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LBX1 Gene

protein-coding   GIFtS: 49
GCID: GC10M102976

Ladybird Homeobox 1

(Previous name: ladybird homeobox homolog 1 (Drosophila))
  See LBX1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ladybird Homeobox 11 2     homeobox2
LBX1H2 3 5     Lady Bird-Like Homeobox2
Ladybird Homeobox Protein Homolog 12 3     Ladybird Homeobox Homolog 12
Ladybird Homeobox Homolog 1 (Drosophila)1     Transcription Factor LBX12
HPX-62     Transcription Factor Similar To D. Melanogaster Homeodomain Protein Lady
Bird Late2
HPX62     

External Ids:    HGNC: 169601   Entrez Gene: 106602   Ensembl: ENSG000001381367   OMIM: 6042555   UniProtKB: P529543   

Export aliases for LBX1 gene to outside databases

Previous GC identifers: GC10M101879 GC10M102220 GC10M103117 GC10M102651 GC10M096616


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LBX1 Gene:
This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late
homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for
the acquisition of dorsal identities of forelimb muscles. (provided by RefSeq, Jul 2008)

GeneCards Summary for LBX1 Gene:
LBX1 (ladybird homeobox 1) is a protein-coding gene. Diseases associated with LBX1 include split foot, and adenoid cystic carcinoma. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
Function: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the
spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm
and hypoglossal cord (By similarity)

Gene Wiki entry for LBX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LBX1 gene promoter:
         COUP-TF1   Lmo2   COUP   Nkx2-5   HNF-4alpha2   HNF-4alpha1   COUP-TF   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLBX1 promoter sequence
   Search Chromatin IP Primers for LBX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LBX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.32

LBX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LBX1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M102976:  view genomic region     (about GC identifiers)

Start:
102,986,733 bp from pter      End:
102,989,551 bp from pter
Size:
2,819 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954 (See protein sequence)
Recommended Name: Transcription factor LBX1  
Size: 281 amino acids; 30221 Da
Subunit: Interacts with SKOR1 which acts as a transcriptional corepressor (By similarity)
Secondary accessions: B9EGA2 Q05BB2

Explore the universe of human proteins at neXtProt for LBX1: NX_P52954

Explore proteomics data for LBX1 at MOPED


See LBX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006553.2  
ENSEMBL proteins: 
 ENSP00000359212  

LBX1 Human Recombinant Protein Products:

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Novus Biologicals LBX1 Protein
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for LBX1

 
Search eBioscience for Proteins for LBX1 

LBX1 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of LBX1
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Browse OriGene Antibodies
OriGene Custom Antibody Services for LBX1
Novus Biologicals LBX1 Antibodies
Abcam antibodies for LBX1
Cloud-Clone Corp. Antibodies for LBX1
Search ThermoFisher Antibodies for LBX1
LSBio Antibodies in human, mouse, rat for LBX1

LBX1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for LBX1
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GenScript Custom Assay Services for LBX1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for LBX1
Cloud-Clone Corp. CLIAs for LBX1
Search eBioscience for ELISAs for LBX1 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
NKL: Homeoboxes / ANTP class : NKL subclass

4 InterPro protein domains:
 IPR000047 HTH_motif
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P52954

ProtoNet protein and cluster: P52954

1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with LBX1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LBX1_HUMAN, P52954
Function: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the
spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm
and hypoglossal cord (By similarity)

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0005515protein binding ----
GO:0043565sequence-specific DNA binding ----
     
Find genes that share ontologies with LBX1           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for LBX1:
 Decreased circadian period len  Increased HPV18 LCR reporter a  Increased cell number in G1, s 

     10 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Lbx1):
 behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
 limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

Find genes that share phenotypes with LBX1           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LBX1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LBX1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LBX1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LBX1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat LBX1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LBX1 (see all 9):
hsa-miR-92a hsa-miR-137 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-4267 hsa-miR-363 hsa-miR-3177-3p
SwitchGear 3'UTR luciferase reporter plasmidLBX1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for LBX1
Predesigned siRNA for gene silencing in human, mouse, rat LBX1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for LBX1

Clone
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OriGene clones in human, mouse for LBX1 (see all 5)
OriGene ORF clones in mouse, rat for LBX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LBX1 (NM_006562)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LBX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LBX1

Cell Line
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GenScript Custom overexpressing Cell Line Services for LBX1
Browse ESI BIO Cell Lines and PureStem Progenitors for LBX1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LBX1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LBX1_HUMAN, P52954: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005667transcription factor complex IEA--

Find genes that share ontologies with LBX1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including LBX1: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for LBX1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for LBX1 (P529543 ENSP000003592124) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
SKOR1P845503, ENSP000003736544I2D: score=1 STRING: ENSP00000373654
TLE1Q047243, ENSP000003656824I2D: score=1 STRING: ENSP00000365682
AP5B1Q2VPB73I2D: score=1 
CCNKO759093I2D: score=1 
DGCR6LQ9BY273I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001947heart looping IEA--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007517muscle organ development IEA--
GO:0008285negative regulation of cell proliferation IEA--

Find genes that share ontologies with LBX1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LBX1

2 Novoseek inferred chemical compound relationships for LBX1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid 41 10 8104620 (3), 1975088 (2), 1976508 (1), 1683800 (1) (see all 6)
oligonucleotide 7.72 4 8570656 (1), 8103988 (1), 10402242 (1)



Find genes that share compounds with LBX1           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for LBX1 gene: 
NM_006562.4  

Unigene Cluster for LBX1:

Ladybird homeobox 1
Hs.37128
Unigene Representative Sequence: BC069156
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000370193(uc001ksx.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat LBX1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LBX1 (see all 9):
hsa-miR-92a hsa-miR-137 hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-4267 hsa-miR-363 hsa-miR-3177-3p
SwitchGear 3'UTR luciferase reporter plasmidLBX1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for LBX1
Predesigned siRNA for gene silencing in human, mouse, rat LBX1
Clone
Products:
     
OriGene clones in human, mouse for LBX1 (see all 5)
OriGene ORF clones in mouse, rat for LBX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LBX1 (NM_006562)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LBX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LBX1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for LBX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LBX1
  QuantiTect SYBR Green Assays in human, mouse, rat LBX1
  QuantiFast Probe-based Assays in human, mouse, rat LBX1

Additional mRNA sequence: 

AJ004949.1 BC069156.1 BC136321.1 X74863.1 

1 DOTS entry:

DT.92414048 

6 AceView cDNA sequences:

X74863 BC069156 BV197771 NM_006562 X90828 AJ004949 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LBX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
LBX1 Expression
About this image


LBX1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 12 entries
         Limb Muscle Progenitor Cells Forelimb Myotome
 
 Somite (Muscoskeletal System)    fully expand to see all 2 entries
         Muscle Progenitor Cells Cervical Ventrolateral Dermomyotome Lip
 
 Limb (Muscoskeletal System)    fully expand to see all 6 entries
         Limb Muscle Progenitor Cells Forelimb Myotome
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Hippocampus
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
LBX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LBX1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.37128
    Pathway & Disease-focused RT2 Profiler PCR Array including LBX1: 
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for LBX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LBX1
QuantiTect SYBR Green Assays in human, mouse, rat LBX1
QuantiFast Probe-based Assays in human, mouse, rat LBX1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LBX1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LBX1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lbx11 , 5 ladybird homeobox homolog 1 (Drosophila)1, 5 91.82(n)1
96.65(a)1
  19 (38.61 cM)5
168141  NM_010691.51  NP_034821.21 
 452326885 
lizard
(Anolis carolinensis)
Reptilia LBX16
ladybird homeobox 1
67(a)
1 ↔ 1
GL343239.1(554933-558601)
tropical clawed frog
(Xenopus tropicalis)
Amphibia lbx11 transcription factor similar to D. melanogaster homeodomain more 69.7(n)
77.87(a)
  780014  NM_001079091.1  NP_001072559.1 
zebrafish
(Danio rerio)
Actinopterygii lbx1h2 lady bird-like homeobox 1 homolog, (Drosophila) 79.32(n)   64276  AJ295165.1 
fruit fly
(Drosophila melanogaster)
Insecta lbl3 regulation of transcription specific
RNA polymerase more
75(a)   93E1   --


ENSEMBL Gene Tree for LBX1 (if available)
TreeFam Gene Tree for LBX1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LBX1 gene
DLX22  BARX12  GBX12  NKX1-12  VENTX2  GBX22  BARHL12  BARHL22  
MNX12  BARX22  DLX12  DLX32  LBX22  NKX1-22  BSX2  DLX52  
DLX62  DLX42  MSX22  MSX12  
5 SIMAP similar genes for LBX1 using alignment to 1 protein entry:     LBX1_HUMAN:
HPX-6    HOXB1    HOXA4    HLX    LBX2

Find genes that share paralogs with LBX1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LBX1 (see all 93)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1887328161,2
--103347471(+) TCCCCC/TTGCAT 1 -- ds50010--------
rs1473771431,2
--103347612(+) GGGGAA/GGAAAG 1 -- ds50010--------
rs3769305861,2
C--103347777(+) CAAAA-/CCAGCC 1 -- ds50010--------
rs13223311,2
C,F,A,H--103347792(-) GGGAGG/TGGCAG 1 -- ds500126Minor allele frequency- T:0.50EA NA NS WA CSA 2480
rs1812401941,2
--103347996(+) CACGGC/GGAGGG 1 -- ut310--------
rs1509187571,2
C,F--103348228(+) GCGCCG/ACTCAA 1 -- ut311Minor allele frequency- A:0.01NA 3900
rs1448707901,2
C--103348300(+) GGTCCG/ATGAGC 2 /T /M mis11Minor allele frequency- A:0.00NA 3626
rs2001553231,2
C--103348362(+) CCTGGC/GGGGAG 2 P syn10--------
rs1998197841,2
C--103348363(+) CTGGGG/TGGAGG 2 H P mis10--------
rs1996354681,2
--103348427(+) TGTGGC/TCTCCG 2 T A mis10--------

HapMap Linkage Disequilibrium report for LBX1 (102986733 - 102989551 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for LBX1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv831966CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LBX1
DNA2.0 Custom Variant and Variant Library Synthesis for LBX1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604255    OMIM disorders: --

5 diseases for LBX1:    
About MalaCards
split foot    adenoid cystic carcinoma    burns    split hand
osteosarcoma


Find genes that share disorders with LBX1           About GenesLikeMe

Selected Novoseek inferred disease relationships for LBX1 gene (see all 26)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemogenesis 50.8 4 10905048 (2), 9292516 (1), 9885434 (1)
leukemia 37.7 10 1358259 (1), 9592016 (1), 16525506 (1), 9292516 (1) (see all 9)
congenital malformation 25.8 3 9274447 (1), 1351112 (1), 17062780 (1)
teratocarcinoma 25.7 1 7622051 (1)
acute leukemia 21.3 2 7680402 (1), 10905048 (1)
neoplastic transformation 21.1 2 8105782 (1), 11889211 (1)
cancer 20.2 27 12360280 (3), 1977958 (3), 12908068 (3), 14667497 (2) (see all 15)
carcinoma embryonal 14.6 2 1975088 (2)
colon cancer 13 1 12270759 (1)
cryptorchidism 12.2 3 14960020 (2), 10037424 (1)


Export disorders for LBX1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LBX1 gene, integrated from 10 sources (see all 159):
(articles sorted by number of sources associating them with LBX1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. (PubMed id 8645601)1, 2, 3, 9 Jagla K.... Bellard M. (Mech. Dev. 1995)
  2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population. (PubMed id 23308168)1 Gao W....Huang D. (PLoS ONE 2013)
  5. Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population. (PubMed id 23096252)1 Jiang H....Qiu Y. (Eur Spine J 2013)
  6. SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese. (PubMed id 22301463)1 Fan Y.H....Luk K.D. (J. Hum. Genet. 2012)
  7. A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. (PubMed id 22019779)1 Takahashi Y....Ikegawa S. (Nat. Genet. 2011)
  8. A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression. (PubMed id 19651985)1 Yu M....Haber D.A. (amp 2009)
  9. The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. (PubMed id 16600870)1 Kong L.-J.... Nevins J.R. (Mol. Cell 2006)
  10. A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24. (PubMed id 12913067)1 de Mollerat X.J.... Schwartz C.E. (Hum. Mol. Genet. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10660 HGNC: 16960 AceView: LBX1 Ensembl:ENSG00000138136 euGenes: HUgn10660
ECgene: LBX1 H-InvDB: LBX1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for LBX1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LBX1 gene:
Search GeneIP for patents involving LBX1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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