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LBP Gene

protein-coding   GIFtS: 66
GCID: GC20P036974

Lipopolysaccharide Binding Protein

(Previous name: lipopolysaccharide-binding protein)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lipopolysaccharide Binding Protein1 2     BPIFD22
Lipopolysaccharide-Binding Protein1 2     BPI Fold Containing Family D, Member 22
BPI Fold Containing Family D1     LPS-Binding Protein2
Member 21     

External Ids:    HGNC: 65171   Entrez Gene: 39292   Ensembl: ENSG000001299887   OMIM: 1519905   UniProtKB: P184283   

Export aliases for LBP gene to outside databases

Previous GC identifers: GC20P036703 GC20P037613 GC20P037660 GC20P036408 GC20P033709


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LBP Gene:
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial
infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall.
Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts
with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice
suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance
of LPS from circulation. This protein is part of a family of structurally and functionally related proteins,
including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP).
(provided by RefSeq, Apr 2012)

GeneCards Summary for LBP Gene:
LBP (lipopolysaccharide binding protein) is a protein-coding gene. Diseases associated with LBP include infective endocarditis, and bacteremia. GO annotations related to this gene include lipoteichoic acid binding and receptor binding. An important paralog of this gene is PLTP.

UniProtKB/Swiss-Prot: LBP_HUMAN, P18428
Function: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides
(LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer
for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial
lipopolysaccharide

Gene Wiki entry for LBP (Lipopolysaccharide-binding protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the LBP gene promoter:
         HOXA9B   HOXA9   HNF-4alpha2   Meis-1b   HNF-4alpha1   CREB   deltaCREB   TGIF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLBP promoter sequence
   Search Chromatin IP Primers for LBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

LBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LBP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P036974:  view genomic region     (about GC identifiers)

Start:
36,974,759 bp from pter      End:
37,005,665 bp from pter
Size:
30,907 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LBP_HUMAN, P18428 (See protein sequence)
Recommended Name: Lipopolysaccharide-binding protein precursor  
Size: 481 amino acids; 53384 Da
Subunit: When bound to LPS, interacts (via C-terminus) with soluble CD14
Secondary accessions: B2R938 O43438 Q92672 Q9H403 Q9UD66

Explore the universe of human proteins at neXtProt for LBP: NX_P18428

Explore proteomics data for LBP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn300, Asn355, Asn386, Asn394

  • See LBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004130.2  
    ENSEMBL proteins: 
     ENSP00000217407  
    Reactome Protein details: P18428

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BPIF: BPI fold containing

    4 InterPro protein domains:
     IPR017954 Lipid-bd_serum_glycop_CS
     IPR017942 Lipid-bd_serum_glycop_N
     IPR017943 Bactericidal_perm-incr_a/b_dom
     IPR001124 Lipid-bd_serum_glycop_C

    Graphical View of Domain Structure for InterPro Entry P18428

    ProtoNet protein and cluster: P18428

    1 Blocks protein domain: IPB001124 Lipid-binding serum glycoprotein

    UniProtKB/Swiss-Prot: LBP_HUMAN, P18428
    Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family


    LBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LBP_HUMAN, P18428
    Function: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides
    (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer
    for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial
    lipopolysaccharide

         Genatlas biochemistry entry for LBP:
    lipopolysaccharide,acute-phase protein specifically binding to the lipid A moiety of liposaceharide
    (LPS,endotoxin) from the cell wall of Gram- bacteria binding protein,and directing it to the CD14 receptor mainly
    expressed by phagocytes

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001530lipopolysaccharide binding ISS2477488
    GO:0005102receptor binding ISS2477488
    GO:0005515protein binding IPI--
    GO:0008289lipid binding ----
    GO:0070891lipoteichoic acid binding IDA12594207
         
    LBP for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lbp):
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 

    LBP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LBP: Lbptm1Buru Lbptm1Jack

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LBP

    miRNA
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    miRTarBase miRNAs that target LBP:
    hsa-mir-335-5p (MIRT017289), hsa-mir-22-3p (MIRT050450), hsa-mir-186-5p (MIRT045133)

    Block miRNA regulation of human, mouse, rat LBP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LBP:
    hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmidLBP 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): LBP (NM_203346)
    Sino Biological Human cDNA Clone for LBP
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LBP_HUMAN, P18428: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS2477488
    GO:0009986cell surface IDA11528597
    GO:0070062extracellular vesicular exosome IDA19056867

    LBP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LBP About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    3Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Transfer of LPS from LBP carrier to CD140.00
    Cytokine production by Th17 cells in CF Mouse model 0.72
    4Toll Comparative Pathway
    Immune response MIF in innate immunity response0.46
    iNOS Signaling0.34
    5ErbB4 Pathway
    LPS Stimulated MAPK Signaling0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LBP
        iNOS Signaling
    LPS Stimulated MAPK Signaling
    Toll-Like Receptors Pathway

    Selected GeneGo (Thomson Reuters) Pathways for LBP (see all 7)
        Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Transcription NF-kB signaling pathway
    Cytokine production by Th17 cells in CF (Mouse model)
    Immune response TLR signaling pathways

    3 BioSystems Pathways for LBP
        Toll-like receptor signaling pathway
    IL6-mediated signaling events
    Regulation of toll-like receptor signaling pathway


    2 Reactome Pathways for LBP
        Toll Like Receptor 4 (TLR4) Cascade
    Transfer of LPS from LBP carrier to CD14


    4 Kegg Pathways  (Kegg details for LBP):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    Salmonella infection
    Tuberculosis


    LBP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LBP: 
              Innate & Adaptive Immune Responses in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for LBP (P184281, 3 ENSP000002174074) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD14P085713, ENSP000003042364I2D: score=3 STRING: ENSP00000304236
    IRF6O148963, ENSP000003559884I2D: score=1 STRING: ENSP00000355988
    APOA1P026473, ENSP000002368504I2D: score=3 STRING: ENSP00000236850
    CFHR1Q035913, ENSP000003142994I2D: score=3 STRING: ENSP00000314299
    PRDX4Q131621, ENSP000003686464EBI-3927059,EBI-2211957 STRING: ENSP00000368646
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002232leukocyte chemotaxis involved in inflammatory response IEA--
    GO:0002281macrophage activation involved in immune response ISS2402637
    GO:0006953acute-phase response ISS2477488
    GO:0006968cellular defense response ISS2402637

    LBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LBP

    Selected HMDB Compounds for LBP (see all 519)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

    Selected Novoseek inferred chemical compound relationships for LBP gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 85.5 153 14733729 (5), 17206721 (5), 10515819 (4), 8704115 (4) (see all 73)
    lipoteichoic acid 68.2 32 12594207 (4), 16928689 (4), 9925653 (2), 11828371 (2) (see all 8)
    polymyxin b 61.2 7 15279607 (1), 11181108 (1), 12920053 (1), 18354232 (1) (see all 6)
    phospholipid 49.4 42 8985160 (2), 9103463 (2), 10768924 (2), 15784577 (2) (see all 26)
    monophosphoryl lipid a 41.9 3 17254389 (1), 7515085 (1)
    peptidoglycan 35.7 4 15294986 (1), 8051139 (1), 11705912 (1)
    lipid 32.3 35 7536794 (3), 16303759 (3), 9441745 (2), 10607703 (2) (see all 20)
    fibrinogen 26.5 18 19330269 (5), 10607703 (3), 9715256 (1), 18198263 (1) (see all 8)
    diethylcarbamazine 23.6 2 10915090 (1), 10717762 (1)
    calcitriol 22.4 3 1380063 (1), 7517989 (1)



    LBP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LBP gene: 
    NM_004139.4  

    Unigene Cluster for LBP:

    Lipopolysaccharide binding protein
    Hs.154078  [show with all ESTs]
    Unigene Representative Sequence: NM_004139
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000217407(uc002xic.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    1 qRT-PCR Assays for microRNA that regulate LBP:
    hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmidLBP 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): LBP (NM_203346)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LBP
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      QuantiFast Probe-based Assays in human, mouse, rat LBP

    Additional mRNA sequence: 

    AF105067.1 AK313625.1 AY344471.1 BC022256.1 M35533.1 

    2 DOTS entries:

    DT.110781  DT.100776620 

    Selected AceView cDNA sequences (see all 59):

    NM_004139 CR606921 CR592006 R29149 CB163947 CA489550 AV658726 BG618841 
    CB164493 BX406391 BX325221 CR613938 CR621941 M35533 CB164055 CB162798 
    BG565573 BQ669569 BX423833 T29116 BX108847 BI763303 CB161731 BG618594 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    LBP expression in normal human tissues (normalized intensities)      LBP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCTGGAAC
    LBP Expression
    About this image


    LBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipocytes Visceral White Adipose
             Visceral White Adipose
     
     Liver (Hepatobiliary System)
             Liver Lobule
    LBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154078

    UniProtKB/Swiss-Prot: LBP_HUMAN, P18428
    Tissue specificity: Detected in blood serum (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LBP: 
              Innate & Adaptive Immune Responses in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LBP gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lbp1 , 5 lipopolysaccharide binding protein1, 5 76.66(n)1
    69.15(a)1
      2 (78.72 cM)5
    168031  NM_008489.21  NP_032515.21 
     1583064935 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    45(a)
    1 → many
    20(10686637-10694283)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    1 → many
    GL343572.1(380262-388004)


    ENSEMBL Gene Tree for LBP (if available)
    TreeFam Gene Tree for LBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LBP gene
    PLTP2  BPIFC2  BPI2  
    1 SIMAP similar gene for LBP using alignment to 2 protein entries:     LBP_HUMAN (see all proteins):
    BPI

    LBP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LBP (see all 1021)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57441971,2
    C,F,H--36972845(+) CACCTG/TGGGTT 1 -- us2k112Minor allele frequency- T:0.02NA EU NS EA WA 726
    rs17806161,2
    C,F,A,H--36972942(+) CAATTC/TCTGCT 1 -- us2k119Minor allele frequency- T:0.41NA EU NS EA CSA WA 976
    rs1381654841,2
    --36972960(+) GCAAGC/GATCTC 1 -- us2k10--------
    rs732850681,2
    C,F--36972985(+) TCAGCC/TGTGCC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1431514831,2
    --36973086(+) ACGGTA/GCAGAG 1 -- us2k10--------
    rs1482117461,2
    --36973277(+) ATTACC/TTTTTG 1 -- us2k10--------
    rs1412169871,2
    --36973308(+) TTCGTA/GGGCAT 1 -- us2k10--------
    rs60250231,2
    C--36973310(+) cgtggA/Gcatat 1 -- us2k10--------
    rs1890305731,2
    --36973372(+) GAAAGC/TGCAAA 1 -- us2k10--------
    rs57441981,2
    C,F,H--36973471(+) CAGAAC/TTCACA 1 -- us2k112Minor allele frequency- T:0.01NA EU NS EA 596

    HapMap Linkage Disequilibrium report for LBP (36974759 - 37005665 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666106CNV Deletion23128226
    esv2540422CNV Insertion19546169
    nsv817893CNV Gain17921354
    esv35121CNV Gain17911159
    essv13086CNV CNV17122850
    dgv1327e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): LBP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LBP
    DNA2.0 Custom Variant and Variant Library Synthesis for LBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151990    OMIM disorders: --

    Selected diseases for LBP (see all 58):    About MalaCards
    infective endocarditis    bacteremia    pneumothorax    spontaneous pneumothorax
    primary spontaneous pneumothorax    endocarditis    obstructive jaundice    alcoholic hepatitis
    sepsis    disseminated intravascular coagulation    filariasis    hepatopulmonary syndrome
    preterm premature rupture of the membranes    septic shock    meningitis    liver disease
    mastitis    acute pancreatitis    peritonitis    acute graft versus host disease


    LBP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for LBP gene (see all 47)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    response acute phase 73.8 38 8668165 (2), 8588345 (2), 8021509 (2), 9442384 (2) (see all 18)
    shock septic 73.5 18 14624690 (3), 7963737 (2), 11739189 (2), 1284855 (1) (see all 11)
    gram-negative bacterial infections 70.7 4 8432532 (1), 9380744 (1), 7678583 (1), 7504510 (1)
    sepsis 68.6 125 11373419 (5), 18552695 (5), 19707138 (5), 16512634 (5) (see all 39)
    systemic inflammatory response syndrome 67.5 15 18552695 (2), 16569262 (1), 16875458 (1), 7538550 (1) (see all 9)
    necrosis 58.7 42 7685250 (2), 1281827 (1), 7543094 (1), 8975896 (1) (see all 37)
    nasal epithelium 48.1 2 12427544 (1)
    bacterial infections 42.5 17 9360683 (2), 16407966 (2), 17259880 (2), 17328727 (1) (see all 10)
    inflammation 42.3 25 17601541 (2), 7562749 (2), 8418776 (2), 11605136 (1) (see all 17)
    hepatitis alcoholic 41 2 10803780 (1)

    Genetic Association Database (GAD): LBP
    Human Genome Epidemiology (HuGE) Navigator: LBP (40 documents)

    Export disorders for LBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LBP gene, integrated from 10 sources (see all 451):
    (articles sorted by number of sources associating them with LBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation. (PubMed id 18056482)1, 4, 9 Chien J.W....Clark J.G. (Blood 2008)
    2. The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved. (PubMed id 9240454)1, 2, 9 Hubacek J.A.... Schmitz G. (Biochem. Biophys. Res. Commun. 1997)
    3. Lipopolysaccharide-binding protein (LBP) gene polymorphisms: rapid genotyping by real-time PCR and association with infective endocarditis. (PubMed id 19560454)1, 4, 9 Vollmer T....Dreier J. (Clin. Biochem. 2009)
    4. Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins. (PubMed id 9441745)1, 2, 9 Kirschning C.J.... Schumann R.R. (Genomics 1997)
    5. Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS- mediated cell activation. (PubMed id 7517398)1, 2, 9 Wilde C.G.... Scott R.W. (J. Biol. Chem. 1994)
    6. A common haplotype of the LBP gene predisposes to severe sepsis. (PubMed id 19707138)1, 4, 9 Flores C....Villar J. (Crit. Care Med. 2009)
    7. Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. (PubMed id 12521224)1, 4, 9 Hubacek J.A....Poledne R. (Clin. Chem. Lab. Med. 2002)
    8. Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. (PubMed id 11373419)1, 4, 9 Hubacek J.A....Schmitz G. (Crit. Care Med. 2001)
    9. Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PubMed id 19200604)1, 4, 9 Verstraelen H....Temmerman M. (J. Reprod. Immunol. 2009)
    10. Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis. (PubMed id 12615620)1, 4, 9 Barber R.C. and O'Keefe G.E. (Am. J. Respir. Crit. Care Med. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3929 HGNC: 6517 AceView: LBP Ensembl:ENSG00000129988 euGenes: HUgn3929
    ECgene: LBP Kegg: 3929 H-InvDB: LBP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LBP gene:
    Search GeneIP for patents involving LBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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