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Aliases & Descriptions for LAYN
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ30977 1, 2 | | FLJ31092 1, 2 | | layilin 2 |
| | |
| | Search outside databases for aliases for LAYN gene |
Summaries for LAYN(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: LAYN_HUMAN, Q6UX15Function: Receptor for hyaluronate |
Genomic Location for LAYN
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAYN gene 
Entrez Gene cytogenetic band: 11q23.1 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q23.1LAYN Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P110917:
(about GC identifiers)
Start:
|
110,916,443 bp from pter |
End:
|
110,936,998 bp from pter |
Size:
|
20,556 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033899.7
| Proteins for LAYN
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAYN_HUMAN, Q6UX15 (See
protein sequence)Recommended Name: Layilin precursor Size: 382 amino acids; 43108 Da
Subunit: Interacts with NF2, RDX and TLN1 (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Note=Colocalizes with TLN1 at the membrane ruffles (By similarity)
Secondary accessions: A6NJB0 Q8TAY8 Q96NC5 Q96NF3Alternative splicing: 2 isoforms: Q6UX15-1 Q6UX15-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_849156.1
ENSEMBL proteins: ENSP00000364764 ENSP00000364765
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LAYN: Assays for LAYN: | Protein
Domains/ Families for LAYN(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6UX15
ProtoNet protein and cluster: Q6UX15 UniProtKB/Swiss-Prot: LAYN_HUMAN, Q6UX15Domain: The C-terminal domain interacts with the N-terminal domain of RDX (By similarity)Similarity: Contains 1 C-type lectin domain | Gene Function for LAYN
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178834
Applied Biosystems Silencer® siRNAs for LAYN
Sigma-Aldrich siRNA for LAYN  Sigma-Aldrich shRNA for LAYN  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178834                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_178834                                  untagged cDNA clones in CMV expression vector (see all 2): AK096925 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_178834
UniProtKB/Swiss-Prot: LAYN_HUMAN, Q6UX15Function: Receptor for hyaluronate3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for LAYN
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for LAYN 
4 Interacting proteins for LAYN (ENSP000003647653) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for LAYN(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAYN
|
Transcripts for LAYN(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178834
Sigma-Aldrich siRNA for LAYN  Sigma-Aldrich shRNA for LAYN  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_178834 REFSEQ mRNAs for LAYN gene: NM_178834.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_178834               OriGene GFP tagged cDNA clone in CMV expression vector: NM_178834                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_178834                                  untagged cDNA clones in CMV expression vector (see all 2): AK096925  Additional cDNA sequence: AK055539.1 AK055654.1 AK096925.1 AK293317.1 AK296231.1 AK298165.1 AY358554.1 BC025407.1 CR590889.1 CR608344.1 CR612367.1 5 DOTS entries: DT.205286 DT.97781865 DT.91738974 DT.100763648 DT.75101480 24/71 AceView cDNA sequences (see all 71
):CR590889 AI765714 BF591215 CR608344 AK055539 BM988423 CR612367 AL691759 BM783174 AL691760 NM_178834 CA414955 BG548740 BM006769 AW192166 BG705209 BQ918229 AW593251 BQ931495 BX377019 BU727378 AL521520 BQ926685 AI597761
highest scoring ESTs for LAYN:AA384314 AI049628 AI073853 AI147915 AI420998 AI572772 AI597761 AI765714 AK055539 AK055654 Unigene Cluster for LAYN: Layilin Hs.503831 [show with all ESTs]Unigene Representative Sequence: AK096925
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000375614
ENST00000375615
|
Expression for LAYN
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAYN expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAYN
1 / 2 / 3 3 probe-sets matching LAYN gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGGTCCCCAC
SOURCE GeneReport for Unigene cluster: Hs.503831
|
Orthologs for LAYN
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAYN gene from 5/6 species (see all 6
)
About this table Species with no ortholog for LAYN
ENSEMBL Gene Tree for LAYN | Paralogs for LAYN(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LAYN gene
- CHODL2
|
SNPs/Variants for LAYN(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAYN (up to first 250kb)
|
Disorders & Mutations for LAYN
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for LAYN(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAYN (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for LAYN gene (see all 12
):- Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. (PubMed id 15913605)1, 2, 3 Bono P....Hynes R.O. (2005)
- Layilin, a novel integral membrane protein, is a hyaluronan receptor. (PubMed id 11294894)1, 3, 4 Bono P.... Hynes R.O. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. (PubMed id 9786953)1, 3 Borowsky M.L. and Hynes R.O. (1998)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)4 Taylor T.D....Sakaki Y. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Down-regulation of layilin, a novel hyaluronan receptor, via RNA interference, inhibits invasion and lymphatic metastasis of human lung A549 cells. (PubMed id 17822380)1 Chen Z....An J. (2008)
- Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain. (PubMed id 18638481)1 Wegener K.L....Barsukov I.L. (2008)
|
Search for LAYN
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAYN
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAYN
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAYN(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LAYN(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAYN:

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Incremental update: 13 Oct 2009
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