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Aliases for LAYN Gene

Aliases for LAYN Gene

External Ids for LAYN Gene

Previous GeneCards Identifiers for LAYN Gene

  • GC11P110917
  • GC11P111411
  • GC11P107335

Summaries for LAYN Gene

GeneCards Summary for LAYN Gene

LAYN (Layilin) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is CHODL.

UniProtKB/Swiss-Prot for LAYN Gene

  • Receptor for hyaluronate.

Additional gene information for LAYN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAYN Gene

Genomics for LAYN Gene

Regulatory Elements for LAYN Gene

Enhancers for LAYN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H111559 1.2 Ensembl ENCODE dbSUPER 19 +22.6 22568 3.9 SOX5 SOX13 GATAD2A SAP130 TEAD1 HLF NR2F1 HMG20A PPARG RARA SIK2 LAYN ENSG00000254980 C11orf88 BTG4 MIR34C MIR34B POU2AF1 LOC644277 PPP2R1B
GH11H111357 1.6 FANTOM5 ENCODE dbSUPER 9.6 -174.1 -174081 15.7 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 YBX1 YY1 SLC30A9 COLCA2 COLCA1 LAYN BTG4 C11orf88 MIR34B MIR34C POU2AF1 MIR4491 RNU2-60P
GH11H111793 1.4 FANTOM5 ENCODE dbSUPER 10.3 +256.2 256178 3.7 ATF1 INSM2 FEZF1 YY1 ZNF316 LCORL CTBP1 ZNF366 POLR2A ZNF600 PPP2R1B ALG9 LAYN BCO2 SIK2 ENSG00000254990 ALG9-IT1
GH11H111764 1.3 ENCODE dbSUPER 9.7 +227.0 227031 3.3 ZNF493 ARID4B SIN3A YY1 ZNF121 GLIS2 RUNX3 ZNF202 SP3 ZC3H11A ALG9 SIK2 PPP2R1B ENSG00000255334 PIH1D2 NKAPD1 LAYN BTG4 MIR34B MIR34C
GH11H111693 1.3 Ensembl ENCODE dbSUPER 9.3 +155.7 155731 2.7 PKNOX1 INSM2 KLF17 FEZF1 HIC1 FOS ATF7 MAFK IKZF2 CREM PPP2R1B SIK2 LAYN RN7SKP273 PIR48599
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LAYN on UCSC Golden Path with GeneCards custom track

Genomic Locations for LAYN Gene

Genomic Locations for LAYN Gene
chr11:111,538,985-111,561,745
(GRCh38/hg38)
Size:
22,761 bases
Orientation:
Plus strand
chr11:111,411,005-111,432,264
(GRCh37/hg19)

Genomic View for LAYN Gene

Genes around LAYN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAYN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAYN Gene

Proteins for LAYN Gene

  • Protein details for LAYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX15-LAYN_HUMAN
    Recommended name:
    Layilin
    Protein Accession:
    Q6UX15
    Secondary Accessions:
    • A6NJB0
    • B4DJU0
    • Q8TAY8
    • Q96NC5
    • Q96NF3

    Protein attributes for LAYN Gene

    Size:
    382 amino acids
    Molecular mass:
    43108 Da
    Quaternary structure:
    • Interacts with NF2, RDX and TLN1.

    Alternative splice isoforms for LAYN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAYN Gene

Post-translational modifications for LAYN Gene

  • Glycosylation at posLast=117117 and posLast=195195
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LAYN Gene

Domains & Families for LAYN Gene

Gene Families for LAYN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LAYN Gene

Graphical View of Domain Structure for InterPro Entry

Q6UX15

UniProtKB/Swiss-Prot:

LAYN_HUMAN :
  • The C-terminal domain interacts with the N-terminal domain of RDX.
Domain:
  • The C-terminal domain interacts with the N-terminal domain of RDX.
genes like me logo Genes that share domains with LAYN: view

Function for LAYN Gene

Molecular function for LAYN Gene

UniProtKB/Swiss-Prot Function:
Receptor for hyaluronate.

Phenotypes From GWAS Catalog for LAYN Gene

Gene Ontology (GO) - Molecular Function for LAYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005540 hyaluronic acid binding IDA 11294894
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LAYN: view
genes like me logo Genes that share phenotypes with LAYN: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAYN Gene

Localization for LAYN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAYN Gene

Membrane; Single-pass type I membrane protein. Note=Colocalizes with TLN1 at the membrane ruffles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAYN gene
Compartment Confidence
extracellular 3
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LAYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005925 NOT focal adhesion IDA,ISS --
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LAYN: view

Pathways & Interactions for LAYN Gene

No Data Available

Interacting Proteins for LAYN Gene

Gene Ontology (GO) - Biological Process for LAYN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LAYN Gene

Drugs & Compounds for LAYN Gene

(1) Drugs for LAYN Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target, binder 503
genes like me logo Genes that share compounds with LAYN: view

Transcripts for LAYN Gene

Unigene Clusters for LAYN Gene

Layilin:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAYN Gene

No ASD Table

Relevant External Links for LAYN Gene

GeneLoc Exon Structure for
LAYN
ECgene alternative splicing isoforms for
LAYN

Expression for LAYN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAYN Gene

Protein differential expression in normal tissues from HIPED for LAYN Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LAYN Gene



Protein tissue co-expression partners for LAYN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LAYN Gene:

LAYN

SOURCE GeneReport for Unigene cluster for LAYN Gene:

Hs.503831

Evidence on tissue expression from TISSUES for LAYN Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with LAYN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAYN Gene

Orthologs for LAYN Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAYN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAYN 33 34
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia LAYN 33 34
  • 89.04 (n)
mouse
(Mus musculus)
Mammalia Layn 33 16 34
  • 86.02 (n)
cow
(Bos Taurus)
Mammalia LAYN 33 34
  • 85.52 (n)
rat
(Rattus norvegicus)
Mammalia Layn 33
  • 83.24 (n)
oppossum
(Monodelphis domestica)
Mammalia LAYN 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAYN 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAYN 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia layn 33
  • 62.57 (n)
zebrafish
(Danio rerio)
Actinopterygii layna 33 34
  • 59.57 (n)
laynb 34
  • 35 (a)
OneToMany
Species where no ortholog for LAYN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAYN Gene

ENSEMBL:
Gene Tree for LAYN (if available)
TreeFam:
Gene Tree for LAYN (if available)

Paralogs for LAYN Gene

Paralogs for LAYN Gene

(1) SIMAP similar genes for LAYN Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LAYN: view

Variants for LAYN Gene

Sequence variations from dbSNP and Humsavar for LAYN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000114802 -- 111,551,774(+) AACAT(C/G)ATGTG intron-variant
rs1000154255 -- 111,543,899(+) TGAAA(C/T)AGATT intron-variant
rs1000166849 -- 111,551,470(+) ACACT(G/T)CCTGT intron-variant
rs1000230443 -- 111,550,471(+) CTTCC(C/T)TAAAG intron-variant
rs1000341042 -- 111,545,083(+) TTTAC(C/T)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAYN Gene

Variant ID Type Subtype PubMed ID
nsv472629 CNV novel sequence insertion 20440878

Variation tolerance for LAYN Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 60.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAYN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAYN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAYN Gene

Disorders for LAYN Gene

Relevant External Links for LAYN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAYN

No disorders were found for LAYN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAYN Gene

Publications for LAYN Gene

  1. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. (PMID: 15913605) Bono P … Hynes RO (Experimental cell research 2005) 2 3 22 60
  2. Layilin, a novel integral membrane protein, is a hyaluronan receptor. (PMID: 11294894) Bono P … Hynes RO (Molecular biology of the cell 2001) 3 4 22 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60

Products for LAYN Gene

Sources for LAYN Gene

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