Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LBH Gene

Aliases for LBH Gene

  • Limb Bud And Heart Development 2 3
  • HLBH 3 4
  • Limb Bud And Heart Development Homolog (Mouse) 2
  • Limb Bud And Heart Development Homolog 3

External Ids for LBH Gene

Previous GeneCards Identifiers for LBH Gene

  • GC02P030371
  • GC02P030561
  • GC02P030428
  • GC02P030366
  • GC02P030454
  • GC02P030192

Summaries for LBH Gene

GeneCards Summary for LBH Gene

LBH (Limb Bud And Heart Development) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LBH Gene

  • Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.

Gene Wiki entry for LBH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LBH Gene

Genomics for LBH Gene

Regulatory Elements for LBH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LBH Gene

Chromosome:
2
Start:
30,231,531 bp from pter
End:
30,323,730 bp from pter
Size:
92,200 bases
Orientation:
Plus strand

Genomic View for LBH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LBH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LBH Gene

Proteins for LBH Gene

  • Protein details for LBH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53QV2-LBH_HUMAN
    Recommended name:
    Protein LBH
    Protein Accession:
    Q53QV2
    Secondary Accessions:
    • B2RBC2
    • Q9H0Q1

    Protein attributes for LBH Gene

    Size:
    105 amino acids
    Molecular mass:
    12217 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LBH Gene

Proteomics data for LBH Gene at MOPED

Post-translational modifications for LBH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LBH Gene

No data available for DME Specific Peptides for LBH Gene

Domains & Families for LBH Gene

Protein Domains for LBH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LBH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53QV2

UniProtKB/Swiss-Prot:

LBH_HUMAN :
  • Belongs to the LBH family.
Family:
  • Belongs to the LBH family.
genes like me logo Genes that share domains with LBH: view

No data available for Gene Families for LBH Gene

Function for LBH Gene

Molecular function for LBH Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
genes like me logo Genes that share phenotypes with LBH: view

Animal Models for LBH Gene

MGI Knock Outs for LBH:
  • Lbh tm1.2Kbri

Animal Model Products

miRNA for LBH Gene

miRTarBase miRNAs that target LBH

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LBH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for LBH Gene

Localization for LBH Gene

Subcellular locations from UniProtKB/Swiss-Prot for LBH Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LBH Gene COMPARTMENTS Subcellular localization image for LBH gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for LBH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LBH: view

Pathways & Interactions for LBH Gene

SuperPathways for LBH Gene

No Data Available

Interacting Proteins for LBH Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378733%0d%0a9606.ENSP00000261454%0d%0a
Selected Interacting proteins: ENSP00000378733 for LBH Gene via STRING

Symbol External ID(s) Details
PROX1

Gene Ontology (GO) - Biological Process for LBH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0010468 regulation of gene expression IMP 21810271
GO:0030193 regulation of blood coagulation IMP 21810271
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with LBH: view

No data available for Pathways by source and SIGNOR curated interactions for LBH Gene

Drugs & Compounds for LBH Gene

(3) Drugs for LBH Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1792
Prednisone Approved Pharma 1208
Panobinostat Pharma Histone deacetylase (HDAC)inhibitors 126
genes like me logo Genes that share compounds with LBH: view

Transcripts for LBH Gene

Unigene Clusters for LBH Gene

Limb bud and heart development:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LBH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LBH Gene

No ASD Table

Relevant External Links for LBH Gene

GeneLoc Exon Structure for
LBH
ECgene alternative splicing isoforms for
LBH

Expression for LBH Gene

mRNA expression in normal human tissues for LBH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LBH Gene

This gene is overexpressed in Fetal Brain (18.7), Peripheral blood mononuclear cells (11.4), CD4 Tcells (10.5), Blymphocyte (7.2), and CD8 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LBH Gene



SOURCE GeneReport for Unigene cluster for LBH Gene Hs.567598

mRNA Expression by UniProt/SwissProt for LBH Gene

Q53QV2-LBH_HUMAN
Tissue specificity: Highly expressed in heart, and expressed at low levels in placenta, lung, skeletal muscle, kidney and liver.
genes like me logo Genes that share expression patterns with LBH: view

Protein tissue co-expression partners for LBH Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LBH Gene

Orthologs for LBH Gene

This gene was present in the common ancestor of chordates.

Orthologs for LBH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LBH 35
  • 89.84 (n)
  • 93.33 (a)
LBH 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LBH 35
  • 87.94 (n)
  • 92.38 (a)
LBH 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lbh 35
  • 89.21 (n)
  • 90.48 (a)
Lbh 16
Lbh 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LBH 35
  • 99.68 (n)
  • 99.05 (a)
LBH 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lbh 35
  • 90.79 (n)
  • 91.43 (a)
oppossum
(Monodelphis domestica)
Mammalia LBH 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LBH 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves LBH 35
  • 78.73 (n)
  • 78.1 (a)
LBH 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LBH 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lbh 35
  • 79.08 (n)
  • 80.39 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
zgc:66337 35
  • 73.11 (n)
  • 62.5 (a)
LBH 36
  • 57 (a)
OneToOne
Species with no ortholog for LBH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LBH Gene

ENSEMBL:
Gene Tree for LBH (if available)
TreeFam:
Gene Tree for LBH (if available)

Paralogs for LBH Gene

(1) SIMAP similar genes for LBH Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LBH: view

No data available for Paralogs for LBH Gene

Variants for LBH Gene

Sequence variations from dbSNP and Humsavar for LBH Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9558 -- 30,259,051(+) AGTCC(A/G)CCGAG utr-variant-3-prime
rs872260 -- 30,249,402(-) TCCTA(C/T)GATGG intron-variant
rs906864 -- 30,259,233(-) TGCCC(C/T)GGCAT utr-variant-3-prime
rs906865 -- 30,255,307(+) CTCGG(C/T)ACATG intron-variant
rs906866 -- 30,255,319(+) ACGTC(C/T)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LBH Gene

Variant ID Type Subtype PubMed ID
dgv1163e1 CNV Complex 17122850
esv34904 CNV Gain 17911159
nsv2662 CNV Loss 18451855

Variation tolerance for LBH Gene

Residual Variation Intolerance Score: 46.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LBH Gene

HapMap Linkage Disequilibrium report
LBH
Human Gene Mutation Database (HGMD)
LBH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LBH Gene

Disorders for LBH Gene

Relevant External Links for LBH

Genetic Association Database (GAD)
LBH
Human Genome Epidemiology (HuGE) Navigator
LBH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LBH
genes like me logo Genes that share disorders with LBH: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LBH Gene

Publications for LBH Gene

  1. A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway. (PMID: 17390236) Ai J. … Wu X. (Mol. Biol. Rep. 2008) 23 67
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 67
  3. Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development. (PMID: 11336496) Briegel K.J. … Joyner A.L. (Dev. Biol. 2001) 2 67
  4. The Rheumatoid Arthritis Risk Gene LBH Regulates Growth in Fibroblast-like Synoviocytes. (PMID: 25707478) Ekwall A.K. … Firestein G.S. ( 2015) 67
  5. Genetics of rheumatoid arthritis contributes to biology and drug discovery. (PMID: 24390342) Okada Y. … Plenge R.M. (Nature 2013) 67

Products for LBH Gene

Sources for LBH Gene

Back to Top

Content