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Aliases for LATS2 Gene

Aliases for LATS2 Gene

  • Large Tumor Suppressor Kinase 2 2 3 5
  • LATS (Large Tumor Suppressor, Drosophila) Homolog 2 2 3
  • Kinase Phosphorylated During Mitosis Protein 3 4
  • Serine/Threonine-Protein Kinase Kpm 3 4
  • Large Tumor Suppressor Homolog 2 3 4
  • Warts-Like Kinase 3 4
  • EC 2.7.11.1 4 63
  • KPM 3 4
  • LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) 2
  • LATS, Large Tumor Suppressor, Homolog 2 3
  • Serine/Threonine Kinase KPM 3
  • EC 2.7.11 63

External Ids for LATS2 Gene

Previous GeneCards Identifiers for LATS2 Gene

  • GC13M019528
  • GC13M015527
  • GC13M020478
  • GC13M019346
  • GC13M020446
  • GC13M021547
  • GC13M002350

Summaries for LATS2 Gene

Entrez Gene Summary for LATS2 Gene

  • This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for LATS2 Gene

LATS2 (Large Tumor Suppressor Kinase 2) is a Protein Coding gene. Diseases associated with LATS2 include intracranial abscess and malignant peritoneal mesothelioma. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPA.

UniProtKB/Swiss-Prot for LATS2 Gene

  • Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

Gene Wiki entry for LATS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LATS2 Gene

Genomics for LATS2 Gene

Regulatory Elements for LATS2 Gene

Promoters for LATS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LATS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LATS2 Gene

Chromosome:
13
Start:
20,973,032 bp from pter
End:
21,061,583 bp from pter
Size:
88,552 bases
Orientation:
Minus strand

Genomic View for LATS2 Gene

Genes around LATS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LATS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LATS2 Gene

Proteins for LATS2 Gene

  • Protein details for LATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRM7-LATS2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LATS2
    Protein Accession:
    Q9NRM7
    Secondary Accessions:
    • B1AM47
    • Q9P2X1

    Protein attributes for LATS2 Gene

    Size:
    1088 amino acids
    Molecular mass:
    120136 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP and AJUBA. Interacts with SNAI1.
    SequenceCaution:
    • Sequence=BAA92381.1; Type=Frameshift; Positions=512, 526; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LATS2 Gene

neXtProt entry for LATS2 Gene

Proteomics data for LATS2 Gene at MOPED

Selected DME Specific Peptides for LATS2 Gene

Post-translational modifications for LATS2 Gene

  • Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activated by STK3/MST2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LATS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LATS2 (LATS2)

Domains & Families for LATS2 Gene

Suggested Antigen Peptide Sequences for LATS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRM7

UniProtKB/Swiss-Prot:

LATS2_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with LATS2: view

Function for LATS2 Gene

Molecular function for LATS2 Gene

GENATLAS Biochemistry:
LATS Drosophila large tumor suppressor,homolog 2,same as Drosophila loss of the warts
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

Enzyme Numbers (IUBMB) for LATS2 Gene

Gene Ontology (GO) - Molecular Function for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA,IDA 10871863
genes like me logo Genes that share ontologies with LATS2: view
genes like me logo Genes that share phenotypes with LATS2: view

Animal Models for LATS2 Gene

MGI Knock Outs for LATS2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LATS2 Gene

Localization for LATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LATS2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LATS2 Gene COMPARTMENTS Subcellular localization image for LATS2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for LATS2 Gene

Pathways & Interactions for LATS2 Gene

genes like me logo Genes that share pathways with LATS2: view

Pathways by source for LATS2 Gene

1 BioSystems pathway for LATS2 Gene
2 Reactome pathways for LATS2 Gene
1 KEGG pathway for LATS2 Gene

SIGNOR curated interactions for LATS2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 12853976
GO:0001827 inner cell mass cell fate commitment IEA --
GO:0006468 protein phosphorylation IEA,IDA 10871863
GO:0007067 mitotic nuclear division IEA --
GO:0030216 keratinocyte differentiation IEA --
genes like me logo Genes that share ontologies with LATS2: view

Drugs & Compounds for LATS2 Gene

(4) Drugs for LATS2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for LATS2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with LATS2: view

Transcripts for LATS2 Gene

mRNA/cDNA for LATS2 Gene

Unigene Clusters for LATS2 Gene

LATS, large tumor suppressor, homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LATS2 Gene

No ASD Table

Relevant External Links for LATS2 Gene

GeneLoc Exon Structure for
LATS2
ECgene alternative splicing isoforms for
LATS2

Expression for LATS2 Gene

mRNA expression in normal human tissues for LATS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LATS2 Gene

This gene is overexpressed in Heart (48.6) and Monocytes (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LATS2 Gene



SOURCE GeneReport for Unigene cluster for LATS2 Gene Hs.78960

mRNA Expression by UniProt/SwissProt for LATS2 Gene

Q9NRM7-LATS2_HUMAN
Tissue specificity: Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
genes like me logo Genes that share expression patterns with LATS2: view

Protein tissue co-expression partners for LATS2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LATS2 Gene

Orthologs for LATS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LATS2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LATS2 35
  • 85.84 (n)
  • 89.38 (a)
LATS2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lats2 35
  • 82.32 (n)
  • 86.4 (a)
Lats2 16
Lats2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LATS2 35
  • 99.17 (n)
  • 99.45 (a)
LATS2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lats2 35
  • 82.19 (n)
  • 86.89 (a)
cow
(Bos Taurus)
Mammalia LATS2 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LATS2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LATS2 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves LATS2 35
  • 72.65 (n)
  • 79.16 (a)
LATS2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LATS2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lats2 35
  • 69.35 (n)
  • 73.95 (a)
zebrafish
(Danio rerio)
Actinopterygii lats2 35
  • 64.23 (n)
  • 68.95 (a)
lats2 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wts 37
  • 73 (a)
wts 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T20F10.1 37
  • 48 (a)
wts-1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for LATS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LATS2 Gene

ENSEMBL:
Gene Tree for LATS2 (if available)
TreeFam:
Gene Tree for LATS2 (if available)

Paralogs for LATS2 Gene

Paralogs for LATS2 Gene

(2) SIMAP similar genes for LATS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LATS2: view

Variants for LATS2 Gene

Sequence variations from dbSNP and Humsavar for LATS2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs558614 - 20,988,809(-) TCCCG(C/T)GGCCC reference, missense
VAR_040669 A lung adenocarcinoma sample
rs55842804 - 21,045,755(+) TGCCC(A/C/G)ATTCA reference, missense
rs35368391 - 20,983,311(+) ATCTA(C/T)CAAAA reference, missense
rs45523141 - 20,975,096(+) CGCTG(C/G)CATCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LATS2 Gene

Variant ID Type Subtype PubMed ID
nsv9059 CNV Gain 18304495
esv2747072 CNV Deletion 23290073
nsv64790 CNV Loss 16902084
esv1336723 CNV Insertion 17803354

Variation tolerance for LATS2 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.27; 90.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LATS2 Gene

HapMap Linkage Disequilibrium report
LATS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LATS2 Gene

Disorders for LATS2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LATS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
intracranial abscess
malignant peritoneal mesothelioma
  • malignant mesothelioma of peritoneum
cholinergic urticaria
- elite association - COSMIC cancer census association via MalaCards
Search LATS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LATS2

Genetic Association Database (GAD)
LATS2
Human Genome Epidemiology (HuGE) Navigator
LATS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LATS2
genes like me logo Genes that share disorders with LATS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LATS2 Gene

Publications for LATS2 Gene

  1. Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. (PMID: 10673337) Yabuta N. … Nojima H. (Genomics 2000) 2 3 4 23 67
  2. Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray. (PMID: 19799973) Visser S. … Yang X. (Gene 2010) 3 23
  3. LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma. (PMID: 19008013) Strazisar M. … Glavac D. (Lung Cancer 2009) 3 23
  4. MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer. (PMID: 19501585) Lee K.H. … Lu P.J. (Exp. Cell Res. 2009) 3 23
  5. Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. (PMID: 19855428) Aylon Y. … Oren M. (Oncogene 2009) 3 23

Products for LATS2 Gene

Sources for LATS2 Gene

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