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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LBX1 Gene

protein-coding   GIFtS: 50
GCID: GC10M102976

Ladybird Homeobox 1

(Previous name: ladybird homeobox homolog 1 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ladybird Homeobox 11 2     homeobox2
LBX1H2 3 5     Lady Bird-Like Homeobox2
Ladybird Homeobox Protein Homolog 12 3     Ladybird Homeobox Homolog 12
Ladybird Homeobox Homolog 1 (Drosophila)1     Transcription Factor LBX12
HPX-62     Transcription Factor Similar To D. Melanogaster Homeodomain Protein Lady
Bird Late2
HPX62     

External Ids:    HGNC: 169601   Entrez Gene: 106602   Ensembl: ENSG000001381367   OMIM: 6042555   UniProtKB: P529543   

Export aliases for LBX1 gene to outside databases

Previous GC identifers: GC10M101879 GC10M102220 GC10M103117 GC10M102651 GC10M096616


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LBX1 Gene:
This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late
homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for
the acquisition of dorsal identities of forelimb muscles. (provided by RefSeq, Jul 2008)

GeneCards Summary for LBX1 Gene: 
LBX1 (ladybird homeobox 1) is a protein-coding gene. Diseases associated with LBX1 include leri weill dyschondrosteosis, and adenoid cystic carcinoma. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
Function: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the
spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm
and hypoglossal cord (By similarity)

Gene Wiki entry for LBX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LBX1 gene promoter:
         COUP-TF1   Lmo2   COUP   Nkx2-5   HNF-4alpha2   HNF-4alpha1   COUP-TF   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLBX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LBX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LBX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.32

LBX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LBX1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M102976:  view genomic region     (about GC identifiers)

Start:
102,986,733 bp from pter      End:
102,989,551 bp from pter
Size:
2,819 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954 (See protein sequence)
Recommended Name: Transcription factor LBX1  
Size: 281 amino acids; 30221 Da
Subunit: Interacts with SKOR1 which acts as a transcriptional corepressor (By similarity)
Subcellular location: Nucleus (Probable)
Secondary accessions: B9EGA2 Q05BB2

Explore the universe of human proteins at neXtProt for LBX1: NX_P52954

Explore proteomics data for LBX1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52954

  • LBX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LBX1 Protein Expression
    REFSEQ proteins: NP_006553.2  
    ENSEMBL proteins: 
     ENSP00000359212  

    Human Recombinant Protein Products for LBX1: 
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    Novus Biologicals LBX1 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LBX1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    LBX1 for ontologies           About GeneDecksing



    LBX1 Antibody Products: 
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    Assay Products for LBX1: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for LBX1 
    Cloud-Clone Corp. CLIAs for LBX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P52954

    ProtoNet protein and cluster: P52954

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
    Similarity: Contains 1 homeobox DNA-binding domain


    LBX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LBX1_HUMAN, P52954
    Function: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the
    spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm
    and hypoglossal cord (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding ----
         
    LBX1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LBX1:
     Decreased circadian period len  Increased HPV18 LCR reporter a  Increased cell number in G1, s 

         10 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Lbx1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    LBX1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LBX1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LBX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LBX1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LBX1 

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LBX1 (see all 9):
    hsa-miR-92a hsa-miR-137 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-4267 hsa-miR-363 hsa-miR-3177-3p
    SwitchGear 3'UTR luciferase reporter plasmidLBX1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LBX1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LBX1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for LBX1 (P529543 ENSP000003592124) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKOR1P845503, ENSP000003736544I2D: score=1 STRING: ENSP00000373654
    AP5B1Q2VPB73I2D: score=1 
    CCNKO759093I2D: score=1 
    DGCR6LQ9BY273I2D: score=1 
    FXR2P511163I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001947heart looping IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007517muscle organ development IEA--
    GO:0008285negative regulation of cell proliferation IEA--

    LBX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LBX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LBX1

    2 Novoseek inferred chemical compound relationships for LBX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 41 10 8104620 (3), 1975088 (2), 1976508 (1), 1683800 (1) (see all 6)
    oligonucleotide 7.72 4 8570656 (1), 8103988 (1), 10402242 (1)

    Search CenterWatch for drugs/clinical trials and news about LBX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LBX1 gene: 
    NM_006562.4  

    Unigene Cluster for LBX1:

    Ladybird homeobox 1
    Hs.37128
    Unigene Representative Sequence: BC069156
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370193(uc001ksx.3)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LBX1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LBX1 (see all 9):
    hsa-miR-92a hsa-miR-137 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-4267 hsa-miR-363 hsa-miR-3177-3p
    SwitchGear 3'UTR luciferase reporter plasmidLBX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LBX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LBX1
    Clone
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    OriGene clones in human, mouse for LBX1 (see all 6)
    OriGene ORF clones in mouse, rat for LBX1
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    GenScript: all cDNA clones in your preferred vector: LBX1 (NM_006562)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LBX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LBX1
    Sirion Biotech Customized lentivirus for stable overexpression of LBX1 
                         Customized lentivirus expression plasmids for stable overexpression of LBX1 
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    Products:
        
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LBX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LBX1

    Additional mRNA sequence: 

    AJ004949.1 BC069156.1 BC136321.1 X74863.1 

    1 DOTS entry:

    DT.92414048 

    6 AceView cDNA sequences:

    X74863 BV197771 BC069156 X90828 NM_006562 AJ004949 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LBX1 expression in normal human tissues (normalized intensities)      LBX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LBX1 Expression
    About this image


    LBX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 13 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             gastrocnemius   
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             dI6 Interneurons dP6 Neural Domain
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Hippocampus

    See LBX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LBX1

    SOURCE GeneReport for Unigene cluster: Hs.37128
        SABiosciences Expression via Pathway-Focused PCR Array including LBX1: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LBX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LBX1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lbx11 , 5 ladybird homeobox homolog 1 (Drosophila)1, 5 92.05(n)1
    97.15(a)1
      19 (38.61 cM)5
    168141  NM_010691.51  NP_034821.21 
     452326885 
    lizard
    (Anolis carolinensis)
    Reptilia LBX16
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL343239.1(554933-558601)
    zebrafish
    (Danio rerio)
    Actinopterygii lbx1h2 lady bird-like homeobox 1 homolog, (Drosophila) 79.32(n)   64276  AJ295165.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lbl3 regulation of transcription specific
    RNA polymerase more
    75(a)   93E1   --


    ENSEMBL Gene Tree for LBX1 (if available)
    TreeFam Gene Tree for LBX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LBX1 gene
    DLX22  BARX12  NKX1-12  VENTX2  BARHL12  BARHL22  BARX22  DLX12  
    DLX32  LBX22  NKX1-22  BSX2  DLX52  DLX62  DLX42  MSX22  
    MSX12  
    5 SIMAP similar genes for LBX1 using alignment to 1 protein entry:     LBX1_HUMAN:
    HPX-6    HOXB1    HOXA4    HLX    LBX2

    LBX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 SNPs in LBX1 are shown (see all 93)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887328161,2
    --103347471(+) TCCCCC/TTGCAT 1 -- ds50010--------
    rs1473771431,2
    --103347612(+) GGGGAA/GGAAAG 1 -- ds50010--------
    rs3769305861,2
    C--103347777(+) CAAAA-/CCAGCC 1 -- ds50010--------
    rs13223311,2
    C,F,A,H--103347792(-) GGGAGG/TGGCAG 1 -- ds500126Minor allele frequency- T:0.50EA NA NS WA CSA 2480
    rs1812401941,2
    --103347996(+) CACGGC/GGAGGG 1 -- ut310--------
    rs1509187571,2
    C,F--103348228(+) GCGCCG/ACTCAA 1 -- ut311Minor allele frequency- A:0.01NA 3900
    rs1448707901,2
    C--103348300(+) GGTCCG/ATGAGC 2 /T /M mis11Minor allele frequency- A:0.00NA 3626
    rs2001553231,2
    C--103348362(+) CCTGGC/GGGGAG 2 P syn10--------
    rs1998197841,2
    C--103348363(+) CTGGGG/TGGAGG 2 H P mis10--------
    rs1996354681,2
    --103348427(+) TGTGGC/TCTCCG 2 T A mis10--------

    HapMap Linkage Disequilibrium report for LBX1 (102986733 - 102989551 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LBX1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831966CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LBX1
    DNA2.0 Custom Variant and Variant Library Synthesis for LBX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604255    OMIM disorders: --

    20/33 diseases for LBX1 (see all 33):    About MalaCards
    leri weill dyschondrosteosis    adenoid cystic carcinoma    split foot    cryptorchidism
    teratocarcinoma    acute leukemia    split hand    short stature
    scoliosis    metabolic disorders    esophageal squamous cell carcinoma    adenoiditis
    osteosarcoma    brachydactyly    hemangioma    neuroblastoma
    prostate cancer    esophagitis    ovarian cancer    lung cancer


    LBX1 for disorders           About GeneDecksing

    10/26 Novoseek inferred disease relationships for LBX1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 50.8 4 10905048 (2), 9292516 (1), 9885434 (1)
    leukemia 37.7 10 1358259 (1), 9592016 (1), 16525506 (1), 9292516 (1) (see all 9)
    congenital malformation 25.8 3 9274447 (1), 1351112 (1), 17062780 (1)
    teratocarcinoma 25.7 1 7622051 (1)
    acute leukemia 21.3 2 7680402 (1), 10905048 (1)
    neoplastic transformation 21.1 2 8105782 (1), 11889211 (1)
    cancer 20.2 27 12360280 (3), 1977958 (3), 12908068 (3), 14667497 (2) (see all 15)
    carcinoma embryonal 14.6 2 1975088 (2)
    colon cancer 13 1 12270759 (1)
    cryptorchidism 12.2 3 14960020 (2), 10037424 (1)


    Export disorders for LBX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LBX1 gene, integrated from 9 sources (see all 159):
    (articles sorted by number of sources associating them with LBX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. (PubMed id 8645601)1, 2, 3, 9 Jagla K.... Bellard M. (1995)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Association between common variants near LBX1 and adol escent idiopathic scoliosis replicated in the Chinese Han population. (PubMed id 23308168)1 Gao W....Huang D. (2013)
    5. Association of rs11190870 near LBX1 with adolescent id iopathic scoliosis susceptibility in a Han Chinese population. (PubMed id 23096252)1 Jiang H....Qiu Y. (2013)
    6. SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese. (PubMed id 22301463)1 Fan Y.H....Luk K.D. (2012)
    7. A genome-wide association study identifies common var iants near LBX1 associated with adolescent idiopathic scoliosis. (PubMed id 22019779)1 Takahashi Y....Ikegawa S. (2011)
    8. A developmentally regulated inducer of EMT, LBX1, con tributes to breast cancer progression. (PubMed id 19651985)1 Yu M....Haber D.A. (2009)
    9. The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. (PubMed id 16600870)1 Kong L.-J.... Nevins J.R. (2006)
    10. A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24. (PubMed id 12913067)1 de Mollerat X.J.... Schwartz C.E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10660 HGNC: 16960 AceView: LBX1 Ensembl:ENSG00000138136 euGenes: HUgn10660
    ECgene: LBX1 H-InvDB: LBX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LBX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LBX1 gene:
    Search GeneIP for patents involving LBX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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