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Aliases for LBH Gene

Aliases for LBH Gene

  • Limb Bud And Heart Development 2 3 5
  • HLBH 3 4
  • Limb Bud And Heart Development Homolog (Mouse) 2
  • Limb Bud And Heart Development Homolog 3
  • Protein LBH 3

External Ids for LBH Gene

Previous GeneCards Identifiers for LBH Gene

  • GC02P030371
  • GC02P030561
  • GC02P030428
  • GC02P030366
  • GC02P030454
  • GC02P030192

Summaries for LBH Gene

GeneCards Summary for LBH Gene

LBH (Limb Bud And Heart Development) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LBH Gene

  • Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.

Gene Wiki entry for LBH Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LBH Gene

Genomics for LBH Gene

Regulatory Elements for LBH Gene

Enhancers for LBH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G030286 1.6 Ensembl ENCODE dbSUPER 20.4 +57.7 57661 4.4 HNRNPUL1 FOXA2 PKNOX1 CREB3L1 ARNT ZNF766 FOS REST TBX21 ZNF592 LBH ENSG00000207187 LOC102723594 GC02P030258
GH02G030407 1.4 FANTOM5 Ensembl ENCODE 18.5 +179.4 179372 7.1 NFXL1 RAD21 FOS IKZF2 ZNF263 CBFB CEBPB ZEB2 NR2F2 NFIC LBH ENSG00000207187 LCLAT1 LINC01936 YPEL5 ENSG00000280154
GH02G030250 1.6 Ensembl ENCODE dbSUPER 11.9 +24.0 23973 10.3 HDGF PKNOX1 ARNT SIN3A ZNF766 CBX5 FOS KLF13 REST TBX21 LBH GC02P030258
GH02G030299 1.1 Ensembl ENCODE dbSUPER 16.6 +69.7 69736 3.0 ESRRA JUND BHLHE40 POU5F1 SIN3A FOS NR2F2 LBH ENSG00000207187 LOC102723594 LINC01936
GH02G030264 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +34.9 34862 4.4 CHAMP1 ZFHX2 ZNF316 NCOR1 EGR1 FOS MAFK EGR2 NR2F1 HLF ENSG00000207187 LBH YPEL5 GC02P030258 LOC102723594
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LBH on UCSC Golden Path with GeneCards custom track

Promoters for LBH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114787 769 3401 FOXA2 PKNOX1 SIN3A ZNF2 ZNF143 ZNF207 ZNF263 SP3 REST SMARCA4

Genomic Location for LBH Gene

30,231,531 bp from pter
30,323,730 bp from pter
92,200 bases
Plus strand

Genomic View for LBH Gene

Genes around LBH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LBH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LBH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LBH Gene

Proteins for LBH Gene

  • Protein details for LBH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein LBH
    Protein Accession:
    Secondary Accessions:
    • B2RBC2
    • Q9H0Q1

    Protein attributes for LBH Gene

    105 amino acids
    Molecular mass:
    12217 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LBH Gene

Post-translational modifications for LBH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LBH Gene

No data available for DME Specific Peptides for LBH Gene

Domains & Families for LBH Gene

Protein Domains for LBH Gene


Suggested Antigen Peptide Sequences for LBH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LBH family.
  • Belongs to the LBH family.
genes like me logo Genes that share domains with LBH: view

No data available for Gene Families for LBH Gene

Function for LBH Gene

Molecular function for LBH Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
genes like me logo Genes that share phenotypes with LBH: view

Animal Models for LBH Gene

MGI Knock Outs for LBH:
  • Lbh tm1.2Kbri

Animal Model Products

CRISPR Products

miRNA for LBH Gene

miRTarBase miRNAs that target LBH

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LBH Gene

Localization for LBH Gene

Subcellular locations from UniProtKB/Swiss-Prot for LBH Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LBH gene
Compartment Confidence
nucleus 4
extracellular 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LBH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LBH: view

Pathways & Interactions for LBH Gene

No Data Available

Interacting Proteins for LBH Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000378733 Q53QV2-LBH_HUMAN for LBH Gene via STRING IID

Gene Ontology (GO) - Biological Process for LBH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0010468 regulation of gene expression IMP 21810271
GO:0030193 regulation of blood coagulation IMP 21810271
genes like me logo Genes that share ontologies with LBH: view

No data available for Pathways by source and SIGNOR curated interactions for LBH Gene

Drugs & Compounds for LBH Gene

(11) Drugs for LBH Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1967
Panobinostat Approved, Investigational Pharma Histone deacetylase (HDAC)inhibitors 135
Prednisone Approved, Vet_approved Pharma 1398
Anti-Inflammatory Agents Pharma 10729
Antimitotic Agents Pharma 5657
genes like me logo Genes that share compounds with LBH: view

Transcripts for LBH Gene

Unigene Clusters for LBH Gene

Limb bud and heart development:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LBH Gene

No ASD Table

Relevant External Links for LBH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LBH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LBH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LBH Gene

This gene is overexpressed in Fetal Brain (18.7), Peripheral blood mononuclear cells (11.4), CD4 Tcells (10.5), Blymphocyte (7.2), and CD8 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LBH Gene

Protein tissue co-expression partners for LBH Gene

NURSA nuclear receptor signaling pathways regulating expression of LBH Gene:


SOURCE GeneReport for Unigene cluster for LBH Gene:


mRNA Expression by UniProt/SwissProt for LBH Gene:

Tissue specificity: Highly expressed in heart, and expressed at low levels in placenta, lung, skeletal muscle, kidney and liver.

Evidence on tissue expression from TISSUES for LBH Gene

  • Nervous system(4.8)
  • Kidney(4.3)
  • Lung(2.5)
  • Heart(2.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with LBH: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LBH Gene

Orthologs for LBH Gene

This gene was present in the common ancestor of chordates.

Orthologs for LBH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LBH 34 35
  • 99.68 (n)
(Rattus norvegicus)
Mammalia Lbh 34
  • 90.79 (n)
(Bos Taurus)
Mammalia LBH 34 35
  • 89.84 (n)
(Mus musculus)
Mammalia Lbh 34 16 35
  • 89.21 (n)
(Canis familiaris)
Mammalia LBH 34 35
  • 87.94 (n)
(Ornithorhynchus anatinus)
Mammalia LBH 35
  • 84 (a)
(Monodelphis domestica)
Mammalia LBH 35
  • 59 (a)
(Gallus gallus)
Aves LBH 34 35
  • 78.73 (n)
(Anolis carolinensis)
Reptilia LBH 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lbh 34
  • 79.08 (n)
(Danio rerio)
Actinopterygii zgc:66337 34
  • 73.11 (n)
LBH 35
  • 57 (a)
-- 34
Species where no ortholog for LBH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LBH Gene

Gene Tree for LBH (if available)
Gene Tree for LBH (if available)

Paralogs for LBH Gene

(1) SIMAP similar genes for LBH Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LBH: view

No data available for Paralogs for LBH Gene

Variants for LBH Gene

Sequence variations from dbSNP and Humsavar for LBH Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000034126 -- 30,233,416(+) AACCA(C/T)ACAAT intron-variant
rs1000130248 -- 30,235,633(+) GTCTA(A/G)GTTGA intron-variant
rs1000172708 -- 30,258,542(+) GTGGG(C/T)GTGGT utr-variant-3-prime
rs1000347231 -- 30,252,991(+) ACTTT(G/T)GGGAA intron-variant
rs1000383568 -- 30,253,280(+) AGATA(A/G)GATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LBH Gene

Variant ID Type Subtype PubMed ID
esv2759035 CNV gain 17122850
esv34904 CNV gain 17911159
esv3590194 CNV gain 21293372
nsv2662 CNV deletion 18451855

Variation tolerance for LBH Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LBH Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LBH Gene

Disorders for LBH Gene

Relevant External Links for LBH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LBH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LBH Gene

Publications for LBH Gene

  1. A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway. (PMID: 17390236) Ai J. … Wu X. (Mol. Biol. Rep. 2008) 3 4 22 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  3. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PMID: 21810271) Antoni G. … Tregouet D.A. (BMC Med. Genet. 2011) 3 46 64
  4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for LBH Gene

Sources for LBH Gene

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