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LATS2 Gene

protein-coding   GIFtS: 65
GCID: GC13M021547

Large Tumor Suppressor Kinase 2

(Previous names: LATS (large tumor suppressor, Drosophila) homolog 2, LATS,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Large Tumor Suppressor Kinase 21 2     EC 2.7.11.13 8
LATS (Large Tumor Suppressor, Drosophila) Homolog 21 2     LATS, Large Tumor Suppressor, Homolog 2 (Drosophila)1
Kinase Phosphorylated During Mitosis Protein2 3     LATS, Large Tumor Suppressor, Homolog 22
Large Tumor Suppressor Homolog 22 3     Serine/Threonine Kinase KPM2
Serine/Threonine-Protein Kinase Kpm2 3     Serine/Threonine-Protein Kinase LATS22
Warts-Like Kinase2 3     EC 2.7.118
KPM2 3     

External Ids:    HGNC: 65151   Entrez Gene: 265242   Ensembl: ENSG000001504577   OMIM: 6048615   UniProtKB: Q9NRM73   

Export aliases for LATS2 gene to outside databases

Previous GC identifers: GC13M019528 GC13M015527 GC13M020478 GC13M019346 GC13M020446 GC13M002350


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LATS2 Gene:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein
localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal
proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset
of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with
p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive
gene expression. (provided by RefSeq, Jul 2008)

GeneCards Summary for LATS2 Gene:
LATS2 (large tumor suppressor kinase 2) is a protein-coding gene. Diseases associated with LATS2 include intracranial abscess, and cholinergic urticaria. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7
Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size
control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is
composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into
the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as
a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and
genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention
and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration
activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ

Gene Wiki entry for LATS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LATS2 gene promoter:
         Tal-1   p53   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Cdc5   GATA-1   FOXL1   E47   Arnt   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LATS2 promoter sequence
   Search Chromatin IP Primers for LATS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LATS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q11-q12   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11-q12

LATS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LATS2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M021547:  view genomic region     (about GC identifiers)

Start:
21,547,171 bp from pter      End:
21,635,722 bp from pter
Size:
88,552 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase LATS2  
Size: 1088 amino acids; 120136 Da
Cofactor: Magnesium
Subunit: Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and this
complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome.
Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP
and AJUBA. Interacts with SNAI1
Sequence caution: Sequence=BAA92381.1; Type=Frameshift; Positions=512, 526;
Secondary accessions: B1AM47 Q9P2X1

Explore the universe of human proteins at neXtProt for LATS2: NX_Q9NRM7

Explore proteomics data for LATS2 at MOPED

Post-translational modifications: 

  • Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and
    activated by STK3/MST21
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LATS2 (Q9NRM7) (see all 8)
     YIAPEVL  GHIKLTD  KLTDFGL  DIKPDNI 


    See LATS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055387.2  
    ENSEMBL proteins: 
     ENSP00000372035   ENSP00000441817  
    Reactome Protein details: Q9NRM7

    LATS2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for LATS2
    OriGene Custom MassSpec
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    Novus Biologicals LATS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LATS2

    LATS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals LATS2 Antibodies
    Abcam antibodies for LATS2
    Cloud-Clone Corp. Antibodies for LATS2
    Search ThermoFisher Antibodies for LATS2
    LSBio Antibodies in human, mouse, rat for LATS2

    LATS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for LATS2
    Cloud-Clone Corp. CLIAs for LATS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: LATS, large tumor suppressor, homolog 2 (Drosophila)
    Other AGC kinases
    NDR family

    Selected InterPro protein domains (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q9NRM7

    ProtoNet protein and cluster: Q9NRM7

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    LATS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LATS2_HUMAN, Q9NRM7
    Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size
    control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is
    composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
    phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
    and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into
    the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as
    a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and
    genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
    Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention
    and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration
    activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for LATS2:
    LATS Drosophila large tumor suppressor,homolog 2,same as Drosophila loss of the warts

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16413547
    GO:0005524ATP binding IDA10871863
         
    LATS2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LATS2:
     Increased ID2::GFP protein exp  Increased apoptosis 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Lats2):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     no phenotypic analysis 

    LATS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lats2tm1Noj for LATS2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LATS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LATS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LATS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LATS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target LATS2:
    hsa-mir-372-3p (MIRT002446), hsa-mir-373-3p (MIRT001754), hsa-mir-31-5p (MIRT000491), hsa-mir-93-5p (MIRT007185)

    Block miRNA regulation of human, mouse, rat LATS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LATS2 (see all 57):
    hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-25 hsa-miR-3074-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidLATS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LATS2
    Predesigned siRNA for gene silencing in human, mouse, rat LATS2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for LATS2 (see all 9)
    OriGene ORF clones in mouse, rat for LATS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LATS2 (NM_014572)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LATS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LATS2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LATS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for LATS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LATS2_HUMAN, Q9NRM7: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm,
    cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early
    prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.
    Translocates to the nucleus upon mitotic stress by nocodazole treatment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA12853976
    GO:0005634nucleus NAS10673337
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--

    LATS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LATS2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.58
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    3Signaling by Hippo
    Signaling by Hippo
    4Hippo signaling pathway
    Hippo signaling pathway
    5Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for LATS2
        Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for LATS2
        Coregulation of Androgen receptor activity

    1 Reactome Pathway for LATS2
        Signaling by Hippo


    1 Kegg Pathway  (Kegg details for LATS2):
        Hippo signaling pathway


    LATS2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including LATS2: 
              Hedgehog Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LATS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LATS2 (Q9NRM71, 2, 3 ENSP000003720354) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AJUBAQ96IF11, 2, 3, ENSP000002627134EBI-3506895,EBI-949782 MINT-1772128 MINT-1778030 MINT-1772055 MINT-1790017 MINT-1771993 MINT-1772097 I2D: score=2 STRING: ENSP00000262713
    MOB1AQ9H8S91, 3, ENSP000003793644EBI-3506895,EBI-748229 I2D: score=1 STRING: ENSP00000379364
    MOB1BQ7L9L41, 3, ENSP000003101894EBI-3506895,EBI-2558745 I2D: score=1 STRING: ENSP00000310189
    SNAI1O958632, ENSP000002440504MINT-8313496 MINT-8313510 STRING: ENSP00000244050
    STK3Q131883, ENSP000003905004I2D: score=2 STRING: ENSP00000390500
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA12853976
    GO:0006468protein phosphorylation IDA10871863
    GO:0007067mitosis IEA--
    GO:0009755hormone-mediated signaling pathway IDA15131260
    GO:0030216keratinocyte differentiation IEA--

    LATS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LATS2

    3 HMDB Compounds for LATS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for LATS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 25.9 2 12624101 (1), 10871863 (1)
    serine 10.8 2 12624101 (1), 10871863 (1)



    LATS2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LATS2 gene: 
    NM_014572.2  

    Unigene Cluster for LATS2:

    LATS, large tumor suppressor, homolog 2 (Drosophila)
    Hs.78960  [show with all ESTs]
    Unigene Representative Sequence: NM_014572
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382592(uc009zzs.3 uc001unr.4) ENST00000472754 ENST00000542899

    miRNA
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    Block miRNA regulation of human, mouse, rat LATS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LATS2 (see all 57):
    hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-25 hsa-miR-3074-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidLATS2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: LATS2 (NM_014572)
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      QuantiFast Probe-based Assays in human, mouse, rat LATS2

    Additional mRNA sequence: 

    AB028019.1 AF207547.1 AK027853.1 AK123520.1 AK314235.1 BC036437.1 BC071572.1 

    12 DOTS entries:

    DT.100039184  DT.40291556  DT.436795  DT.445806  DT.91797242  DT.120783972  DT.40249141  DT.100041790 
    DT.40289254  DT.95169192  DT.99971266  DT.95109747 

    Selected AceView cDNA sequences (see all 144):

    BI964175 AI580897 AW297573 AA431967 AF207547 AA971313 BE999991 AI273460 
    AI636200 AI566207 BQ574712 NM_014572 BM978230 AA954532 AI224095 BQ898648 
    AA318524 BQ926752 BQ445980 BM052863 AA873139 AI087266 AI700975 AW073767 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LATS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTAGGTTC
    LATS2 Expression
    About this image


    LATS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Testis (Reproductive System)
    LATS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LATS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78960

    UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7
    Tissue specificity: Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues
    examined

        Pathway & Disease-focused RT2 Profiler PCR Array including LATS2: 
              Hedgehog Signaling Pathway in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LATS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LATS2
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    QuantiFast Probe-based Assays in human, mouse, rat LATS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LATS2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lats21 , 5 large tumor suppressor 21, 5 82.32(n)1
    86.4(a)1
      14 (30.28 cM)5
    505231  NM_015771.21  NP_056586.21 
     576420775 
    chicken
    (Gallus gallus)
    Aves LATS21 LATS, large tumor suppressor, homolog 2 (Drosophila) 72.65(n)
    79.16(a)
      418949  XM_417143.4  XP_417143.3 
    lizard
    (Anolis carolinensis)
    Reptilia LATS26
    large tumor suppressor kinase 2
    75(a)
    1 ↔ 1
    3(187653641-187724849)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lats21 large tumor suppressor kinase 2 69.35(n)
    73.95(a)
      100124721  NM_001102704.1  NP_001096174.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lats21 LATS, large tumor suppressor, homolog 2 (Drosophila) 64.23(n)
    68.95(a)
      567674  NM_001128256.1  NP_001121728.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wts3 G1/S transition of mitotic cell cycle
    protein more
    73(a)   100A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea T20F10.13 Protein kinase C terminal domain 48(a)   I(10300194-10305901)   --


    ENSEMBL Gene Tree for LATS2 (if available)
    TreeFam Gene Tree for LATS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LATS2 gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK38L2  STK382  MASTL2  CIT2  
    ROCK12  CDC42BPA2  ROCK22  
    2 SIMAP similar genes for LATS2 using alignment to 1 protein entry:     LATS2_HUMAN:
    LATS1    PRKACG

    LATS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LATS2 (see all 2190)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406694
    A lung adenocarcinoma sample4--see VAR_0406692 G E mis40--------
    rs95523141,2
    C,F--21546891(+) ATCACC/TCACCA 1 -- ds50017Minor allele frequency- T:0.29NA WA CSA EA 370
    rs1386906421,2
    C--21546963(+) TTTTAC/TGCAAG 1 -- ds50010--------
    rs1417857761,2
    --21546964(+) TTTACA/GCAAGT 1 -- ds50010--------
    rs1877275321,2
    --21547061(+) CCCTGC/TCTGTG 1 -- ds50010--------
    rs118427181,2
    C,F,H--21547096(+) ACAGGG/AGAAGC 1 -- ds50017Minor allele frequency- A:0.29NA WA CSA EA 368
    rs5842991,2
    C,F,O,A--21547127(+) TGAGAG/AAGGCA 1 -- ds50018Minor allele frequency- A:0.22NA WA EA 368
    rs1146018651,2
    F--21547171(+) ACTACG/AGGATT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs5352331,2
    C,F,O,A,H--21547317(-) GTGCCA/GTGTTG 1 -- ut3126Minor allele frequency- G:0.22MN NS EA NA WA 2632
    rs1927394531,2
    --21547355(+) GTCACA/GACGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LATS2 (21547171 - 21635722 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LATS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747072CNV Deletion23290073
    esv1336723CNV Insertion17803354
    nsv64790CNV Loss16902084
    nsv9059CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LATS2
    DNA2.0 Custom Variant and Variant Library Synthesis for LATS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604861    OMIM disorders: --

    19 diseases for LATS2:    
    About MalaCards
    intracranial abscess    cholinergic urticaria    urticaria    soft tissue sarcoma
    small cell carcinoma    testicular germ cell tumor    germ cell tumors    malignant mesothelioma
    esophageal cancer    esophagitis    esophageal squamous cell carcinoma    astrocytoma
    nasopharyngitis    sarcoma    squamous cell carcinoma    breast cancer
    prostate cancer    prostatitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for LATS2:
    Intracranial abscess

    LATS2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for LATS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    warts 79.6 9 10871863 (3), 12624101 (2), 10673337 (2), 15131260 (1) (see all 5)
    tumors 38.3 35 15746036 (5), 19855428 (3), 12370754 (3), 12624101 (2) (see all 13)
    cancer 16.8 2 10871863 (1), 19799973 (1)
    breast cancer 9.46 11 15746036 (4), 17297610 (2), 19799973 (1)

    Genetic Association Database (GAD): LATS2
    Human Genome Epidemiology (HuGE) Navigator: LATS2 (2 documents)

    Export disorders for LATS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LATS2 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with LATS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. (PubMed id 10673337)1, 2, 3, 9 Yabuta N.... Nojima H. (Genomics 2000)
    2. Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. (PubMed id 10871863)1, 2, 9 Hori T.... Uchiyama T. (Oncogene 2000)
    3. The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. (PubMed id 15131260)1, 2, 9 Powzaniuk M.... Bai C. (Mol. Endocrinol. 2004)
    4. Lats2, a putative tumor suppressor, inhibits G1/S transition. (PubMed id 12853976)1, 2, 9 Li Y.... Tao W. (Oncogene 2003)
    5. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. (PubMed id 21952048)1, 2 Zhang K.... Longmore G.D. (EMBO J. 2012)
    6. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    7. Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)1, 2 Chow A.... Yang X. (Int. J. Cancer 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. (PubMed id 18158288)1, 2 Hao Y.... Yang X. (J. Biol. Chem. 2008)
    10. LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. (PubMed id 16413547)1, 2 Abe Y.... Yamamoto T. (FEBS Lett. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26524 HGNC: 6515 AceView: LATS2 Ensembl:ENSG00000150457 euGenes: HUgn26524
    ECgene: LATS2 Kegg: 26524 H-InvDB: LATS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LATS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LATS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LATS2 gene:
    Search GeneIP for patents involving LATS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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