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Aliases for LBX2 Gene

Aliases for LBX2 Gene

  • Ladybird Homeobox 2 2 3 5
  • Ladybird Homeobox Protein Homolog 2 3 4
  • Ladybird Homeobox Homolog 2 (Drosophila) 2
  • Ladybird-Like Homeodomain Protein 2 3
  • Ladybird Homeobox Homolog 2 3
  • Lady Bird-Like Homeobox 2 3
  • Transcription Factor LBX2 3
  • Ladybird-Like Homeobox 2 3
  • LP3727 3

External Ids for LBX2 Gene

Previous GeneCards Identifiers for LBX2 Gene

  • GC02U990293
  • GC02M074637
  • GC02M074578
  • GC02M074724
  • GC02M074460

Summaries for LBX2 Gene

GeneCards Summary for LBX2 Gene

LBX2 (Ladybird Homeobox 2) is a Protein Coding gene. Diseases associated with LBX2 include Alstrom Syndrome. An important paralog of this gene is LBX1.

UniProtKB/Swiss-Prot for LBX2 Gene

  • Putative transcription factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LBX2 Gene

Genomics for LBX2 Gene

Regulatory Elements for LBX2 Gene

Enhancers for LBX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F074528 0.2 ENCODE 31.7 -27.0 -27010 4.4 HDGF ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 LBX2 WBP1 CCDC142 PCGF1 DUSP11 ENSG00000270571 MOGS MTHFD2 ENSG00000273245 TTC31
GH02F074496 1.2 ENCODE 27.5 +2.6 2581 8.5 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS PAF1 LBX2 ENSG00000272183 AUP1 GC02P074500
GH02F074513 1.1 Ensembl ENCODE 25.2 -11.9 -11917 3.0 PKNOX1 ATF1 MLX ARID4B SIN3A FOS DEK NFYC ZHX2 REST LBX2 WBP1 PCGF1 ALMS1P1 MRPL53 CCDC142 C2orf81 TLX2 DQX1
GH02F074487 0.2 ENCODE 23.2 +13.0 12978 4.9 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 LBX2 HTRA2 AUP1 DQX1 MOGS TLX2 WBP1 DOK1 LOXL3 GC02P074500
GH02F074480 0.2 ENCODE 23.1 +20.9 20896 3.0 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ENSG00000270571 LBX2 PCGF1 MTHFD2 WBP1 DUSP11 ENSG00000273245 TTC31 MRPL53
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LBX2 on UCSC Golden Path with GeneCards custom track

Promoters for LBX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001653943 216 1801 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 JUNB

Genomic Location for LBX2 Gene

Chromosome:
2
Start:
74,497,517 bp from pter
End:
74,503,316 bp from pter
Size:
5,800 bases
Orientation:
Minus strand

Genomic View for LBX2 Gene

Genes around LBX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LBX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LBX2 Gene

Proteins for LBX2 Gene

  • Protein details for LBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XYB7-LBX2_HUMAN
    Recommended name:
    Transcription factor LBX2
    Protein Accession:
    Q6XYB7
    Secondary Accessions:
    • Q7Z5Y8

    Protein attributes for LBX2 Gene

    Size:
    198 amino acids
    Molecular mass:
    21482 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LBX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LBX2 Gene

Post-translational modifications for LBX2 Gene

No Post-translational modifications

Other Protein References for LBX2 Gene

No data available for DME Specific Peptides for LBX2 Gene

Domains & Families for LBX2 Gene

Gene Families for LBX2 Gene

Protein Domains for LBX2 Gene

Suggested Antigen Peptide Sequences for LBX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6XYB7

UniProtKB/Swiss-Prot:

LBX2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with LBX2: view

Function for LBX2 Gene

Molecular function for LBX2 Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Gene Ontology (GO) - Molecular Function for LBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with LBX2: view
genes like me logo Genes that share phenotypes with LBX2: view

Animal Models for LBX2 Gene

MGI Knock Outs for LBX2:

Animal Model Products

miRNA for LBX2 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LBX2 Gene

Localization for LBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LBX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LBX2 Gene COMPARTMENTS Subcellular localization image for LBX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for LBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LBX2: view

Pathways & Interactions for LBX2 Gene

SuperPathways for LBX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with LBX2: view

No data available for Pathways by source and SIGNOR curated interactions for LBX2 Gene

Transcripts for LBX2 Gene

mRNA/cDNA for LBX2 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LBX2 Gene

Ladybird homeobox 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LBX2 Gene

No ASD Table

Relevant External Links for LBX2 Gene

GeneLoc Exon Structure for
LBX2
ECgene alternative splicing isoforms for
LBX2

Expression for LBX2 Gene

mRNA expression in normal human tissues for LBX2 Gene

mRNA differential expression in normal tissues according to GTEx for LBX2 Gene

This gene is overexpressed in Liver (x11.5).

Protein differential expression in normal tissues from HIPED for LBX2 Gene

This gene is overexpressed in Platelet (43.5) and Heart (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LBX2 Gene



Protein tissue co-expression partners for LBX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LBX2 Gene:

LBX2

SOURCE GeneReport for Unigene cluster for LBX2 Gene:

Hs.516124
genes like me logo Genes that share expression patterns with LBX2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LBX2 Gene

Orthologs for LBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LBX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LBX2 34 35
  • 99.16 (n)
cow
(Bos Taurus)
Mammalia LBX2 34 35
  • 84.52 (n)
dog
(Canis familiaris)
Mammalia LBX2 34 35
  • 83.94 (n)
mouse
(Mus musculus)
Mammalia Lbx2 34 16 35
  • 79.58 (n)
rat
(Rattus norvegicus)
Mammalia Lbx2 34
  • 78.12 (n)
oppossum
(Monodelphis domestica)
Mammalia LBX2 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lbx2 35
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta lbl 35
  • 15 (a)
ManyToMany
lbe 35
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
Species where no ortholog for LBX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LBX2 Gene

ENSEMBL:
Gene Tree for LBX2 (if available)
TreeFam:
Gene Tree for LBX2 (if available)

Paralogs for LBX2 Gene

(1) SIMAP similar genes for LBX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LBX2: view

Variants for LBX2 Gene

Sequence variations from dbSNP and Humsavar for LBX2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10454145 -- 74,498,677(+) GACAT(C/T)AGAGG intron-variant
rs1060782 -- 74,504,612(+) CCACT(A/C)CATTT intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs113126054 -- 74,499,560(+) CGGTC(C/G)GGCTG intron-variant, upstream-variant-2KB
rs113362902 -- 74,502,242(+) CCTAC(C/G)CCCAC intron-variant, upstream-variant-2KB
rs114058045 -- 74,499,369(+) TCCGC(A/G)GAAAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LBX2 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781
nsv582215 CNV loss 21841781

Variation tolerance for LBX2 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.32; 85.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LBX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LBX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LBX2 Gene

Disorders for LBX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LBX2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
alstrom syndrome
  • alström syndrome
- elite association - COSMIC cancer census association via MalaCards
Search LBX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LBX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LBX2
genes like me logo Genes that share disorders with LBX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LBX2 Gene

Publications for LBX2 Gene

  1. Characterization of the murine Lbx2 promoter, identification of the human homologue, and evaluation as a candidate for Alstrom syndrome. (PMID: 11386758) Chen F. … Epstein J.A. (Genomics 2001) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3 64

Products for LBX2 Gene

Sources for LBX2 Gene

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