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Aliases for LBX2 Gene

Aliases for LBX2 Gene

  • Ladybird Homeobox 2 2 3
  • Ladybird Homeobox Protein Homolog 2 3 4
  • Ladybird Homeobox Homolog 2 (Drosophila) 2
  • Ladybird-Like Homeodomain Protein 2 3
  • Ladybird Homeobox Homolog 2 3
  • Lady Bird-Like Homeobox 2 3
  • Transcription Factor LBX2 3
  • Ladybird-Like Homeobox 2 3
  • LP3727 3

External Ids for LBX2 Gene

Summaries for LBX2 Gene

GeneCards Summary for LBX2 Gene

LBX2 (Ladybird Homeobox 2) is a Protein Coding gene. Diseases associated with LBX2 include alstrom syndrome. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for LBX2 Gene

  • Putative transcription factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LBX2 Gene

Genomics for LBX2 Gene

Genomic Location for LBX2 Gene

Start:
74,497,517 bp from pter
End:
74,503,316 bp from pter
Size:
5,800 bases
Orientation:
Minus strand

Genomic View for LBX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LBX2 Gene

Regulatory Elements for LBX2 Gene

Proteins for LBX2 Gene

  • Protein details for LBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XYB7-LBX2_HUMAN
    Recommended name:
    Transcription factor LBX2
    Protein Accession:
    Q6XYB7
    Secondary Accessions:
    • Q7Z5Y8

    Protein attributes for LBX2 Gene

    Size:
    198 amino acids
    Molecular mass:
    21482 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LBX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LBX2 Gene

Proteomics data for LBX2 Gene at MOPED

Post-translational modifications for LBX2 Gene

No Post-translational modifications

Other Protein References for LBX2 Gene

No data available for DME Specific Peptides for LBX2 Gene

Domains for LBX2 Gene

Gene Families for LBX2 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for LBX2 Gene

UniProtKB/Swiss-Prot:

LBX2_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q6XYB7
genes like me logo Genes that share domains with LBX2: view

Function for LBX2 Gene

Molecular function for LBX2 Gene

UniProtKB/Swiss-Prot Function: Putative transcription factor.

Gene Ontology (GO) - Molecular Function for LBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with LBX2: view
genes like me logo Genes that share phenotypes with LBX2: view

Animal Models for LBX2 Gene

MGI Knock Outs for LBX2:

miRNA for LBX2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LBX2 Gene

Localization for LBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LBX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LBX2 Gene COMPARTMENTS Subcellular localization image for LBX2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for LBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LBX2: view

Pathways for LBX2 Gene

SuperPathways for LBX2 Gene

No Data Available

Interacting Proteins for LBX2 Gene

Gene Ontology (GO) - Biological Process for LBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with LBX2: view

No data available for Pathways by source for LBX2 Gene

Transcripts for LBX2 Gene

mRNA/cDNA for LBX2 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LBX2 Gene

Ladybird homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LBX2 Gene

No ASD Table

Relevant External Links for LBX2 Gene

GeneLoc Exon Structure for
LBX2
ECgene alternative splicing isoforms for
LBX2

Expression for LBX2 Gene

mRNA expression in normal human tissues for LBX2 Gene

mRNA differential expression in normal tissues according to GTEx for LBX2 Gene

This gene is overexpressed in Liver (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LBX2 Gene

SOURCE GeneReport for Unigene cluster for LBX2 Gene Hs.516124

genes like me logo Genes that share expressions with LBX2: view

Orthologs for LBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LBX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LBX2 36
  • 99.16 (n)
  • 98.48 (a)
LBX2 37
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LBX2 36
  • 84.52 (n)
  • 80.1 (a)
LBX2 37
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LBX2 36
  • 83.94 (n)
  • 80.63 (a)
LBX2 37
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lbx2 36
  • 79.58 (n)
  • 81.15 (a)
Lbx2 16
Lbx2 37
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LBX2 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lbx2 36
  • 78.12 (n)
  • 77.44 (a)
zebrafish
(Danio rerio)
Actinopterygii lbx2 37
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta lbe 37
  • 13 (a)
ManyToMany
lbl 37
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToMany
Species with no ortholog for LBX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LBX2 Gene

ENSEMBL:
Gene Tree for LBX2 (if available)
TreeFam:
Gene Tree for LBX2 (if available)

Paralogs for LBX2 Gene

Selected SIMAP similar genes for LBX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LBX2: view

Variants for LBX2 Gene

Sequence variations from dbSNP and Humsavar for LBX2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6546908 -- 74,498,017(+) GCGCC(C/T)TCGGG reference, synonymous-codon
rs10454145 -- 74,498,677(+) GACAT(C/T)AGAGG intron-variant
rs11688069 -- 74,499,633(+) AGCCT(C/T)GGACC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs11688235 -- 74,499,913(+) TCCGG(C/G)TCATA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs12105316 -- 74,498,203(+) TACTT(C/T)TGGAA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for LBX2 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Relevant External Links for LBX2 Gene

HapMap Linkage Disequilibrium report
LBX2

Disorders for LBX2 Gene

(1) MalaCards Diseases for LBX2 Gene

Search for LBX2 Gene in MalaCards »
genes like me logo Genes that share disorders with LBX2: view

No data available for UniProtKB/Swiss-Prot for LBX2 Gene

Publications for LBX2 Gene

  1. Characterization of the murine Lbx2 promoter, identification of the human homologue, and evaluation as a candidate for Alstrom syndrome. (PMID: 11386758) Chen F. … Epstein J.A. (Genomics 2001) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 4
  5. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3

Products for LBX2 Gene

Sources for LBX2 Gene

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