LATS1 Gene
protein-coding GIFtS: 60
GCID: GC06M150023
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|
LATS, large tumor suppressor, homolog 1 (Drosophila)(Previous names: LATS (large tumor suppressor, Drosophila) homolog 1 )
| |
Aliases
for LATS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| LATS, Large Tumor Suppressor, Homolog 1 (Drosophila)1 2 | | WARTS Protein Kinase2 3 | | WARTS1 2 3 | | EC 2.7.11.13 8 | | LATS (Large Tumor Suppressor, Drosophila) Homolog 11 2 | | Serine/Threonine-Protein Kinase LATS12 | | Large Tumor Suppressor Homolog 12 3 | | Wts1 | | H-Warts1 | | EC 2.7.118 |
Export aliases for LATS1 gene to outside databasesPrevious GC identifers: GC06M149558 GC06M149892 GC06M9Q0072 GC06M147548 |
Summaries
for LATS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LATS1:
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus andcomplexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycledependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the proteinbinds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator ofCDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potentialnegative regulation through interference with complex formation via intramolecular binding. Biochemical and geneticdata suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development ofsoft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Twoprotein-coding transcripts and one non-protein coding transcript have been found for this gene. (provided by RefSeq,Jul 2012)
UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control andtumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of akinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulatecellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor whichplays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidycheckpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control ofp53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May alsoplay a role in endocrine function
Gene Wiki entry for LATS1
|
Genomic Views
for LATS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LATS1 gene promoter:
NF-1/L NF-1 p53
Other transcription factors
Search SABiosciences Chromatin IP Primers for LATS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LATS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q25.1LATS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M150023: view genomic region
(about GC identifiers)
Start:
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149,979,289 bp from pter |
End:
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150,039,392 bp from pter |
Size:
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60,104 bases |
Orientation:
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minus strand |
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Proteins
for LATS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase LATS1 Size: 1130 amino acids; 126870 Da
Cofactor: Magnesium
Subunit: Complexes with CDK1 in early mitosis. LATS1-associated CDK1 has no mitotic cyclin partner and no apparentkinase activity. Binds phosphorylated ZYX, locating this protein to the mitotic spindle and suggesting a role foractin regulatory proteins during mitosis. Binds to and colocalizes with LIMK1 at the actomyosin contractile ringduring cytokinesis. Interacts (via PPxY motif 2) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interactswith LIMD1, WTIP and AJUBA
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Note=Localizes to the centrosomes throughout interphase butmigrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis
Secondary accessions: Q6PKD0Alternative splicing: 2 isoforms: O95835-1 O95835-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for LATS1: NX_O95835
Post-translational modifications:
Autophosphorylated and phosphorylated during M-phase of the cell cycle. Phosphorylated by STK3/MST2 at Ser-909 andThr-1079, which results in its activation. Phosphorylation at Ser-464 by NUAK1 and NUAK2 leads to decreased proteinlevel and is required to regulate cellular senescence and cellular ploidy1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95835
4/9 DME Specific Peptides for LATS1 (O95835) (see all 9)
LATS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001257448.1 NP_004681.1
ENSEMBL proteins: ENSP00000437550 ENSP00000253339 ENSP00000403815 ENSP00000444678 ENSP00000441265 ENSP00000444535 Reactome Protein details: O95835
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
LATS1 for ontologies About GeneDecksing
LATS1 Antibody Products:
Assay Products for LATS1: |
Protein
Domains /
Families
for LATS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LATS1 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry O95835ProtoNet protein and cluster: O95835 1 Blocks protein family: IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase familySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 UBA domain |
Function
for LATS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control andtumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of akinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulatecellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor whichplays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidycheckpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control ofp53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May alsoplay a role in endocrine functionCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LATS1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LATS1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LATS1 (NM_004690) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LATS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LATS1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
LATS1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for LATS1:
Animal Models:
Mouse knock-outs for LATS1: Lats1tm1Noj Lats1tm1Tx
10 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Lats1):
LATS1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for LATS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell Cycle / Checkpoint Control | | | 2 | Signaling by Hippo | | | 3 | Wnt / Hedgehog / Notch | | | 4 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for LATS1
2 
Reactome Pathways for LATS1
LATS1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LATS1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/43 Interacting proteins for LATS1 (O958351, 2, 3 ENSP000002533394) via UniProtKB, MINT, STRING, and/or I2D (see all 43)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| NUAK1 | O602852, 3, ENSP000002614024 | MINT-7717790 MINT-7717777 I2D:
score=1 STRING: ENSP00000261402 | | LIMK1 | P536671, 3, ENSP000003367404 | EBI-444209,EBI-444403 I2D:
score=3 STRING: ENSP00000336740 | | ZYX | Q159421, 3, ENSP000003244224 | EBI-444209,EBI-444225 I2D:
score=3 STRING: ENSP00000324422 | | MOB1A | Q9H8S91, 3, ENSP000003793644 | EBI-444209,EBI-748229 I2D:
score=1 STRING: ENSP00000379364 | | MOB1B | Q7L9L41, 3, ENSP000003101894 | EBI-444209,EBI-2558745 I2D:
score=1 STRING: ENSP00000310189 |
About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
LATS1 for ontologies About GeneDecksing
|
Drugs & Compounds
for LATS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
LATS1 for compounds About GeneDecksing
 Browse Tocris compounds for LATS1
3 HMDB Compounds for LATS1 About this table
2 Novoseek chemical compound relationships for LATS1 gene About this table
Search CenterWatch for drugs/clinical trials and news about LATS1
|
Transcripts
for LATS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LATS1 gene (2 alternative transcripts): NM_001270519.1 NM_004690.3 Unigene Cluster for LATS1: LATS, large tumor suppressor, homolog 1 (Drosophila) Hs.549084 [show with all ESTs]Unigene Representative Sequence: NM_0046907 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000543571(uc010kif.1 uc003qmu.1 uc010kig.1) ENST00000253339
ENST00000441107 ENST00000542747(uc003qmv.2) ENST00000392273(uc003qmw.3)
ENST00000458696 ENST00000542720
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LATS1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LATS1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LATS1 (NM_004690) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LATS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LATS1 |
Additional cDNA sequence: AF104413.1 AF164041.1 AK310422.1 BC002767.1 BC015665.2 EF565125.1 NR_073033.1 9 DOTS entries: DT.75165770 DT.311585 DT.100709914 DT.92466505 DT.95154705 DT.91741307 DT.91664466 DT.95254370 DT.95265838 24/119 AceView cDNA sequences (see all 119): BX646629 NM_004690 BM971435 BF116033 CA407555 BM695486 N78349 CR590502 AF164041 CD676827 AI613109 T77888 CA395444 CA487180 BM471367 BM806247 BU183627 BX956676 D60654 BM973695 AI783534 AA347257 BX957081 BQ435947
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for LATS1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LATS1
|
Expression
for LATS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LATS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LATS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LATS1
SOURCE GeneReport for Unigene cluster: Hs.549084
UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835Tissue specificity: Expressed in all adult tissues examined except for lung and kidney
SABiosciences Expression via Pathway-Focused PCR Array including LATS1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LATS1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LATS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LATS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LATS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS1 |
Orthologs
for LATS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LATS1 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LATS11 |
LATS, large tumor suppressor, homolog 1 (Drosophila) |
80.51(n)
85.74(a) |
|
421627 XM_419666.3 XP_419666.2 |
lizard
(Anolis carolinensis) |
Reptilia |
LATS16 |
-- |
83(a) |
1 ↔ 1 |
GL343259.1(276488-296751) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
AL882955.22 |
-- |
79.07(n) |
|
AL882955.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
lats11 |
LATS, large tumor suppressor, homolog 1 (Drosophila) |
62.92(n)
68.16(a) |
|
553164 NM_001020510.1 NP_001018346.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
wts1 , 3 |
G1/S transition of mitotic cell cycle
protein more3
warts1 |
73(a)3
50.43(n)1
52.24(a)1 |
|
100A53
436511 NM_170524.11 NP_733403.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
T20F10.13 |
Protein kinase C terminal domain |
50(a) |
|
I(10300194-10305901) -- |
ENSEMBL Gene Tree for LATS1 (if available)
TreeFam Gene Tree for LATS1 (if available) |
Paralogs
for LATS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LATS1 gene
- CDC42BPG2 DMPK2 STK38L2 CDC42BPB2 STK382 CIT2 ROCK12 LATS22
- CDC42BPA2 ROCK22
7 SIMAP similar genes for LATS1 using alignment to 3 protein entries: LATS1_HUMAN (see all proteins):STK38L LATS2 PRKACG PRKX PRKY SGK2
SGK1
LATS1 for paralogs About GeneDecksing
|
Genomic Variants
for LATS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LATS1 (149979289 - 150039392 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for LATS1
3 CNVs: 36467 0603 36466
1 Indel: 40929 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LATS1 |
|
Disorders
/ Diseases
for LATS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LATS1 for disorders About GeneDecksing
OMIM gene information: 603473
OMIM disorders: --
13  diseases for LATS1: About MalaCardssoft tissue sarcoma sarcoma beckwith-wiedemann syndrome clear cell sarcoma
tetraploidy squamous cell carcinoma nephroblastoma breast cancer
conjunctivitis astrocytoma esophagitis adenocarcinoma
carcinoma
4 diseases from the University of Copenhagen DISEASES database for LATS1:Nephroblastoma Mesoblastic nephroma Clear cell sarcoma Childhood kidney neoplasm 3 Novoseek disease relationships for LATS1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: LATS1 (2 documents)
Export disorders for LATS1 gene to outside databases
|
Publications
for LATS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LATS1 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with LATS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. (PubMed id 15122335)1, 2, 3 Iida S.... Saya H. (2004)
- Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. (PubMed id 9988268)1, 2, 3 Tao W.... Xu T. (1999)
- LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. (PubMed id 15220930)1, 2, 9 Yang X.... Xu T. (2004)
- Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)1, 2, 9 Chow A....Yang X. (2010)
- Regulation of ploidy and senescence by the AMPK-relat ed kinase NUAK1. (PubMed id 19927127)1, 2 Humbert N....Bernard D. (2010)
- Tumor suppressor LATS1 is a negative regulator of oncogene YAP. (PubMed id 18158288)1, 2 Hao Y....Yang X. (2008)
- The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PubMed id 15688006)1, 2 Chan E.H.Y.... Sillje H.H.W. (2005)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. (PubMed id 10831611)1, 2 Hirota T.... Saya H. (2000)
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External Searches for LATS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing LATS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing LATS1 gene
(According to HUGE)
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Specialized Databases showing LATS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for LATS1 gene:
Search GeneIP for patents involving LATS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for LATS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LATS1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LATS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LATS1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LATS1 | | OriGene 3'-UTR Clone for LATS1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LATS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LATS1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LATS1 | | OriGene Custom Protein Services for LATS1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LATS1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LATS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LATS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LATS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LATS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LATS1 |
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| | Antibodies & Assays for LATS1 |
| | | | Search Tocris compounds for LATS1 |
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 | | | LATS1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LATS1 |
|  |  |  | | | | ThermoFisher Antibodies for LATS1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LATS1 |
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