LATS2 Gene
protein-coding GIFtS: 61
GCID: GC13M021547
|
|
LATS, large tumor suppressor, homolog 2 (Drosophila)(Previous names: LATS (large tumor suppressor, Drosophila) homolog 2 )
| |
Aliases
for LATS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| LATS, Large Tumor Suppressor, Homolog 2 (Drosophila)1 2 | | KPM2 3 | | LATS (Large Tumor Suppressor, Drosophila) Homolog 21 2 | | EC 2.7.11.13 8 | | Kinase Phosphorylated During Mitosis Protein2 3 | | Serine/Threonine Kinase KPM2 | | Large Tumor Suppressor Homolog 22 3 | | Serine/Threonine-Protein Kinase LATS22 | | Serine/Threonine-Protein Kinase Kpm2 3 | | EC 2.7.118 | | Warts-Like Kinase2 3 | | |
Export aliases for LATS2 gene to outside databasesPrevious GC identifers: GC13M019528 GC13M015527 GC13M020478 GC13M019346 GC13M020446 GC13M002350 |
Summaries
for LATS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LATS2:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The proteinlocalizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteinsaurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. Italso interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds tocytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. (providedby RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control andtumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of akinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulatecellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor whichplays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negativelyregulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgenreceptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances itsepithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity isindependent of its effects upon YAP1 or WWTR1/TAZ
Gene Wiki entry for LATS2
|
Genomic Views
for LATS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LATS2 gene promoter:
Tal-1 p53 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Cdc5 GATA-1 FOXL1 E47 Arnt c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for LATS2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LATS2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q11-q12 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q11-q12LATS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M021547: view genomic region
(about GC identifiers)
Start:
|
21,547,171 bp from pter |
End:
|
21,635,722 bp from pter |
Size:
|
88,552 bases |
Orientation:
|
minus strand |
|
Proteins
for LATS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase LATS2 Size: 1088 amino acids; 120136 Da
Cofactor: Magnesium
Subunit: Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and thiscomplex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome.Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP andAJUBA. Interacts with SNAI1
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus.Note=Co-localizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to thespindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stressby nocodazole treatment
Sequence caution: Sequence=BAA92381.1; Type=Frameshift; Positions=512, 526;
Secondary accessions: B1AM47 Q9P2X1Explore the universe of human proteins at neXtProt for LATS2: NX_Q9NRM7
Post-translational modifications:
Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activatedby STK3/MST21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NRM7
4/8 DME Specific Peptides for LATS2 (Q9NRM7) (see all 8)
LATS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055387.2
ENSEMBL proteins: ENSP00000372035 ENSP00000441817 Reactome Protein details: Q9NRM7
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
LATS2 for ontologies About GeneDecksing
LATS2 Antibody Products:
Assay Products for LATS2: |
Protein
Domains /
Families
for LATS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LATS2 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q9NRM7ProtoNet protein and cluster: Q9NRM7 1 Blocks protein family: IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase familySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 UBA domain |
Function
for LATS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control andtumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of akinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulatecellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor whichplays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negativelyregulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgenreceptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances itsepithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity isindependent of its effects upon YAP1 or WWTR1/TAZCatalytic activity: ATP + a protein = ADP + a phosphoprotein Genatlas biochemistry entry for LATS2:LATS Drosophila large tumor suppressor,homolog 2,same as Drosophila loss of the warts
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LATS2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LATS2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LATS2 (NM_014572) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LATS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LATS2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
LATS2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for LATS2:
Animal Models:
Mouse knock-out Lats2tm1Noj for LATS2
10 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Lats2):
LATS2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for LATS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell Cycle / Checkpoint Control | | | 2 | Signaling by Hippo | | | 3 | Coregulation of Androgen receptor activity | | | 4 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for LATS2
1  BioSystems Pathway for LATS2
2 
Reactome Pathways for LATS2
LATS2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LATS2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/33 Interacting proteins for LATS2 (Q9NRM71, 2, 3 ENSP000003720354) via UniProtKB, MINT, STRING, and/or I2D (see all 33)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| AJUBA | Q96IF12, 3, ENSP000002627134 | MINT-1772128 MINT-1778030 MINT-1772055 MINT-1790017 MINT-1771993 MINT-1772097 I2D:
score=2 STRING: ENSP00000262713 | | MOB1A | Q9H8S91, 3, ENSP000003793644 | EBI-3506895,EBI-748229 I2D:
score=1 STRING: ENSP00000379364 | | MOB1B | Q7L9L41, 3, ENSP000003101894 | EBI-3506895,EBI-2558745 I2D:
score=1 STRING: ENSP00000310189 | | SNAI1 | O958632, ENSP000002440504 | MINT-8313496 MINT-8313510 STRING: ENSP00000244050 | | STK3 | Q131883, ENSP000003905004 | I2D:
score=2 STRING: ENSP00000390500 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
LATS2 for ontologies About GeneDecksing
|
Drugs & Compounds
for LATS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
LATS2 for compounds About GeneDecksing
 Browse Tocris compounds for LATS2
3 HMDB Compounds for LATS2 About this table
2 Novoseek chemical compound relationships for LATS2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
25.9 |
2 |
12624101 (1), 10871863 (1) |
| serine |
10.8 |
2 |
12624101 (1), 10871863 (1) |
Search CenterWatch for drugs/clinical trials and news about LATS2
|
Transcripts
for LATS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LATS2 gene: NM_014572.2 Unigene Cluster for LATS2: LATS, large tumor suppressor, homolog 2 (Drosophila) Hs.78960 [show with all ESTs]Unigene Representative Sequence: NM_0145724 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382592(uc009zzs.3 uc001unr.4) ENST00000472754 ENST00000496544
ENST00000542899
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LATS2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LATS2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LATS2 (NM_014572) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LATS2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LATS2 |
Additional cDNA sequence: AB028019.1 AF207547.1 AK027853.1 AK123520.1 AK314235.1 BC036437.1 BC071572.1 12 DOTS entries: DT.100039184 DT.40291556 DT.436795 DT.445806 DT.91797242 DT.120783972 DT.40249141 DT.100041790 DT.40289254 DT.95169192 DT.99971266 DT.95109747 24/144 AceView cDNA sequences (see all 144): NM_014572 BM673297 AW073767 BQ445980 AA954532 AI580897 AI700975 AI087266 BI964175 AA431967 BM978230 BQ926752 BQ574712 AA620865 AA971313 AI273460 AI566207 BQ898648 BE999991 AF207547 AI636200 AW297573 AA318524 AI003807
GeneLoc Exon Structure
|
Expression
for LATS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LATS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTAGGTTC
About this image
See LATS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LATS2
SOURCE GeneReport for Unigene cluster: Hs.78960
UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7Tissue specificity: Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissuesexamined
SABiosciences Expression via Pathway-Focused PCR Array including LATS2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LATS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LATS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LATS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LATS2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS2 |
Orthologs
for LATS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LATS2 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LATS21 |
LATS, large tumor suppressor, homolog 2 (Drosophila) |
72.5(n)
78.98(a) |
|
418949 XM_417143.3 XP_417143.3 |
lizard
(Anolis carolinensis) |
Reptilia |
LATS26 |
-- |
74(a) |
1 ↔ 1 |
3(187653641-187710758) |
zebrafish
(Danio rerio) |
Actinopterygii |
lats21 |
LATS, large tumor suppressor, homolog 2 (Drosophila) |
64.04(n)
68.53(a) |
|
567674 NM_001123307.1 NP_001116779.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
wts3 |
G1/S transition of mitotic cell cycle
protein more |
73(a) |
|
100A5 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
T20F10.13 |
Protein kinase C terminal domain |
48(a) |
|
I(10300194-10305901) -- |
ENSEMBL Gene Tree for LATS2 (if available)
TreeFam Gene Tree for LATS2 (if available) |
Paralogs
for LATS2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LATS2 gene
- CDC42BPG2 DMPK2 LATS12 STK38L2 CDC42BPB2 STK382 CIT2 ROCK12
- CDC42BPA2 ROCK22
3 SIMAP similar genes for LATS2 using alignment to 1 protein entry: LATS2_HUMAN:LATS1 PRKACG SGK1
LATS2 for paralogs About GeneDecksing
|
Genomic Variants
for LATS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LATS2 (21547171 - 21635722 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LATS2
1 CNV: 30632 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LATS2 |
|
Disorders
/ Diseases
for LATS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LATS2 for disorders About GeneDecksing
OMIM gene information: 604861
OMIM disorders: --
19  diseases for LATS2: About MalaCardscholinergic urticaria intracranial abscess testicular germ cell tumor soft tissue sarcoma
germ cell tumor cerebrovascular accident esophageal squamous cell carcinoma squamous cell carcinoma
small cell carcinoma urticaria esophagitis breast cancer
sarcoma esophageal cancer gastric cancer astrocytoma
carcinoma prostate cancer prostatitis
1 disease from the University of Copenhagen DISEASES database for LATS2:Intracranial abscess 4 Novoseek disease relationships for LATS2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: LATS2 (2 documents)
Export disorders for LATS2 gene to outside databases
|
Publications
for LATS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LATS2 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with LATS2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. (PubMed id 10673337)1, 2, 3, 9 Yabuta N.... Nojima H. (2000)
- Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. (PubMed id 10871863)1, 2, 9 Hori T.... Uchiyama T. (2000)
- The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. (PubMed id 15131260)1, 2, 9 Powzaniuk M.... Bai C. (2004)
- Lats2, a putative tumor suppressor, inhibits G1/S transition. (PubMed id 12853976)1, 2, 9 Li Y.... Tao W. (2003)
- Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. (PubMed id 21952048)1, 2 Zhang K....Longmore G.D. (2012)
- Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)1, 2 Chow A....Yang X. (2010)
- Tumor suppressor LATS1 is a negative regulator of oncogene YAP. (PubMed id 18158288)1, 2 Hao Y....Yang X. (2008)
- LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. (PubMed id 16413547)1, 2 Abe Y.... Yamamoto T. (2006)
- The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PubMed id 15688006)1, 2 Chan E.H.Y.... Sillje H.H.W. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
|
External Searches for LATS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LATS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LATS2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LATS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for LATS2 gene:
Search GeneIP for patents involving LATS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LATS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LATS2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LATS2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LATS2 | | | OriGene Protein Over-expression Lysate for LATS2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LATS2 | | OriGene 3'-UTR Clone for LATS2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LATS2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LATS2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LATS2 | | OriGene Custom Protein Services for LATS2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LATS2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LATS2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LATS2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LATS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LATS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LATS2 |
| |
 |  |  |  | |
| | Antibodies & Assays for LATS2 |
| | | | Search Tocris compounds for LATS2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | LATS2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS2 |
|  |  |  | | | | Search ThermoFisher Antibodies for LATS2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LATS2 |
|
|
|
|
