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Aliases for LCE3B Gene

Aliases for LCE3B Gene

  • Late Cornified Envelope 3B 2 3 5
  • Late Envelope Protein 14 3 4
  • LEP14 3 4
  • Late Cornified Envelope Protein 3B 3

External Ids for LCE3B Gene

Previous GeneCards Identifiers for LCE3B Gene

  • GC01P149400
  • GC01P150852
  • GC01P152586
  • GC01P123959

Summaries for LCE3B Gene

GeneCards Summary for LCE3B Gene

LCE3B (Late Cornified Envelope 3B) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.

UniProtKB/Swiss-Prot for LCE3B Gene

  • Precursors of the cornified envelope of the stratum corneum.

Additional gene information for LCE3B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCE3B Gene

Genomics for LCE3B Gene

Regulatory Elements for LCE3B Gene

Enhancers for LCE3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H152622 0.8 Ensembl ENCODE 0.4 +9.0 8967 1.1 CTCF POLR2A NRF1 MYC GABPA LCE1D PGLYRP4 LCE3A LCE3B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LCE3B on UCSC Golden Path with GeneCards custom track

Genomic Locations for LCE3B Gene

Genomic Locations for LCE3B Gene
288 bases
Plus strand

Genomic View for LCE3B Gene

Genes around LCE3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE3B Gene

Proteins for LCE3B Gene

  • Protein details for LCE3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Late cornified envelope protein 3B
    Protein Accession:

    Protein attributes for LCE3B Gene

    95 amino acids
    Molecular mass:
    9812 Da
    Quaternary structure:
    No Data Available
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE3B Gene

Post-translational modifications for LCE3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCE3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE3B Gene

Domains & Families for LCE3B Gene

Gene Families for LCE3B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LCE3B Gene


Suggested Antigen Peptide Sequences for LCE3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LCE family.
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE3B: view

Function for LCE3B Gene

Molecular function for LCE3B Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.

Phenotypes From GWAS Catalog for LCE3B Gene

Gene Ontology (GO) - Molecular Function for LCE3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
genes like me logo Genes that share ontologies with LCE3B: view

Phenotypes for LCE3B Gene

genes like me logo Genes that share phenotypes with LCE3B: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE3B Gene

Localization for LCE3B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LCE3B gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for LCE3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with LCE3B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for LCE3B Gene

Pathways & Interactions for LCE3B Gene

genes like me logo Genes that share pathways with LCE3B: view

Pathways by source for LCE3B Gene

Gene Ontology (GO) - Biological Process for LCE3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA --
GO:0018149 peptide cross-linking IBA --
GO:0030216 keratinocyte differentiation IBA --
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with LCE3B: view

No data available for SIGNOR curated interactions for LCE3B Gene

Drugs & Compounds for LCE3B Gene

No Compound Related Data Available

Transcripts for LCE3B Gene

mRNA/cDNA for LCE3B Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LCE3B Gene

No ASD Table

Relevant External Links for LCE3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LCE3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LCE3B Gene

Protein differential expression in normal tissues from HIPED for LCE3B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LCE3B Gene

Protein tissue co-expression partners for LCE3B Gene

NURSA nuclear receptor signaling pathways regulating expression of LCE3B Gene:


SOURCE GeneReport for Unigene cluster for LCE3B Gene:


mRNA Expression by UniProt/SwissProt for LCE3B Gene:

Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
genes like me logo Genes that share expression patterns with LCE3B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LCE3B Gene

Orthologs for LCE3B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LCE3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LCE3B 34
  • 96 (a)
Species where no ortholog for LCE3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCE3B Gene

Gene Tree for LCE3B (if available)
Gene Tree for LCE3B (if available)

Paralogs for LCE3B Gene

No data available for Paralogs for LCE3B Gene

Variants for LCE3B Gene

Sequence variations from dbSNP and Humsavar for LCE3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000235638 -- 152,614,467(+) GAAAA(A/C/T)TAAAC downstream-variant-500B
rs1006211884 -- 152,612,744(+) CATGC(C/T)CCTGG upstream-variant-2KB
rs1014213738 -- 152,614,458(+) TTGTG(A/G)CTGGA downstream-variant-500B
rs1017599399 -- 152,612,499(+) TGGGC(A/C)AATTG upstream-variant-2KB
rs1021907556 -- 152,613,784(+) TTTAT(C/G)TATCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LCE3B Gene

Variant ID Type Subtype PubMed ID
nsv947446 CNV deletion 23825009
nsv8402 CNV gain+loss 18304495
nsv821155 CNV deletion 20802225
nsv68 CNV deletion 15895083
nsv547891 CNV loss 21841781
nsv547862 CNV loss 21841781
nsv510990 OTHER complex 20534489
nsv498689 CNV loss 21111241
nsv469873 CNV loss 16826518
nsv441941 CNV loss 18776908
nsv2888 CNV deletion 18451855
nsv1078961 CNV deletion 25765185
nsv1002425 CNV loss 25217958
nsv1000122 CNV gain+loss 25217958
esv998954 CNV deletion 20482838
esv3587563 CNV loss 21293372
esv3540812 CNV deletion 23714750
esv33483 CNV gain+loss 17666407
esv2974901 CNV deletion 24192839
esv2764248 CNV gain+loss 21179565
esv2762965 CNV loss 21179565
esv2758970 CNV gain+loss 17122850
esv2750810 CNV gain 17911159
esv2718195 CNV deletion 23290073
esv2615503 CNV loss 19546169
esv25112 CNV gain+loss 19812545
esv2421966 CNV deletion 20811451
dgv8n73 CNV deletion 24416366
dgv76n67 CNV loss 20364138
dgv71e199 CNV deletion 23128226
dgv6e213 CNV loss 24956385
dgv5e213 CNV gain 24956385
dgv574n54 CNV gain 21841781
dgv573n54 CNV gain 21841781
dgv571n54 CNV loss 21841781
dgv570n54 CNV gain+loss 21841781
dgv568n54 CNV loss 21841781
dgv4n50 CNV loss 21212237
dgv428n100 CNV gain 25217958
dgv427n100 CNV gain 25217958
dgv426n100 CNV loss 25217958
dgv425n100 CNV gain 25217958
dgv423n100 CNV gain 25217958
dgv420n100 CNV gain+loss 25217958
dgv418n100 CNV loss 25217958
dgv417n100 CNV gain 25217958
dgv39n27 CNV loss 19166990
dgv2n31 CNV loss 19718026
dgv23n111 CNV deletion 26073780
dgv21n16 CNV deletion 17901297
dgv201n106 CNV deletion 24896259
dgv100e212 CNV loss 25503493

Variation tolerance for LCE3B Gene

Gene Damage Index Score: 1.21; 24.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCE3B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCE3B Gene

Disorders for LCE3B Gene

Relevant External Links for LCE3B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LCE3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE3B Gene

Publications for LCE3B Gene

  1. Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors. (PMID: 20016497) Hüffmeier U … Reis A (The Journal of investigative dermatology 2010) 3 45 60
  2. Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis. (PMID: 20213803) Docampo E … Estivill X (Arthritis and rheumatism 2010) 3 45 60
  3. Mutation analysis of the LCE3B/LCE3C genes in Psoriasis. (PMID: 20331852) Coto E … Alvarez V (BMC medical genetics 2010) 3 45 60
  4. Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis. (PMID: 20376060) Bergboer JG … Schalkwijk J (The Journal of investigative dermatology 2010) 3 45 60
  5. LCE3C_LCE3B-del genotype and psoriasis: a summative meta-analysis. (PMID: 20624365) Wiwanitkit V (Acta dermatovenerologica Croatica : ADC 2010) 3 45 60

Products for LCE3B Gene

Sources for LCE3B Gene

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