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LATS2 Gene

protein-coding GIFtS: 59

GC13M020446

LATS, large tumor suppressor, homolog 2 (Drosophila)
(Previous names: LATS (large tumor suppressor, Drosophila) homolog 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 2.7.11.1 ^³
FLJ13161 ^²
KPM ^², ³
OTTHUMP00000018106 ^²

Descriptions
Kinase phosphorylated during mitosis protein ^², ³
LATS (large tumor suppressor, Drosophila) homolog 2 ^¹, ²
LATS, large tumor suppressor, homolog 2 ^²
LATS, large tumor suppressor, homolog 2 (Drosophila) ^²
Large tumor suppressor homolog 2 ^³
Serine/threonine-protein kinase kpm ^³
Warts-like kinase ^², ³
serine/threonine kinase KPM ^²

External Ids
HGNC: 6515¹
Entrez Gene: 26524²
UniProtKB: Q9NRM7³
Ensembl: ENSG00000150457⁷

Search outside databases for aliases for LATS2 gene

Previous GC identifers: GC13M019528 GC13M015527 GC13M020478 GC13M019346

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LATS2:

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family.

The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts

with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin

and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53

and may function in a positive feedback loop with p53 that responds to cytoskeleton damage.

Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided

by RefSeq]

UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7

Function: Tumor suppressor which plays a critical role in centrosome duplication, maintenance of

mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating

cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor

Gene Wiki entry for LATS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LATS2 gene

Entrez Gene cytogenetic band: 13q11-q12 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q11-q12

LATS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M020446: (about GC identifiers)

Start:	20,445,175 bp from pter
End:	20,533,722 bp from pter
Size:	88,548 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase LATS2

Size: 1088 amino acids; 120136 Da

Cofactor: Magnesium

Subunit: Interacts with and is phosphorylated by STK6. Binds to AR. Interacts with JUB during

mitosis and this complex regulates organization of the spindle apparatus through recruitment of

gamma-tubulin to the centrosome

Subcellular location: Centrosome. Cytoplasm. Note=Co-localizes with STK6 at the centrosomes during

interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to

the midbody during cytokinesis

Sequence caution: Sequence=BAA92381.1; Type=Frameshift; Positions=512, 526;

Secondary accessions: B1AM47 Q9P2X1

Post-translational modifications:

Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle.

Phosphorylated and activated by STK3¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055387.2

ENSEMBL proteins:

ENSP00000372035

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LATS2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	12853976
GO:0005634	nucleus	NAS	10673337
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IEA	--

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Antibodies for LATS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LATS2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (LATS2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LATS2)
	Novus Biologicals Antibody for LATS2

Assays for LATS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9NRM7

ProtoNet protein and cluster: Q9NRM7

1 Blocks protein family: IPB000961 Protein kinase C-terminal domain

UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 UBA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LATS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LATS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014572

Applied Biosystems Silencer® siRNAs for LATS2

Sigma-Aldrich siRNA and siRNA Panels for LATS2

Sigma-Aldrich shRNA Panels and shRNA for LATS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014572
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014572
untagged cDNA clones in CMV expression vector (see all 2): NM_014572

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014572

UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7

Function: Tumor suppressor which plays a critical role in centrosome duplication, maintenance of

mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating

cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1

Genatlas biochemistry entry for LATS2:

LATS Drosophila large tumor suppressor,homolog 2,same as Drosophila loss of the warts

11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Lats2):

	behavior/neurological	cellular	craniofacial	embryogenesis
growth/size	hearing/vestibular/ear	lethality-prenatal/perinatal	muscle	nervous system
no phenotypic analysis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IDA	10871863
GO:0005524	ATP binding	IDA	10871863
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for LATS2

5/10 Interacting proteins for LATS2 (Q9NRM7² ENSP00000372035³) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUB	Q96IF1², ENSP00000262713³	MINT-1772128 MINT-1778030 MINT-1772055 MINT-1790017 MINT-1771993 MINT-1772097 STRING (score=.849)
KLK3	ENSP00000314151³	STRING (score=.978)
TP53	ENSP00000269305³	STRING (score=.949)
MDM2	ENSP00000258149³	STRING (score=.934)
TSHR	ENSP00000298171³	STRING (score=.786)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IDA	12853976
GO:0006468	protein amino acid phosphorylation	IDA	10871863
GO:0007067	mitosis	IEA	--
GO:0007243	protein kinase cascade	IDA	10871863
GO:0009755	hormone-mediated signaling	IDA	15131260

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LATS2
1 Novoseek chemical compound relationship for LATS2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	30.49	2	12624101 (1), 10871863 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LATS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LATS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014572

Sigma-Aldrich siRNA and siRNA Panels for LATS2

Sigma-Aldrich shRNA Panels and shRNA for LATS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014572

REFSEQ mRNAs for LATS2 gene:

NM_014572.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014572

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014572
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014572
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_014572

Additional cDNA sequence:

AB028019.1 AF207547.1 AK027853.1 AK123520.1 AK314235.1 BC036437.1 BC071572.1

12 DOTS entries:

DT.40291556 DT.100039184 DT.436795 DT.445806 DT.91797242 DT.40289254 DT.120783972 DT.40249141

DT.100041790 DT.95169192 DT.95109747 DT.99971266

24/144 AceView cDNA sequences (see all 144 ):

BQ898648 AA971313 AA620865 BQ926752 AI636200 AI273460 AI700975 AI580897

BM052863 AA431967 BQ574712 AA873139 AW297573 AI566207 BQ445980 AI003807

AI224095 BM978230 AA318524 AA954532 NM_014572 BM673297 AW073767 BE999991

highest scoring ESTs for LATS2:

AW505364 BM146712 BM148168 CB053505 U69566 AF207547 AA318420 AA318524 AA330617 AA330618

Unigene Cluster for LATS2:

LATS, large tumor suppressor, homolog 2 (Drosophila)

Hs.78960 [show with all ESTs]

Unigene Representative Sequence: NM_014572

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000382592

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LATS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LATS2

¹ / ² / ³

12 probe-sets matching LATS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
70443_at²^{, 3}	U95-E	1	1.00	1.00	0.85	0.82	AI745254	0.60	1.00	0.82	1
83093_at²^{, 3}	U95-E	1	1.00	1.00	0.78	0.58	AI916545	0.80	0.80	0.80	1
60514_at²^{, 3}	U95-C	1	1.00	1.00	0.90	1.22	U69566	0.80	1.00	0.91	1
72751_at*²^{, 3}	U95-D	1	0.88	1.00	0.15	1.41	N67652	0.40	1.00	0.76	1
230348_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI745254	0.60	1.00	0.82	1
227013_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI535735	0.40	1.00	0.76	1
223379_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF434601	0.60	1.00	0.82	1
223380_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF207547	0.80	0.88	0.84	1
230348_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227013_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223379_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223380_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LATS2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGTAGGTTC

SOURCE GeneReport for Unigene cluster: Hs.78960
UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7
Tissue specificity: Expressed at high levels in heart and skeletal muscle and at lower levels in
all other tissues examined

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for LATS2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LATS2¹	--	LATS, large tumor suppressor, homolog 2 (Drosophila)	85.6(n) 89.11(a)	477343 XM_534537.2 XP_534537.2
chimpanzee (Pan troglodytes)	LATS2¹	--	LATS, large tumor suppressor, homolog 2 (Drosophila)	99.19(n) 99.53(a)	452466 XM_509566.2 XP_509566.2
cow (Bos taurus)	LATS2¹	--	LATS, large tumor suppressor, homolog 2 (Drosophila)	77.72(n) 79.38(a)	508208 XM_584953.3 XP_584953.3
rat (Rattus norvegicus)	Lats2¹	--	large tumor suppressor 2	82.32(n) 87.27(a)	305922 XM_224169.4 XP_224169.2
mouse (Mus musculus)	Lats2^{1, 5}	14⁵	large tumor suppressor 2^{1, 5}	82.48(n)¹ 86.69(a)¹	50523¹ NM_015771.2¹ NP_056586.2¹ AB023958⁵ AI414965⁵ (see all 30)

About this table Species with no ortholog for LATS2

ENSEMBL Gene Tree for LATS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LATS2 gene

LATS1² ROCK1² ROCK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/707 NCBI SNPs in LATS2 are shown (see all 707 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 131)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs535233^1,2	A,C,F,H,O	20445317(-)	`GTGCCA/GTGTTG`	1	--	ut3¹		14		MN EU EA WA NS	1122
	rs584299^1,2	A,C,O	20445127(+)	`TGAGAA/GAGGCA`	1	--	ng5¹		0	--	--	--	--
	rs9552315^1,2	A,C,F	20445984(+)	`ACCAGC/TTCTAC`	1	--	ut3¹		1		NA	90
	rs558614^1,2	A,C,H	20460948(-)	`TCCCGT/CGGCCC`	1	V/A	mis¹ ese³		2		MN EU	304
	rs507186^1,2	C,F,H	20446026(-)	`ACACAC/TGTCCG`	1	--	ut3¹ ese³		4		EU EA WA	414
--	rs7330843^1,2	A	20445832(+)	`GAACAA/GAAAAA`	1	--	ut3¹ trp³		0	--	--	--	--
	rs11842718^1,2	C	20445096(+)	`ACAGGA/GGAAGC`	1	--	ng5¹		0	--	--	--	--
	rs35368391^1,2	C	20455450(+)	`ATCTAT/CCAAAA`	1	V/I	mis¹		4		EU EA WA	420
	rs7317471^1,2	C,F,H	20518085(+)	`GGCTGC/TTTTAA`	1	K/K	syn¹ ese³		12		EU EA WA NA	1056
	rs3742220^1,2	H	20447264(-)	`GACCCC/TGTAGA`	1	P/P	syn¹ ese³		5		EA EU WA	1882

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HapMap Linkage Disequilibrium images for LATS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604861

4 Novoseek disease relationships for LATS2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
warts	82.02	9	10871863 (3), 12624101 (2), 10673337 (2), 15131260 (1) (see all 5)
tumors	35.33	27	15746036 (5), 12370754 (3), 12624101 (2), 15131260 (2) (see all 10)
cancer	17.67	1	10871863 (1)
breast cancer	1.76	10	15746036 (4), 17297610 (2)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/25 PubMed articles for LATS2 gene (see all 25 ):

Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. (PubMed id 10673337)^{1, 2, 3, 4} Yabuta N.... Nojima H. (2000)
Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. (PubMed id 10871863)^{1, 3, 4} Hori T.... Uchiyama T. (2000)
The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. (PubMed id 15131260)^{1, 3, 4} Powzaniuk M.... Bai C. (2004)
Lats2, a putative tumor suppressor, inhibits G1/S transition. (PubMed id 12853976)^{1, 3, 4} Li Y.... Tao W. (2003)
LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. (PubMed id 16413547)^{3, 4} Abe Y.... Yamamoto T. (2006)
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PubMed id 15688006)^{3, 4} Chan E.H.Y.... Sillje H.H.W. (2005)
The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. (PubMed id 15147269)^{3, 4} Toji S.... Nojima H. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. (PubMed id 15746036)^{1, 3} Takahashi Y....Noguchi S. (2005)
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. (PubMed id 17049657)^{1, 3} Jiang Z....Lu D. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 26524	HGNC: 6515	AceView: LATS2	Ensembl:ENSG00000150457	euGenes: HUgn26524
ECgene: LATS2	H-InvDB: LATS2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for LATS2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for LATS2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for LATS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LATS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LATS2		Antibodies for LATS2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LATS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for LATS2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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LATS2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for LATS2

Summaries
for LATS2

Genomic Location
for LATS2

Proteins
for LATS2

Protein Domains/
Families
for LATS2

Gene Function
for LATS2

Pathways & Interactions
for LATS2

Drugs & Compounds
for LATS2

Transcripts
for LATS2

Expression
for LATS2

Orthologs
for LATS2

Paralogs
for LATS2

SNPs/Variants
for LATS2

Disorders & Mutations
for LATS2

Medical News
for LATS2

Publications
for LATS2

Search for LATS2

Genome Databases showing LATS2

Other Databases showing LATS2

Specialized Databases showing LATS2

Licensable Technologies
for LATS2

Services
for LATS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LATS2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor LATS2

Summariesfor LATS2

Genomic Locationfor LATS2

Proteinsfor LATS2

Protein Domains/Familiesfor LATS2

Gene Functionfor LATS2

Pathways & Interactionsfor LATS2

Drugs & Compoundsfor LATS2

Transcriptsfor LATS2

Expression for LATS2

Orthologsfor LATS2

Paralogsfor LATS2

SNPs/Variantsfor LATS2

Disorders & Mutationsfor LATS2

Medical Newsfor LATS2

Publicationsfor LATS2

Search for LATS2

Genome Databases showing LATS2

Other Databases showing LATS2

Specialized Databases showing LATS2

Licensable Technologiesfor LATS2

Servicesfor LATS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LATS2

Summaries
for LATS2

Genomic Location
for LATS2

Proteins
for LATS2

Protein Domains/
Families
for LATS2

Gene Function
for LATS2

Pathways & Interactions
for LATS2

Drugs & Compounds
for LATS2

Transcripts
for LATS2

Expression
for LATS2

Orthologs
for LATS2

Paralogs
for LATS2

SNPs/Variants
for LATS2

Disorders & Mutations
for LATS2

Medical News
for LATS2

Publications
for LATS2

Licensable Technologies
for LATS2

Services
for LATS2