID Type Subtype PubMed ID
dgv131e1 CNV Complex 17122850
nsv831592 CNV Gain 17160897

Relevant External Links for LCE6A Gene

HapMap Linkage Disequilibrium report
LCE6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCE6A Gene

Disorders for LCE6A Gene

No disorders were found for LCE6A Gene.

No data available for UniProtKB/Swiss-Prot for LCE6A Gene

Publications for LCE6A Gene

  1. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3
  2. Late cornified envelope family in differentiating epithelia -- response to calcium and ultraviolet irradiation. (PMID: 15854049) Jackson B. … Byrne C. (J. Invest. Dermatol. 2005) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  4. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 4

Products for LCE6A Gene

Sources for LCE6A Gene

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