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Aliases for LATS2 Gene

Aliases for LATS2 Gene

  • Large Tumor Suppressor Kinase 2 2 3 5
  • LATS (Large Tumor Suppressor, Drosophila) Homolog 2 2 3
  • Kinase Phosphorylated During Mitosis Protein 3 4
  • Serine/Threonine-Protein Kinase Kpm 3 4
  • Large Tumor Suppressor Homolog 2 3 4
  • Warts-Like Kinase 3 4
  • EC 2.7.11.1 4 61
  • KPM 3 4
  • LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) 2
  • LATS, Large Tumor Suppressor, Homolog 2 3
  • Serine/Threonine-Protein Kinase LATS2 3
  • Serine/Threonine Kinase KPM 3
  • EC 2.7.11 61

External Ids for LATS2 Gene

Previous GeneCards Identifiers for LATS2 Gene

  • GC13M019528
  • GC13M015527
  • GC13M020478
  • GC13M019346
  • GC13M020446
  • GC13M021547
  • GC13M002350

Summaries for LATS2 Gene

Entrez Gene Summary for LATS2 Gene

  • This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for LATS2 Gene

LATS2 (Large Tumor Suppressor Kinase 2) is a Protein Coding gene. Diseases associated with LATS2 include Intracranial Abscess. Among its related pathways are Hippo signaling pathway and Hippo signaling pathway -multiple species. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LATS1.

UniProtKB/Swiss-Prot for LATS2 Gene

  • Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

Gene Wiki entry for LATS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LATS2 Gene

Genomics for LATS2 Gene

Regulatory Elements for LATS2 Gene

Enhancers for LATS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F021059 0.2 ENCODE 23.4 +0.5 501 3.2 ATF1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 BRCA1 GTF3C2 GLIS2 LATS2 RPS7P10 GC13M021039 RNU4-9P
GH13F021038 0.6 Ensembl ENCODE 21.9 +21.7 21668 3.8 PKNOX1 TAL1 JUN GATA2 NCOR1 ETV6 NFE2 MTA2 RNF2 MAFG LATS2 LATS2-AS1 ENSG00000252128 SAP18 MRPL57 SKA3 CRYL1 GC13M021039 RNU4-9P
GH13F021105 0.8 Ensembl ENCODE 20.4 -44.6 -44616 1.2 ZNF121 ZNF362 JUND BCL11A PRDM10 ZNF18 SP7 LATS2 SKA3 MRPL57 RNU4-9P LATS2-AS1 ENSG00000252128 SAP18 IPPKP1 ENSG00000275689 GC13M021127
GH13F021022 0.7 Ensembl ENCODE 17.7 +38.7 38710 2.1 SOX13 ELF3 CTCF SAP130 RAD21 RARA ZNF316 ZNF143 HNF4G CREM LATS2 ENSG00000252128 SAP18 LATS2-AS1 GC13M021039 RNU4-9P
GH13F021031 0.8 Ensembl ENCODE 17.4 +27.7 27683 4.6 CTCF HLF MAX CEBPB FEZF1 NR3C1 RAD21 OSR2 ZNF316 MYC LATS2 LATS2-AS1 ENSG00000252128 SAP18 MRPL57 SKA3 CRYL1 GC13M021039 RNU4-9P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LATS2 on UCSC Golden Path with GeneCards custom track

Promoters for LATS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000512670 783 2401 ATF1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 BRCA1 GLIS2 ZNF207

Genomic Location for LATS2 Gene

Chromosome:
13
Start:
20,973,032 bp from pter
End:
21,061,583 bp from pter
Size:
88,552 bases
Orientation:
Minus strand

Genomic View for LATS2 Gene

Genes around LATS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LATS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LATS2 Gene

Proteins for LATS2 Gene

  • Protein details for LATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRM7-LATS2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LATS2
    Protein Accession:
    Q9NRM7
    Secondary Accessions:
    • B1AM47
    • Q9P2X1

    Protein attributes for LATS2 Gene

    Size:
    1088 amino acids
    Molecular mass:
    120136 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP and AJUBA. Interacts with SNAI1.
    SequenceCaution:
    • Sequence=BAA92381.1; Type=Frameshift; Positions=512, 526; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LATS2 Gene

neXtProt entry for LATS2 Gene

Selected DME Specific Peptides for LATS2 Gene

Q9NRM7:
  • DIKPDNI
  • AHVKAERD
  • HRDIKPDN
  • IKLTDFG
  • KLTDFGL
  • YIAPEVL
  • GHIKLTD
  • WSVGVIL

Post-translational modifications for LATS2 Gene

  • Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activated by STK3/MST2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LATS2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LATS2 (LATS2)
  • Abcam antibodies for LATS2
  • Santa Cruz Biotechnology (SCBT) Antibodies for LATS2

Domains & Families for LATS2 Gene

Suggested Antigen Peptide Sequences for LATS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRM7

UniProtKB/Swiss-Prot:

LATS2_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with LATS2: view

Function for LATS2 Gene

Molecular function for LATS2 Gene

GENATLAS Biochemistry:
LATS Drosophila large tumor suppressor,homolog 2,same as Drosophila loss of the warts
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

Enzyme Numbers (IUBMB) for LATS2 Gene

Gene Ontology (GO) - Molecular Function for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 16413547
GO:0005524 ATP binding IDA 10871863
genes like me logo Genes that share ontologies with LATS2: view
genes like me logo Genes that share phenotypes with LATS2: view

Animal Models for LATS2 Gene

MGI Knock Outs for LATS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LATS2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LATS2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LATS2 Gene

Localization for LATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LATS2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LATS2 Gene COMPARTMENTS Subcellular localization image for LATS2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 12853976
GO:0005634 nucleus NAS,IDA 10673337
GO:0005737 cytoplasm IEA,IDA --
GO:0005815 microtubule organizing center IEA,IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LATS2: view

Pathways & Interactions for LATS2 Gene

genes like me logo Genes that share pathways with LATS2: view

Pathways by source for LATS2 Gene

1 Cell Signaling Technology pathway for LATS2 Gene
1 BioSystems pathway for LATS2 Gene
2 Reactome pathways for LATS2 Gene

SIGNOR curated interactions for LATS2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 12853976
GO:0001827 inner cell mass cell fate commitment IEA --
GO:0001828 inner cell mass cellular morphogenesis IEA --
GO:0006468 protein phosphorylation IDA 10871863
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with LATS2: view

Drugs & Compounds for LATS2 Gene

(4) Drugs for LATS2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for LATS2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with LATS2: view

Transcripts for LATS2 Gene

Unigene Clusters for LATS2 Gene

LATS, large tumor suppressor, homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LATS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LATS2 Gene

No ASD Table

Relevant External Links for LATS2 Gene

GeneLoc Exon Structure for
LATS2
ECgene alternative splicing isoforms for
LATS2

Expression for LATS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LATS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LATS2 Gene

This gene is overexpressed in Heart (48.6) and Monocytes (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LATS2 Gene



Protein tissue co-expression partners for LATS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LATS2 Gene:

LATS2

SOURCE GeneReport for Unigene cluster for LATS2 Gene:

Hs.78960

mRNA Expression by UniProt/SwissProt for LATS2 Gene:

Q9NRM7-LATS2_HUMAN
Tissue specificity: Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
genes like me logo Genes that share expression patterns with LATS2: view

Primer Products

No data available for mRNA differential expression in normal tissues for LATS2 Gene

Orthologs for LATS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LATS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LATS2 34 35
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia LATS2 34 35
  • 85.84 (n)
mouse
(Mus musculus)
Mammalia Lats2 34 16 35
  • 82.32 (n)
rat
(Rattus norvegicus)
Mammalia Lats2 34
  • 82.19 (n)
oppossum
(Monodelphis domestica)
Mammalia LATS2 35
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LATS2 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LATS2 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves LATS2 34 35
  • 72.65 (n)
lizard
(Anolis carolinensis)
Reptilia LATS2 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lats2 34
  • 69.35 (n)
zebrafish
(Danio rerio)
Actinopterygii lats2 34 35
  • 64.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta wts 36 35
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea T20F10.1 36
  • 48 (a)
wts-1 35
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
OneToMany
Species where no ortholog for LATS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LATS2 Gene

ENSEMBL:
Gene Tree for LATS2 (if available)
TreeFam:
Gene Tree for LATS2 (if available)

Paralogs for LATS2 Gene

(2) SIMAP similar genes for LATS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LATS2: view

Variants for LATS2 Gene

Sequence variations from dbSNP and Humsavar for LATS2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_040669 A lung adenocarcinoma sample
rs1003966 -- 21,038,020(+) tggac(C/T)gcttg intron-variant
rs1050345 -- 20,973,065(-) CTGGC(A/C)CAATT utr-variant-3-prime
rs10592570 -- 21,008,196(+) CTACT(-/ACT)GTAGG intron-variant
rs10659630 -- 20,973,980(+) CCCCC(-/C/CA)AAAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LATS2 Gene

Variant ID Type Subtype PubMed ID
esv1336723 CNV insertion 17803354
esv3343586 CNV insertion 20981092
nsv1037082 CNV gain 25217958
nsv1078303 OTHER inversion 25765185
nsv1113546 CNV deletion 24896259
nsv1118260 CNV deletion 24896259
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv561243 CNV loss 21841781
nsv64790 CNV deletion 16902084
nsv9059 CNV gain 18304495

Variation tolerance for LATS2 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.27; 90.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LATS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LATS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LATS2 Gene

Disorders for LATS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LATS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intracranial abscess
- elite association - COSMIC cancer census association via MalaCards
Search LATS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LATS2

Genetic Association Database (GAD)
LATS2
Human Genome Epidemiology (HuGE) Navigator
LATS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LATS2
genes like me logo Genes that share disorders with LATS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LATS2 Gene

Publications for LATS2 Gene

  1. Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. (PMID: 10673337) Yabuta N. … Nojima H. (Genomics 2000) 2 3 4 22 64
  2. The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. (PMID: 15131260) Powzaniuk M. … Bai C. (Mol. Endocrinol. 2004) 3 4 22 64
  3. Lats2, a putative tumor suppressor, inhibits G1/S transition. (PMID: 12853976) Li Y. … Tao W. (Oncogene 2003) 3 4 22 64
  4. Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. (PMID: 10871863) Hori T. … Uchiyama T. (Oncogene 2000) 3 4 22 64
  5. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. (PMID: 21952048) Zhang K. … Longmore G.D. (EMBO J. 2012) 3 4 64

Products for LATS2 Gene

Sources for LATS2 Gene

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