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Aliases & Descriptions for LBX1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| HPX-6 2 | | HPX6 1, 2 | | LBX1H 1, 2, 3, 5 | | OTTHUMP00000180669 2 | | homeobox 2 |
| | | Descriptions |
|---|
| Ladybird homeobox protein homolog 1 3 | | lady bird-like homeobox 2 | | ladybird homeobox 1 2 | | ladybird homeobox homolog 1 2 | | ladybird homeobox homolog 1 (Drosophila) 1 | transcription factor similar to D. melanogaster homeodomain protein lady bird late 2 |
|
| | Search outside databases for aliases for LBX1 genePrevious GC identifers: GC10M101879 GC10M102220 GC10M103117 GC10M102651 |
Summaries for LBX1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LBX1: This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq] UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954Function: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord (By similarity)Gene Wiki entry for LBX1 |
Genomic Location for LBX1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LBX1 gene 
Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24.32LBX1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M102976:
(about GC identifiers)
Start:
|
102,976,723 bp from pter |
End:
|
102,978,707 bp from pter |
Size:
|
1,985 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for LBX1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954 (See
protein sequence)Recommended Name: Transcription factor LBX1 Size: 281 amino acids; 30221 Da
Subunit: Interacts with LBXCOR1 which acts as a transcriptional corepressor (By similarity)
Subcellular location: Nucleus (Probable)
Secondary accessions: Q05BB2REFSEQ proteins: NP_006553.2
ENSEMBL proteins: ENSP00000359212
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0005667 | transcription factor complex |
IEA | -- | About this table
Antibodies for LBX1: Assays for LBX1: | Protein
Domains/ Families for LBX1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P52954
ProtoNet protein and cluster: P52954 1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature
UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954Similarity: Contains 1 homeobox DNA-binding domain | Gene Function for LBX1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006562
Applied Biosystems Silencer® siRNAs for LBX1
Sigma-Aldrich siRNA for LBX1  Sigma-Aldrich shRNA for LBX1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006562                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006562                                  untagged cDNA clone in CMV expression vector: NM_006562 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006562
UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954Function: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord (By similarity)8 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Lbx1):
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | About this table | Pathways & Interactions for LBX1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/13 Interacting proteins for LBX1 (ENSP000003592123) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001947 | heart looping |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007399 | nervous system development |
IEA | -- | | GO:0007519 | skeletal muscle development |
IEA | -- | About this table
|
Drugs & Compounds for LBX1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LBX1 1 Novoseek chemical compound relationship for LBX1 gene
About this table
|
Transcripts for LBX1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006562
Sigma-Aldrich siRNA for LBX1  Sigma-Aldrich shRNA for LBX1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006562 REFSEQ mRNAs for LBX1 gene: NM_006562.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006562               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006562                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006562                                  untagged cDNA clone in CMV expression vector: NM_006562  Additional cDNA sequence: AJ004949.1 BC069156.1 BC136321.1 X74863.1 1 DOTS entry: DT.92414048 6 AceView cDNA sequences:X74863 BV197771 BC069156 X90828 NM_006562 AJ004949
highest scoring ESTs for LBX1:BC069156 NM_006562 X90828 AJ004949 X74863 Unigene Cluster for LBX1: Ladybird homeobox 1 Hs.37128 Unigene Representative Sequence: BC069156
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000370193
|
Expression for LBX1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LBX1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LBX1
1 / 2 / 3 3 probe-sets matching LBX1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.37128
Expression variation in blood from EXPOLDB for LBX1 |
Orthologs for LBX1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LBX1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for LBX1
ENSEMBL Gene Tree for LBX1 | Paralogs for LBX1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LBX1 gene
- NKX3-22 BSX2 LBX22 NKX3-12
|
SNPs/Variants for LBX1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LBX1 (up to first 250kb)
|
Disorders & Mutations for LBX1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604255
10/26 Novoseek disease relationships for LBX1 gene (see all 26
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemogenesis |
52.09 |
4 |
10905048 (2), 9292516 (1), 9885434 (1) |
| leukemia |
37.62 |
10 |
1358259 (1), 9592016 (1), 16525506 (1), 9292516 (1) (see all 9) |
| congenital malformation |
27.48 |
3 |
9274447 (1), 1351112 (1), 17062780 (1) |
| teratocarcinoma |
26.67 |
1 |
7622051 (1) |
| acute leukemia |
22.80 |
2 |
7680402 (1), 10905048 (1) |
| neoplastic transformation |
22.52 |
2 |
8105782 (1), 11889211 (1) |
| carcinoma embryonal |
15.84 |
2 |
1975088 (2) |
| cancer |
15.50 |
26 |
12360280 (3), 1977958 (3), 12908068 (3), 14667497 (2) (see all 15) |
| colon cancer |
15.11 |
1 |
12270759 (1) |
| cryptorchidism |
13.79 |
3 |
14960020 (2), 10037424 (1) |
About this table
|
Medical News for LBX1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LBX1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/144 PubMed articles for LBX1 gene (see all 144
): |
Search for LBX1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LBX1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LBX1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LBX1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LBX1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LBX1:

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| | Recombinant Proteins (LBX1) | | Antibodies (LBX1) |
| | | Search Tocris compounds for LBX1 |
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Incremental update: 13 Oct 2009
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