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Aliases for LCE3B Gene

Aliases for LCE3B Gene

  • Late Cornified Envelope 3B 2 3 5
  • Late Envelope Protein 14 3 4
  • LEP14 3 4

External Ids for LCE3B Gene

Previous GeneCards Identifiers for LCE3B Gene

  • GC01P149400
  • GC01P150852
  • GC01P123959

Summaries for LCE3B Gene

GeneCards Summary for LCE3B Gene

LCE3B (Late Cornified Envelope 3B) is a Protein Coding gene. An important paralog of this gene is LCE3C.

UniProtKB/Swiss-Prot for LCE3B Gene

  • Precursors of the cornified envelope of the stratum corneum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCE3B Gene

Genomics for LCE3B Gene

Regulatory Elements for LCE3B Gene

Enhancers for LCE3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LCE3B on UCSC Golden Path with GeneCards custom track

Genomic Location for LCE3B Gene

152,613,811 bp from pter
152,614,098 bp from pter
288 bases
Plus strand

Genomic View for LCE3B Gene

Genes around LCE3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE3B Gene

Proteins for LCE3B Gene

  • Protein details for LCE3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Late cornified envelope protein 3B
    Protein Accession:

    Protein attributes for LCE3B Gene

    95 amino acids
    Molecular mass:
    9812 Da
    Quaternary structure:
    No Data Available
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE3B Gene

Proteomics data for LCE3B Gene at MOPED

Post-translational modifications for LCE3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCE3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE3B Gene

Domains & Families for LCE3B Gene

Gene Families for LCE3B Gene

Protein Domains for LCE3B Gene


Suggested Antigen Peptide Sequences for LCE3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LCE family.
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE3B: view

Function for LCE3B Gene

Molecular function for LCE3B Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.

Phenotypes for LCE3B Gene

GenomeRNAi human phenotypes for LCE3B:
genes like me logo Genes that share phenotypes with LCE3B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE3B Gene

Localization for LCE3B Gene

Subcellular locations from

Jensen Localization Image for LCE3B Gene COMPARTMENTS Subcellular localization image for LCE3B gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LCE3B Gene

Pathways & Interactions for LCE3B Gene

SuperPathways for LCE3B Gene

No Data Available

Interacting Proteins for LCE3B Gene

Gene Ontology (GO) - Biological Process for LCE3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA --
GO:0018149 peptide cross-linking IBA --
genes like me logo Genes that share ontologies with LCE3B: view

No data available for Pathways by source and SIGNOR curated interactions for LCE3B Gene

Drugs & Compounds for LCE3B Gene

No Compound Related Data Available

Transcripts for LCE3B Gene

mRNA/cDNA for LCE3B Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for LCE3B Gene

No ASD Table

Relevant External Links for LCE3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LCE3B Gene

mRNA expression in normal human tissues for LCE3B Gene

Protein differential expression in normal tissues from HIPED for LCE3B Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LCE3B Gene

SOURCE GeneReport for Unigene cluster for LCE3B Gene Hs.553715

mRNA Expression by UniProt/SwissProt for LCE3B Gene

Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
genes like me logo Genes that share expression patterns with LCE3B: view

Protein tissue co-expression partners for LCE3B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LCE3B Gene

Orthologs for LCE3B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LCE3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LCE3B 36
  • 96 (a)
Species with no ortholog for LCE3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCE3B Gene

Gene Tree for LCE3B (if available)
Gene Tree for LCE3B (if available)

Paralogs for LCE3B Gene

Paralogs for LCE3B Gene

genes like me logo Genes that share paralogs with LCE3B: view

Variants for LCE3B Gene

Sequence variations from dbSNP and Humsavar for LCE3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11205041 -- 152,613,589(+) AGACA(C/T)CAGCA upstream-variant-2KB
rs12061193 -- 152,612,540(+) ATCTC(A/G)ACTAT upstream-variant-2KB
rs12076556 -- 152,612,696(+) ATCAC(A/C)CAACA upstream-variant-2KB
rs12065120 -- 152,614,174(+) ACTTG(A/T)TAGAT downstream-variant-500B
rs56122637 -- 152,612,766(+) AGGAA(A/T)AGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LCE3B Gene

Variant ID Type Subtype PubMed ID
esv2750810 CNV Gain 17911159
dgv129e1 CNV Complex 17122850
dgv130e1 CNV Complex 17122850
dgv131e1 CNV Complex 17122850
dgv39n27 CNV Loss 19166990
nsv872446 CNV Loss 21882294
nsv2888 CNV Loss 18451855
nsv68 CNV Loss 15895083
esv33483 CNV Gain+Loss 17666407
dgv389n71 CNV Gain 21882294
dgv2n31 CNV Deletion 19718026
esv2615503 CNV Loss 19546169
esv998954 CNV Deletion 20482838
dgv21n16 CNV Deletion 17901297
nsv8402 CNV Gain+Loss 18304495
nsv510990 CNV Complex 20534489
esv2421966 CNV Deletion 20811451
dgv4n50 CNV Loss 21212237
esv2718195 CNV Deletion 23290073
dgv76n67 CNV Loss 20364138
nsv821155 CNV Deletion 20802225
nsv498689 CNV Loss 21111241
dgv71e199 CNV Deletion 23128226
esv25112 CNV Gain+Loss 19812545
nsv441941 CNV CNV 18776908
nsv469873 CNV Complex 16826518
nsv872449 CNV Gain 21882294

Variation tolerance for LCE3B Gene

Gene Damage Index Score: 1.21; 24.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCE3B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCE3B Gene

Disorders for LCE3B Gene

Relevant External Links for LCE3B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LCE3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE3B Gene

Publications for LCE3B Gene

  1. Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis. (PMID: 20376060) Bergboer J.G. … Schalkwijk J. (J. Invest. Dermatol. 2010) 3 48 67
  2. Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D. … Byrne C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families. (PMID: 24485035) Ammar M. … Marrakchi R. (Pathol. Biol. 2014) 3
  4. Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients. (PMID: 24566688) Chiraz B.S. … Slaheddine S. (Mol. Biol. Rep. 2014) 3
  5. Association between the LCE3C_LCE3B deletion polymorphism and susceptibility to psoriasis: a meta-analysis of published studies. (PMID: 23631431) Song G.G. … Lee Y.H. (Genet Test Mol Biomarkers 2013) 3

Products for LCE3B Gene

Sources for LCE3B Gene