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Aliases for LBX1 Gene

Aliases for LBX1 Gene

  • Ladybird Homeobox 1 2 3
  • Ladybird Homeobox Protein Homolog 1 3 4
  • LBX1H 3 4
  • Transcription Factor Similar To D. Melanogaster Homeodomain Protein Lady Bird Late 3
  • Ladybird Homeobox Homolog 1 (Drosophila) 2
  • Ladybird Homeobox Homolog 1 3
  • Lady Bird-Like Homeobox 3
  • Homeobox 3
  • HPX-6 3
  • HPX6 3

External Ids for LBX1 Gene

Previous GeneCards Identifiers for LBX1 Gene

  • GC10M101879
  • GC10M102220
  • GC10M103117
  • GC10M102651
  • GC10M102976
  • GC10M096616

Summaries for LBX1 Gene

Entrez Gene Summary for LBX1 Gene

  • This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]

GeneCards Summary for LBX1 Gene

LBX1 (Ladybird Homeobox 1) is a Protein Coding gene. Diseases associated with LBX1 include currarino triad and leri-weill dyschondrosteosis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for LBX1 Gene

  • Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.

Gene Wiki entry for LBX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LBX1 Gene

Genomics for LBX1 Gene

Regulatory Elements for LBX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LBX1 Gene

Chromosome:
10
Start:
101,226,195 bp from pter
End:
101,230,327 bp from pter
Size:
4,133 bases
Orientation:
Minus strand

Genomic View for LBX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for LBX1 Gene

Proteins for LBX1 Gene

  • Protein details for LBX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52954-LBX1_HUMAN
    Recommended name:
    Transcription factor LBX1
    Protein Accession:
    P52954
    Secondary Accessions:
    • B9EGA2
    • Q05BB2

    Protein attributes for LBX1 Gene

    Size:
    281 amino acids
    Molecular mass:
    30221 Da
    Quaternary structure:
    • Interacts with SKOR1 which acts as a transcriptional corepressor.

neXtProt entry for LBX1 Gene

Proteomics data for LBX1 Gene at MOPED

Post-translational modifications for LBX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LBX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LBX1 Gene

Domains & Families for LBX1 Gene

Gene Families for LBX1 Gene

Suggested Antigen Peptide Sequences for LBX1 Gene

Graphical View of Domain Structure for InterPro Entry

P52954

UniProtKB/Swiss-Prot:

LBX1_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with LBX1: view

Function for LBX1 Gene

Molecular function for LBX1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.

Gene Ontology (GO) - Molecular Function for LBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with LBX1: view
genes like me logo Genes that share phenotypes with LBX1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LBX1 Gene

Localization for LBX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LBX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LBX1 Gene COMPARTMENTS Subcellular localization image for LBX1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for LBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with LBX1: view

Pathways & Interactions for LBX1 Gene

SuperPathways for LBX1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007517 muscle organ development IEA --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with LBX1: view

No data available for Pathways by source and SIGNOR curated interactions for LBX1 Gene

Drugs & Compounds for LBX1 Gene

(2) Additional Compounds for LBX1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oligonucleotide
retinoic acid
302-79-4
genes like me logo Genes that share compounds with LBX1: view

Transcripts for LBX1 Gene

mRNA/cDNA for LBX1 Gene

(2) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LBX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LBX1 Gene

No ASD Table

Relevant External Links for LBX1 Gene

GeneLoc Exon Structure for
LBX1
ECgene alternative splicing isoforms for
LBX1

Expression for LBX1 Gene

mRNA expression in normal human tissues for LBX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LBX1 Gene

This gene is overexpressed in Muscle - Skeletal (x40.9) and Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for LBX1 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LBX1 Gene



SOURCE GeneReport for Unigene cluster for LBX1 Gene Hs.37128

genes like me logo Genes that share expression patterns with LBX1: view

Protein tissue co-expression partners for LBX1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LBX1 Gene

Orthologs for LBX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LBX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LBX1 35
  • 93.56 (n)
  • 96.28 (a)
LBX1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LBX1 35
  • 94.42 (n)
  • 97.4 (a)
LBX1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lbx1 35
  • 91.82 (n)
  • 96.65 (a)
Lbx1 16
Lbx1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LBX1 35
  • 99.88 (n)
  • 99.64 (a)
LBX1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lbx1 35
  • 92.69 (n)
  • 96.65 (a)
oppossum
(Monodelphis domestica)
Mammalia LBX1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LBX1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lbx1 35
  • 69.7 (n)
  • 77.87 (a)
zebrafish
(Danio rerio)
Actinopterygii lbx1a 35
  • 68.73 (n)
  • 74.42 (a)
lbx1h 35
lbx1a 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lbl 37
  • 75 (a)
lbe 36
  • 21 (a)
ManyToMany
lbl 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for LBX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LBX1 Gene

ENSEMBL:
Gene Tree for LBX1 (if available)
TreeFam:
Gene Tree for LBX1 (if available)

Paralogs for LBX1 Gene

(5) SIMAP similar genes for LBX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LBX1: view

Variants for LBX1 Gene

Sequence variations from dbSNP and Humsavar for LBX1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1322331 -- 101,226,832(-) GGGAG(G/T)GGCAG downstream-variant-500B, utr-variant-3-prime
rs12776802 -- 101,227,470(+) GGCCT(C/G)CGAGT missense, reference
rs12776825 -- 101,227,506(+) GATGT(C/T)CATCT missense, reference
rs12776987 -- 101,227,551(+) GTCGG(C/G)CTTCA missense, reference
rs12777128 -- 101,227,472(+) CCTCC(C/G)AGTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LBX1 Gene

Variant ID Type Subtype PubMed ID
nsv831966 CNV Gain 17160897

Variation tolerance for LBX1 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LBX1 Gene

HapMap Linkage Disequilibrium report
LBX1
Human Gene Mutation Database (HGMD)
LBX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LBX1 Gene

Disorders for LBX1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for LBX1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
currarino triad
  • currarino syndrome
leri-weill dyschondrosteosis
  • leri weill dyschondrosteosis
bone structure disease
adolescent idiopathic scoliosis
  • ais
idiopathic scoliosis
  • scoliosis idiopathic
- elite association
Search LBX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LBX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LBX1
genes like me logo Genes that share disorders with LBX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LBX1 Gene

Publications for LBX1 Gene

  1. Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. (PMID: 8645601) Jagla K. … Bellard M. (Mech. Dev. 1995) 2 23 67
  2. [Research on the differently expressed homeobox genes related to adenoid cystic carcinoma]. (PMID: 20480666) Xia H. … Gao N. (Hua Xi Kou Qiang Yi Xue Za Zhi 2010) 23 67
  3. Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity. (PMID: 19106744) Takahashi K. … Haneda M. (Pancreas 2009) 23 67
  4. Morphogenetic fields within the human dentition: a new, clinically relevant synthesis of an old concept. (PMID: 18760768) Townsend G. … Brook A. (Arch. Oral Biol. 2009) 23 67
  5. The non-conserved C-terminal segments of Sine Oculis Homeobox (SIX) proteins confer functional specificity. (PMID: 19422020) Weasner B.P. … Kumar J.P. (Genesis 2009) 23 67

Products for LBX1 Gene

Sources for LBX1 Gene

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