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Aliases for LATS2 Gene

Aliases for LATS2 Gene

  • Large Tumor Suppressor Kinase 2 2 3
  • LATS (Large Tumor Suppressor, Drosophila) Homolog 2 2 3
  • Kinase Phosphorylated During Mitosis Protein 3 4
  • Serine/Threonine-Protein Kinase Kpm 3 4
  • Large Tumor Suppressor Homolog 2 3 4
  • Warts-Like Kinase 3 4
  • EC 2.7.11.1 4 63
  • KPM 3 4
  • LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) 2
  • LATS, Large Tumor Suppressor, Homolog 2 3
  • Serine/Threonine-Protein Kinase LATS2 3
  • Serine/Threonine Kinase KPM 3
  • EC 2.7.11 63

External Ids for LATS2 Gene

Previous GeneCards Identifiers for LATS2 Gene

  • GC13M019528
  • GC13M015527
  • GC13M020478
  • GC13M019346
  • GC13M020446
  • GC13M021547
  • GC13M002350

Summaries for LATS2 Gene

Entrez Gene Summary for LATS2 Gene

  • This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for LATS2 Gene

LATS2 (Large Tumor Suppressor Kinase 2) is a Protein Coding gene. Diseases associated with LATS2 include intracranial abscess. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is STK38L.

UniProtKB/Swiss-Prot for LATS2 Gene

  • Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

Gene Wiki entry for LATS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LATS2 Gene

Genomics for LATS2 Gene

Regulatory Elements for LATS2 Gene

Genomic Location for LATS2 Gene

Start:
20,973,032 bp from pter
End:
21,061,583 bp from pter
Size:
88,552 bases
Orientation:
Minus strand

Genomic View for LATS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LATS2 Gene

Proteins for LATS2 Gene

  • Protein details for LATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRM7-LATS2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LATS2
    Protein Accession:
    Q9NRM7
    Secondary Accessions:
    • B1AM47
    • Q9P2X1

    Protein attributes for LATS2 Gene

    Size:
    1088 amino acids
    Molecular mass:
    120136 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP and AJUBA. Interacts with SNAI1.
    SequenceCaution:
    • Sequence=BAA92381.1; Type=Frameshift; Positions=512, 526; Evidence={ECO:0000305};

neXtProt entry for LATS2 Gene

Proteomics data for LATS2 Gene at MOPED

Selected DME Specific Peptides for LATS2 Gene

Post-translational modifications for LATS2 Gene

  • Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activated by STK3/MST2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LATS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for LATS2 Gene

Suggested Antigen Peptide Sequences for LATS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRM7

UniProtKB/Swiss-Prot:

LATS2_HUMAN :
  • Q9NRM7
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with LATS2: view

Function for LATS2 Gene

Molecular function for LATS2 Gene

GENATLAS Biochemistry: LATS Drosophila large tumor suppressor,homolog 2,same as Drosophila loss of the warts
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

Enzyme Numbers (IUBMB) for LATS2 Gene

Gene Ontology (GO) - Molecular Function for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16413547
GO:0005524 ATP binding IDA 10871863
genes like me logo Genes that share ontologies with LATS2: view
genes like me logo Genes that share phenotypes with LATS2: view

Animal Models for LATS2 Gene

MGI Knock Outs for LATS2:

miRNA for LATS2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for LATS2 Gene

Localization for LATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LATS2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LATS2 Gene COMPARTMENTS Subcellular localization image for LATS2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 12853976
GO:0005634 nucleus NAS 10673337
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LATS2: view

Pathways for LATS2 Gene

genes like me logo Genes that share pathways with LATS2: view

Pathways by source for LATS2 Gene

1 Cell Signaling Technology pathway for LATS2 Gene
1 BioSystems pathway for LATS2 Gene
2 Reactome pathways for LATS2 Gene
1 KEGG pathway for LATS2 Gene

Gene Ontology (GO) - Biological Process for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 12853976
GO:0006468 protein phosphorylation IDA 10871863
GO:0007067 mitotic nuclear division IEA --
GO:0009755 hormone-mediated signaling pathway IDA 15131260
GO:0030216 keratinocyte differentiation IEA --
genes like me logo Genes that share ontologies with LATS2: view

Compounds for LATS2 Gene

(3) HMDB Compounds for LATS2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(2) Novoseek inferred chemical compound relationships for LATS2 Gene

Compound -log(P) Hits PubMed IDs
threonine 25.9 2
serine 10.8 2
genes like me logo Genes that share compounds with LATS2: view

Transcripts for LATS2 Gene

mRNA/cDNA for LATS2 Gene

Unigene Clusters for LATS2 Gene

LATS, large tumor suppressor, homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LATS2 Gene

No ASD Table

Relevant External Links for LATS2 Gene

GeneLoc Exon Structure for
LATS2
ECgene alternative splicing isoforms for
LATS2

Expression for LATS2 Gene

mRNA expression in normal human tissues for LATS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LATS2 Gene

SOURCE GeneReport for Unigene cluster for LATS2 Gene Hs.78960

mRNA Expression by UniProt/SwissProt for LATS2 Gene

Q9NRM7-LATS2_HUMAN
Tissue specificity: Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
genes like me logo Genes that share expressions with LATS2: view

No data available for mRNA differential expression in normal tissues for LATS2 Gene

Orthologs for LATS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LATS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LATS2 35
  • 99.17 (n)
  • 99.45 (a)
LATS2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LATS2 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LATS2 35
  • 85.84 (n)
  • 89.38 (a)
LATS2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lats2 35
  • 82.32 (n)
  • 86.4 (a)
Lats2 16
Lats2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LATS2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LATS2 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lats2 35
  • 82.19 (n)
  • 86.89 (a)
chicken
(Gallus gallus)
Aves LATS2 35
  • 72.65 (n)
  • 79.16 (a)
LATS2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LATS2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lats2 35
  • 69.35 (n)
  • 73.95 (a)
zebrafish
(Danio rerio)
Actinopterygii lats2 35
  • 64.23 (n)
  • 68.95 (a)
lats2 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wts 36
  • 40 (a)
OneToMany
wts 37
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea wts-1 36
  • 34 (a)
OneToMany
T20F10.1 37
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for LATS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LATS2 Gene

ENSEMBL:
Gene Tree for LATS2 (if available)
TreeFam:
Gene Tree for LATS2 (if available)

Paralogs for LATS2 Gene

Selected SIMAP similar genes for LATS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LATS2: view

Variants for LATS2 Gene

Sequence variations from dbSNP and Humsavar for LATS2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs478243 -- 21,004,478(+) TCAAA(C/T)TTTAA intron-variant
rs481485 -- 21,025,763(-) CCTCC(A/G)TGCAG intron-variant
rs492809 -- 20,986,257(+) accaa(A/T)cccat intron-variant
rs498032 -- 20,997,234(+) TTACA(C/T)ATGAA intron-variant
rs501811 -- 20,984,125(-) GAAAC(A/G)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LATS2 Gene

Variant ID Type Subtype PubMed ID
nsv9059 CNV Gain 18304495
esv2747072 CNV Deletion 23290073
nsv64790 CNV Loss 16902084
esv1336723 CNV Insertion 17803354

Relevant External Links for LATS2 Gene

HapMap Linkage Disequilibrium report
LATS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LATS2 Gene

Disorders for LATS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for LATS2 Gene including...

Search for LATS2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for LATS2 Gene

(4) Novoseek inferred disease relationships for LATS2 Gene

Disease -log(P) Hits PubMed IDs
warts 79.6 9
tumors 38.3 28
cancer 16.8 2
breast cancer 9.46 7

Relevant External Links for LATS2

Genetic Association Database (GAD)
LATS2
Human Genome Epidemiology (HuGE) Navigator
LATS2
genes like me logo Genes that share disorders with LATS2: view

No data available for UniProtKB/Swiss-Prot for LATS2 Gene

Publications for LATS2 Gene

  1. Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. (PMID: 10673337) Yabuta N. … Nojima H. (Genomics 2000) 2 3 4 23
  2. Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. (PMID: 10871863) Hori T. … Uchiyama T. (Oncogene 2000) 3 4 23
  3. Lats2, a putative tumor suppressor, inhibits G1/S transition. (PMID: 12853976) Li Y. … Tao W. (Oncogene 2003) 3 4 23
  4. The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. (PMID: 15131260) Powzaniuk M. … Bai C. (Mol. Endocrinol. 2004) 3 4 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for LATS2 Gene

Sources for LATS2 Gene

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