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Aliases for LCE3E Gene

Aliases for LCE3E Gene

  • Late Cornified Envelope 3E 2 3 5
  • Late Envelope Protein 17 3 4
  • LEP17 3 4

External Ids for LCE3E Gene

Previous GeneCards Identifiers for LCE3E Gene

  • GC01M149351
  • GC01M150804
  • GC01M123911

Summaries for LCE3E Gene

GeneCards Summary for LCE3E Gene

LCE3E (Late Cornified Envelope 3E) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LCE3E Gene

  • Precursors of the cornified envelope of the stratum corneum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCE3E Gene

Genomics for LCE3E Gene

Regulatory Elements for LCE3E Gene

Enhancers for LCE3E Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LCE3E on UCSC Golden Path with GeneCards custom track

Genomic Location for LCE3E Gene

152,565,654 bp from pter
152,566,772 bp from pter
1,119 bases
Minus strand

Genomic View for LCE3E Gene

Genes around LCE3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE3E Gene

Proteins for LCE3E Gene

  • Protein details for LCE3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Late cornified envelope protein 3E
    Protein Accession:
    Secondary Accessions:
    • A2RRM6

    Protein attributes for LCE3E Gene

    92 amino acids
    Molecular mass:
    9507 Da
    Quaternary structure:
    No Data Available
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE3E Gene

Proteomics data for LCE3E Gene at MOPED

Post-translational modifications for LCE3E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCE3E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE3E Gene

Domains & Families for LCE3E Gene

Gene Families for LCE3E Gene

Protein Domains for LCE3E Gene


Suggested Antigen Peptide Sequences for LCE3E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LCE family.
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE3E: view

Function for LCE3E Gene

Molecular function for LCE3E Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.
UniProtKB/Swiss-Prot Induction:

Gene Ontology (GO) - Molecular Function for LCE3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
genes like me logo Genes that share ontologies with LCE3E: view

Phenotypes for LCE3E Gene

genes like me logo Genes that share phenotypes with LCE3E: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE3E Gene

Localization for LCE3E Gene

Subcellular locations from

Jensen Localization Image for LCE3E Gene COMPARTMENTS Subcellular localization image for LCE3E gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LCE3E Gene

Pathways & Interactions for LCE3E Gene

SuperPathways for LCE3E Gene

No Data Available

Gene Ontology (GO) - Biological Process for LCE3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA --
GO:0018149 peptide cross-linking IBA --
genes like me logo Genes that share ontologies with LCE3E: view

No data available for Pathways by source and SIGNOR curated interactions for LCE3E Gene

Drugs & Compounds for LCE3E Gene

No Compound Related Data Available

Transcripts for LCE3E Gene

mRNA/cDNA for LCE3E Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCE3E Gene

Late cornified envelope 3E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LCE3E Gene

No ASD Table

Relevant External Links for LCE3E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LCE3E Gene

mRNA expression in normal human tissues for LCE3E Gene

mRNA differential expression in normal tissues according to GTEx for LCE3E Gene

This gene is overexpressed in Cervix - Ectocervix (x26.6) and Vagina (x15.9).

SOURCE GeneReport for Unigene cluster for LCE3E Gene Hs.490208

mRNA Expression by UniProt/SwissProt for LCE3E Gene

Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
genes like me logo Genes that share expression patterns with LCE3E: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LCE3E Gene

Orthologs for LCE3E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LCE3E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LCE3E 36
  • 97 (a)
Species with no ortholog for LCE3E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCE3E Gene

Gene Tree for LCE3E (if available)
Gene Tree for LCE3E (if available)

Paralogs for LCE3E Gene

No data available for Paralogs for LCE3E Gene

Variants for LCE3E Gene

Sequence variations from dbSNP and Humsavar for LCE3E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7416330 -- 152,568,046(+) tattt(C/T)tttaa upstream-variant-2KB
rs7417224 -- 152,565,813(+) AGCTC(A/T)GCCTG utr-variant-3-prime
rs10888501 -- 152,565,478(+) CCTGT(A/G)TCGTT downstream-variant-500B
rs17659359 -- 152,565,882(+) CTTGG(C/G)ATTCT utr-variant-3-prime
rs17659389 -- 152,566,917(+) CCTGT(A/G)TACTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LCE3E Gene

Variant ID Type Subtype PubMed ID
esv2750810 CNV Gain 17911159
dgv129e1 CNV Complex 17122850
dgv130e1 CNV Complex 17122850
dgv131e1 CNV Complex 17122850
dgv37n27 CNV Loss 19166990
dgv38n27 CNV Loss 19166990
dgv39n27 CNV Loss 19166990
nsv470739 CNV Loss 18288195
nsv516961 CNV Loss 19592680
nsv872446 CNV Loss 21882294
nsv2888 CNV Loss 18451855
nsv437244 CNV Loss 16327808

Variation tolerance for LCE3E Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LCE3E Gene

Disorders for LCE3E Gene

Relevant External Links for LCE3E

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LCE3E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE3E Gene

Publications for LCE3E Gene

  1. Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. (PMID: 19721433) McClay J.L. … van den Oord E.J. (Mol. Psychiatry 2011) 3 48 67
  2. Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D. … Byrne C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N. … Mountain J. (PLoS Genet. 2010) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for LCE3E Gene

Sources for LCE3E Gene