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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LBP Gene

protein-coding GIFtS: 66
GCID: GC20P036974

lipopolysaccharide binding protein

(Previous name: lipopolysaccharide-binding protein )

Explore 60 diseases affiliated with
LBP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lipopolysaccharide Binding Protein¹ ²
BPIFD2¹ ²
Lipopolysaccharide-Binding Protein¹ ²
BPI Fold Containing Family D, Member 2²
LPS-Binding Protein²

External Ids:	HGNC: 6517¹	Entrez Gene: 3929²	Ensembl: ENSG00000129988⁷	OMIM: 151990⁵	UniProtKB: P18428³

Export aliases for LBP gene to outside databases

Previous GC identifers: GC20P036703 GC20P037613 GC20P037660 GC20P036408 GC20P033709

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LBP:

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial

infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together

with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14

receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the

encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from

circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma

cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: LBP_HUMAN, P18428

Function: Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer

membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with

LPS

Gene Wiki entry for LBP (Lipopolysaccharide-binding protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LBP gene promoter:
HOXA9B HOXA9 HNF-4alpha2 Meis-1b HNF-4alpha1 CREB deltaCREB TGIF Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LBP promoter sequence

Search SABiosciences Chromatin IP Primers for LBP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LBP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q11.23

LBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LBP gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P036974: view genomic region (about GC identifiers)

Start:	36,974,759 bp from pter	End:	37,005,665 bp from pter
Size:	30,907 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LBP_HUMAN, P18428 (See protein sequence)

Recommended Name: Lipopolysaccharide-binding protein precursor

Size: 481 amino acids; 53384 Da

Subunit: When bound to LPS, interacts (via C-terminus) with soluble CD14

Subcellular location: Secreted

Secondary accessions: B2R938 O43438 Q92672 Q9H403 Q9UD66

Explore the universe of human proteins at neXtProt for LBP: NX_P18428

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18428

LBP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004130.2

ENSEMBL proteins:

ENSP00000217407

Reactome Protein details: P18428
Human Recombinant Protein Products:

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	Uscn Proteins for LBP

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	ISS	2477488

LBP for ontologies About GeneDecksing

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Assay Products for LBP:

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	Enzo Life Sciences assays for LBP
	Uscn ELISAs and CLIAs for LBP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LBP for domains About GeneDecksing

4 InterPro domains/families:

IPR017942 Lipid-bd_serum_glycop_N

IPR017943 Bactericidal_perm-incr_a/b_dom

IPR001124 Lipid-bd_serum_glycop_C

IPR017954 Lipid-bd_serum_glycop_CS

Graphical View of Domain Structure for InterPro Entry P18428

ProtoNet protein and cluster: P18428

1 Blocks protein family: IPB001124 Lipid-binding serum glycoprotein

UniProtKB/Swiss-Prot: LBP_HUMAN, P18428

Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LBP_HUMAN, P18428

Function: Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer

membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with

LPS

Genatlas biochemistry entry for LBP:

lipopolysaccharide,acute-phase protein specifically binding to the lipid A moiety of liposaceharide (LPS,endotoxin)

from the cell wall of Gram- bacteria binding protein,and directing it to the CD14 receptor mainly expressed by

phagocytes

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LBP
		1 QIAGEN miScript miRNA Assays for microRNA that regulate LBP:
		hsa-miR-1224-5p
		SwitchGear 3'UTR luciferase reporter plasmid: LBP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LBP (see all 7) OriGene shRNA RFP: LBP OriGene siRNA: LBP
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LBP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): LBP (NM_203346)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LBP
		Search LifeMap BioReagents cell lines for LBP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LBP

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001530	lipopolysaccharide binding	ISS	2477488
GO:0005102	receptor binding	ISS	2477488
GO:0005515	protein binding	IPI	--
GO:0008289	lipid binding	--	--
GO:0043498	cell surface binding	ISS	2477488

LBP for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for LBP: Lbp^tm1Buru Lbp^tm1Jack
     3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lbp):

homeostasis/metabolism

immune system

liver/biliary system

LBP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Toll Comparative Pathway

	Immune response_MIF in innate immunity response	0.46			iNOS Signaling	0.34
	Immune response MIF in innate immunity response	0.46

Immune response_Bacterial infections in normal airways

Immune response_Bacterial infections in normal airways

1.00

Bacterial infections in CF airways

0.78

Immune System

Immune System

1.00

Innate Immune System

0.46

Transcription NF-kB signaling pathway

Transcription NF-kB signaling pathway

1.00

Transcription_NF-kB signaling pathway

0.85

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

1.00

Immune response_TLR signaling pathways

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for LBP

	Transcription NF-kB signaling pathway
	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Immune response MIF in innate immunity response

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LBP

	iNOS Signaling
	LPS Stimulated MAPK Signaling
	Toll-Like Receptors Pathway

5/7 GeneGo (Thomson Reuters) Pathways for LBP (see all 7)

	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Transcription NF-kB signaling pathway
	Cytokine production by Th17 cells in CF (Mouse model)
	Immune response TLR signaling pathways

2 BioSystems Pathways for LBP

	Toll-like receptor signaling pathway
	IL6-mediated signaling events

5 Reactome Pathways for LBP

	Toll Like Receptor 4 (TLR4) Cascade
	Toll-Like Receptors Cascades
	Transfer of LPS from LBP carrier to CD14
	Immune System
	Innate Immune System

2 Kegg Pathways (Kegg details for LBP):

	Toll-like receptor signaling pathway
	Tuberculosis

LBP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LBP

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/24 Interacting proteins for LBP (P18428^{1, 3} ENSP00000217407⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD14	P08571³, ENSP00000304236⁴	I2D: score=3 STRING: ENSP00000304236
IRF6	O14896³, ENSP00000355988⁴	I2D: score=1 STRING: ENSP00000355988
RPS21	P63220³, ENSP00000324438⁴	I2D: score=2 STRING: ENSP00000324438
APOA1	P02647³, ENSP00000236850⁴	I2D: score=3 STRING: ENSP00000236850
CFHR1	Q03591³, ENSP00000314299⁴	I2D: score=3 STRING: ENSP00000314299

About this table

Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002232	leukocyte chemotaxis involved in inflammatory response	IEA	--
GO:0002281	macrophage activation involved in immune response	ISS	2402637
GO:0006869	lipid transport	--	--
GO:0006953	acute-phase response	ISS	2477488
GO:0006968	cellular defense response	ISS	2402637

LBP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LBP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LBP

10/519 HMDB Compounds for LBP (see all 519) About this table

Compound	Synonyms	CAS #	PubMed Ids
3-Dehydrosphinganine	1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)	16105-69-4	--
3-O-Sulfogalactosylceramide (d18:1/12:0)	Sulfatide (d18:1/12:0) (see all 13)	852100-88-0	--
3-O-Sulfogalactosylceramide (d18:1/14:0)	Sulfatide (d18:1/14:0) (see all 13)	--	--
3-O-Sulfogalactosylceramide (d18:1/16:0)	Sulfatide (d18:1/16:0) (see all 13)	862509-48-6	--
3-O-Sulfogalactosylceramide (d18:1/18:0)	Sulfatide (d18:1/18:0) (see all 13)	244215-65-4	--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))	Sulfatide (d18:1/18:1(9Z)) (see all 13)	--	--
3-O-Sulfogalactosylceramide (d18:1/20:0)	Sulfatide (d18:1/20:0) (see all 13)	265096-81-9	--
3-O-Sulfogalactosylceramide (d18:1/22:0)	Sulfatide (d18:1/22:0) (see all 13)	265096-83-1	--
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))	Sulfatide (d18:1/24:1(15Z)) (see all 13)	151057-28-2	--

10/38 Novoseek chemical compound relationships for LBP gene (see all 38) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
endotoxin	85.5	153	14733729 (5), 17206721 (5), 10515819 (4), 8704115 (4) (see all 73)
lipoteichoic acid	68.2	32	12594207 (4), 16928689 (4), 9925653 (2), 11828371 (2) (see all 8)
polymyxin b	61.2	7	15279607 (1), 11181108 (1), 12920053 (1), 18354232 (1) (see all 6)
phospholipid	49.4	42	8985160 (2), 9103463 (2), 10768924 (2), 15784577 (2) (see all 26)
monophosphoryl lipid a	41.9	3	17254389 (1), 7515085 (1)
peptidoglycan	35.7	4	15294986 (1), 8051139 (1), 11705912 (1)
lipid	32.3	35	7536794 (3), 16303759 (3), 9441745 (2), 10607703 (2) (see all 20)
fibrinogen	26.5	18	19330269 (5), 10607703 (3), 9715256 (1), 18198263 (1) (see all 8)
diethylcarbamazine	23.6	2	10915090 (1), 10717762 (1)
calcitriol	22.4	3	1380063 (1), 7517989 (1)

Search CenterWatch for drugs/clinical trials and news about LBP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LBP gene:

NM_004139.3

Unigene Cluster for LBP:

Lipopolysaccharide binding protein

Hs.154078 [show with all ESTs]

Unigene Representative Sequence: NM_004139

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000217407(uc002xic.1)

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		hsa-miR-1224-5p
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		GenScript: all cDNA clones in your preferred vector (see all 2): LBP (NM_203346)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LBP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LBP

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LBP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LBP

Additional cDNA sequence:

AF105067.1 AK313625.1 AY344471.1 BC022256.1 M35533.1

2 DOTS entries:

DT.110781 DT.100776620

24/59 AceView cDNA sequences (see all 59):

CR621941 CB163947 CR592006 BG618841 NM_004139 BX406391 CA489550 AV658726

R29149 CR613938 CB164493 BX325221 CR606921 BC022256 T29116 BX431764

BG567007 BV206109 BX411404 CB161731 BQ028088 BX427893 AL557972 BG565573

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCTGGAAC

About this image

LBP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Adipose

Visceral White Adipose

Adipose

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LBP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LBP

SOURCE GeneReport for Unigene cluster: Hs.154078

SABiosciences Expression via Pathway-Focused PCR Arrays including LBP:

Innate & Adaptive Immune Responses in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Antibacterial Response in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LBP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for LBP gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BPI⁶	Uncharacterized protein	47(a)	1 → many	20(10293927-10300309)
lizard (Anolis carolinensis)	Reptilia	BPI⁶	--	37(a)	1 → many	GL343572.1(380262-388004)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G20270¹	lipid-binding serum glycoprotein-like protein	39.06(n) 24.13(a)		821571 NM_001203010.1 NP_001189939.1
rice (Oryza sativa)	Liliopsida	Os06g0309200¹	hypothetical protein	40.73(n) 24.69(a)		4340853 NM_001064014.1 NP_001057479.1

ENSEMBL Gene Tree for LBP (if available)
TreeFam Gene Tree for LBP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LBP gene

BPIFB4² BPIFB6² BPIFB2² PLTP² BPIFB3² BPIFC² BPI²

1 SIMAP similar gene for LBP using alignment to 2 protein entries: LBP_HUMAN (see all proteins):

BPI

LBP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5744197^1,2	C,F,H,	--	36972845(+)	`CACCTG/TGGGTT`	1	--	us2k¹		12		NA EU NS EA WA	726
rs1780616^1,2	C,F,A,H,	--	36972942(+)	`CAATTC/TCTGCT`	1	--	us2k¹		19		NA EU NS EA CSA WA	976
rs138165484^1,2		--	36972960(+)	`GCAAGC/GATCTC`	1	--	us2k¹		0	--	--	--	--
rs73285068^1,2	C,	--	36972985(+)	`TCAGCC/TGTGCC`	1	--	us2k¹		1		WA	2
rs143151483^1,2		--	36973086(+)	`ACGGTA/GCAGAG`	1	--	us2k¹		0	--	--	--	--
rs148211746^1,2		--	36973277(+)	`ATTACC/TTTTTG`	1	--	us2k¹		0	--	--	--	--
rs141216987^1,2		--	36973308(+)	`TTCGTA/GGGCAT`	1	--	us2k¹		0	--	--	--	--
rs189030573^1,2		--	36973372(+)	`GAAAGC/TGCAAA`	1	--	us2k¹		0	--	--	--	--
rs5744198^1,2	C,F,H,	--	36973471(+)	`CAGAAC/TTCACA`	1	--	us2k¹		12		NA EU NS EA	596
rs5744199^1,2	C,F,	--	36973672(+)	`CCAAGC/AGGGAG`	1	--	us2k¹		10		NA EU	298

HapMap Linkage Disequilibrium report for LBP (36974759 - 37005665 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for LBP
4 CNVs: 9824 8884 3217 4101
1 Indel: 102965
Human Gene Mutation Database (HGMD): LBP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LBP

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LBP for disorders           About GeneDecksing

OMIM gene information: 151990    OMIM disorders: --

20/60 diseases for LBP (see all 60):    About MalaCards

disseminated intravascular coagulation spontaneous pneumothorax proliferative diabetic retinopathy pediatric crohns disease

chronic obstructive pulmonary disease pneumothorax diabetic retinopathy haemophilus influenzae

myocardial infarction obstructive jaundice liver disease cystic fibrosis

infective endocarditis inflammatory bowel disease jaundice rheumatoid arthritis

meningitis allergic asthma endocarditis neutropenia

10/47 Novoseek disease relationships for LBP gene (see all 47) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
response acute phase	73.8	38	8668165 (2), 8588345 (2), 8021509 (2), 9442384 (2) (see all 18)
shock septic	73.5	18	14624690 (3), 7963737 (2), 11739189 (2), 1284855 (1) (see all 11)
gram-negative bacterial infections	70.7	4	8432532 (1), 9380744 (1), 7678583 (1), 7504510 (1)
sepsis	68.6	125	11373419 (5), 18552695 (5), 19707138 (5), 16512634 (5) (see all 39)
systemic inflammatory response syndrome	67.5	15	18552695 (2), 16569262 (1), 16875458 (1), 7538550 (1) (see all 9)
necrosis	58.7	42	7685250 (2), 1281827 (1), 7543094 (1), 8975896 (1) (see all 37)
nasal epithelium	48.1	2	12427544 (1)
bacterial infections	42.5	17	9360683 (2), 16407966 (2), 17259880 (2), 17328727 (1) (see all 10)
inflammation	42.3	25	17601541 (2), 7562749 (2), 8418776 (2), 11605136 (1) (see all 17)
hepatitis alcoholic	41	2	10803780 (1)

Genetic Association Database (GAD): LBP
Human Genome Epidemiology (HuGE) Navigator: LBP (40 documents)

Export disorders for LBP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LBP gene, integrated from 9 sources (see all 442):
(articles sorted by number of sources associating them with LBP)

Utopia: connect your pdf to the dynamic
world of online information

The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved. (PubMed id 9240454)^{1, 2, 9} Hubacek J.A.... Schmitz G. (1997)
Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins. (PubMed id 9441745)^{1, 2, 9} Kirschning C.J.... Schumann R.R. (1997)
Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS- mediated cell activation. (PubMed id 7517398)^{1, 2, 9} Wilde C.G.... Scott R.W. (1994)
Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. (PubMed id 12521224)^{1, 4, 9} Hubacek J.A....Poledne R. (2002)
Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. (PubMed id 11373419)^{1, 4, 9} Hubacek J.A....Schmitz G. (2001)
Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis. (PubMed id 12615620)^{1, 4, 9} Barber R.C. and O'Keefe G.E. (2003)
The BPI/LBP family of proteins: a structural analysis of conserved regions. (PubMed id 9568897)^{1, 2, 9} Beamer L.J.... Eisenberg D. (1998)
The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20. (PubMed id 8432532)^{1, 3, 9} Gray P.W....Shows T.B. (1993)
Structure and function of lipopolysaccharide binding protein. (PubMed id 2402637)^{1, 2, 9} Schumann R.R.... Ulevitch R.J. (1990)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3929	HGNC: 6517	AceView: LBP	Ensembl:ENSG00000129988	euGenes: HUgn3929
ECgene: LBP	Kegg: 3929	H-InvDB: LBP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LBP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LBP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LBP gene:
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GeneCards and IP:
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lipopolysaccharide binding protein

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