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Aliases for LCE2A Gene

Aliases for LCE2A Gene

  • Late Cornified Envelope 2A 2 3 5
  • Late Envelope Protein 9 3 4
  • LEP9 3 4

External Ids for LCE2A Gene

Previous GeneCards Identifiers for LCE2A Gene

  • GC01P149484
  • GC01P150937
  • GC01P124044

Summaries for LCE2A Gene

GeneCards Summary for LCE2A Gene

LCE2A (Late Cornified Envelope 2A) is a Protein Coding gene. An important paralog of this gene is LCE2D.

UniProtKB/Swiss-Prot for LCE2A Gene

  • Precursors of the cornified envelope of the stratum corneum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LCE2A Gene

Genomics for LCE2A Gene

Regulatory Elements for LCE2A Gene


Genomic Location for LCE2A Gene

Chromosome:
1
Start:
152,698,364 bp from pter
End:
152,699,442 bp from pter
Size:
1,079 bases
Orientation:
Plus strand

Genomic View for LCE2A Gene

Genes around LCE2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LCE2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LCE2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LCE2A Gene

Proteins for LCE2A Gene

  • Protein details for LCE2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TA79-LCE2A_HUMAN
    Recommended name:
    Late cornified envelope protein 2A
    Protein Accession:
    Q5TA79
    Secondary Accessions:
    • A4QMZ9

    Protein attributes for LCE2A Gene

    Size:
    106 amino acids
    Molecular mass:
    10846 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Belongs to the LCE cluster present on 1q21.

neXtProt entry for LCE2A Gene

Proteomics data for LCE2A Gene at MOPED

Post-translational modifications for LCE2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LCE2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LCE2A Gene

Domains & Families for LCE2A Gene

Gene Families for LCE2A Gene

Protein Domains for LCE2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LCE2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TA79

UniProtKB/Swiss-Prot:

LCE2A_HUMAN :
  • Belongs to the LCE family.
Family:
  • Belongs to the LCE family.
genes like me logo Genes that share domains with LCE2A: view

Function for LCE2A Gene

Molecular function for LCE2A Gene

UniProtKB/Swiss-Prot Function:
Precursors of the cornified envelope of the stratum corneum.
UniProtKB/Swiss-Prot Induction:
By calcium and UVB.

Gene Ontology (GO) - Molecular Function for LCE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
genes like me logo Genes that share ontologies with LCE2A: view
genes like me logo Genes that share phenotypes with LCE2A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LCE2A Gene

Localization for LCE2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LCE2A Gene COMPARTMENTS Subcellular localization image for LCE2A gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LCE2A Gene

Pathways & Interactions for LCE2A Gene

SuperPathways for LCE2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for LCE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA --
GO:0018149 peptide cross-linking IBA --
genes like me logo Genes that share ontologies with LCE2A: view

No data available for Pathways by source and SIGNOR curated interactions for LCE2A Gene

Drugs & Compounds for LCE2A Gene

(1) Drugs for LCE2A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with LCE2A: view

Transcripts for LCE2A Gene

mRNA/cDNA for LCE2A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LCE2A Gene

Late cornified envelope 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LCE2A Gene

No ASD Table

Relevant External Links for LCE2A Gene

GeneLoc Exon Structure for
LCE2A
ECgene alternative splicing isoforms for
LCE2A

Expression for LCE2A Gene

mRNA expression in normal human tissues for LCE2A Gene

mRNA differential expression in normal tissues according to GTEx for LCE2A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x34.4) and Skin - Not Sun Exposed (Suprapubic) (x17.9).

SOURCE GeneReport for Unigene cluster for LCE2A Gene Hs.334054

mRNA Expression by UniProt/SwissProt for LCE2A Gene

Q5TA79-LCE2A_HUMAN
Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
genes like me logo Genes that share expression patterns with LCE2A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LCE2A Gene

Orthologs for LCE2A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LCE2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LCE2A 36
  • 99 (a)
OneToOne
Species with no ortholog for LCE2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LCE2A Gene

ENSEMBL:
Gene Tree for LCE2A (if available)
TreeFam:
Gene Tree for LCE2A (if available)

Paralogs for LCE2A Gene

Paralogs for LCE2A Gene

genes like me logo Genes that share paralogs with LCE2A: view

Variants for LCE2A Gene

Sequence variations from dbSNP and Humsavar for LCE2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs58733562 - 152,698,960(+) AAAAT(A/G)CCCAC reference, missense
rs3898602 -- 152,696,489(+) GCTGT(A/G)AGCCT upstream-variant-2KB
rs3908717 -- 152,699,437(+) CTCTT(C/G)GTGAA utr-variant-3-prime
rs4845317 -- 152,697,865(+) ACAGC(A/G)ACATG upstream-variant-2KB
rs7413401 -- 152,696,891(+) TTGTG(A/G)ATTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LCE2A Gene

Variant ID Type Subtype PubMed ID
dgv130e1 CNV Complex 17122850
dgv131e1 CNV Complex 17122850
esv33483 CNV Gain+Loss 17666407
nsv469873 CNV Complex 16826518
nsv509480 CNV Insertion 20534489
esv34854 CNV Gain 17911159

Variation tolerance for LCE2A Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LCE2A Gene

HapMap Linkage Disequilibrium report
LCE2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LCE2A Gene

Disorders for LCE2A Gene

Relevant External Links for LCE2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LCE2A

No disorders were found for LCE2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LCE2A Gene

Publications for LCE2A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Differentially expressed late constituents of the epidermal cornified envelope. (PMID: 11698679) Marshall D. … Byrne C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Late cornified envelope family in differentiating epithelia -- response to calcium and ultraviolet irradiation. (PMID: 15854049) Jackson B. … Byrne C. (J. Invest. Dermatol. 2005) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LCE2A Gene

Sources for LCE2A Gene

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