V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

LBX1 Gene

protein-coding   GIFtS: 54

GC10M102976
ladybird homeobox 1
(Previous name: ladybird homeobox homolog 1 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
HPX-6 2
HPX6 1, 2
LBX1H 1, 2, 3, 5
OTTHUMP00000180669 2
homeobox 2
Descriptions
Ladybird homeobox protein homolog 1 3
lady bird-like homeobox 2
ladybird homeobox 1 2
ladybird homeobox homolog 1 2
ladybird homeobox homolog 1 (Drosophila) 1
transcription factor similar to D. melanogaster homeodomain
protein lady bird late 2
External Ids
HGNC: 169601
Entrez Gene: 106602
UniProtKB: P529543
Ensembl: ENSG000001381367
Search outside databases for aliases for LBX1 gene

Previous GC identifers: GC10M101879 GC10M102220 GC10M103117 GC10M102651

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LBX1:
This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird
early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell
migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided
by RefSeq]

UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
Function: Transcription factor required for the development of GABAergic interneurons in the dorsal
horn of the spinal cord and migration and further development of hypaxial muscle precursor cells
for limb muscles, diaphragm and hypoglossal cord (By similarity)

Gene Wiki entry for LBX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LBX1 gene  

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.32

LBX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M102976:     (about GC identifiers)

Start:
102,976,723 bp from pter
End:
102,978,707 bp from pter
Size:
1,985 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954 (See protein sequence)
Recommended Name: Transcription factor LBX1  
Size: 281 amino acids; 30221 Da
Subunit: Interacts with LBXCOR1 which acts as a transcriptional corepressor (By similarity)
Subcellular location: Nucleus (Probable)
Secondary accessions: Q05BB2

REFSEQ proteins: NP_006553.2  

ENSEMBL proteins: 
ENSP00000359212 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (LBX1)
Human Recombinant Proteins from Abnova (LBX1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005667 transcription factor complex IEA--
About this table

Antibodies for LBX1: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of LBX1
Sigma-Aldrich Antibodies for LBX1
Browse R&D Systems for Antibodies
Antibodies from Abcam (LBX1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (LBX1)
Novus Biologicals Antibodies for LBX1

Assays for LBX1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5 InterPro domains/families:
 IPR000047 HTH_lambrepressr
 IPR001356 Homeobox
 IPR017970 Homeobox_CS
 IPR015704 Lbx_related
 IPR012287 Homeodomain-rel


   GeneDecks  LBX1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P52954

ProtoNet protein and cluster: P52954

1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
Similarity: Contains 1 homeobox DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LBX1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (LBX1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006562

              Applied Biosystems Silencer® siRNAs for LBX1

              Sigma-Aldrich siRNA for LBX1  
                     Sigma-Aldrich shRNA for LBX1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006562
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006562
                                 untagged cDNA clone in CMV expression vector: NM_006562 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_006562

UniProtKB/Swiss-Prot: LBX1_HUMAN, P52954
Function: Transcription factor required for the development of GABAergic interneurons in the dorsal
horn of the spinal cord and migration and further development of hypaxial muscle precursor cells
for limb muscles, diaphragm and hypoglossal cord (By similarity)

8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Lbx1):

behavior/neurologicalembryogenesislethality-prenatal/perinatallimbs/digits/tail
musclenervous systemno phenotypic analysis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity IEA--
GO:0005515 protein binding IEA--
GO:0043565 sequence-specific DNA binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/13 Interacting proteins for LBX1 (ENSP000003592123) via UniProtKB, MINT, and/or STRING (see all 13 )
InteractantInteraction Details
GeneCardExternal ID(s)
LBXCOR1ENSP000003693743STRING (score=.962)
SIX1ENSP000002471823STRING (score=.903)
FBXW4ENSP000003591493STRING (score=.876)
NPYENSP000002421523STRING (score=.84)
RP11-529I10.4ENSP000003591703STRING (score=.836)
About this table

5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0001947 heart looping IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0007275 multicellular organismal development IEA--
GO:0007399 nervous system development IEA--
GO:0007519 skeletal muscle development IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LBX1
1 Novoseek chemical compound relationship for LBX1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide 9.06 4 8570656 (1), 8103988 (1), 10402242 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LBX1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (LBX1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006562

              Sigma-Aldrich siRNA for LBX1  
                     Sigma-Aldrich shRNA for LBX1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006562  

REFSEQ mRNAs for LBX1 gene: 

NM_006562.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006562  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006562
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006562
                                 untagged cDNA clone in CMV expression vector: NM_006562 

Additional cDNA sequence: 

AJ004949.1 BC069156.1 BC136321.1 X74863.1 

1 DOTS entry:

DT.92414048 

6 AceView cDNA sequences:

X74863 BV197771 BC069156 X90828 NM_006562 AJ004949 

highest scoring ESTs for LBX1:

BC069156 NM_006562 X90828 AJ004949 X74863 

Unigene Cluster for LBX1:

Ladybird homeobox 1
Hs.37128
Unigene Representative Sequence: BC069156


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000370193  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LBX1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for LBX1

1 / 2 / 3

3 probe-sets matching LBX1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

31513_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X90828 0.60 1.00 0.82 1

208380_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006562 0.60 1.00 0.82 1

208380_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.37128

Expression variation in blood from EXPOLDB for LBX1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for LBX1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LBX11   -- ladybird homeobox 1 94.66(n)
97.51(a)
486850  XM_543979.2  XP_543979.1 
chimpanzee
(Pan troglodytes)
LBX11   -- ladybird homeobox 1 99.88(n)
99.64(a)
466187  XM_521589.2  XP_521589.1 
cow
(Bos taurus)
LBX11   -- ladybird homeobox 1 93.71(n)
96.44(a)
534470  XM_614245.3  XP_614245.3 
rat
(Rattus norvegicus)
Lbx11   -- ladybird homeobox 1 92.88(n)
97.15(a)
499362  XM_574675.2  XP_574675.2 
mouse
(Mus musculus)
Lbx11, 5 195
ladybird homeobox homolog 1 (Drosophila)1, 5 92.05(n)1
97.15(a)1
168141  NM_010691.51  NP_034821.21 
 AB1084975  AK1445625  (see all 8)
About this table        Species with no ortholog for LBX1

ENSEMBL Gene Tree for LBX1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for LBX1 gene
NKX3-22  BSX2  LBX22  NKX3-12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/13 NCBI SNPs in LBX1 are shown (see all 13 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 24)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs13223311,2
A,C,F,H102976579(-) GGGAGG/TGGCAG 1 -- ng518Minor allele frequency- T:0.50EA NA EU WA 558
rs9419091,2
A,C102978335(-) GGCCGC/TGCGCT 1 R/R syn1 ese30--------
--
rs127769871,2
--102977298(+) GTCGGC/GCTTCA 1 A/P mis1 ese30--------
--
rs127652161,2
--102978750(+) GGCCCC/GGGGAA 1 -- ng310--------
--
rs127771281,2
--102977219(+) CCTCCC/GAGTTC 1 S/W mis1 ese30--------
--
rs127768021,2
--102977217(+) GGCCTC/GCGAGT 1 E/Q mis1 ese30--------
--
rs354486151,2
--102979328(+) CCGAGA/CTGTTT 1 -- ng310--------
--
rs127771401,2
--102977237(+) GTTCGC/GCCAGC 1 A/G mis10--------
--
rs43635261,2
--102976534(+) GCCGGG/TGCATT 1 -- ng510--------
--
rs127768251,2
--102977253(+) GATGTC/TCATCT 1 D/N mis1 ese30--------
About this table

HapMap Linkage Disequilibrium images for LBX1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604255

10/26 Novoseek disease relationships for LBX1 gene (see all 26 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemogenesis 52.09 4 10905048 (2), 9292516 (1), 9885434 (1)
leukemia 37.62 10 1358259 (1), 9592016 (1), 16525506 (1), 9292516 (1) (see all 9)
congenital malformation 27.48 3 9274447 (1), 1351112 (1), 17062780 (1)
teratocarcinoma 26.67 1 7622051 (1)
acute leukemia 22.80 2 7680402 (1), 10905048 (1)
neoplastic transformation 22.52 2 8105782 (1), 11889211 (1)
carcinoma embryonal 15.84 2 1975088 (2)
cancer 15.50 26 12360280 (3), 1977958 (3), 12908068 (3), 14667497 (2) (see all 15)
colon cancer 15.11 1 12270759 (1)
cryptorchidism 13.79 3 14960020 (2), 10037424 (1)
About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/144 PubMed articles for LBX1 gene (see all 144 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10660 HGNC: 16960 AceView: LBX1 Ensembl:ENSG00000138136 euGenes: HUgn10660
ECgene: LBX1 H-InvDB: LBX1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for LBX1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LBX1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for LBX1 Antibodies for LBX1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for LBX1 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (LBX1)
 Antibodies (LBX1)
 Chimera RNAi (LBX1)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(LBX1)
 Antibodies (LBX1)
 Search OriGene for LBX1
 Search Tocris compounds for LBX1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for LBX1

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
LBX1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com