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LAYN Gene

protein-coding   GIFtS: 50

GC11P110917
layilin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ30977 1, 2
FLJ31092 1, 2
layilin 2
External Ids
HGNC: 294711
Entrez Gene: 1439032
UniProtKB: Q6UX153
Ensembl: ENSG000002043817
Search outside databases for aliases for LAYN gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: LAYN_HUMAN, Q6UX15
Function: Receptor for hyaluronate

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LAYN gene  

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

LAYN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P110917:     (about GC identifiers)

Start:
110,916,443 bp from pter
End:
110,936,998 bp from pter
Size:
20,556 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_033899.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LAYN_HUMAN, Q6UX15 (See protein sequence)
Recommended Name: Layilin precursor  
Size: 382 amino acids; 43108 Da
Subunit: Interacts with NF2, RDX and TLN1 (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Note=Colocalizes
with TLN1 at the membrane ruffles (By similarity)
Secondary accessions: A6NJB0 Q8TAY8 Q96NC5 Q96NF3
Alternative splicing: 2 isoforms:  Q6UX15-1   Q6UX15-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_849156.1  

    ENSEMBL proteins: 
    ENSP00000364764 ENSP00000364765 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for LAYN (Layilin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LAYN)
    Human Recombinant Proteins from Abnova (LAYN)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726 ruffle ISS--
    GO:0005925NOT focal adhesion ISS--
    GO:0009986 cell surface ISS--
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for LAYN: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LAYN
    R&D Systems Antibodies for LAYN (Layilin)
    Antibodies from Abcam (LAYN), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (LAYN)
    Novus Biologicals Antibody for LAYN

    Assays for LAYN: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    R&D Systems ELISAs for LAYN (Layilin)         (see all)
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin


       GeneDecks  LAYN for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6UX15

    ProtoNet protein and cluster: Q6UX15

    UniProtKB/Swiss-Prot: LAYN_HUMAN, Q6UX15
    Domain: The C-terminal domain interacts with the N-terminal domain of RDX (By similarity)
    Similarity: Contains 1 C-type lectin domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LAYN)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178834

                  Applied Biosystems Silencer® siRNAs for LAYN

                  Sigma-Aldrich siRNA for LAYN  
                         Sigma-Aldrich shRNA for LAYN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for LAYN
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_178834
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_178834
                                     untagged cDNA clones in CMV expression vector (see all 2): AK096925 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_178834

    UniProtKB/Swiss-Prot: LAYN_HUMAN, Q6UX15
    Function: Receptor for hyaluronate

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding ISS9786953
    GO:0005529 sugar binding IEA--
    GO:0005540 hyaluronic acid binding IDA11294894
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  LAYN 


    4 Interacting proteins for LAYN (ENSP000003647653) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RDXENSP000003428303STRING (score=.93)
    TLN1ENSP000003160293STRING (score=.925)
    TLN2ENSP000003034763STRING (score=.925)
    NF2ENSP000003356523STRING (score=.923)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LAYN

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LAYN)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178834

                  Sigma-Aldrich siRNA for LAYN  
                         Sigma-Aldrich shRNA for LAYN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_178834  

    REFSEQ mRNAs for LAYN gene: 

    NM_178834.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_178834  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_178834
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_178834
                                     untagged cDNA clones in CMV expression vector (see all 2): AK096925 

    Additional cDNA sequence: 

    AK055539.1 AK055654.1 AK096925.1 AK293317.1 AK296231.1 AK298165.1 AY358554.1 BC025407.1 
    CR590889.1 CR608344.1 CR612367.1 

    5 DOTS entries:

    DT.205286  DT.97781865  DT.91738974  DT.100763648  DT.75101480 

    24/71 AceView cDNA sequences (see all 71 ):

    CR590889 AI765714 BF591215 CR608344 AK055539 BM988423 CR612367 AL691759 
    BM783174 AL691760 NM_178834 CA414955 BG548740 BM006769 AW192166 BG705209 
    BQ918229 AW593251 BQ931495 BX377019 BU727378 AL521520 BQ926685 AI597761 

    highest scoring ESTs for LAYN:

    AA384314 AI049628 AI073853 AI147915 AI420998 AI572772 AI597761 AI765714 AK055539 AK055654 

    Unigene Cluster for LAYN:

    Layilin
    Hs.503831  [show with all ESTs]
    Unigene Representative Sequence: AK096925


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000375614  ENST00000375615  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LAYN expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LAYN

    1 / 2 / 3

    3 probe-sets matching LAYN gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    76750_at2, 3 U95-E 2 1.00 0.97 1.00 1.00 AA447940 0.60 1.00 0.82 1

    228080_at2, 3 U133-B 1 1.00 1.00 -- -- BE856341 0.80 1.00 0.91 1

    228080_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  LAYN for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGGTCCCCAC

    SOURCE GeneReport for Unigene cluster: Hs.503831
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for LAYN gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LAYN1   -- layilin 88.89(n)
    86.56(a)
    489411  XM_546529.2  XP_546529.2 
    chimpanzee
    (Pan troglodytes)
    LAYN1   -- layilin 99.38(n)
    98.93(a)
    451539  XM_508749.2  XP_508749.2 
    cow
    (Bos taurus)
    LAYN1   -- layilin 85.25(n)
    82.04(a)
    527089  XM_605478.3  XP_605478.3 
    rat
    (Rattus norvegicus)
    Layn1   -- layilin 84.02(n)
    81.47(a)
    500996  XM_576410.2  XP_576410.2 
    mouse
    (Mus musculus)
    Layn1, 5 95
    layilin1, 5 85.45(n)1
    82.74(a)1
    2448641  XM_146887.71  XP_146887.71 
     AC1198315  AK0869305  (see all 7)
    About this table        Species with no ortholog for LAYN

    ENSEMBL Gene Tree for LAYN
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for LAYN gene
    CHODL2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/83 NCBI SNPs in LAYN are shown (see all 83 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 42)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs5680381,2
    A,C,F,H,O110937371(+) TCCCTT/GATACT 1 -- ng314Minor allele frequency- G:0.32EU EA WA 418
    rs5422751,2
    A,C,F,H,O110936824(+) ACAGGT/CTGGCC 1 -- ut319Minor allele frequency- C:0.31MN EU EA WA NA 964
    rs6147251,2
    A,C,F,H110916043(-) AGGAAC/ATGATT 1 -- ng515Minor allele frequency- A:0.11MN EU EA WA 598
    rs118277181,2
    C,F,H110919944(+) TTGAGG/AAAGCC 1 K/E mis1 ese35Minor allele frequency- A:0.02EU EA WA NA 496
    rs6346791,2
    A,C,F,H110925574(+) GAGCCG/ATCCTG 1 P/P syn18Minor allele frequency- A:0.03MN EU EA WA NA 728
    rs6822391,2
    A,C,F,H,O110930315(+) TTAGTT/CTTTGT 1 -- int116Minor allele frequency- C:0.34NS NA EU EA WA 1088
    rs5870101,2
    A,C,F,H,O110930868(+) CCCTTA/CCCCTT 1 -- int1 trp37Minor allele frequency- N:0.00EA NA EU 496
    rs6790321,2
    A,C,F,H,O110928496(+) CTGGGT/GTGTGC 1 -- int19Minor allele frequency- G:0.27EU EA WA NA 732
    rs5182941,2
    A,C,F,H,O110929926(-) AAGTGA/TCTTGA 1 -- int17Minor allele frequency- T:0.34EU EA WA NA 550
    rs6637631,2
    A,C,F,H110927427(+) CATGCT/CCAGAA 1 -- int14Minor allele frequency- C:0.33EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for LAYN (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/12 PubMed articles for LAYN gene (see all 12 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 143903 HGNC: 29471 AceView: LOC143903 Ensembl:ENSG00000204381 euGenes: HUgn143903
    ECgene: LAYN H-InvDB: LAYN
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LAYN:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LAYN-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LAYN Antibodies for LAYN
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LAYN Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Search OriGene for LAYN
     Search Tocris compounds for LAYN




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for LAYN

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