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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LATS2 Gene

protein-coding   GIFtS: 65
GCID: GC13M021547

Large Tumor Suppressor Kinase 2

(Previous names: LATS (large tumor suppressor, Drosophila) homolog 2, LATS,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Large Tumor Suppressor Kinase 21 2     EC 2.7.11.13 8
LATS (Large Tumor Suppressor, Drosophila) Homolog 21 2     LATS, Large Tumor Suppressor, Homolog 2 (Drosophila)1
Kinase Phosphorylated During Mitosis Protein2 3     LATS, Large Tumor Suppressor, Homolog 22
Large Tumor Suppressor Homolog 22 3     Serine/Threonine Kinase KPM2
Serine/Threonine-Protein Kinase Kpm2 3     Serine/Threonine-Protein Kinase LATS22
Warts-Like Kinase2 3     EC 2.7.118
KPM2 3     

External Ids:    HGNC: 65151   Entrez Gene: 265242   Ensembl: ENSG000001504577   OMIM: 6048615   UniProtKB: Q9NRM73   

Export aliases for LATS2 gene to outside databases

Previous GC identifers: GC13M019528 GC13M015527 GC13M020478 GC13M019346 GC13M020446 GC13M002350


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LATS2 Gene:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein
localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal
proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset
of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with
p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive
gene expression. (provided by RefSeq, Jul 2008)

GeneCards Summary for LATS2 Gene: 
LATS2 (large tumor suppressor kinase 2) is a protein-coding gene. Diseases associated with LATS2 include intracranial abscess, and cholinergic urticaria, and among its related super-pathways are Signaling by GPCR and DNA Damage. GO annotations related to this gene include protein serine/threonine kinase activity and metal ion binding. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7
Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size
control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is
composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into
the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as
a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and
genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention
and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration
activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ

Gene Wiki entry for LATS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LATS2 gene promoter:
         Tal-1   p53   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Cdc5   GATA-1   FOXL1   E47   Arnt   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LATS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LATS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LATS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q11-q12   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11-q12

LATS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LATS2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M021547:  view genomic region     (about GC identifiers)

Start:
21,547,171 bp from pter      End:
21,635,722 bp from pter
Size:
88,552 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase LATS2  
Size: 1088 amino acids; 120136 Da
Cofactor: Magnesium
Subunit: Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and this
complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome.
Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP
and AJUBA. Interacts with SNAI1
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm,
cytoskeleton, spindle pole. Nucleus. Note=Co-localizes with AURKA at the centrosomes during interphase, early
prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.
Translocates to the nucleus upon mitotic stress by nocodazole treatment
Sequence caution: Sequence=BAA92381.1; Type=Frameshift; Positions=512, 526;
Secondary accessions: B1AM47 Q9P2X1

Explore the universe of human proteins at neXtProt for LATS2: NX_Q9NRM7

Explore proteomics data for LATS2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and
    activated by STK3/MST2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRM7

  • 4/8 DME Specific Peptides for LATS2 (Q9NRM7) (see all 8)
     YIAPEVL  GHIKLTD  KLTDFGL  DIKPDNI 

    LATS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LATS2 Protein Expression
    REFSEQ proteins: NP_055387.2  
    ENSEMBL proteins: 
     ENSP00000372035   ENSP00000441817  
    Reactome Protein details: Q9NRM7
    Human Recombinant Protein Products for LATS2: 
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    Novus Biologicals LATS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LATS2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA12853976
    GO:0005634nucleus NAS10673337
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--

    LATS2 for ontologies           About GeneDecksing



    LATS2 Antibody Products: 
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    Abcam antibodies for LATS2
    Cloud-Clone Corp. Antibodies for LATS2 
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    LSBio Antibodies in human, mouse, rat for LATS2 

    Assay Products for LATS2: 
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    Cloud-Clone Corp. ELISAs for LATS2 
    Cloud-Clone Corp. CLIAs for LATS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: LATS, large tumor suppressor, homolog 2 (Drosophila) 
    Other AGC kinases
    NDR family

    5/9 InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q9NRM7

    ProtoNet protein and cluster: Q9NRM7

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    LATS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LATS2_HUMAN, Q9NRM7
    Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size
    control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is
    composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
    phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
    and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into
    the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as
    a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and
    genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
    Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention
    and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration
    activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for LATS2:
    LATS Drosophila large tumor suppressor,homolog 2,same as Drosophila loss of the warts

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16413547
    GO:0005524ATP binding IDA10871863
         
    LATS2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LATS2:
     Increased ID2::GFP protein exp  Increased apoptosis 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lats2):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size  homeostasis/metabolism  mortality/aging  muscle  nervous system 

    LATS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lats2tm1Noj for LATS2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LATS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LATS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LATS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LATS2 

    miRNA
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    miRTarBase miRNAs that target LATS2:
    hsa-mir-372 (MIRT002446), hsa-mir-373 (MIRT001754), hsa-mir-31 (MIRT000491)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LATS2
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate LATS2 (see all 57):
    hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-25 hsa-miR-3074-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidLATS2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector: LATS2 (NM_014572)
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                         Customized lentivirus expression plasmids for stable overexpression of LATS2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LATS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.55
    2DNA Damage
    Cell Cycle / Checkpoint Control0.32
    3Signaling by Hippo
    Signaling by Hippo
    4Hippo signaling pathway
    Hippo signaling pathway
    5Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for LATS2
        Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for LATS2
        Coregulation of Androgen receptor activity

    2        Reactome Pathways for LATS2
        Signaling by Hippo
    Signal Transduction


    1         Kegg Pathway  (Kegg details for LATS2):
        Hippo signaling pathway


    LATS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LATS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for LATS2 (Q9NRM71, 2, 3 ENSP000003720354) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AJUBAQ96IF12, 3, ENSP000002627134MINT-1772128 MINT-1778030 MINT-1772055 MINT-1790017 MINT-1771993 MINT-1772097 I2D: score=2 STRING: ENSP00000262713
    MOB1AQ9H8S91, 3, ENSP000003793644EBI-3506895,EBI-748229 I2D: score=1 STRING: ENSP00000379364
    MOB1BQ7L9L41, 3, ENSP000003101894EBI-3506895,EBI-2558745 I2D: score=1 STRING: ENSP00000310189
    SNAI1O958632, ENSP000002440504MINT-8313496 MINT-8313510 STRING: ENSP00000244050
    STK3Q131883, ENSP000003905004I2D: score=2 STRING: ENSP00000390500
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA12853976
    GO:0006468protein phosphorylation IDA10871863
    GO:0007067mitosis IEA--
    GO:0007243intracellular protein kinase cascade IDA10871863
    GO:0009755hormone-mediated signaling pathway IDA15131260

    LATS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LATS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LATS2

    3 HMDB Compounds for LATS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for LATS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 25.9 2 12624101 (1), 10871863 (1)
    serine 10.8 2 12624101 (1), 10871863 (1)

    Search CenterWatch for drugs/clinical trials and news about LATS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LATS2 gene: 
    NM_014572.2  

    Unigene Cluster for LATS2:

    LATS, large tumor suppressor, homolog 2 (Drosophila)
    Hs.78960  [show with all ESTs]
    Unigene Representative Sequence: NM_014572
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382592(uc009zzs.3 uc001unr.4) ENST00000472754 ENST00000542899

    miRNA
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    hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-25 hsa-miR-3074-3p hsa-miR-30d
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    Additional mRNA sequence: 

    AB028019.1 AF207547.1 AK027853.1 AK123520.1 AK314235.1 BC036437.1 BC071572.1 

    12 DOTS entries:

    DT.100039184  DT.40291556  DT.436795  DT.445806  DT.91797242  DT.120783972  DT.40249141  DT.100041790 
    DT.40289254  DT.95169192  DT.99971266  DT.95109747 

    24/144 AceView cDNA sequences (see all 144):

    BM978230 AI636200 AA620865 AI566207 BQ898648 BQ574712 BQ926752 AI224095 
    AI580897 AW073767 AW297573 AF207547 BM673297 AI273460 BI964175 AA954532 
    BE999991 NM_014572 BQ445980 AA873139 AI003807 BM052863 AA431967 AI087266 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LATS2 expression in normal human tissues (normalized intensities)      LATS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTAGGTTC
    LATS2 Expression
    About this image


    LATS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Blood (Hematopoietic System)
             nk cells   
     
     Testis (Reproductive System)

    See LATS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LATS2

    SOURCE GeneReport for Unigene cluster: Hs.78960

    UniProtKB/Swiss-Prot: LATS2_HUMAN, Q9NRM7
    Tissue specificity: Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues
    examined

        SABiosciences Expression via Pathway-Focused PCR Array including LATS2: 
              Hedgehog Signaling Pathway in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LATS2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lats21 , 5 large tumor suppressor 21, 5 82.48(n)1
    86.69(a)1
      14 (30.28 cM)5
    505231  NM_015771.21  NP_056586.21 
     576420775 
    chicken
    (Gallus gallus)
    Aves LATS21 LATS, large tumor suppressor, homolog 2 (Drosophila) 72.5(n)
    78.98(a)
      418949  XM_417143.3  XP_417143.3 
    lizard
    (Anolis carolinensis)
    Reptilia LATS26
    Uncharacterized protein
    74(a)
    1 ↔ 1
    3(187653641-187724849)
    zebrafish
    (Danio rerio)
    Actinopterygii lats21 LATS, large tumor suppressor, homolog 2 (Drosophila) 64.04(n)
    68.53(a)
      567674  NM_001123307.1  NP_001116779.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wts3 G1/S transition of mitotic cell cycle
    protein more
    73(a)   100A5   --


    ENSEMBL Gene Tree for LATS2 (if available)
    TreeFam Gene Tree for LATS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LATS2 gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK38L2  STK382  MASTL2  CIT2  
    ROCK12  CDC42BPA2  ROCK22  
    2 SIMAP similar genes for LATS2 using alignment to 1 protein entry:     LATS2_HUMAN:
    LATS1    PRKACG

    LATS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2190 SNPs in LATS2 are shown (see all 2190)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406694
    A lung adenocarcinoma sample4--see VAR_0406692 G E mis40--------
    rs95523141,2
    C,F--21546891(+) ATCACC/TCACCA 1 -- ds50017Minor allele frequency- T:0.29NA WA CSA EA 370
    rs1386906421,2
    C--21546963(+) TTTTAC/TGCAAG 1 -- ds50010--------
    rs1417857761,2
    --21546964(+) TTTACA/GCAAGT 1 -- ds50010--------
    rs1877275321,2
    --21547061(+) CCCTGC/TCTGTG 1 -- ds50010--------
    rs118427181,2
    C,F,H--21547096(+) ACAGGG/AGAAGC 1 -- ds50017Minor allele frequency- A:0.29NA WA CSA EA 368
    rs5842991,2
    C,F,O,A--21547127(+) TGAGAG/AAGGCA 1 -- ds50018Minor allele frequency- A:0.22NA WA EA 368
    rs1146018651,2
    F--21547171(+) ACTACG/AGGATT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs5352331,2
    C,F,O,A,H--21547317(-) GTGCCA/GTGTTG 1 -- ut3126Minor allele frequency- G:0.22MN NS EA NA WA 2632
    rs1927394531,2
    --21547355(+) GTCACA/GACGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LATS2 (21547171 - 21635722 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LATS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747072CNV Deletion23290073
    esv1336723CNV Insertion17803354
    nsv64790CNV Loss16902084
    nsv9059CNV Gain18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604861    OMIM disorders: --

    18 diseases for LATS2:    About MalaCards
    intracranial abscess    cholinergic urticaria    urticaria    cerebrovascular accident
    small cell carcinoma    soft tissue sarcoma    germ cell tumors    esophagitis
    esophageal cancer    esophageal squamous cell carcinoma    astrocytoma    sarcoma
    squamous cell carcinoma    gastric cancer    breast cancer    prostate cancer
    prostatitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for LATS2:
    Intracranial abscess

    LATS2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for LATS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    warts 79.6 9 10871863 (3), 12624101 (2), 10673337 (2), 15131260 (1) (see all 5)
    tumors 38.3 35 15746036 (5), 19855428 (3), 12370754 (3), 12624101 (2) (see all 13)
    cancer 16.8 2 10871863 (1), 19799973 (1)
    breast cancer 9.46 11 15746036 (4), 17297610 (2), 19799973 (1)

    Genetic Association Database (GAD): LATS2
    Human Genome Epidemiology (HuGE) Navigator: LATS2 (2 documents)

    Export disorders for LATS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LATS2 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with LATS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. (PubMed id 10673337)1, 2, 3, 9 Yabuta N.... Nojima H. (2000)
    2. Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. (PubMed id 10871863)1, 2, 9 Hori T.... Uchiyama T. (2000)
    3. The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. (PubMed id 15131260)1, 2, 9 Powzaniuk M.... Bai C. (2004)
    4. Lats2, a putative tumor suppressor, inhibits G1/S transition. (PubMed id 12853976)1, 2, 9 Li Y.... Tao W. (2003)
    5. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. (PubMed id 21952048)1, 2 Zhang K....Longmore G.D. (2012)
    6. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    7. Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)1, 2 Chow A....Yang X. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. (PubMed id 18158288)1, 2 Hao Y....Yang X. (2008)
    10. LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. (PubMed id 16413547)1, 2 Abe Y.... Yamamoto T. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26524 HGNC: 6515 AceView: LATS2 Ensembl:ENSG00000150457 euGenes: HUgn26524
    ECgene: LATS2 Kegg: 26524 H-InvDB: LATS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LATS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LATS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LATS2 gene:
    Search GeneIP for patents involving LATS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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