LCE1D Gene
protein-coding GIFtS: 32
GCID: GC01P152769
|
|
late cornified envelope 1D
| |
Aliases
for LCE1D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Late Cornified Envelope 1D1 2 | | LEP41 2 3 5 | | Late Envelope Protein 42 3 | | Late Cornified Envelope Protein 1D2 |
Export aliases for LCE1D gene to outside databasesPrevious GC identifers: GC01P149583 GC01P151035 |
Summaries
for LCE1D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LCE1D_HUMAN, Q5T752Function: Precursors of the cornified envelope of the stratum corneum
|
Genomic Views
for LCE1D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LCE1D gene promoter:
p53 AML1a POU3F1 Pax-2a HEN1 Pax-2b ZID ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for LCE1D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCE1D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3LCE1D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P152769: view genomic region
(about GC identifiers)
Start:
|
152,769,227 bp from pter |
End:
|
152,770,657 bp from pter |
Size:
|
1,431 bases |
Orientation:
|
plus strand |
|
Proteins
for LCE1D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LCE1D_HUMAN, Q5T752 (See
protein sequence)Recommended Name: Late cornified envelope protein 1D Size: 114 amino acids; 11230 Da
Miscellaneous: Belongs to the LCE cluster present on 1q21Explore the universe of human proteins at neXtProt for LCE1D: NX_Q5T752
LCE1D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848129.1
ENSEMBL proteins: ENSP00000316737
Human Recombinant Protein Products for LCE1D:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
LCE1D for ontologies About GeneDecksing
LCE1D Antibody Products:
Assay Products for LCE1D: |
Protein
Domains /
Families
for LCE1D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LCE1D for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T752ProtoNet protein and cluster: Q5T752 UniProtKB/Swiss-Prot: LCE1D_HUMAN, Q5T752Similarity: Belongs to the LCE family |
Function
for LCE1D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: LCE1D_HUMAN, Q5T752Function: Precursors of the cornified envelope of the stratum corneumInduction: By UVBAnimal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCE1D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCE1D
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LCE1D (NM_178352) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LCE1D | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCE1D |
|
Pathways & Interactions
for LCE1D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LCE1D
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
LCE1D for ontologies About GeneDecksing
|
Drugs & Compounds
for LCE1D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LCE1D
Search CenterWatch for drugs/clinical trials and news about LCE1D
|
Transcripts
for LCE1D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LCE1D gene: NM_178352.2 Unigene Cluster for LCE1D: Late cornified envelope 1D Hs.490235 Unigene Representative Sequence: NM_1783521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000326233(uc009wnp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCE1D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCE1D
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LCE1D (NM_178352) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LCE1D | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCE1D |
1 DOTS entry: DT.121337449 2 AceView cDNA sequences: BG697954 NM_178352
GeneLoc Exon Structure
|
Expression
for LCE1D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LCE1D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LCE1D Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.490235
UniProtKB/Swiss-Prot: LCE1D_HUMAN, Q5T752Tissue specificity: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin,penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta
SABiosciences Custom PCR Arrays for LCE1D
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LCE1D
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LCE1D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LCE1D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCE1D |
Orthologs
for LCE1D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for LCE1D (if available)
TreeFam Gene Tree for LCE1D (if available) |
Paralogs
for LCE1D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LCE1D gene
- LCE2B2 LCE3C2 LCE2C2 LCE3D2 LCE5A2 LCE3E2 LCE1B2 LCE4A2
- LCE3A2 LCE1A2 LCE1E2 LCE2A2 LCE1C2 CRCT12 LCE1F2 LCE3B2
- LCE2D2
LCE1D for paralogs About GeneDecksing
|
Genomic Variants
for LCE1D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LCE1D (152769227 - 152770657 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for LCE1D
14 CNVs: 30440 37401 97512 0394 3314 84579 23205 1559 64978 6786 31664 84578 34716 34715 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LCE1D |
|
Disorders
/ Diseases
for LCE1D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 LCE1D for disorders About MalaCards
LCE1D for disorders About GeneDecksing
OMIM gene information: 612606
OMIM disorders: --
Export disorders for LCE1D gene to outside databases
|
Publications
for LCE1D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LCE1D gene integrated from 9 sources:
(articles sorted by number of sources associating them with LCE1D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Late cornified envelope family in differentiating epithelia -- response to calcium and ultraviolet irradiation. (PubMed id 15854049)1, 2 Jackson B.... Byrne C. (2005)
- Differentially expressed late constituents of the epidermal cornified envelope. (PubMed id 11698679)1, 3 Marshall D....Byrne C. (2001)
|
External Searches for LCE1D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LCE1D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LCE1D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LCE1D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LCE1D | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LCE1D gene:
Search GeneIP for patents involving LCE1D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LCE1D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LCE1D | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LCE1D | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LCE1D | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LCE1D | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LCE1D | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LCE1D | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LCE1D | | OriGene Custom Protein Services for LCE1D | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LCE1D | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LCE1D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LCE1D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LCE1D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LCE1D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LCE1D |
| |
 |  |  |  | |
| | | | Search Tocris compounds for LCE1D |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | LCE1D Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for LCE1D |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LCE1D |
| |  | |
|
|
|
