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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LBX1 Gene

protein-coding   GIFtS: 50
GCID: GC10M102976

ladybird homeobox 1

(Previous name: ladybird homeobox homolog 1 (Drosophila) )
 Explore 33 diseases affiliated with
LBX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LBX1    

Aliases
for LBX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ladybird Homeobox 11 2     Homeobox1
LBX1H1 2 3 5     Lady Bird-Like Homeobox2
HPX61 2     Ladybird Homeobox Homolog 12
Ladybird Homeobox Protein Homolog 12 3     Transcription Factor LBX12
Ladybird Homeobox Homolog 1 (Drosophila)1     Transcription Factor Similar To D. Melanogaster Homeodomain Protein Lady Bird
Late2
HPX-62     

External Ids:    HGNC: 169601   Entrez Gene: 106602   Ensembl: ENSG000001381367   OMIM: 6042555   UniProtKB: P529543   

Export aliases for LBX1 gene to outside databases

Previous GC identifers: GC10M101879 GC10M102220 GC10M103117 GC10M102651 GC10M096616


Summaries
for LBX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LBX1:
This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late
homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the
acquisition of dorsal identities of forelimb muscles. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
Function: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal
cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and
hypoglossal cord (By similarity)

Gene Wiki entry for LBX1


Genomic Views
for LBX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LBX1 gene promoter:
         COUP-TF1   Lmo2   COUP   Nkx2-5   HNF-4alpha2   HNF-4alpha1   COUP-TF   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LBX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LBX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LBX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.32

LBX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LBX1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M102976:  view genomic region     (about GC identifiers)

Start:
 102,986,733 bp from pter      End:
 102,989,551 bp from pter
Size:
 2,819 bases      Orientation:
 minus strand

Proteins
for LBX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954 (See protein sequence)
Recommended Name: Transcription factor LBX1  
Size: 281 amino acids; 30221 Da
Subunit: Interacts with SKOR1 which acts as a transcriptional corepressor (By similarity)
Subcellular location: Nucleus (Probable)
Secondary accessions: B9EGA2 Q05BB2

Explore the universe of human proteins at neXtProt for LBX1: NX_P52954

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52954

    • LBX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006553.2  
    ENSEMBL proteins: 
     ENSP00000359212  

    Human Recombinant Protein Products: 
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    Novus Biologicals LBX1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LBX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex IEA--


    LBX1 for ontologies           About GeneDecksing



    LBX1 Antibody Products: 
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    Uscn Antibodies for LBX1
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    Uscn ELISAs and CLIAs for LBX1

    Protein Domains /
    Families
    for LBX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LBX1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P52954

    ProtoNet protein and cluster: P52954

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for LBX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
    Function: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal
    cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and
    hypoglossal cord (By similarity)

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LBX1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LBX1 (see all 9):
    hsa-miR-92a hsa-miR-137 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-4267 hsa-miR-363 hsa-miR-3177-3p
    SwitchGear 3'UTR luciferase reporter plasmid: LBX1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LBX1 (see all 7)
    OriGene shRNA RFP: LBX1
    OriGene siRNA: LBX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LBX1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LBX1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LBX1 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LBX1 

    Cell Line
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    Search LifeMap BioReagents cell lines for LBX1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LBX1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----


    LBX1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for LBX1:
     Decreased circadian period len  Increased HPV18 LCR reporter a  Increased cell number in G1, s 

    Animal Models:
         10 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Lbx1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    LBX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LBX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LBX1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for LBX1 (P529543 ENSP000003592124) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKOR1P845503, ENSP000003736544I2D: score=1 STRING: ENSP00000373654
    AP5B1Q2VPB73I2D: score=1 
    CCNKO759093I2D: score=1 
    DGCR6LQ9BY273I2D: score=1 
    FXR2P511163I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001947heart looping IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007517muscle organ development IEA--
    GO:0008285negative regulation of cell proliferation IEA--


    LBX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LBX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LBX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LBX1
    2 Novoseek chemical compound relationships for LBX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 41 10 8104620 (3), 1975088 (2), 1976508 (1), 1683800 (1) (see all 6)
    oligonucleotide 7.72 4 8570656 (1), 8103988 (1), 10402242 (1)

    Search CenterWatch for drugs/clinical trials and news about LBX1 

    Transcripts
    for LBX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LBX1 gene: 
    NM_006562.4  

    Unigene Cluster for LBX1:

    Ladybird homeobox 1
    Hs.37128
    Unigene Representative Sequence: BC069156
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370193(uc001ksx.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LBX1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LBX1 (see all 9):
    hsa-miR-92a hsa-miR-137 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-4267 hsa-miR-363 hsa-miR-3177-3p
    SwitchGear 3'UTR luciferase reporter plasmid: LBX1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LBX1 (see all 7)
    OriGene shRNA RFP: LBX1
    OriGene siRNA: LBX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LBX1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LBX1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LBX1 (NM_006562)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LBX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LBX1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LBX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LBX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LBX1

    Additional cDNA sequence: 

    AJ004949.1 BC069156.1 BC136321.1 X74863.1 

    1 DOTS entry:

    DT.92414048 

    6 AceView cDNA sequences:

    X74863 BV197771 BC069156 NM_006562 X90828 AJ004949 

    GeneLoc Exon Structure


    Expression
    for LBX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LBX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LBX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    LimbHindlimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    SomiteCervical Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    SomiteLumbar Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    LimbForelimb Dorsal MusclesMyoblastsSkeletal Muscle
    LimbForelimb Ventral MusclesMyoblastsSkeletal Muscle
    LimbHindlimb Dorsal MuscleMyoblastsSkeletal Muscle
    LimbHindlimb Ventral MuscleMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LBX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LBX1

    SOURCE GeneReport for Unigene cluster: Hs.37128
        SABiosciences Expression via Pathway-Focused PCR Array including LBX1: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LBX1

    Orthologs
    for LBX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LBX1 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia LBX16
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL343239.1(554933-558601)
    zebrafish
    (Danio rerio)    		 Actinopterygii lbx1h2 lady bird-like homeobox 1 homolog, (Drosophila) 79.32(n)   64276  AJ295165.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta lbl3 regulation of transcription specific RNA
    polymerase more    		 75(a)   93E1   --


    ENSEMBL Gene Tree for LBX1 (if available)
    TreeFam Gene Tree for LBX1 (if available) 

    Paralogs
    for LBX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LBX1 gene
    NKX2-32  TLX12  HMX22  NKX3-22  NKX2-82  NKX2-62  NKX2-12  NKX2-52  
    NKX2-22  HMX32  NKX2-42  TLX32  HMX12  LBX22  TLX22  NKX3-12  
    5 SIMAP similar genes for LBX1 using alignment to 1 protein entry:     LBX1_HUMAN:
    HPX-6    HOXB1    HOXA4    HLX    LBX2

    LBX1 for paralogs           About GeneDecksing



    Genomic Variants
    for LBX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/70 NCBI SNPs in LBX1 are shown (see all 70)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs780300991,2
    		C,--96617703(+) GGCTTG/TTTGGA 2 K N mis10--------
    rs748611581,2
    		C,F,--96618302(+) NNNNCC/TTCTCT 1 -- us2k11Minor allele frequency- T:0.04NA 120
    rs354486151,2
    		C,--96618558(+) CCGAGC/ATGTTT 1 -- us2k12Minor allele frequency- A:0.03NA 122
    rs1887328161,2
    		--102986268(+) TCCCCC/TTGCAT 1 -- ds50010--------
    rs1473771431,2
    		--102986409(+) GGGGAA/GGAAAG 1 -- ds50010--------
    rs13223311,2
    		C,F,A,H,--102986589(-) GGGAGG/TGGCAG 1 -- ds500126Minor allele frequency- T:0.50EA NA NS WA CSA 2480
    rs1812401941,2
    		--102986793(+) CACGGC/GGAGGG 1 -- ut310--------
    rs1509187571,2
    		C,F,--102987025(+) GCGCCG/ACTCAA 1 -- ut311Minor allele frequency- A:0.01NA 3900
    rs1448707901,2
    		C,--102987097(+) GGTCCG/ATGAGC 2 /T /M mis11Minor allele frequency- A:0.00NA 3626
    rs2001553231,2
    		--102987159(+) CCTGGC/GGGGAG 2 P syn10--------

    HapMap Linkage Disequilibrium report for LBX1 (102986733 - 102989551 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LBX1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LBX1
    DNA2.0 Custom Variant and Variant Library Synthesis for LBX1

    Disorders / Diseases
    for LBX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LBX1 for disorders           About GeneDecksing

    OMIM gene information: 604255    OMIM disorders: --

    20/33 diseases for LBX1 (see all 33):    About MalaCards
    leri-weill dyschondrosteosis    short stature    metabolic disorders    adenoid cystic carcinoma
    esophageal squamous cell carcinoma    cryptorchidism    squamous cell carcinoma    teratocarcinoma
    hemangioma    adenoiditis    acute leukemia    brachydactyly
    scoliosis    embryonal carcinoma    ovarian cancer    carcinoma
    osteosarcoma    prostate cancer    breast cancer    endometrial cancer

    10/26 Novoseek disease relationships for LBX1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 50.8 4 10905048 (2), 9292516 (1), 9885434 (1)
    leukemia 37.7 10 1358259 (1), 9592016 (1), 16525506 (1), 9292516 (1) (see all 9)
    congenital malformation 25.8 3 9274447 (1), 1351112 (1), 17062780 (1)
    teratocarcinoma 25.7 1 7622051 (1)
    acute leukemia 21.3 2 7680402 (1), 10905048 (1)
    neoplastic transformation 21.1 2 8105782 (1), 11889211 (1)
    cancer 20.2 27 12360280 (3), 1977958 (3), 12908068 (3), 14667497 (2) (see all 15)
    carcinoma embryonal 14.6 2 1975088 (2)
    colon cancer 13 1 12270759 (1)
    cryptorchidism 12.2 3 14960020 (2), 10037424 (1)


    Export disorders for LBX1 gene to outside databases

    Publications
    for LBX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LBX1 gene, integrated from 9 sources (see all 157):
    (articles sorted by number of sources associating them with LBX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. (PubMed id 8645601)1, 2, 3, 9 Jagla K.... Bellard M. (1995)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese. (PubMed id 22301463)1 Fan Y.H....Luk K.D. (2012)
    5. A genome-wide association study identifies common var iants near LBX1 associated with adolescent idiopathic scoliosis. (PubMed id 22019779)1 Takahashi Y....Ikegawa S. (2011)
    6. A developmentally regulated inducer of EMT, LBX1, con tributes to breast cancer progression. (PubMed id 19651985)1 Yu M....Haber D.A. (2009)
    7. The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. (PubMed id 16600870)1 Kong L.-J.... Nevins J.R. (2006)
    8. A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24. (PubMed id 12913067)1 de Mollerat X.J.... Schwartz C.E. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Characterization of Amphioxus AmphiVent, an evolutionarily conserved marker for chordate ventral mesoderm. (PubMed id 11309850)1 Kozmik Z....Holland N.D. (2001)

    External Searches for LBX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing LBX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10660 HGNC: 16960 AceView: LBX1 Ensembl:ENSG00000138136 euGenes: HUgn10660
    ECgene: LBX1 H-InvDB: LBX1

    Other Databases showing LBX1 gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing LBX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LBX1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LBX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LBX1 gene:
    Search GeneIP for patents involving LBX1

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