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LBXCOR1 Gene

protein-coding   GIFtS: 44

GC15P065906
LBXCOR1 homolog (mouse)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for LBXCOR1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CORL1 1, 2, 3
FUSSEL15 1, 2, 3
Fussel-15 3
Descriptions
Functional Smad-suppressing element on chromosome 15 3
LBX1 corepressor 1 3
LBXCOR1 homolog 2
LBXCOR1 homolog (mouse) 2
functional smad suppressing element 15 2
transcriptional corepressor CORL1 2
External Ids
HGNC: 213261
Entrez Gene: 3905982
UniProtKB: P845503
Ensembl: ENSG000001887797
Search outside databases for aliases for LBXCOR1 gene

Summaries
for LBXCOR1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LBXCO_HUMAN, P84550
Function: Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling

Genomic Location
for LBXCOR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LBXCOR1 gene  

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q23

LBXCOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P065906:     (about GC identifiers)

Start:
 65,899,096 bp from pter
End:
 65,913,228 bp from pter
Size:
 14,133 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  

Proteins
for LBXCOR1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: LBXCO_HUMAN, P84550 (See protein sequence)
Recommended Name: Ladybird homeobox corepressor 1  
Size: 965 amino acids; 99831 Da
Subunit: Interacts with LBX1 (By similarity). Interacts with SMAD1, SMAD2 and SMAD3
Subcellular location: Nucleus (By similarity)
Secondary accessions: A6NIP4 Q2VWA5
Alternative splicing: 2 isoforms:  P84550-1   P84550-2   

REFSEQ proteins: NP_001026977.1  

ENSEMBL proteins: 
ENSP00000369374 ENSP00000373654 ENSP00000343200 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (LBX1 corepressor 1 )
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
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Antibodies for LBXCOR1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (LBX1 corepressor 1 ), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for LBXCOR1

Assays for LBXCOR1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for LBXCOR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro domains/families:
 IPR010919 SAND-like
 IPR003380 Transform_Ski
 IPR014890 c-SKI_SMAD_bd


   GeneDecks  LBXCOR1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P84550

ProtoNet protein and cluster: P84550

2 Blocks protein families:
IPB000770 SAND domain
IPB010919 SAND-like


UniProtKB/Swiss-Prot: LBXCO_HUMAN, P84550
Similarity: Belongs to the SKI family

Gene Function
for LBXCOR1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (LBXCOR1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001031807

              Applied Biosystems Silencer® siRNAs for LBXCOR1

              Sigma-Aldrich siRNA for LBXCOR1  
                     Sigma-Aldrich shRNA for LBXCOR1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001031807
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001031807
                                 untagged cDNA clone in CMV expression vector: NM_001031807 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001031807

UniProtKB/Swiss-Prot: LBXCO_HUMAN, P84550
Function: Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0005515 protein binding IEA--
About this table

Pathways & Interactions
for LBXCOR1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/6 Interacting proteins for LBXCOR1 (ENSP000003693743) via UniProtKB, MINT, and/or STRING (see all 6 )
InteractantInteraction Details
GeneCardExternal ID(s)
LBX1ENSP000003592123STRING (score=.962)
BTBD9ENSP000003234083STRING (score=.902)
SMAD3ENSP000003329733STRING (score=.899)
SMAD2ENSP000002621603STRING (score=.898)
MAP2K5ENSP000003464933STRING (score=.878)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table

Drugs & Compounds
for LBXCOR1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LBXCOR1

Transcripts
for LBXCOR1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (LBXCOR1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001031807

              Sigma-Aldrich siRNA for LBXCOR1  
                     Sigma-Aldrich shRNA for LBXCOR1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001031807  

REFSEQ mRNAs for LBXCOR1 gene: 

NM_001031807.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001031807  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001031807
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001031807
                                 untagged cDNA clone in CMV expression vector: NM_001031807 

Additional cDNA sequence: AY669507.1 

2 DOTS entries:

DT.101970423  DT.40311326 

2 AceView cDNA sequences:

CF136193 BI831656 

highest scoring ESTs for LBXCOR1:

AY669507 BE791947 CF136193 AI028393 BF111237 BF432767 BF509358 BF511948 BG056966 BI831656 

Unigene Cluster for LBXCOR1:

LBXCOR1 homolog (mouse)
Hs.451224  [show with all ESTs]
Unigene Representative Sequence: NM_001031807


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000380035  ENST00000389002  ENST00000341418  

Expression
for LBXCOR1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LBXCOR1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for LBXCOR1

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: TTCTGGCCAG

SOURCE GeneReport for Unigene cluster: Hs.451224

UniProtKB/Swiss-Prot: LBXCO_HUMAN, P84550
Tissue specificity: Present specifically in cerebellar Purkinje cells (at protein level)

Orthologs
for LBXCOR1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for LBXCOR1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LBXCOR11   -- LBXCOR1 homolog (mouse) 93.27(n)
96.21(a)		 610933  XM_848522.1  XP_853615.1 
chimpanzee
(Pan troglodytes)		 LBXCOR11   -- LBXCOR1 homolog (mouse) 99.1(n)
98.99(a)		 453533  XM_510499.2  XP_510499.2 
rat
(Rattus norvegicus)		 Lbxcor11   -- LBXCOR1 homolog (mouse) 87.46(n)
93.24(a)		 315748  XM_236329.4  XP_236329.4 
mouse
(Mus musculus)		 Lbxcor11, 5 95
 ladybird homeobox 1 homolog (Drosophila) corepressor more1, 5 87.69(n)1
93.03(a)1		 2076671  NM_172446.21  NP_766034.11 
 AB1851135  AK0299165  (see all 9)
zebrafish
(Danio rerio)		 LOC1000076171   -- similar to Ladybird homeobox corepressor 1 64.21(n)
65.39(a)		 100007617  XM_001345995.2  XP_001346031.2 
About this table        Species with no ortholog for LBXCOR1

ENSEMBL Gene Tree for LBXCOR1

Paralogs
for LBXCOR1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for LBXCOR1 gene
ENSG000002154742  SKI2  SKIL2  

SNPs/Variants
for LBXCOR1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/35 NCBI SNPs in LBXCOR1 are shown (see all 35 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 48)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 15 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs71701851,2
A,C65904354(+) AGAAGA/TGGATC 1 -- ng510--------
rs47769871,2
A,C,F,H65910969(+) ATCTAT/ACCCTC 1 -- int14Minor allele frequency- A:0.40EU EA WA 418
rs47769881,2
C,F,H65911205(+) AATTGT/CAGGCA 1 -- int18Minor allele frequency- C:0.23EU EA WA 836
rs71831681,2
A,C65908537(+) GCGCCA/CCCCTA 1 -- int10--------
rs47769851,2
A,C65910075(+) TGGATG/TCCTGT 1 -- int10--------
rs9224941,2
F65907698(+) GAAACT/CGGGCC 1 -- int11Minor allele frequency- C:0.16MN 184
rs47769861,2
C65910584(+) GTAACA/GATGAT 1 -- int10--------
rs47769841,2
A65905248(+) CTCGGA/CGCGCC 1 -- int10--------
rs286752951,2
--65903454(+) TCGGGA/CGCTGT 1 -- ng510--------
--
rs49947431,2
--65906574(+) cagggG/Tcgggc 1 A/S mis1 ese30--------
About this table

HapMap Linkage Disequilibrium images for LBXCOR1 (up to first 250kb)

Disorders & Mutations
for LBXCOR1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 611273

Human Genome Epidemiology Navigator: LBXCOR1 (2 documents)

Medical News
for LBXCOR1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for LBXCOR1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

6 PubMed articles for LBXCOR1 gene:

Search for LBXCOR1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing LBXCOR1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 390598 HGNC: 21326 AceView: LOC390598 Ensembl:ENSG00000188779 euGenes: HUgn390598
ECgene: LBXCOR1 H-InvDB: LBXCOR1

Other Databases showing LBXCOR1

(According to HUGE)
About This Section

   --

Specialized Databases showing LBXCOR1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for LBXCOR1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for LBXCOR1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for LBXCOR1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LBXCOR1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for LBXCOR1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for LBXCOR1 Browse small molecules at Sigma-Aldrich
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 Search OriGene for LBXCOR1
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 Search Novus for antibodies for LBXCOR1

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