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LBX2 Gene

protein-coding GIFtS: 44

GC02M074578

ladybird homeobox 2
(Previous name: ladybird homeobox homolog 2 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
LP3727 ^²

Descriptions
Ladybird homeobox protein homolog 2 ^³
lady bird-like homeobox 2 ^²
ladybird homeobox 2 ^²
ladybird homeobox homolog 2 ^²
ladybird homeobox homolog 2 (Drosophila) ^¹
ladybird-like homeobox 2 ^²
ladybird-like homeodomain protein 2 ^²

External Ids
HGNC: 15525¹
Entrez Gene: 85474²
UniProtKB: Q6XYB7³
Ensembl: ENSG00000179528⁷

Search outside databases for aliases for LBX2 gene

Previous GC identifers: GC02U990293 GC02M074637

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LBX2_HUMAN, Q6XYB7

Function: Putative transcription factor (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LBX2 gene

Entrez Gene cytogenetic band: 2p13.1 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13.1

LBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M074578: (about GC identifiers)

Start:	74,578,152 bp from pter
End:	74,583,951 bp from pter
Size:	5,800 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LBX2_HUMAN, Q6XYB7 (See protein sequence)

Recommended Name: Transcription factor LBX2

Size: 198 amino acids; 21482 Da

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q7Z5Y8

Alternative splicing: 2 isoforms: Q6XYB7-1 Q6XYB7-2

REFSEQ proteins: NP_001009812.1

ENSEMBL proteins:

ENSP00000366789 ENSP00000340709

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Lbx2)
	Human Recombinant Proteins from Abnova (LBX2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for LBX2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of LBX2
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Lbx2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LBX2)
	Novus Biologicals Antibody for LBX2

Assays for LBX2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q6XYB7

ProtoNet protein and cluster: Q6XYB7

1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: LBX2_HUMAN, Q6XYB7

Similarity: Contains 1 homeobox DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LBX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LBX2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001009812

Applied Biosystems Silencer® siRNAs for LBX2

Sigma-Aldrich siRNA for LBX2

Sigma-Aldrich shRNA for LBX2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001009812
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001009812
untagged cDNA clone in CMV expression vector: NM_001009812

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001009812

UniProtKB/Swiss-Prot: LBX2_HUMAN, Q6XYB7

Function: Putative transcription factor (By similarity)

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lbx2):

homeostasis/metabolism

lethality-prenatal/perinatal

life span-post-weaning/aging

nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LBX2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LBX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LBX2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001009812

Sigma-Aldrich siRNA for LBX2

Sigma-Aldrich shRNA for LBX2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001009812

REFSEQ mRNAs for LBX2 gene:

NM_001009812.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001009812

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001009812
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001009812
                                 untagged cDNA clone in CMV expression vector: NM_001009812

Additional cDNA sequence:

AY203953.1 AY305861.1 BC127932.1 BC127933.1 BC144442.1 BC150517.1 BC150518.1

3 DOTS entries:

DT.91754253 DT.101959191 DT.99982153

highest scoring ESTs for LBX2:

AA037704 AY305861 BG752934 DA370843 DA379250 DA383994 DA385128 DA385387 DA640774 DA642591

Unigene Cluster for LBX2:

Ladybird homeobox 2

Hs.516124 [show with all ESTs]

Unigene Representative Sequence: AY305861

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000377566 ENST00000341396

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LBX2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LBX2

¹ Data from GNF BioGPS
About these images

About these images

CGAP SAGE TAG: GTCCCCCGAG

SOURCE GeneReport for Unigene cluster: Hs.516124

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LBX2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LBX2¹	--	ladybird homeobox 2	68.93(n) 63.28(a)	483103 XM_540219.2 XP_540219.2
chimpanzee (Pan troglodytes)	LBX2¹	--	ladybird homeobox 2	84.83(n) 81.44(a)	741363 XM_001143919.1 XP_001143919.1
cow (Bos taurus)	LBX2¹	--	ladybird homeobox 2	70.63(n) 68.11(a)	538906 XM_583559.3 XP_583559.3
rat (Rattus norvegicus)	Lbx2¹	--	ladybird homeobox 2	68.03(n) 67.25(a)	500224 XM_575575.2 XP_575575.2
mouse (Mus musculus)	Lbx2^{1, 5}	6 (35.00 cM)⁵	ladybird homeobox homolog 2 (Drosophila)^{1, 5}	68.67(n)¹ 71.08(a)¹	16815¹ NM_010692.3¹ NP_034822.1¹ AA017789⁵ AF146150⁵ (see all 7)

About this table Species with no ortholog for LBX2

ENSEMBL Gene Tree for LBX2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LBX2 gene

NKX3-2² LBX1² BSX² NKX3-1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/11 NCBI SNPs in LBX2 are shown (see all 11 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 31)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs17009998^1,2	C,F,H	74578686(+)	`CCGGGG/AACAAC`	1	F/S	mis¹ ese³		20		NA EU EA WA CA CSAM	1746
	rs6546908^1,2	C,F,H	74578652(+)	`GCGCCC/TTCGGG`	1	E/E	syn¹		8		EU EA WA	836
	rs10454145^1,2	C,F,H	74579312(+)	`GACATC/TAGAGG`	1	--	int¹		8		EU EA WA NA	628
	rs11688069^1,2	C,F,H	74580268(+)	`AGCCTC/TGGACC`	1	--	int¹ ese³		2		EU WA	210
	rs13414573^1,2	F,H	74579734(+)	`GTTGGC/AGACGG`	1	--	int¹		4		EU EA WA	412
	rs11688235^1,2	H	74580548(+)	`TCCGGC/GTCATA`	1	--	int¹		4		EU EA WA	418
	rs12473841^1,2	C	74580455(+)	`CTGCTC/TCGCGC`	1	--	int¹		0	--	--	--	--
--	rs34123935^1,2	--	74577944(+)	`TGAAG-/GCTGGC`	1	--	ng5¹		0	--	--	--	--
	rs61998167^1,2	--	74578721(+)	`CGCATC/GTCCTC`	1	E/D	mis¹		0	--	--	--	--
--	rs12105316^1,2	--	74578838(+)	`TACTTC/TTGGAA`	1	Q/Q	syn¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for LBX2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607164

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for LBX2 gene:

Characterization of the murine Lbx2 promoter, identification of the human homologue, and evaluation as a candidate for Alstrom syndrome. (PubMed id 11386758)^{2, 3, 4} Chen F.... Epstein J.A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)⁴ Wan D....Gu J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
Toward a complete human genome sequence. (PubMed id 9847074)³ (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 85474	HGNC: 15525	Ensembl:ENSG00000179528	euGenes: HUgn85474	ECgene: LBX2
H-InvDB: LBX2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LBX2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LBX2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LBX2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LBX2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LBX2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LBX2)
	Antibodies (LBX2)
	Chimera RNAi (LBX2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Lbx2)
	Antibodies (Lbx2)

Search OriGene for LBX2

Search Tocris compounds for LBX2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LBX2

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LBX2 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for LBX2

Summaries
for LBX2

Genomic Location
for LBX2

Proteins
for LBX2

Protein Domains/
Families
for LBX2

Gene Function
for LBX2

Pathways & Interactions
for LBX2

Drugs & Compounds
for LBX2

Transcripts
for LBX2

Expression
for LBX2

Orthologs
for LBX2

Paralogs
for LBX2

SNPs/Variants
for LBX2

Disorders & Mutations
for LBX2

Medical News
for LBX2

Publications
for LBX2

Search for LBX2

Genome Databases showing LBX2

Other Databases showing LBX2

Specialized Databases showing LBX2

Licensable Technologies
for LBX2

Services
for LBX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LBX2 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor LBX2

Summariesfor LBX2

Genomic Locationfor LBX2

Proteinsfor LBX2

Protein Domains/Familiesfor LBX2

Gene Functionfor LBX2

Pathways & Interactionsfor LBX2

Drugs & Compoundsfor LBX2

Transcriptsfor LBX2

Expression for LBX2

Orthologsfor LBX2

Paralogsfor LBX2

SNPs/Variantsfor LBX2

Disorders & Mutationsfor LBX2

Medical Newsfor LBX2

Publicationsfor LBX2

Search for LBX2

Genome Databases showing LBX2

Other Databases showing LBX2

Specialized Databases showing LBX2

Licensable Technologiesfor LBX2

Servicesfor LBX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LBX2

Summaries
for LBX2

Genomic Location
for LBX2

Proteins
for LBX2

Protein Domains/
Families
for LBX2

Gene Function
for LBX2

Pathways & Interactions
for LBX2

Drugs & Compounds
for LBX2

Transcripts
for LBX2

Expression
for LBX2

Orthologs
for LBX2

Paralogs
for LBX2

SNPs/Variants
for LBX2

Disorders & Mutations
for LBX2

Medical News
for LBX2

Publications
for LBX2

Licensable Technologies
for LBX2

Services
for LBX2