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LAX1 Gene

protein-coding   GIFtS: 49

GC01P202000
lymphocyte transmembrane adaptor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for LAX1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ20340 1, 2
LAX 1, 2, 3
OTTHUMP00000034094 2
Descriptions
LAT-like membrane associated protein 2
Linker for activation of X cells 2, 3
Membrane-associated adapter protein LAX 3
lymphocyte transmembrane adaptor 1 2
External Ids
HGNC: 260051
Entrez Gene: 549002
UniProtKB: Q8IWV13
Ensembl: ENSG000001221887
Search outside databases for aliases for LAX1 gene

Previous GC identifer: GC01P200467

Summaries
for LAX1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LAX1_HUMAN, Q8IWV1
Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR
(B-cell antigen receptor)-mediated signaling in B-cells

Genomic Location
for LAX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LAX1 gene  

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

LAX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P202000:     (about GC identifiers)

Start:
 202,000,960 bp from pter
End:
 202,012,123 bp from pter
Size:
 11,164 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  

Proteins
for LAX1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: LAX1_HUMAN, Q8IWV1 (See protein sequence)
Recommended Name: Lymphocyte transmembrane adapter 1  
Size: 398 amino acids; 44085 Da
Subunit: When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2
Subcellular location: Cell membrane; Single-pass type III membrane protein
Secondary accessions: Q6NSZ6 Q9NXB4
Alternative splicing: 2 isoforms:  Q8IWV1-1   Q8IWV1-2   

Post-translational modifications:

  • Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the
    recruitment of GRB2, PIK3R1 and GRAP21
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001129662.1  NP_060243.2  


    ENSEMBL proteins: 
    ENSP00000356186 ENSP00000356184 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LAX1)
    Human Recombinant Proteins from Abnova (LAX1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA18029348
    GO:0005794 Golgi apparatus IDA18029348
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IDA12359715
    GO:0045121NOT membrane raft IDA12359715
    About this table

    Antibodies for LAX1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LAX1
    R&D Systems Antibodies for LAX1
    Antibodies from Abcam (LAX1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (LAX1)
    Novus Biologicals Antibodies for LAX1

    Assays for LAX1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for LAX1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IWV1

    Gene Function
    for LAX1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (LAX1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017773

                  Applied Biosystems Silencer® siRNAs for LAX1

                  Sigma-Aldrich siRNA for LAX1  
                         Sigma-Aldrich shRNA Panels and shRNA for LAX1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for LAX1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136190
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136190
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001136190 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017773

    UniProtKB/Swiss-Prot: LAX1_HUMAN, Q8IWV1
    Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR
    (B-cell antigen receptor)-mediated signaling in B-cells
    Induction: Up-regulated in T-cells following TCR engagement

    2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lax1):

    hematopoietic systemimmune system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI12359715
    GO:0019901 protein kinase binding IDA12359715
    GO:0042169 SH2 domain binding IDA12359715
    About this table

    Pathways & Interactions
    for LAX1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for LAX1 (ENSP000003561863) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELNENSP000003518073STRING (score=.855)
    GRB2ENSP000003390073STRING (score=.769)
    --ENSP000002537073STRING (score=.726)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188 inactivation of MAPK activity IMP12359715
    GO:0006955 immune response IDA12359715
    GO:0007242 intracellular signaling cascade IDA12359715
    GO:0042113 B cell activation IDA12359715
    GO:0050868 negative regulation of T cell activation IDA12359715
    About this table

    Drugs & Compounds
    for LAX1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LAX1

    Transcripts
    for LAX1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (LAX1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017773

                  Sigma-Aldrich siRNA for LAX1  
                         Sigma-Aldrich shRNA Panels and shRNA for LAX1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001136190  NM_017773  

    REFSEQ mRNAs for LAX1 gene (2 alternative transcripts): 

    NM_001136190.1   NM_017773.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001136190  NM_017773  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136190
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136190
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001136190 

    Additional cDNA sequence: 

    AK000347.1 AK225331.1 AK301076.1 AK301421.1 AY090784.1 BC069650.1 BC089408.1 

    3 DOTS entries:

    DT.99938350  DT.40202035  DT.100781400 

    15 AceView cDNA sequences:

    BC069650 AY090784 CF136957 BE245297 AI051656 AK000347 AA353976 AW505023 
    NM_017773 BP361408 AW576547 BX476784 CD689523 CD693832 BF879415 

    highest scoring ESTs for LAX1:

    AI051656 AK000347 AY090784 BC069650 BC089408 BX476784 CF136957 NM_017773 AA353976 AK225331 

    Unigene Cluster for LAX1:

    Lymphocyte transmembrane adaptor 1
    Hs.272794  [show with all ESTs]
    Unigene Representative Sequence: NM_017773


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LAX1

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                    -                                 
    SP2:                                                      
    SP3:              -     -                                 

    About this scheme

    ECgene alternative splicing isoforms for LAX1

    2 Ensembl transcripts including schematic representations:
    ENST00000367217  ENST00000367215  

    Expression
    for LAX1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LAX1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LAX1

    1 / 2 / 3

    2 probe-sets matching LAX1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		207734_at2, 3 U133-A 1 1.00 1.00 -- -- NM_017773 0.60 1.00 0.82 1

    		207734_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTGGTGTGCG

    SOURCE GeneReport for Unigene cluster: Hs.272794

    UniProtKB/Swiss-Prot: LAX1_HUMAN, Q8IWV1
    Tissue specificity: Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in
    several B-, T-, NK and monocyte cell lines

    Orthologs
    for LAX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for LAX1 gene from 4 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 LAX11   -- lymphocyte transmembrane adaptor 1 99.5(n)
    99.5(a)    		 741370  XM_001156566.1  XP_001156566.1 
    cow
    (Bos taurus)    		 LAX11   -- lymphocyte transmembrane adaptor 1 75.57(n)
    63.87(a)    		 540424  NM_001015674.1  NP_001015674.1 
    rat
    (Rattus norvegicus)    		 Lax11   -- lymphocyte transmembrane adaptor 1 71.93(n)
    55.35(a)    		 498232  NM_001017491.1  NP_001017491.1 
    mouse
    (Mus musculus)    		 Lax11, 5 15
    		 lymphocyte transmembrane adaptor 11, 5 71.64(n)1
    54.4(a)1    		 2407541  NM_172842.21  NP_766430.21 
     AA8819185  AK0408345  (see all 10)
    About this table        Species with no ortholog for LAX1

    ENSEMBL Gene Tree for LAX1

    Paralogs
    for LAX1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for LAX1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/130 NCBI SNPs in LAX1 are shown (see all 130 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 53)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs66808861,2
    		A,C,F,H202000449(+) GTAGTA/GCCCAG 1 -- ng514Minor allele frequency- G:0.32EU EA WA 412
    rs66858901,2
    		A,C,F,H202011330(+) ttgacC/Gcaagt 2 -- ut31 ese34Minor allele frequency- G:0.03EU EA WA 420
    rs115796021,2
    		C,F,H202000202(+) TTTCCG/AGAGAT 1 -- ng514Minor allele frequency- A:0.18EU EA WA 404
    rs112403911,2
    		A,C,F202000854(+) CCCTGT/GGCTTC 1 -- ng514Minor allele frequency- G:0.26NA EA 362
    --
    rs109004751,2
    		A,C202011807(+) CTCACA/GCCCGT 2 -- ut31 ese30--------
    --
    rs109004691,2
    		A,C201999076(+) gtggcA/Ggtgca 1 -- ng510--------
    rs112404181,2
    		F,H202011953(+) CCCTGT/ACTCTC 2 -- ut31 ese34Minor allele frequency- A:0.01EU EA WA 420
    rs23658691,2
    		H202012223(-) agattC/Aatttg 1 -- ng314Minor allele frequency- A:0.00EU EA WA 420
    rs120751581,2
    		H202011526(+) atataG/Aacata 2 -- ut314Minor allele frequency- A:0.00EU EA WA 402
    --
    rs49511981,2
    		A202010881(+) TGCAGC/TGGCTC 2 -- ut310--------
    About this table

    HapMap Linkage Disequilibrium images for LAX1 (up to first 250kb)

    Disorders & Mutations
    for LAX1

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for LAX1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for LAX1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		9 PubMed articles for LAX1 gene:

    Search for LAX1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LAX1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 54900 HGNC: 26005 AceView: LAX Ensembl:ENSG00000122188 euGenes: HUgn54900
    ECgene: LAX1 H-InvDB: LAX1

    Other Databases showing LAX1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing LAX1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for LAX1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for LAX1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LAX1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LAX1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LAX1 Antibodies for LAX1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LAX1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
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     Search OriGene for LAX1
     Search Tocris compounds for LAX1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for LAX1

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