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Aliases for LCE6A Gene

Aliases for LCE6A Gene

  • Late Cornified Envelope 6A 2 3 5
  • C1orf44 3 4
  • Chromosome 1 Open Reading Frame 44 2
  • Late Cornified Envelope Protein 6A 3

External Ids for LCE6A Gene

Previous HGNC Symbols for LCE6A Gene

  • C1orf44

Previous GeneCards Identifiers for LCE6A Gene

  • GC01U901418
  • GC01P151082
  • GC01P152815
  • GC01P124178

Summaries for LCE6A Gene

GeneCards Summary for LCE6A Gene

LCE6A (Late Cornified Envelope 6A) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.

UniProtKB/Swiss-Prot for LCE6A Gene

  • Precursors of the cornified envelope of the stratum corneum.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCE6A Gene

Genomics for LCE6A Gene

Regulatory Elements for LCE6A Gene

Enhancers for LCE6A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G152855 0.2 ENCODE 0.4 +13.0 13006 0.2 LOC105371444 LCE6A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LCE6A on UCSC Golden Path with GeneCards custom track

Genomic Location for LCE6A Gene

Chromosome:
1
Start:
152,842,854 bp from pter
End:
152,843,983 bp from pter
Size:
1,130 bases
Orientation:
Plus strand

Genomic View for LCE6A Gene

Genes around LCE6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE6A Gene

Proteins for LCE6A Gene

  • Protein details for LCE6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A183-LCE6A_HUMAN
    Recommended name:
    Late cornified envelope protein 6A
    Protein Accession:
    A0A183

    Protein attributes for LCE6A Gene

    Size:
    80 amino acids
    Molecular mass:
    9022 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE6A Gene

Post-translational modifications for LCE6A Gene

No Post-translational modifications

Other Protein References for LCE6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE6A Gene

Domains & Families for LCE6A Gene

Gene Families for LCE6A Gene

Protein Domains for LCE6A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LCE6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0A183

UniProtKB/Swiss-Prot:

LCE6A_HUMAN :
  • Belongs to the LCE family.
Family:
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE6A: view

Function for LCE6A Gene

Molecular function for LCE6A Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.

Phenotypes for LCE6A Gene

GenomeRNAi human phenotypes for LCE6A:
genes like me logo Genes that share phenotypes with LCE6A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE6A Gene

Localization for LCE6A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCE6A gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LCE6A Gene

Pathways & Interactions for LCE6A Gene

genes like me logo Genes that share pathways with LCE6A: view

Pathways by source for LCE6A Gene

Interacting Proteins for LCE6A Gene

Gene Ontology (GO) - Biological Process for LCE6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with LCE6A: view

No data available for SIGNOR curated interactions for LCE6A Gene

Transcripts for LCE6A Gene

mRNA/cDNA for LCE6A Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCE6A Gene

Late cornified envelope 6A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCE6A Gene

No ASD Table

Relevant External Links for LCE6A Gene

GeneLoc Exon Structure for
LCE6A
ECgene alternative splicing isoforms for
LCE6A

Expression for LCE6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCE6A Gene

mRNA differential expression in normal tissues according to GTEx for LCE6A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x33.8) and Skin - Not Sun Exposed (Suprapubic) (x18.8).

NURSA nuclear receptor signaling pathways regulating expression of LCE6A Gene:

LCE6A

SOURCE GeneReport for Unigene cluster for LCE6A Gene:

Hs.62927

Evidence on tissue expression from TISSUES for LCE6A Gene

  • Skin(4.4)
genes like me logo Genes that share expression patterns with LCE6A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCE6A Gene

Orthologs for LCE6A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LCE6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCE6A 34 35
  • 98.75 (n)
Species where no ortholog for LCE6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCE6A Gene

ENSEMBL:
Gene Tree for LCE6A (if available)
TreeFam:
Gene Tree for LCE6A (if available)

Paralogs for LCE6A Gene

No data available for Paralogs for LCE6A Gene

Variants for LCE6A Gene

Sequence variations from dbSNP and Humsavar for LCE6A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000002818 -- 152,844,240(+) TACAG(A/T)TGTAA downstream-variant-500B
rs1000815254 -- 152,841,660(+) TTGCT(C/T)ATCTT upstream-variant-2KB
rs1001167274 -- 152,840,911(+) AAAAG(A/G)AGGGG upstream-variant-2KB
rs1002229306 -- 152,842,229(+) ATTCA(A/G)CAAAT upstream-variant-2KB
rs1002433596 -- 152,842,503(+) GGAGT(A/T)GACAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LCE6A Gene

Variant ID Type Subtype PubMed ID
dgv432n100 CNV gain 25217958
esv2758970 CNV gain+loss 17122850
esv2761937 CNV gain 21179565
esv3587570 CNV gain 21293372
nsv1008447 CNV gain 25217958
nsv1010576 CNV loss 25217958
nsv547899 CNV gain 21841781
nsv831592 CNV gain 17160897

Variation tolerance for LCE6A Gene

Gene Damage Index Score: 2.18; 39.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCE6A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LCE6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCE6A Gene

Disorders for LCE6A Gene

Relevant External Links for LCE6A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCE6A

No disorders were found for LCE6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE6A Gene

Publications for LCE6A Gene

  1. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  3. Late cornified envelope family in differentiating epithelia -- response to calcium and ultraviolet irradiation. (PMID: 15854049) Jackson B. … Byrne C. (J. Invest. Dermatol. 2005) 3 64
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3 64

Products for LCE6A Gene

Sources for LCE6A Gene

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