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LATS1 Gene

protein-coding   GIFtS: 64
GCID: GC06M150023

Large Tumor Suppressor Kinase 1

(Previous names: LATS (large tumor suppressor, Drosophila) homolog 1, LATS,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Large Tumor Suppressor Kinase 11 2     EC 2.7.11.13 8
LATS (Large Tumor Suppressor, Drosophila) Homolog 11 2     LATS, Large Tumor Suppressor, Homolog 1 (Drosophila)1
Large Tumor Suppressor Homolog 12 3     LATS, Large Tumor Suppressor, Homolog 12
WARTS2 3     Serine/Threonine-Protein Kinase LATS12
h-warts2 3     wts2
WARTS Protein Kinase2 3     EC 2.7.118

External Ids:    HGNC: 65141   Entrez Gene: 91132   Ensembl: ENSG000001310237   OMIM: 6034735   UniProtKB: O958353   

Export aliases for LATS1 gene to outside databases

Previous GC identifers: GC06M149558 GC06M149892 GC06M9Q0072 GC06M147548


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LATS1 Gene:
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle
dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative
regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex formation via intramolecular binding.
Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic
treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene.
(provided by RefSeq, Jul 2012)

GeneCards Summary for LATS1 Gene:
LATS1 (large tumor suppressor kinase 1) is a protein-coding gene. Diseases associated with LATS1 include childhood kidney neoplasm, and soft tissue sarcoma. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835
Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size
control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is
composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into
the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as
a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic
progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1
kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin
polymerization through negative modulation of LIMK1. May also play a role in endocrine function

Gene Wiki entry for LATS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LATS1 gene promoter:
         NF-1/L   NF-1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLATS1 promoter sequence
   Search Chromatin IP Primers for LATS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LATS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

LATS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LATS1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M150023:  view genomic region     (about GC identifiers)

Start:
149,979,289 bp from pter      End:
150,039,392 bp from pter
Size:
60,104 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase LATS1  
Size: 1130 amino acids; 126870 Da
Cofactor: Magnesium
Subunit: Complexes with CDK1 in early mitosis. LATS1-associated CDK1 has no mitotic cyclin partner and no apparent
kinase activity. Binds phosphorylated ZYX, locating this protein to the mitotic spindle and suggesting a role for
actin regulatory proteins during mitosis. Binds to and colocalizes with LIMK1 at the actomyosin contractile ring
during cytokinesis. Interacts (via PPxY motif 2) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B.
Interacts with LIMD1, WTIP and AJUBA
Secondary accessions: Q6PKD0
Alternative splicing: 2 isoforms:  O95835-1   O95835-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LATS1: NX_O95835

Explore proteomics data for LATS1 at MOPED

Post-translational modifications: 

  • Autophosphorylated and phosphorylated during M-phase of the cell cycle. Phosphorylated by STK3/MST2 at Ser-909 and
    Thr-1079, which results in its activation. Phosphorylation at Ser-464 by NUAK1 and NUAK2 leads to decreased
    protein level and is required to regulate cellular senescence and cellular ploidy1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LATS1 (O95835) (see all 9)
     YIAPEVL  GHIKLTD  KLTDFGL  DIKPDNI 


    See LATS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257448.1  NP_004681.1  

    ENSEMBL proteins: 
     ENSP00000437550   ENSP00000253339   ENSP00000403815   ENSP00000444678   ENSP00000441265  
     ENSP00000444535  
    Reactome Protein details: O95835

    LATS1 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
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    Novus Biologicals LATS1 Protein
    Novus Biologicals LATS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LATS1

    LATS1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals LATS1 Antibodies
    Abcam antibodies for LATS1 (O95835, Q9NRM7)
    Cloud-Clone Corp. Antibodies for LATS1
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    LSBio Antibodies in human, mouse, rat for LATS1

    LATS1 Assay Products:

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    Cloud-Clone Corp. ELISAs for LATS1
    Cloud-Clone Corp. CLIAs for LATS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: LATS, large tumor suppressor, homolog 1 (Drosophila)
    Other AGC kinases
    NDR family

    Selected InterPro protein domains (see all 9):
     IPR000449 UBA/Ts_N
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR028741 LATS1
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry O95835

    ProtoNet protein and cluster: O95835

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    LATS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LATS1_HUMAN, O95835
    Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size
    control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is
    composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
    phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
    and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into
    the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as
    a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic
    progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1
    kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin
    polymerization through negative modulation of LIMK1. May also play a role in endocrine function
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA10518011
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10831611
         
    LATS1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LATS1:
     Decreased focal adhesion (FA)   Decreased sensitivity to pacli  Decreased substrate adherent c 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lats1):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  nervous system  no phenotypic analysis  reproductive system 
     tumorigenesis 

    LATS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LATS1: Lats1tm1Shku Lats1tm1Noj Lats1tm1Tx

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LATS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LATS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LATS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LATS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LATS1:
    hsa-mir-103a-3p (MIRT027020), hsa-mir-335-5p (MIRT016931), hsa-mir-21-5p (MIRT030710), hsa-mir-16-5p (MIRT031514)

    Block miRNA regulation of human, mouse, rat LATS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LATS1 (see all 22):
    hsa-miR-3607-3p hsa-miR-624* hsa-miR-944 hsa-miR-548a-3p hsa-miR-511 hsa-miR-548g hsa-miR-204 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidLATS1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LATS1
    Predesigned siRNA for gene silencing in human, mouse, rat LATS1

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LATS1 (NM_004690)
    Sino Biological Human cDNA Clone for LATS1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LATS1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LATS1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LATS1_HUMAN, O95835: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the
    centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic
    spindle, and midbody, during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    extracellular2
    nucleus2
    plasma membrane2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA10518011
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--

    LATS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LATS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.58
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    4Signaling by Hippo
    Signaling by Hippo
    5Hippo signaling pathway
    Hippo signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for LATS1
        Wnt / Hedgehog / Notch
    Cell Cycle / Checkpoint Control


    1 Reactome Pathway for LATS1
        Signaling by Hippo


    1 Kegg Pathway  (Kegg details for LATS1):
        Hippo signaling pathway


    LATS1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including LATS1: 
              Hedgehog Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LATS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LATS1 (O958351, 2, 3 ENSP000002533394) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUAK1O602851, 2, 3, ENSP000002614024EBI-444209,EBI-1046789 MINT-7717790 MINT-7717777 I2D: score=1 STRING: ENSP00000261402
    LIMK1P536671, 3, ENSP000003367404EBI-444209,EBI-444403 I2D: score=3 STRING: ENSP00000336740
    ZYXQ159421, 3, ENSP000003244224EBI-444209,EBI-444225 I2D: score=3 STRING: ENSP00000324422
    MOB1AQ9H8S91, 3, ENSP000003793644EBI-444209,EBI-748229 I2D: score=1 STRING: ENSP00000379364
    MOB1BQ7L9L41, 3, ENSP000003101894EBI-444209,EBI-2558745 I2D: score=1 STRING: ENSP00000310189
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA15122335
    GO:0000819sister chromatid segregation IDA15122335
    GO:0006468protein phosphorylation IDA10518011
    GO:0007067mitosis IEA--
    GO:0009755hormone-mediated signaling pathway ISS--

    LATS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LATS1

    3 HMDB Compounds for LATS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for LATS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 51 6 17964162 (1), 12372621 (1), 19656388 (1), 17347649 (1)
    serine 38 4 17964162 (1), 12372621 (1), 19656388 (1)



    LATS1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LATS1 gene (2 alternative transcripts): 
    NM_001270519.1  NM_004690.3  

    Unigene Cluster for LATS1:

    LATS, large tumor suppressor, homolog 1 (Drosophila)
    Hs.549084  [show with all ESTs]
    Unigene Representative Sequence: NM_004690
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543571(uc010kif.1 uc003qmu.1 uc010kig.1) ENST00000253339
    ENST00000441107 ENST00000542747(uc003qmv.2) ENST00000392273(uc003qmw.3)
    ENST00000458696 ENST00000542720
    miRNA
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    Block miRNA regulation of human, mouse, rat LATS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LATS1 (see all 22):
    hsa-miR-3607-3p hsa-miR-624* hsa-miR-944 hsa-miR-548a-3p hsa-miR-511 hsa-miR-548g hsa-miR-204 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidLATS1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LATS1
    Clone
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    GenScript: all cDNA clones in your preferred vector: LATS1 (NM_004690)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LATS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LATS1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat LATS1
      QuantiFast Probe-based Assays in human, mouse, rat LATS1

    Additional mRNA sequence: 

    AF104413.1 AF164041.1 AK310422.1 BC002767.1 BC015665.2 EF565125.1 NR_073033.1 

    9 DOTS entries:

    DT.75165770  DT.311585  DT.100709914  DT.92466505  DT.95154705  DT.91741307  DT.95254370  DT.95265838 
    DT.91664466 

    Selected AceView cDNA sequences (see all 119):

    T77888 CA395444 BX956676 BM471367 BM971435 N78349 AF164041 BM806247 
    CA487180 BU183627 CA407555 BF116033 BX646629 BM695486 CR590502 AI613109 
    CD676827 NM_004690 BE093054 BP376503 BQ435947 BI492014 BX485620 BU929005 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LATS1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
    SP1:                          -                 -                             -                     
    SP2:                          -                                                                     
    SP3:                          -                 -                                                   
    SP4:                          -     -     -     -                                                   
    SP5:                                                                                                


    ECgene alternative splicing isoforms for LATS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LATS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LATS1 Expression
    About this image

    LATS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LATS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.549084

    UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835
    Tissue specificity: Expressed in all adult tissues examined except for lung and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including LATS1: 
              Hedgehog Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LATS1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lats11 , 5 large tumor suppressor1, 5 88.04(n)1
    93.18(a)1
      10 (2.29 cM)5
    167981  NM_010690.11  NP_034820.11 
     76812095 
    chicken
    (Gallus gallus)
    Aves LATS11 LATS, large tumor suppressor, homolog 1 (Drosophila) 80.04(n)
    84.94(a)
      421627  XM_004935607.1  XP_004935664.1 
    lizard
    (Anolis carolinensis)
    Reptilia LATS16
    large tumor suppressor kinase 1
    83(a)
    1 ↔ 1
    GL343259.1(271601-296867)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL882955.22   -- 79.07(n)    AL882955.2 
    zebrafish
    (Danio rerio)
    Actinopterygii lats11 LATS, large tumor suppressor, homolog 1 (Drosophila) 63.23(n)
    68.1(a)
      553164  NM_001020510.1  NP_001018346.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wts3 G1/S transition of mitotic cell cycle
    protein more
    73(a)   100A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea T20F10.13 Protein kinase C terminal domain 50(a)   I(10300194-10305901)   --


    ENSEMBL Gene Tree for LATS1 (if available)
    TreeFam Gene Tree for LATS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LATS1 gene
    CDC42BPG2  DMPK2  CDC42BPB2  STK38L2  STK382  MASTL2  CIT2  ROCK12  
    CDC42BPA2  LATS22  ROCK22  
    7 SIMAP similar genes for LATS1 using alignment to 3 protein entries:     LATS1_HUMAN (see all proteins):
    STK38L    LATS2    PRKACG    PRKX    PRKY    SGK2
    SGK1

    LATS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LATS1 (see all 1253)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406664
    A lung adenocarcinoma sample4--see VAR_0406662 M I mis40--------
    VAR_0406674
    A lung large cell carcinoma sample4--see VAR_0406672 R P mis40--------
    rs1154451631,2
    F--149979045(+) AATCTA/GATGGA 2 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1457776361,2
    --149979238(+) TTTGAA/GTCAGA 2 -- ds50010--------
    rs1898614381,2
    --149979243(+) ATCAGA/GAAACA 2 -- ds50010--------
    rs1815712071,2
    --149979281(+) TTTCCA/TCACAT 2 -- ds50010--------
    rs11251,2
    C,F,A,H--149979416(+) TATGCG/AAAACA 2 -- ut31 nc-transcript-variant24Minor allele frequency- A:0.34MN EA NA NS CSA WA 2586
    rs1477688171,2
    --149979490(+) GTTGCC/TACTGA 2 -- ut31 nc-transcript-variant0--------
    rs1492306611,2
    --149979573(+) GGATAC/TATTAA 2 -- ut31 nc-transcript-variant0--------
    rs1853476221,2
    --149979660(+) CACTTA/TAAATA 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for LATS1 (149979289 - 150039392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LATS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732861CNV Deletion23290073
    esv2671976CNV Deletion23128226
    nsv886762CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603473    OMIM disorders: --

    15 diseases for LATS1:    
    About MalaCards
    childhood kidney neoplasm    soft tissue sarcoma    tetraploidy    mesoblastic nephroma
    clear cell sarcoma    nephroblastoma    sarcoma    beckwith-wiedemann syndrome
    conjunctivitis    astrocytoma    esophagitis    breast cancer
    adenocarcinoma    squamous cell carcinoma    malaria

    4 diseases from the University of Copenhagen DISEASES database for LATS1:
    Nephroblastoma     Mesoblastic nephroma     Clear cell sarcoma     Childhood kidney neoplasm

    LATS1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for LATS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    warts 87.3 21 12372621 (5), 17964162 (1), 17258190 (1), 12941273 (1) (see all 10)
    tumors 38.3 38 15746036 (5), 11850843 (4), 19656388 (4), 12372621 (2) (see all 15)
    breast cancer 19.1 11 15746036 (4), 11850843 (1), 19799973 (1), 17297610 (1)

    Genetic Association Database (GAD): LATS1
    Human Genome Epidemiology (HuGE) Navigator: LATS1 (2 documents)

    Export disorders for LATS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LATS1 gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with LATS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. (PubMed id 15122335)1, 2, 3 Iida S.... Saya H. (Oncogene 2004)
    2. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. (PubMed id 9988268)1, 2, 3 Tao W.... Xu T. (Nat. Genet. 1999)
    3. LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. (PubMed id 15220930)1, 2, 9 Yang X.... Xu T. (Nat. Cell Biol. 2004)
    4. Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)1, 2, 9 Chow A.... Yang X. (Int. J. Cancer 2010)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    6. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    7. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. (PubMed id 19927127)1, 2 Humbert N....Bernard D. (EMBO J. 2010)
    8. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. (PubMed id 18158288)1, 2 Hao Y.... Yang X. (J. Biol. Chem. 2008)
    9. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PubMed id 15688006)1, 2 Chan E.H.Y.... Sillje H.H.W. (Oncogene 2005)
    10. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9113 HGNC: 6514 AceView: LATS1 Ensembl:ENSG00000131023 euGenes: HUgn9113
    ECgene: LATS1 Kegg: 9113 H-InvDB: LATS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LATS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LATS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LATS1 gene:
    Search GeneIP for patents involving LATS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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