LCE3E Gene
protein-coding GIFtS: 35
GCID: GC01M152538
|
|
late cornified envelope 3E
| |
Aliases
for LCE3E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Late Cornified Envelope 3E1 2 | | LEP171 2 3 5 | | Late Envelope Protein 172 3 | | Late Cornified Envelope Protein 3E2 |
Export aliases for LCE3E gene to outside databasesPrevious GC identifers: GC01M149351 GC01M150804 GC01M123911 |
Summaries
for LCE3E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LCE3E_HUMAN, Q5T5B0Function: Precursors of the cornified envelope of the stratum corneum
|
Genomic Views
for LCE3E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LCE3E gene promoter:
GR Spz1 C/EBPbeta AML1a GR-beta GR-alpha PPAR-gamma2 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for LCE3E
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCE3E |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3LCE3E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M152538: view genomic region
(about GC identifiers)
Start:
|
152,538,130 bp from pter |
End:
|
152,539,248 bp from pter |
Size:
|
1,119 bases |
Orientation:
|
minus strand |
|
Proteins
for LCE3E gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LCE3E_HUMAN, Q5T5B0 (See
protein sequence)Recommended Name: Late cornified envelope protein 3E Size: 92 amino acids; 9507 Da
Miscellaneous: Belongs to the LCE cluster present on 1q21
Secondary accessions: A2RRM6Explore the universe of human proteins at neXtProt for LCE3E: NX_Q5T5B0
LCE3E Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848522.1
ENSEMBL proteins: ENSP00000357778
Human Recombinant Protein Products:
LCE3E Antibody Products:
Assay Products for LCE3E: |
Protein
Domains /
Families
for LCE3E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LCE3E for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T5B0ProtoNet protein and cluster: Q5T5B0 UniProtKB/Swiss-Prot: LCE3E_HUMAN, Q5T5B0Similarity: Belongs to the LCE family |
Function
for LCE3E gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LCE3E_HUMAN, Q5T5B0Function: Precursors of the cornified envelope of the stratum corneumInduction: By UVB
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCE3E
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCE3E
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LCE3E (NM_178435) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LCE3E | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCE3E |
|
Pathways & Interactions
for LCE3E gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LCE3E
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031424 | keratinization |
IEA | -- |
LCE3E for ontologies About GeneDecksing
|
Drugs & Compounds
for LCE3E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LCE3E
Search CenterWatch for drugs/clinical trials and news about LCE3E
|
Transcripts
for LCE3E gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LCE3E gene: NM_178435.3 Unigene Cluster for LCE3E: Late cornified envelope 3E Hs.490208 [show with all ESTs]Unigene Representative Sequence: NM_1784351 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000368789(uc001faa.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCE3E
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCE3E
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LCE3E (NM_178435) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LCE3E | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCE3E |
Additional cDNA sequence: BC131716.1 1 DOTS entry: DT.70104905 1 AceView cDNA sequence: NM_178435
GeneLoc Exon Structure
|
Expression
for LCE3E gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LCE3E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTCCCATA
About this image
See LCE3E Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.490208
UniProtKB/Swiss-Prot: LCE3E_HUMAN, Q5T5B0Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin,penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta
SABiosciences Custom PCR Arrays for LCE3E
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LCE3E
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LCE3E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LCE3E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCE3E |
Orthologs
for LCE3E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for LCE3E (if available)
TreeFam Gene Tree for LCE3E (if available) |
Paralogs
for LCE3E gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LCE3E gene
- LCE2B2 LCE2C2 LCE3C2 LCE3D2 LCE5A2 LCE1B2 LCE4A2 LCE3A2
- LCE1A2 LCE1E2 LCE2A2 LCE1D2 LCE1C2 CRCT12 LCE1F2 LCE3B2
- LCE2D2
LCE3E for paralogs About GeneDecksing
|
Genomic Variants
for LCE3E gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LCE3E (152538130 - 152539248 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for LCE3E
8 CNVs: 53453 3314 53646 48136 8333 48135 29836 53887 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LCE3E |
|
Disorders
/ Diseases
for LCE3E gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 LCE3E for disorders About MalaCards
LCE3E for disorders About GeneDecksing
OMIM gene information: 612617
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: LCE3E (1 document)
Export disorders for LCE3E gene to outside databases
|
Publications
for LCE3E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LCE3E gene integrated from 9 sources:
(articles sorted by number of sources associating them with LCE3E) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Late cornified envelope family in differentiating epithelia -- response to calcium and ultraviolet irradiation. (PubMed id 15854049)1, 2 Jackson B.... Byrne C. (2005)
- Differentially expressed late constituents of the epidermal cornified envelope. (PubMed id 11698679)1, 3 Marshall D....Byrne C. (2001)
- Web-based, participant-driven studies yield novel gen etic associations for common traits. (PubMed id 20585627)1 Eriksson N....Mountain J. (2010)
- Genome-wide pharmacogenomic analysis of response to t reatment with antipsychotics. (PubMed id 19721433)1 McClay J.L....van den Oord E.J. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for LCE3E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LCE3E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LCE3E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LCE3E gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LCE3E | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LCE3E gene:
Search GeneIP for patents involving LCE3E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LCE3E gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LCE3E | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LCE3E | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LCE3E | | | OriGene Protein Over-expression Lysate for LCE3E | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LCE3E | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCE3E | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCE3E | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LCE3E | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LCE3E | | OriGene Custom Protein Services for LCE3E | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LCE3E | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LCE3E | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCE3E | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LCE3E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCE3E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LCE3E |
| |
 |  |  |  | |
| | | | Search Tocris compounds for LCE3E |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | LCE3E Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for LCE3E |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCE3E |
|
|
|
|
