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LATS1 Gene

protein-coding GIFtS: 53

GC06M150023

LATS, large tumor suppressor, homolog 1 (Drosophila)
(Previous names: LATS (large tumor suppressor, Drosophila) homolog 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.1 ^³
WARTS ^¹, ², ³
h-warts ^³
wts ^²

Descriptions
LATS (large tumor suppressor, Drosophila) homolog 1 ^¹, ²
LATS homolog 1 ^²
LATS, large tumor suppressor, homolog 1 (Drosophila) ^²
Large tumor suppressor homolog 1 ^³
WARTS protein kinase ^³

External Ids
HGNC: 6514¹
Entrez Gene: 9113²
UniProtKB: O95835³
Ensembl: ENSG00000131023⁷

Search outside databases for aliases for LATS1 gene

Previous GC identifers: GC06M149558 GC06M149892 GC06M9Q0072

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LATS1:

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the

mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The

protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation

remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex

showing reduced H1 histone kinase activity, indicating a role as a negative regulator of

CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region,

suggesting potential negative regulation through interference with complex formation via

intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is

supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal

cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq]

UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835

Function: Tumor suppressor which plays a critical role in maintenance of ploidy through its actions

in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M

transition by down-regulating CDC2 kinase activity. Involved in the control of p53 expression.

Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May

also play a role in endocrine function

Gene Wiki entry for LATS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LATS1 gene

Entrez Gene cytogenetic band: 6q24-q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q25.1

LATS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M150023: (about GC identifiers)

Start:	150,023,744 bp from pter
End:	150,081,085 bp from pter
Size:	57,342 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase LATS1

Size: 1130 amino acids; 126870 Da

Cofactor: Magnesium

Subunit: Complexes with CDC2 in early mitosis. LATS1-associated CDC2 has no mitotic cyclin partner

and no apparent kinase activity. Binds phosphorylated ZYX, locating this protein to the mitotic

spindle and suggesting a role for actin regulatory proteins during mitosis. Binds to and

colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis

Subcellular location: Centrosome. Note=Localizes to the centrosomes throughout interphase but

migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody,

during mitosis

Secondary accessions: Q6PKD0

Alternative splicing: 2 isoforms: O95835-1 O95835-2

Post-translational modifications:

Autophosphorylated and phosphorylated during M-phase of the cell cycle. Phosphorylated by STK3 at

Ser-909 and Thr-1079, which results in its activation. Phosphorylated upon DNA damage, probably by

ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004681.1

ENSEMBL proteins:

ENSP00000253339 ENSP00000376099

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LATS1)
	Human Recombinant Proteins from Abnova (LATS1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	10518011
GO:0005813	centrosome	IEA	--

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Antibodies for LATS1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LATS1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for LATS1
	Antibodies from Abcam (LATS1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LATS1)
	Novus Biologicals Antibodies for LATS1

Assays for LATS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95835

ProtoNet protein and cluster: O95835

1 Blocks protein family: IPB000961 Protein kinase C-terminal domain

UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 UBA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LATS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LATS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004690

Applied Biosystems Silencer® siRNAs for LATS1

Sigma-Aldrich siRNA and siRNA Panels for LATS1

Sigma-Aldrich shRNA Panels and shRNA for LATS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LATS1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004690
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004690
untagged cDNA clones in CMV expression vector (see all 2): NM_004690

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004690

UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835

Function: Tumor suppressor which plays a critical role in maintenance of ploidy through its actions

in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M

transition by down-regulating CDC2 kinase activity. Involved in the control of p53 expression.

Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May

also play a role in endocrine function

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1

10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lats1):

	endocrine/exocrine gland	growth/size	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	nervous system	no phenotypic analysis	reproductive system	tumorigenesis

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IDA	10518011
GO:0004674	protein serine/threonine kinase activity	IDA	10518011
GO:0005515	protein binding	IPI	9988268 10831611 15220930
GO:0005524	ATP binding	IDA	10518011

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for LATS1

5/18 Interacting proteins for LATS1 (O95835¹ ENSP00000253339³) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC2	P06493¹, ENSP00000362917³	EBI-444209, EBI-444308 STRING (score=.873)
ZYX	Q15942¹, ENSP00000346417³	EBI-444209, EBI-444225 STRING (score=.82)
LIMK1	P53667¹, ENSP00000336740³	EBI-444209, EBI-444403 STRING (score=.765)
MOBKL1B	ENSP00000264089³	STRING (score=.981)
MOBKL1A	ENSP00000310189³	STRING (score=.978)

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	IDA	15122335
GO:0000819	sister chromatid segregation	IDA	15122335
GO:0006468	protein amino acid phosphorylation	IDA	10518011
GO:0007067	mitosis	IEA	--
GO:0009755	hormone-mediated signaling	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LATS1
1 Novoseek chemical compound relationship for LATS1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	50.24	5	17964162 (1), 12372621 (1), 17347649 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LATS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LATS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004690

Sigma-Aldrich siRNA and siRNA Panels for LATS1

Sigma-Aldrich shRNA Panels and shRNA for LATS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004690

REFSEQ mRNAs for LATS1 gene:

NM_004690.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004690

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004690
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004690
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004690

Additional cDNA sequence:

AF104413.1 AF164041.1 AK310422.1 BC002767.1 BC015665.2 EF565125.1

6 DOTS entries:

DT.75165770 DT.100709914 DT.92466505 DT.91741307 DT.95154705 DT.95265838

24/119 AceView cDNA sequences (see all 119 ):

BM471367 CA407555 BM695486 AF164041 T77888 BX646629 BM806247 CR590502

BM971435 BF116033 N78349 AI613109 CA395444 NM_004690 BX956676 CD676827

CA487180 BU183627 AW502306 AA205048 BE093054 BU682349 CD654501 CF619282

highest scoring ESTs for LATS1:

AF104413 BC002767 BE395243 BX956676 AA205048 AA206195 AA910802 AF164041 AI114863 AV708169

Unigene Cluster for LATS1:

LATS, large tumor suppressor, homolog 1 (Drosophila)

Hs.716697 [show with all ESTs]

Unigene Representative Sequence: NM_004690

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for LATS1

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9
SP1:									-						-										-
SP2:									-
SP3:									-						-
SP4:									-		-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for LATS1

2 Ensembl transcripts including schematic representations:

ENST00000253339 ENST00000392273

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LATS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LATS1

¹ / ² / ³

4 probe-sets matching LATS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
219813_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004690	0.60	1.00	0.82	1
1570231_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219813_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1570425_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.716697
UniProtKB/Swiss-Prot: LATS1_HUMAN, O95835
Tissue specificity: Expressed in all adult tissues examined except for lung and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LATS1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LATS1¹	--	LATS, large tumor suppressor, homolog 1 (Drosophila)	93.55(n) 95.25(a)	476241 NM_001024635.1 NP_001019806.1
chimpanzee (Pan troglodytes)	LATS1¹	--	LATS, large tumor suppressor, homolog 1 (Drosophila)	99.53(n) 99.65(a)	748397 XM_001173355.1 XP_001173355.1
cow (Bos taurus)	LATS1¹	--	LATS, large tumor suppressor, homolog 1 (Drosophila)	92.94(n) 95.55(a)	535935 XM_616050.3 XP_616050.3
rat (Rattus norvegicus)	RGD1564085¹	--	similar to LATS homolog 1	90.17(n) 97.61(a)	308265 XM_218062.4 XP_218062.4
mouse (Mus musculus)	Lats1^{1, 5}	10⁵	large tumor suppressor^{1, 5}	88.04(n)¹ 93.18(a)¹	16798¹ XM_618738.3¹ XP_618738.2¹ AF104414⁵ AK029530⁵ (see all 16)

About this table Species with no ortholog for LATS1

ENSEMBL Gene Tree for LATS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LATS1 gene

ROCK1² LATS2² ROCK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/278 NCBI SNPs in LATS1 are shown (see all 278 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 65)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4870509^1,2	A,C,F,H	150065041(+)	`ATGATG/CCTTCA`	1	--	ut5¹		10		EU EA WA NA	808
--	rs2297932^1,2	A,C,F,O	150081054(-)	`CGGGCC/GACGCA`	1	--	ut5¹ ese³		3		NA	140
	rs9800736^1,2	A,C,F,H	150024110(+)	`AAAACG/AAGGTT`	1	--	ut3¹		4		EU EA WA	418
--	rs12174349^1,2	A,C,F,H	150080841(+)	`GTCGTA/GAGGAC`	1	--	ut5¹ ese³		4		EU EA WA	404
	rs2297928^1,2	A,C,F,O	150081413(-)	`CCTGGG/CTCAAG`	1	--	ng3¹		6		EA NA	1054
	rs2297930^1,2	A,F,H	150081189(-)	`GATCAG/ATGGGG`	1	--	ng3¹		5		EA EU WA	1888
	rs3806983^1,2	C,F,H	150082426(+)	`CTCTAG/CTCTTT`	1	--	ng3¹		8		EA NA EU WA	1850
	rs2297929^1,2	H	150081350(-)	`TGTTCG/AGGGAA`	1	--	ng3¹ trp³		4		EU EA WA	418
	rs2297931^1,2	H	150081123(-)	`GCGGGC/AGAGTC`	1	--	ng3¹		4		EU EA WA	420
--	rs9767113^1,2	A	150080986(+)	`AGGACC/TGGGGG`	1	--	ut5¹ ese³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for LATS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603473

3 Novoseek disease relationships for LATS1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
warts	86.48	19	12372621 (5), 17964162 (1), 17258190 (1), 16096061 (1) (see all 8)
tumors	33.18	28	15746036 (5), 11850843 (4), 12372621 (2), 17049657 (1) (see all 11)
breast cancer	8.11	10	15746036 (4), 11850843 (1), 17297610 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/43 PubMed articles for LATS1 gene (see all 43 ):

Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. (PubMed id 15122335)^{2, 3, 4} Iida S....Saya H. (2004)
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. (PubMed id 9988268)^{2, 3, 4} Tao W.... Xu T. (1999)
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. (PubMed id 15220930)^{1, 3, 4} Yang X.... Xu T. (2004)
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PubMed id 15688006)^{3, 4} Chan E.H.Y.... Sillje H.H.W. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. (PubMed id 10831611)^{3, 4} Hirota T.... Saya H. (2000)
A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. (PubMed id 10518011)^{3, 4} Nishiyama Y.... Saya H. (1999)
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. (PubMed id 17049657)^{1, 3} Jiang Z....Lu D. (2006)
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. (PubMed id 15746036)^{1, 3} Takahashi Y....Noguchi S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9113	HGNC: 6514	AceView: LATS1	Ensembl:ENSG00000131023	euGenes: HUgn9113
ECgene: LATS1	H-InvDB: LATS1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LATS1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for LATS1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LATS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LATS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LATS1		Antibodies for LATS1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LATS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LATS1)
	Antibodies (LATS1)
	Chimera RNAi (LATS1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for LATS1

	Recombinant Proteins (LATS1)
	Antibodies (LATS1)

Search OriGene for LATS1

Search Tocris compounds for LATS1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LATS1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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LATS1 Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for LATS1

Summaries
for LATS1

Genomic Location
for LATS1

Proteins
for LATS1

Protein Domains/
Families
for LATS1

Gene Function
for LATS1

Pathways & Interactions
for LATS1

Drugs & Compounds
for LATS1

Transcripts
for LATS1

Expression
for LATS1

Orthologs
for LATS1

Paralogs
for LATS1

SNPs/Variants
for LATS1

Disorders & Mutations
for LATS1

Medical News
for LATS1

Publications
for LATS1

Search for LATS1

Genome Databases showing LATS1

Other Databases showing LATS1

Specialized Databases showing LATS1

Licensable Technologies
for LATS1

Services
for LATS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LATS1 Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor LATS1

Summariesfor LATS1

Genomic Locationfor LATS1

Proteinsfor LATS1

Protein Domains/Familiesfor LATS1

Gene Functionfor LATS1

Pathways & Interactionsfor LATS1

Drugs & Compoundsfor LATS1

Transcriptsfor LATS1

Expression for LATS1

Orthologsfor LATS1

Paralogsfor LATS1

SNPs/Variantsfor LATS1

Disorders & Mutationsfor LATS1

Medical Newsfor LATS1

Publicationsfor LATS1

Search for LATS1

Genome Databases showing LATS1

Other Databases showing LATS1

Specialized Databases showing LATS1

Licensable Technologiesfor LATS1

Servicesfor LATS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LATS1

Summaries
for LATS1

Genomic Location
for LATS1

Proteins
for LATS1

Protein Domains/
Families
for LATS1

Gene Function
for LATS1

Pathways & Interactions
for LATS1

Drugs & Compounds
for LATS1

Transcripts
for LATS1

Expression
for LATS1

Orthologs
for LATS1

Paralogs
for LATS1

SNPs/Variants
for LATS1

Disorders & Mutations
for LATS1

Medical News
for LATS1

Publications
for LATS1

Licensable Technologies
for LATS1

Services
for LATS1